Motif 605 (n=313)

Position-wise Probabilities
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uniprot genes site source protein function
A4FU49 SH3D21 S217 ochoa SH3 domain-containing protein 21 None
A6NMZ7 COL6A6 S817 ochoa Collagen alpha-6(VI) chain Collagen VI acts as a cell-binding protein. {ECO:0000250}.
F8WAN1 SPECC1L-ADORA2A S220 ochoa SPECC1L-ADORA2A readthrough (NMD candidate) None
O00287 RFXAP S193 ochoa Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) Part of the RFX complex that binds to the X-box of MHC II promoters.
O00515 LAD1 S423 ochoa Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.
O00515 LAD1 S485 ochoa Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.
O00746 NME4 S153 ochoa Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:17028143, PubMed:18635542, PubMed:23150663). {ECO:0000269|PubMed:10799505, ECO:0000269|PubMed:17028143, ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:23150663, ECO:0000305, ECO:0000305|PubMed:24970086}.
O14617 AP3D1 S721 ochoa AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}.
O14777 NDC80 S44 psp Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}.
O15061 SYNM S1504 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15226 NKRF S625 ochoa NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}.
O43493 TGOLN2 S221 ochoa Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) May be involved in regulating membrane traffic to and from trans-Golgi network.
O43613 HCRTR1 S262 psp Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897). {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}.
O43815 STRN S190 ochoa Striatin Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}.
O60264 SMARCA5 S710 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O60333 KIF1B S1468 ochoa Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}.
O60361 NME2P1 S105 ochoa Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}.
O60716 CTNND1 S920 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O60939 SCN2B S192 ochoa Sodium channel regulatory subunit beta-2 Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:19808477, PubMed:23559163, PubMed:26894959). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:19808477, PubMed:23559163). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201). {ECO:0000269|PubMed:19808477, ECO:0000269|PubMed:23559163, ECO:0000269|PubMed:26894959, ECO:0000269|PubMed:30765605, ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:35277491, ECO:0000269|PubMed:36823201}.
O75151 PHF2 S853 ochoa Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
O75340 PDCD6 S107 ochoa Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250|UniProtKB:P12815, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25667979, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779, ECO:0000269|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250|UniProtKB:P12815}.
O75717 WDHD1 S394 ochoa WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
O75923 DYSF S1296 ochoa Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}.
O75976 CPD S1035 ochoa Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) None
O94875 SORBS2 S207 psp Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
O94888 UBXN7 S29 ochoa UBX domain-containing protein 7 Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}.
O94955 RHOBTB3 S32 ochoa Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.
O95490 ADGRL2 S1253 ochoa Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}.
O95684 CEP43 S326 ochoa Centrosomal protein 43 (FGFR1 oncogene partner) Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
O95999 BCL10 S171 psp B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}.
P01189 POMC S168 psp Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] [Corticotropin]: Stimulates the adrenal glands to release cortisol.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate.
P04049 RAF1 S471 psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04075 ALDOA S272 ochoa Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}.
P04083 ANXA1 S189 ochoa Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.
P05067 APP S730 psp Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
P06732 CKM S224 ochoa Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.
P06733 ENO1 S79 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P08621 SNRNP70 S117 ochoa U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.
P0DPH7 TUBA3C S48 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH7 TUBA3C S379 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D S48 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D S379 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P10398 ARAF S432 psp Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P12259 F5 S1533 ochoa Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
P12268 IMPDH2 S426 ochoa Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.
P12814 ACTN1 S763 ochoa Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}.
P12883 MYH7 S210 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P15056 BRAF S579 psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P15531 NME1 S120 ochoa|psp Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.
P16157 ANK1 S960 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P19784 CSNK2A2 S21 ochoa Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}.
P20309 CHRM3 S386 ochoa Muscarinic acetylcholine receptor M3 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}.
P21554 CNR1 S316 ochoa Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712). {ECO:0000250|UniProtKB:O02777, ECO:0000250|UniProtKB:P47746, ECO:0000269|PubMed:15620723, ECO:0000269|PubMed:1718258, ECO:0000269|PubMed:17895407, ECO:0000269|PubMed:21895628, ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}.; FUNCTION: [Isoform 1]: Binds both 2-arachidonoylglycerol (2-AG) and anandamide. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 2]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 3]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.
P22392 NME2 S120 ochoa Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.
P22694 PRKACB S326 ochoa cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}.
P22732 SLC2A5 S482 ochoa Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5) Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}.
P25440 BRD2 S397 ochoa Bromodomain-containing protein 2 (O27.1.1) Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}.
P25786 PSMA1 S230 ochoa Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P28290 ITPRID2 S385 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P28370 SMARCA1 S725 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
P28799 GRN S81 psp Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}.
P28827 PTPRM S790 ochoa Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}.
P30101 PDIA3 S163 ochoa Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
P32929 CTH S377 psp Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}.
P33981 TTK S362 psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35716 SOX11 S71 ochoa Transcription factor SOX-11 Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}.
P37275 ZEB1 S342 ochoa Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
P40227 CCT6A S94 ochoa T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P41587 VIPR2 S409 ochoa Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C. {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:7811244, ECO:0000269|PubMed:8933357}.
P42858 HTT S2114 psp Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.
P43686 PSMC4 S28 ochoa 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}.
P46199 MTIF2 S426 ochoa Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt)) One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
P46821 MAP1B S1988 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48444 ARCN1 S253 ochoa Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
P49790 NUP153 S1047 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P49792 RANBP2 S1422 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S1486 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S1613 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S3137 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49916 LIG3 S848 ochoa DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
P50851 LRBA S1231 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51587 BRCA2 S253 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P54296 MYOM2 S192 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55197 MLLT10 S276 ochoa Protein AF-10 (ALL1-fused gene from chromosome 10 protein) Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.
P58317 ZNF121 S87 ochoa Zinc finger protein 121 (Zinc finger protein 20) May be involved in transcriptional regulation.
P60228 EIF3E S399 ochoa Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
P61106 RAB14 S180 ochoa Ras-related protein Rab-14 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22595670). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (PubMed:22595670). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (PubMed:20534812). Interaction with RAB11FIP1 may function in the process of neurite formation (PubMed:26032412). {ECO:0000250|UniProtKB:P61107, ECO:0000250|UniProtKB:Q91V41, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:22595670, ECO:0000269|PubMed:26032412}.
P61601 NCALD S143 ochoa Neurocalcin-delta May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
P62937 PPIA S77 ochoa Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}.
P68363 TUBA1B S48 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68363 TUBA1B S379 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A S48 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P68366 TUBA4A S379 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78504 JAG1 S1101 ochoa Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:20437614, ECO:0000269|PubMed:9462510}.
P84074 HPCA S143 ochoa Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2) Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}.
P98175 RBM10 S842 ochoa RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}.
Q02224 CENPE S611 ochoa Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}.
Q02241 KIF23 S889 ochoa Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}.
Q02790 FKBP4 S78 ochoa Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Q03001 DST S6192 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03164 KMT2A S912 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05209 PTPN12 S713 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q06945 SOX4 S81 ochoa Transcription factor SOX-4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}.
Q07021 C1QBP S201 ochoa Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}.
Q07065 CKAP4 S232 ochoa Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}.
Q08945 SSRP1 S349 ochoa FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}.
Q09666 AHNAK S440 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S3031 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12830 BPTF S2682 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q13007 IL24 S88 psp Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}.
Q13023 AKAP6 S1983 ochoa A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Q13131 PRKAA1 S172 psp 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
Q13495 MAMLD1 S190 ochoa Mastermind-like domain-containing protein 1 (F18) (Protein CG1) Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}.
Q14005 IL16 S863 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14008 CKAP5 S1983 ochoa Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.
Q14116 IL18 S35 ochoa Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993714}.
Q14118 DAG1 S814 ochoa Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}.
Q14149 MORC3 S771 ochoa MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}.
Q14517 FAT1 S4353 ochoa Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.
Q14847 LASP1 S118 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q15008 PSMD6 S361 ochoa 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.
Q15054 POLD3 S407 ochoa DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}.
Q15058 KIF14 S101 ochoa Kinesin-like protein KIF14 Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}.
Q16236 NFE2L2 S40 psp Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.
Q16665 HIF1A S760 psp Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}.
Q2KHR3 QSER1 S1257 ochoa Glutamine and serine-rich protein 1 Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}.
Q2M1Z3 ARHGAP31 S388 ochoa Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.
Q562F6 SGO2 S774 ochoa Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}.
Q5JSH3 WDR44 S71 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5SYE7 NHSL1 S198 ochoa NHS-like protein 1 None
Q5T5X7 BEND3 S33 ochoa BEN domain-containing protein 3 Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.
Q5T8I3 EEIG2 S317 ochoa EEIG family member 2 (EEIG2) None
Q5VU43 PDE4DIP S726 ochoa Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.
Q5VUA4 ZNF318 S1761 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q685J3 MUC17 S4428 ochoa Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3) Probably plays a role in maintaining homeostasis on mucosal surfaces. {ECO:0000269|PubMed:17990980}.
Q69YQ0 SPECC1L S220 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q69YZ2 TMEM200B S260 ochoa Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B) None
Q6F5E8 CARMIL2 S1176 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6IQ55 TTBK2 S445 ochoa Tau-tubulin kinase 2 (EC 2.7.11.1) Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}.
Q6P499 NIPAL3 S359 ochoa NIPA-like protein 3 None
Q6PEY2 TUBA3E S48 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PJG2 MIDEAS S894 ochoa Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) None
Q6PL18 ATAD2 S25 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6WCQ1 MPRIP S540 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6YHU6 THADA S1031 ochoa tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein) Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. {ECO:0000269|PubMed:25404562}.
Q6YP21 KYAT3 S76 ochoa Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). {ECO:0000250|UniProtKB:Q71RI9}.
Q6ZT07 TBC1D9 S415 ochoa TBC1 domain family member 9 (TBC1 domain family member 9A) May act as a GTPase-activating protein for Rab family protein(s).
Q6ZV29 PNPLA7 S1258 ochoa Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}.
Q71U36 TUBA1A S48 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q71U36 TUBA1A S379 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q76I76 SSH2 S784 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q7L9B9 EEPD1 S31 ochoa Endonuclease/exonuclease/phosphatase family domain-containing protein 1 None
Q7Z2T5 TRMT1L S703 ochoa tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}.
Q7Z2W7 TRPM8 S1041 psp Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186). {ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:15306801, ECO:0000269|PubMed:15852009, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:25559186, ECO:0000269|PubMed:37857704}.; FUNCTION: [Isoform 2]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}.; FUNCTION: [Isoform 3]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}.
Q7Z3J2 VPS35L S108 ochoa VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein) Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.
Q7Z3T8 ZFYVE16 S193 ochoa Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.
Q7Z3T8 ZFYVE16 S218 ochoa Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.
Q7Z401 DENND4A S922 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z401 DENND4A S1117 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z5J4 RAI1 S637 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z5K2 WAPL S130 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q86UW6 N4BP2 S854 ochoa NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}.
Q8IUX4 APOBEC3F S216 psp DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:15141007, PubMed:20062055, PubMed:22915799, PubMed:34774569). Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 (PubMed:15141007, PubMed:15152192, PubMed:20219927, PubMed:21835787, PubMed:22807680, PubMed:23001005, PubMed:23097438, PubMed:23152537, PubMed:34774569). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:15141007). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells (PubMed:15141007). Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (PubMed:15141007). Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons (PubMed:16378963, PubMed:16527742, PubMed:19458006, PubMed:20062055, PubMed:20335265). May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:15141007, ECO:0000269|PubMed:15152192, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23001005, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537, ECO:0000269|PubMed:34774569}.
Q8IVF2 AHNAK2 S4781 ochoa Protein AHNAK2 None
Q8IVF2 AHNAK2 S5542 ochoa Protein AHNAK2 None
Q8IW35 CEP97 S445 ochoa Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}.
Q8IWB9 TEX2 S538 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IX90 SKA3 S248 ochoa Spindle and kinetochore-associated protein 3 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}.
Q8IY92 SLX4 S1204 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8N1F7 NUP93 S72 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N392 ARHGAP18 S191 ochoa Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}.
Q8N554 ZNF276 S360 ochoa Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) May be involved in transcriptional regulation.
Q8N5P1 ZC3H8 S86 ochoa Zinc finger CCCH domain-containing protein 8 Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.
Q8N8F7 LSMEM1 S38 ochoa Leucine-rich single-pass membrane protein 1 None
Q8NEU8 APPL2 S329 ochoa DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:15016378, PubMed:24879834, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:24879834). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity) (PubMed:19433865). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.
Q8NEV8 EXPH5 S1707 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NF91 SYNE1 S8277 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NF91 SYNE1 S8325 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NF91 SYNE1 S8358 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NFC6 BOD1L1 S1615 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8NG27 PJA1 S120 ochoa E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}.
Q8TF47 ZFP90 S434 ochoa Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}.
Q8WU20 FRS2 S300 ochoa Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Q8WUM0 NUP133 S480 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WUM9 SLC20A1 S472 ochoa Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.
Q8WVC0 LEO1 S110 psp RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}.
Q8WW12 PCNP S156 ochoa PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) May be involved in cell cycle regulation.
Q8WWH5 TRUB1 S211 ochoa Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}.
Q8WWI1 LMO7 S540 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WXA9 SREK1 S171 ochoa Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}.
Q8WYP5 AHCTF1 S1908 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92502 STARD8 S506 ochoa StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}.
Q92576 PHF3 S97 ochoa PHD finger protein 3 None
Q92785 DPF2 S113 ochoa Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.
Q92786 PROX1 S291 ochoa Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
Q92835 INPP5D S27 psp Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.
Q92956 TNFRSF14 S240 ochoa Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270) Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:10754304, PubMed:18193050, PubMed:23761635, PubMed:9462508). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity) (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity) (PubMed:19915044). {ECO:0000250|UniProtKB:Q80WM9, ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9462508}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:8898196, ECO:0000269|PubMed:9696799}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.
Q93073 SECISBP2L S885 ochoa Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.
Q96GG9 DCUN1D1 S59 ochoa DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250|UniProtKB:Q9QZ73, ECO:0000269|PubMed:18826954, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:23401859, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:28581483}.
Q96GX5 MASTL S593 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96MU7 YTHDC1 S588 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96N46 TTC14 S546 ochoa Tetratricopeptide repeat protein 14 (TPR repeat protein 14) None
Q96PU4 UHRF2 S681 ochoa E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}.
Q96RL7 VPS13A S833 ochoa Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:34830155}.
Q96SD1 DCLRE1C S538 psp Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}.
Q96SN8 CDK5RAP2 S841 ochoa CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}.
Q96T23 RSF1 S660 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q96T88 UHRF1 S172 ochoa E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}.
Q99426 TBCB S128 psp Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.
Q99541 PLIN2 S300 ochoa Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. {ECO:0000269|PubMed:34077757}.
Q99801 NKX3-1 S185 psp Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
Q99848 EBNA1BP2 S207 ochoa Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) Required for the processing of the 27S pre-rRNA. {ECO:0000250}.
