Motif 607 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0PJX4 | SHISA3 | S137 | ochoa | Protein shisa-3 homolog | Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. {ECO:0000250}. |
| A2RU30 | TESPA1 | S311 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
| A6NNZ2 | TUBB8B | Y281 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| A8MVW0 | FAM171A2 | S664 | ochoa | Protein FAM171A2 | None |
| O00273 | DFFA | S254 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O14867 | BACH1 | S388 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
| O15061 | SYNM | S1141 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43541 | SMAD6 | S435 | psp | Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) | Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:16951688, PubMed:22275001, PubMed:30848080, PubMed:9436979, PubMed:9759503). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:30848080, PubMed:9436979). Binds to regulatory elements in target promoter regions (PubMed:16491121). {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:22275001, ECO:0000269|PubMed:30848080, ECO:0000269|PubMed:9436979, ECO:0000303|PubMed:10647776, ECO:0000303|PubMed:10708948, ECO:0000303|PubMed:10708949, ECO:0000303|PubMed:9759503}. |
| O43613 | HCRTR1 | S262 | psp | Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897). {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}. |
| O60469 | DSCAM | S1934 | ochoa | Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}. |
| O60496 | DOK2 | S63 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| P04083 | ANXA1 | S189 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04350 | TUBB4A | Y281 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | Y281 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10451 | SPP1 | S219 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10636 | MAPT | S46 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10636 | MAPT | S341 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P12268 | IMPDH2 | S426 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P25705 | ATP5F1A | S462 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P29374 | ARID4A | S1076 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30405 | PPIF | S123 | ochoa|psp | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| P32929 | CTH | S377 | psp | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| P33981 | TTK | S393 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35609 | ACTN2 | S574 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35711 | SOX5 | S120 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P35749 | MYH11 | S1291 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38432 | COIL | S271 | ochoa|psp | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P39748 | FEN1 | S352 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P41208 | CETN2 | S20 | ochoa | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P41235 | HNF4A | S138 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42166 | TMPO | S497 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P46013 | MKI67 | S2925 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48444 | ARCN1 | S195 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P50454 | SERPINH1 | S150 | ochoa | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| P56182 | RRP1 | S291 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P56182 | RRP1 | S315 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P60228 | EIF3E | S399 | ochoa | Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P61587 | RND3 | S218 | psp | Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3) | Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. |
| P68371 | TUBB4B | Y281 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78536 | ADAM17 | S786 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| Q00536 | CDK16 | S65 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00537 | CDK17 | S92 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q04637 | EIF4G1 | S1092 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05209 | PTPN12 | S613 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q09470 | KCNA1 | S446 | psp | Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818, PubMed:8845167). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19307729, PubMed:19903818, PubMed:19912772, PubMed:19968958). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:19307729, PubMed:23903368). {ECO:0000250|UniProtKB:P10499, ECO:0000269|PubMed:11026449, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:15837928, ECO:0000269|PubMed:17136396, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19307729, ECO:0000269|PubMed:19903818, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:21106501, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:8845167}. |
| Q13098 | GPS1 | S240 | ochoa | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q13136 | PPFIA1 | S239 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13308 | PTK7 | S795 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13415 | ORC1 | S346 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13596 | SNX1 | S72 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13885 | TUBB2A | Y281 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q13936 | CACNA1C | S1718 | ochoa | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q14151 | SAFB2 | S321 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14847 | LASP1 | S82 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14980 | NUMA1 | S1901 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15036 | SNX17 | S38 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15424 | SAFB | S322 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16665 | HIF1A | S696 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16825 | PTPN21 | S480 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q3ZCM7 | TUBB8 | Y281 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q53HL2 | CDCA8 | S250 | ochoa | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q6FI81 | CIAPIN1 | S215 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6IAA8 | LAMTOR1 | S73 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6NSZ9 | ZSCAN25 | S267 | ochoa | Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6NZY4 | ZCCHC8 | S573 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6PGN9 | PSRC1 | S65 | ochoa|psp | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6ZRV2 | FAM83H | S785 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZS30 | NBEAL1 | S315 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q765P7 | MTSS2 | S428 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7Z591 | AKNA | S935 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86U86 | PBRM1 | S316 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UD0 | SAPCD2 | S152 | ochoa | Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) | Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}. |
| Q86UW6 | N4BP2 | S854 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86VF7 | NRAP | S152 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q8IVL1 | NAV2 | S2365 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IW41 | MAPKAPK5 | S115 | psp | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IYI6 | EXOC8 | S32 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8N1K5 | THEMIS | S611 | ochoa | Protein THEMIS (Thymocyte-expressed molecule involved in selection) | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000250|UniProtKB:Q8BGW0}. |
| Q8N2F6 | ARMC10 | S43 | ochoa | Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) | May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}. |
| Q8N5P1 | ZC3H8 | S86 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8N960 | CEP120 | S426 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
| Q8NDX1 | PSD4 | S413 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFX7 | STXBP6 | S78 | ochoa | Syntaxin-binding protein 6 (Amisyn) | Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. |
| Q8TAA9 | VANGL1 | S96 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TB24 | RIN3 | S875 | ochoa | Ras and Rab interactor 3 (Ras interaction/interference protein 3) | Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}. |
| Q8TDD1 | DDX54 | S34 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8WUI4 | HDAC7 | S464 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WUY9 | DEPDC1B | S160 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
