Motif 606 (n=117)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14513 | NCKAP5 | S128 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14686 | KMT2D | S4814 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15083 | ERC2 | S187 | ochoa | ERC protein 2 | Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. |
| O43493 | TGOLN2 | S66 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O60306 | AQR | S956 | ochoa | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| O60669 | SLC16A7 | S457 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O60828 | PQBP1 | S94 | ochoa | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| O75369 | FLNB | S2325 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75534 | CSDE1 | S584 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O75694 | NUP155 | S1133 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O75976 | CPD | S1361 | ochoa | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| O94916 | NFAT5 | S266 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94986 | CEP152 | S1614 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95292 | VAPB | S159 | ochoa | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| P05455 | SSB | S92 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P07919 | UQCRH | S58 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P08240 | SRPRA | S142 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P17677 | GAP43 | S151 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P17980 | PSMC3 | S376 | ochoa | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P20700 | LMNB1 | S279 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P21127 | CDK11B | S229 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P21333 | FLNA | S2370 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25054 | APC | S2054 | psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P30622 | CLIP1 | S1271 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31415 | CASQ1 | S191 | ochoa | Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform) | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316). {ECO:0000269|PubMed:22337878, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244, ECO:0000303|PubMed:22337878}. |
| P35749 | MYH11 | S1315 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P43686 | PSMC4 | S355 | ochoa | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}. |
| P46013 | MKI67 | S425 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46940 | IQGAP1 | S1441 | ochoa|psp | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P55197 | MLLT10 | S302 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P78316 | NOP14 | S239 | ochoa | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| Q01484 | ANK2 | S2537 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01850 | CDR2 | S145 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
| Q02952 | AKAP12 | S783 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S912 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S1004 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q13061 | TRDN | S415 | ochoa | Triadin | Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}. |
| Q13427 | PPIG | S506 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13576 | IQGAP2 | S1356 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q14643 | ITPR1 | S421 | psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q15021 | NCAPD2 | S1366 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15047 | SETDB1 | S1027 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q16543 | CDC37 | S97 | psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16665 | HIF1A | S760 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q562E7 | WDR81 | S1115 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5XKL5 | BTBD8 | S597 | ochoa | BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}. |
| Q6JBY9 | RCSD1 | S267 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q7Z2T5 | TRMT1L | S703 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z2Z1 | TICRR | S1162 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z401 | DENND4A | S1117 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z7A1 | CNTRL | S2223 | ochoa | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}. |
| Q86U86 | PBRM1 | S648 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VH2 | KIF27 | S643 | ochoa | Kinesin-like protein KIF27 | Plays an essential role in motile ciliogenesis. {ECO:0000250}. |
| Q8IUD2 | ERC1 | S191 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IX01 | SUGP2 | S277 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8NDI1 | EHBP1 | S710 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NDX1 | PSD4 | S1020 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEF9 | SRFBP1 | S203 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEM2 | SHCBP1 | S574 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NI08 | NCOA7 | S502 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TF05 | PPP4R1 | S537 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| Q8TF40 | FNIP1 | S714 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8WY36 | BBX | S478 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q8WY36 | BBX | S805 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92922 | SMARCC1 | S210 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q92968 | PEX13 | S354 | ochoa | Peroxisomal membrane protein PEX13 (Peroxin-13) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:28765278, PubMed:8858165, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:28765278, PubMed:8858165, PubMed:9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:8858165, PubMed:9653144). {ECO:0000250|UniProtKB:P80667, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:8858165, ECO:0000269|PubMed:9653144}. |
| Q96BM9 | ARL8A | S150 | ochoa | ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) | Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}. |
| Q96BP3 | PPWD1 | S464 | ochoa | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:20676357}. |
| Q96EK5 | KIFBP | S178 | ochoa | KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein) | Activator of KIF1B plus-end-directed microtubule motor activity (PubMed:16225668). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. {ECO:0000269|PubMed:16225668, ECO:0000269|PubMed:20621975, ECO:0000269|PubMed:23427148}. |
| Q96JM3 | CHAMP1 | S675 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JS3 | PGBD1 | S360 | ochoa | PiggyBac transposable element-derived protein 1 (Cerebral protein 4) | None |
| Q96K83 | ZNF521 | S98 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96L93 | KIF16B | S881 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96PN7 | TRERF1 | S1072 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96QT6 | PHF12 | S131 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96T23 | RSF1 | S748 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99700 | ATXN2 | S888 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQK8 | LPIN3 | S221 | ochoa | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| Q9BRR8 | GPATCH1 | S715 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BVS4 | RIOK2 | S412 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BXW9 | FANCD2 | S886 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BZF1 | OSBPL8 | S799 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9BZV1 | UBXN6 | S252 | ochoa | UBX domain-containing protein 6 (UBX domain-containing protein 1) | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}. |
| Q9BZV2 | SLC19A3 | S472 | ochoa | Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) | Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177). {ECO:0000269|PubMed:11731220, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964, ECO:0000269|PubMed:36456177}. |
| Q9C0A6 | SETD5 | S191 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0B9 | ZCCHC2 | S490 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9GZR7 | DDX24 | S60 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H2G2 | SLK | S543 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H4A5 | GOLPH3L | S23 | ochoa | Golgi phosphoprotein 3-like (GPP34-related protein) | Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}. |
