Motif 604 (n=248)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H7BYZ3 | None | S25 | ochoa | EF-hand domain-containing protein | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000256|ARBA:ARBA00023754}. |
| O14617 | AP3D1 | S721 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O14777 | NDC80 | S44 | psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15014 | ZNF609 | S846 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15400 | STX7 | S75 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15438 | ABCC3 | S908 | ochoa | ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}. |
| O15439 | ABCC4 | S629 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43399 | TPD52L2 | S161 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43422 | THAP12 | S135 | ochoa | 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) | Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. |
| O43432 | EIF4G3 | S1165 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43491 | EPB41L2 | S881 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43493 | TGOLN2 | S221 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43566 | RGS14 | S288 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60361 | NME2P1 | S105 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60486 | PLXNC1 | S978 | ochoa | Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) | Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:20727575}. |
| O60524 | NEMF | S833 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60814 | H2BC12 | S65 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O60841 | EIF5B | S182 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60885 | BRD4 | S593 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75348 | ATP6V1G1 | S65 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75363 | BCAS1 | S386 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75369 | FLNB | S2325 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75410 | TACC1 | S248 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75496 | GMNN | S34 | ochoa | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| O75995 | SASH3 | S349 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O76021 | RSL1D1 | S413 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O94986 | CEP152 | S1614 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95235 | KIF20A | S44 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95749 | GGPS1 | S203 | ochoa | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. {ECO:0000269|PubMed:32403198}. |
| O95801 | TTC4 | S234 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| O95831 | AIFM1 | S100 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P07550 | ADRB2 | S355 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07942 | LAMB1 | S1666 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P10451 | SPP1 | S275 | ochoa | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10721 | KIT | S891 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11021 | HSPA5 | S301 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P13521 | SCG2 | S532 | ochoa|psp | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P14625 | HSP90B1 | S347 | psp | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15260 | IFNGR1 | S310 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P15531 | NME1 | S120 | ochoa|psp | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P22392 | NME2 | S120 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P22694 | PRKACB | T325 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P23193 | TCEA1 | S81 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P23396 | RPS3 | S209 | ochoa|psp | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P27797 | CALR | S214 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P27797 | CALR | S231 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P29536 | LMOD1 | S133 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P31249 | HOXD3 | S261 | ochoa | Homeobox protein Hox-D3 (Homeobox protein Hox-4A) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P35579 | MYH9 | S1111 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35606 | COPB2 | S175 | ochoa | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| P35749 | MYH11 | S1291 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37198 | NUP62 | Y422 | ochoa|psp | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P37275 | ZEB1 | S342 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P39748 | FEN1 | S352 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P41236 | PPP1R2 | S23 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P42684 | ABL2 | S275 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P43243 | MATR3 | S596 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P49792 | RANBP2 | S1422 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50238 | CRIP1 | S40 | ochoa | Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP) | Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. |
| P50851 | LRBA | S1247 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51858 | HDGF | S103 | ochoa | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52565 | ARHGDIA | S148 | ochoa | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52566 | ARHGDIB | S145 | ochoa | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P52756 | RBM5 | Y620 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P54132 | BLM | S1280 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54259 | ATN1 | S73 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55072 | VCP | S284 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P57053 | H2BC12L | S65 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | S65 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P60709 | ACTB | Y198 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | Y200 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P62807 | H2BC4 | S65 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P63098 | PPP3R1 | S35 | ochoa | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000269|PubMed:26794871}. |
| P63261 | ACTG1 | Y198 | ochoa|psp | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | Y199 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | Y200 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | Y200 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78536 | ADAM17 | S786 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| Q02241 | KIF23 | S889 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q03701 | CEBPZ | S974 | ochoa | CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) | Stimulates transcription from the HSP70 promoter. |
| Q05084 | ICA1 | S291 | ochoa | Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) | May play a role in neurotransmitter secretion. {ECO:0000250}. |
| Q08945 | SSRP1 | S657 | psp | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q08945 | SSRP1 | S668 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09666 | AHNAK | S440 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S637 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3031 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3483 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1168 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12830 | BPTF | S1133 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12834 | CDC20 | S104 | ochoa | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12872 | SFSWAP | S279 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12872 | SFSWAP | S618 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13042 | CDC16 | S560 | ochoa|psp | Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q13433 | SLC39A6 | S475 | ochoa | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}. |
| Q13442 | PDAP1 | S60 | ochoa | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}. |
| Q13547 | HDAC1 | S410 | ochoa | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q14204 | DYNC1H1 | S688 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14315 | FLNC | S2598 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14498 | RBM39 | S23 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14739 | LBR | S130 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14789 | GOLGB1 | S2216 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14847 | LASP1 | S82 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14847 | LASP1 | S99 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14847 | LASP1 | S118 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14966 | ZNF638 | S299 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14966 | ZNF638 | S1825 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14978 | NOLC1 | S623 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15059 | BRD3 | S558 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15121 | PEA15 | S61 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q15185 | PTGES3 | S72 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15390 | MTFR1 | S119 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q15390 | MTFR1 | Y286 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q15468 | STIL | S1131 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15678 | PTPN14 | S534 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16625 | OCLN | S277 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16778 | H2BC21 | S65 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q2LD37 | BLTP1 | S3636 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q53QV2 | LBH | S63 | ochoa | Protein LBH (hLBH) (Limb bud and heart development protein homolog) | Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway. {ECO:0000269|PubMed:17390236}. |
