Motif 609 (n=189)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | S33 | ochoa | Protein FAM234B | None |
| A6H8Y1 | BDP1 | S420 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NKT7 | RGPD3 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BU86 | STX16-NPEPL1 | S201 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| O00193 | SMAP | S82 | ochoa | Small acidic protein | None |
| O00273 | DFFA | S110 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00410 | IPO5 | S827 | ochoa | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}. |
| O00505 | KPNA3 | S56 | ochoa | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. |
| O14662 | STX16 | S201 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14715 | RGPD8 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14787 | TNPO2 | S355 | ochoa | Transportin-2 (Karyopherin beta-2b) | Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}. |
| O14976 | GAK | S817 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15164 | TRIM24 | S1019 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O43615 | TIMM44 | S185 | ochoa | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| O43670 | ZNF207 | S104 | psp | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}. |
| O43719 | HTATSF1 | S676 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43791 | SPOP | S119 | psp | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}. |
| O43815 | STRN | S239 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60271 | SPAG9 | S347 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60763 | USO1 | S942 | ochoa|psp | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O60832 | DKC1 | S422 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O60841 | EIF5B | S214 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O95171 | SCEL | S344 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95197 | RTN3 | S246 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| P04921 | GYPC | S104 | ochoa | Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) | This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. |
| P05060 | CHGB | S380 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05067 | APP | S198 | psp | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. |
| P06213 | INSR | S1314 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P06241 | FYN | S186 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07237 | P4HB | S281 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07910 | HNRNPC | S253 | ochoa|psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P07947 | YES1 | S195 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | S166 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P09769 | FGR | S181 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0DJD0 | RGPD1 | S1002 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1010 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | S81 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S254 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P13639 | EEF2 | S587 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P13693 | TPT1 | S64 | psp | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
| P15498 | VAV1 | S683 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P16383 | GCFC2 | S217 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P17252 | PRKCA | S226 | ochoa|psp | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P18583 | SON | S1782 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P21730 | C5AR1 | S327 | ochoa|psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P22059 | OSBP | S193 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22059 | OSBP | S198 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P23634 | ATP2B4 | S237 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P24821 | TNC | S86 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P26358 | DNMT1 | S192 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27797 | CALR | S193 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P28290 | ITPRID2 | S410 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P32780 | GTF2H1 | S357 | ochoa | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}. |
| P35269 | GTF2F1 | S345 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35612 | ADD2 | S535 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P35659 | DEK | S243 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P36776 | LONP1 | S176 | ochoa | Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:14739292, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:8248235}. |
| P41236 | PPP1R2 | S121 | ochoa|psp | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P46013 | MKI67 | S2708 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S1881 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49736 | MCM2 | S229 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49768 | PSEN1 | S319 | ochoa|psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P49792 | RANBP2 | S1993 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50461 | CSRP3 | S156 | ochoa | Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein) | Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}. |
| P51114 | FXR1 | S485 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P52732 | KIF11 | Y125 | psp | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P62714 | PPP2CB | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| P78345 | RPP38 | S226 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| P82094 | TMF1 | S217 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q00987 | MDM2 | S253 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01538 | MYT1 | S94 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q03001 | DST | S2527 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q0JRZ9 | FCHO2 | S304 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q0ZGT2 | NEXN | S160 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12802 | AKAP13 | S1945 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12872 | SFSWAP | S282 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12874 | SF3A3 | S295 | ochoa | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q12888 | TP53BP1 | S29 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S530 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13217 | DNAJC3 | S274 | ochoa | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}. |
| Q13442 | PDAP1 | S63 | ochoa | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}. |
| Q13547 | HDAC1 | S393 | ochoa | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q13557 | CAMK2D | S333 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q14161 | GIT2 | S384 | psp | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q15018 | ABRAXAS2 | S79 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
| Q15022 | SUZ12 | S384 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15022 | SUZ12 | S546 | ochoa|psp | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15051 | IQCB1 | S572 | ochoa | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}. |
| Q15149 | PLEC | S1448 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15910 | EZH2 | S375 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q16665 | HIF1A | S551 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q2TBE0 | CWF19L2 | S484 | ochoa | CWF19-like protein 2 | None |
| Q32MZ4 | LRRFIP1 | S638 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q5JSH3 | WDR44 | S50 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5JSH3 | WDR44 | S66 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5QJE6 | DNTTIP2 | S134 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | S178 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S485 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S488 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5UIP0 | RIF1 | S1579 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q6KC79 | NIPBL | T2667 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6N043 | ZNF280D | S802 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6NXS1 | PPP1R2B | S121 | ochoa|psp | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6P0Q8 | MAST2 | S806 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PL18 | ATAD2 | S746 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UX04 | CWC27 | S250 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6ZNL6 | FGD5 | S59 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZRV2 | FAM83H | S788 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q7L590 | MCM10 | S54 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z3J3 | RGPD4 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5K2 | WAPL | S461 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q86T90 | KIAA1328 | S68 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86VR2 | RETREG3 | S325 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q8IUI4 | SNX29P2 | S191 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IVF5 | TIAM2 | S1565 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8IYB3 | SRRM1 | S874 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYD8 | FANCM | S1417 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IYW5 | RNF168 | S393 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
| Q8N0S6 | CENPL | S53 | ochoa | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}. |
| Q8NEV8 | EXPH5 | S706 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEZ4 | KMT2C | S1228 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFQ8 | TOR1AIP2 | S63 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8TAQ2 | SMARCC2 | S387 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TB72 | PUM2 | S136 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TEQ0 | SNX29 | S344 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEW0 | PARD3 | S1046 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WVS4 | DYNC2I1 | S79 | ochoa | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}. |
| Q8WXH0 | SYNE2 | S2784 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WYK0 | ACOT12 | S161 | ochoa | Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743). {ECO:0000269|PubMed:16951743}. |
| Q96DR7 | ARHGEF26 | S296 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96JG6 | VPS50 | S546 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
| Q96JQ2 | CLMN | S841 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96K76 | USP47 | S910 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96QE3 | ATAD5 | S308 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96SN8 | CDK5RAP2 | S1663 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99549 | MPHOSPH8 | S264 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99666 | RGPD5 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99733 | NAP1L4 | S299 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q9BXK5 | BCL2L13 | S420 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXW9 | FANCD2 | S1407 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9H1E3 | NUCKS1 | S58 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H1Y3 | OPN3 | S380 | psp | Opsin-3 (Encephalopsin) (Panopsin) | G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31097585, PubMed:31380578). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q9WUK7, ECO:0000269|PubMed:28842328, ECO:0000269|PubMed:30168605, ECO:0000269|PubMed:31097585, ECO:0000269|PubMed:31380578, ECO:0000269|PubMed:31730232}. |