| Q9H582 | ZNF644 | S1074 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9HCE3 | ZNF532 | S130 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9NR99 | MXRA5 | S1305 | ochoa | Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) | In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}. |
| Q9NRM7 | LATS2 | S1027 | ochoa | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NS91 | RAD18 | S322 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NVJ2 | ARL8B | S150 | ochoa | ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:15331635, PubMed:16537643). In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion (PubMed:16537643, PubMed:16650381, PubMed:25898167, PubMed:27808481, PubMed:28325809). Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis (PubMed:22172677, PubMed:24088571, PubMed:29592961). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (PubMed:21802320). Recruits RUFY1 onto early endosomes regulating endosomes to trans-Golgi network proteins retrieval (PubMed:36282215). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes (PubMed:16537643, PubMed:25908847). Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (PubMed:21802320, PubMed:25908847). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:16650381, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:28325809, ECO:0000269|PubMed:29592961, ECO:0000269|PubMed:36282215}.; FUNCTION: (Microbial infection) During Mycobacterium tuberculosis (Mtb) infection, is required for plasma membrane repair by controlling the exocytosis of lysosomes in macrophages. ARL8B secretion pathway is crucial to control the type of cell death of the M.tuberculosis-infected macrophages, distinguishing avirulent from virulent Mtb induced necrotic cell death. {ECO:0000269|PubMed:29592961}.; FUNCTION: (Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress. {ECO:0000269|PubMed:33157038}. |
| Q9NZN5 | ARHGEF12 | S309 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9NZQ3 | NCKIPSD | S119 | ochoa | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| Q9P0V9 | SEPTIN10 | S427 | ochoa | Septin-10 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}. |
| Q9P2D3 | HEATR5B | S1737 | ochoa | HEAT repeat-containing protein 5B | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q9P2W9 | STX18 | S189 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UIG0 | BAZ1B | S158 | ochoa|psp | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UK61 | TASOR | S671 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKA4 | AKAP11 | S1289 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UQ88 | CDK11A | S217 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y467 | SALL2 | S797 | ochoa | Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) | Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}. |
| Q9Y5B9 | SUPT16H | S188 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y6A5 | TACC3 | S177 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6M1 | IGF2BP2 | S311 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| P35579 | MYH9 | S1308 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q12792 | TWF1 | S55 | Sugiyama | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}. |
| P30085 | CMPK1 | S47 | Sugiyama | UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}. |
| Q13347 | EIF3I | S217 | Sugiyama | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q8WX92 | NELFB | S542 | Sugiyama | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
| P35580 | MYH10 | S1315 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| Q14164 | IKBKE | S582 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q9BW91 | NUDT9 | S238 | Sugiyama | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q5VZL5 | ZMYM4 | S245 | Sugiyama | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000046 | 4.342 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000104 | 3.984 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000557 | 3.254 |
| R-HSA-69275 | G2/M Transition | 0.001065 | 2.973 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.001126 | 2.949 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001867 | 2.729 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.002168 | 2.664 |
| R-HSA-373755 | Semaphorin interactions | 0.002262 | 2.646 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.003615 | 2.442 |
| R-HSA-380287 | Centrosome maturation | 0.003939 | 2.405 |
| R-HSA-68886 | M Phase | 0.003927 | 2.406 |
| R-HSA-1640170 | Cell Cycle | 0.003931 | 2.405 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.005798 | 2.237 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.006142 | 2.212 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.007609 | 2.119 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.008571 | 2.067 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.009502 | 2.022 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.009502 | 2.022 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.010738 | 1.969 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.030095 | 1.522 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.030095 | 1.522 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.030095 | 1.522 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.030095 | 1.522 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.030095 | 1.522 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.030095 | 1.522 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.030095 | 1.522 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.030095 | 1.522 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.030095 | 1.522 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.030095 | 1.522 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.030095 | 1.522 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.037477 | 1.426 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.037477 | 1.426 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.066453 | 1.177 |
| R-HSA-4839744 | Signaling by APC mutants | 0.101459 | 0.994 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.101459 | 0.994 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.101459 | 0.994 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.101459 | 0.994 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.108302 | 0.965 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.108302 | 0.965 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.108302 | 0.965 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.108302 | 0.965 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.023841 | 1.623 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.023841 | 1.623 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.115094 | 0.939 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.115094 | 0.939 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.115094 | 0.939 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.115094 | 0.939 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.115094 | 0.939 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.026752 | 1.573 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.026752 | 1.573 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.028259 | 1.549 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.028259 | 1.549 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.121834 | 0.914 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.128524 | 0.891 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.135163 | 0.869 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.135163 | 0.869 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.050674 | 1.295 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.167612 | 0.776 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.173955 | 0.760 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.077539 | 1.110 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.223007 | 0.652 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.102979 | 0.987 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.102979 | 0.987 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.110269 | 0.958 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.169868 | 0.770 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.180251 | 0.744 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.180251 | 0.744 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.154780 | 0.810 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.154780 | 0.810 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.217037 | 0.663 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.217037 | 0.663 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.175287 | 0.756 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.039707 | 1.401 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.050674 | 1.295 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.013651 | 1.865 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.048778 | 1.312 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.018842 | 1.725 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 0.022657 | 1.645 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.148290 | 0.829 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.079759 | 1.098 |