| Q5QNW6 | H2BC18 | S65 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5T035 | FAM120A2P | S66 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T0W9 | FAM83B | S424 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T5P2 | KIAA1217 | S1628 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T7W7 | TSTD2 | S283 | ochoa | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) | None |
| Q5VZK9 | CARMIL1 | S880 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q66GS9 | CEP135 | S356 | ochoa | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}. |
| Q685J3 | MUC17 | S4428 | ochoa | Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3) | Probably plays a role in maintaining homeostasis on mucosal surfaces. {ECO:0000269|PubMed:17990980}. |
| Q6DN12 | MCTP2 | S735 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6JBY9 | RCSD1 | S219 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NXS1 | PPP1R2B | S23 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6PD62 | CTR9 | S941 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PJW8 | CNST | S293 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q71F23 | CENPU | S96 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q76L83 | ASXL2 | S439 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q76N89 | HECW1 | S536 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7L014 | DDX46 | Y910 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
| Q7L2J0 | MEPCE | S240 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2W7 | TRPM8 | S1041 | psp | Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186). {ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:15306801, ECO:0000269|PubMed:15852009, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:25559186, ECO:0000269|PubMed:37857704}.; FUNCTION: [Isoform 2]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}.; FUNCTION: [Isoform 3]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}. |
| Q7Z3J2 | VPS35L | S108 | ochoa | VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein) | Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| Q86TC9 | MYPN | S197 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86TI0 | TBC1D1 | S69 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86V48 | LUZP1 | S57 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86V48 | LUZP1 | S569 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VH2 | KIF27 | S643 | ochoa | Kinesin-like protein KIF27 | Plays an essential role in motile ciliogenesis. {ECO:0000250}. |
| Q86VY9 | TMEM200A | S466 | ochoa | Transmembrane protein 200A | None |
| Q8IUX4 | APOBEC3F | S216 | psp | DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:15141007, PubMed:20062055, PubMed:22915799, PubMed:34774569). Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 (PubMed:15141007, PubMed:15152192, PubMed:20219927, PubMed:21835787, PubMed:22807680, PubMed:23001005, PubMed:23097438, PubMed:23152537, PubMed:34774569). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:15141007). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells (PubMed:15141007). Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (PubMed:15141007). Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons (PubMed:16378963, PubMed:16527742, PubMed:19458006, PubMed:20062055, PubMed:20335265). May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:15141007, ECO:0000269|PubMed:15152192, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23001005, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537, ECO:0000269|PubMed:34774569}. |
| Q8IVF2 | AHNAK2 | S2661 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S5395 | ochoa | Protein AHNAK2 | None |
| Q8IWY8 | ZSCAN29 | S132 | ochoa | Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) | May be involved in transcriptional regulation. |
| Q8N257 | H2BC26 | S65 | ochoa | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8N3X1 | FNBP4 | S659 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NCN4 | RNF169 | S542 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NCW6 | GALNT11 | S82 | ochoa | Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) | Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:16207894, ECO:0000269|PubMed:24226769}. |
| Q8NEL9 | DDHD1 | S224 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NEM2 | SHCBP1 | S574 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8TDP1 | RNASEH2C | S102 | ochoa | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| Q8WUB8 | PHF10 | S321 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WUF8 | ARB2A | S215 | ochoa | Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) | Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}. |
| Q8WWH5 | TRUB1 | S211 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WWI1 | LMO7 | S1012 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXA9 | SREK1 | S171 | ochoa | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}. |
| Q8WYP5 | AHCTF1 | S1278 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WZA1 | POMGNT1 | S66 | ochoa | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2) | Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191, ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613, ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216, ECO:0000269|PubMed:28512129}. |
| Q92922 | SMARCC1 | S825 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q93079 | H2BC9 | S65 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96MW1 | CCDC43 | Y135 | ochoa | Coiled-coil domain-containing protein 43 | None |
| Q96N64 | PWWP2A | S535 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96NB3 | ZNF830 | S223 | ochoa | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}. |
| Q96NL8 | CFAP418 | S65 | ochoa | Cilia- and flagella-associated protein 418 | May be involved in photoreceptor outer segment disk morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UJP5}. |
| Q96RL1 | UIMC1 | S171 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RU3 | FNBP1 | S299 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q99590 | SCAF11 | S608 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99801 | NKX3-1 | S185 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q99848 | EBNA1BP2 | S207 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q99877 | H2BC15 | S65 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S65 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | S65 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99959 | PKP2 | S650 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BS34 | ZNF670 | S64 | ochoa | Zinc finger protein 670 | May be involved in transcriptional regulation. |
| Q9BST9 | RTKN | S30 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BSV6 | TSEN34 | S131 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BW66 | CINP | S68 | ochoa | Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) | Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q9BY42 | RTF2 | S286 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9BY84 | DUSP16 | S609 | ochoa | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
| Q9H2G2 | SLK | S546 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2P0 | ADNP | S736 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4L7 | SMARCAD1 | S124 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H6X5 | C19orf44 | S239 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9H6Z4 | RANBP3 | S240 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H792 | PEAK1 | S214 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H8V3 | ECT2 | S38 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9A5 | CNOT10 | S20 | ochoa | CCR4-NOT transcription complex subunit 10 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}. |
| Q9H9A6 | LRRC40 | S375 | ochoa | Leucine-rich repeat-containing protein 40 | None |
| Q9HCE1 | MOV10 | S791 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9HDC5 | JPH1 | S625 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NRF9 | POLE3 | S67 | ochoa | DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000250|UniProtKB:Q04603, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:14759371}. |
| Q9NRM7 | LATS2 | S1027 | ochoa | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NRY5 | FAM114A2 | S270 | ochoa | Protein FAM114A2 | None |
| Q9NS28 | RGS18 | S49 | ochoa|psp | Regulator of G-protein signaling 18 (RGS18) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. {ECO:0000269|PubMed:11042171, ECO:0000269|PubMed:11955952}. |
| Q9NSI6 | BRWD1 | S2118 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NXV6 | CDKN2AIP | S131 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9NYL9 | TMOD3 | S155 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZB2 | FAM120A | S417 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZM1 | MYOF | S1036 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9P212 | PLCE1 | S1096 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9UHD8 | SEPTIN9 | S327 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UIF8 | BAZ2B | S1269 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UIG0 | BAZ1B | S1342 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKX2 | MYH2 | S1741 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULU4 | ZMYND8 | S53 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UN76 | SLC6A14 | S22 | ochoa | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14) | Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:10446133). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766). {ECO:0000250|UniProtKB:Q9JMA9, ECO:0000269|PubMed:10446133, ECO:0000269|PubMed:17855766, ECO:0000269|PubMed:18599538}. |
| Q9UPQ0 | LIMCH1 | S379 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPS6 | SETD1B | S986 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UQM7 | CAMK2A | S257 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y266 | NUDC | S304 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y3Q8 | TSC22D4 | S190 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y3T9 | NOC2L | S672 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y3X0 | CCDC9 | S362 | ochoa | Coiled-coil domain-containing protein 9 | Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}. |