Q9BQE3 TUBA1C S48 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BRS2 RIOK1 S416 ochoa Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}.
Q9BRU9 UTP23 S174 ochoa rRNA-processing protein UTP23 homolog Involved in rRNA-processing and ribosome biogenesis. {ECO:0000250}.
Q9BV44 THUMPD3 S207 ochoa tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-) Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960). {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}.
Q9BWM7 SFXN3 S291 ochoa Sideroflexin-3 Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}.
Q9BX63 BRIP1 S917 ochoa Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}.
Q9BY12 SCAPER S294 ochoa S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}.
Q9BYM8 RBCK1 S331 ochoa RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9BYW2 SETD2 S803 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BZD6 PRRG4 S163 ochoa Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}.
Q9H0H5 RACGAP1 S206 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H116 GZF1 S265 ochoa GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}.
Q9H1E3 NUCKS1 S73 ochoa Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}.
Q9H4G0 EPB41L1 S69 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H4L7 SMARCAD1 S124 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H6A9 PCNX3 S95 ochoa Pecanex-like protein 3 (Pecanex homolog protein 3) None
Q9H6T3 RPAP3 S116 ochoa|psp RNA polymerase II-associated protein 3 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.
Q9H6U6 BCAS3 S461 ochoa BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9H6V9 LDAH S98 ochoa Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) (hLDAH) Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity). {ECO:0000250|UniProtKB:Q8BVA5, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}.
Q9H6X5 C19orf44 S239 ochoa Uncharacterized protein C19orf44 None
Q9H765 ASB8 S31 psp Ankyrin repeat and SOCS box protein 8 (ASB-8) May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation (PubMed:32298923). {ECO:0000269|PubMed:32298923}.
Q9H792 PEAK1 S662 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9H8H3 TMT1A S69 ochoa Thiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A) Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:34980213, ECO:0000269|PubMed:37137720}.; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. {ECO:0000269|PubMed:26185986}.
Q9H9A5 CNOT10 S20 ochoa CCR4-NOT transcription complex subunit 10 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}.
Q9HC77 CPAP S595 psp Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}.
Q9HCJ3 RAVER2 S622 ochoa Ribonucleoprotein PTB-binding 2 (Protein raver-2) May bind single-stranded nucleic acids. {ECO:0000305}.
Q9HCK1 ZDBF2 S631 ochoa DBF4-type zinc finger-containing protein 2 None
Q9HD20 ATP13A1 S935 ochoa Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}.
Q9NQL2 RRAGD S96 ochoa Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279). In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34607910}.
Q9NQW6 ANLN S678 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NQZ2 UTP3 S365 ochoa Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}.
Q9NR80 ARHGEF4 S65 ochoa Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.
Q9NR99 MXRA5 S1304 ochoa Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}.
Q9NSY0 NRBP2 S209 ochoa Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}.
Q9NY65 TUBA8 S379 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9NYQ6 CELSR1 S2867 ochoa Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9NZJ0 DTL S535 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9P1Z0 ZBTB4 S391 ochoa Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}.
Q9P2D1 CHD7 S2275 ochoa Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}.
Q9UBW5 BIN2 S90 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UDY2 TJP2 S394 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UEW8 STK39 S323 psp STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}.
Q9UGP4 LIMD1 S656 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UHR4 BAIAP2L1 S395 ochoa BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.
Q9UHW9 SLC12A6 S93 ochoa Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.
Q9UIF8 BAZ2B S1269 ochoa Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}.
Q9UJ90 KCNE5 S95 ochoa Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein) Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.
Q9UK76 JPT1 S49 ochoa Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}.
Q9ULD2 MTUS1 S279 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9ULU8 CADPS S377 ochoa Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.
Q9UMZ2 SYNRG S822 ochoa Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}.
Q9UPN4 CEP131 S499 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UPQ0 LIMCH1 S327 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UPZ3 HPS5 S701 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9UQM7 CAMK2A S257 ochoa Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
Q9Y2K1 ZBTB1 S355 ochoa Zinc finger and BTB domain-containing protein 1 Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}.
Q9Y343 SNX24 S116 ochoa Sorting nexin-24 May be involved in several stages of intracellular trafficking. {ECO:0000250}.
Q9Y3E5 PTRH2 S57 ochoa Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269|PubMed:14660562, ECO:0000269|PubMed:15006356}.
Q9Y3R5 DOP1B S580 ochoa Protein DOP1B May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q9Y520 PRRC2C S1983 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y6I4 USP3 S350 ochoa Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}.
Q9Y6K1 DNMT3A S393 psp DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.
P05787 KRT8 S280 Sugiyama Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.
P34932 HSPA4 S363 Sugiyama Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
Q86UE8 TLK2 S686 EPSD|PSP Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}.
Q9UKI8 TLK1 S679 EPSD|PSP Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
P63220 RPS21 S31 Sugiyama Small ribosomal subunit protein eS21 (40S ribosomal protein S21) Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}.
Q12792 TWF1 S55 Sugiyama Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.
P23381 WARS1 S378 Sugiyama Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.
Q2TAL8 QRICH1 S33 Sugiyama Transcriptional regulator QRICH1 (Glutamine-rich protein 1) Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}.
Q02809 PLOD1 S346 Sugiyama Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). {ECO:0000250|UniProtKB:Q9R0E2, ECO:0000269|PubMed:10686424, ECO:0000269|PubMed:15854030, ECO:0000269|PubMed:8621606, ECO:0000305}.
P13639 EEF2 S578 Sugiyama Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
O94806 PRKD3 S452 Sugiyama Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O95602 POLR1A S240 Sugiyama DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
Q13085 ACACA S1766 Sugiyama Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.
Q99832 CCT7 S96 Sugiyama T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
Q13972 RASGRF1 S287 SIGNOR Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}.
P11279 LAMP1 S335 Sugiyama Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.
P15735 PHKG2 S175 Sugiyama Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}.
P17612 PRKACA S326 GPS6 cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.
P47756 CAPZB S90 Sugiyama F-actin-capping protein subunit beta (CapZ beta) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}.
O95273 CCNDBP1 S313 GPS6 Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid) May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. {ECO:0000269|PubMed:10801854}.
P36888 FLT3 S735 Sugiyama Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.
Q9Y4K0 LOXL2 S411 Sugiyama Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:24414204, PubMed:27735137). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P58022, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20026874, ECO:0000269|PubMed:20306300, ECO:0000269|PubMed:21835952, ECO:0000269|PubMed:24239292, ECO:0000269|PubMed:24414204, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:27735137}.
P51617 IRAK1 S213 Sugiyama Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P49917 LIG4 S672 SIGNOR DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:12517771, PubMed:17290226, PubMed:23523427, PubMed:29980672, PubMed:33586762, PubMed:8798671, PubMed:9242410, PubMed:9809069). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226). Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069). Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421). LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242). {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:23523427, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:29980672, ECO:0000269|PubMed:33586762, ECO:0000269|PubMed:8798671, ECO:0000269|PubMed:9242410, ECO:0000269|PubMed:9809069}.
P30101 PDIA3 S343 Sugiyama Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
Q96J02 ITCH S162 SIGNOR E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}.
Q8IVD9 NUDCD3 S193 Sugiyama NudC domain-containing protein 3 None
O14910 LIN7A S157 Sugiyama Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
Q15418 RPS6KA1 S539 Sugiyama Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.
Q9NUP9 LIN7C S142 Sugiyama Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.
P50395 GDI2 S43 Sugiyama Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.
Q9Y2L1 DIS3 S223 Sugiyama Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}.
Q16816 PHKG1 S172 Sugiyama Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}.
Q09028 RBBP4 S159 Sugiyama Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}.
P13674 P4HA1 S383 Sugiyama Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.
P49792 RANBP2 S1550 Sugiyama E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
Q96PF2 TSSK2 S258 Sugiyama Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.
Q9NPF0 CD320 S81 Sugiyama CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389, ECO:0000269|PubMed:20524213}.
Q9UK32 RPS6KA6 S547 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
Download
reactome_id name p -log10_p
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 6.619838e-11 10.179
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.459411e-11 10.263
R-HSA-438064 Post NMDA receptor activation events 3.405146e-10 9.468
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 5.847627e-10 9.233
R-HSA-68877 Mitotic Prometaphase 1.208155e-09 8.918
R-HSA-68886 M Phase 2.727617e-09 8.564
R-HSA-389977 Post-chaperonin tubulin folding pathway 4.257452e-09 8.371
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.031382e-08 7.987
R-HSA-2467813 Separation of Sister Chromatids 1.513068e-08 7.820
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.570663e-08 7.590
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2.885952e-08 7.540
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.944179e-08 7.531
R-HSA-983189 Kinesins 3.026986e-08 7.519
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.862439e-08 7.413
R-HSA-190872 Transport of connexons to the plasma membrane 4.045258e-08 7.393
R-HSA-9619483 Activation of AMPK downstream of NMDARs 5.758184e-08 7.240
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.816235e-08 7.235
R-HSA-68882 Mitotic Anaphase 1.783025e-07 6.749
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.904612e-07 6.720
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 2.320779e-07 6.634
R-HSA-391251 Protein folding 3.278318e-07 6.484
R-HSA-437239 Recycling pathway of L1 3.292461e-07 6.482
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.551976e-07 6.450
R-HSA-69275 G2/M Transition 4.474305e-07 6.349
R-HSA-453274 Mitotic G2-G2/M phases 5.134405e-07 6.290
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.569986e-07 6.254
R-HSA-1640170 Cell Cycle 6.719084e-07 6.173
R-HSA-5610787 Hedgehog 'off' state 8.338466e-07 6.079
R-HSA-69278 Cell Cycle, Mitotic 9.107967e-07 6.041
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 9.608325e-07 6.017
R-HSA-390466 Chaperonin-mediated protein folding 1.134735e-06 5.945
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 2.076332e-06 5.683
R-HSA-190861 Gap junction assembly 2.989065e-06 5.524
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 3.169148e-06 5.499
R-HSA-8856688 Golgi-to-ER retrograde transport 3.715411e-06 5.430
R-HSA-112315 Transmission across Chemical Synapses 4.174248e-06 5.379
R-HSA-373760 L1CAM interactions 4.585407e-06 5.339
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 5.707148e-06 5.244
R-HSA-9646399 Aggrephagy 8.008265e-06 5.096
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 8.786953e-06 5.056
R-HSA-5617833 Cilium Assembly 1.067980e-05 4.971
R-HSA-190828 Gap junction trafficking 1.644633e-05 4.784
R-HSA-6807878 COPI-mediated anterograde transport 1.925144e-05 4.716
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.875057e-05 4.727
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 2.441941e-05 4.612
R-HSA-5358351 Signaling by Hedgehog 2.851357e-05 4.545
R-HSA-157858 Gap junction trafficking and regulation 3.135946e-05 4.504
R-HSA-2132295 MHC class II antigen presentation 3.822325e-05 4.418