| R-HSA-167169 | HIV Transcription Elongation | 0.050674 | 1.295 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.024296 | 1.614 |
| R-HSA-8849473 | PTK6 Expression | 0.073561 | 1.133 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.056294 | 1.250 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.013895 | 1.857 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.022368 | 1.650 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.079759 | 1.098 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.027781 | 1.556 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.130329 | 0.885 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.108302 | 0.965 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.108302 | 0.965 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.115094 | 0.939 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.121834 | 0.914 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.032977 | 1.482 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.141751 | 0.848 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.161220 | 0.793 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.064656 | 1.189 |
| R-HSA-9865881 | Complex III assembly | 0.204961 | 0.688 |
| R-HSA-72172 | mRNA Splicing | 0.029287 | 1.533 |
| R-HSA-167172 | Transcription of the HIV genome | 0.115203 | 0.939 |
| R-HSA-68877 | Mitotic Prometaphase | 0.080213 | 1.096 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.148290 | 0.829 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.049360 | 1.307 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.161220 | 0.793 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.048602 | 1.313 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.228931 | 0.640 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.077539 | 1.110 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.163293 | 0.787 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.115203 | 0.939 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.022657 | 1.645 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.066453 | 1.177 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.080615 | 1.094 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.094564 | 1.024 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.101459 | 0.994 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.108302 | 0.965 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.108302 | 0.965 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.128524 | 0.891 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.034613 | 1.461 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.041465 | 1.382 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.041465 | 1.382 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.148290 | 0.829 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.054545 | 1.263 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.054545 | 1.263 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.180251 | 0.744 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.066749 | 1.176 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.077539 | 1.110 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.204961 | 0.688 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.079759 | 1.098 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.034019 | 1.468 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.228931 | 0.640 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.156455 | 0.806 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.124489 | 0.905 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.204961 | 0.688 |
| R-HSA-9909396 | Circadian clock | 0.104964 | 0.979 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.041465 | 1.382 |
| R-HSA-2028269 | Signaling by Hippo | 0.154780 | 0.810 |
| R-HSA-4641258 | Degradation of DVL | 0.045066 | 1.346 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.223007 | 0.652 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.104964 | 0.979 |
| R-HSA-8951664 | Neddylation | 0.113909 | 0.943 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.161220 | 0.793 |
| R-HSA-4839726 | Chromatin organization | 0.056164 | 1.251 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.108302 | 0.965 |
| R-HSA-418457 | cGMP effects | 0.128524 | 0.891 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.043251 | 1.364 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.043251 | 1.364 |
| R-HSA-4641257 | Degradation of AXIN | 0.045066 | 1.346 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.045066 | 1.346 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.077539 | 1.110 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.081999 | 1.086 |
| R-HSA-5578775 | Ion homeostasis | 0.013336 | 1.875 |
| R-HSA-68875 | Mitotic Prophase | 0.083910 | 1.076 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.110269 | 0.958 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.053813 | 1.269 |
| R-HSA-162587 | HIV Life Cycle | 0.150567 | 0.822 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.125236 | 0.902 |
| R-HSA-196819 | Vitamin B1 (thiamin) metabolism | 0.101459 | 0.994 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.036281 | 1.440 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.037979 | 1.420 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.039707 | 1.401 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.039707 | 1.401 |
| R-HSA-169911 | Regulation of Apoptosis | 0.041465 | 1.382 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.154780 | 0.810 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.054545 | 1.263 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.054545 | 1.263 |
| R-HSA-9907900 | Proteasome assembly | 0.060540 | 1.218 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.073159 | 1.136 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.077539 | 1.110 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.217037 | 0.663 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.127776 | 0.894 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.183910 | 0.735 |
| R-HSA-8852135 | Protein ubiquitination | 0.132893 | 0.876 |
| R-HSA-68882 | Mitotic Anaphase | 0.035424 | 1.451 |
| R-HSA-162906 | HIV Infection | 0.041701 | 1.380 |
| R-HSA-5689603 | UCH proteinases | 0.135469 | 0.868 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.035969 | 1.444 |
| R-HSA-195721 | Signaling by WNT | 0.097528 | 1.011 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.148290 | 0.829 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.052597 | 1.279 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.052597 | 1.279 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.056519 | 1.248 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.079759 | 1.098 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.211022 | 0.676 |
| R-HSA-199991 | Membrane Trafficking | 0.140704 | 0.852 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.186499 | 0.729 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.084258 | 1.074 |
| R-HSA-9659379 | Sensory processing of sound | 0.143263 | 0.844 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.194457 | 0.711 |