| Q9Y520 | PRRC2C | S1263 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5A7 | NUB1 | S46 | psp | NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}. |
| Q9H3H1 | TRIT1 | S431 | Sugiyama | tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) | Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054). TRIT1 is therefore required for selenoprotein expression (PubMed:24126054). {ECO:0000269|PubMed:11111046, ECO:0000269|PubMed:24126054, ECO:0000269|PubMed:24901367, ECO:0000269|PubMed:34774131}. |
| P34932 | HSPA4 | S363 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35579 | MYH9 | S1308 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P46060 | RANGAP1 | S50 | Sugiyama | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| O14965 | AURKA | S104 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P23381 | WARS1 | S378 | Sugiyama | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| O60285 | NUAK1 | S380 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O00488 | ZNF593 | S93 | Sugiyama | Zinc finger protein 593 (Zinc finger protein T86) | Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547). Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366). {ECO:0000269|PubMed:9115366, ECO:0000305|PubMed:32669547}. |
| Q13085 | ACACA | S1766 | Sugiyama | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13242 | SRSF9 | Y35 | Sugiyama | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| P05771 | PRKCB | S311 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P46778 | RPL21 | S104 | Sugiyama | Large ribosomal subunit protein eL21 (60S ribosomal protein L21) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. |
| Q9NYK5 | MRPL39 | S57 | Sugiyama | Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5) | None |
| O75400 | PRPF40A | S927 | Sugiyama | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q92614 | MYO18A | S1465 | Sugiyama | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q96S66 | CLCC1 | S59 | Sugiyama | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q99816 | TSG101 | S299 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9Y4W2 | LAS1L | S636 | Sugiyama | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| P08238 | HSP90AB1 | S417 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q92997 | DVL3 | S263 | GPS6 | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96GM8 | TOE1 | S374 | Sugiyama | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q12874 | SF3A3 | S76 | Sugiyama | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| P62913 | RPL11 | S59 | Sugiyama | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| Q8TEU7 | RAPGEF6 | S1117 | Sugiyama | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| O14910 | LIN7A | S157 | Sugiyama | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
| Q9NUP9 | LIN7C | S142 | Sugiyama | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}. |
| P29144 | TPP2 | S25 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| Q9BYP7 | WNK3 | S47 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9H4A3 | WNK1 | S198 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.142864e-12 | 11.942 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.344902e-12 | 11.630 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 6.059486e-12 | 11.218 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 9.219070e-12 | 11.035 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.654998e-11 | 10.781 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.654998e-11 | 10.781 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.605804e-11 | 10.794 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.918554e-11 | 10.717 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.918554e-11 | 10.717 |
| R-HSA-5334118 | DNA methylation | 3.070832e-11 | 10.513 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.664780e-11 | 10.247 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.777279e-11 | 10.169 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 7.263956e-11 | 10.139 |
| R-HSA-3214815 | HDACs deacetylate histones | 8.367917e-11 | 10.077 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 9.526813e-11 | 10.021 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.468126e-11 | 10.024 |
| R-HSA-774815 | Nucleosome assembly | 1.589022e-10 | 9.799 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.589022e-10 | 9.799 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.604081e-10 | 9.795 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.466240e-10 | 9.834 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.473889e-10 | 9.832 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.604081e-10 | 9.795 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.756932e-10 | 9.755 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.631028e-10 | 9.580 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.944875e-10 | 9.531 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.339155e-10 | 9.476 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.339155e-10 | 9.476 |
| R-HSA-73927 | Depurination | 4.213857e-10 | 9.375 |
| R-HSA-912446 | Meiotic recombination | 5.272637e-10 | 9.278 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 6.603738e-10 | 9.180 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.772867e-10 | 9.169 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 8.204518e-10 | 9.086 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 8.204518e-10 | 9.086 |
| R-HSA-418990 | Adherens junctions interactions | 8.890355e-10 | 9.051 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.079336e-09 | 8.967 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.202015e-09 | 8.920 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.255248e-09 | 8.901 |
| R-HSA-68886 | M Phase | 1.287336e-09 | 8.890 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.248656e-09 | 8.904 |
| R-HSA-73928 | Depyrimidination | 1.248656e-09 | 8.904 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.358129e-09 | 8.867 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.456793e-09 | 8.837 |
| R-HSA-9710421 | Defective pyroptosis | 1.530143e-09 | 8.815 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.950340e-09 | 8.710 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.507763e-09 | 8.601 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.590978e-09 | 8.587 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.746977e-09 | 8.561 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.416776e-09 | 8.466 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.474205e-09 | 8.349 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.106975e-09 | 8.292 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.420749e-09 | 8.192 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 8.022776e-09 | 8.096 |
| R-HSA-421270 | Cell-cell junction organization | 8.373904e-09 | 8.077 |
| R-HSA-446728 | Cell junction organization | 8.623889e-09 | 8.064 |
| R-HSA-5693538 | Homology Directed Repair | 9.361993e-09 | 8.029 |
| R-HSA-1221632 | Meiotic synapsis | 9.483747e-09 | 8.023 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.117768e-08 | 7.952 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.404978e-08 | 7.852 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.404978e-08 | 7.852 |
| R-HSA-73884 | Base Excision Repair | 1.761520e-08 | 7.754 |
| R-HSA-1640170 | Cell Cycle | 2.203216e-08 | 7.657 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.357586e-08 | 7.628 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.780574e-08 | 7.556 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.862587e-08 | 7.413 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.781506e-08 | 7.422 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.781506e-08 | 7.422 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.287527e-08 | 7.368 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.611768e-08 | 7.336 |
| R-HSA-157579 | Telomere Maintenance | 4.786740e-08 | 7.320 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.326627e-08 | 7.274 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.301760e-08 | 7.201 |
| R-HSA-1500931 | Cell-Cell communication | 6.923232e-08 | 7.160 |
| R-HSA-1500620 | Meiosis | 7.557169e-08 | 7.122 |
| R-HSA-68875 | Mitotic Prophase | 8.134211e-08 | 7.090 |
| R-HSA-73886 | Chromosome Maintenance | 8.895420e-08 | 7.051 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 9.256308e-08 | 7.034 |
| R-HSA-211000 | Gene Silencing by RNA | 1.438396e-07 | 6.842 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.630390e-07 | 6.788 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.523095e-07 | 6.598 |
| R-HSA-69306 | DNA Replication | 2.567424e-07 | 6.591 |
| R-HSA-977225 | Amyloid fiber formation | 4.028497e-07 | 6.395 |
| R-HSA-3214847 | HATs acetylate histones | 4.423688e-07 | 6.354 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 5.200668e-07 | 6.284 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.554275e-07 | 6.255 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.848630e-07 | 6.233 |
| R-HSA-4839726 | Chromatin organization | 8.193107e-07 | 6.087 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.246402e-07 | 6.034 |
| R-HSA-69481 | G2/M Checkpoints | 1.022687e-06 | 5.990 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.537802e-06 | 5.813 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.649019e-06 | 5.783 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.658435e-06 | 5.780 |