| Q8WW12 | PCNP | S108 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WZ75 | ROBO4 | S891 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92545 | TMEM131 | S1345 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92785 | DPF2 | S113 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92786 | PROX1 | S291 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92859 | NEO1 | S1294 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q93009 | USP7 | S49 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96CF2 | CHMP4C | S210 | psp | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}. |
| Q96L91 | EP400 | S2086 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96Q27 | ASB2 | S371 | psp | Ankyrin repeat and SOCS box protein 2 (ASB-2) | Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15590664, PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed:32179481). Specifically promotes the ubiquitination of SMAD9 and targets it for proteasomal degradation, leading to avoid excessive accumulation of SMAD9 (PubMed:34845242). Plays a role in the regulation of NK-cell migration by modulating protein levels of filamin A/FLNA via regulation of its ubiquitination and proteasome degradation (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:15590664, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:21119685, ECO:0000269|PubMed:32179481, ECO:0000269|PubMed:34845242}.; FUNCTION: [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:19300455). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:19300455}.; FUNCTION: [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:21737450, PubMed:22916308, PubMed:24044920, PubMed:24052262). This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed:21737450). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed:22916308). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:21737450, ECO:0000269|PubMed:22916308, ECO:0000269|PubMed:24044920, ECO:0000269|PubMed:24052262}. |
| Q96RV3 | PCNX1 | S752 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q99523 | SORT1 | S793 | ochoa|psp | Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}. |
| Q9BUF5 | TUBB6 | Y281 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | Y281 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9C0J8 | WDR33 | S266 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9H1A4 | ANAPC1 | S1347 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H2P0 | ADNP | S997 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H9Q4 | NHEJ1 | S251 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HDC5 | JPH1 | S162 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQ31 | AKIP1 | S144 | ochoa | A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3) | Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269|PubMed:18178962, ECO:0000269|PubMed:20562110}. |
| Q9NR12 | PDLIM7 | S78 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR30 | DDX21 | S592 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NRM7 | LATS2 | S83 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NRY2 | INIP | S50 | ochoa | SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Q9NUQ6 | SPATS2L | S526 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NX24 | NHP2 | S19 | ochoa | H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}. |
| Q9P1Y6 | PHRF1 | S950 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P219 | CCDC88C | S1887 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UJ90 | KCNE5 | S95 | ochoa | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein) | Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}. |
| Q9UKL0 | RCOR1 | S127 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9ULV3 | CIZ1 | S265 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UQE7 | SMC3 | S383 | psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y333 | LSM2 | S65 | ochoa | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| Q9Y6K8 | AK5 | S504 | ochoa | Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) | Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}. |
| Q9Y6R0 | NUMBL | S228 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| P38646 | HSPA9 | S549 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| O75369 | FLNB | S2492 | Sugiyama | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O43264 | ZW10 | S605 | Sugiyama | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| Q00610 | CLTC | S576 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9GZM8 | NDEL1 | S251 | GPS6|SIGNOR | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9NRX4 | PHPT1 | S80 | Sugiyama | 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) | Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}. |
| Q02809 | PLOD1 | S346 | Sugiyama | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). {ECO:0000250|UniProtKB:Q9R0E2, ECO:0000269|PubMed:10686424, ECO:0000269|PubMed:15854030, ECO:0000269|PubMed:8621606, ECO:0000305}. |
| P62277 | RPS13 | S21 | Sugiyama | Small ribosomal subunit protein uS15 (40S ribosomal protein S13) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q969S3 | ZNF622 | S38 | Sugiyama | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q9BQ04 | RBM4B | S338 | Sugiyama | RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30) | Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). {ECO:0000250}. |
| Q9BWF3 | RBM4 | S343 | Sugiyama | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q8WX92 | NELFB | S542 | Sugiyama | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
| Q9Y265 | RUVBL1 | S179 | Sugiyama | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681). {ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11027681, ECO:0000269|PubMed:14506706, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:33205750}. |
| Q9Y6E0 | STK24 | S391 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.868947e-10 | 9.412 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.217105e-09 | 8.493 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.095352e-09 | 8.388 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.542801e-09 | 8.256 |
| R-HSA-68882 | Mitotic Anaphase | 2.619803e-08 | 7.582 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.767126e-08 | 7.558 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.242676e-08 | 7.489 |
| R-HSA-68877 | Mitotic Prometaphase | 4.894461e-08 | 7.310 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.263015e-08 | 7.279 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.941034e-08 | 7.100 |
| R-HSA-190828 | Gap junction trafficking | 8.250974e-08 | 7.083 |
| R-HSA-437239 | Recycling pathway of L1 | 1.259489e-07 | 6.900 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.647540e-07 | 6.783 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.822146e-07 | 6.739 |
| R-HSA-68886 | M Phase | 1.988797e-07 | 6.701 |
| R-HSA-190861 | Gap junction assembly | 2.720266e-07 | 6.565 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.655406e-07 | 6.332 |
| R-HSA-1640170 | Cell Cycle | 4.462184e-07 | 6.350 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.883124e-07 | 6.230 |
| R-HSA-9646399 | Aggrephagy | 6.724548e-07 | 6.172 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.809749e-07 | 6.167 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.843750e-07 | 6.105 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.888025e-06 | 5.724 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.893704e-06 | 5.723 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.857387e-06 | 5.731 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.896693e-06 | 5.722 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.230086e-06 | 5.652 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.938238e-06 | 5.532 |
| R-HSA-9833482 | PKR-mediated signaling | 4.076202e-06 | 5.390 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.564210e-06 | 5.341 |
| R-HSA-1632852 | Macroautophagy | 6.152879e-06 | 5.211 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 6.828841e-06 | 5.166 |
| R-HSA-983189 | Kinesins | 7.466657e-06 | 5.127 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.992603e-06 | 5.046 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.388083e-05 | 4.858 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.352145e-05 | 4.869 |
| R-HSA-9612973 | Autophagy | 1.405525e-05 | 4.852 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.519879e-05 | 4.818 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.631091e-05 | 4.788 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.655119e-05 | 4.781 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.464635e-05 | 4.608 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.395668e-05 | 4.357 |
| R-HSA-373760 | L1CAM interactions | 6.455518e-05 | 4.190 |