| R-HSA-397014 | Muscle contraction | 0.102855 | 0.988 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.122708 | 0.911 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.122708 | 0.911 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.087826 | 1.056 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.045066 | 1.346 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.048778 | 1.312 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.048778 | 1.312 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.058517 | 1.233 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.060540 | 1.218 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.062586 | 1.204 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.186499 | 0.729 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.223007 | 0.652 |
| R-HSA-983189 | Kinesins | 0.095830 | 1.018 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.115203 | 0.939 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.069941 | 1.155 |
| R-HSA-8953854 | Metabolism of RNA | 0.063651 | 1.196 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.060540 | 1.218 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.011875 | 1.925 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.086536 | 1.063 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.089724 | 1.047 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.062586 | 1.204 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.211022 | 0.676 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.086536 | 1.063 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.132893 | 0.876 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.145882 | 0.836 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.059485 | 1.226 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.208310 | 0.681 |
| R-HSA-5576891 | Cardiac conduction | 0.103396 | 0.985 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.161796 | 0.791 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.087826 | 1.056 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.087616 | 1.057 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.101459 | 0.994 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.050674 | 1.295 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.052597 | 1.279 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.062586 | 1.204 |
| R-HSA-1483213 | Synthesis of PE | 0.223007 | 0.652 |
| R-HSA-422356 | Regulation of insulin secretion | 0.202755 | 0.693 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.098196 | 1.008 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.135163 | 0.869 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.025430 | 1.595 |
| R-HSA-9766229 | Degradation of CDH1 | 0.071001 | 1.149 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.075339 | 1.123 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.100580 | 0.997 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.046025 | 1.337 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.062586 | 1.204 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.062586 | 1.204 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.172573 | 0.763 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.049360 | 1.307 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.152365 | 0.817 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.228931 | 0.640 |
| R-HSA-373753 | Nephrin family interactions | 0.173955 | 0.760 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.079759 | 1.098 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.161432 | 0.792 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.100580 | 0.997 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.153798 | 0.813 |
| R-HSA-9758941 | Gastrulation | 0.039831 | 1.400 |
| R-HSA-8983711 | OAS antiviral response | 0.115094 | 0.939 |
| R-HSA-69541 | Stabilization of p53 | 0.048778 | 1.312 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.192700 | 0.715 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.075339 | 1.123 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.077539 | 1.110 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.120193 | 0.920 |
| R-HSA-5688426 | Deubiquitination | 0.159983 | 0.796 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.088833 | 1.051 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.082484 | 1.084 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.102979 | 0.987 |
| R-HSA-351202 | Metabolism of polyamines | 0.095830 | 1.018 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.112943 | 0.947 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.178217 | 0.749 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.122708 | 0.911 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.034613 | 1.461 |
| R-HSA-9824272 | Somitogenesis | 0.062586 | 1.204 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.125236 | 0.902 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.120193 | 0.920 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.182007 | 0.740 |
| R-HSA-162582 | Signal Transduction | 0.165711 | 0.781 |
| R-HSA-201556 | Signaling by ALK | 0.048778 | 1.312 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.071001 | 1.149 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.071001 | 1.149 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.204961 | 0.688 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.204961 | 0.688 |
| R-HSA-5619084 | ABC transporter disorders | 0.140654 | 0.852 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.186205 | 0.730 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.145215 | 0.838 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.223007 | 0.652 |
| R-HSA-4086400 | PCP/CE pathway | 0.140654 | 0.852 |
| R-HSA-202424 | Downstream TCR signaling | 0.175287 | 0.756 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.227867 | 0.642 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.125236 | 0.902 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.208310 | 0.681 |
| R-HSA-75153 | Apoptotic execution phase | 0.064656 | 1.189 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.098196 | 1.008 |
| R-HSA-422475 | Axon guidance | 0.069196 | 1.160 |
| R-HSA-9675108 | Nervous system development | 0.091570 | 1.038 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.107824 | 0.967 |
| R-HSA-5357801 | Programmed Cell Death | 0.029771 | 1.526 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.159121 | 0.798 |
| R-HSA-157118 | Signaling by NOTCH | 0.138864 | 0.857 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.164478 | 0.784 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.199984 | 0.699 |
| R-HSA-109581 | Apoptosis | 0.049934 | 1.302 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.180733 | 0.743 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.043925 | 1.357 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.135469 | 0.868 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.211093 | 0.676 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.167169 | 0.777 |
| R-HSA-69239 | Synthesis of DNA | 0.230672 | 0.637 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.233480 | 0.632 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.233480 | 0.632 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.234811 | 0.629 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.234811 | 0.629 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.234811 | 0.629 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.234811 | 0.629 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.236291 | 0.627 |
| R-HSA-202403 | TCR signaling | 0.239103 | 0.621 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.240646 | 0.619 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.240646 | 0.619 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.240646 | 0.619 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.241080 | 0.618 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.246438 | 0.608 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.246438 | 0.608 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.246438 | 0.608 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.252185 | 0.598 |