| R-HSA-8852135 | Protein ubiquitination | 1.704327e-06 | 5.768 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.984600e-06 | 5.702 |
| R-HSA-195721 | Signaling by WNT | 2.103760e-06 | 5.677 |
| R-HSA-157118 | Signaling by NOTCH | 2.258617e-06 | 5.646 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.560395e-06 | 5.449 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.160980e-06 | 5.381 |
| R-HSA-5688426 | Deubiquitination | 4.703162e-06 | 5.328 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.051324e-06 | 5.297 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.137841e-06 | 5.212 |
| R-HSA-73894 | DNA Repair | 7.331351e-06 | 5.135 |
| R-HSA-1474165 | Reproduction | 7.834304e-06 | 5.106 |
| R-HSA-9610379 | HCMV Late Events | 9.562793e-06 | 5.019 |
| R-HSA-2262752 | Cellular responses to stress | 1.075060e-05 | 4.969 |
| R-HSA-9609690 | HCMV Early Events | 1.865974e-05 | 4.729 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.278438e-05 | 4.642 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.809687e-05 | 4.551 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.809687e-05 | 4.551 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.809687e-05 | 4.551 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.478851e-05 | 4.606 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.491827e-05 | 4.603 |
| R-HSA-8939211 | ESR-mediated signaling | 3.288569e-05 | 4.483 |
| R-HSA-2559583 | Cellular Senescence | 3.584759e-05 | 4.446 |
| R-HSA-9609646 | HCMV Infection | 5.701286e-05 | 4.244 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.186459e-04 | 3.926 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.044082e-04 | 3.690 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.044082e-04 | 3.690 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.531901e-04 | 3.597 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.353022e-04 | 3.271 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.366903e-04 | 3.270 |
| R-HSA-9764561 | Regulation of CDH1 Function | 8.399654e-04 | 3.076 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.053946e-03 | 2.977 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.314566e-03 | 2.881 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.339751e-03 | 2.873 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.737001e-03 | 2.760 |
| R-HSA-3371556 | Cellular response to heat stress | 2.079753e-03 | 2.682 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.079753e-03 | 2.682 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.081682e-03 | 2.682 |
| R-HSA-68882 | Mitotic Anaphase | 2.206324e-03 | 2.656 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.278532e-03 | 2.642 |
| R-HSA-68877 | Mitotic Prometaphase | 3.176638e-03 | 2.498 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.516764e-03 | 2.454 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.579905e-03 | 2.446 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.716503e-03 | 2.430 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 4.086248e-03 | 2.389 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.086248e-03 | 2.389 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 4.617193e-03 | 2.336 |
| R-HSA-9824446 | Viral Infection Pathways | 5.321824e-03 | 2.274 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.550414e-03 | 2.122 |
| R-HSA-597592 | Post-translational protein modification | 7.903560e-03 | 2.102 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 8.657764e-03 | 2.063 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 8.031845e-03 | 2.095 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 8.031845e-03 | 2.095 |
| R-HSA-162587 | HIV Life Cycle | 9.497190e-03 | 2.022 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.028517e-02 | 1.988 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.071922e-02 | 1.970 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.131791e-02 | 1.946 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.228064e-02 | 1.911 |
| R-HSA-196025 | Formation of annular gap junctions | 1.469971e-02 | 1.833 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.469971e-02 | 1.833 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669921 | KIT mutants bind TKIs | 1.644456e-02 | 1.784 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 1.644456e-02 | 1.784 |
| R-HSA-190873 | Gap junction degradation | 1.730593e-02 | 1.762 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.535863e-02 | 1.814 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.535863e-02 | 1.814 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.808863e-02 | 1.743 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.808863e-02 | 1.743 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.669219e-02 | 1.777 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.844694e-02 | 1.734 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.834892e-02 | 1.736 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.730593e-02 | 1.762 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.810836e-02 | 1.742 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.665309e-02 | 1.779 |
| R-HSA-162582 | Signal Transduction | 1.677767e-02 | 1.775 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.679476e-02 | 1.775 |
| R-HSA-5663205 | Infectious disease | 1.692893e-02 | 1.771 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.946038e-02 | 1.711 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.946038e-02 | 1.711 |
| R-HSA-212436 | Generic Transcription Pathway | 1.951009e-02 | 1.710 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.954815e-02 | 1.709 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.954815e-02 | 1.709 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.021050e-02 | 1.694 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.026513e-02 | 1.693 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.107088e-02 | 1.676 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.195889e-02 | 1.658 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.305291e-02 | 1.637 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.618067e-02 | 1.582 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.658791e-02 | 1.575 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.676467e-02 | 1.572 |
| R-HSA-74160 | Gene expression (Transcription) | 2.892201e-02 | 1.539 |
| R-HSA-390522 | Striated Muscle Contraction | 2.963300e-02 | 1.528 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.030686e-02 | 1.518 |
| R-HSA-373755 | Semaphorin interactions | 3.149056e-02 | 1.502 |
| R-HSA-1280218 | Adaptive Immune System | 3.266962e-02 | 1.486 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 3.291340e-02 | 1.483 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.349829e-02 | 1.475 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.431968e-02 | 1.464 |
| R-HSA-3371511 | HSF1 activation | 3.552440e-02 | 1.449 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.578791e-02 | 1.446 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 3.650632e-02 | 1.438 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 4.812223e-02 | 1.318 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 4.812223e-02 | 1.318 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.424336e-02 | 1.354 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.424336e-02 | 1.354 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.707094e-02 | 1.327 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.424336e-02 | 1.354 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.976180e-02 | 1.401 |
| R-HSA-167169 | HIV Transcription Elongation | 4.424336e-02 | 1.354 |
| R-HSA-196780 | Biotin transport and metabolism | 4.024251e-02 | 1.395 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.197229e-02 | 1.377 |
| R-HSA-397014 | Muscle contraction | 4.132395e-02 | 1.384 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.812223e-02 | 1.318 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 4.024251e-02 | 1.395 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 4.852981e-02 | 1.314 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 4.852981e-02 | 1.314 |
| R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 4.852981e-02 | 1.314 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 4.852981e-02 | 1.314 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.882638e-02 | 1.311 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.896521e-02 | 1.310 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.896521e-02 | 1.310 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.959969e-02 | 1.305 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.959969e-02 | 1.305 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.061758e-02 | 1.296 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.105642e-02 | 1.292 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 5.225491e-02 | 1.282 |
| R-HSA-1266738 | Developmental Biology | 5.244582e-02 | 1.280 |
| R-HSA-162906 | HIV Infection | 5.559053e-02 | 1.255 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 5.650913e-02 | 1.248 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 5.650913e-02 | 1.248 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.010684e-02 | 1.221 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 6.087982e-02 | 1.216 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.179115e-02 | 1.209 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.179115e-02 | 1.209 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.179115e-02 | 1.209 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.179115e-02 | 1.209 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.285743e-02 | 1.202 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.355291e-02 | 1.197 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 6.417921e-02 | 1.193 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 6.417921e-02 | 1.193 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 6.536202e-02 | 1.185 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.646446e-02 | 1.177 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.833043e-02 | 1.165 |