| R-HSA-5617833 | Cilium Assembly | 6.491314e-05 | 4.188 |
| R-HSA-9663891 | Selective autophagy | 7.019772e-05 | 4.154 |
| R-HSA-422475 | Axon guidance | 7.477344e-05 | 4.126 |
| R-HSA-9675108 | Nervous system development | 1.588219e-04 | 3.799 |
| R-HSA-199991 | Membrane Trafficking | 1.793708e-04 | 3.746 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.126543e-04 | 3.672 |
| R-HSA-5620924 | Intraflagellar transport | 2.989980e-04 | 3.524 |
| R-HSA-69275 | G2/M Transition | 2.834049e-04 | 3.548 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.040209e-04 | 3.517 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.225777e-04 | 3.491 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.554848e-04 | 3.342 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.915735e-04 | 3.308 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.846862e-04 | 3.165 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.205981e-04 | 3.036 |
| R-HSA-9609646 | HCMV Infection | 1.937412e-03 | 2.713 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.076512e-03 | 2.683 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.102127e-03 | 2.677 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.900347e-03 | 2.538 |
| R-HSA-913531 | Interferon Signaling | 3.051707e-03 | 2.515 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.201232e-03 | 2.495 |
| R-HSA-391251 | Protein folding | 4.130061e-03 | 2.384 |
| R-HSA-2262752 | Cellular responses to stress | 4.707361e-03 | 2.327 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 4.821436e-03 | 2.317 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.862979e-03 | 2.232 |
| R-HSA-186712 | Regulation of beta-cell development | 5.138305e-03 | 2.289 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.395689e-03 | 2.268 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.281071e-03 | 2.202 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.281071e-03 | 2.202 |
| R-HSA-9609690 | HCMV Early Events | 6.850310e-03 | 2.164 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.241004e-03 | 2.140 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.932751e-03 | 2.101 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.218583e-03 | 2.085 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.238536e-03 | 2.084 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.845073e-03 | 2.007 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 9.440735e-03 | 2.025 |
| R-HSA-380287 | Centrosome maturation | 1.068712e-02 | 1.971 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.112505e-02 | 1.954 |
| R-HSA-112316 | Neuronal System | 1.200065e-02 | 1.921 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.504770e-02 | 1.823 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.639735e-02 | 1.785 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.804926e-02 | 1.744 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.976848e-02 | 1.704 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.911673e-02 | 1.719 |
| R-HSA-75153 | Apoptotic execution phase | 1.824817e-02 | 1.739 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.099671e-02 | 1.678 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.340282e-02 | 1.631 |
| R-HSA-9831926 | Nephron development | 2.340282e-02 | 1.631 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.340282e-02 | 1.631 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.499526e-02 | 1.602 |
| R-HSA-72649 | Translation initiation complex formation | 2.605449e-02 | 1.584 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.824434e-02 | 1.549 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.052909e-02 | 1.515 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 3.009404e-02 | 1.522 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.754920e-02 | 1.560 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.247871e-02 | 1.488 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.356333e-02 | 1.474 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.356333e-02 | 1.474 |
| R-HSA-180786 | Extension of Telomeres | 3.170694e-02 | 1.499 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.290835e-02 | 1.483 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.290835e-02 | 1.483 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.290835e-02 | 1.483 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.290835e-02 | 1.483 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.290835e-02 | 1.483 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.290835e-02 | 1.483 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.356333e-02 | 1.474 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.512499e-02 | 1.454 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.512499e-02 | 1.454 |
| R-HSA-376172 | DSCAM interactions | 3.992398e-02 | 1.399 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.034068e-02 | 1.394 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.034068e-02 | 1.394 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.482628e-02 | 1.348 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.482628e-02 | 1.348 |
| R-HSA-8949613 | Cristae formation | 4.512047e-02 | 1.346 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.512047e-02 | 1.346 |
| R-HSA-9824446 | Viral Infection Pathways | 4.545936e-02 | 1.342 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.758501e-02 | 1.323 |
| R-HSA-5620971 | Pyroptosis | 4.758501e-02 | 1.323 |
| R-HSA-162582 | Signal Transduction | 4.936481e-02 | 1.307 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.965490e-02 | 1.304 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 5.009766e-02 | 1.300 |
| R-HSA-9615710 | Late endosomal microautophagy | 5.009766e-02 | 1.300 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.855540e-02 | 1.164 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.526246e-02 | 1.258 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.171626e-02 | 1.210 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 5.928778e-02 | 1.227 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.618303e-02 | 1.179 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.369815e-02 | 1.270 |
| R-HSA-4839726 | Chromatin organization | 5.838755e-02 | 1.234 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.265721e-02 | 1.279 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.791223e-02 | 1.237 |
| R-HSA-1266738 | Developmental Biology | 6.615151e-02 | 1.179 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 7.178910e-02 | 1.144 |
| R-HSA-8853659 | RET signaling | 7.178910e-02 | 1.144 |
| R-HSA-69205 | G1/S-Specific Transcription | 7.178910e-02 | 1.144 |
| R-HSA-8941326 | RUNX2 regulates bone development | 7.178910e-02 | 1.144 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.208557e-02 | 1.142 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.208557e-02 | 1.142 |
| R-HSA-6807070 | PTEN Regulation | 7.633406e-02 | 1.117 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.826337e-02 | 1.106 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 7.826337e-02 | 1.106 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 7.826337e-02 | 1.106 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.826337e-02 | 1.106 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.826337e-02 | 1.106 |
| R-HSA-201556 | Signaling by ALK | 8.057827e-02 | 1.094 |
| R-HSA-5357801 | Programmed Cell Death | 8.136046e-02 | 1.090 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.760801e-02 | 1.057 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 9.685848e-02 | 1.014 |
| R-HSA-196025 | Formation of annular gap junctions | 1.060157e-01 | 0.975 |
| R-HSA-190873 | Gap junction degradation | 1.150807e-01 | 0.939 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.150807e-01 | 0.939 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.240543e-01 | 0.906 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.506238e-02 | 1.070 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 9.489659e-02 | 1.023 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 9.685848e-02 | 1.014 |
| R-HSA-8849473 | PTK6 Expression | 9.685848e-02 | 1.014 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.060157e-01 | 0.975 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.240543e-01 | 0.906 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 8.661322e-02 | 1.062 |
| R-HSA-165159 | MTOR signalling | 9.277929e-02 | 1.033 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 9.685848e-02 | 1.014 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.240543e-01 | 0.906 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.054744e-01 | 0.977 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 8.760801e-02 | 1.057 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.054744e-01 | 0.977 |