| Q9H4G0 | EPB41L1 | S60 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H582 | ZNF644 | S820 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6T3 | RPAP3 | S119 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H814 | PHAX | S340 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H999 | PANK3 | S283 | ochoa | Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) | Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:17631502, ECO:0000269|PubMed:20797618, ECO:0000269|PubMed:27555321, ECO:0000269|PubMed:30927326}. |
| Q9HB90 | RRAGC | S95 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9HCH5 | SYTL2 | S571 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NR48 | ASH1L | S1191 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRX5 | SERINC1 | S351 | ochoa | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}. |
| Q9NS91 | RAD18 | S322 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NUL3 | STAU2 | S194 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NWH9 | SLTM | S294 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9P2I0 | CPSF2 | S423 | ochoa | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
| Q9P2R3 | ANKFY1 | S861 | ochoa | Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}. |
| Q9P2R6 | RERE | S53 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UHC6 | CNTNAP2 | S1303 | ochoa | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}. |
| Q9UHC6 | CNTNAP2 | S1306 | ochoa | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}. |
| Q9UK59 | DBR1 | S499 | ochoa | Lariat debranching enzyme (EC 3.1.4.-) | Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}. |
| Q9ULH0 | KIDINS220 | S1526 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULK5 | VANGL2 | S58 | ochoa | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
| Q9UP95 | SLC12A4 | S973 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UQM7 | CAMK2A | S333 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y490 | TLN1 | S417 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4W2 | LAS1L | S238 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5A7 | NUB1 | S489 | ochoa | NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}. |
| A0MZ66 | SHTN1 | S444 | Sugiyama | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| P11279 | LAMP1 | S141 | Sugiyama | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}. |
| Q6PKG0 | LARP1 | S830 | Sugiyama | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q8WVM8 | SCFD1 | S340 | Sugiyama | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1182 | Sugiyama | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q9Y2B0 | CNPY2 | S139 | Sugiyama | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| A6NMY6 | ANXA2P2 | S243 | Sugiyama | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| P07355 | ANXA2 | S243 | Sugiyama | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| O43526 | KCNQ2 | S558 | SIGNOR|iPTMNet|EPSD | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| P08575 | PTPRC | S1004 | SIGNOR | Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:2845400, ECO:0000269|PubMed:35767951}.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}. |
| Q8WVJ2 | NUDCD2 | S106 | Sugiyama | NudC domain-containing protein 2 | May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269|PubMed:20133715}. |
| Q00987 | MDM2 | S373 | PSP | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q13428 | TCOF1 | S341 | Sugiyama | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| P31327 | CPS1 | S540 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Q13043 | STK4 | S65 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13188 | STK3 | S62 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q12802 | AKAP13 | S1294 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q8N5S9 | CAMKK1 | S111 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| P60842 | EIF4A1 | S300 | Sugiyama | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| Q9P0L2 | MARK1 | S447 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UK32 | RPS6KA6 | S223 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.884034e-07 | 6.005 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 6.647482e-06 | 5.177 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.734836e-06 | 5.059 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.457931e-05 | 4.609 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 3.152050e-05 | 4.501 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.186514e-04 | 3.926 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.100000e-04 | 3.959 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.534544e-04 | 3.814 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.954321e-04 | 3.709 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.214050e-04 | 3.655 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.214050e-04 | 3.655 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.267286e-04 | 3.486 |
| R-HSA-111933 | Calmodulin induced events | 3.050952e-04 | 3.516 |
| R-HSA-111997 | CaM pathway | 3.050952e-04 | 3.516 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.493286e-04 | 3.457 |
| R-HSA-201556 | Signaling by ALK | 4.139631e-04 | 3.383 |
| R-HSA-111996 | Ca-dependent events | 6.018400e-04 | 3.221 |
| R-HSA-1433557 | Signaling by SCF-KIT | 6.574307e-04 | 3.182 |
| R-HSA-1489509 | DAG and IP3 signaling | 7.800434e-04 | 3.108 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.508776e-04 | 3.124 |
| R-HSA-210990 | PECAM1 interactions | 9.228827e-04 | 3.035 |
| R-HSA-111885 | Opioid Signalling | 9.698076e-04 | 3.013 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.167678e-03 | 2.933 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.306670e-03 | 2.884 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.382781e-03 | 2.859 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.952066e-03 | 2.710 |
| R-HSA-1640170 | Cell Cycle | 1.890575e-03 | 2.723 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.952066e-03 | 2.710 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.312156e-03 | 2.636 |
| R-HSA-5673000 | RAF activation | 2.335912e-03 | 2.632 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.312156e-03 | 2.636 |
| R-HSA-112043 | PLC beta mediated events | 2.461000e-03 | 2.609 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.768775e-03 | 2.558 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 3.002301e-03 | 2.523 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.126584e-03 | 2.505 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.623103e-03 | 2.441 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.516405e-03 | 2.454 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.749515e-03 | 2.426 |
| R-HSA-112040 | G-protein mediated events | 3.504013e-03 | 2.455 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.084556e-03 | 2.389 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.129989e-03 | 2.384 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.711728e-03 | 2.327 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.832046e-03 | 2.316 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.218494e-03 | 2.282 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 5.835499e-03 | 2.234 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 5.835499e-03 | 2.234 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 5.835499e-03 | 2.234 |
| R-HSA-1500931 | Cell-Cell communication | 5.747155e-03 | 2.241 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 6.445646e-03 | 2.191 |
| R-HSA-9669938 | Signaling by KIT in disease | 6.445646e-03 | 2.191 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.184130e-03 | 2.209 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.555209e-03 | 2.183 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.659997e-03 | 2.177 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.973664e-03 | 2.157 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.784117e-03 | 2.169 |
| R-HSA-446728 | Cell junction organization | 7.039941e-03 | 2.152 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.198209e-03 | 2.143 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 8.054416e-03 | 2.094 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.054416e-03 | 2.094 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.175081e-03 | 2.088 |
| R-HSA-9620244 | Long-term potentiation | 8.497891e-03 | 2.071 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.495286e-03 | 2.071 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 8.054416e-03 | 2.094 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.463571e-03 | 2.127 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.674844e-03 | 2.062 |
| R-HSA-73887 | Death Receptor Signaling | 8.674844e-03 | 2.062 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.661626e-03 | 2.015 |
| R-HSA-438064 | Post NMDA receptor activation events | 9.647584e-03 | 2.016 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 9.661626e-03 | 2.015 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.252217e-03 | 2.034 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.005443e-02 | 1.998 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.005551e-02 | 1.998 |
| R-HSA-72172 | mRNA Splicing | 1.082910e-02 | 1.965 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.056161e-02 | 1.976 |
| R-HSA-176974 | Unwinding of DNA | 1.139888e-02 | 1.943 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.139888e-02 | 1.943 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.096699e-02 | 1.960 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.268369e-02 | 1.897 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.226603e-02 | 1.911 |
| R-HSA-69481 | G2/M Checkpoints | 1.241152e-02 | 1.906 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.251516e-02 | 1.903 |
| R-HSA-69206 | G1/S Transition | 1.164620e-02 | 1.934 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.179957e-02 | 1.928 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.312629e-02 | 1.882 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.342090e-02 | 1.872 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.524888e-02 | 1.817 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.524888e-02 | 1.817 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.524888e-02 | 1.817 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.735447e-02 | 1.761 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.957583e-02 | 1.708 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.957583e-02 | 1.708 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.957583e-02 | 1.708 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.957583e-02 | 1.708 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.957583e-02 | 1.708 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.021248e-02 | 1.694 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.785964e-02 | 1.748 |