| R-HSA-73887 | Death Receptor Signaling | 6.868075e-02 | 1.163 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 6.995092e-02 | 1.155 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 6.995092e-02 | 1.155 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 6.995092e-02 | 1.155 |
| R-HSA-9748787 | Azathioprine ADME | 7.305873e-02 | 1.136 |
| R-HSA-209563 | Axonal growth stimulation | 7.957217e-02 | 1.099 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 7.957217e-02 | 1.099 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.242539e-01 | 0.906 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.242539e-01 | 0.906 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.528344e-01 | 0.816 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.528344e-01 | 0.816 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.528344e-01 | 0.816 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.667743e-01 | 0.778 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.804856e-01 | 0.744 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.939721e-01 | 0.712 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.072375e-01 | 0.684 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.207355e-01 | 0.918 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.262145e-01 | 0.899 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.262145e-01 | 0.899 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.373432e-01 | 0.862 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.373432e-01 | 0.862 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.429862e-01 | 0.845 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 8.206559e-02 | 1.086 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.544138e-01 | 0.811 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 9.152487e-02 | 1.038 |
| R-HSA-6782135 | Dual incision in TC-NER | 9.807104e-02 | 1.008 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.777513e-01 | 0.750 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.836698e-01 | 0.736 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.152247e-01 | 0.938 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.152247e-01 | 0.938 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.525205e-01 | 0.817 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.525205e-01 | 0.817 |
| R-HSA-380287 | Centrosome maturation | 1.603945e-01 | 0.795 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.403408e-01 | 0.853 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.888573e-01 | 0.724 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.184896e-01 | 0.661 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.447749e-01 | 0.839 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.447749e-01 | 0.839 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.334133e-01 | 0.875 |
| R-HSA-4641258 | Degradation of DVL | 1.660099e-01 | 0.780 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.174061e-01 | 0.930 |
| R-HSA-156902 | Peptide chain elongation | 2.184896e-01 | 0.661 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.013455e-01 | 0.994 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.262145e-01 | 0.899 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.603945e-01 | 0.795 |
| R-HSA-72172 | mRNA Splicing | 8.163182e-02 | 1.088 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.804856e-01 | 0.744 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.660099e-01 | 0.780 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.955891e-01 | 0.709 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 9.947076e-02 | 1.002 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 1.242539e-01 | 0.906 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 9.947076e-02 | 1.002 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.713048e-01 | 0.766 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.713048e-01 | 0.766 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.039432e-01 | 0.983 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.316041e-01 | 0.881 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 7.957217e-02 | 1.099 |
| R-HSA-9636569 | Suppression of autophagy | 1.096054e-01 | 0.960 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 1.528344e-01 | 0.816 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.804856e-01 | 0.744 |
| R-HSA-68952 | DNA replication initiation | 1.939721e-01 | 0.712 |
| R-HSA-350054 | Notch-HLH transcription pathway | 7.943016e-02 | 1.100 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.046820e-01 | 0.980 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.486775e-01 | 0.828 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.660099e-01 | 0.780 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.196896e-01 | 0.658 |
| R-HSA-9646399 | Aggrephagy | 1.836698e-01 | 0.736 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.315286e-01 | 0.881 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.018266e-01 | 0.992 |
| R-HSA-9711097 | Cellular response to starvation | 1.702119e-01 | 0.769 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.067920e-01 | 0.684 |
| R-HSA-390696 | Adrenoceptors | 1.667743e-01 | 0.778 |
| R-HSA-180024 | DARPP-32 events | 1.153181e-01 | 0.938 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 7.943016e-02 | 1.100 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.429862e-01 | 0.845 |
| R-HSA-3371571 | HSF1-dependent transactivation | 7.600937e-02 | 1.119 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 1.486775e-01 | 0.828 |
| R-HSA-4086398 | Ca2+ pathway | 1.525205e-01 | 0.817 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.836698e-01 | 0.736 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.836698e-01 | 0.736 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.201536e-01 | 0.920 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.667743e-01 | 0.778 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 1.667743e-01 | 0.778 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.939721e-01 | 0.712 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 7.943016e-02 | 1.100 |
| R-HSA-77387 | Insulin receptor recycling | 1.099656e-01 | 0.959 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.207355e-01 | 0.918 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.373432e-01 | 0.862 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.015851e-01 | 0.696 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.128442e-01 | 0.948 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.244105e-01 | 0.905 |
| R-HSA-167172 | Transcription of the HIV genome | 1.334133e-01 | 0.875 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.477454e-02 | 1.023 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.201536e-01 | 0.920 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.046820e-01 | 0.980 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.486775e-01 | 0.828 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.117075e-01 | 0.952 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.621584e-01 | 0.790 |
| R-HSA-9658195 | Leishmania infection | 1.304337e-01 | 0.885 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.304337e-01 | 0.885 |
| R-HSA-111933 | Calmodulin induced events | 1.601922e-01 | 0.795 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.896166e-01 | 0.722 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.528344e-01 | 0.816 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.939721e-01 | 0.712 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.939721e-01 | 0.712 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.046820e-01 | 0.980 |
| R-HSA-111997 | CaM pathway | 1.601922e-01 | 0.795 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.836698e-01 | 0.736 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.896166e-01 | 0.722 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.896166e-01 | 0.722 |
| R-HSA-111996 | Ca-dependent events | 2.015851e-01 | 0.696 |
| R-HSA-983189 | Kinesins | 1.048010e-01 | 0.980 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.196896e-01 | 0.658 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.601922e-01 | 0.795 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.588896e-01 | 0.799 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.242539e-01 | 0.906 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 1.242539e-01 | 0.906 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 1.242539e-01 | 0.906 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 1.242539e-01 | 0.906 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.528344e-01 | 0.816 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.804856e-01 | 0.744 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.804856e-01 | 0.744 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.048010e-01 | 0.980 |
| R-HSA-3371568 | Attenuation phase | 1.836698e-01 | 0.736 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 1.955891e-01 | 0.709 |
| R-HSA-190828 | Gap junction trafficking | 2.136376e-01 | 0.670 |
| R-HSA-8953854 | Metabolism of RNA | 1.811003e-01 | 0.742 |
| R-HSA-1266695 | Interleukin-7 signaling | 9.433594e-02 | 1.025 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.185391e-01 | 0.660 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 1.544138e-01 | 0.811 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.724299e-01 | 0.763 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.196896e-01 | 0.658 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.804856e-01 | 0.744 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.804856e-01 | 0.744 |