| R-HSA-1500931 | Cell-Cell communication | 0.255721 | 0.592 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.257889 | 0.589 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.257889 | 0.589 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.257889 | 0.589 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.257889 | 0.589 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.257889 | 0.589 |
| R-HSA-373760 | L1CAM interactions | 0.261647 | 0.582 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.263549 | 0.579 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.263549 | 0.579 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.263549 | 0.579 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.269167 | 0.570 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.269167 | 0.570 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.274743 | 0.561 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.274743 | 0.561 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.275754 | 0.559 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.280276 | 0.552 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.280276 | 0.552 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.280276 | 0.552 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.285767 | 0.544 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.285767 | 0.544 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.285767 | 0.544 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.285767 | 0.544 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.285767 | 0.544 |
| R-HSA-69206 | G1/S Transition | 0.289849 | 0.538 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.291217 | 0.536 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.291217 | 0.536 |
| R-HSA-69481 | G2/M Checkpoints | 0.295479 | 0.529 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.296626 | 0.528 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.296626 | 0.528 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.300266 | 0.522 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.301993 | 0.520 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.301993 | 0.520 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.301993 | 0.520 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.307320 | 0.512 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.312607 | 0.505 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.312607 | 0.505 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.312607 | 0.505 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.314267 | 0.503 |
| R-HSA-163685 | Integration of energy metabolism | 0.326309 | 0.486 |
| R-HSA-73894 | DNA Repair | 0.330677 | 0.481 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.331882 | 0.479 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.331882 | 0.479 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.333356 | 0.477 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.333356 | 0.477 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.333356 | 0.477 |
| R-HSA-774815 | Nucleosome assembly | 0.333356 | 0.477 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.333356 | 0.477 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.333356 | 0.477 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.334079 | 0.476 |
| R-HSA-6807070 | PTEN Regulation | 0.334663 | 0.475 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.334663 | 0.475 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.337441 | 0.472 |
| R-HSA-9664407 | Parasite infection | 0.337441 | 0.472 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.337441 | 0.472 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.338445 | 0.471 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.338445 | 0.471 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.338445 | 0.471 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.338445 | 0.471 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.338445 | 0.471 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.338445 | 0.471 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.338445 | 0.471 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.338445 | 0.471 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.340216 | 0.468 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.343496 | 0.464 |
| R-HSA-1483191 | Synthesis of PC | 0.343496 | 0.464 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.345755 | 0.461 |
| R-HSA-74160 | Gene expression (Transcription) | 0.349786 | 0.456 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.351279 | 0.454 |
| R-HSA-73893 | DNA Damage Bypass | 0.353484 | 0.452 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.353484 | 0.452 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.356787 | 0.448 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.356983 | 0.447 |
| R-HSA-69242 | S Phase | 0.362279 | 0.441 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.370485 | 0.431 |
| R-HSA-449147 | Signaling by Interleukins | 0.372260 | 0.429 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.373009 | 0.428 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.373009 | 0.428 |
| R-HSA-1221632 | Meiotic synapsis | 0.373009 | 0.428 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.373009 | 0.428 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.373211 | 0.428 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.373211 | 0.428 |
| R-HSA-69306 | DNA Replication | 0.375933 | 0.425 |
| R-HSA-72649 | Translation initiation complex formation | 0.377798 | 0.423 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.378649 | 0.422 |
| R-HSA-73887 | Death Receptor Signaling | 0.378649 | 0.422 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.382551 | 0.417 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.387268 | 0.412 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.387268 | 0.412 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.387268 | 0.412 |
| R-HSA-75893 | TNF signaling | 0.387268 | 0.412 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.396594 | 0.402 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.396594 | 0.402 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.396594 | 0.402 |
| R-HSA-446728 | Cell junction organization | 0.398328 | 0.400 |
| R-HSA-9033241 | Peroxisomal protein import | 0.401205 | 0.397 |
| R-HSA-191859 | snRNP Assembly | 0.401205 | 0.397 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.401205 | 0.397 |
| R-HSA-8979227 | Triglyceride metabolism | 0.401205 | 0.397 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.401205 | 0.397 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.404477 | 0.393 |
| R-HSA-9658195 | Leishmania infection | 0.404477 | 0.393 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.405780 | 0.392 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.405780 | 0.392 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.405780 | 0.392 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.406523 | 0.391 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.410321 | 0.387 |
| R-HSA-112043 | PLC beta mediated events | 0.410321 | 0.387 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.414827 | 0.382 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.414827 | 0.382 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.414827 | 0.382 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.419300 | 0.377 |
| R-HSA-8848021 | Signaling by PTK6 | 0.419300 | 0.377 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.419300 | 0.377 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.420785 | 0.376 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.424031 | 0.373 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.428143 | 0.368 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.431867 | 0.365 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.431867 | 0.365 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.431867 | 0.365 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.431867 | 0.365 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.434936 | 0.362 |
| R-HSA-112040 | G-protein mediated events | 0.436852 | 0.360 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.436852 | 0.360 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.437059 | 0.359 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.437059 | 0.359 |