| R-HSA-4839744 | Signaling by APC mutants | 1.524888e-02 | 1.817 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.735447e-02 | 1.761 |
| R-HSA-202670 | ERKs are inactivated | 1.735447e-02 | 1.761 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.735447e-02 | 1.761 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.735447e-02 | 1.761 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.362483e-02 | 1.866 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.021248e-02 | 1.694 |
| R-HSA-373755 | Semaphorin interactions | 1.547338e-02 | 1.810 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.824262e-02 | 1.739 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.735447e-02 | 1.761 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.771346e-02 | 1.752 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.824262e-02 | 1.739 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.566871e-02 | 1.805 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.735447e-02 | 1.761 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.566871e-02 | 1.805 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.506244e-02 | 1.822 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.506244e-02 | 1.822 |
| R-HSA-162582 | Signal Transduction | 2.079004e-02 | 1.682 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.126568e-02 | 1.672 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.187603e-02 | 1.660 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.190955e-02 | 1.659 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.190955e-02 | 1.659 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.190955e-02 | 1.659 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.236054e-02 | 1.651 |
| R-HSA-109582 | Hemostasis | 2.246316e-02 | 1.649 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.690086e-02 | 1.570 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.690086e-02 | 1.570 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.824563e-02 | 1.549 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.690086e-02 | 1.570 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.690086e-02 | 1.570 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.746022e-02 | 1.561 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.658977e-02 | 1.575 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.590528e-02 | 1.587 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.824563e-02 | 1.549 |
| R-HSA-4839726 | Chromatin organization | 2.854531e-02 | 1.544 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.863264e-02 | 1.543 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.955200e-02 | 1.529 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.955200e-02 | 1.529 |
| R-HSA-421270 | Cell-cell junction organization | 2.963156e-02 | 1.528 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.972634e-02 | 1.527 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.033822e-02 | 1.518 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.076642e-02 | 1.512 |
| R-HSA-9833482 | PKR-mediated signaling | 3.076642e-02 | 1.512 |
| R-HSA-9710421 | Defective pyroptosis | 3.124735e-02 | 1.505 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.278955e-02 | 1.484 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.280853e-02 | 1.484 |
| R-HSA-69236 | G1 Phase | 3.280853e-02 | 1.484 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.280853e-02 | 1.484 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.771786e-02 | 1.423 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.771786e-02 | 1.423 |
| R-HSA-3928664 | Ephrin signaling | 3.809003e-02 | 1.419 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.605083e-02 | 1.443 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.605083e-02 | 1.443 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.605083e-02 | 1.443 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.531425e-02 | 1.452 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.605083e-02 | 1.443 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.809003e-02 | 1.419 |
| R-HSA-2028269 | Signaling by Hippo | 3.514962e-02 | 1.454 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.945181e-02 | 1.404 |
| R-HSA-8953854 | Metabolism of RNA | 3.771307e-02 | 1.424 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 4.112091e-02 | 1.386 |
| R-HSA-68875 | Mitotic Prophase | 3.438002e-02 | 1.464 |
| R-HSA-75153 | Apoptotic execution phase | 3.605083e-02 | 1.443 |
| R-HSA-418990 | Adherens junctions interactions | 4.116098e-02 | 1.386 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.121131e-02 | 1.385 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.549934e-02 | 1.342 |
| R-HSA-198753 | ERK/MAPK targets | 4.744263e-02 | 1.324 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 6.429738e-02 | 1.192 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 5.753370e-02 | 1.240 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 5.753370e-02 | 1.240 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.308042e-02 | 1.200 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.519287e-02 | 1.186 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.191367e-02 | 1.208 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 6.429738e-02 | 1.192 |
| R-HSA-350054 | Notch-HLH transcription pathway | 5.409246e-02 | 1.267 |
| R-HSA-5578775 | Ion homeostasis | 5.460569e-02 | 1.263 |
| R-HSA-9664407 | Parasite infection | 5.986989e-02 | 1.223 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.986989e-02 | 1.223 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.986989e-02 | 1.223 |
| R-HSA-9675108 | Nervous system development | 6.078602e-02 | 1.216 |
| R-HSA-418594 | G alpha (i) signalling events | 6.152374e-02 | 1.211 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.592583e-02 | 1.252 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.200634e-02 | 1.208 |
| R-HSA-168255 | Influenza Infection | 5.026536e-02 | 1.299 |
| R-HSA-2029481 | FCGR activation | 4.970146e-02 | 1.304 |
| R-HSA-3000170 | Syndecan interactions | 5.753370e-02 | 1.240 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.820167e-02 | 1.235 |
| R-HSA-6807070 | PTEN Regulation | 5.858612e-02 | 1.232 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.308042e-02 | 1.200 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.308042e-02 | 1.200 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.308042e-02 | 1.200 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.308042e-02 | 1.200 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 6.104902e-02 | 1.214 |
| R-HSA-8863678 | Neurodegenerative Diseases | 6.104902e-02 | 1.214 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 6.104902e-02 | 1.214 |
| R-HSA-2262752 | Cellular responses to stress | 6.240315e-02 | 1.205 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.887104e-02 | 1.230 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.308042e-02 | 1.200 |
| R-HSA-449147 | Signaling by Interleukins | 5.114644e-02 | 1.291 |
| R-HSA-68877 | Mitotic Prometaphase | 6.535597e-02 | 1.185 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 6.829182e-02 | 1.166 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.856125e-02 | 1.164 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 7.201438e-02 | 1.143 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 7.201438e-02 | 1.143 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 7.201438e-02 | 1.143 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.212468e-02 | 1.142 |
| R-HSA-418346 | Platelet homeostasis | 7.377929e-02 | 1.132 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.504158e-02 | 1.125 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 7.580120e-02 | 1.120 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 7.580120e-02 | 1.120 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 7.580120e-02 | 1.120 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 7.580120e-02 | 1.120 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 7.665428e-02 | 1.115 |
| R-HSA-422475 | Axon guidance | 7.685310e-02 | 1.114 |
| R-HSA-74713 | IRS activation | 8.884875e-02 | 1.051 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 8.884875e-02 | 1.051 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.127589e-01 | 0.948 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.244787e-01 | 0.905 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.360444e-01 | 0.866 |
| R-HSA-444257 | RSK activation | 1.360444e-01 | 0.866 |
| R-HSA-170984 | ARMS-mediated activation | 1.474580e-01 | 0.831 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.474580e-01 | 0.831 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.587216e-01 | 0.799 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.587216e-01 | 0.799 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.808062e-01 | 0.743 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.808062e-01 | 0.743 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.916312e-01 | 0.718 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.916312e-01 | 0.718 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.916312e-01 | 0.718 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.023138e-01 | 0.694 |
| R-HSA-9006335 | Signaling by Erythropoietin | 7.964995e-02 | 1.099 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.128558e-01 | 0.672 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.128558e-01 | 0.672 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.232592e-01 | 0.651 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.232592e-01 | 0.651 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.335258e-01 | 0.632 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.335258e-01 | 0.632 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.254561e-01 | 0.902 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.298837e-01 | 0.886 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.298837e-01 | 0.886 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.388450e-01 | 0.857 |
| R-HSA-167161 | HIV Transcription Initiation | 1.388450e-01 | 0.857 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.388450e-01 | 0.857 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.479364e-01 | 0.830 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.571450e-01 | 0.804 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.191688e-01 | 0.924 |
| R-HSA-72187 | mRNA 3'-end processing | 1.901252e-01 | 0.721 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.901252e-01 | 0.721 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.949133e-01 | 0.710 |