| R-HSA-5689877 | Josephin domain DUBs | 1.939721e-01 | 0.712 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.777513e-01 | 0.750 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.015851e-01 | 0.696 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.901192e-02 | 1.102 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.939721e-01 | 0.712 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 7.943016e-02 | 1.100 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 9.947076e-02 | 1.002 |
| R-HSA-9659379 | Sensory processing of sound | 1.764978e-01 | 0.753 |
| R-HSA-392499 | Metabolism of proteins | 8.279447e-02 | 1.082 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.429862e-01 | 0.845 |
| R-HSA-69239 | Synthesis of DNA | 1.373774e-01 | 0.862 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.667743e-01 | 0.778 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.660099e-01 | 0.780 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.896166e-01 | 0.722 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.334133e-01 | 0.875 |
| R-HSA-168255 | Influenza Infection | 1.138164e-01 | 0.944 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.048010e-01 | 0.980 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 9.152487e-02 | 1.038 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.955891e-01 | 0.709 |
| R-HSA-191273 | Cholesterol biosynthesis | 1.724299e-01 | 0.763 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.667743e-01 | 0.778 |
| R-HSA-1643685 | Disease | 1.608561e-01 | 0.794 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.048010e-01 | 0.980 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.048010e-01 | 0.980 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.048010e-01 | 0.980 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.048010e-01 | 0.980 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.486312e-01 | 0.828 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.014314e-01 | 0.696 |
| R-HSA-9755088 | Ribavirin ADME | 7.464182e-02 | 1.127 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.660099e-01 | 0.780 |
| R-HSA-983712 | Ion channel transport | 1.343865e-01 | 0.872 |
| R-HSA-1474244 | Extracellular matrix organization | 1.323929e-01 | 0.878 |
| R-HSA-9675108 | Nervous system development | 2.046169e-01 | 0.689 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 9.433594e-02 | 1.025 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.681059e-01 | 0.774 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.207355e-01 | 0.918 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.373432e-01 | 0.862 |
| R-HSA-194138 | Signaling by VEGF | 2.043895e-01 | 0.690 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.869184e-01 | 0.728 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 1.096054e-01 | 0.960 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.955891e-01 | 0.709 |
| R-HSA-381070 | IRE1alpha activates chaperones | 8.882275e-02 | 1.051 |
| R-HSA-168256 | Immune System | 1.992731e-01 | 0.701 |
| R-HSA-2682334 | EPH-Ephrin signaling | 9.126414e-02 | 1.040 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.643773e-01 | 0.784 |
| R-HSA-8957322 | Metabolism of steroids | 2.145107e-01 | 0.669 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.136376e-01 | 0.670 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.099216e-01 | 0.678 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.136376e-01 | 0.670 |
| R-HSA-201556 | Signaling by ALK | 1.777513e-01 | 0.750 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.202854e-01 | 0.657 |
| R-HSA-199991 | Membrane Trafficking | 2.234926e-01 | 0.651 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.257560e-01 | 0.646 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.257560e-01 | 0.646 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.271286e-01 | 0.644 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.314726e-01 | 0.636 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.318345e-01 | 0.635 |
| R-HSA-437239 | Recycling pathway of L1 | 2.318345e-01 | 0.635 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.318345e-01 | 0.635 |
| R-HSA-422475 | Axon guidance | 2.327696e-01 | 0.633 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.331193e-01 | 0.632 |
| R-HSA-5619094 | Variant SLC6A14 may confer susceptibility towards obesity | 2.331193e-01 | 0.632 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.331193e-01 | 0.632 |
| R-HSA-4641265 | Repression of WNT target genes | 2.331193e-01 | 0.632 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.331193e-01 | 0.632 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.331193e-01 | 0.632 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.331193e-01 | 0.632 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.331193e-01 | 0.632 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.331193e-01 | 0.632 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.331193e-01 | 0.632 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.358318e-01 | 0.627 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.379232e-01 | 0.624 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.402055e-01 | 0.619 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.440200e-01 | 0.613 |
| R-HSA-73893 | DNA Damage Bypass | 2.440200e-01 | 0.613 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.440200e-01 | 0.613 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.440200e-01 | 0.613 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2.457428e-01 | 0.610 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.457428e-01 | 0.610 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.457428e-01 | 0.610 |
| R-HSA-163685 | Integration of energy metabolism | 2.498517e-01 | 0.602 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.534051e-01 | 0.596 |
| R-HSA-69275 | G2/M Transition | 2.549225e-01 | 0.594 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.561649e-01 | 0.591 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.562308e-01 | 0.591 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.578285e-01 | 0.589 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.578285e-01 | 0.589 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.581592e-01 | 0.588 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.581592e-01 | 0.588 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.581592e-01 | 0.588 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.581592e-01 | 0.588 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.581592e-01 | 0.588 |
| R-HSA-8963896 | HDL assembly | 2.581592e-01 | 0.588 |
| R-HSA-435354 | Zinc transporters | 2.581592e-01 | 0.588 |
| R-HSA-6807070 | PTEN Regulation | 2.606457e-01 | 0.584 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.611304e-01 | 0.583 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.611304e-01 | 0.583 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.622624e-01 | 0.581 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.623410e-01 | 0.581 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.642641e-01 | 0.578 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.642641e-01 | 0.578 |
| R-HSA-9664407 | Parasite infection | 2.642641e-01 | 0.578 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.663363e-01 | 0.575 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.684521e-01 | 0.571 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.684521e-01 | 0.571 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.684521e-01 | 0.571 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.703720e-01 | 0.568 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.703720e-01 | 0.568 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.703720e-01 | 0.568 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.703720e-01 | 0.568 |
| R-HSA-416700 | Other semaphorin interactions | 2.703720e-01 | 0.568 |
| R-HSA-8876725 | Protein methylation | 2.703720e-01 | 0.568 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.800875e-01 | 0.553 |
| R-HSA-70171 | Glycolysis | 2.800875e-01 | 0.553 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.806705e-01 | 0.552 |
| R-HSA-9753281 | Paracetamol ADME | 2.806705e-01 | 0.552 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.823845e-01 | 0.549 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.823845e-01 | 0.549 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 2.823845e-01 | 0.549 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.823845e-01 | 0.549 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.823845e-01 | 0.549 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.823845e-01 | 0.549 |
| R-HSA-9664420 | Killing mechanisms | 2.823845e-01 | 0.549 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.823845e-01 | 0.549 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.823845e-01 | 0.549 |
| R-HSA-9678110 | Attachment and Entry | 2.823845e-01 | 0.549 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.823845e-01 | 0.549 |
| R-HSA-168268 | Virus Assembly and Release | 2.823845e-01 | 0.549 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.845625e-01 | 0.546 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.867745e-01 | 0.542 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.867745e-01 | 0.542 |
| R-HSA-177929 | Signaling by EGFR | 2.867745e-01 | 0.542 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.867745e-01 | 0.542 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.928731e-01 | 0.533 |
| R-HSA-192823 | Viral mRNA Translation | 2.935298e-01 | 0.532 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.941999e-01 | 0.531 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 2.941999e-01 | 0.531 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.941999e-01 | 0.531 |