| R-HSA-72312 | rRNA processing | 1.163023e-01 | 0.934 |
| R-HSA-397014 | Muscle contraction | 8.980352e-02 | 1.047 |
| R-HSA-8948747 | Regulation of PTEN localization | 9.685848e-02 | 1.014 |
| R-HSA-157579 | Telomere Maintenance | 9.895567e-02 | 1.005 |
| R-HSA-69239 | Synthesis of DNA | 1.224729e-01 | 0.912 |
| R-HSA-162587 | HIV Life Cycle | 1.048176e-01 | 0.980 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.150807e-01 | 0.939 |
| R-HSA-73894 | DNA Repair | 9.509923e-02 | 1.022 |
| R-HSA-69242 | S Phase | 9.078036e-02 | 1.042 |
| R-HSA-373752 | Netrin-1 signaling | 9.906883e-02 | 1.004 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.150807e-01 | 0.939 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.381687e-02 | 1.028 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.191385e-01 | 0.924 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.467241e-02 | 1.072 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.284729e-01 | 0.891 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.287065e-01 | 0.890 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.417310e-01 | 0.849 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.504360e-01 | 0.823 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.675835e-01 | 0.776 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.843870e-01 | 0.734 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.843870e-01 | 0.734 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.843870e-01 | 0.734 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.926619e-01 | 0.715 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.926619e-01 | 0.715 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.169892e-01 | 0.664 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.169892e-01 | 0.664 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.169892e-01 | 0.664 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.249353e-01 | 0.648 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.249353e-01 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.249353e-01 | 0.648 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.249353e-01 | 0.648 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.249353e-01 | 0.648 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.249353e-01 | 0.648 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.328012e-01 | 0.633 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.405878e-01 | 0.619 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.405878e-01 | 0.619 |
| R-HSA-429947 | Deadenylation of mRNA | 2.634794e-01 | 0.579 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.337788e-01 | 0.874 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.337788e-01 | 0.874 |
| R-HSA-156902 | Peptide chain elongation | 2.597718e-01 | 0.585 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.074324e-01 | 0.683 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.494667e-01 | 0.825 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.329374e-01 | 0.876 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.008534e-01 | 0.697 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.417310e-01 | 0.849 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.417310e-01 | 0.849 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.504360e-01 | 0.823 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.590532e-01 | 0.798 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.590532e-01 | 0.798 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.926619e-01 | 0.715 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.089622e-01 | 0.680 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.089622e-01 | 0.680 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.634794e-01 | 0.579 |
| R-HSA-1268020 | Mitochondrial protein import | 1.600855e-01 | 0.796 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.853543e-01 | 0.732 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.000385e-01 | 0.699 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.675835e-01 | 0.776 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.760279e-01 | 0.754 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.843870e-01 | 0.734 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.482959e-01 | 0.605 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.355491e-01 | 0.868 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.447516e-01 | 0.611 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.926619e-01 | 0.715 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.328012e-01 | 0.633 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.634794e-01 | 0.579 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.238098e-01 | 0.650 |
| R-HSA-69306 | DNA Replication | 2.534097e-01 | 0.596 |
| R-HSA-2028269 | Signaling by Hippo | 2.008534e-01 | 0.697 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 2.506935e-01 | 0.601 |
| R-HSA-73886 | Chromosome Maintenance | 1.598373e-01 | 0.796 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.534097e-01 | 0.596 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.675835e-01 | 0.776 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.008534e-01 | 0.697 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.169892e-01 | 0.664 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.405878e-01 | 0.619 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.249353e-01 | 0.648 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.504360e-01 | 0.823 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.504360e-01 | 0.823 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.675835e-01 | 0.776 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.843870e-01 | 0.734 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.089622e-01 | 0.680 |
| R-HSA-162906 | HIV Infection | 2.449434e-01 | 0.611 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.405878e-01 | 0.619 |
| R-HSA-8964038 | LDL clearance | 2.482959e-01 | 0.605 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.760279e-01 | 0.754 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.249353e-01 | 0.648 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.405878e-01 | 0.619 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.504360e-01 | 0.823 |
| R-HSA-9865881 | Complex III assembly | 2.634794e-01 | 0.579 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.506935e-01 | 0.601 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.169892e-01 | 0.664 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.328012e-01 | 0.633 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.817081e-01 | 0.741 |
| R-HSA-373753 | Nephrin family interactions | 2.249353e-01 | 0.648 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.522586e-01 | 0.598 |
| R-HSA-210993 | Tie2 Signaling | 2.089622e-01 | 0.680 |
| R-HSA-186797 | Signaling by PDGF | 1.600855e-01 | 0.796 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.696087e-01 | 0.771 |
| R-HSA-177929 | Signaling by EGFR | 1.390005e-01 | 0.857 |
| R-HSA-9830369 | Kidney development | 1.780729e-01 | 0.749 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.559261e-01 | 0.592 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.708385e-01 | 0.767 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.328012e-01 | 0.633 |
| R-HSA-5218859 | Regulated Necrosis | 1.817081e-01 | 0.741 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.111403e-01 | 0.675 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 1.459600e-01 | 0.836 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.560146e-01 | 0.592 |
| R-HSA-9711097 | Cellular response to starvation | 2.670520e-01 | 0.573 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.709565e-01 | 0.567 |
| R-HSA-9620244 | Long-term potentiation | 2.709565e-01 | 0.567 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.709565e-01 | 0.567 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.710458e-01 | 0.567 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.725342e-01 | 0.565 |
| R-HSA-157118 | Signaling by NOTCH | 2.738328e-01 | 0.563 |
| R-HSA-109581 | Apoptosis | 2.780287e-01 | 0.556 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.783581e-01 | 0.555 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.783581e-01 | 0.555 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.783581e-01 | 0.555 |
| R-HSA-70635 | Urea cycle | 2.783581e-01 | 0.555 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.783581e-01 | 0.555 |