| R-HSA-72649 | Translation initiation complex formation | 1.997166e-01 | 0.700 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.093642e-01 | 0.679 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.148881e-01 | 0.668 |
| R-HSA-167169 | HIV Transcription Elongation | 1.298837e-01 | 0.886 |
| R-HSA-72086 | mRNA Capping | 7.964995e-02 | 1.099 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.298837e-01 | 0.886 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.571450e-01 | 0.804 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.190584e-01 | 0.659 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.254561e-01 | 0.902 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.924705e-02 | 1.049 |
| R-HSA-8849473 | PTK6 Expression | 1.244787e-01 | 0.905 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.232592e-01 | 0.651 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.012360e-01 | 0.696 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.012360e-01 | 0.696 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 8.670427e-02 | 1.062 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 8.884875e-02 | 1.051 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.298837e-01 | 0.886 |
| R-HSA-6798695 | Neutrophil degranulation | 1.070733e-01 | 0.970 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.587216e-01 | 0.799 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 1.008829e-01 | 0.996 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.127589e-01 | 0.948 |
| R-HSA-419771 | Opsins | 1.244787e-01 | 0.905 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.474580e-01 | 0.831 |
| R-HSA-192905 | vRNP Assembly | 1.698370e-01 | 0.770 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.916312e-01 | 0.718 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 7.964995e-02 | 1.099 |
| R-HSA-4791275 | Signaling by WNT in cancer | 9.154524e-02 | 1.038 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.039188e-01 | 0.983 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.298837e-01 | 0.886 |
| R-HSA-5620924 | Intraflagellar transport | 1.711508e-01 | 0.767 |
| R-HSA-9766229 | Degradation of CDH1 | 1.758651e-01 | 0.755 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.078915e-01 | 0.967 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.336674e-01 | 0.631 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.336674e-01 | 0.631 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.617120e-01 | 0.791 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.081400e-01 | 0.966 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.183320e-01 | 0.661 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 9.561942e-02 | 1.019 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.664584e-01 | 0.779 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.360444e-01 | 0.866 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.384586e-01 | 0.859 |
| R-HSA-8963888 | Chylomicron assembly | 1.698370e-01 | 0.770 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.024182e-01 | 0.990 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.045340e-01 | 0.689 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 1.585324e-01 | 0.800 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.708185e-02 | 1.013 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.298837e-01 | 0.886 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.298837e-01 | 0.886 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.996910e-01 | 0.700 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.127589e-01 | 0.948 |
| R-HSA-8964041 | LDL remodeling | 1.244787e-01 | 0.905 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 1.360444e-01 | 0.866 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.360444e-01 | 0.866 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.587216e-01 | 0.799 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.808062e-01 | 0.743 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.254561e-01 | 0.902 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.239201e-01 | 0.650 |
| R-HSA-191859 | snRNP Assembly | 2.239201e-01 | 0.650 |
| R-HSA-169893 | Prolonged ERK activation events | 2.335258e-01 | 0.632 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.949133e-01 | 0.710 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.142060e-01 | 0.669 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.930097e-02 | 1.003 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.142060e-01 | 0.669 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.239201e-01 | 0.650 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.360444e-01 | 0.866 |
| R-HSA-4641265 | Repression of WNT target genes | 1.916312e-01 | 0.718 |
| R-HSA-983189 | Kinesins | 2.287901e-01 | 0.641 |
| R-HSA-8951664 | Neddylation | 2.187997e-01 | 0.660 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.343473e-01 | 0.872 |
| R-HSA-68886 | M Phase | 9.113639e-02 | 1.040 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.388450e-01 | 0.857 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.456234e-02 | 1.024 |
| R-HSA-8866376 | Reelin signalling pathway | 8.884875e-02 | 1.051 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.244787e-01 | 0.905 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.587216e-01 | 0.799 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.901252e-01 | 0.721 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 9.561942e-02 | 1.019 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.134763e-01 | 0.945 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.081400e-01 | 0.966 |
| R-HSA-194138 | Signaling by VEGF | 1.177924e-01 | 0.929 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.571450e-01 | 0.804 |
| R-HSA-397014 | Muscle contraction | 1.977423e-01 | 0.704 |
| R-HSA-8866423 | VLDL assembly | 1.127589e-01 | 0.948 |
| R-HSA-164944 | Nef and signal transduction | 1.127589e-01 | 0.948 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.244787e-01 | 0.905 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.474580e-01 | 0.831 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.474580e-01 | 0.831 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.916312e-01 | 0.718 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.916312e-01 | 0.718 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.916312e-01 | 0.718 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.335258e-01 | 0.632 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.919327e-02 | 1.101 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.127999e-01 | 0.948 |
| R-HSA-74160 | Gene expression (Transcription) | 1.976464e-01 | 0.704 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.686900e-01 | 0.773 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.922603e-02 | 1.050 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.479364e-01 | 0.830 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.023138e-01 | 0.694 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.571450e-01 | 0.804 |
| R-HSA-68882 | Mitotic Anaphase | 2.070133e-01 | 0.684 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.093535e-01 | 0.679 |
| R-HSA-112316 | Neuronal System | 1.191696e-01 | 0.924 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.093642e-01 | 0.679 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.474580e-01 | 0.831 |
| R-HSA-74749 | Signal attenuation | 1.587216e-01 | 0.799 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.128558e-01 | 0.672 |
| R-HSA-437239 | Recycling pathway of L1 | 1.664584e-01 | 0.779 |
| R-HSA-69190 | DNA strand elongation | 9.154524e-02 | 1.038 |
| R-HSA-388396 | GPCR downstream signalling | 1.748476e-01 | 0.757 |
| R-HSA-70171 | Glycolysis | 1.844825e-01 | 0.734 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 9.972449e-02 | 1.001 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.853536e-01 | 0.732 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.916312e-01 | 0.718 |
| R-HSA-8876725 | Protein methylation | 2.232592e-01 | 0.651 |
| R-HSA-416700 | Other semaphorin interactions | 2.232592e-01 | 0.651 |
| R-HSA-597592 | Post-translational protein modification | 1.741022e-01 | 0.759 |
| R-HSA-1226099 | Signaling by FGFR in disease | 9.706008e-02 | 1.013 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.474580e-01 | 0.831 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 1.200179e-01 | 0.921 |
| R-HSA-2559583 | Cellular Senescence | 1.277344e-01 | 0.894 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.006641e-01 | 0.997 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.164505e-01 | 0.934 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.525268e-01 | 0.817 |
| R-HSA-166520 | Signaling by NTRKs | 1.810235e-01 | 0.742 |
| R-HSA-9658195 | Leishmania infection | 2.134030e-01 | 0.671 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.134030e-01 | 0.671 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.360444e-01 | 0.866 |
| R-HSA-180024 | DARPP-32 events | 7.964995e-02 | 1.099 |
| R-HSA-5621480 | Dectin-2 family | 2.142060e-01 | 0.669 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.000463e-01 | 0.699 |
| R-HSA-190236 | Signaling by FGFR | 1.778897e-01 | 0.750 |
| R-HSA-9008059 | Interleukin-37 signaling | 8.355835e-02 | 1.078 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 9.561942e-02 | 1.019 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.746185e-01 | 0.758 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 7.964995e-02 | 1.099 |
| R-HSA-1474244 | Extracellular matrix organization | 9.844289e-02 | 1.007 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 8.884875e-02 | 1.051 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.388450e-01 | 0.857 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.388450e-01 | 0.857 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.039188e-01 | 0.983 |
| R-HSA-913531 | Interferon Signaling | 9.218219e-02 | 1.035 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.024182e-01 | 0.990 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 9.154524e-02 | 1.038 |
| R-HSA-1474290 | Collagen formation | 1.617120e-01 | 0.791 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.698370e-01 | 0.770 |
| R-HSA-168268 | Virus Assembly and Release | 2.335258e-01 | 0.632 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.901252e-01 | 0.721 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.239201e-01 | 0.650 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.368548e-01 | 0.864 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.148881e-01 | 0.668 |
| R-HSA-450294 | MAP kinase activation | 2.336674e-01 | 0.631 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.254561e-01 | 0.902 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.778897e-01 | 0.750 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.778897e-01 | 0.750 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.778897e-01 | 0.750 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.183320e-01 | 0.661 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.217874e-01 | 0.654 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.217874e-01 | 0.654 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.046296e-01 | 0.689 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.322181e-01 | 0.634 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.385508e-01 | 0.622 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.427366e-01 | 0.615 |