| R-HSA-69242 | S Phase | 2.972061e-01 | 0.527 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.980208e-01 | 0.526 |
| R-HSA-111885 | Opioid Signalling | 2.980208e-01 | 0.526 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.024313e-01 | 0.519 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.050480e-01 | 0.516 |
| R-HSA-191859 | snRNP Assembly | 3.050480e-01 | 0.516 |
| R-HSA-180786 | Extension of Telomeres | 3.050480e-01 | 0.516 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 3.058215e-01 | 0.515 |
| R-HSA-2028269 | Signaling by Hippo | 3.058215e-01 | 0.515 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.058215e-01 | 0.515 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.058215e-01 | 0.515 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.058215e-01 | 0.515 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.086698e-01 | 0.511 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.160176e-01 | 0.500 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.171841e-01 | 0.499 |
| R-HSA-112043 | PLC beta mediated events | 3.171841e-01 | 0.499 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.172525e-01 | 0.499 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.172525e-01 | 0.499 |
| R-HSA-163615 | PKA activation | 3.172525e-01 | 0.499 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.172525e-01 | 0.499 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.172525e-01 | 0.499 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.172525e-01 | 0.499 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.194467e-01 | 0.496 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.205216e-01 | 0.494 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.205216e-01 | 0.494 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.232343e-01 | 0.490 |
| R-HSA-9612973 | Autophagy | 3.268921e-01 | 0.486 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.284959e-01 | 0.483 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.284959e-01 | 0.483 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.284959e-01 | 0.483 |
| R-HSA-392517 | Rap1 signalling | 3.284959e-01 | 0.483 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.284959e-01 | 0.483 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.297522e-01 | 0.482 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.385385e-01 | 0.470 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.385385e-01 | 0.470 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.385385e-01 | 0.470 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.395548e-01 | 0.469 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.395548e-01 | 0.469 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.395548e-01 | 0.469 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.395548e-01 | 0.469 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.395548e-01 | 0.469 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.395548e-01 | 0.469 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.410294e-01 | 0.467 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.504323e-01 | 0.455 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.504323e-01 | 0.455 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 3.504323e-01 | 0.455 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.504323e-01 | 0.455 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.532589e-01 | 0.452 |
| R-HSA-112040 | G-protein mediated events | 3.532589e-01 | 0.452 |
| R-HSA-913709 | O-linked glycosylation of mucins | 3.592108e-01 | 0.445 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.611313e-01 | 0.442 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.611313e-01 | 0.442 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.611313e-01 | 0.442 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.611313e-01 | 0.442 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.611313e-01 | 0.442 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.611313e-01 | 0.442 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.611313e-01 | 0.442 |
| R-HSA-9694614 | Attachment and Entry | 3.611313e-01 | 0.442 |
| R-HSA-373760 | L1CAM interactions | 3.654996e-01 | 0.437 |
| R-HSA-70326 | Glucose metabolism | 3.699784e-01 | 0.432 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.710535e-01 | 0.431 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.716547e-01 | 0.430 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.716547e-01 | 0.430 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 3.716547e-01 | 0.430 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.716547e-01 | 0.430 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 3.769424e-01 | 0.424 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.769424e-01 | 0.424 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.820054e-01 | 0.418 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 3.820054e-01 | 0.418 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.820054e-01 | 0.418 |
| R-HSA-200425 | Carnitine shuttle | 3.820054e-01 | 0.418 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.820054e-01 | 0.418 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.828085e-01 | 0.417 |
| R-HSA-72306 | tRNA processing | 3.828821e-01 | 0.417 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.886510e-01 | 0.410 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.886510e-01 | 0.410 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.921862e-01 | 0.407 |
| R-HSA-429947 | Deadenylation of mRNA | 3.921862e-01 | 0.407 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.921862e-01 | 0.407 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.921862e-01 | 0.407 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.940535e-01 | 0.404 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.944690e-01 | 0.404 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 3.944690e-01 | 0.404 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.967148e-01 | 0.402 |
| R-HSA-917937 | Iron uptake and transport | 4.002618e-01 | 0.398 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.011436e-01 | 0.397 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.022000e-01 | 0.396 |
| R-HSA-3000157 | Laminin interactions | 4.022000e-01 | 0.396 |
| R-HSA-9620244 | Long-term potentiation | 4.022000e-01 | 0.396 |
| R-HSA-9839394 | TGFBR3 expression | 4.022000e-01 | 0.396 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.022000e-01 | 0.396 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.058961e-01 | 0.392 |
| R-HSA-5689603 | UCH proteinases | 4.060286e-01 | 0.391 |
| R-HSA-72312 | rRNA processing | 4.062329e-01 | 0.391 |
| R-HSA-69206 | G1/S Transition | 4.099736e-01 | 0.387 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.120493e-01 | 0.385 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.120493e-01 | 0.385 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.120493e-01 | 0.385 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 4.120493e-01 | 0.385 |
| R-HSA-3295583 | TRP channels | 4.120493e-01 | 0.385 |
| R-HSA-9845614 | Sphingolipid catabolism | 4.120493e-01 | 0.385 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.120493e-01 | 0.385 |
| R-HSA-4086400 | PCP/CE pathway | 4.174816e-01 | 0.379 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.174816e-01 | 0.379 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.217370e-01 | 0.375 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.263997e-01 | 0.370 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.312657e-01 | 0.365 |
| R-HSA-622312 | Inflammasomes | 4.312657e-01 | 0.365 |
| R-HSA-9843745 | Adipogenesis | 4.405443e-01 | 0.356 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.406379e-01 | 0.356 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.406379e-01 | 0.356 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.406379e-01 | 0.356 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.406379e-01 | 0.356 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.406379e-01 | 0.356 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.448638e-01 | 0.352 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.491701e-01 | 0.348 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.498562e-01 | 0.347 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.498562e-01 | 0.347 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.511489e-01 | 0.346 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.566534e-01 | 0.340 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.589232e-01 | 0.338 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.589232e-01 | 0.338 |
| R-HSA-1538133 | G0 and Early G1 | 4.678413e-01 | 0.330 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.678413e-01 | 0.330 |
| R-HSA-8931838 | DAG1 glycosylations | 4.678413e-01 | 0.330 |
| R-HSA-69190 | DNA strand elongation | 4.678413e-01 | 0.330 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.678413e-01 | 0.330 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.678413e-01 | 0.330 |
| R-HSA-5173105 | O-linked glycosylation | 4.704937e-01 | 0.327 |
| R-HSA-72766 | Translation | 4.706490e-01 | 0.327 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.729741e-01 | 0.325 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.747144e-01 | 0.324 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.766129e-01 | 0.322 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.766129e-01 | 0.322 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.766129e-01 | 0.322 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.766129e-01 | 0.322 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.766129e-01 | 0.322 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.766129e-01 | 0.322 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.766129e-01 | 0.322 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.766129e-01 | 0.322 |