| R-HSA-525793 | Myogenesis | 2.783581e-01 | 0.555 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.783581e-01 | 0.555 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.783581e-01 | 0.555 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.785602e-01 | 0.555 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.785602e-01 | 0.555 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.823158e-01 | 0.549 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.835343e-01 | 0.547 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.856850e-01 | 0.544 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.856850e-01 | 0.544 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.856850e-01 | 0.544 |
| R-HSA-201451 | Signaling by BMP | 2.856850e-01 | 0.544 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.856850e-01 | 0.544 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.856850e-01 | 0.544 |
| R-HSA-264876 | Insulin processing | 2.856850e-01 | 0.544 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.860698e-01 | 0.544 |
| R-HSA-1474290 | Collagen formation | 2.860698e-01 | 0.544 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.898218e-01 | 0.538 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.929380e-01 | 0.533 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.929380e-01 | 0.533 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.929380e-01 | 0.533 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.929380e-01 | 0.533 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.929380e-01 | 0.533 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.935717e-01 | 0.532 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.001178e-01 | 0.523 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.001178e-01 | 0.523 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.010632e-01 | 0.521 |
| R-HSA-109582 | Hemostasis | 3.056170e-01 | 0.515 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.072251e-01 | 0.513 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.072251e-01 | 0.513 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.072251e-01 | 0.513 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.072251e-01 | 0.513 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.072251e-01 | 0.513 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.072251e-01 | 0.513 |
| R-HSA-3214847 | HATs acetylate histones | 3.085417e-01 | 0.511 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.111811e-01 | 0.507 |
| R-HSA-182971 | EGFR downregulation | 3.142607e-01 | 0.503 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.160048e-01 | 0.500 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.167253e-01 | 0.499 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.197297e-01 | 0.495 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.197297e-01 | 0.495 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.212253e-01 | 0.493 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.212253e-01 | 0.493 |
| R-HSA-69190 | DNA strand elongation | 3.212253e-01 | 0.493 |
| R-HSA-192823 | Viral mRNA Translation | 3.234499e-01 | 0.490 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.261552e-01 | 0.487 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.271650e-01 | 0.485 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.271650e-01 | 0.485 |
| R-HSA-168255 | Influenza Infection | 3.278189e-01 | 0.484 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.281195e-01 | 0.484 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.281195e-01 | 0.484 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.281195e-01 | 0.484 |
| R-HSA-9930044 | Nuclear RNA decay | 3.281195e-01 | 0.484 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.281195e-01 | 0.484 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.281195e-01 | 0.484 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.281195e-01 | 0.484 |
| R-HSA-2559583 | Cellular Senescence | 3.305925e-01 | 0.481 |
| R-HSA-390522 | Striated Muscle Contraction | 3.349442e-01 | 0.475 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.349442e-01 | 0.475 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.349442e-01 | 0.475 |
| R-HSA-449147 | Signaling by Interleukins | 3.375477e-01 | 0.472 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.416999e-01 | 0.466 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.416999e-01 | 0.466 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.416999e-01 | 0.466 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.416999e-01 | 0.466 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.419694e-01 | 0.466 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.483875e-01 | 0.458 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.483875e-01 | 0.458 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.483875e-01 | 0.458 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.493344e-01 | 0.457 |
| R-HSA-597592 | Post-translational protein modification | 3.503563e-01 | 0.455 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.550075e-01 | 0.450 |
| R-HSA-3371511 | HSF1 activation | 3.550075e-01 | 0.450 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.550075e-01 | 0.450 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.615606e-01 | 0.442 |
| R-HSA-419037 | NCAM1 interactions | 3.615606e-01 | 0.442 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.680476e-01 | 0.434 |
| R-HSA-9679506 | SARS-CoV Infections | 3.718100e-01 | 0.430 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.744691e-01 | 0.427 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.744691e-01 | 0.427 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.744691e-01 | 0.427 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.744691e-01 | 0.427 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.808257e-01 | 0.419 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.808257e-01 | 0.419 |
| R-HSA-167169 | HIV Transcription Elongation | 3.808257e-01 | 0.419 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.808257e-01 | 0.419 |
| R-HSA-3371568 | Attenuation phase | 3.808257e-01 | 0.419 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.808257e-01 | 0.419 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.808257e-01 | 0.419 |
| R-HSA-5663205 | Infectious disease | 3.819752e-01 | 0.418 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.857099e-01 | 0.414 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.871181e-01 | 0.412 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.871181e-01 | 0.412 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.871181e-01 | 0.412 |
| R-HSA-5693538 | Homology Directed Repair | 3.893012e-01 | 0.410 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.928832e-01 | 0.406 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.933470e-01 | 0.405 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.940594e-01 | 0.404 |
| R-HSA-68875 | Mitotic Prophase | 3.964559e-01 | 0.402 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.997353e-01 | 0.398 |
| R-HSA-3371556 | Cellular response to heat stress | 4.000190e-01 | 0.398 |
| R-HSA-1280218 | Adaptive Immune System | 4.042343e-01 | 0.393 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.071158e-01 | 0.390 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.116585e-01 | 0.385 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.176394e-01 | 0.379 |
| R-HSA-774815 | Nucleosome assembly | 4.176394e-01 | 0.379 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 4.176394e-01 | 0.379 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.176394e-01 | 0.379 |
| R-HSA-69206 | G1/S Transition | 4.176850e-01 | 0.379 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.235599e-01 | 0.373 |
| R-HSA-9675135 | Diseases of DNA repair | 4.235599e-01 | 0.373 |
| R-HSA-69481 | G2/M Checkpoints | 4.246787e-01 | 0.372 |
| R-HSA-392499 | Metabolism of proteins | 4.251781e-01 | 0.371 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.294205e-01 | 0.367 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.294205e-01 | 0.367 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.352220e-01 | 0.361 |
| R-HSA-5576891 | Cardiac conduction | 4.419710e-01 | 0.355 |
| R-HSA-8951664 | Neddylation | 4.453359e-01 | 0.351 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.453955e-01 | 0.351 |
| R-HSA-9748787 | Azathioprine ADME | 4.466495e-01 | 0.350 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.522768e-01 | 0.345 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.522768e-01 | 0.345 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.522768e-01 | 0.345 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.578473e-01 | 0.339 |