R-HSA-9663891 Selective autophagy 4.475630e-05 4.349
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.294029e-05 4.276
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 6.104642e-05 4.214
R-HSA-5610780 Degradation of GLI1 by the proteasome 8.779394e-05 4.057
R-HSA-9612973 Autophagy 9.049565e-05 4.043
R-HSA-9010642 ROBO receptors bind AKAP5 9.264989e-05 4.033
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.417027e-04 3.849
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.417027e-04 3.849
R-HSA-1632852 Macroautophagy 1.442502e-04 3.841
R-HSA-8854518 AURKA Activation by TPX2 1.870915e-04 3.728
R-HSA-1280215 Cytokine Signaling in Immune system 2.027156e-04 3.693
R-HSA-199977 ER to Golgi Anterograde Transport 2.136188e-04 3.670
R-HSA-112316 Neuronal System 2.790349e-04 3.554
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.888913e-04 3.539
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.096123e-04 3.509
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 3.405788e-04 3.468
R-HSA-380287 Centrosome maturation 3.995667e-04 3.398
R-HSA-422475 Axon guidance 3.860068e-04 3.413
R-HSA-9833482 PKR-mediated signaling 5.840176e-04 3.234
R-HSA-5610783 Degradation of GLI2 by the proteasome 6.262504e-04 3.203
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 6.262504e-04 3.203
R-HSA-70171 Glycolysis 6.082718e-04 3.216
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 6.673856e-04 3.176
R-HSA-9609690 HCMV Early Events 6.694388e-04 3.174
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 7.765710e-04 3.110
R-HSA-9675108 Nervous system development 9.443818e-04 3.025
R-HSA-5620924 Intraflagellar transport 1.237612e-03 2.907
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.264260e-03 2.898
R-HSA-9012546 Interleukin-18 signaling 1.657255e-03 2.781
R-HSA-9660537 Signaling by MRAS-complex mutants 1.657255e-03 2.781
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.657255e-03 2.781
R-HSA-392517 Rap1 signalling 1.700671e-03 2.769
R-HSA-70326 Glucose metabolism 1.892385e-03 2.723
R-HSA-111933 Calmodulin induced events 2.210492e-03 2.656
R-HSA-111997 CaM pathway 2.210492e-03 2.656
R-HSA-8853659 RET signaling 2.210492e-03 2.656
R-HSA-1852241 Organelle biogenesis and maintenance 2.298050e-03 2.639
R-HSA-449147 Signaling by Interleukins 2.375869e-03 2.624
R-HSA-948021 Transport to the Golgi and subsequent modification 2.576554e-03 2.589
R-HSA-390450 Folding of actin by CCT/TriC 2.653454e-03 2.576
R-HSA-1280218 Adaptive Immune System 2.996205e-03 2.523
R-HSA-446652 Interleukin-1 family signaling 3.294408e-03 2.482
R-HSA-163765 ChREBP activates metabolic gene expression 3.264082e-03 2.486
R-HSA-109582 Hemostasis 3.085037e-03 2.511
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 3.411637e-03 2.467
R-HSA-5621575 CD209 (DC-SIGN) signaling 3.769724e-03 2.424
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.830935e-03 2.417
R-HSA-141424 Amplification of signal from the kinetochores 3.830935e-03 2.417
R-HSA-111996 Ca-dependent events 4.182008e-03 2.379
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.381938e-03 2.358
R-HSA-8941856 RUNX3 regulates NOTCH signaling 4.726597e-03 2.325
R-HSA-9609646 HCMV Infection 4.757949e-03 2.323
R-HSA-1489509 DAG and IP3 signaling 5.324537e-03 2.274
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 5.584080e-03 2.253
R-HSA-8963896 HDL assembly 6.528985e-03 2.185
R-HSA-162582 Signal Transduction 6.557470e-03 2.183
R-HSA-168256 Immune System 6.861795e-03 2.164
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 7.100127e-03 2.149
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 7.796858e-03 2.108
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 7.796858e-03 2.108
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 8.241481e-03 2.084
R-HSA-3371556 Cellular response to heat stress 7.847172e-03 2.105
R-HSA-8878159 Transcriptional regulation by RUNX3 7.950574e-03 2.100
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 8.689316e-03 2.061
R-HSA-162909 Host Interactions of HIV factors 8.878752e-03 2.052
R-HSA-69618 Mitotic Spindle Checkpoint 9.146721e-03 2.039
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 9.321805e-03 2.030
R-HSA-1855170 IPs transport between nucleus and cytosol 9.321805e-03 2.030
R-HSA-159227 Transport of the SLBP independent Mature mRNA 9.321805e-03 2.030
R-HSA-9006925 Intracellular signaling by second messengers 9.535292e-03 2.021
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.015205e-02 1.993
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1.102876e-02 1.957
R-HSA-5673000 RAF activation 1.102876e-02 1.957
R-HSA-114608 Platelet degranulation 1.040782e-02 1.983
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 1.015205e-02 1.993
R-HSA-2262752 Cellular responses to stress 1.047567e-02 1.980
R-HSA-180746 Nuclear import of Rev protein 1.102876e-02 1.957
R-HSA-8953897 Cellular responses to stimuli 1.152678e-02 1.938
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 1.195285e-02 1.923
R-HSA-2980766 Nuclear Envelope Breakdown 1.211436e-02 1.917
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 1.394654e-02 1.856
R-HSA-5674499 Negative feedback regulation of MAPK pathway 1.230536e-02 1.910
R-HSA-163615 PKA activation 1.263087e-02 1.899
R-HSA-164378 PKA activation in glucagon signalling 1.263087e-02 1.899
R-HSA-180910 Vpr-mediated nuclear import of PICs 1.394654e-02 1.856
R-HSA-199991 Membrane Trafficking 1.338544e-02 1.873
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 1.378808e-02 1.860
R-HSA-5687128 MAPK6/MAPK4 signaling 1.384771e-02 1.859
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.501774e-02 1.823
R-HSA-112043 PLC beta mediated events 1.528930e-02 1.816
R-HSA-9818749 Regulation of NFE2L2 gene expression 1.536442e-02 1.813
R-HSA-163685 Integration of energy metabolism 1.561512e-02 1.806
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 1.613950e-02 1.792
R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.613950e-02 1.792
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 1.731250e-02 1.762
R-HSA-177243 Interactions of Rev with host cellular proteins 1.731250e-02 1.762
R-HSA-176033 Interactions of Vpr with host cellular proteins 1.731250e-02 1.762
R-HSA-111931 PKA-mediated phosphorylation of CREB 1.744168e-02 1.758
R-HSA-9702506 Drug resistance of FLT3 mutants 2.052848e-02 1.688
R-HSA-9702509 FLT3 mutants bind TKIs 2.052848e-02 1.688
R-HSA-9702614 ponatinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702605 pexidartinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702596 lestaurtinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702620 quizartinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9703009 tamatinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702569 KW2449-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702632 sunitinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702600 midostaurin-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702998 linifanib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702581 crenolanib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702624 sorafenib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702636 tandutinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702590 gilteritinib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9702577 semaxanib-resistant FLT3 mutants 2.052848e-02 1.688
R-HSA-9656223 Signaling by RAF1 mutants 1.981472e-02 1.703
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.897721e-02 1.722
R-HSA-1234174 Cellular response to hypoxia 1.897721e-02 1.722
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 1.853737e-02 1.732
R-HSA-5621481 C-type lectin receptors (CLRs) 1.898462e-02 1.722
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.853737e-02 1.732
R-HSA-9909648 Regulation of PD-L1(CD274) expression 1.955776e-02 1.709
R-HSA-376176 Signaling by ROBO receptors 1.886938e-02 1.724
R-HSA-112040 G-protein mediated events 2.102267e-02 1.677
R-HSA-444257 RSK activation 2.233986e-02 1.651
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 2.233986e-02 1.651
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 2.700614e-02 1.569
R-HSA-9649948 Signaling downstream of RAS mutants 2.700614e-02 1.569
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 2.700614e-02 1.569
R-HSA-6798695 Neutrophil degranulation 2.337693e-02 1.631
R-HSA-6802949 Signaling by RAS mutants 2.700614e-02 1.569
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 2.545910e-02 1.594
R-HSA-1474290 Collagen formation 2.251085e-02 1.648
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 2.435186e-02 1.613
R-HSA-5683057 MAPK family signaling cascades 2.262807e-02 1.645
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 2.700614e-02 1.569
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 2.674951e-02 1.573
R-HSA-8963898 Plasma lipoprotein assembly 2.523622e-02 1.598
R-HSA-5693532 DNA Double-Strand Break Repair 2.784437e-02 1.555
R-HSA-9013694 Signaling by NOTCH4 2.929271e-02 1.533
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.972695e-02 1.527
R-HSA-8951664 Neddylation 3.069466e-02 1.513
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 3.186321e-02 1.497
R-HSA-9766229 Degradation of CDH1 3.197890e-02 1.495
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 3.211983e-02 1.493
R-HSA-69620 Cell Cycle Checkpoints 3.241524e-02 1.489
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 3.258898e-02 1.487
R-HSA-111885 Opioid Signalling 3.423879e-02 1.465
R-HSA-162906 HIV Infection 3.532756e-02 1.452
R-HSA-1169091 Activation of NF-kappaB in B cells 3.557278e-02 1.449
R-HSA-180024 DARPP-32 events 3.719801e-02 1.429
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.745382e-02 1.427
R-HSA-6794361 Neurexins and neuroligins 3.745382e-02 1.427
R-HSA-68884 Mitotic Telophase/Cytokinesis 3.936672e-02 1.405
R-HSA-162592 Integration of provirus 3.936672e-02 1.405
R-HSA-8948751 Regulation of PTEN stability and activity 3.939104e-02 1.405
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 4.063678e-02 1.391
R-HSA-5579031 Defective ACTH causes obesity and POMCD 4.063678e-02 1.391
R-HSA-9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 4.063678e-02 1.391
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 4.063678e-02 1.391
R-HSA-389948 Co-inhibition by PD-1 4.112436e-02 1.386
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 5.156278e-02 1.288
R-HSA-6802957 Oncogenic MAPK signaling 4.596830e-02 1.338
R-HSA-209543 p75NTR recruits signalling complexes 4.419525e-02 1.355
R-HSA-170968 Frs2-mediated activation 4.923034e-02 1.308
R-HSA-399719 Trafficking of AMPA receptors 4.266135e-02 1.370
R-HSA-5693537 Resolution of D-Loop Structures 5.156278e-02 1.288
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 4.850282e-02 1.314
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 4.266135e-02 1.370
R-HSA-9764561 Regulation of CDH1 Function 4.770200e-02 1.321
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 4.923034e-02 1.308
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 4.553531e-02 1.342
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 4.850282e-02 1.314
R-HSA-9022692 Regulation of MECP2 expression and activity 4.850282e-02 1.314
R-HSA-180534 Vpu mediated degradation of CD4 5.156278e-02 1.288
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.771462e-02 1.321
R-HSA-163359 Glucagon signaling in metabolic regulation 5.156278e-02 1.288
R-HSA-913531 Interferon Signaling 4.464659e-02 1.350
R-HSA-194441 Metabolism of non-coding RNA 5.219386e-02 1.282
R-HSA-191859 snRNP Assembly 5.219386e-02 1.282
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 5.219386e-02 1.282
R-HSA-9645723 Diseases of programmed cell death 5.318683e-02 1.274
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 5.471403e-02 1.262
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 5.471403e-02 1.262
R-HSA-168325 Viral Messenger RNA Synthesis 5.690845e-02 1.245
R-HSA-9793380 Formation of paraxial mesoderm 5.690845e-02 1.245
R-HSA-202424 Downstream TCR signaling 5.702958e-02 1.244
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 5.795533e-02 1.237
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 5.795533e-02 1.237
R-HSA-169911 Regulation of Apoptosis 5.795533e-02 1.237
R-HSA-8986944 Transcriptional Regulation by MECP2 5.900933e-02 1.229
R-HSA-6784531 tRNA processing in the nucleus 5.934874e-02 1.227
R-HSA-193639 p75NTR signals via NF-kB 5.987870e-02 1.223
R-HSA-196780 Biotin transport and metabolism 5.987870e-02 1.223
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 5.987870e-02 1.223
R-HSA-5673001 RAF/MAP kinase cascade 6.005228e-02 1.221
R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... 6.033347e-02 1.219
R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 6.033347e-02 1.219
R-HSA-3359485 Defective CD320 causes MMATC 6.033347e-02 1.219
R-HSA-9636667 Manipulation of host energy metabolism 6.033347e-02 1.219
R-HSA-180585 Vif-mediated degradation of APOBEC3G 6.128537e-02 1.213
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 6.128537e-02 1.213
R-HSA-163560 Triglyceride catabolism 6.128537e-02 1.213
R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 7.962696e-02 1.099
R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 7.962696e-02 1.099
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 6.470280e-02 1.189