| R-HSA-73894 | DNA Repair | 2.434702e-01 | 0.614 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.436572e-01 | 0.613 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.436572e-01 | 0.613 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.436572e-01 | 0.613 |
| R-HSA-196783 | Coenzyme A biosynthesis | 2.436572e-01 | 0.613 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.436572e-01 | 0.613 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.497922e-01 | 0.602 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.497922e-01 | 0.602 |
| R-HSA-373760 | L1CAM interactions | 2.497922e-01 | 0.602 |
| R-HSA-195721 | Signaling by WNT | 2.498421e-01 | 0.602 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.529180e-01 | 0.597 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.529180e-01 | 0.597 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.532285e-01 | 0.596 |
| R-HSA-70326 | Glucose metabolism | 2.533317e-01 | 0.596 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.536553e-01 | 0.596 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.586942e-01 | 0.587 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.604323e-01 | 0.584 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.604323e-01 | 0.584 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.630268e-01 | 0.580 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.635219e-01 | 0.579 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.635219e-01 | 0.579 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.635219e-01 | 0.579 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.635219e-01 | 0.579 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.635219e-01 | 0.579 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.635219e-01 | 0.579 |
| R-HSA-3371556 | Cellular response to heat stress | 2.675588e-01 | 0.573 |
| R-HSA-167172 | Transcription of the HIV genome | 2.679272e-01 | 0.572 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.679272e-01 | 0.572 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.680376e-01 | 0.572 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.711308e-01 | 0.567 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.711308e-01 | 0.567 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.728272e-01 | 0.564 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.732587e-01 | 0.563 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.732587e-01 | 0.563 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.732587e-01 | 0.563 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.732587e-01 | 0.563 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.732587e-01 | 0.563 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.777261e-01 | 0.556 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.777261e-01 | 0.556 |
| R-HSA-448424 | Interleukin-17 signaling | 2.777261e-01 | 0.556 |
| R-HSA-372790 | Signaling by GPCR | 2.800748e-01 | 0.553 |
| R-HSA-3000178 | ECM proteoglycans | 2.826230e-01 | 0.549 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.828673e-01 | 0.548 |
| R-HSA-373753 | Nephrin family interactions | 2.828673e-01 | 0.548 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.828673e-01 | 0.548 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.828673e-01 | 0.548 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.875170e-01 | 0.541 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.875170e-01 | 0.541 |
| R-HSA-69275 | G2/M Transition | 2.908855e-01 | 0.536 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.923495e-01 | 0.534 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.923495e-01 | 0.534 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.924075e-01 | 0.534 |
| R-HSA-4086398 | Ca2+ pathway | 2.924075e-01 | 0.534 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.924075e-01 | 0.534 |
| R-HSA-114608 | Platelet degranulation | 2.926617e-01 | 0.534 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.962632e-01 | 0.528 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.968014e-01 | 0.528 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.972937e-01 | 0.527 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.972937e-01 | 0.527 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.017068e-01 | 0.520 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.017068e-01 | 0.520 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.017068e-01 | 0.520 |
| R-HSA-977347 | Serine metabolism | 3.017068e-01 | 0.520 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.017068e-01 | 0.520 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.017068e-01 | 0.520 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.021748e-01 | 0.520 |
| R-HSA-5617833 | Cilium Assembly | 3.027324e-01 | 0.519 |
| R-HSA-5576891 | Cardiac conduction | 3.106933e-01 | 0.508 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.109411e-01 | 0.507 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.109411e-01 | 0.507 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.109411e-01 | 0.507 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.109411e-01 | 0.507 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.109411e-01 | 0.507 |
| R-HSA-4086400 | PCP/CE pathway | 3.167806e-01 | 0.499 |
| R-HSA-216083 | Integrin cell surface interactions | 3.167806e-01 | 0.499 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.200537e-01 | 0.495 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.200537e-01 | 0.495 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.200537e-01 | 0.495 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.264799e-01 | 0.486 |
| R-HSA-429947 | Deadenylation of mRNA | 3.290464e-01 | 0.483 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.290464e-01 | 0.483 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.290464e-01 | 0.483 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.290464e-01 | 0.483 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.290464e-01 | 0.483 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.313162e-01 | 0.480 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.323733e-01 | 0.478 |
| R-HSA-163685 | Integration of energy metabolism | 3.323733e-01 | 0.478 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.325593e-01 | 0.478 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.379207e-01 | 0.471 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.379207e-01 | 0.471 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.379207e-01 | 0.471 |
| R-HSA-420029 | Tight junction interactions | 3.379207e-01 | 0.471 |
| R-HSA-1280218 | Adaptive Immune System | 3.456355e-01 | 0.461 |
| R-HSA-525793 | Myogenesis | 3.466782e-01 | 0.460 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.466782e-01 | 0.460 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.466782e-01 | 0.460 |
| R-HSA-70635 | Urea cycle | 3.466782e-01 | 0.460 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.466782e-01 | 0.460 |
| R-HSA-212436 | Generic Transcription Pathway | 3.468103e-01 | 0.460 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.505591e-01 | 0.455 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.553204e-01 | 0.449 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.553204e-01 | 0.449 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.553204e-01 | 0.449 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.553204e-01 | 0.449 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.553204e-01 | 0.449 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.553204e-01 | 0.449 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.553204e-01 | 0.449 |
| R-HSA-264876 | Insulin processing | 3.553204e-01 | 0.449 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.576368e-01 | 0.447 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.601113e-01 | 0.444 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.638488e-01 | 0.439 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.638488e-01 | 0.439 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.638488e-01 | 0.439 |
| R-HSA-77387 | Insulin receptor recycling | 3.638488e-01 | 0.439 |
| R-HSA-622312 | Inflammasomes | 3.638488e-01 | 0.439 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.638488e-01 | 0.439 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.722649e-01 | 0.429 |
| R-HSA-5334118 | DNA methylation | 3.722649e-01 | 0.429 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.722649e-01 | 0.429 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.790565e-01 | 0.421 |
| R-HSA-69242 | S Phase | 3.791923e-01 | 0.421 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.791923e-01 | 0.421 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.805701e-01 | 0.420 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.805701e-01 | 0.420 |
| R-HSA-2424491 | DAP12 signaling | 3.805701e-01 | 0.420 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.805701e-01 | 0.420 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.805701e-01 | 0.420 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.805701e-01 | 0.420 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.863462e-01 | 0.413 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.887660e-01 | 0.410 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.887660e-01 | 0.410 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.934809e-01 | 0.405 |
| R-HSA-1538133 | G0 and Early G1 | 3.968539e-01 | 0.401 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.968539e-01 | 0.401 |
| R-HSA-69306 | DNA Replication | 3.970405e-01 | 0.401 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.970405e-01 | 0.401 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.977650e-01 | 0.400 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.024021e-01 | 0.395 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.048353e-01 | 0.393 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.048353e-01 | 0.393 |
| R-HSA-354192 | Integrin signaling | 4.048353e-01 | 0.393 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.048353e-01 | 0.393 |
| R-HSA-162587 | HIV Life Cycle | 4.112216e-01 | 0.386 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.127116e-01 | 0.384 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.127116e-01 | 0.384 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.127116e-01 | 0.384 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.127116e-01 | 0.384 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.127116e-01 | 0.384 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.147513e-01 | 0.382 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 4.162107e-01 | 0.381 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.162107e-01 | 0.381 |