| R-HSA-72187 | mRNA 3'-end processing | 4.578473e-01 | 0.339 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.578473e-01 | 0.339 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.578473e-01 | 0.339 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.630580e-01 | 0.334 |
| R-HSA-1221632 | Meiotic synapsis | 4.633614e-01 | 0.334 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.633614e-01 | 0.334 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.633614e-01 | 0.334 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.633614e-01 | 0.334 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.633614e-01 | 0.334 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.633614e-01 | 0.334 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.633614e-01 | 0.334 |
| R-HSA-74160 | Gene expression (Transcription) | 4.661024e-01 | 0.332 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.681271e-01 | 0.330 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.688197e-01 | 0.329 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.688197e-01 | 0.329 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.690355e-01 | 0.329 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.742229e-01 | 0.324 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.795715e-01 | 0.319 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.795715e-01 | 0.319 |
| R-HSA-75893 | TNF signaling | 4.795715e-01 | 0.319 |
| R-HSA-1474244 | Extracellular matrix organization | 4.807555e-01 | 0.318 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.848659e-01 | 0.314 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.888180e-01 | 0.311 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.901069e-01 | 0.310 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.901069e-01 | 0.310 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.985366e-01 | 0.302 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.004303e-01 | 0.301 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.004303e-01 | 0.301 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.047150e-01 | 0.297 |
| R-HSA-166520 | Signaling by NTRKs | 5.049503e-01 | 0.297 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.055138e-01 | 0.296 |
| R-HSA-1442490 | Collagen degradation | 5.055138e-01 | 0.296 |
| R-HSA-8953854 | Metabolism of RNA | 5.092955e-01 | 0.293 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.105459e-01 | 0.292 |
| R-HSA-9707616 | Heme signaling | 5.105459e-01 | 0.292 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.105459e-01 | 0.292 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.105459e-01 | 0.292 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.144715e-01 | 0.289 |
| R-HSA-6799198 | Complex I biogenesis | 5.155271e-01 | 0.288 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.155271e-01 | 0.288 |
| R-HSA-8848021 | Signaling by PTK6 | 5.155271e-01 | 0.288 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.155271e-01 | 0.288 |
| R-HSA-373755 | Semaphorin interactions | 5.155271e-01 | 0.288 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.176185e-01 | 0.286 |
| R-HSA-9609507 | Protein localization | 5.207521e-01 | 0.283 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.253389e-01 | 0.280 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.269786e-01 | 0.278 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.301705e-01 | 0.276 |
| R-HSA-5688426 | Deubiquitination | 5.323622e-01 | 0.274 |
| R-HSA-9610379 | HCMV Late Events | 5.331508e-01 | 0.273 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.349532e-01 | 0.272 |
| R-HSA-6798695 | Neutrophil degranulation | 5.384327e-01 | 0.269 |
| R-HSA-167172 | Transcription of the HIV genome | 5.396875e-01 | 0.268 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.532079e-01 | 0.257 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.536048e-01 | 0.257 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.536048e-01 | 0.257 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.536048e-01 | 0.257 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.581503e-01 | 0.253 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.581503e-01 | 0.253 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.581503e-01 | 0.253 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.671039e-01 | 0.246 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.671039e-01 | 0.246 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.671039e-01 | 0.246 |
| R-HSA-168256 | Immune System | 5.686829e-01 | 0.245 |
| R-HSA-8852135 | Protein ubiquitination | 5.715128e-01 | 0.243 |
| R-HSA-5689603 | UCH proteinases | 5.758770e-01 | 0.240 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.842481e-01 | 0.233 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.844735e-01 | 0.233 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.844735e-01 | 0.233 |
| R-HSA-4086400 | PCP/CE pathway | 5.844735e-01 | 0.233 |
| R-HSA-216083 | Integrin cell surface interactions | 5.844735e-01 | 0.233 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.970445e-01 | 0.224 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.011502e-01 | 0.221 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.011502e-01 | 0.221 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.052144e-01 | 0.218 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.110244e-01 | 0.214 |
| R-HSA-1500620 | Meiosis | 6.132197e-01 | 0.212 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.132197e-01 | 0.212 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.171616e-01 | 0.210 |
| R-HSA-375276 | Peptide ligand-binding receptors | 6.190435e-01 | 0.208 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.210636e-01 | 0.207 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.210636e-01 | 0.207 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.210636e-01 | 0.207 |
| R-HSA-195721 | Signaling by WNT | 6.306457e-01 | 0.200 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.362802e-01 | 0.196 |
| R-HSA-73884 | Base Excision Repair | 6.362802e-01 | 0.196 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.399323e-01 | 0.194 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.436592e-01 | 0.191 |
| R-HSA-212436 | Generic Transcription Pathway | 6.440783e-01 | 0.191 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.472927e-01 | 0.189 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.614621e-01 | 0.179 |
| R-HSA-1296071 | Potassium Channels | 6.649151e-01 | 0.177 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.717165e-01 | 0.173 |
| R-HSA-422356 | Regulation of insulin secretion | 6.717165e-01 | 0.173 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.750656e-01 | 0.171 |
| R-HSA-72766 | Translation | 6.751942e-01 | 0.171 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.849104e-01 | 0.164 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.006640e-01 | 0.154 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.037194e-01 | 0.153 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.037194e-01 | 0.153 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.067439e-01 | 0.151 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.242179e-01 | 0.140 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.242570e-01 | 0.140 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.242570e-01 | 0.140 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.270730e-01 | 0.138 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.276148e-01 | 0.138 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.298605e-01 | 0.137 |
| R-HSA-15869 | Metabolism of nucleotides | 7.364779e-01 | 0.133 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.380542e-01 | 0.132 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.380542e-01 | 0.132 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.485962e-01 | 0.126 |
| R-HSA-114608 | Platelet degranulation | 7.660398e-01 | 0.116 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.684315e-01 | 0.114 |
| R-HSA-1474165 | Reproduction | 7.754618e-01 | 0.110 |
| R-HSA-9909396 | Circadian clock | 7.800305e-01 | 0.108 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.822800e-01 | 0.107 |
| R-HSA-416476 | G alpha (q) signalling events | 7.868835e-01 | 0.104 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.910518e-01 | 0.102 |