R-HSA-8957275 Post-translational protein phosphorylation 7.856614e-02 1.105
R-HSA-5674135 MAP2K and MAPK activation 8.304943e-02 1.081
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.468001e-02 1.189
R-HSA-5685942 HDR through Homologous Recombination (HRR) 7.236811e-02 1.140
R-HSA-169893 Prolonged ERK activation events 6.547207e-02 1.184
R-HSA-399997 Acetylcholine regulates insulin secretion 7.123215e-02 1.147
R-HSA-162587 HIV Life Cycle 7.466473e-02 1.127
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 6.965634e-02 1.157
R-HSA-5675221 Negative regulation of MAPK pathway 8.304943e-02 1.081
R-HSA-9932298 Degradation of CRY and PER proteins 8.304943e-02 1.081
R-HSA-5684996 MAPK1/MAPK3 signaling 6.795536e-02 1.168
R-HSA-4641258 Degradation of DVL 6.470280e-02 1.189
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 7.179410e-02 1.144
R-HSA-4641257 Degradation of AXIN 6.470280e-02 1.189
R-HSA-3214841 PKMTs methylate histone lysines 7.921729e-02 1.101
R-HSA-422356 Regulation of insulin secretion 7.856614e-02 1.105
R-HSA-68875 Mitotic Prophase 6.252855e-02 1.204
R-HSA-388841 Regulation of T cell activation by CD28 family 6.459220e-02 1.190
R-HSA-9604323 Negative regulation of NOTCH4 signaling 7.546498e-02 1.122
R-HSA-5362768 Hh mutants are degraded by ERAD 7.921729e-02 1.101
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 7.179410e-02 1.144
R-HSA-8941858 Regulation of RUNX3 expression and activity 7.546498e-02 1.122
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 7.921729e-02 1.101
R-HSA-69202 Cyclin E associated events during G1/S transition 8.082055e-02 1.092
R-HSA-201556 Signaling by ALK 7.179410e-02 1.144
R-HSA-69541 Stabilization of p53 7.179410e-02 1.144
R-HSA-9613829 Chaperone Mediated Autophagy 8.321618e-02 1.080
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 8.321618e-02 1.080
R-HSA-9831926 Nephron development 8.321618e-02 1.080
R-HSA-5632684 Hedgehog 'on' state 8.374217e-02 1.077
R-HSA-9020702 Interleukin-1 signaling 8.577106e-02 1.067
R-HSA-5578749 Transcriptional regulation by small RNAs 8.671501e-02 1.062
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 8.671501e-02 1.062
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 8.671501e-02 1.062
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 8.695977e-02 1.061
R-HSA-76002 Platelet activation, signaling and aggregation 8.890344e-02 1.051
R-HSA-9709603 Impaired BRCA2 binding to PALB2 8.942271e-02 1.049
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 8.942271e-02 1.049
R-HSA-2243919 Crosslinking of collagen fibrils 8.942271e-02 1.049
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 8.973853e-02 1.047
R-HSA-9909396 Circadian clock 9.017053e-02 1.045
R-HSA-5387390 Hh mutants abrogate ligand secretion 9.094663e-02 1.041
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 9.852547e-02 1.006
R-HSA-9706374 FLT3 signaling through SRC family kinases 1.170371e-01 0.932
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 1.170371e-01 0.932
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 1.351696e-01 0.869
R-HSA-9927353 Co-inhibition by BTLA 1.351696e-01 0.869
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 1.351696e-01 0.869
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 1.351696e-01 0.869
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 1.351696e-01 0.869
R-HSA-9706377 FLT3 signaling by CBL mutants 1.351696e-01 0.869
R-HSA-164525 Plus-strand DNA synthesis 1.529309e-01 0.816
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.529309e-01 0.816
R-HSA-9645135 STAT5 Activation 1.703285e-01 0.769
R-HSA-162585 Uncoating of the HIV Virion 1.703285e-01 0.769
R-HSA-9732724 IFNG signaling activates MAPKs 1.873699e-01 0.727
R-HSA-8932506 DAG1 core M1 glycosylations 1.873699e-01 0.727
R-HSA-2470946 Cohesin Loading onto Chromatin 1.873699e-01 0.727
R-HSA-114516 Disinhibition of SNARE formation 1.873699e-01 0.727
R-HSA-162589 Reverse Transcription of HIV RNA 2.040622e-01 0.690
R-HSA-164516 Minus-strand DNA synthesis 2.040622e-01 0.690
R-HSA-8932504 DAG1 core M2 glycosylations 2.040622e-01 0.690
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 2.204126e-01 0.657
R-HSA-9613354 Lipophagy 2.204126e-01 0.657
R-HSA-9700645 ALK mutants bind TKIs 2.204126e-01 0.657
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 9.576113e-02 1.019
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 9.576113e-02 1.019
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 9.576113e-02 1.019
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 9.576113e-02 1.019
R-HSA-173107 Binding and entry of HIV virion 2.364282e-01 0.626
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 2.364282e-01 0.626
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 2.364282e-01 0.626
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.088019e-01 0.963
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.088019e-01 0.963
R-HSA-8932505 DAG1 core M3 glycosylations 2.521157e-01 0.598
R-HSA-9706019 RHOBTB3 ATPase cycle 2.521157e-01 0.598
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 2.674818e-01 0.573
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 2.674818e-01 0.573
R-HSA-5358493 Synthesis of diphthamide-EEF2 2.674818e-01 0.573
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 2.674818e-01 0.573
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 1.361324e-01 0.866
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 2.825332e-01 0.549
R-HSA-937039 IRAK1 recruits IKK complex 2.825332e-01 0.549
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 2.825332e-01 0.549
R-HSA-445095 Interaction between L1 and Ankyrins 1.503126e-01 0.823
R-HSA-9709570 Impaired BRCA2 binding to RAD51 1.647694e-01 0.783
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 2.093583e-01 0.679
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 2.093583e-01 0.679
R-HSA-72649 Translation initiation complex formation 1.393538e-01 0.856
R-HSA-72702 Ribosomal scanning and start codon recognition 1.489424e-01 0.827
R-HSA-212300 PRC2 methylates histones and DNA 2.244960e-01 0.649
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.687225e-01 0.773
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.015356e-01 0.696
R-HSA-9759194 Nuclear events mediated by NFE2L2 1.515504e-01 0.819
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 1.191315e-01 0.924
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 1.720871e-01 0.764
R-HSA-9762292 Regulation of CDH11 function 2.364282e-01 0.626
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 2.521157e-01 0.598
R-HSA-3371568 Attenuation phase 2.549759e-01 0.594
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 2.093583e-01 0.679
R-HSA-5576890 Phase 3 - rapid repolarisation 1.873699e-01 0.727
R-HSA-2465910 MASTL Facilitates Mitotic Progression 2.204126e-01 0.657
R-HSA-8951936 RUNX3 regulates p14-ARF 2.825332e-01 0.549
R-HSA-774815 Nucleosome assembly 9.914315e-02 1.004
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 9.914315e-02 1.004
R-HSA-3371571 HSF1-dependent transactivation 1.253886e-01 0.902
R-HSA-162594 Early Phase of HIV Life Cycle 1.022234e-01 0.990
R-HSA-9907900 Proteasome assembly 9.500833e-02 1.022
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 2.825332e-01 0.549
R-HSA-5334118 DNA methylation 1.647694e-01 0.783
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 2.169153e-01 0.664
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.264244e-01 0.645
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 2.397123e-01 0.620
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 1.351696e-01 0.869
R-HSA-8849473 PTK6 Expression 1.873699e-01 0.727
R-HSA-164843 2-LTR circle formation 2.364282e-01 0.626
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 2.674818e-01 0.573
R-HSA-73762 RNA Polymerase I Transcription Initiation 2.778977e-01 0.556
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 2.778977e-01 0.556
R-HSA-1980145 Signaling by NOTCH2 2.093583e-01 0.679
R-HSA-165159 MTOR signalling 2.778977e-01 0.556
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.665895e-01 0.574
R-HSA-9930044 Nuclear RNA decay 1.943332e-01 0.711
R-HSA-5693538 Homology Directed Repair 1.419904e-01 0.848
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 2.204126e-01 0.657
R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.614913e-01 0.583
R-HSA-1980143 Signaling by NOTCH1 9.910747e-02 1.004
R-HSA-1614603 Cysteine formation from homocysteine 1.873699e-01 0.727
R-HSA-446107 Type I hemidesmosome assembly 2.040622e-01 0.690
R-HSA-9768778 Regulation of NPAS4 mRNA translation 2.040622e-01 0.690
R-HSA-451306 Ionotropic activity of kainate receptors 2.521157e-01 0.598
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.291612e-01 0.889
R-HSA-209560 NF-kB is activated and signals survival 2.674818e-01 0.573
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 2.825332e-01 0.549
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 2.825332e-01 0.549
R-HSA-380615 Serotonin clearance from the synaptic cleft 2.825332e-01 0.549
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 2.825332e-01 0.549
R-HSA-5576892 Phase 0 - rapid depolarisation 1.575093e-01 0.803
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 1.033493e-01 0.986
R-HSA-1250196 SHC1 events in ERBB2 signaling 1.720871e-01 0.764
R-HSA-5655302 Signaling by FGFR1 in disease 2.702581e-01 0.568
R-HSA-9948299 Ribosome-associated quality control 2.213693e-01 0.655
R-HSA-187687 Signalling to ERKs 2.169153e-01 0.664
R-HSA-447043 Neurofascin interactions 1.703285e-01 0.769
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 2.102905e-01 0.677
R-HSA-390648 Muscarinic acetylcholine receptors 1.351696e-01 0.869
R-HSA-1253288 Downregulation of ERBB4 signaling 2.040622e-01 0.690
R-HSA-448706 Interleukin-1 processing 2.204126e-01 0.657
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 2.204126e-01 0.657
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 1.154892e-01 0.937
R-HSA-3000171 Non-integrin membrane-ECM interactions 2.482825e-01 0.605
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 1.431849e-01 0.844
R-HSA-1236974 ER-Phagosome pathway 1.482757e-01 0.829
R-HSA-5654732 Negative regulation of FGFR3 signaling 1.575093e-01 0.803
R-HSA-5654733 Negative regulation of FGFR4 signaling 1.647694e-01 0.783
R-HSA-5654727 Negative regulation of FGFR2 signaling 2.093583e-01 0.679
R-HSA-73933 Resolution of Abasic Sites (AP sites) 2.626164e-01 0.581
R-HSA-9960525 CASP5-mediated substrate cleavage 9.852547e-02 1.006
R-HSA-8981373 Intestinal hexose absorption 1.529309e-01 0.816
R-HSA-187706 Signalling to p38 via RIT and RIN 1.529309e-01 0.816
R-HSA-8857538 PTK6 promotes HIF1A stabilization 1.703285e-01 0.769
R-HSA-170984 ARMS-mediated activation 2.204126e-01 0.657
R-HSA-2025928 Calcineurin activates NFAT 2.204126e-01 0.657
R-HSA-2179392 EGFR Transactivation by Gastrin 2.364282e-01 0.626
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 9.914315e-02 1.004
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.033493e-01 0.986
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.076251e-01 0.968
R-HSA-5654726 Negative regulation of FGFR1 signaling 1.943332e-01 0.711
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.299855e-01 0.886
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 1.346412e-01 0.871
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 2.093583e-01 0.679
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 1.587369e-01 0.799
R-HSA-69239 Synthesis of DNA 2.352352e-01 0.628
R-HSA-212165 Epigenetic regulation of gene expression 1.791479e-01 0.747
R-HSA-199992 trans-Golgi Network Vesicle Budding 2.318551e-01 0.635
R-HSA-5607764 CLEC7A (Dectin-1) signaling 1.839465e-01 0.735
R-HSA-5653656 Vesicle-mediated transport 9.813460e-02 1.008
R-HSA-9634597 GPER1 signaling 1.119688e-01 0.951
R-HSA-69242 S Phase 1.339141e-01 0.873
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.532225e-01 0.815
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 2.169153e-01 0.664
R-HSA-3000178 ECM proteoglycans 2.264244e-01 0.645
R-HSA-392499 Metabolism of proteins 2.619939e-01 0.582
R-HSA-162599 Late Phase of HIV Life Cycle 1.183539e-01 0.927
R-HSA-9960519 CASP4-mediated substrate cleavage 9.852547e-02 1.006
R-HSA-9707587 Regulation of HMOX1 expression and activity 1.170371e-01 0.932
R-HSA-447038 NrCAM interactions 1.351696e-01 0.869
R-HSA-427652 Sodium-coupled phosphate cotransporters 1.529309e-01 0.816
R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 1.529309e-01 0.816
R-HSA-199920 CREB phosphorylation 1.703285e-01 0.769
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 1.873699e-01 0.727
R-HSA-426117 Cation-coupled Chloride cotransporters 1.873699e-01 0.727
R-HSA-201688 WNT mediated activation of DVL 2.204126e-01 0.657
R-HSA-2514853 Condensation of Prometaphase Chromosomes 2.674818e-01 0.573
R-HSA-69091 Polymerase switching 2.825332e-01 0.549
R-HSA-69109 Leading Strand Synthesis 2.825332e-01 0.549
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 2.825332e-01 0.549
R-HSA-68949 Orc1 removal from chromatin 1.299855e-01 0.886
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 1.393538e-01 0.856
R-HSA-597592 Post-translational protein modification 1.556704e-01 0.808
R-HSA-1236975 Antigen processing-Cross presentation 2.396607e-01 0.620
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.624719e-01 0.789