| R-HSA-5218859 | Regulated Necrosis | 0.441157 | 0.355 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.449670 | 0.347 |
| R-HSA-72766 | Translation | 0.451112 | 0.346 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.453878 | 0.343 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.458054 | 0.339 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.458054 | 0.339 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.458054 | 0.339 |
| R-HSA-74259 | Purine catabolism | 0.458054 | 0.339 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.459872 | 0.337 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.462199 | 0.335 |
| R-HSA-4086398 | Ca2+ pathway | 0.462199 | 0.335 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.462199 | 0.335 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.462199 | 0.335 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.466312 | 0.331 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.470176 | 0.328 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.470393 | 0.328 |
| R-HSA-983712 | Ion channel transport | 0.472676 | 0.325 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.474444 | 0.324 |
| R-HSA-5617833 | Cilium Assembly | 0.475169 | 0.323 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.480133 | 0.319 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.482454 | 0.317 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.482454 | 0.317 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.489977 | 0.310 |
| R-HSA-6798695 | Neutrophil degranulation | 0.497664 | 0.303 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.498112 | 0.303 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.506923 | 0.295 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.506923 | 0.295 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.509546 | 0.293 |
| R-HSA-1500620 | Meiosis | 0.509546 | 0.293 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.513300 | 0.290 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.513300 | 0.290 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.513300 | 0.290 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.517025 | 0.286 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.524274 | 0.280 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.524391 | 0.280 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.533531 | 0.273 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.534549 | 0.272 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.536490 | 0.270 |
| R-HSA-2262752 | Cellular responses to stress | 0.542511 | 0.266 |
| R-HSA-418990 | Adherens junctions interactions | 0.544272 | 0.264 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.545826 | 0.263 |
| R-HSA-212436 | Generic Transcription Pathway | 0.546132 | 0.263 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.552756 | 0.257 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.556181 | 0.255 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.559581 | 0.252 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.566303 | 0.247 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.566608 | 0.247 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.569625 | 0.244 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.572923 | 0.242 |
| R-HSA-70171 | Glycolysis | 0.572923 | 0.242 |
| R-HSA-72312 | rRNA processing | 0.575322 | 0.240 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.579442 | 0.237 |
| R-HSA-15869 | Metabolism of nucleotides | 0.583909 | 0.234 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.585863 | 0.232 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.585863 | 0.232 |
| R-HSA-111885 | Opioid Signalling | 0.585863 | 0.232 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.589037 | 0.230 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.589037 | 0.230 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.592187 | 0.228 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.592187 | 0.228 |
| R-HSA-418346 | Platelet homeostasis | 0.595313 | 0.225 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.598415 | 0.223 |
| R-HSA-211000 | Gene Silencing by RNA | 0.598415 | 0.223 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.598415 | 0.223 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.598415 | 0.223 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.598777 | 0.223 |
| R-HSA-913531 | Interferon Signaling | 0.598777 | 0.223 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.601494 | 0.221 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.601494 | 0.221 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.601494 | 0.221 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.604549 | 0.219 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.607581 | 0.216 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.607581 | 0.216 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.613575 | 0.212 |
| R-HSA-421270 | Cell-cell junction organization | 0.614978 | 0.211 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.619479 | 0.208 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.622398 | 0.206 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.628168 | 0.202 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.628168 | 0.202 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.628168 | 0.202 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.631020 | 0.200 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.631020 | 0.200 |
| R-HSA-70326 | Glucose metabolism | 0.633850 | 0.198 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.633850 | 0.198 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.644959 | 0.190 |
| R-HSA-3371556 | Cellular response to heat stress | 0.644959 | 0.190 |
| R-HSA-73886 | Chromosome Maintenance | 0.644959 | 0.190 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.648029 | 0.188 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.658375 | 0.182 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.658375 | 0.182 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.658375 | 0.182 |
| R-HSA-194138 | Signaling by VEGF | 0.658375 | 0.182 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.659151 | 0.181 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.660997 | 0.180 |
| R-HSA-114608 | Platelet degranulation | 0.663600 | 0.178 |
| R-HSA-8956319 | Nucleotide catabolism | 0.668745 | 0.175 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.668803 | 0.175 |
| R-HSA-1474165 | Reproduction | 0.673812 | 0.171 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.681269 | 0.167 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.695889 | 0.157 |
| R-HSA-1483257 | Phospholipid metabolism | 0.695889 | 0.157 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.709444 | 0.149 |
| R-HSA-168249 | Innate Immune System | 0.711875 | 0.148 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.718275 | 0.144 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.720441 | 0.142 |
| R-HSA-166520 | Signaling by NTRKs | 0.720441 | 0.142 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.724724 | 0.140 |
| R-HSA-9609507 | Protein localization | 0.731026 | 0.136 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.731026 | 0.136 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.735147 | 0.134 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.735332 | 0.134 |
| R-HSA-9610379 | HCMV Late Events | 0.739206 | 0.131 |
| R-HSA-9711097 | Cellular response to starvation | 0.741212 | 0.130 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.745179 | 0.128 |
| R-HSA-597592 | Post-translational protein modification | 0.747603 | 0.126 |
| R-HSA-1266738 | Developmental Biology | 0.751388 | 0.124 |
| R-HSA-5619102 | SLC transporter disorders | 0.758593 | 0.120 |
| R-HSA-72306 | tRNA processing | 0.765941 | 0.116 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.775596 | 0.110 |
| R-HSA-611105 | Respiratory electron transport | 0.779979 | 0.108 |
| R-HSA-9824446 | Viral Infection Pathways | 0.781366 | 0.107 |
| R-HSA-168255 | Influenza Infection | 0.781674 | 0.107 |