| R-HSA-163685 | Integration of energy metabolism | 7.910518e-01 | 0.102 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.910518e-01 | 0.102 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.933529e-01 | 0.101 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.973993e-01 | 0.098 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.102624e-01 | 0.091 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.146565e-01 | 0.089 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.209291e-01 | 0.086 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.281521e-01 | 0.082 |
| R-HSA-73887 | Death Receptor Signaling | 8.281521e-01 | 0.082 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.384473e-01 | 0.077 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.586980e-01 | 0.066 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.601469e-01 | 0.065 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.601469e-01 | 0.065 |
| R-HSA-611105 | Respiratory electron transport | 8.671730e-01 | 0.062 |
| R-HSA-1643685 | Disease | 8.741502e-01 | 0.058 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.844422e-01 | 0.053 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.873827e-01 | 0.052 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.934988e-01 | 0.049 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.941463e-01 | 0.049 |
| R-HSA-428157 | Sphingolipid metabolism | 8.952336e-01 | 0.048 |
| R-HSA-72172 | mRNA Splicing | 8.994731e-01 | 0.046 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.083986e-01 | 0.042 |
| R-HSA-9748784 | Drug ADME | 9.130122e-01 | 0.040 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.190912e-01 | 0.037 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.199181e-01 | 0.036 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.215577e-01 | 0.035 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.262476e-01 | 0.033 |
| R-HSA-8939211 | ESR-mediated signaling | 9.285325e-01 | 0.032 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.285325e-01 | 0.032 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.412975e-01 | 0.026 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.512912e-01 | 0.022 |
| R-HSA-9658195 | Leishmania infection | 9.547036e-01 | 0.020 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.547036e-01 | 0.020 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.583135e-01 | 0.018 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.612366e-01 | 0.017 |
| R-HSA-1500931 | Cell-Cell communication | 9.685129e-01 | 0.014 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.807024e-01 | 0.008 |
| R-HSA-500792 | GPCR ligand binding | 9.867541e-01 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 9.879406e-01 | 0.005 |
| R-HSA-388396 | GPCR downstream signalling | 9.976427e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.984228e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.989380e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999734e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.861 | 0.608 | -2 | 0.891 |
PAK6 |
0.853 | 0.597 | -2 | 0.877 |
AURB |
0.852 | 0.610 | -2 | 0.893 |
PKACB |
0.849 | 0.515 | -2 | 0.875 |
PKG2 |
0.845 | 0.507 | -2 | 0.840 |
AURA |
0.844 | 0.595 | -2 | 0.906 |
RSK2 |
0.844 | 0.306 | -3 | 0.748 |
PKACG |
0.844 | 0.431 | -2 | 0.821 |
MNK2 |
0.843 | 0.478 | -2 | 0.870 |
PRKD2 |
0.842 | 0.239 | -3 | 0.754 |
CLK3 |
0.842 | 0.274 | 1 | 0.737 |
SKMLCK |
0.842 | 0.445 | -2 | 0.835 |
PRKD1 |
0.841 | 0.206 | -3 | 0.797 |
PAK1 |
0.841 | 0.495 | -2 | 0.872 |
PAK3 |
0.840 | 0.490 | -2 | 0.859 |
RSK3 |
0.839 | 0.290 | -3 | 0.743 |
CLK4 |
0.838 | 0.390 | -3 | 0.739 |
PKACA |
0.838 | 0.481 | -2 | 0.864 |
PIM3 |
0.838 | 0.181 | -3 | 0.805 |
CAMLCK |
0.838 | 0.491 | -2 | 0.838 |
NDR2 |
0.838 | 0.166 | -3 | 0.811 |
PRKX |
0.838 | 0.424 | -3 | 0.665 |
COT |
0.837 | 0.054 | 2 | 0.821 |
NDR1 |
0.837 | 0.249 | -3 | 0.804 |
P70S6KB |
0.836 | 0.301 | -3 | 0.768 |
CAMK1B |
0.836 | 0.256 | -3 | 0.835 |
P90RSK |
0.836 | 0.226 | -3 | 0.746 |
HIPK4 |
0.835 | 0.164 | 1 | 0.776 |
PAK4 |
0.835 | 0.572 | -2 | 0.880 |
MSK1 |
0.835 | 0.418 | -3 | 0.715 |
CLK1 |
0.833 | 0.313 | -3 | 0.727 |
PAK5 |
0.833 | 0.553 | -2 | 0.850 |
SRPK1 |
0.832 | 0.155 | -3 | 0.721 |
MNK1 |
0.832 | 0.408 | -2 | 0.852 |
WNK1 |
0.832 | 0.215 | -2 | 0.753 |
PIM1 |
0.831 | 0.195 | -3 | 0.751 |
ATR |
0.831 | 0.215 | 1 | 0.838 |
PKCD |
0.831 | 0.268 | 2 | 0.727 |
CLK2 |
0.831 | 0.340 | -3 | 0.726 |
MSK2 |
0.831 | 0.321 | -3 | 0.704 |
DAPK2 |
0.831 | 0.408 | -3 | 0.837 |
PAK2 |
0.831 | 0.486 | -2 | 0.861 |
MYLK4 |
0.830 | 0.434 | -2 | 0.883 |
MST4 |
0.829 | 0.172 | 2 | 0.806 |
RSK4 |
0.828 | 0.304 | -3 | 0.714 |
AKT2 |
0.828 | 0.322 | -3 | 0.666 |
NLK |
0.828 | 0.094 | 1 | 0.757 |
CDC7 |
0.827 | 0.009 | 1 | 0.743 |
PRKD3 |
0.827 | 0.188 | -3 | 0.724 |
AMPKA1 |
0.827 | 0.169 | -3 | 0.829 |
PRPK |
0.826 | -0.080 | -1 | 0.879 |
TSSK1 |
0.826 | 0.188 | -3 | 0.850 |
MAPKAPK3 |
0.826 | 0.119 | -3 | 0.751 |
MARK4 |
0.825 | 0.084 | 4 | 0.902 |
RAF1 |
0.825 | 0.026 | 1 | 0.772 |
PKN2 |
0.825 | 0.193 | -3 | 0.809 |
SRPK2 |
0.824 | 0.132 | -3 | 0.640 |
AKT1 |
0.824 | 0.392 | -3 | 0.686 |
NIK |
0.824 | 0.211 | -3 | 0.851 |
PKN3 |
0.824 | 0.111 | -3 | 0.796 |
RIPK3 |
0.824 | 0.142 | 3 | 0.771 |
SGK3 |
0.824 | 0.324 | -3 | 0.740 |
LATS2 |
0.824 | 0.081 | -5 | 0.759 |
TBK1 |
0.824 | -0.028 | 1 | 0.691 |
MOS |
0.824 | 0.006 | 1 | 0.773 |
CAMK2D |
0.823 | 0.068 | -3 | 0.813 |
ICK |
0.823 | 0.137 | -3 | 0.803 |
TSSK2 |
0.823 | 0.155 | -5 | 0.827 |
DYRK2 |
0.823 | 0.146 | 1 | 0.685 |
CDKL1 |
0.823 | 0.045 | -3 | 0.766 |
PDHK1 |
0.823 | -0.030 | 1 | 0.796 |
ULK2 |
0.822 | -0.070 | 2 | 0.745 |
DYRK3 |
0.822 | 0.330 | 1 | 0.719 |
PDHK4 |
0.822 | -0.116 | 1 | 0.788 |
GCN2 |
0.822 | -0.107 | 2 | 0.759 |
AMPKA2 |
0.822 | 0.153 | -3 | 0.798 |
CHAK2 |
0.822 | 0.041 | -1 | 0.861 |
WNK3 |
0.821 | 0.088 | 1 | 0.767 |
MELK |
0.821 | 0.145 | -3 | 0.783 |
NUAK2 |
0.820 | 0.057 | -3 | 0.816 |
CAMK4 |
0.820 | 0.235 | -3 | 0.795 |
MAPKAPK2 |
0.820 | 0.092 | -3 | 0.706 |
TGFBR2 |
0.820 | -0.003 | -2 | 0.592 |
IKKB |
0.820 | -0.110 | -2 | 0.573 |
BMPR2 |
0.820 | -0.100 | -2 | 0.667 |
IKKE |
0.820 | -0.038 | 1 | 0.695 |
HIPK1 |
0.820 | 0.200 | 1 | 0.695 |
NIM1 |
0.820 | 0.073 | 3 | 0.786 |
MTOR |
0.819 | -0.090 | 1 | 0.719 |
PKCA |
0.819 | 0.224 | 2 | 0.669 |
PIM2 |
0.819 | 0.221 | -3 | 0.722 |
CDKL5 |
0.819 | 0.033 | -3 | 0.761 |
QSK |
0.819 | 0.128 | 4 | 0.872 |
BCKDK |
0.818 | -0.019 | -1 | 0.840 |
HIPK2 |
0.818 | 0.164 | 1 | 0.599 |
ATM |
0.818 | 0.142 | 1 | 0.808 |
DSTYK |
0.818 | -0.084 | 2 | 0.830 |
CAMK2G |
0.817 | -0.063 | 2 | 0.784 |
ERK5 |
0.817 | -0.020 | 1 | 0.696 |
DNAPK |
0.816 | 0.197 | 1 | 0.783 |
NEK6 |
0.816 | -0.036 | -2 | 0.635 |
RIPK1 |
0.816 | 0.078 | 1 | 0.772 |
HUNK |
0.815 | -0.007 | 2 | 0.762 |
SMMLCK |
0.815 | 0.385 | -3 | 0.788 |
SIK |
0.815 | 0.101 | -3 | 0.735 |
PKCB |
0.814 | 0.143 | 2 | 0.678 |
PKCZ |
0.814 | 0.199 | 2 | 0.730 |
PKCG |
0.814 | 0.170 | 2 | 0.682 |
DAPK3 |
0.814 | 0.444 | -3 | 0.773 |
SRPK3 |
0.814 | 0.100 | -3 | 0.684 |
PKG1 |
0.813 | 0.424 | -2 | 0.819 |
AKT3 |
0.813 | 0.335 | -3 | 0.601 |
PKR |
0.813 | 0.148 | 1 | 0.802 |
HIPK3 |
0.813 | 0.182 | 1 | 0.685 |
QIK |
0.813 | 0.065 | -3 | 0.808 |
CAMK2B |
0.812 | 0.066 | 2 | 0.767 |
KIS |
0.812 | 0.021 | 1 | 0.637 |
P70S6K |
0.812 | 0.205 | -3 | 0.677 |
IRE1 |
0.812 | 0.051 | 1 | 0.767 |
IRE2 |
0.812 | 0.098 | 2 | 0.695 |
CAMK1G |
0.812 | 0.165 | -3 | 0.729 |
MRCKB |
0.812 | 0.406 | -3 | 0.717 |
NEK7 |
0.811 | -0.119 | -3 | 0.786 |
GRK1 |
0.811 | 0.006 | -2 | 0.575 |
PKCH |
0.811 | 0.181 | 2 | 0.664 |
SMG1 |
0.811 | 0.126 | 1 | 0.829 |
LATS1 |
0.811 | 0.126 | -3 | 0.820 |
IKKA |
0.810 | -0.064 | -2 | 0.533 |
NEK9 |
0.810 | -0.055 | 2 | 0.794 |
SSTK |
0.810 | 0.174 | 4 | 0.867 |
NEK2 |
0.810 | 0.106 | 2 | 0.767 |
NUAK1 |
0.810 | 0.026 | -3 | 0.766 |
PKCT |
0.810 | 0.246 | 2 | 0.679 |
ULK1 |
0.810 | -0.137 | -3 | 0.768 |
CAMK2A |
0.810 | 0.073 | 2 | 0.755 |
CDK7 |
0.810 | 0.038 | 1 | 0.607 |
MLK1 |
0.809 | -0.083 | 2 | 0.755 |
PHKG1 |
0.809 | 0.054 | -3 | 0.798 |
GRK5 |
0.809 | -0.112 | -3 | 0.824 |
MRCKA |
0.808 | 0.390 | -3 | 0.729 |
CAMK1D |
0.808 | 0.198 | -3 | 0.669 |
CHAK1 |
0.808 | 0.031 | 2 | 0.743 |
MLK2 |
0.807 | -0.047 | 2 | 0.775 |
DYRK1A |
0.807 | 0.115 | 1 | 0.681 |
CDK13 |
0.807 | 0.052 | 1 | 0.587 |
MARK3 |
0.807 | 0.066 | 4 | 0.851 |
CDK8 |
0.807 | -0.009 | 1 | 0.609 |
ROCK2 |
0.807 | 0.406 | -3 | 0.764 |
DYRK4 |
0.806 | 0.130 | 1 | 0.595 |
SGK1 |
0.806 | 0.278 | -3 | 0.584 |
DYRK1B |
0.806 | 0.145 | 1 | 0.606 |
ANKRD3 |
0.806 | -0.061 | 1 | 0.788 |
SNRK |
0.805 | 0.053 | 2 | 0.648 |
VRK2 |
0.805 | 0.065 | 1 | 0.819 |
MARK2 |
0.805 | 0.054 | 4 | 0.821 |
MASTL |
0.805 | -0.187 | -2 | 0.625 |
CDK5 |
0.805 | 0.061 | 1 | 0.617 |
BRSK1 |
0.805 | 0.043 | -3 | 0.766 |
CDK19 |
0.804 | 0.002 | 1 | 0.575 |
PKCI |
0.804 | 0.242 | 2 | 0.690 |
PHKG2 |
0.804 | 0.130 | -3 | 0.785 |