R-HSA-430116 GP1b-IX-V activation signalling 2.204126e-01 0.657
R-HSA-9758890 Transport of RCbl within the body 2.521157e-01 0.598
R-HSA-202403 TCR signaling 1.121669e-01 0.950
R-HSA-9764265 Regulation of CDH1 Expression and Function 1.075924e-01 0.968
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 1.075924e-01 0.968
R-HSA-418990 Adherens junctions interactions 2.274380e-01 0.643
R-HSA-446728 Cell junction organization 1.701341e-01 0.769
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.529309e-01 0.816
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 1.529309e-01 0.816
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.529309e-01 0.816
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.529309e-01 0.816
R-HSA-447041 CHL1 interactions 1.873699e-01 0.727
R-HSA-5336415 Uptake and function of diphtheria toxin 1.873699e-01 0.727
R-HSA-209952 Peptide hormone biosynthesis 2.364282e-01 0.626
R-HSA-9005895 Pervasive developmental disorders 2.825332e-01 0.549
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 2.825332e-01 0.549
R-HSA-9697154 Disorders of Nervous System Development 2.825332e-01 0.549
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 9.914315e-02 1.004
R-HSA-5658442 Regulation of RAS by GAPs 1.208523e-01 0.918
R-HSA-69052 Switching of origins to a post-replicative state 2.373094e-01 0.625
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 1.448002e-01 0.839
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 2.244960e-01 0.649
R-HSA-70221 Glycogen breakdown (glycogenolysis) 1.361324e-01 0.866
R-HSA-1500931 Cell-Cell communication 2.654709e-01 0.576
R-HSA-5689603 UCH proteinases 2.537982e-01 0.596
R-HSA-8963676 Intestinal absorption 2.040622e-01 0.690
R-HSA-3323169 Defects in biotin (Btn) metabolism 2.204126e-01 0.657
R-HSA-9671555 Signaling by PDGFR in disease 1.088019e-01 0.963
R-HSA-9748787 Azathioprine ADME 1.208523e-01 0.918
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.346412e-01 0.871
R-HSA-8878171 Transcriptional regulation by RUNX1 1.426914e-01 0.846
R-HSA-3858494 Beta-catenin independent WNT signaling 2.139732e-01 0.670
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 2.364282e-01 0.626
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.441215e-01 0.841
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.370397e-01 0.863
R-HSA-9659379 Sensory processing of sound 2.704437e-01 0.568
R-HSA-453276 Regulation of mitotic cell cycle 2.264244e-01 0.645
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.264244e-01 0.645
R-HSA-1474244 Extracellular matrix organization 1.969410e-01 0.706
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 2.204126e-01 0.657
R-HSA-8934903 Receptor Mediated Mitophagy 2.364282e-01 0.626
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.154892e-01 0.937
R-HSA-210990 PECAM1 interactions 2.521157e-01 0.598
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 9.500833e-02 1.022
R-HSA-4608870 Asymmetric localization of PCP proteins 9.914315e-02 1.004
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.102905e-01 0.677
R-HSA-1483249 Inositol phosphate metabolism 1.178684e-01 0.929
R-HSA-446203 Asparagine N-linked glycosylation 1.353263e-01 0.869
R-HSA-3000170 Syndecan interactions 1.222779e-01 0.913
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.489424e-01 0.827
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 1.892097e-01 0.723
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 2.825332e-01 0.549
R-HSA-5678895 Defective CFTR causes cystic fibrosis 9.914315e-02 1.004
R-HSA-6807070 PTEN Regulation 1.085141e-01 0.965
R-HSA-6794362 Protein-protein interactions at synapses 1.297498e-01 0.887
R-HSA-445717 Aquaporin-mediated transport 1.737825e-01 0.760
R-HSA-168255 Influenza Infection 2.308883e-01 0.637
R-HSA-9824446 Viral Infection Pathways 1.589966e-01 0.799
R-HSA-201681 TCF dependent signaling in response to WNT 2.443508e-01 0.612
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 9.914315e-02 1.004
R-HSA-168638 NOD1/2 Signaling Pathway 2.093583e-01 0.679
R-HSA-8939902 Regulation of RUNX2 expression and activity 1.737825e-01 0.760
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 2.040622e-01 0.690
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 2.204126e-01 0.657
R-HSA-3296482 Defects in vitamin and cofactor metabolism 2.169153e-01 0.664
R-HSA-5689880 Ub-specific processing proteases 2.111649e-01 0.675
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 2.760200e-01 0.559
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.397123e-01 0.620
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.291612e-01 0.889
R-HSA-8863678 Neurodegenerative Diseases 1.291612e-01 0.889
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 9.914315e-02 1.004
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 9.914315e-02 1.004
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 1.226277e-01 0.911
R-HSA-8953750 Transcriptional Regulation by E2F6 2.473400e-01 0.607
R-HSA-1257604 PIP3 activates AKT signaling 1.233914e-01 0.909
R-HSA-9755088 Ribavirin ADME 1.088019e-01 0.963
R-HSA-4086400 PCP/CE pathway 1.055960e-01 0.976
R-HSA-8979227 Triglyceride metabolism 1.637067e-01 0.786
R-HSA-8982491 Glycogen metabolism 2.549759e-01 0.594
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.327047e-01 0.877
R-HSA-9008059 Interleukin-37 signaling 1.720871e-01 0.764
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 1.788849e-01 0.747
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 1.840278e-01 0.735
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 1.266722e-01 0.897
R-HSA-9700206 Signaling by ALK in cancer 2.352352e-01 0.628
R-HSA-194138 Signaling by VEGF 1.680608e-01 0.775
R-HSA-5358346 Hedgehog ligand biogenesis 1.253886e-01 0.902
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 2.401871e-01 0.619
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.352352e-01 0.628
R-HSA-1169408 ISG15 antiviral mechanism 9.593536e-02 1.018
R-HSA-9692914 SARS-CoV-1-host interactions 2.308299e-01 0.637
R-HSA-69615 G1/S DNA Damage Checkpoints 1.840278e-01 0.735
R-HSA-9705683 SARS-CoV-2-host interactions 2.581397e-01 0.588
R-HSA-1566948 Elastic fibre formation 2.397123e-01 0.620
R-HSA-351202 Metabolism of polyamines 1.687225e-01 0.773
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 2.702581e-01 0.568
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 2.704437e-01 0.568
R-HSA-9824272 Somitogenesis 9.914315e-02 1.004
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.868741e-01 0.728
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2.778977e-01 0.556
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 1.163784e-01 0.934
R-HSA-69563 p53-Dependent G1 DNA Damage Response 1.163784e-01 0.934
R-HSA-195253 Degradation of beta-catenin by the destruction complex 2.210190e-01 0.656
R-HSA-5619084 ABC transporter disorders 2.648803e-01 0.577
R-HSA-5357801 Programmed Cell Death 9.948249e-02 1.002
R-HSA-109581 Apoptosis 1.736880e-01 0.760
R-HSA-5619115 Disorders of transmembrane transporters 1.936943e-01 0.713
R-HSA-211000 Gene Silencing by RNA 2.352352e-01 0.628
R-HSA-69306 DNA Replication 2.829557e-01 0.548
R-HSA-5654743 Signaling by FGFR4 2.855321e-01 0.544
R-HSA-9710421 Defective pyroptosis 2.855321e-01 0.544
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 2.920799e-01 0.534
R-HSA-157118 Signaling by NOTCH 2.964318e-01 0.528
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 2.972762e-01 0.527
R-HSA-5654741 Signaling by FGFR3 3.007735e-01 0.522
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 3.028718e-01 0.519
R-HSA-73886 Chromosome Maintenance 3.078957e-01 0.512
R-HSA-9675135 Diseases of DNA repair 3.083748e-01 0.511
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 3.083748e-01 0.511
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 3.083748e-01 0.511
R-HSA-75153 Apoptotic execution phase 3.083748e-01 0.511
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 3.096708e-01 0.509
R-HSA-9679506 SARS-CoV Infections 3.108460e-01 0.507
R-HSA-5633007 Regulation of TP53 Activity 3.108999e-01 0.507
R-HSA-69166 Removal of the Flap Intermediate 3.117171e-01 0.506
R-HSA-5655291 Signaling by FGFR4 in disease 3.117171e-01 0.506
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 3.117171e-01 0.506
R-HSA-6814848 Glycerophospholipid catabolism 3.117171e-01 0.506
R-HSA-1433559 Regulation of KIT signaling 3.117171e-01 0.506
R-HSA-9686114 Non-canonical inflammasome activation 3.117171e-01 0.506
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 3.159597e-01 0.500
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.159597e-01 0.500
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.171740e-01 0.499
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.235256e-01 0.490
R-HSA-70263 Gluconeogenesis 3.235256e-01 0.490
R-HSA-69183 Processive synthesis on the lagging strand 3.258622e-01 0.487
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 3.258622e-01 0.487
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 3.258622e-01 0.487
R-HSA-1295596 Spry regulation of FGF signaling 3.258622e-01 0.487
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 3.258622e-01 0.487
R-HSA-8876725 Protein methylation 3.258622e-01 0.487
R-HSA-446353 Cell-extracellular matrix interactions 3.258622e-01 0.487
R-HSA-156902 Peptide chain elongation 3.265598e-01 0.486
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.310701e-01 0.480
R-HSA-73893 DNA Damage Bypass 3.310701e-01 0.480
R-HSA-69206 G1/S Transition 3.311324e-01 0.480
R-HSA-421270 Cell-cell junction organization 3.325450e-01 0.478
R-HSA-109704 PI3K Cascade 3.385909e-01 0.470
R-HSA-5619102 SLC transporter disorders 3.392020e-01 0.470
R-HSA-9706369 Negative regulation of FLT3 3.397174e-01 0.469
R-HSA-5083625 Defective GALNT3 causes HFTC 3.397174e-01 0.469
R-HSA-5083636 Defective GALNT12 causes CRCS1 3.397174e-01 0.469
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 3.397174e-01 0.469
R-HSA-5099900 WNT5A-dependent internalization of FZD4 3.397174e-01 0.469
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 3.397174e-01 0.469
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 3.397174e-01 0.469
R-HSA-69481 G2/M Checkpoints 3.404569e-01 0.468
R-HSA-195721 Signaling by WNT 3.406966e-01 0.468
R-HSA-74160 Gene expression (Transcription) 3.491061e-01 0.457
R-HSA-397014 Muscle contraction 3.508525e-01 0.455
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 3.532887e-01 0.452
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 3.532887e-01 0.452
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 3.532887e-01 0.452
R-HSA-5576893 Phase 2 - plateau phase 3.532887e-01 0.452
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 3.532887e-01 0.452
R-HSA-9675151 Disorders of Developmental Biology 3.532887e-01 0.452
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 3.532887e-01 0.452
R-HSA-112382 Formation of RNA Pol II elongation complex 3.535527e-01 0.452
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.535527e-01 0.452
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.535527e-01 0.452
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.544577e-01 0.450
R-HSA-156842 Eukaryotic Translation Elongation 3.546859e-01 0.450
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 3.546859e-01 0.450
R-HSA-72306 tRNA processing 3.554705e-01 0.449
R-HSA-418555 G alpha (s) signalling events 3.595437e-01 0.444
R-HSA-68867 Assembly of the pre-replicative complex 3.602975e-01 0.443
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.609896e-01 0.443
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.609896e-01 0.443
R-HSA-75955 RNA Polymerase II Transcription Elongation 3.609896e-01 0.443
R-HSA-445355 Smooth Muscle Contraction 3.609896e-01 0.443
R-HSA-5576891 Cardiac conduction 3.637929e-01 0.439
R-HSA-1643685 Disease 3.655147e-01 0.437
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 3.659019e-01 0.437
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 3.665818e-01 0.436
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 3.665818e-01 0.436
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 3.665818e-01 0.436
R-HSA-2028269 Signaling by Hippo 3.665818e-01 0.436
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 3.665818e-01 0.436
R-HSA-9768759 Regulation of NPAS4 gene expression 3.665818e-01 0.436
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 3.683946e-01 0.434
R-HSA-168249 Innate Immune System 3.741706e-01 0.427
R-HSA-9012852 Signaling by NOTCH3 3.757659e-01 0.425
R-HSA-72689 Formation of a pool of free 40S subunits 3.770852e-01 0.424
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 3.770852e-01 0.424
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 3.796026e-01 0.421
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 3.796026e-01 0.421
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 3.796026e-01 0.421
R-HSA-156711 Polo-like kinase mediated events 3.796026e-01 0.421
R-HSA-4419969 Depolymerization of the Nuclear Lamina 3.796026e-01 0.421
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 3.796026e-01 0.421
R-HSA-111471 Apoptotic factor-mediated response 3.796026e-01 0.421
R-HSA-5358508 Mismatch Repair 3.796026e-01 0.421
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 3.831016e-01 0.417
R-HSA-5654736 Signaling by FGFR1 3.831016e-01 0.417