| R-HSA-162906 | HIV Infection | 4.162723e-01 | 0.381 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.204841e-01 | 0.376 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.204841e-01 | 0.376 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.204841e-01 | 0.376 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.204841e-01 | 0.376 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.204841e-01 | 0.376 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.204841e-01 | 0.376 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.207782e-01 | 0.376 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.217907e-01 | 0.375 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.281543e-01 | 0.368 |
| R-HSA-187687 | Signalling to ERKs | 4.281543e-01 | 0.368 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.281543e-01 | 0.368 |
| R-HSA-109581 | Apoptosis | 4.288018e-01 | 0.368 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.298584e-01 | 0.367 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.357234e-01 | 0.361 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.357234e-01 | 0.361 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.357234e-01 | 0.361 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.357234e-01 | 0.361 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 4.357234e-01 | 0.361 |
| R-HSA-8853659 | RET signaling | 4.357234e-01 | 0.361 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.357234e-01 | 0.361 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.431927e-01 | 0.353 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.431927e-01 | 0.353 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.431927e-01 | 0.353 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.431927e-01 | 0.353 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.431927e-01 | 0.353 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 4.457317e-01 | 0.351 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.505637e-01 | 0.346 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.505637e-01 | 0.346 |
| R-HSA-157118 | Signaling by NOTCH | 4.544855e-01 | 0.342 |
| R-HSA-69541 | Stabilization of p53 | 4.578375e-01 | 0.339 |
| R-HSA-9648002 | RAS processing | 4.578375e-01 | 0.339 |
| R-HSA-9824446 | Viral Infection Pathways | 4.590854e-01 | 0.338 |
| R-HSA-168256 | Immune System | 4.646813e-01 | 0.333 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.650154e-01 | 0.333 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.650154e-01 | 0.333 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.650154e-01 | 0.333 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.650154e-01 | 0.333 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.650154e-01 | 0.333 |
| R-HSA-69239 | Synthesis of DNA | 4.697555e-01 | 0.328 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.701858e-01 | 0.328 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.720988e-01 | 0.326 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.720988e-01 | 0.326 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.720988e-01 | 0.326 |
| R-HSA-9694548 | Maturation of spike protein | 4.720988e-01 | 0.326 |
| R-HSA-9607240 | FLT3 Signaling | 4.720988e-01 | 0.326 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.740861e-01 | 0.324 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.790888e-01 | 0.320 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 4.790888e-01 | 0.320 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.790888e-01 | 0.320 |
| R-HSA-165159 | MTOR signalling | 4.859867e-01 | 0.313 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.911936e-01 | 0.309 |
| R-HSA-5688426 | Deubiquitination | 4.975170e-01 | 0.303 |
| R-HSA-2172127 | DAP12 interactions | 4.995109e-01 | 0.301 |
| R-HSA-373752 | Netrin-1 signaling | 4.995109e-01 | 0.301 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.995109e-01 | 0.301 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.996158e-01 | 0.301 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.036259e-01 | 0.298 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.061396e-01 | 0.296 |
| R-HSA-774815 | Nucleosome assembly | 5.061396e-01 | 0.296 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.061396e-01 | 0.296 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.061396e-01 | 0.296 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.061396e-01 | 0.296 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.120814e-01 | 0.291 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.126809e-01 | 0.290 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.126809e-01 | 0.290 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.126809e-01 | 0.290 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.126809e-01 | 0.290 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.126809e-01 | 0.290 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.126809e-01 | 0.290 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.126809e-01 | 0.290 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.126809e-01 | 0.290 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.191360e-01 | 0.285 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.199389e-01 | 0.284 |
| R-HSA-983712 | Ion channel transport | 5.231669e-01 | 0.281 |
| R-HSA-5693538 | Homology Directed Repair | 5.243422e-01 | 0.280 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 5.255059e-01 | 0.279 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.295874e-01 | 0.276 |
| R-HSA-168249 | Innate Immune System | 5.296888e-01 | 0.276 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.317919e-01 | 0.274 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.317919e-01 | 0.274 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.317919e-01 | 0.274 |
| R-HSA-73893 | DNA Damage Bypass | 5.317919e-01 | 0.274 |
| R-HSA-199991 | Membrane Trafficking | 5.323780e-01 | 0.274 |
| R-HSA-73886 | Chromosome Maintenance | 5.363953e-01 | 0.271 |
| R-HSA-9748787 | Azathioprine ADME | 5.379950e-01 | 0.269 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 5.379950e-01 | 0.269 |
| R-HSA-1266738 | Developmental Biology | 5.439325e-01 | 0.264 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.441162e-01 | 0.264 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.441162e-01 | 0.264 |
| R-HSA-2514856 | The phototransduction cascade | 5.441162e-01 | 0.264 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.443140e-01 | 0.264 |
| R-HSA-9609690 | HCMV Early Events | 5.454271e-01 | 0.263 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.482381e-01 | 0.261 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.501568e-01 | 0.260 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.501568e-01 | 0.260 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.501568e-01 | 0.260 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.501568e-01 | 0.260 |
| R-HSA-392499 | Metabolism of proteins | 5.515468e-01 | 0.258 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.561176e-01 | 0.255 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.561176e-01 | 0.255 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.561176e-01 | 0.255 |
| R-HSA-1221632 | Meiotic synapsis | 5.561176e-01 | 0.255 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.670763e-01 | 0.246 |
| R-HSA-418597 | G alpha (z) signalling events | 5.678045e-01 | 0.246 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.678045e-01 | 0.246 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.735326e-01 | 0.241 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.735326e-01 | 0.241 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.735326e-01 | 0.241 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.735326e-01 | 0.241 |
| R-HSA-5357801 | Programmed Cell Death | 5.761605e-01 | 0.239 |
| R-HSA-9843745 | Adipogenesis | 5.824862e-01 | 0.235 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.847631e-01 | 0.233 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.847631e-01 | 0.233 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.861721e-01 | 0.232 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.861721e-01 | 0.232 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.902674e-01 | 0.229 |
| R-HSA-180786 | Extension of Telomeres | 5.902674e-01 | 0.229 |
| R-HSA-1643685 | Disease | 5.938245e-01 | 0.226 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.956991e-01 | 0.225 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.042414e-01 | 0.219 |
| R-HSA-1268020 | Mitochondrial protein import | 6.063485e-01 | 0.217 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.063485e-01 | 0.217 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.063485e-01 | 0.217 |
| R-HSA-186797 | Signaling by PDGF | 6.063485e-01 | 0.217 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.113011e-01 | 0.214 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.115680e-01 | 0.214 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.115680e-01 | 0.214 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.115680e-01 | 0.214 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.115680e-01 | 0.214 |
| R-HSA-8848021 | Signaling by PTK6 | 6.115680e-01 | 0.214 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.115680e-01 | 0.214 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.167186e-01 | 0.210 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 6.167186e-01 | 0.210 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.167186e-01 | 0.210 |
| R-HSA-1234174 | Cellular response to hypoxia | 6.218012e-01 | 0.206 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.268168e-01 | 0.203 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.285309e-01 | 0.202 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.319051e-01 | 0.199 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.363376e-01 | 0.196 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.366501e-01 | 0.196 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.366501e-01 | 0.196 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.451642e-01 | 0.190 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.462255e-01 | 0.190 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.509186e-01 | 0.186 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.509186e-01 | 0.186 |
| R-HSA-72312 | rRNA processing | 6.524030e-01 | 0.185 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.555497e-01 | 0.183 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.555497e-01 | 0.183 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.601197e-01 | 0.180 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.601197e-01 | 0.180 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.612062e-01 | 0.180 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.635190e-01 | 0.178 |
| R-HSA-9609507 | Protein localization | 6.643443e-01 | 0.178 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.646293e-01 | 0.177 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.646293e-01 | 0.177 |