DCAMKL1 |
0.804 | 0.109 | -3 | 0.767 |
FAM20C |
0.804 | 0.036 | 2 | 0.617 |
MAPKAPK5 |
0.803 | 0.006 | -3 | 0.673 |
CDK12 |
0.803 | 0.068 | 1 | 0.565 |
DAPK1 |
0.803 | 0.392 | -3 | 0.754 |
BRSK2 |
0.803 | 0.019 | -3 | 0.793 |
CAMK1A |
0.802 | 0.221 | -3 | 0.636 |
GRK6 |
0.802 | -0.071 | 1 | 0.726 |
DLK |
0.802 | -0.145 | 1 | 0.748 |
DMPK1 |
0.802 | 0.438 | -3 | 0.741 |
TTBK2 |
0.802 | -0.118 | 2 | 0.714 |
WNK4 |
0.801 | 0.097 | -2 | 0.715 |
ROCK1 |
0.801 | 0.423 | -3 | 0.729 |
MARK1 |
0.801 | 0.040 | 4 | 0.872 |
CHK1 |
0.801 | 0.009 | -3 | 0.810 |
CDK18 |
0.800 | 0.044 | 1 | 0.542 |
MLK3 |
0.800 | -0.048 | 2 | 0.690 |
CDK9 |
0.800 | 0.034 | 1 | 0.597 |
PKCE |
0.800 | 0.240 | 2 | 0.664 |
ALK4 |
0.800 | -0.064 | -2 | 0.614 |
TLK2 |
0.799 | -0.014 | 1 | 0.781 |
BUB1 |
0.799 | 0.242 | -5 | 0.802 |
TGFBR1 |
0.799 | -0.050 | -2 | 0.585 |
IRAK4 |
0.799 | 0.074 | 1 | 0.781 |
PRP4 |
0.798 | 0.066 | -3 | 0.765 |
GRK4 |
0.798 | -0.143 | -2 | 0.594 |
P38A |
0.798 | 0.022 | 1 | 0.624 |
BMPR1B |
0.798 | -0.026 | 1 | 0.655 |
JNK2 |
0.797 | 0.031 | 1 | 0.560 |
CDK14 |
0.796 | 0.101 | 1 | 0.584 |
YSK4 |
0.796 | -0.107 | 1 | 0.715 |
CDK10 |
0.796 | 0.125 | 1 | 0.570 |
DCAMKL2 |
0.795 | 0.050 | -3 | 0.793 |
MEKK1 |
0.795 | -0.013 | 1 | 0.766 |
MEK1 |
0.795 | -0.130 | 2 | 0.781 |
CDK1 |
0.795 | 0.017 | 1 | 0.560 |
PLK1 |
0.795 | -0.131 | -2 | 0.599 |
MPSK1 |
0.794 | 0.066 | 1 | 0.706 |
CDK17 |
0.793 | 0.024 | 1 | 0.489 |
PERK |
0.793 | -0.072 | -2 | 0.592 |
MST3 |
0.793 | 0.073 | 2 | 0.776 |
ERK1 |
0.793 | 0.006 | 1 | 0.558 |
P38B |
0.793 | 0.014 | 1 | 0.564 |
ALK2 |
0.792 | -0.055 | -2 | 0.587 |
HRI |
0.792 | -0.093 | -2 | 0.623 |
NEK5 |
0.792 | 0.011 | 1 | 0.775 |
MLK4 |
0.792 | -0.085 | 2 | 0.673 |
MAK |
0.791 | 0.124 | -2 | 0.632 |
ERK2 |
0.791 | -0.005 | 1 | 0.608 |
CRIK |
0.791 | 0.282 | -3 | 0.681 |
JNK3 |
0.791 | -0.000 | 1 | 0.589 |
PKN1 |
0.791 | 0.123 | -3 | 0.700 |
P38G |
0.791 | 0.021 | 1 | 0.489 |
CDK2 |
0.791 | -0.015 | 1 | 0.627 |
BRAF |
0.791 | -0.061 | -4 | 0.774 |
PLK3 |
0.790 | -0.099 | 2 | 0.735 |
ACVR2A |
0.790 | -0.091 | -2 | 0.569 |
CHK2 |
0.790 | 0.117 | -3 | 0.617 |
MOK |
0.789 | 0.127 | 1 | 0.717 |
PINK1 |
0.789 | -0.084 | 1 | 0.756 |
TLK1 |
0.789 | -0.071 | -2 | 0.601 |
ACVR2B |
0.789 | -0.090 | -2 | 0.570 |
PLK4 |
0.788 | -0.101 | 2 | 0.617 |
MEK5 |
0.788 | -0.102 | 2 | 0.771 |
CDK3 |
0.788 | 0.044 | 1 | 0.506 |
LKB1 |
0.787 | 0.067 | -3 | 0.798 |
GRK7 |
0.787 | -0.062 | 1 | 0.649 |
TAO3 |
0.786 | 0.003 | 1 | 0.726 |
LOK |
0.786 | 0.139 | -2 | 0.661 |
ZAK |
0.786 | -0.108 | 1 | 0.730 |
CAMKK1 |
0.786 | -0.052 | -2 | 0.596 |
P38D |
0.785 | 0.022 | 1 | 0.538 |
MEKK2 |
0.785 | -0.085 | 2 | 0.760 |
TAO2 |
0.785 | 0.020 | 2 | 0.792 |
NEK4 |
0.784 | 0.034 | 1 | 0.764 |
TNIK |
0.784 | 0.119 | 3 | 0.900 |
GSK3B |
0.783 | 0.032 | 4 | 0.490 |
CAMKK2 |
0.783 | -0.017 | -2 | 0.610 |
DRAK1 |
0.783 | -0.074 | 1 | 0.620 |
CDK16 |
0.783 | 0.020 | 1 | 0.508 |
HGK |
0.782 | 0.064 | 3 | 0.900 |
CDK4 |
0.782 | 0.062 | 1 | 0.559 |
KHS1 |
0.781 | 0.154 | 1 | 0.745 |
GRK2 |
0.781 | -0.119 | -2 | 0.529 |
SBK |
0.781 | 0.088 | -3 | 0.552 |
BMPR1A |
0.781 | -0.047 | 1 | 0.641 |
MEKK6 |
0.780 | 0.032 | 1 | 0.737 |
NEK8 |
0.780 | -0.040 | 2 | 0.762 |
IRAK1 |
0.780 | -0.123 | -1 | 0.785 |
VRK1 |
0.779 | 0.042 | 2 | 0.793 |
MINK |
0.779 | 0.047 | 1 | 0.743 |
PASK |
0.779 | -0.033 | -3 | 0.818 |
PDK1 |
0.779 | -0.015 | 1 | 0.712 |
NEK1 |
0.779 | 0.075 | 1 | 0.757 |
MEKK3 |
0.779 | -0.188 | 1 | 0.734 |
HPK1 |
0.779 | 0.100 | 1 | 0.725 |
GSK3A |
0.779 | 0.032 | 4 | 0.500 |
GCK |
0.778 | 0.041 | 1 | 0.721 |
KHS2 |
0.778 | 0.152 | 1 | 0.746 |
ERK7 |
0.778 | -0.007 | 2 | 0.494 |
GAK |
0.778 | -0.009 | 1 | 0.727 |
LRRK2 |
0.778 | -0.006 | 2 | 0.796 |
STK33 |
0.777 | -0.016 | 2 | 0.601 |
PDHK3_TYR |
0.777 | 0.103 | 4 | 0.922 |
TTBK1 |
0.777 | -0.122 | 2 | 0.633 |
CK1E |
0.777 | -0.059 | -3 | 0.520 |
CDK6 |
0.777 | 0.037 | 1 | 0.568 |
EEF2K |
0.777 | 0.015 | 3 | 0.855 |
LIMK2_TYR |
0.776 | 0.207 | -3 | 0.864 |
MAP3K15 |
0.775 | -0.038 | 1 | 0.712 |
SLK |
0.775 | 0.020 | -2 | 0.579 |
CK1G1 |
0.774 | -0.053 | -3 | 0.507 |
TESK1_TYR |
0.774 | 0.084 | 3 | 0.881 |
NEK11 |
0.774 | -0.136 | 1 | 0.714 |
YSK1 |
0.772 | 0.030 | 2 | 0.764 |
MST2 |
0.772 | -0.087 | 1 | 0.741 |
CK1A2 |
0.772 | -0.010 | -3 | 0.468 |
PBK |
0.771 | 0.026 | 1 | 0.655 |
TAK1 |
0.770 | -0.056 | 1 | 0.743 |
CK1D |
0.770 | -0.051 | -3 | 0.470 |
PKMYT1_TYR |
0.770 | 0.017 | 3 | 0.849 |
MYO3B |
0.770 | 0.144 | 2 | 0.774 |
HASPIN |
0.769 | 0.070 | -1 | 0.716 |
RET |
0.769 | 0.122 | 1 | 0.760 |
NEK3 |
0.769 | -0.027 | 1 | 0.726 |
EPHA6 |
0.769 | 0.105 | -1 | 0.887 |
MST1 |
0.768 | -0.066 | 1 | 0.737 |
RIPK2 |
0.767 | -0.110 | 1 | 0.684 |
MAP2K7_TYR |
0.767 | -0.044 | 2 | 0.811 |
PDHK4_TYR |
0.767 | 0.003 | 2 | 0.814 |
JNK1 |
0.766 | -0.032 | 1 | 0.538 |
MEK2 |
0.766 | -0.118 | 2 | 0.772 |
GRK3 |
0.766 | -0.115 | -2 | 0.493 |
MST1R |
0.765 | 0.047 | 3 | 0.832 |
PINK1_TYR |
0.764 | -0.038 | 1 | 0.751 |
MAP2K4_TYR |
0.764 | -0.105 | -1 | 0.897 |
TYK2 |
0.764 | 0.014 | 1 | 0.758 |
EPHB4 |
0.763 | 0.044 | -1 | 0.883 |
DDR1 |
0.762 | 0.049 | 4 | 0.862 |
LIMK1_TYR |
0.762 | -0.019 | 2 | 0.809 |
TTK |
0.762 | -0.001 | -2 | 0.609 |
ROS1 |
0.762 | 0.016 | 3 | 0.797 |
MAP2K6_TYR |
0.761 | -0.124 | -1 | 0.895 |
BMPR2_TYR |
0.761 | -0.053 | -1 | 0.885 |
TNNI3K_TYR |
0.761 | 0.113 | 1 | 0.787 |
TYRO3 |
0.761 | -0.012 | 3 | 0.823 |
ABL2 |
0.761 | 0.058 | -1 | 0.854 |
PLK2 |
0.761 | -0.063 | -3 | 0.776 |
JAK2 |
0.761 | -0.010 | 1 | 0.754 |
CK2A2 |
0.760 | -0.058 | 1 | 0.583 |
TNK1 |
0.760 | 0.114 | 3 | 0.803 |
OSR1 |
0.759 | -0.031 | 2 | 0.747 |
BIKE |
0.758 | 0.008 | 1 | 0.615 |
MYO3A |
0.758 | 0.037 | 1 | 0.770 |
CSF1R |
0.758 | -0.029 | 3 | 0.823 |
TAO1 |
0.758 | -0.001 | 1 | 0.687 |
TNK2 |
0.757 | 0.039 | 3 | 0.770 |
ABL1 |
0.757 | 0.034 | -1 | 0.848 |
PDHK1_TYR |
0.755 | -0.192 | -1 | 0.903 |
JAK3 |
0.755 | -0.029 | 1 | 0.723 |
PDGFRB |
0.755 | -0.016 | 3 | 0.826 |
YANK3 |
0.753 | -0.005 | 2 | 0.416 |
KDR |
0.752 | 0.029 | 3 | 0.789 |
DDR2 |
0.752 | 0.129 | 3 | 0.746 |
JAK1 |
0.752 | 0.017 | 1 | 0.709 |
ASK1 |
0.752 | -0.090 | 1 | 0.701 |
NEK10_TYR |
0.752 | -0.011 | 1 | 0.639 |
AXL |
0.751 | 0.004 | 3 | 0.797 |
FGFR2 |
0.751 | -0.048 | 3 | 0.804 |
CK2A1 |
0.751 | -0.067 | 1 | 0.564 |
WEE1_TYR |
0.749 | 0.038 | -1 | 0.796 |
TXK |
0.749 | -0.016 | 1 | 0.699 |
EPHB3 |
0.749 | -0.028 | -1 | 0.871 |
YES1 |
0.749 | -0.051 | -1 | 0.870 |
FLT3 |
0.748 | -0.069 | 3 | 0.824 |
INSRR |
0.748 | -0.076 | 3 | 0.767 |
EPHA4 |
0.748 | -0.059 | 2 | 0.725 |
PDGFRA |
0.748 | -0.073 | 3 | 0.825 |
EPHA1 |
0.748 | 0.040 | 3 | 0.795 |
FGFR1 |
0.747 | -0.078 | 3 | 0.776 |
FER |
0.747 | -0.117 | 1 | 0.753 |
EPHB1 |
0.747 | -0.062 | 1 | 0.740 |
TEK |
0.747 | -0.075 | 3 | 0.749 |
MERTK |
0.747 | -0.008 | 3 | 0.794 |
EPHB2 |
0.746 | -0.044 | -1 | 0.864 |
KIT |
0.746 | -0.090 | 3 | 0.815 |
LTK |
0.746 | -0.018 | 3 | 0.745 |
FGR |
0.746 | -0.127 | 1 | 0.723 |
HCK |
0.746 | -0.080 | -1 | 0.856 |
ITK |
0.746 | -0.074 | -1 | 0.844 |
ALK |
0.745 | -0.044 | 3 | 0.729 |
AAK1 |
0.745 | 0.032 | 1 | 0.517 |
LCK |
0.745 | -0.032 | -1 | 0.851 |
SRMS |
0.744 | -0.117 | 1 | 0.734 |
BLK |
0.743 | -0.009 | -1 | 0.857 |
TEC |
0.742 | -0.035 | -1 | 0.810 |
EPHA7 |
0.742 | -0.025 | 2 | 0.728 |
MET |
0.742 | -0.075 | 3 | 0.808 |
BMX |
0.741 | -0.038 | -1 | 0.783 |
BTK |
0.739 | -0.125 | -1 | 0.823 |
EPHA3 |
0.739 | -0.083 | 2 | 0.710 |
STLK3 |
0.739 | -0.136 | 1 | 0.706 |
PTK6 |
0.738 | -0.142 | -1 | 0.780 |
NTRK1 |
0.737 | -0.139 | -1 | 0.860 |
ALPHAK3 |
0.737 | -0.121 | -1 | 0.802 |
FGFR3 |
0.736 | -0.103 | 3 | 0.779 |
FRK |
0.736 | -0.080 | -1 | 0.875 |
FLT4 |
0.735 | -0.104 | 3 | 0.764 |
INSR |
0.735 | -0.120 | 3 | 0.746 |
NTRK2 |
0.735 | -0.140 | 3 | 0.770 |
PTK2B |
0.733 | -0.061 | -1 | 0.824 |
EPHA5 |
0.733 | -0.058 | 2 | 0.712 |
ERBB2 |
0.731 | -0.160 | 1 | 0.681 |
FLT1 |
0.731 | -0.125 | -1 | 0.854 |
FYN |
0.730 | -0.084 | -1 | 0.828 |
MATK |
0.730 | -0.093 | -1 | 0.783 |
LYN |
0.729 | -0.118 | 3 | 0.727 |
NTRK3 |
0.728 | -0.135 | -1 | 0.814 |
CK1A |
0.728 | -0.091 | -3 | 0.377 |
EPHA8 |
0.727 | -0.094 | -1 | 0.848 |
CSK |
0.723 | -0.141 | 2 | 0.735 |
MUSK |
0.722 | -0.109 | 1 | 0.572 |
EGFR |
0.722 | -0.124 | 1 | 0.591 |
FGFR4 |
0.719 | -0.128 | -1 | 0.808 |
SRC |
0.719 | -0.137 | -1 | 0.831 |
EPHA2 |
0.718 | -0.094 | -1 | 0.815 |
PTK2 |
0.716 | -0.076 | -1 | 0.799 |
IGF1R |
0.715 | -0.145 | 3 | 0.675 |
CK1G3 |
0.715 | -0.062 | -3 | 0.331 |
SYK |
0.711 | -0.118 | -1 | 0.792 |
ERBB4 |
0.709 | -0.120 | 1 | 0.600 |
YANK2 |
0.709 | -0.085 | 2 | 0.423 |
FES |
0.701 | -0.157 | -1 | 0.760 |
ZAP70 |
0.692 | -0.100 | -1 | 0.722 |
CK1G2 |
0.686 | -0.114 | -3 | 0.425 |