R-HSA-5578775 Ion homeostasis 3.831016e-01 0.417
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 3.831016e-01 0.417
R-HSA-9711123 Cellular response to chemical stress 3.894052e-01 0.410
R-HSA-112399 IRS-mediated signalling 3.904003e-01 0.408
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 3.904003e-01 0.408
R-HSA-73894 DNA Repair 3.907481e-01 0.408
R-HSA-5654710 PI-3K cascade:FGFR3 3.923564e-01 0.406
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 3.923564e-01 0.406
R-HSA-844456 The NLRP3 inflammasome 3.923564e-01 0.406
R-HSA-449836 Other interleukin signaling 3.923564e-01 0.406
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 3.923564e-01 0.406
R-HSA-975871 MyD88 cascade initiated on plasma membrane 3.937814e-01 0.405
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 3.937814e-01 0.405
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 3.937814e-01 0.405
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 3.976602e-01 0.400
R-HSA-193704 p75 NTR receptor-mediated signalling 3.993220e-01 0.399
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 4.008188e-01 0.397
R-HSA-382556 ABC-family proteins mediated transport 4.048487e-01 0.393
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 4.048488e-01 0.393
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 4.048488e-01 0.393
R-HSA-5654720 PI-3K cascade:FGFR4 4.048488e-01 0.393
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 4.048488e-01 0.393
R-HSA-140875 Common Pathway of Fibrin Clot Formation 4.048488e-01 0.393
R-HSA-71288 Creatine metabolism 4.048488e-01 0.393
R-HSA-445144 Signal transduction by L1 4.048488e-01 0.393
R-HSA-373753 Nephrin family interactions 4.048488e-01 0.393
R-HSA-429914 Deadenylation-dependent mRNA decay 4.048800e-01 0.393
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 4.120582e-01 0.385
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 4.120582e-01 0.385
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 4.120582e-01 0.385
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 4.120582e-01 0.385
R-HSA-2644603 Signaling by NOTCH1 in Cancer 4.120582e-01 0.385
R-HSA-8943724 Regulation of PTEN gene transcription 4.120582e-01 0.385
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.120582e-01 0.385
R-HSA-1227986 Signaling by ERBB2 4.120582e-01 0.385
R-HSA-8953854 Metabolism of RNA 4.141507e-01 0.383
R-HSA-9842860 Regulation of endogenous retroelements 4.158569e-01 0.381
R-HSA-1483255 PI Metabolism 4.158569e-01 0.381
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 4.170852e-01 0.380
R-HSA-9939291 Matriglycan biosynthesis on DAG1 4.170852e-01 0.380
R-HSA-202040 G-protein activation 4.170852e-01 0.380
R-HSA-69186 Lagging Strand Synthesis 4.170852e-01 0.380
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 4.170852e-01 0.380
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 4.170852e-01 0.380
R-HSA-5357786 TNFR1-induced proapoptotic signaling 4.170852e-01 0.380
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 4.170852e-01 0.380
R-HSA-198753 ERK/MAPK targets 4.170852e-01 0.380
R-HSA-210991 Basigin interactions 4.170852e-01 0.380
R-HSA-450294 MAP kinase activation 4.191934e-01 0.378
R-HSA-2428928 IRS-related events triggered by IGF1R 4.191934e-01 0.378
R-HSA-5663205 Infectious disease 4.213767e-01 0.375
R-HSA-72312 rRNA processing 4.240879e-01 0.373
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.262845e-01 0.370
R-HSA-9707616 Heme signaling 4.262845e-01 0.370
R-HSA-186797 Signaling by PDGF 4.262845e-01 0.370
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.262845e-01 0.370
R-HSA-9860931 Response of endothelial cells to shear stress 4.267993e-01 0.370
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 4.290707e-01 0.367
R-HSA-5654706 FRS-mediated FGFR3 signaling 4.290707e-01 0.367
R-HSA-193048 Androgen biosynthesis 4.290707e-01 0.367
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 4.290707e-01 0.367
R-HSA-8876384 Listeria monocytogenes entry into host cells 4.290707e-01 0.367
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 4.290707e-01 0.367
R-HSA-194002 Glucocorticoid biosynthesis 4.290707e-01 0.367
R-HSA-175474 Assembly Of The HIV Virion 4.290707e-01 0.367
R-HSA-2871837 FCERI mediated NF-kB activation 4.333035e-01 0.363
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 4.376694e-01 0.359
R-HSA-936837 Ion transport by P-type ATPases 4.403293e-01 0.356
R-HSA-2428924 IGF1R signaling cascade 4.403293e-01 0.356
R-HSA-74751 Insulin receptor signalling cascade 4.403293e-01 0.356
R-HSA-5654689 PI-3K cascade:FGFR1 4.408105e-01 0.356
R-HSA-5654712 FRS-mediated FGFR4 signaling 4.408105e-01 0.356
R-HSA-350054 Notch-HLH transcription pathway 4.408105e-01 0.356
R-HSA-166208 mTORC1-mediated signalling 4.408105e-01 0.356
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 4.408105e-01 0.356
R-HSA-453279 Mitotic G1 phase and G1/S transition 4.424418e-01 0.354
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 4.437721e-01 0.353
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.472809e-01 0.349
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 4.472809e-01 0.349
R-HSA-977068 Termination of O-glycan biosynthesis 4.523096e-01 0.345
R-HSA-8854691 Interleukin-20 family signaling 4.523096e-01 0.345
R-HSA-912526 Interleukin receptor SHC signaling 4.523096e-01 0.345
R-HSA-200425 Carnitine shuttle 4.523096e-01 0.345
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 4.538262e-01 0.343
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.538262e-01 0.343
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 4.538262e-01 0.343
R-HSA-9758941 Gastrulation 4.560657e-01 0.341
R-HSA-72766 Translation 4.570802e-01 0.340
R-HSA-975155 MyD88 dependent cascade initiated on endosome 4.591694e-01 0.338
R-HSA-69002 DNA Replication Pre-Initiation 4.591694e-01 0.338
R-HSA-9679191 Potential therapeutics for SARS 4.605828e-01 0.337
R-HSA-983169 Class I MHC mediated antigen processing & presentation 4.609430e-01 0.336
R-HSA-9830369 Kidney development 4.610374e-01 0.336
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 4.635729e-01 0.334
R-HSA-933542 TRAF6 mediated NF-kB activation 4.635729e-01 0.334
R-HSA-429947 Deadenylation of mRNA 4.635729e-01 0.334
R-HSA-5669034 TNFs bind their physiological receptors 4.635729e-01 0.334
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 4.644903e-01 0.333
R-HSA-166166 MyD88-independent TLR4 cascade 4.644903e-01 0.333
R-HSA-5218859 Regulated Necrosis 4.678406e-01 0.330
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 4.745924e-01 0.324
R-HSA-5654695 PI-3K cascade:FGFR2 4.746053e-01 0.324
R-HSA-5654693 FRS-mediated FGFR1 signaling 4.746053e-01 0.324
R-HSA-9620244 Long-term potentiation 4.746053e-01 0.324
R-HSA-5218921 VEGFR2 mediated cell proliferation 4.746053e-01 0.324
R-HSA-9932444 ATP-dependent chromatin remodelers 4.746053e-01 0.324
R-HSA-9932451 SWI/SNF chromatin remodelers 4.746053e-01 0.324
R-HSA-174411 Polymerase switching on the C-strand of the telomere 4.746053e-01 0.324
R-HSA-3214842 HDMs demethylate histones 4.746053e-01 0.324
R-HSA-3296469 Defects in cobalamin (B12) metabolism 4.746053e-01 0.324
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.785181e-01 0.320
R-HSA-73887 Death Receptor Signaling 4.785181e-01 0.320
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4.803130e-01 0.318
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.812924e-01 0.318
R-HSA-448424 Interleukin-17 signaling 4.812924e-01 0.318
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 4.854114e-01 0.314
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 4.854114e-01 0.314
R-HSA-3295583 TRP channels 4.854114e-01 0.314
R-HSA-4839726 Chromatin organization 4.854786e-01 0.314
R-HSA-9855142 Cellular responses to mechanical stimuli 4.855386e-01 0.314
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.879396e-01 0.312
R-HSA-427413 NoRC negatively regulates rRNA expression 4.879396e-01 0.312
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 4.879396e-01 0.312
R-HSA-9610379 HCMV Late Events 4.918180e-01 0.308
R-HSA-9924644 Developmental Lineages of the Mammary Gland 4.945334e-01 0.306
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4.959136e-01 0.305
R-HSA-174414 Processive synthesis on the C-strand of the telomere 4.959960e-01 0.305
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 4.959960e-01 0.305
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 4.959960e-01 0.305
R-HSA-73863 RNA Polymerase I Transcription Termination 4.959960e-01 0.305
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 4.959960e-01 0.305
R-HSA-5655332 Signaling by FGFR3 in disease 4.959960e-01 0.305
R-HSA-201451 Signaling by BMP 4.959960e-01 0.305
R-HSA-9006115 Signaling by NTRK2 (TRKB) 4.959960e-01 0.305
R-HSA-9828806 Maturation of hRSV A proteins 4.959960e-01 0.305
R-HSA-9694516 SARS-CoV-2 Infection 4.988332e-01 0.302
R-HSA-4086398 Ca2+ pathway 5.010733e-01 0.300
R-HSA-72737 Cap-dependent Translation Initiation 5.061833e-01 0.296
R-HSA-72613 Eukaryotic Translation Initiation 5.061833e-01 0.296
R-HSA-167287 HIV elongation arrest and recovery 5.063634e-01 0.296
R-HSA-167290 Pausing and recovery of HIV elongation 5.063634e-01 0.296
R-HSA-5654700 FRS-mediated FGFR2 signaling 5.063634e-01 0.296
R-HSA-451326 Activation of kainate receptors upon glutamate binding 5.063634e-01 0.296
R-HSA-622312 Inflammasomes 5.063634e-01 0.296
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 5.063634e-01 0.296
R-HSA-5620971 Pyroptosis 5.063634e-01 0.296
R-HSA-5688426 Deubiquitination 5.066871e-01 0.295
R-HSA-674695 RNA Polymerase II Pre-transcription Events 5.075586e-01 0.295
R-HSA-1226099 Signaling by FGFR in disease 5.075586e-01 0.295
R-HSA-9007101 Rab regulation of trafficking 5.112776e-01 0.291
R-HSA-1266738 Developmental Biology 5.128624e-01 0.290
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 5.139889e-01 0.289
R-HSA-8852135 Protein ubiquitination 5.139889e-01 0.289
R-HSA-2219528 PI3K/AKT Signaling in Cancer 5.163441e-01 0.287
R-HSA-9615710 Late endosomal microautophagy 5.165183e-01 0.287
R-HSA-5654708 Downstream signaling of activated FGFR3 5.165183e-01 0.287
R-HSA-9759475 Regulation of CDH11 Expression and Function 5.165183e-01 0.287
R-HSA-5656169 Termination of translesion DNA synthesis 5.165183e-01 0.287
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 5.165183e-01 0.287
R-HSA-420092 Glucagon-type ligand receptors 5.165183e-01 0.287
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.203636e-01 0.284
R-HSA-9020591 Interleukin-12 signaling 5.203636e-01 0.284
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.213824e-01 0.283
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.213824e-01 0.283
R-HSA-8878166 Transcriptional regulation by RUNX2 5.213824e-01 0.283
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 5.264648e-01 0.279
R-HSA-5654716 Downstream signaling of activated FGFR4 5.264648e-01 0.279
R-HSA-112311 Neurotransmitter clearance 5.264648e-01 0.279
R-HSA-8863795 Downregulation of ERBB2 signaling 5.264648e-01 0.279
R-HSA-1227990 Signaling by ERBB2 in Cancer 5.264648e-01 0.279
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 5.266823e-01 0.278
R-HSA-418594 G alpha (i) signalling events 5.296606e-01 0.276
R-HSA-9730414 MITF-M-regulated melanocyte development 5.307879e-01 0.275
R-HSA-73864 RNA Polymerase I Transcription 5.329447e-01 0.273
R-HSA-6783783 Interleukin-10 signaling 5.329447e-01 0.273
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 5.362073e-01 0.271
R-HSA-162588 Budding and maturation of HIV virion 5.362073e-01 0.271
R-HSA-5694530 Cargo concentration in the ER 5.362073e-01 0.271
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 5.362073e-01 0.271
R-HSA-182971 EGFR downregulation 5.362073e-01 0.271
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.363244e-01 0.271
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.363244e-01 0.271
R-HSA-416476 G alpha (q) signalling events 5.378847e-01 0.269
R-HSA-5654738 Signaling by FGFR2 5.452989e-01 0.263
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 5.452989e-01 0.263
R-HSA-8931838 DAG1 glycosylations 5.457500e-01 0.263
R-HSA-1538133 G0 and Early G1 5.457500e-01 0.263
R-HSA-69190 DNA strand elongation 5.457500e-01 0.263
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 5.550969e-01 0.256
R-HSA-1839124 FGFR1 mutant receptor activation 5.550969e-01 0.256
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 5.550969e-01 0.256
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 5.550969e-01 0.256
R-HSA-5675482 Regulation of necroptotic cell death 5.550969e-01 0.256
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 5.550969e-01 0.256
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 5.550969e-01 0.256
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 5.606286e-01 0.251
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 5.642520e-01 0.249
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 5.642520e-01 0.249
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 5.642520e-01 0.249
R-HSA-5223345 Miscellaneous transport and binding events 5.642520e-01 0.249
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.693178e-01 0.245
R-HSA-187037 Signaling by NTRK1 (TRKA) 5.701330e-01 0.244
R-HSA-9678108 SARS-CoV-1 Infection 5.723803e-01 0.242
R-HSA-9768919 NPAS4 regulates expression of target genes 5.732193e-01 0.242