| R-HSA-2559583 | Cellular Senescence | 0.783356 | 0.106 |
| R-HSA-382551 | Transport of small molecules | 0.783754 | 0.106 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.801030 | 0.096 |
| R-HSA-9609690 | HCMV Early Events | 0.808583 | 0.092 |
| R-HSA-428157 | Sphingolipid metabolism | 0.815852 | 0.088 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.817273 | 0.088 |
| R-HSA-168256 | Immune System | 0.818356 | 0.087 |
| R-HSA-9679506 | SARS-CoV Infections | 0.819985 | 0.086 |
| R-HSA-1280218 | Adaptive Immune System | 0.831393 | 0.080 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.831619 | 0.080 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.833495 | 0.079 |
| R-HSA-5663205 | Infectious disease | 0.853766 | 0.069 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.854060 | 0.069 |
| R-HSA-109582 | Hemostasis | 0.868198 | 0.061 |
| R-HSA-9609646 | HCMV Infection | 0.875049 | 0.058 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.887056 | 0.052 |
| R-HSA-416476 | G alpha (q) signalling events | 0.887931 | 0.052 |
| R-HSA-1643685 | Disease | 0.897761 | 0.047 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.938506 | 0.028 |
| R-HSA-392499 | Metabolism of proteins | 0.942378 | 0.026 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.948628 | 0.023 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.958204 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 0.963609 | 0.016 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.967652 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.975045 | 0.011 |
| R-HSA-388396 | GPCR downstream signalling | 0.985413 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.991813 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.999479 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999484 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999972 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.833 | 0.330 | 1 | 0.872 |
COT |
0.820 | 0.066 | 2 | 0.834 |
KIS |
0.818 | 0.288 | 1 | 0.872 |
NLK |
0.816 | 0.290 | 1 | 0.862 |
CDK1 |
0.815 | 0.360 | 1 | 0.859 |
CDK8 |
0.814 | 0.305 | 1 | 0.878 |
JNK2 |
0.813 | 0.376 | 1 | 0.844 |
CDC7 |
0.811 | -0.005 | 1 | 0.747 |
CDK2 |
0.809 | 0.318 | 1 | 0.868 |
MOS |
0.808 | 0.042 | 1 | 0.755 |
MTOR |
0.808 | 0.029 | 1 | 0.728 |
JNK3 |
0.808 | 0.348 | 1 | 0.860 |
CDK3 |
0.808 | 0.359 | 1 | 0.827 |
CDK19 |
0.807 | 0.292 | 1 | 0.859 |
CDK5 |
0.807 | 0.323 | 1 | 0.873 |
CAMK1B |
0.807 | 0.102 | -3 | 0.825 |
CLK2 |
0.806 | 0.260 | -3 | 0.688 |
CDK7 |
0.806 | 0.303 | 1 | 0.873 |
ERK5 |
0.805 | 0.132 | 1 | 0.769 |
CDK18 |
0.805 | 0.333 | 1 | 0.839 |
PRPK |
0.805 | -0.064 | -1 | 0.875 |
CAMK2G |
0.804 | 0.007 | 2 | 0.808 |
RAF1 |
0.804 | -0.048 | 1 | 0.685 |
PIM3 |
0.804 | 0.020 | -3 | 0.759 |
CLK4 |
0.804 | 0.219 | -3 | 0.719 |
SRPK1 |
0.804 | 0.142 | -3 | 0.674 |
CDK17 |
0.803 | 0.336 | 1 | 0.816 |
NDR2 |
0.803 | 0.036 | -3 | 0.765 |
GRK1 |
0.802 | 0.053 | -2 | 0.820 |
PIM1 |
0.802 | 0.115 | -3 | 0.723 |
CLK1 |
0.802 | 0.231 | -3 | 0.704 |
DSTYK |
0.802 | -0.059 | 2 | 0.846 |
P38G |
0.802 | 0.343 | 1 | 0.815 |
RSK2 |
0.802 | 0.076 | -3 | 0.702 |
DYRK2 |
0.802 | 0.273 | 1 | 0.848 |
FAM20C |
0.801 | 0.132 | 2 | 0.727 |
PRKD2 |
0.801 | 0.089 | -3 | 0.709 |
IKKB |
0.800 | -0.110 | -2 | 0.795 |
CDK16 |
0.799 | 0.369 | 1 | 0.823 |
MST4 |
0.799 | 0.063 | 2 | 0.772 |
P38B |
0.799 | 0.324 | 1 | 0.827 |
PRKD1 |
0.798 | 0.019 | -3 | 0.745 |
CDKL1 |
0.798 | 0.041 | -3 | 0.733 |
PKN3 |
0.798 | 0.026 | -3 | 0.775 |
GCN2 |
0.798 | -0.161 | 2 | 0.758 |
NDR1 |
0.798 | 0.073 | -3 | 0.771 |
PDHK4 |
0.798 | -0.172 | 1 | 0.720 |
ICK |
0.797 | 0.134 | -3 | 0.770 |
CDK13 |
0.797 | 0.282 | 1 | 0.857 |
GRK6 |
0.797 | 0.023 | 1 | 0.720 |
ATR |
0.797 | -0.031 | 1 | 0.720 |
BMPR2 |
0.797 | -0.139 | -2 | 0.881 |
CDK10 |
0.797 | 0.348 | 1 | 0.844 |
ULK2 |
0.797 | -0.122 | 2 | 0.747 |
IKKA |
0.796 | -0.055 | -2 | 0.776 |
GRK5 |
0.796 | -0.069 | -3 | 0.843 |
P38D |
0.796 | 0.332 | 1 | 0.822 |
PKN2 |
0.795 | 0.057 | -3 | 0.797 |
P70S6KB |
0.795 | 0.076 | -3 | 0.744 |
WNK1 |
0.795 | 0.063 | -2 | 0.890 |
CAMLCK |
0.795 | 0.054 | -2 | 0.893 |
DYRK4 |
0.795 | 0.307 | 1 | 0.843 |
ERK2 |
0.795 | 0.303 | 1 | 0.841 |
SKMLCK |
0.795 | 0.020 | -2 | 0.890 |
NUAK2 |
0.795 | 0.035 | -3 | 0.797 |
NIK |
0.795 | 0.049 | -3 | 0.844 |
HIPK4 |
0.794 | 0.111 | 1 | 0.821 |
SRPK2 |
0.794 | 0.107 | -3 | 0.600 |
P38A |
0.794 | 0.303 | 1 | 0.844 |
P90RSK |
0.794 | 0.034 | -3 | 0.698 |
TBK1 |
0.794 | -0.128 | 1 | 0.582 |
ERK1 |
0.794 | 0.297 | 1 | 0.821 |
CDK14 |
0.793 | 0.330 | 1 | 0.850 |
RIPK3 |
0.793 | -0.034 | 3 | 0.699 |
MAPKAPK2 |
0.792 | 0.051 | -3 | 0.656 |
CAMK2B |
0.792 | 0.076 | 2 | 0.791 |
CDKL5 |
0.792 | 0.047 | -3 | 0.721 |
PKACG |
0.792 | 0.067 | -2 | 0.830 |
IKKE |
0.792 | -0.140 | 1 | 0.583 |
TSSK2 |
0.792 | 0.082 | -5 | 0.806 |
PKCD |
0.792 | 0.054 | 2 | 0.733 |
AMPKA1 |
0.791 | 0.060 | -3 | 0.805 |
CDK9 |
0.791 | 0.282 | 1 | 0.857 |
BMPR1B |
0.791 | 0.054 | 1 | 0.715 |
AURC |
0.791 | 0.097 | -2 | 0.741 |
DAPK2 |
0.791 | 0.003 | -3 | 0.818 |
MAPKAPK3 |
0.790 | 0.027 | -3 | 0.708 |
PRKX |
0.790 | 0.149 | -3 | 0.614 |
HIPK2 |
0.790 | 0.273 | 1 | 0.822 |
ULK1 |
0.790 | -0.125 | -3 | 0.820 |
RSK3 |
0.790 | 0.015 | -3 | 0.694 |
CHAK2 |
0.789 | -0.056 | -1 | 0.868 |
CDK12 |
0.789 | 0.275 | 1 | 0.844 |
CAMK2A |
0.788 | 0.062 | 2 | 0.792 |
RSK4 |
0.788 | 0.075 | -3 | 0.660 |
PDHK1 |
0.788 | -0.209 | 1 | 0.701 |
TSSK1 |
0.788 | 0.077 | -3 | 0.820 |
ATM |
0.788 | -0.007 | 1 | 0.672 |
CAMK2D |
0.788 | -0.031 | -3 | 0.788 |
LATS2 |
0.788 | -0.011 | -5 | 0.730 |
LATS1 |
0.787 | 0.071 | -3 | 0.769 |
MLK1 |
0.787 | -0.118 | 2 | 0.754 |
MARK4 |
0.787 | -0.046 | 4 | 0.738 |
JNK1 |
0.787 | 0.299 | 1 | 0.843 |
HIPK1 |
0.787 | 0.252 | 1 | 0.857 |
DLK |
0.786 | -0.080 | 1 | 0.712 |
CAMK4 |
0.786 | 0.017 | -3 | 0.787 |
PRKD3 |
0.786 | 0.051 | -3 | 0.689 |
GRK4 |
0.786 | -0.081 | -2 | 0.826 |
PAK1 |
0.786 | 0.045 | -2 | 0.838 |
DYRK1B |
0.786 | 0.272 | 1 | 0.840 |
WNK3 |
0.786 | -0.114 | 1 | 0.651 |
AMPKA2 |
0.786 | 0.057 | -3 | 0.767 |
HUNK |
0.785 | -0.115 | 2 | 0.802 |
PKACB |
0.785 | 0.093 | -2 | 0.764 |
NEK6 |
0.785 | -0.121 | -2 | 0.840 |
DYRK1A |
0.784 | 0.206 | 1 | 0.870 |
NEK7 |
0.784 | -0.186 | -3 | 0.792 |
TGFBR1 |
0.784 | -0.012 | -2 | 0.780 |
MNK2 |
0.784 | 0.063 | -2 | 0.848 |
MSK1 |
0.784 | 0.043 | -3 | 0.671 |
MSK2 |
0.784 | -0.002 | -3 | 0.660 |
TGFBR2 |
0.784 | -0.114 | -2 | 0.772 |
GRK7 |
0.782 | 0.013 | 1 | 0.684 |
MNK1 |
0.782 | 0.098 | -2 | 0.861 |
MYLK4 |
0.782 | 0.059 | -2 | 0.838 |
MASTL |
0.782 | -0.194 | -2 | 0.827 |
ALK4 |
0.781 | -0.028 | -2 | 0.806 |
SRPK3 |
0.781 | 0.051 | -3 | 0.652 |
CDK6 |
0.781 | 0.309 | 1 | 0.839 |
NIM1 |
0.781 | -0.049 | 3 | 0.732 |
BCKDK |
0.781 | -0.148 | -1 | 0.865 |
PRP4 |
0.780 | 0.132 | -3 | 0.698 |
PKCB |
0.780 | 0.020 | 2 | 0.674 |
PAK6 |
0.780 | 0.057 | -2 | 0.769 |
MELK |
0.780 | 0.032 | -3 | 0.753 |
ALK2 |
0.780 | 0.012 | -2 | 0.793 |
RIPK1 |
0.779 | -0.138 | 1 | 0.644 |
ACVR2B |
0.779 | -0.021 | -2 | 0.781 |
PAK3 |
0.779 | -0.017 | -2 | 0.839 |
AKT2 |
0.779 | 0.062 | -3 | 0.631 |
AURB |
0.779 | 0.062 | -2 | 0.737 |
MLK2 |
0.779 | -0.122 | 2 | 0.751 |
PLK1 |
0.779 | -0.060 | -2 | 0.807 |
MLK3 |
0.778 | -0.068 | 2 | 0.683 |
DYRK3 |
0.778 | 0.198 | 1 | 0.838 |
DNAPK |
0.778 | 0.022 | 1 | 0.592 |
PKR |
0.778 | -0.031 | 1 | 0.674 |
NEK9 |
0.777 | -0.169 | 2 | 0.765 |
BMPR1A |
0.777 | 0.039 | 1 | 0.709 |
ANKRD3 |
0.777 | -0.163 | 1 | 0.695 |
CDK4 |
0.777 | 0.303 | 1 | 0.840 |
PKCG |
0.776 | -0.003 | 2 | 0.679 |
PKG2 |
0.776 | 0.061 | -2 | 0.774 |
MEK1 |
0.776 | -0.122 | 2 | 0.805 |
NUAK1 |
0.776 | -0.038 | -3 | 0.745 |
TTBK2 |
0.775 | -0.158 | 2 | 0.667 |
HIPK3 |
0.775 | 0.206 | 1 | 0.826 |
IRE1 |
0.775 | -0.086 | 1 | 0.622 |
IRE2 |
0.775 | -0.047 | 2 | 0.715 |
ACVR2A |
0.775 | -0.047 | -2 | 0.762 |
AURA |
0.774 | 0.036 | -2 | 0.699 |
DRAK1 |
0.774 | -0.003 | 1 | 0.648 |
GRK2 |
0.774 | -0.025 | -2 | 0.734 |
PIM2 |
0.774 | 0.045 | -3 | 0.691 |
CAMK1G |
0.774 | 0.043 | -3 | 0.719 |
CHK1 |
0.774 | 0.007 | -3 | 0.767 |
GSK3A |
0.774 | 0.094 | 4 | 0.464 |
BRAF |
0.774 | -0.043 | -4 | 0.525 |
VRK2 |
0.774 | -0.119 | 1 | 0.757 |
PKCH |
0.774 | 0.001 | 2 | 0.669 |
MLK4 |
0.773 | -0.095 | 2 | 0.677 |
PKCA |
0.773 | -0.014 | 2 | 0.667 |
PLK3 |