| R-HSA-8939211 | ESR-mediated signaling | 6.654014e-01 | 0.177 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.671159e-01 | 0.176 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.674590e-01 | 0.176 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.690794e-01 | 0.175 |
| R-HSA-380287 | Centrosome maturation | 6.690794e-01 | 0.175 |
| R-HSA-8852135 | Protein ubiquitination | 6.690794e-01 | 0.175 |
| R-HSA-1989781 | PPARA activates gene expression | 6.705504e-01 | 0.174 |
| R-HSA-9612973 | Autophagy | 6.736187e-01 | 0.172 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.766639e-01 | 0.170 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.778039e-01 | 0.169 |
| R-HSA-877300 | Interferon gamma signaling | 6.826851e-01 | 0.166 |
| R-HSA-5663205 | Infectious disease | 6.833094e-01 | 0.165 |
| R-HSA-9659379 | Sensory processing of sound | 6.862995e-01 | 0.163 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.904633e-01 | 0.161 |
| R-HSA-977225 | Amyloid fiber formation | 6.945721e-01 | 0.158 |
| R-HSA-9609646 | HCMV Infection | 6.975388e-01 | 0.156 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.065756e-01 | 0.151 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.065756e-01 | 0.151 |
| R-HSA-1500620 | Meiosis | 7.104715e-01 | 0.148 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.104715e-01 | 0.148 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.143159e-01 | 0.146 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.169132e-01 | 0.145 |
| R-HSA-72306 | tRNA processing | 7.169132e-01 | 0.145 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.181095e-01 | 0.144 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.181095e-01 | 0.144 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.196214e-01 | 0.143 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.255469e-01 | 0.139 |
| R-HSA-156902 | Peptide chain elongation | 7.255469e-01 | 0.139 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.291920e-01 | 0.137 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.432969e-01 | 0.129 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.432969e-01 | 0.129 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.432969e-01 | 0.129 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.432969e-01 | 0.129 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 7.533935e-01 | 0.123 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.533935e-01 | 0.123 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.566704e-01 | 0.121 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.576930e-01 | 0.121 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.599040e-01 | 0.119 |
| R-HSA-1296071 | Potassium Channels | 7.599040e-01 | 0.119 |
| R-HSA-157579 | Telomere Maintenance | 7.630948e-01 | 0.117 |
| R-HSA-422356 | Regulation of insulin secretion | 7.662434e-01 | 0.116 |
| R-HSA-3214847 | HATs acetylate histones | 7.693503e-01 | 0.114 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.693503e-01 | 0.114 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.716316e-01 | 0.113 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.754414e-01 | 0.110 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.754414e-01 | 0.110 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.784266e-01 | 0.109 |
| R-HSA-9679506 | SARS-CoV Infections | 7.800592e-01 | 0.108 |
| R-HSA-192823 | Viral mRNA Translation | 7.813724e-01 | 0.107 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.842791e-01 | 0.106 |
| R-HSA-9833110 | RSV-host interactions | 7.871474e-01 | 0.104 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.899777e-01 | 0.102 |
| R-HSA-428157 | Sphingolipid metabolism | 7.912330e-01 | 0.102 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.933172e-01 | 0.101 |
| R-HSA-211000 | Gene Silencing by RNA | 7.955265e-01 | 0.099 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.982459e-01 | 0.098 |
| R-HSA-202403 | TCR signaling | 8.035772e-01 | 0.095 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.035772e-01 | 0.095 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.087682e-01 | 0.092 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.087682e-01 | 0.092 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.087682e-01 | 0.092 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.187442e-01 | 0.087 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.258847e-01 | 0.083 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.304888e-01 | 0.081 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.393366e-01 | 0.076 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.430555e-01 | 0.074 |
| R-HSA-977606 | Regulation of Complement cascade | 8.435865e-01 | 0.074 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.456693e-01 | 0.073 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.456693e-01 | 0.073 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.456693e-01 | 0.073 |
| R-HSA-72766 | Translation | 8.508106e-01 | 0.070 |
| R-HSA-1474165 | Reproduction | 8.575991e-01 | 0.067 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.699933e-01 | 0.060 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.720895e-01 | 0.059 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.787744e-01 | 0.056 |
| R-HSA-1632852 | Macroautophagy | 8.787744e-01 | 0.056 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.851115e-01 | 0.053 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.856612e-01 | 0.053 |
| R-HSA-166658 | Complement cascade | 8.866436e-01 | 0.052 |
| R-HSA-2187338 | Visual phototransduction | 8.896470e-01 | 0.051 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.913781e-01 | 0.050 |
| R-HSA-416476 | G alpha (q) signalling events | 8.925320e-01 | 0.049 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.940042e-01 | 0.049 |
| R-HSA-9610379 | HCMV Late Events | 9.035165e-01 | 0.044 |
| R-HSA-9711097 | Cellular response to starvation | 9.048041e-01 | 0.043 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.153352e-01 | 0.038 |
| R-HSA-5619102 | SLC transporter disorders | 9.156499e-01 | 0.038 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.353797e-01 | 0.029 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.487368e-01 | 0.023 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.533696e-01 | 0.021 |
| R-HSA-9748784 | Drug ADME | 9.586836e-01 | 0.018 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.648602e-01 | 0.016 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.716900e-01 | 0.012 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.720693e-01 | 0.012 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.789741e-01 | 0.009 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.826042e-01 | 0.008 |
| R-HSA-500792 | GPCR ligand binding | 9.884707e-01 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 9.901581e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.927038e-01 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.942868e-01 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.960454e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.964055e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.968641e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.983020e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.999916e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999995e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.797 | 0.149 | 2 | 0.844 |
GRK1 |
0.790 | 0.174 | -2 | 0.736 |
DSTYK |
0.787 | 0.184 | 2 | 0.851 |
CAMK2G |
0.786 | 0.183 | 2 | 0.857 |
CK2A2 |
0.783 | 0.275 | 1 | 0.755 |
FAM20C |
0.783 | 0.103 | 2 | 0.610 |
GRK6 |
0.782 | 0.195 | 1 | 0.843 |
BMPR1B |
0.782 | 0.207 | 1 | 0.827 |
CDC7 |
0.781 | 0.035 | 1 | 0.881 |
TGFBR1 |
0.779 | 0.208 | -2 | 0.849 |
MOS |
0.779 | 0.078 | 1 | 0.889 |
IKKB |
0.778 | 0.033 | -2 | 0.699 |
IKKA |
0.777 | 0.090 | -2 | 0.698 |
CLK3 |
0.776 | 0.068 | 1 | 0.812 |
ALK2 |
0.775 | 0.241 | -2 | 0.852 |
PRPK |
0.775 | -0.008 | -1 | 0.384 |
CAMK2B |
0.775 | 0.165 | 2 | 0.833 |
BMPR1A |
0.774 | 0.212 | 1 | 0.819 |
GRK4 |
0.773 | 0.093 | -2 | 0.794 |
PLK1 |
0.770 | 0.136 | -2 | 0.844 |
NEK6 |
0.770 | 0.079 | -2 | 0.842 |
ATM |
0.770 | 0.076 | 1 | 0.748 |
PIM3 |
0.769 | 0.022 | -3 | 0.743 |
TBK1 |
0.769 | -0.013 | 1 | 0.767 |
BMPR2 |
0.769 | 0.010 | -2 | 0.859 |
RAF1 |
0.769 | -0.030 | 1 | 0.854 |
IKKE |
0.769 | 0.001 | 1 | 0.768 |
CK2A1 |
0.769 | 0.216 | 1 | 0.731 |
GRK7 |
0.768 | 0.127 | 1 | 0.764 |
ALK4 |
0.768 | 0.142 | -2 | 0.856 |
ACVR2A |
0.768 | 0.134 | -2 | 0.845 |
PLK3 |
0.767 | 0.130 | 2 | 0.775 |
ACVR2B |
0.767 | 0.136 | -2 | 0.852 |
NDR2 |
0.767 | 0.005 | -3 | 0.753 |
NEK7 |
0.766 | 0.009 | -3 | 0.809 |
GCN2 |
0.766 | -0.078 | 2 | 0.775 |
GRK5 |
0.765 | 0.005 | -3 | 0.831 |
MTOR |
0.763 | -0.106 | 1 | 0.773 |
CAMK2A |
0.763 | 0.107 | 2 | 0.860 |
ERK5 |
0.763 | -0.017 | 1 | 0.805 |
PDHK4 |
0.762 | -0.169 | 1 | 0.846 |
CAMK1B |
0.762 | -0.034 | -3 | 0.770 |
TGFBR2 |
0.761 | -0.013 | -2 | 0.848 |
KIS |
0.761 | 0.026 | 1 | 0.685 |
HUNK |
0.761 | -0.028 | 2 | 0.774 |
ULK2 |
0.760 | -0.107 | 2 | 0.746 |
PIM1 |
0.760 | 0.031 | -3 | 0.681 |
LATS2 |
0.759 | 0.019 | -5 | 0.750 |
ULK1 |
0.759 | -0.047 | -3 | 0.793 |
ATR |
0.757 | -0.067 | 1 | 0.804 |
MLK1 |
0.756 | -0.079 | 2 | 0.766 |
CAMK2D |
0.756 | 0.005 | -3 | 0.752 |
NLK |
0.756 | -0.098 | 1 | 0.810 |
PKN3 |
0.755 | -0.027 | -3 | 0.732 |
PDHK1 |
0.755 | -0.164 | 1 | 0.851 |
DNAPK |
0.754 | 0.080 | 1 | 0.692 |
SKMLCK |
0.754 | -0.038 | -2 | 0.763 |
BCKDK |
0.754 | -0.115 | -1 | 0.294 |
LATS1 |
0.754 | 0.040 | -3 | 0.761 |
RSK2 |
0.753 | -0.028 | -3 | 0.661 |
PLK2 |
0.753 | 0.106 | -3 | 0.769 |
DLK |
0.752 | -0.068 | 1 | 0.825 |
PRKD1 |
0.751 | -0.056 | -3 | 0.738 |
CDKL1 |
0.751 | -0.071 | -3 | 0.708 |
MAPKAPK2 |
0.750 | 0.020 | -3 | 0.615 |
NDR1 |
0.750 | -0.065 | -3 | 0.733 |
NIK |
0.750 | -0.130 | -3 | 0.801 |
RIPK3 |
0.749 | -0.154 | 3 | 0.722 |
CAMLCK |
0.749 | -0.069 | -2 | 0.768 |
MST4 |
0.748 | -0.092 | 2 | 0.783 |
GRK2 |
0.748 | 0.025 | -2 | 0.681 |
TTBK2 |
0.748 | -0.096 | 2 | 0.660 |
JNK3 |
0.747 | 0.026 | 1 | 0.641 |
NEK9 |
0.747 | -0.103 | 2 | 0.781 |
BRAF |
0.747 | 0.068 | -4 | 0.760 |
WNK1 |
0.747 | -0.115 | -2 | 0.766 |
CK1E |
0.747 | 0.053 | -3 | 0.646 |
NUAK2 |
0.746 | -0.099 | -3 | 0.738 |
TSSK2 |
0.746 | -0.037 | -5 | 0.765 |
JNK2 |
0.746 | 0.035 | 1 | 0.611 |
ANKRD3 |
0.746 | -0.133 | 1 | 0.845 |
CHAK2 |
0.746 | -0.114 | -1 | 0.345 |
MARK4 |
0.746 | -0.112 | 4 | 0.625 |
P70S6KB |
0.745 | -0.047 | -3 | 0.685 |
AMPKA1 |
0.745 | -0.090 | -3 | 0.759 |
DAPK2 |
0.745 | -0.119 | -3 | 0.780 |
P90RSK |
0.745 | -0.067 | -3 | 0.672 |
CDK8 |
0.745 | -0.038 | 1 | 0.657 |
TLK2 |
0.744 | -0.026 | 1 | 0.763 |
MASTL |
0.744 | -0.187 | -2 | 0.739 |
RSK4 |
0.743 | -0.006 | -3 | 0.632 |
WNK3 |
0.743 | -0.199 | 1 | 0.798 |
GRK3 |
0.743 | 0.046 | -2 | 0.641 |
GSK3A |
0.743 | 0.018 | 4 | 0.397 |
CLK2 |
0.742 | 0.035 | -3 | 0.639 |
SRPK1 |
0.742 | -0.036 | -3 | 0.652 |
PRKD2 |
0.742 | -0.064 | -3 | 0.664 |
PKACG |
0.742 | -0.060 | -2 | 0.650 |
AURA |