R-HSA-5696400 Dual Incision in GG-NER 5.732193e-01 0.242
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 5.732193e-01 0.242
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 5.732193e-01 0.242
R-HSA-901042 Calnexin/calreticulin cycle 5.732193e-01 0.242
R-HSA-5205647 Mitophagy 5.732193e-01 0.242
R-HSA-1500620 Meiosis 5.751777e-01 0.240
R-HSA-5654696 Downstream signaling of activated FGFR2 5.820026e-01 0.235
R-HSA-5654687 Downstream signaling of activated FGFR1 5.820026e-01 0.235
R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 5.820026e-01 0.235
R-HSA-381042 PERK regulates gene expression 5.820026e-01 0.235
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.878969e-01 0.231
R-HSA-9682385 FLT3 signaling in disease 5.906057e-01 0.229
R-HSA-432720 Lysosome Vesicle Biogenesis 5.906057e-01 0.229
R-HSA-3371511 HSF1 activation 5.906057e-01 0.229
R-HSA-69205 G1/S-Specific Transcription 5.906057e-01 0.229
R-HSA-447115 Interleukin-12 family signaling 5.924077e-01 0.227
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 5.990322e-01 0.223
R-HSA-419037 NCAM1 interactions 5.990322e-01 0.223
R-HSA-8948216 Collagen chain trimerization 5.990322e-01 0.223
R-HSA-3247509 Chromatin modifying enzymes 6.069341e-01 0.217
R-HSA-5213460 RIPK1-mediated regulated necrosis 6.072858e-01 0.217
R-HSA-73884 Base Excision Repair 6.091124e-01 0.215
R-HSA-112310 Neurotransmitter release cycle 6.091124e-01 0.215
R-HSA-15869 Metabolism of nucleotides 6.138107e-01 0.212
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6.145639e-01 0.211
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 6.153699e-01 0.211
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 6.153699e-01 0.211
R-HSA-9648002 RAS processing 6.153699e-01 0.211
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 6.153699e-01 0.211
R-HSA-375276 Peptide ligand-binding receptors 6.156175e-01 0.211
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.199571e-01 0.208
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 6.232882e-01 0.205
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 6.232882e-01 0.205
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 6.232882e-01 0.205
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 6.232882e-01 0.205
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 6.232882e-01 0.205
R-HSA-167169 HIV Transcription Elongation 6.232882e-01 0.205
R-HSA-71240 Tryptophan catabolism 6.232882e-01 0.205
R-HSA-451927 Interleukin-2 family signaling 6.232882e-01 0.205
R-HSA-74752 Signaling by Insulin receptor 6.252922e-01 0.204
R-HSA-983712 Ion channel transport 6.269288e-01 0.203
R-HSA-9607240 FLT3 Signaling 6.310439e-01 0.200
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 6.310439e-01 0.200
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 6.310439e-01 0.200
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 6.310439e-01 0.200
R-HSA-9694548 Maturation of spike protein 6.310439e-01 0.200
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 6.310439e-01 0.200
R-HSA-5218920 VEGFR2 mediated vascular permeability 6.310439e-01 0.200
R-HSA-9837999 Mitochondrial protein degradation 6.357882e-01 0.197
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 6.386404e-01 0.195
R-HSA-442660 SLC-mediated transport of neurotransmitters 6.386404e-01 0.195
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 6.409494e-01 0.193
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 6.409494e-01 0.193
R-HSA-72764 Eukaryotic Translation Termination 6.460531e-01 0.190
R-HSA-379716 Cytosolic tRNA aminoacylation 6.460810e-01 0.190
R-HSA-1433557 Signaling by SCF-KIT 6.533688e-01 0.185
R-HSA-9637690 Response of Mtb to phagocytosis 6.533688e-01 0.185
R-HSA-5683826 Surfactant metabolism 6.605070e-01 0.180
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 6.605070e-01 0.180
R-HSA-375280 Amine ligand-binding receptors 6.605070e-01 0.180
R-HSA-3214858 RMTs methylate histone arginines 6.605070e-01 0.180
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 6.605070e-01 0.180
R-HSA-5368286 Mitochondrial translation initiation 6.610201e-01 0.180
R-HSA-190236 Signaling by FGFR 6.610201e-01 0.180
R-HSA-9614085 FOXO-mediated transcription 6.658952e-01 0.177
R-HSA-1614558 Degradation of cysteine and homocysteine 6.674986e-01 0.176
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 6.674986e-01 0.176
R-HSA-6783310 Fanconi Anemia Pathway 6.674986e-01 0.176
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.699140e-01 0.174
R-HSA-166520 Signaling by NTRKs 6.699140e-01 0.174
R-HSA-5357905 Regulation of TNFR1 signaling 6.743467e-01 0.171
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 6.743467e-01 0.171
R-HSA-2408557 Selenocysteine synthesis 6.754760e-01 0.170
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.768581e-01 0.170
R-HSA-9856651 MITF-M-dependent gene expression 6.777384e-01 0.169
R-HSA-1483191 Synthesis of PC 6.810541e-01 0.167
R-HSA-192823 Viral mRNA Translation 6.848327e-01 0.164
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 6.894278e-01 0.162
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 6.940586e-01 0.159
R-HSA-5696398 Nucleotide Excision Repair 6.984529e-01 0.156
R-HSA-5655253 Signaling by FGFR2 in disease 7.003612e-01 0.155
R-HSA-912446 Meiotic recombination 7.065343e-01 0.151
R-HSA-2514856 The phototransduction cascade 7.065343e-01 0.151
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 7.072600e-01 0.150
R-HSA-9711097 Cellular response to starvation 7.076637e-01 0.150
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 7.115828e-01 0.148
R-HSA-2672351 Stimuli-sensing channels 7.115828e-01 0.148
R-HSA-212436 Generic Transcription Pathway 7.120627e-01 0.147
R-HSA-73772 RNA Polymerase I Promoter Escape 7.125806e-01 0.147
R-HSA-9634815 Transcriptional Regulation by NPAS4 7.125806e-01 0.147
R-HSA-5339562 Uptake and actions of bacterial toxins 7.125806e-01 0.147
R-HSA-9639288 Amino acids regulate mTORC1 7.185027e-01 0.144
R-HSA-1221632 Meiotic synapsis 7.185027e-01 0.144
R-HSA-8956320 Nucleotide biosynthesis 7.185027e-01 0.144
R-HSA-927802 Nonsense-Mediated Decay (NMD) 7.283430e-01 0.138
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 7.283430e-01 0.138
R-HSA-2408522 Selenoamino acid metabolism 7.286809e-01 0.137
R-HSA-3214815 HDACs deacetylate histones 7.299845e-01 0.137
R-HSA-418597 G alpha (z) signalling events 7.299845e-01 0.137
R-HSA-75893 TNF signaling 7.355490e-01 0.133
R-HSA-193648 NRAGE signals death through JNK 7.355490e-01 0.133
R-HSA-109606 Intrinsic Pathway for Apoptosis 7.355490e-01 0.133
R-HSA-177929 Signaling by EGFR 7.355490e-01 0.133
R-HSA-5621480 Dectin-2 family 7.409993e-01 0.130
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.442724e-01 0.128
R-HSA-6782135 Dual incision in TC-NER 7.463375e-01 0.127
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 7.463375e-01 0.127
R-HSA-9658195 Leishmania infection 7.487796e-01 0.126
R-HSA-9824443 Parasitic Infection Pathways 7.487796e-01 0.126
R-HSA-180786 Extension of Telomeres 7.515660e-01 0.124
R-HSA-186712 Regulation of beta-cell development 7.515660e-01 0.124
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 7.515660e-01 0.124
R-HSA-8873719 RAB geranylgeranylation 7.566870e-01 0.121
R-HSA-1660661 Sphingolipid de novo biosynthesis 7.566870e-01 0.121
R-HSA-379724 tRNA Aminoacylation 7.566870e-01 0.121
R-HSA-9664433 Leishmania parasite growth and survival 7.610568e-01 0.119
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.610568e-01 0.119
R-HSA-73857 RNA Polymerase II Transcription 7.614690e-01 0.118
R-HSA-211976 Endogenous sterols 7.617029e-01 0.118
R-HSA-1442490 Collagen degradation 7.617029e-01 0.118
R-HSA-375165 NCAM signaling for neurite out-growth 7.666156e-01 0.115
R-HSA-388396 GPCR downstream signalling 7.700022e-01 0.114
R-HSA-6790901 rRNA modification in the nucleus and cytosol 7.714273e-01 0.113
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 7.714273e-01 0.113
R-HSA-8848021 Signaling by PTK6 7.714273e-01 0.113
R-HSA-8963743 Digestion and absorption 7.714273e-01 0.113
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.772104e-01 0.109
R-HSA-6782315 tRNA modification in the nucleus and cytosol 7.852771e-01 0.105
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.873374e-01 0.104
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.873374e-01 0.104
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.873374e-01 0.104
R-HSA-196071 Metabolism of steroid hormones 7.897052e-01 0.103
R-HSA-5693606 DNA Double Strand Break Response 7.897052e-01 0.103
R-HSA-3700989 Transcriptional Regulation by TP53 7.910740e-01 0.102
R-HSA-913709 O-linked glycosylation of mucins 7.940422e-01 0.100
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 7.940422e-01 0.100
R-HSA-167172 Transcription of the HIV genome 7.940422e-01 0.100
R-HSA-204005 COPII-mediated vesicle transport 8.024505e-01 0.096
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 8.024505e-01 0.096
R-HSA-75105 Fatty acyl-CoA biosynthesis 8.024505e-01 0.096
R-HSA-1474165 Reproduction 8.063841e-01 0.093
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 8.105166e-01 0.091
R-HSA-168898 Toll-like Receptor Cascades 8.114088e-01 0.091
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 8.144256e-01 0.089
R-HSA-69473 G2/M DNA damage checkpoint 8.182542e-01 0.087
R-HSA-1236394 Signaling by ERBB4 8.182542e-01 0.087
R-HSA-9694635 Translation of Structural Proteins 8.292739e-01 0.081
R-HSA-5173105 O-linked glycosylation 8.294169e-01 0.081
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 8.294169e-01 0.081
R-HSA-5368287 Mitochondrial translation 8.321162e-01 0.080
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 8.327971e-01 0.079
R-HSA-416482 G alpha (12/13) signalling events 8.327971e-01 0.079
R-HSA-216083 Integrin cell surface interactions 8.327971e-01 0.079
R-HSA-9734767 Developmental Cell Lineages 8.392116e-01 0.076
R-HSA-5693607 Processing of DNA double-strand break ends 8.429375e-01 0.074
R-HSA-977225 Amyloid fiber formation 8.429375e-01 0.074
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 8.461795e-01 0.073
R-HSA-9707564 Cytoprotection by HMOX1 8.493548e-01 0.071
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 8.614156e-01 0.065
R-HSA-1614635 Sulfur amino acid metabolism 8.614156e-01 0.065
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 8.614156e-01 0.065
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 8.616995e-01 0.065
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 8.682261e-01 0.061
R-HSA-9748784 Drug ADME 8.717995e-01 0.060
R-HSA-373080 Class B/2 (Secretin family receptors) 8.725134e-01 0.059
R-HSA-1989781 PPARA activates gene expression 8.745350e-01 0.058
R-HSA-372790 Signaling by GPCR 8.747787e-01 0.058
R-HSA-1912408 Pre-NOTCH Transcription and Translation 8.751466e-01 0.058
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 8.785854e-01 0.056
R-HSA-9772573 Late SARS-CoV-2 Infection Events 8.802513e-01 0.055
R-HSA-877300 Interferon gamma signaling 8.825151e-01 0.054
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.919835e-01 0.050
R-HSA-5389840 Mitochondrial translation elongation 8.921209e-01 0.050
R-HSA-1483257 Phospholipid metabolism 8.927843e-01 0.049
R-HSA-157579 Telomere Maintenance 8.943502e-01 0.048
R-HSA-202733 Cell surface interactions at the vascular wall 9.024009e-01 0.045
R-HSA-9009391 Extra-nuclear estrogen signaling 9.028172e-01 0.044
R-HSA-2559580 Oxidative Stress Induced Senescence 9.048261e-01 0.043
R-HSA-9937383 Mitochondrial ribosome-associated quality control 9.067935e-01 0.042
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 9.087204e-01 0.042
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 9.106076e-01 0.041
R-HSA-5619507 Activation of HOX genes during differentiation 9.106076e-01 0.041
R-HSA-9833110 RSV-host interactions 9.106076e-01 0.041
R-HSA-2559583 Cellular Senescence 9.186195e-01 0.037
R-HSA-5419276 Mitochondrial translation termination 9.194756e-01 0.036
R-HSA-3781865 Diseases of glycosylation 9.239482e-01 0.034
R-HSA-1912422 Pre-NOTCH Expression and Processing 9.259341e-01 0.033
R-HSA-8957322 Metabolism of steroids 9.271435e-01 0.033
R-HSA-2980736 Peptide hormone metabolism 9.346662e-01 0.029
R-HSA-72163 mRNA Splicing - Major Pathway 9.358690e-01 0.029
R-HSA-9635486 Infection with Mycobacterium tuberculosis 9.399095e-01 0.027
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 9.423716e-01 0.026
R-HSA-6809371 Formation of the cornified envelope 9.435646e-01 0.025
R-HSA-72172 mRNA Splicing 9.469332e-01 0.024
R-HSA-9843745 Adipogenesis 9.532527e-01 0.021
R-HSA-9717189 Sensory perception of taste 9.532527e-01 0.021
R-HSA-1474228 Degradation of the extracellular matrix 9.542211e-01 0.020
R-HSA-71291 Metabolism of amino acids and derivatives 9.558045e-01 0.020
R-HSA-5668914 Diseases of metabolism 9.562323e-01 0.019
R-HSA-382551 Transport of small molecules 9.573189e-01 0.019
R-HSA-9006931 Signaling by Nuclear Receptors 9.577273e-01 0.019
R-HSA-9018519 Estrogen-dependent gene expression 9.587712e-01 0.018
R-HSA-381119 Unfolded Protein Response (UPR) 9.612818e-01 0.017
R-HSA-8856828 Clathrin-mediated endocytosis 9.651319e-01 0.015
R-HSA-2187338 Visual phototransduction 9.679352e-01 0.014
R-HSA-8939211 ESR-mediated signaling 9.702404e-01 0.013
R-HSA-500792 GPCR ligand binding 9.706042e-01 0.013