0.773 | -0.059 | 2 | 0.789 |
YSK4 |
0.773 | -0.128 | 1 | 0.638 |
MARK3 |
0.773 | -0.011 | 4 | 0.673 |
SSTK |
0.773 | 0.096 | 4 | 0.705 |
BRSK1 |
0.772 | -0.009 | -3 | 0.734 |
PAK2 |
0.772 | -0.012 | -2 | 0.822 |
SGK3 |
0.772 | 0.036 | -3 | 0.696 |
QIK |
0.772 | -0.071 | -3 | 0.790 |
SIK |
0.771 | -0.037 | -3 | 0.713 |
QSK |
0.771 | -0.058 | 4 | 0.714 |
GSK3B |
0.771 | 0.039 | 4 | 0.455 |
DCAMKL1 |
0.770 | 0.047 | -3 | 0.732 |
SMG1 |
0.770 | -0.079 | 1 | 0.670 |
CK1E |
0.769 | 0.001 | -3 | 0.586 |
MARK2 |
0.769 | -0.052 | 4 | 0.645 |
CHAK1 |
0.769 | -0.098 | 2 | 0.688 |
PHKG1 |
0.768 | -0.064 | -3 | 0.769 |
PASK |
0.768 | 0.043 | -3 | 0.773 |
BRSK2 |
0.768 | -0.033 | -3 | 0.771 |
PKCZ |
0.768 | -0.049 | 2 | 0.712 |
PKACA |
0.767 | 0.066 | -2 | 0.723 |
SMMLCK |
0.767 | 0.022 | -3 | 0.770 |
AKT1 |
0.766 | 0.046 | -3 | 0.645 |
DCAMKL2 |
0.766 | 0.018 | -3 | 0.769 |
MST3 |
0.766 | 0.013 | 2 | 0.767 |
CAMK1D |
0.766 | 0.071 | -3 | 0.630 |
PINK1 |
0.765 | -0.078 | 1 | 0.763 |
GAK |
0.765 | 0.036 | 1 | 0.705 |
MARK1 |
0.765 | -0.054 | 4 | 0.697 |
MEKK3 |
0.765 | -0.112 | 1 | 0.662 |
P70S6K |
0.765 | 0.015 | -3 | 0.647 |
CK2A2 |
0.765 | 0.015 | 1 | 0.624 |
SNRK |
0.765 | -0.122 | 2 | 0.676 |
ERK7 |
0.765 | 0.074 | 2 | 0.472 |
CK1D |
0.764 | 0.008 | -3 | 0.545 |
NEK2 |
0.764 | -0.141 | 2 | 0.735 |
ZAK |
0.764 | -0.109 | 1 | 0.670 |
MAPKAPK5 |
0.763 | -0.094 | -3 | 0.645 |
TLK2 |
0.762 | -0.163 | 1 | 0.643 |
TAO3 |
0.762 | -0.034 | 1 | 0.674 |
PLK4 |
0.761 | -0.129 | 2 | 0.643 |
DAPK3 |
0.761 | 0.050 | -3 | 0.745 |
PKCT |
0.760 | -0.027 | 2 | 0.673 |
MEKK1 |
0.760 | -0.158 | 1 | 0.671 |
MEK5 |
0.760 | -0.190 | 2 | 0.778 |
CK1A2 |
0.760 | 0.001 | -3 | 0.543 |
IRAK4 |
0.760 | -0.070 | 1 | 0.625 |
SBK |
0.759 | 0.074 | -3 | 0.513 |
PHKG2 |
0.759 | -0.019 | -3 | 0.778 |
MAK |
0.759 | 0.174 | -2 | 0.770 |
MRCKA |
0.759 | 0.095 | -3 | 0.703 |
CAMKK1 |
0.759 | -0.100 | -2 | 0.821 |
PERK |
0.758 | -0.178 | -2 | 0.821 |
HRI |
0.758 | -0.177 | -2 | 0.832 |
WNK4 |
0.758 | -0.089 | -2 | 0.860 |
GRK3 |
0.758 | -0.043 | -2 | 0.686 |
PKCE |
0.757 | 0.047 | 2 | 0.664 |
PKCI |
0.757 | -0.006 | 2 | 0.679 |
MPSK1 |
0.756 | -0.034 | 1 | 0.650 |
MEKK2 |
0.756 | -0.156 | 2 | 0.747 |
TLK1 |
0.756 | -0.156 | -2 | 0.814 |
TAO2 |
0.756 | -0.026 | 2 | 0.788 |
PAK4 |
0.755 | 0.012 | -2 | 0.713 |
PAK5 |
0.755 | 0.002 | -2 | 0.709 |
AKT3 |
0.755 | 0.050 | -3 | 0.551 |
DAPK1 |
0.755 | 0.035 | -3 | 0.727 |
CK2A1 |
0.754 | 0.006 | 1 | 0.607 |
SGK1 |
0.754 | 0.046 | -3 | 0.536 |
IRAK1 |
0.754 | -0.164 | -1 | 0.809 |
MOK |
0.754 | 0.154 | 1 | 0.793 |
NEK11 |
0.754 | -0.133 | 1 | 0.655 |
MRCKB |
0.754 | 0.080 | -3 | 0.691 |
CK1G1 |
0.753 | -0.057 | -3 | 0.579 |
NEK5 |
0.753 | -0.167 | 1 | 0.651 |
CAMKK2 |
0.752 | -0.097 | -2 | 0.823 |
CAMK1A |
0.752 | 0.052 | -3 | 0.603 |
LKB1 |
0.752 | -0.088 | -3 | 0.785 |
TTBK1 |
0.751 | -0.152 | 2 | 0.601 |
PLK2 |
0.751 | -0.036 | -3 | 0.769 |
DMPK1 |
0.750 | 0.121 | -3 | 0.722 |
ROCK2 |
0.750 | 0.084 | -3 | 0.727 |
TAK1 |
0.749 | -0.112 | 1 | 0.667 |
GCK |
0.749 | -0.053 | 1 | 0.641 |
MST2 |
0.749 | -0.105 | 1 | 0.651 |
PKN1 |
0.749 | -0.023 | -3 | 0.674 |
EEF2K |
0.749 | -0.043 | 3 | 0.813 |
NEK8 |
0.748 | -0.181 | 2 | 0.761 |
CHK2 |
0.747 | -0.016 | -3 | 0.586 |
MEKK6 |
0.746 | -0.095 | 1 | 0.656 |
TNIK |
0.746 | -0.032 | 3 | 0.840 |
HPK1 |
0.746 | -0.040 | 1 | 0.627 |
MINK |
0.745 | -0.097 | 1 | 0.623 |
HGK |
0.745 | -0.075 | 3 | 0.833 |
PDK1 |
0.745 | -0.125 | 1 | 0.647 |
LOK |
0.744 | -0.023 | -2 | 0.829 |
LRRK2 |
0.744 | -0.095 | 2 | 0.791 |
MAP3K15 |
0.744 | -0.124 | 1 | 0.651 |
NEK4 |
0.741 | -0.152 | 1 | 0.613 |
MST1 |
0.741 | -0.092 | 1 | 0.627 |
PDHK3_TYR |
0.740 | 0.144 | 4 | 0.832 |
SLK |
0.740 | -0.062 | -2 | 0.767 |
PBK |
0.740 | -0.030 | 1 | 0.614 |
CRIK |
0.740 | 0.077 | -3 | 0.634 |
VRK1 |
0.740 | -0.167 | 2 | 0.800 |
STK33 |
0.739 | -0.103 | 2 | 0.603 |
RIPK2 |
0.738 | -0.198 | 1 | 0.615 |
KHS2 |
0.738 | -0.019 | 1 | 0.628 |
ALPHAK3 |
0.737 | 0.026 | -1 | 0.805 |
KHS1 |
0.737 | -0.053 | 1 | 0.612 |
ROCK1 |
0.737 | 0.056 | -3 | 0.702 |
NEK1 |
0.736 | -0.129 | 1 | 0.626 |
PKG1 |
0.735 | 0.006 | -2 | 0.700 |
YSK1 |
0.734 | -0.099 | 2 | 0.728 |
BUB1 |
0.734 | 0.001 | -5 | 0.721 |
TESK1_TYR |
0.732 | 0.054 | 3 | 0.832 |
PDHK4_TYR |
0.732 | 0.063 | 2 | 0.854 |
MEK2 |
0.732 | -0.234 | 2 | 0.761 |
MAP2K6_TYR |
0.732 | 0.037 | -1 | 0.914 |
BMPR2_TYR |
0.732 | 0.042 | -1 | 0.906 |
OSR1 |
0.732 | -0.078 | 2 | 0.729 |
CK1A |
0.731 | -0.033 | -3 | 0.461 |
BIKE |
0.731 | -0.005 | 1 | 0.598 |
TTK |
0.728 | -0.082 | -2 | 0.805 |
EPHA6 |
0.728 | 0.028 | -1 | 0.906 |
MAP2K4_TYR |
0.727 | -0.075 | -1 | 0.899 |
HASPIN |
0.727 | -0.016 | -1 | 0.696 |
PDHK1_TYR |
0.726 | -0.032 | -1 | 0.919 |
LIMK2_TYR |
0.726 | 0.060 | -3 | 0.844 |
PKMYT1_TYR |
0.726 | -0.053 | 3 | 0.791 |
YANK3 |
0.725 | -0.057 | 2 | 0.420 |
MAP2K7_TYR |
0.724 | -0.127 | 2 | 0.831 |
NEK3 |
0.724 | -0.176 | 1 | 0.618 |
ASK1 |
0.724 | -0.139 | 1 | 0.652 |
PINK1_TYR |
0.723 | -0.110 | 1 | 0.721 |
MYO3A |
0.721 | -0.094 | 1 | 0.615 |
EPHB4 |
0.721 | -0.020 | -1 | 0.899 |
DDR1 |
0.721 | 0.006 | 4 | 0.742 |
RET |
0.719 | -0.063 | 1 | 0.674 |
TAO1 |
0.719 | -0.092 | 1 | 0.597 |
INSRR |
0.718 | -0.006 | 3 | 0.705 |
FGFR2 |
0.717 | 0.001 | 3 | 0.741 |
MYO3B |
0.717 | -0.111 | 2 | 0.746 |
LIMK1_TYR |
0.717 | -0.071 | 2 | 0.805 |
EPHA4 |
0.716 | -0.007 | 2 | 0.801 |
JAK3 |
0.716 | -0.056 | 1 | 0.674 |
TYRO3 |
0.715 | -0.114 | 3 | 0.762 |
TXK |
0.715 | -0.002 | 1 | 0.709 |
CSF1R |
0.714 | -0.104 | 3 | 0.738 |
MST1R |
0.714 | -0.118 | 3 | 0.751 |
AAK1 |
0.713 | 0.010 | 1 | 0.518 |
EPHB1 |
0.713 | -0.043 | 1 | 0.712 |
TEK |
0.712 | -0.012 | 3 | 0.703 |
ROS1 |
0.712 | -0.134 | 3 | 0.740 |
EPHB2 |
0.711 | -0.035 | -1 | 0.883 |
FGFR1 |
0.711 | -0.051 | 3 | 0.715 |
TYK2 |
0.711 | -0.217 | 1 | 0.662 |
SRMS |
0.711 | -0.072 | 1 | 0.714 |
EPHB3 |
0.710 | -0.056 | -1 | 0.888 |
FER |
0.710 | -0.134 | 1 | 0.724 |
STLK3 |
0.710 | -0.182 | 1 | 0.632 |
YES1 |
0.709 | -0.080 | -1 | 0.867 |
JAK2 |
0.709 | -0.182 | 1 | 0.677 |
ITK |
0.709 | -0.066 | -1 | 0.847 |
PDGFRB |
0.708 | -0.110 | 3 | 0.757 |
KIT |
0.708 | -0.101 | 3 | 0.739 |
FLT3 |
0.707 | -0.125 | 3 | 0.747 |
FGFR3 |
0.707 | -0.034 | 3 | 0.714 |
KDR |
0.706 | -0.064 | 3 | 0.706 |
DDR2 |
0.706 | 0.062 | 3 | 0.685 |
NEK10_TYR |
0.705 | -0.066 | 1 | 0.591 |
FLT1 |
0.704 | -0.052 | -1 | 0.900 |
EPHA7 |
0.704 | -0.049 | 2 | 0.797 |
AXL |
0.703 | -0.097 | 3 | 0.726 |
ABL2 |
0.703 | -0.127 | -1 | 0.841 |
FGR |
0.703 | -0.168 | 1 | 0.676 |
TNK2 |
0.703 | -0.100 | 3 | 0.698 |
HCK |
0.702 | -0.159 | -1 | 0.857 |
CK1G3 |
0.702 | -0.051 | -3 | 0.415 |
EPHA3 |
0.701 | -0.073 | 2 | 0.774 |
BMX |
0.701 | -0.065 | -1 | 0.743 |
EPHA5 |
0.701 | -0.028 | 2 | 0.801 |
LCK |
0.700 | -0.120 | -1 | 0.857 |
MERTK |
0.700 | -0.116 | 3 | 0.718 |
TNK1 |
0.700 | -0.088 | 3 | 0.733 |
MET |
0.700 | -0.116 | 3 | 0.725 |
PDGFRA |
0.699 | -0.163 | 3 | 0.760 |
FLT4 |
0.699 | -0.094 | 3 | 0.700 |
ABL1 |
0.699 | -0.147 | -1 | 0.831 |
TEC |
0.698 | -0.096 | -1 | 0.757 |
BLK |
0.698 | -0.088 | -1 | 0.861 |
INSR |
0.698 | -0.109 | 3 | 0.679 |
PTK2 |
0.698 | 0.012 | -1 | 0.851 |
TNNI3K_TYR |
0.698 | -0.077 | 1 | 0.671 |
NTRK1 |
0.697 | -0.152 | -1 | 0.870 |
FYN |
0.696 | -0.064 | -1 | 0.825 |
ERBB2 |
0.695 | -0.143 | 1 | 0.650 |
BTK |
0.695 | -0.191 | -1 | 0.801 |
WEE1_TYR |
0.694 | -0.109 | -1 | 0.776 |
ALK |
0.694 | -0.151 | 3 | 0.668 |
EPHA8 |
0.694 | -0.077 | -1 | 0.867 |
PTK2B |
0.694 | -0.070 | -1 | 0.797 |
EPHA1 |
0.693 | -0.125 | 3 | 0.707 |
EGFR |
0.693 | -0.071 | 1 | 0.592 |
LTK |
0.693 | -0.137 | 3 | 0.685 |
YANK2 |
0.693 | -0.072 | 2 | 0.433 |
NTRK2 |
0.692 | -0.186 | 3 | 0.698 |
JAK1 |
0.692 | -0.176 | 1 | 0.611 |
MATK |
0.692 | -0.096 | -1 | 0.767 |
SYK |
0.691 | -0.017 | -1 | 0.824 |
FRK |
0.691 | -0.148 | -1 | 0.858 |
FGFR4 |
0.690 | -0.089 | -1 | 0.821 |
PTK6 |
0.688 | -0.227 | -1 | 0.780 |
LYN |
0.688 | -0.155 | 3 | 0.657 |
EPHA2 |
0.687 | -0.064 | -1 | 0.840 |
CK1G2 |
0.687 | -0.045 | -3 | 0.505 |
NTRK3 |
0.687 | -0.162 | -1 | 0.818 |
CSK |
0.686 | -0.137 | 2 | 0.789 |
ERBB4 |
0.684 | -0.056 | 1 | 0.608 |
SRC |
0.684 | -0.133 | -1 | 0.823 |
IGF1R |
0.682 | -0.110 | 3 | 0.621 |
MUSK |
0.675 | -0.151 | 1 | 0.562 |
FES |
0.666 | -0.141 | -1 | 0.724 |
ZAP70 |
0.665 | -0.068 | -1 | 0.737 |