0.741 | 0.009 | -2 | 0.542 |
MLK4 |
0.741 | -0.066 | 2 | 0.686 |
TLK1 |
0.741 | 0.067 | -2 | 0.852 |
PKCD |
0.741 | -0.089 | 2 | 0.763 |
CDKL5 |
0.741 | -0.074 | -3 | 0.698 |
YSK4 |
0.741 | -0.070 | 1 | 0.788 |
MEKK3 |
0.740 | -0.026 | 1 | 0.797 |
PKR |
0.740 | -0.086 | 1 | 0.806 |
ICK |
0.740 | -0.083 | -3 | 0.750 |
MLK3 |
0.740 | -0.075 | 2 | 0.704 |
MAPKAPK3 |
0.740 | -0.071 | -3 | 0.667 |
MSK2 |
0.740 | -0.053 | -3 | 0.644 |
PKN2 |
0.740 | -0.105 | -3 | 0.737 |
MEK1 |
0.739 | -0.121 | 2 | 0.802 |
SRPK2 |
0.739 | -0.027 | -3 | 0.565 |
CK1D |
0.739 | 0.059 | -3 | 0.604 |
RSK3 |
0.738 | -0.082 | -3 | 0.653 |
PASK |
0.738 | 0.025 | -3 | 0.772 |
CDK1 |
0.737 | -0.003 | 1 | 0.610 |
MSK1 |
0.737 | -0.025 | -3 | 0.637 |
PRKX |
0.737 | 0.012 | -3 | 0.550 |
IRE2 |
0.737 | -0.062 | 2 | 0.717 |
TSSK1 |
0.736 | -0.096 | -3 | 0.783 |
MLK2 |
0.736 | -0.177 | 2 | 0.763 |
NIM1 |
0.736 | -0.140 | 3 | 0.745 |
SRPK3 |
0.736 | -0.039 | -3 | 0.626 |
AMPKA2 |
0.736 | -0.098 | -3 | 0.715 |
PLK4 |
0.735 | -0.087 | 2 | 0.602 |
GSK3B |
0.735 | -0.027 | 4 | 0.381 |
PAK1 |
0.735 | -0.065 | -2 | 0.677 |
PRP4 |
0.735 | 0.034 | -3 | 0.784 |
AURC |
0.735 | -0.054 | -2 | 0.575 |
CAMK4 |
0.734 | -0.106 | -3 | 0.718 |
DRAK1 |
0.734 | -0.055 | 1 | 0.740 |
CK1A2 |
0.734 | 0.046 | -3 | 0.597 |
P38B |
0.734 | -0.004 | 1 | 0.630 |
HIPK4 |
0.734 | -0.097 | 1 | 0.738 |
CLK4 |
0.734 | -0.040 | -3 | 0.657 |
CDK19 |
0.733 | -0.052 | 1 | 0.619 |
DYRK2 |
0.733 | -0.036 | 1 | 0.664 |
P38A |
0.733 | -0.021 | 1 | 0.692 |
P38G |
0.733 | 0.004 | 1 | 0.532 |
NEK2 |
0.732 | -0.105 | 2 | 0.749 |
PKACB |
0.732 | -0.023 | -2 | 0.594 |
RIPK1 |
0.732 | -0.250 | 1 | 0.772 |
CK1G1 |
0.732 | 0.005 | -3 | 0.627 |
VRK2 |
0.732 | -0.276 | 1 | 0.849 |
IRE1 |
0.731 | -0.187 | 1 | 0.740 |
CDK7 |
0.730 | -0.072 | 1 | 0.663 |
HRI |
0.730 | -0.099 | -2 | 0.843 |
SMG1 |
0.730 | -0.115 | 1 | 0.748 |
MEKK1 |
0.730 | -0.085 | 1 | 0.811 |
MARK2 |
0.730 | -0.094 | 4 | 0.546 |
BRSK1 |
0.729 | -0.076 | -3 | 0.680 |
CDK2 |
0.729 | -0.036 | 1 | 0.688 |
ZAK |
0.729 | -0.105 | 1 | 0.789 |
CDK5 |
0.729 | -0.036 | 1 | 0.675 |
NUAK1 |
0.728 | -0.117 | -3 | 0.673 |
MEKK2 |
0.728 | -0.078 | 2 | 0.761 |
GAK |
0.728 | 0.004 | 1 | 0.849 |
MYLK4 |
0.728 | -0.079 | -2 | 0.685 |
PERK |
0.728 | -0.118 | -2 | 0.847 |
CDK18 |
0.728 | -0.044 | 1 | 0.588 |
JNK1 |
0.728 | 0.011 | 1 | 0.594 |
CAMKK1 |
0.728 | -0.007 | -2 | 0.725 |
P38D |
0.727 | 0.009 | 1 | 0.557 |
ERK1 |
0.727 | -0.037 | 1 | 0.618 |
CLK1 |
0.727 | -0.051 | -3 | 0.625 |
ERK2 |
0.727 | -0.054 | 1 | 0.645 |
PKCB |
0.727 | -0.102 | 2 | 0.703 |
CDK13 |
0.727 | -0.055 | 1 | 0.633 |
CHK1 |
0.727 | -0.077 | -3 | 0.720 |
PAK3 |
0.727 | -0.127 | -2 | 0.681 |
MNK2 |
0.726 | -0.107 | -2 | 0.700 |
PAK2 |
0.726 | -0.102 | -2 | 0.659 |
NEK5 |
0.726 | -0.100 | 1 | 0.802 |
DYRK4 |
0.726 | 0.000 | 1 | 0.601 |
AURB |
0.725 | -0.069 | -2 | 0.567 |
MARK3 |
0.725 | -0.097 | 4 | 0.561 |
PKCG |
0.724 | -0.122 | 2 | 0.702 |
PKCA |
0.724 | -0.111 | 2 | 0.692 |
TAO3 |
0.724 | -0.101 | 1 | 0.792 |
CDK17 |
0.724 | -0.040 | 1 | 0.534 |
ALPHAK3 |
0.723 | 0.094 | -1 | 0.426 |
QSK |
0.723 | -0.128 | 4 | 0.590 |
CDK3 |
0.723 | -0.003 | 1 | 0.557 |
CDK16 |
0.723 | -0.015 | 1 | 0.553 |
PRKD3 |
0.723 | -0.099 | -3 | 0.628 |
PIM2 |
0.723 | -0.047 | -3 | 0.628 |
MELK |
0.723 | -0.137 | -3 | 0.694 |
MNK1 |
0.722 | -0.103 | -2 | 0.719 |
SGK3 |
0.722 | -0.072 | -3 | 0.639 |
SIK |
0.722 | -0.124 | -3 | 0.648 |
PKCH |
0.721 | -0.125 | 2 | 0.689 |
CHAK1 |
0.721 | -0.203 | 2 | 0.685 |
TTBK1 |
0.721 | -0.124 | 2 | 0.595 |
PINK1 |
0.721 | -0.122 | 1 | 0.782 |
QIK |
0.721 | -0.201 | -3 | 0.738 |
MEK5 |
0.721 | -0.237 | 2 | 0.777 |
MAPKAPK5 |
0.721 | -0.117 | -3 | 0.610 |
MARK1 |
0.720 | -0.116 | 4 | 0.581 |
PKG2 |
0.720 | -0.080 | -2 | 0.594 |
SSTK |
0.718 | -0.085 | 4 | 0.572 |
MST2 |
0.718 | -0.058 | 1 | 0.819 |
EEF2K |
0.718 | -0.014 | 3 | 0.781 |
DCAMKL1 |
0.718 | -0.107 | -3 | 0.672 |
MST3 |
0.718 | -0.124 | 2 | 0.770 |
CAMK1G |
0.718 | -0.103 | -3 | 0.651 |
CAMKK2 |
0.718 | -0.053 | -2 | 0.710 |
NEK8 |
0.717 | -0.109 | 2 | 0.768 |
CDK12 |
0.717 | -0.061 | 1 | 0.605 |
HIPK2 |
0.717 | -0.042 | 1 | 0.578 |
HIPK1 |
0.717 | -0.060 | 1 | 0.683 |
PKCZ |
0.717 | -0.164 | 2 | 0.728 |
PHKG1 |
0.717 | -0.164 | -3 | 0.730 |
BRSK2 |
0.717 | -0.154 | -3 | 0.712 |
PKACA |
0.717 | -0.036 | -2 | 0.548 |
PAK6 |
0.717 | -0.099 | -2 | 0.599 |
AKT2 |
0.717 | -0.076 | -3 | 0.569 |
LKB1 |
0.716 | -0.076 | -3 | 0.806 |
TAK1 |
0.716 | -0.075 | 1 | 0.822 |
SMMLCK |
0.716 | -0.097 | -3 | 0.714 |
SNRK |
0.715 | -0.178 | 2 | 0.653 |
IRAK1 |
0.715 | -0.217 | -1 | 0.273 |
CDK9 |
0.715 | -0.077 | 1 | 0.640 |
WNK4 |
0.715 | -0.181 | -2 | 0.746 |
DYRK1B |
0.715 | -0.040 | 1 | 0.622 |
DYRK1A |
0.715 | -0.066 | 1 | 0.709 |
CAMK1D |
0.714 | -0.051 | -3 | 0.564 |
IRAK4 |
0.713 | -0.206 | 1 | 0.762 |
DAPK3 |
0.713 | -0.063 | -3 | 0.694 |
DCAMKL2 |
0.713 | -0.106 | -3 | 0.695 |
TAO2 |
0.713 | -0.140 | 2 | 0.806 |
NEK11 |
0.713 | -0.190 | 1 | 0.789 |
CDK14 |
0.712 | -0.066 | 1 | 0.631 |
GCK |
0.712 | -0.091 | 1 | 0.800 |
P70S6K |
0.711 | -0.085 | -3 | 0.583 |
MPSK1 |
0.710 | -0.118 | 1 | 0.764 |
ERK7 |
0.710 | -0.042 | 2 | 0.508 |
PDHK3_TYR |
0.709 | 0.163 | 4 | 0.729 |
DAPK1 |
0.709 | -0.062 | -3 | 0.680 |
MST1 |
0.708 | -0.076 | 1 | 0.796 |
TTK |
0.708 | 0.000 | -2 | 0.851 |
PDHK1_TYR |
0.707 | 0.246 | -1 | 0.471 |
NEK4 |
0.707 | -0.158 | 1 | 0.781 |
DYRK3 |
0.707 | -0.068 | 1 | 0.682 |
MAP2K6_TYR |
0.706 | 0.174 | -1 | 0.426 |
MINK |
0.706 | -0.133 | 1 | 0.799 |
TNIK |
0.706 | -0.091 | 3 | 0.771 |
HIPK3 |
0.706 | -0.097 | 1 | 0.690 |
PDK1 |
0.705 | -0.154 | 1 | 0.779 |
CK1A |
0.705 | 0.028 | -3 | 0.525 |
AKT1 |
0.705 | -0.086 | -3 | 0.583 |
PKCT |
0.704 | -0.153 | 2 | 0.696 |
PDHK4_TYR |
0.703 | 0.102 | 2 | 0.853 |
NEK1 |
0.703 | -0.139 | 1 | 0.780 |
PHKG2 |
0.703 | -0.153 | -3 | 0.681 |
MAP3K15 |
0.702 | -0.191 | 1 | 0.771 |
BMPR2_TYR |
0.702 | 0.056 | -1 | 0.434 |
CDK10 |
0.702 | -0.065 | 1 | 0.614 |
SGK1 |
0.702 | -0.043 | -3 | 0.482 |
VRK1 |
0.701 | -0.199 | 2 | 0.802 |
HGK |
0.700 | -0.162 | 3 | 0.773 |
EPHA6 |
0.700 | 0.079 | -1 | 0.444 |
HPK1 |
0.700 | -0.131 | 1 | 0.790 |
PAK5 |
0.699 | -0.113 | -2 | 0.526 |
OSR1 |
0.698 | -0.045 | 2 | 0.740 |
MRCKA |
0.698 | -0.063 | -3 | 0.631 |
MEKK6 |
0.698 | -0.232 | 1 | 0.793 |
MAP2K4_TYR |
0.698 | 0.041 | -1 | 0.405 |
LRRK2 |
0.698 | -0.231 | 2 | 0.795 |
RIPK2 |
0.698 | -0.192 | 1 | 0.755 |
PAK4 |
0.697 | -0.103 | -2 | 0.538 |
STK33 |
0.697 | -0.137 | 2 | 0.588 |
CDK6 |
0.697 | -0.061 | 1 | 0.615 |
EPHA4 |
0.697 | 0.095 | 2 | 0.773 |
PKCI |
0.696 | -0.157 | 2 | 0.697 |
YANK3 |
0.696 | -0.032 | 2 | 0.396 |
MEK2 |
0.696 | -0.214 | 2 | 0.759 |
INSRR |
0.695 | 0.097 | 3 | 0.709 |
EPHB4 |
0.695 | 0.047 | -1 | 0.405 |
TXK |
0.695 | 0.032 | 1 | 0.863 |
FER |
0.695 | 0.060 | 1 | 0.885 |
PKCE |
0.694 | -0.120 | 2 | 0.682 |
MRCKB |
0.694 | -0.079 | -3 | 0.614 |
KHS1 |
0.694 | -0.114 | 1 | 0.789 |
ROCK2 |
0.694 | -0.079 | -3 | 0.673 |
KHS2 |
0.694 | -0.094 | 1 | 0.795 |
CDK4 |
0.694 | -0.060 | 1 | 0.591 |
BIKE |
0.693 | -0.003 | 1 | 0.745 |
PBK |
0.693 | -0.073 | 1 | 0.789 |
EPHB2 |
0.693 | 0.083 | -1 | 0.413 |
MAK |
0.693 | -0.054 | -2 | 0.639 |
SLK |
0.693 | -0.142 | -2 | 0.638 |
SRMS |
0.693 | 0.031 | 1 | 0.873 |
MAP2K7_TYR |
0.692 | -0.101 | 2 | 0.828 |
AKT3 |
0.692 | -0.074 | -3 | 0.505 |
LOK |
0.692 | -0.172 | -2 | 0.696 |
DMPK1 |
0.692 | -0.051 | -3 | 0.635 |
TESK1_TYR |
0.692 | -0.077 | 3 | 0.823 |
SBK |
0.691 | -0.055 | -3 | 0.442 |
CAMK1A |
0.690 | -0.087 | -3 | 0.524 |
EPHB1 |
0.690 | 0.030 | 1 | 0.871 |
BLK |
0.690 | 0.065 | -1 | 0.423 |
YSK1 |
0.690 | -0.167 | 2 | 0.747 |
PINK1_TYR |
0.690 | -0.058 | 1 | 0.817 |
CK1G3 |
0.690 | 0.034 | -3 | 0.477 |
EPHB3 |
0.689 | 0.053 | -1 | 0.399 |
YES1 |
0.689 | -0.011 | -1 | 0.354 |
SYK |
0.688 | 0.120 | -1 | 0.479 |
FGR |
0.688 | 0.084 | 1 | 0.852 |
ASK1 |
0.688 | -0.127 | 1 | 0.764 |
PKMYT1_TYR |
0.687 | -0.145 | 3 | 0.797 |
FYN |
0.687 | 0.028 | -1 | 0.378 |
CHK2 |
0.687 | -0.113 | -3 | 0.505 |
HASPIN |
0.687 | -0.111 | -1 | 0.253 |
BMX |
0.687 | -0.022 | -1 | 0.328 |
ABL2 |
0.686 | 0.011 | -1 | 0.405 |
PKN1 |
0.686 | -0.127 | -3 | 0.602 |
RET |
0.686 | -0.032 | 1 | 0.795 |
JAK3 |
0.686 | 0.036 | 1 | 0.776 |
CK1G2 |
0.686 | 0.064 | -3 | 0.559 |
EPHA5 |
0.685 | 0.079 | 2 | 0.768 |
FLT1 |
0.685 | 0.096 | -1 | 0.496 |
FGFR2 |
0.684 | 0.019 | 3 | 0.761 |
EGFR |
0.684 | 0.079 | 1 | 0.678 |
HCK |
0.684 | -0.038 | -1 | 0.378 |
LCK |
0.684 | -0.006 | -1 | 0.396 |
EPHA7 |
0.684 | 0.031 | 2 | 0.769 |
KIT |
0.683 | -0.007 | 3 | 0.738 |
CSF1R |
0.683 | -0.045 | 3 | 0.728 |
BUB1 |
0.683 | -0.114 | -5 | 0.707 |
MOK |
0.683 | -0.089 | 1 | 0.691 |
ITK |
0.682 | -0.053 | -1 | 0.343 |
TYK2 |
0.682 | -0.099 | 1 | 0.804 |
NEK3 |
0.681 | -0.218 | 1 | 0.757 |
CRIK |
0.681 | -0.063 | -3 | 0.582 |
STLK3 |
0.681 | -0.094 | 1 | 0.759 |
JAK2 |
0.680 | -0.059 | 1 | 0.806 |
ROS1 |
0.680 | -0.074 | 3 | 0.710 |
TEC |
0.680 | -0.079 | -1 | 0.291 |
EPHA3 |
0.680 | -0.012 | 2 | 0.749 |
DDR1 |
0.679 | -0.110 | 4 | 0.651 |
FGFR3 |
0.679 | 0.037 | 3 | 0.739 |
FGFR4 |
0.679 | 0.061 | -1 | 0.426 |
EPHA8 |
0.679 | 0.052 | -1 | 0.441 |
TYRO3 |
0.679 | -0.154 | 3 | 0.732 |
ABL1 |
0.679 | -0.041 | -1 | 0.383 |
MST1R |
0.679 | -0.125 | 3 | 0.744 |
ROCK1 |
0.679 | -0.091 | -3 | 0.631 |
PTK2 |
0.678 | 0.021 | -1 | 0.401 |
ERBB2 |
0.678 | 0.011 | 1 | 0.762 |
PKG1 |
0.677 | -0.110 | -2 | 0.526 |
MYO3A |
0.677 | -0.147 | 1 | 0.757 |
NTRK1 |
0.677 | -0.028 | -1 | 0.371 |
MET |
0.677 | -0.034 | 3 | 0.715 |
TAO1 |
0.676 | -0.165 | 1 | 0.728 |
MERTK |
0.676 | -0.067 | 3 | 0.723 |
FLT3 |
0.676 | -0.048 | 3 | 0.723 |
EPHA2 |
0.676 | 0.054 | -1 | 0.427 |
LYN |
0.675 | -0.032 | 3 | 0.672 |
KDR |
0.675 | -0.036 | 3 | 0.709 |
MATK |
0.675 | 0.014 | -1 | 0.416 |
FRK |
0.675 | 0.017 | -1 | 0.446 |
FGFR1 |
0.674 | -0.044 | 3 | 0.729 |
LIMK2_TYR |
0.674 | -0.183 | -3 | 0.823 |
AAK1 |
0.674 | 0.008 | 1 | 0.649 |
MYO3B |
0.673 | -0.162 | 2 | 0.754 |
TEK |
0.673 | -0.065 | 3 | 0.691 |
FLT4 |
0.673 | 0.005 | 3 | 0.721 |
PDGFRB |
0.673 | -0.092 | 3 | 0.742 |
LIMK1_TYR |
0.673 | -0.248 | 2 | 0.808 |
CSK |
0.672 | 0.019 | 2 | 0.769 |
NTRK3 |
0.672 | -0.026 | -1 | 0.367 |
ERBB4 |
0.672 | 0.060 | 1 | 0.702 |
SRC |
0.672 | -0.026 | -1 | 0.369 |
LTK |
0.671 | -0.073 | 3 | 0.699 |
INSR |
0.670 | -0.059 | 3 | 0.681 |
IGF1R |
0.670 | 0.014 | 3 | 0.633 |
AXL |
0.670 | -0.131 | 3 | 0.727 |
BTK |
0.669 | -0.174 | -1 | 0.292 |
ALK |
0.668 | -0.091 | 3 | 0.671 |
PTK6 |
0.668 | -0.142 | -1 | 0.297 |
TNK2 |
0.668 | -0.140 | 3 | 0.702 |
PTK2B |
0.667 | -0.070 | -1 | 0.302 |
JAK1 |
0.667 | -0.080 | 1 | 0.755 |
YANK2 |
0.666 | -0.047 | 2 | 0.417 |
NTRK2 |
0.666 | -0.112 | 3 | 0.705 |
NEK10_TYR |
0.664 | -0.109 | 1 | 0.682 |
EPHA1 |
0.662 | -0.126 | 3 | 0.698 |
DDR2 |
0.662 | -0.061 | 3 | 0.706 |
TNNI3K_TYR |
0.661 | -0.073 | 1 | 0.810 |
PDGFRA |
0.659 | -0.168 | 3 | 0.735 |
WEE1_TYR |
0.659 | -0.154 | -1 | 0.305 |
TNK1 |
0.655 | -0.206 | 3 | 0.712 |
ZAP70 |
0.651 | -0.011 | -1 | 0.394 |
FES |
0.650 | -0.083 | -1 | 0.301 |
MUSK |
0.649 | -0.060 | 1 | 0.659 |