R-HSA-9609507 Protein localization 9.717245e-01 0.012
R-HSA-9006936 Signaling by TGFB family members 9.755846e-01 0.011
R-HSA-211897 Cytochrome P450 - arranged by substrate type 9.789190e-01 0.009
R-HSA-196854 Metabolism of vitamins and cofactors 9.866380e-01 0.006
R-HSA-428157 Sphingolipid metabolism 9.898936e-01 0.004
R-HSA-1483206 Glycerophospholipid biosynthesis 9.903098e-01 0.004
R-HSA-6805567 Keratinization 9.910918e-01 0.004
R-HSA-9824439 Bacterial Infection Pathways 9.914887e-01 0.004
R-HSA-425407 SLC-mediated transmembrane transport 9.924377e-01 0.003
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 9.945108e-01 0.002
R-HSA-211945 Phase I - Functionalization of compounds 9.980479e-01 0.001
R-HSA-8978868 Fatty acid metabolism 9.998763e-01 0.000
R-HSA-556833 Metabolism of lipids 9.998927e-01 0.000
R-HSA-211859 Biological oxidations 9.999896e-01 0.000
R-HSA-9709957 Sensory Perception 1.000000e+00 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.907 0.273 2 0.926
GCN2GCN2 0.894 0.036 2 0.844
DSTYKDSTYK 0.893 0.172 2 0.911
CDC7CDC7 0.891 0.033 1 0.872
NEK6NEK6 0.891 0.199 -2 0.914
NDR2NDR2 0.890 0.079 -3 0.840
PRPKPRPK 0.890 -0.073 -1 0.878
TGFBR2TGFBR2 0.889 0.189 -2 0.850
TBK1TBK1 0.889 0.035 1 0.819
CAMK2GCAMK2G 0.888 0.050 2 0.883
ULK2ULK2 0.887 -0.017 2 0.826
RAF1RAF1 0.887 -0.021 1 0.898
MOSMOS 0.886 0.056 1 0.897
NEK7NEK7 0.886 0.097 -3 0.863
CLK3CLK3 0.886 0.156 1 0.846
IKKEIKKE 0.886 0.006 1 0.815
BMPR2BMPR2 0.885 0.096 -2 0.889
PIM3PIM3 0.885 0.038 -3 0.829
PDHK4PDHK4 0.885 -0.196 1 0.903
RIPK3RIPK3 0.884 0.097 3 0.857
PKN3PKN3 0.884 0.064 -3 0.836
CAMK1BCAMK1B 0.884 -0.008 -3 0.874
PRKD1PRKD1 0.883 0.061 -3 0.818
IKKBIKKB 0.882 -0.109 -2 0.721
PDHK1PDHK1 0.882 -0.121 1 0.902
NDR1NDR1 0.882 0.040 -3 0.846
PRKD2PRKD2 0.881 0.083 -3 0.769
LATS2LATS2 0.881 0.063 -5 0.796
MTORMTOR 0.881 -0.132 1 0.834
MST4MST4 0.880 0.078 2 0.894
RSK2RSK2 0.880 0.050 -3 0.763
ATRATR 0.880 0.008 1 0.895
NLKNLK 0.879 -0.025 1 0.846
CAMK2DCAMK2D 0.879 0.029 -3 0.857
WNK1WNK1 0.879 0.011 -2 0.829
P90RSKP90RSK 0.879 0.026 -3 0.767
PLK1PLK1 0.879 0.237 -2 0.895
ULK1ULK1 0.878 -0.072 -3 0.862
PKCDPKCD 0.877 0.087 2 0.832
SKMLCKSKMLCK 0.877 0.062 -2 0.810
NIKNIK 0.877 -0.026 -3 0.903
PIM1PIM1 0.876 0.067 -3 0.780
NUAK2NUAK2 0.876 0.000 -3 0.843
ATMATM 0.876 0.117 1 0.846
MARK4MARK4 0.876 -0.004 4 0.854
RSK3RSK3 0.876 0.016 -3 0.758
CDKL1CDKL1 0.876 -0.030 -3 0.792
CAMLCKCAMLCK 0.875 -0.016 -2 0.818
WNK3WNK3 0.875 -0.104 1 0.886
CAMK2BCAMK2B 0.875 0.099 2 0.865
NEK9NEK9 0.875 -0.004 2 0.868
MLK1MLK1 0.875 -0.039 2 0.840
DAPK2DAPK2 0.875 -0.008 -3 0.877
PKN2PKN2 0.874 0.015 -3 0.852
AMPKA1AMPKA1 0.874 0.018 -3 0.863
P70S6KBP70S6KB 0.874 0.022 -3 0.803
HUNKHUNK 0.874 -0.087 2 0.839
IKKAIKKA 0.874 -0.005 -2 0.714
ANKRD3ANKRD3 0.874 0.068 1 0.917
BCKDKBCKDK 0.873 -0.117 -1 0.803
ERK5ERK5 0.872 -0.057 1 0.777
PKACGPKACG 0.872 0.024 -2 0.729
TSSK2TSSK2 0.872 0.028 -5 0.848
PLK3PLK3 0.872 0.155 2 0.831
TSSK1TSSK1 0.872 0.063 -3 0.874
SRPK1SRPK1 0.871 0.044 -3 0.727
MAPKAPK3MAPKAPK3 0.871 -0.044 -3 0.783
MASTLMASTL 0.871 -0.189 -2 0.797
LATS1LATS1 0.870 0.139 -3 0.857
FAM20CFAM20C 0.870 0.088 2 0.633
CAMK4CAMK4 0.870 -0.033 -3 0.842
CHAK2CHAK2 0.870 -0.058 -1 0.866
NUAK1NUAK1 0.869 0.019 -3 0.804
AURCAURC 0.869 0.052 -2 0.631
GRK6GRK6 0.869 -0.052 1 0.871
GRK5GRK5 0.869 -0.188 -3 0.870
CDKL5CDKL5 0.868 -0.035 -3 0.783
ALK4ALK4 0.868 0.050 -2 0.818
PKRPKR 0.868 0.095 1 0.884
TGFBR1TGFBR1 0.868 0.074 -2 0.794
AMPKA2AMPKA2 0.868 0.004 -3 0.829
IRE2IRE2 0.867 0.030 2 0.779
CAMK2ACAMK2A 0.867 0.045 2 0.871
MAPKAPK2MAPKAPK2 0.867 -0.011 -3 0.733
NIM1NIM1 0.867 -0.056 3 0.838
SRPK2SRPK2 0.867 0.047 -3 0.654
HIPK4HIPK4 0.866 -0.034 1 0.798
KISKIS 0.866 0.014 1 0.689
MLK2MLK2 0.866 -0.084 2 0.846
GRK4GRK4 0.866 -0.084 -2 0.801
ACVR2AACVR2A 0.866 0.165 -2 0.846
BMPR1BBMPR1B 0.866 0.122 1 0.793
GRK1GRK1 0.866 -0.009 -2 0.712
DNAPKDNAPK 0.866 0.111 1 0.804
ICKICK 0.866 -0.046 -3 0.832
RIPK1RIPK1 0.865 -0.161 1 0.868
DLKDLK 0.865 -0.166 1 0.886
IRE1IRE1 0.865 -0.073 1 0.834
MNK2MNK2 0.865 0.015 -2 0.767
MELKMELK 0.864 -0.012 -3 0.818
AURBAURB 0.864 0.033 -2 0.627
PRKD3PRKD3 0.864 0.003 -3 0.734
MLK3MLK3 0.864 -0.003 2 0.771
ACVR2BACVR2B 0.864 0.149 -2 0.848
CHK1CHK1 0.863 0.020 -3 0.857
ALK2ALK2 0.863 0.101 -2 0.808
MSK2MSK2 0.863 -0.056 -3 0.729
TTBK2TTBK2 0.863 -0.138 2 0.739
RSK4RSK4 0.863 0.039 -3 0.726
PAK1PAK1 0.863 -0.030 -2 0.724
YSK4YSK4 0.862 -0.032 1 0.840
HRIHRI 0.862 0.075 -2 0.894
PKCAPKCA 0.862 0.028 2 0.761
PLK4PLK4 0.862 0.076 2 0.681
QSKQSK 0.862 -0.004 4 0.823
NEK2NEK2 0.862 -0.044 2 0.829
PAK3PAK3 0.862 -0.070 -2 0.729
MNK1MNK1 0.862 0.037 -2 0.779
TLK2TLK2 0.861 0.051 1 0.879
MSK1MSK1 0.861 0.001 -3 0.740
SRPK3SRPK3 0.861 0.034 -3 0.700
PHKG1PHKG1 0.861 -0.025 -3 0.839
PKCGPKCG 0.861 -0.004 2 0.769
QIKQIK 0.860 -0.090 -3 0.850
PKCBPKCB 0.860 0.016 2 0.767
MLK4MLK4 0.860 0.003 2 0.751
PERKPERK 0.860 0.075 -2 0.872
CDK8CDK8 0.860 -0.049 1 0.673
MEK1MEK1 0.859 -0.142 2 0.874
PKG2PKG2 0.859 0.038 -2 0.668
SMG1SMG1 0.859 0.008 1 0.850
PKACBPKACB 0.859 0.041 -2 0.662
SGK3SGK3 0.859 0.047 -3 0.763
VRK2VRK2 0.858 -0.146 1 0.910
SIKSIK 0.858 -0.031 -3 0.770
CLK4CLK4 0.858 0.008 -3 0.766
MEKK1MEKK1 0.858 0.037 1 0.885
MARK2MARK2 0.858 -0.010 4 0.751
BRSK2BRSK2 0.857 -0.061 -3 0.836
CLK1CLK1 0.857 0.031 -3 0.747
BRAFBRAF 0.857 0.026 -4 0.857
BRSK1BRSK1 0.857 -0.052 -3 0.797
PKCZPKCZ 0.856 -0.034 2 0.805
PKCHPKCH 0.856 -0.029 2 0.751
MARK3MARK3 0.856 -0.016 4 0.787
AURAAURA 0.856 -0.011 -2 0.588
MYLK4MYLK4 0.856 -0.044 -2 0.728
PAK2PAK2 0.855 -0.084 -2 0.710
DCAMKL1DCAMKL1 0.855 0.017 -3 0.789
TLK1TLK1 0.855 0.036 -2 0.848
CDK7CDK7 0.855 -0.048 1 0.669
PAK6PAK6 0.855 -0.018 -2 0.659
PRKXPRKX 0.854 0.079 -3 0.673
GRK7GRK7 0.854 0.036 1 0.793
BMPR1ABMPR1A 0.854 0.113 1 0.786
DRAK1DRAK1 0.853 -0.065 1 0.802
AKT2AKT2 0.853 0.004 -3 0.674
NEK5NEK5 0.853 0.041 1 0.888
WNK4WNK4 0.853 -0.052 -2 0.829
CDK19CDK19 0.852 -0.051 1 0.627
DYRK2DYRK2 0.852 -0.030 1 0.680
CAMK1GCAMK1G 0.852 -0.050 -3 0.764
CHAK1CHAK1 0.852 -0.144 2 0.777
PIM2PIM2 0.852 -0.002 -3 0.744
MARK1MARK1 0.852 -0.051 4 0.809
CDK5CDK5 0.852 0.011 1 0.685
DCAMKL2DCAMKL2 0.851 0.009 -3 0.822
ZAKZAK 0.851 -0.047 1 0.861
SNRKSNRK 0.850 -0.195 2 0.716
SMMLCKSMMLCK 0.850 -0.019 -3 0.824
PHKG2PHKG2 0.850 -0.025 -3 0.816
CDK1CDK1 0.850 0.010 1 0.608
IRAK4IRAK4 0.850 -0.041 1 0.852
JNK2JNK2 0.850 0.015 1 0.605
MAPKAPK5MAPKAPK5 0.849 -0.159 -3 0.718
PRP4PRP4 0.849 0.058 -3 0.817
JNK3JNK3 0.849 -0.007 1 0.647
P38AP38A 0.849 -0.024 1 0.684
CDK18CDK18 0.849 0.015 1 0.584
MEKK2MEKK2 0.849 -0.014 2 0.836
MEKK3MEKK3 0.848 -0.117 1 0.854
CDK2CDK2 0.848 -0.018 1 0.700
P70S6KP70S6K 0.848 -0.032 -3 0.707
PKACAPKACA 0.848 0.023 -2 0.614
PKCTPKCT 0.847 -0.015 2 0.766
CDK13CDK13 0.847 -0.062 1 0.637
CLK2CLK2 0.847 0.064 -3 0.737
MEK5MEK5 0.847 -0.224 2 0.858
SSTKSSTK 0.846 -0.000 4 0.829
CAMK1DCAMK1D 0.846 -0.007 -3 0.692
AKT1AKT1 0.846 0.012 -3 0.699
TAO3TAO3 0.845 -0.003 1 0.853
CDK17CDK17 0.845 -0.004 1 0.528
PLK2PLK2 0.844 0.119 -3 0.850
PINK1PINK1 0.844 -0.198 1 0.855
MST3MST3 0.843 -0.031 2 0.851
P38BP38B 0.843 -0.015 1 0.602
ERK2ERK2 0.843 -0.053 1 0.650
TTBK1TTBK1 0.843 -0.121 2 0.664
DYRK1ADYRK1A 0.843 -0.036 1 0.743
NEK8NEK8 0.843 -0.053 2 0.841
IRAK1IRAK1 0.842 -0.178 -1 0.779
CAMKK1CAMKK1 0.841 -0.122 -2 0.754
GRK2GRK2 0.841 -0.133 -2 0.672
ERK1ERK1 0.841 -0.037 1 0.598
CDK9CDK9 0.841 -0.082 1 0.645
HIPK1HIPK1 0.841 -0.018 1 0.700
DAPK3DAPK3 0.841 0.016 -3 0.801
TAO2TAO2 0.840 -0.048 2 0.883
P38GP38G 0.840 -0.013 1 0.520
PASKPASK 0.840 -0.056 -3 0.841
CDK12CDK12 0.840 -0.059 1 0.610
PKCIPKCI 0.840 -0.055 2 0.769
CDK14CDK14 0.839 -0.002 1 0.633
CDK3CDK3 0.839 0.041 1 0.545
GAKGAK 0.839 -0.014 1 0.856
NEK11NEK11 0.839 -0.130 1 0.864
CDK16CDK16 0.838 0.032 1 0.547
MST2MST2 0.838 -0.006 1 0.861
NEK4NEK4 0.837 -0.070 1 0.852
CAMKK2CAMKK2 0.837 -0.118 -2 0.745
PAK5PAK5 0.837 -0.060 -2 0.588
LKB1LKB1 0.837 -0.087 -3 0.874
GSK3BGSK3B 0.837 -0.025 4 0.460
MRCKAMRCKA 0.836 0.031 -3 0.771
HIPK2HIPK2 0.835 -0.023 1 0.585
PKN1PKN1 0.835 -0.028 -3 0.727
DYRK4DYRK4 0.835 -0.018 1 0.602
DYRK1BDYRK1B 0.835 -0.028 1 0.633
PKCEPKCE 0.834 -0.010 2 0.744
GCKGCK 0.834 -0.020 1 0.850
HIPK3HIPK3 0.834 -0.075 1 0.707
CK2A2CK2A2 0.834 0.055 1 0.711
PDK1PDK1 0.834 -0.084 1 0.877
TNIKTNIK 0.834 0.030 3 0.878
MPSK1MPSK1 0.834 -0.085 1 0.813
TTKTTK 0.834 0.311 -2 0.891
P38DP38D 0.834 0.001 1 0.553
EEF2KEEF2K 0.834 -0.017 3 0.849
HGKHGK 0.834 -0.029 3 0.875
GSK3AGSK3A 0.833 0.008 4 0.469
MINKMINK 0.833 -0.024 1 0.856
DYRK3DYRK3 0.833 -0.043 1 0.706
PAK4PAK4 0.833 -0.060 -2 0.592
SGK1SGK1 0.833 0.016 -3 0.591
MRCKBMRCKB 0.832 0.015 -3 0.744
AKT3AKT3 0.832 0.006 -3 0.603
ROCK2ROCK2 0.832 0.050 -3 0.797
NEK1NEK1 0.832 -0.047 1 0.860
CAMK1ACAMK1A 0.832 -0.023 -3 0.649
LOKLOK 0.832 -0.029 -2 0.772
TAK1TAK1 0.831 -0.074 1 0.907
MST1MST1 0.831 -0.019 1 0.850
CK1ECK1E 0.831 -0.121 -3 0.523
MAP3K15MAP3K15 0.831 -0.099 1 0.846
DAPK1DAPK1 0.831 -0.039 -3 0.778
CDK10CDK10 0.830 -0.019 1 0.616
RIPK2RIPK2 0.829 -0.184 1 0.826
MEKK6MEKK6 0.829 -0.133 1 0.852
VRK1VRK1 0.829 -0.107 2 0.867
CHK2CHK2 0.829 -0.053 -3 0.628
MEK2MEK2 0.828 -0.155 2 0.843
LRRK2LRRK2 0.828 -0.182 2 0.874
CK1G1CK1G1 0.828 -0.117 -3 0.522
ERK7ERK7 0.827 -0.045 2 0.537
KHS1KHS1 0.826 -0.003 1 0.839
HPK1HPK1 0.825 -0.083 1 0.831
DMPK1DMPK1 0.825 0.053 -3 0.763
YSK1YSK1 0.825 -0.062 2 0.834
STK33STK33 0.824 -0.156 2 0.671
GRK3GRK3 0.824 -0.136 -2 0.618
SLKSLK 0.824 -0.086 -2 0.707
NEK3NEK3 0.824 -0.070 1 0.838
JNK1JNK1 0.823 -0.043 1 0.589
KHS2KHS2 0.823 0.007 1 0.847
PKG1PKG1 0.823 -0.013 -2 0.589
CK2A1CK2A1 0.822 0.017 1 0.686
CK1DCK1D 0.822 -0.121 -3 0.473
CDK6CDK6 0.821 -0.042 1 0.616
PDHK3_TYRPDHK3_TYR 0.821 0.160 4 0.918
CDK4CDK4 0.821 -0.046 1 0.596
SBKSBK 0.820 -0.046 -3 0.552
PBKPBK 0.819 -0.054 1 0.779
ROCK1ROCK1 0.819 0.014 -3 0.766
BUB1BUB1 0.818 -0.011 -5 0.792
CK1A2CK1A2 0.818 -0.125 -3 0.468
CRIKCRIK 0.816 0.010 -3 0.692
OSR1OSR1 0.816 -0.024 2 0.840
MAKMAK 0.814 -0.016 -2 0.671
TESK1_TYRTESK1_TYR 0.813 -0.059 3 0.899
MOKMOK 0.812 -0.043 1 0.692
ALPHAK3ALPHAK3 0.812 -0.017 -1 0.798
BIKEBIKE 0.812 0.006 1 0.719
TAO1TAO1 0.811 -0.058 1 0.802
PDHK4_TYRPDHK4_TYR 0.811 0.022 2 0.925
ASK1ASK1 0.811 -0.119 1 0.835
EPHA6EPHA6 0.811 0.122 -1 0.876
MAP2K4_TYRMAP2K4_TYR 0.810 -0.094 -1 0.893
MYO3BMYO3B 0.810 -0.059 2 0.840
PKMYT1_TYRPKMYT1_TYR 0.810 -0.087 3 0.889
MAP2K7_TYRMAP2K7_TYR 0.809 -0.195 2 0.895
MAP2K6_TYRMAP2K6_TYR 0.808 -0.057 -1 0.892
HASPINHASPIN 0.808 -0.028 -1 0.720
MYO3AMYO3A 0.807 -0.067 1 0.837
RETRET 0.807 0.009 1 0.866
MST1RMST1R 0.807 0.045 3 0.882
PINK1_TYRPINK1_TYR 0.807 -0.159 1 0.878
LIMK2_TYRLIMK2_TYR 0.807 -0.033 -3 0.919
BMPR2_TYRBMPR2_TYR 0.807 -0.045 -1 0.876
EPHB4EPHB4 0.807 0.089 -1 0.866
PDHK1_TYRPDHK1_TYR 0.806 -0.081 -1 0.911
CSF1RCSF1R 0.805 0.083 3 0.870
DDR1DDR1 0.805 -0.003 4 0.868
TYK2TYK2 0.805 -0.024 1 0.869
ROS1ROS1 0.804 0.029 3 0.843
TYRO3TYRO3 0.803 -0.015 3 0.857
JAK2JAK2 0.803 -0.009 1 0.869
JAK3JAK3 0.802 0.048 1 0.856
INSRRINSRR 0.802 0.064 3 0.833
TXKTXK 0.801 0.142 1 0.840
LIMK1_TYRLIMK1_TYR 0.800 -0.190 2 0.882
YES1YES1 0.800 0.043 -1 0.876
STLK3STLK3 0.799 -0.139 1 0.823
YANK3YANK3 0.799 -0.095 2 0.461
ABL2ABL2 0.798 0.021 -1 0.842
EPHA4EPHA4 0.798 0.026 2 0.825
FGFR2FGFR2 0.798 0.012 3 0.877
TNK2TNK2 0.798 0.058 3 0.842
BLKBLK 0.797 0.157 -1 0.862
HCKHCK 0.797 0.023 -1 0.855
KDRKDR 0.797 0.059 3 0.861
SRMSSRMS 0.797 0.029 1 0.868
FGRFGR 0.796 -0.042 1 0.862
PDGFRBPDGFRB 0.796 -0.016 3 0.874
EPHB1EPHB1 0.796 0.016 1 0.873
KITKIT 0.796 0.004 3 0.869
FERFER 0.796 -0.071 1 0.889
EPHB3EPHB3 0.796 0.028 -1 0.849
LCKLCK 0.796 0.082 -1 0.856
JAK1JAK1 0.795 0.067 1 0.825
EPHB2EPHB2 0.795 0.050 -1 0.849
FGFR1FGFR1 0.795 -0.007 3 0.849
AXLAXL 0.794 0.025 3 0.866
TEKTEK 0.794 -0.035 3 0.815
NEK10_TYRNEK10_TYR 0.793 -0.046 1 0.758
FLT3FLT3 0.793 -0.038 3 0.854
ITKITK 0.793 0.004 -1 0.830
ABL1ABL1 0.792 -0.030 -1 0.835
AAK1AAK1 0.792 0.034 1 0.602
MERTKMERTK 0.792 0.033 3 0.859
TECTEC 0.792 0.030 -1 0.780
TNK1TNK1 0.791 -0.046 3 0.837
DDR2DDR2 0.791 0.090 3 0.833
PDGFRAPDGFRA 0.791 -0.072 3 0.873
EPHA7EPHA7 0.791 0.046 2 0.827
TNNI3K_TYRTNNI3K_TYR 0.791 -0.008 1 0.867
EPHA1EPHA1 0.789 0.040 3 0.852
NTRK1NTRK1 0.788 -0.063 -1 0.839
LTKLTK 0.788 -0.054 3 0.822
METMET 0.787 -0.023 3 0.861
ALKALK 0.787 -0.068 3 0.798
FLT1FLT1 0.787 -0.001 -1 0.856
FLT4FLT4 0.787 -0.031 3 0.845
FGFR3FGFR3 0.787 -0.018 3 0.861
EPHA3EPHA3 0.786 -0.049 2 0.803
NTRK2NTRK2 0.786 -0.049 3 0.849
BMXBMX 0.786 -0.020 -1 0.753
FYNFYN 0.785 0.040 -1 0.829
FRKFRK 0.785 -0.003 -1 0.871
BTKBTK 0.785 -0.126 -1 0.800
EPHA5EPHA5 0.784 0.040 2 0.813
LYNLYN 0.784 -0.003 3 0.798
ERBB2ERBB2 0.783 -0.106 1 0.819
PTK6PTK6 0.783 -0.153 -1 0.766
INSRINSR 0.782 -0.075 3 0.809
PTK2BPTK2B 0.781 -0.006 -1 0.813
NTRK3NTRK3 0.780 -0.061 -1 0.790
EPHA8EPHA8 0.780 -0.001 -1 0.828
WEE1_TYRWEE1_TYR 0.779 -0.145 -1 0.778
CK1ACK1A 0.778 -0.167 -3 0.376
EGFREGFR 0.776 -0.031 1 0.727
SRCSRC 0.775 -0.045 -1 0.833
FGFR4FGFR4 0.773 -0.034 -1 0.803
MATKMATK 0.772 -0.126 -1 0.771
CSKCSK 0.771 -0.131 2 0.827
EPHA2EPHA2 0.771 -0.006 -1 0.795
PTK2PTK2 0.769 -0.006 -1 0.786
IGF1RIGF1R 0.768 -0.093 3 0.753
YANK2YANK2 0.764 -0.131 2 0.476
MUSKMUSK 0.763 -0.150 1 0.708
CK1G3CK1G3 0.763 -0.144 -3 0.324
SYKSYK 0.761 -0.059 -1 0.786
ERBB4ERBB4 0.760 -0.049 1 0.719
FESFES 0.751 -0.142 -1 0.731
CK1G2CK1G2 0.738 -0.170 -3 0.431
ZAP70ZAP70 0.732 -0.131 -1 0.701