| R-HSA-9663891 | Selective autophagy | 4.783487e-01 | 0.320 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.852405e-01 | 0.314 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.852405e-01 | 0.314 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.852405e-01 | 0.314 |
| R-HSA-9679506 | SARS-CoV Infections | 4.860301e-01 | 0.313 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.889972e-01 | 0.311 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.937264e-01 | 0.307 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.937264e-01 | 0.307 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.937264e-01 | 0.307 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.937264e-01 | 0.307 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.937264e-01 | 0.307 |
| R-HSA-5673000 | RAF activation | 4.937264e-01 | 0.307 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.955817e-01 | 0.305 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.020730e-01 | 0.299 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.020730e-01 | 0.299 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.020730e-01 | 0.299 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.020730e-01 | 0.299 |
| R-HSA-381042 | PERK regulates gene expression | 5.020730e-01 | 0.299 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 5.020730e-01 | 0.299 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.047129e-01 | 0.297 |
| R-HSA-913531 | Interferon Signaling | 5.058638e-01 | 0.296 |
| R-HSA-163560 | Triglyceride catabolism | 5.102824e-01 | 0.292 |
| R-HSA-8853659 | RET signaling | 5.102824e-01 | 0.292 |
| R-HSA-69205 | G1/S-Specific Transcription | 5.102824e-01 | 0.292 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.119753e-01 | 0.291 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.160300e-01 | 0.287 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.183570e-01 | 0.285 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.262989e-01 | 0.279 |
| R-HSA-9931953 | Biofilm formation | 5.262989e-01 | 0.279 |
| R-HSA-8875878 | MET promotes cell motility | 5.262989e-01 | 0.279 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.320666e-01 | 0.274 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.341104e-01 | 0.272 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.351919e-01 | 0.271 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.351919e-01 | 0.271 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.360293e-01 | 0.271 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.417935e-01 | 0.266 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.450629e-01 | 0.264 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.493504e-01 | 0.260 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.493504e-01 | 0.260 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.493504e-01 | 0.260 |
| R-HSA-9607240 | FLT3 Signaling | 5.493504e-01 | 0.260 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.567831e-01 | 0.254 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.567831e-01 | 0.254 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.567831e-01 | 0.254 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.567831e-01 | 0.254 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.567831e-01 | 0.254 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.567831e-01 | 0.254 |
| R-HSA-9748784 | Drug ADME | 5.573487e-01 | 0.254 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.640936e-01 | 0.249 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.640936e-01 | 0.249 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.670322e-01 | 0.246 |
| R-HSA-8951664 | Neddylation | 5.672103e-01 | 0.246 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.690973e-01 | 0.245 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.712841e-01 | 0.243 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.712841e-01 | 0.243 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.712841e-01 | 0.243 |
| R-HSA-375280 | Amine ligand-binding receptors | 5.783563e-01 | 0.238 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.783563e-01 | 0.238 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.820520e-01 | 0.235 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.853124e-01 | 0.233 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.853124e-01 | 0.233 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.853124e-01 | 0.233 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.897433e-01 | 0.229 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.921540e-01 | 0.228 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.921540e-01 | 0.228 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.921540e-01 | 0.228 |
| R-HSA-9675135 | Diseases of DNA repair | 5.921540e-01 | 0.228 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.921540e-01 | 0.228 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.921540e-01 | 0.228 |
| R-HSA-75153 | Apoptotic execution phase | 5.921540e-01 | 0.228 |
| R-HSA-5619102 | SLC transporter disorders | 5.930992e-01 | 0.227 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.988833e-01 | 0.223 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.997386e-01 | 0.222 |
| R-HSA-9634597 | GPER1 signaling | 6.055019e-01 | 0.218 |
| R-HSA-425410 | Metal ion SLC transporters | 6.055019e-01 | 0.218 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.110884e-01 | 0.214 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.181342e-01 | 0.209 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.181342e-01 | 0.209 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.184145e-01 | 0.209 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.187000e-01 | 0.209 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.247120e-01 | 0.204 |
| R-HSA-72187 | mRNA 3'-end processing | 6.309059e-01 | 0.200 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.309059e-01 | 0.200 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.309059e-01 | 0.200 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.309059e-01 | 0.200 |
| R-HSA-72649 | Translation initiation complex formation | 6.429899e-01 | 0.192 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.429899e-01 | 0.192 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.429899e-01 | 0.192 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.473117e-01 | 0.189 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.488833e-01 | 0.188 |
| R-HSA-418597 | G alpha (z) signalling events | 6.488833e-01 | 0.188 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.546798e-01 | 0.184 |
| R-HSA-5578775 | Ion homeostasis | 6.546798e-01 | 0.184 |
| R-HSA-75893 | TNF signaling | 6.546798e-01 | 0.184 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.546798e-01 | 0.184 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.559373e-01 | 0.183 |
| R-HSA-5621480 | Dectin-2 family | 6.603809e-01 | 0.180 |
| R-HSA-1483166 | Synthesis of PA | 6.603809e-01 | 0.180 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.621537e-01 | 0.179 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.659882e-01 | 0.177 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.659882e-01 | 0.177 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.659882e-01 | 0.177 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.715033e-01 | 0.173 |
| R-HSA-8979227 | Triglyceride metabolism | 6.715033e-01 | 0.173 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.715033e-01 | 0.173 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.735830e-01 | 0.172 |
| R-HSA-5617833 | Cilium Assembly | 6.744984e-01 | 0.171 |
| R-HSA-379724 | tRNA Aminoacylation | 6.769277e-01 | 0.169 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.807116e-01 | 0.167 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.822628e-01 | 0.166 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.822628e-01 | 0.166 |
| R-HSA-1442490 | Collagen degradation | 6.822628e-01 | 0.166 |
| R-HSA-114608 | Platelet degranulation | 6.828538e-01 | 0.166 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.875102e-01 | 0.163 |
| R-HSA-186797 | Signaling by PDGF | 6.875102e-01 | 0.163 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.977473e-01 | 0.156 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.977473e-01 | 0.156 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.076502e-01 | 0.150 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.104612e-01 | 0.148 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 7.124798e-01 | 0.147 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 7.219018e-01 | 0.142 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.249756e-01 | 0.140 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.264968e-01 | 0.139 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.264968e-01 | 0.139 |
| R-HSA-3000178 | ECM proteoglycans | 7.310161e-01 | 0.136 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.336222e-01 | 0.135 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.339741e-01 | 0.134 |
| R-HSA-1632852 | Macroautophagy | 7.379300e-01 | 0.132 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.386677e-01 | 0.132 |
| R-HSA-9749641 | Aspirin ADME | 7.398328e-01 | 0.131 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.441326e-01 | 0.128 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.441326e-01 | 0.128 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.566118e-01 | 0.121 |
| R-HSA-5619084 | ABC transporter disorders | 7.606353e-01 | 0.119 |
| R-HSA-216083 | Integrin cell surface interactions | 7.606353e-01 | 0.119 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.680600e-01 | 0.115 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.684845e-01 | 0.114 |
| R-HSA-6806834 | Signaling by MET | 7.684845e-01 | 0.114 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.737130e-01 | 0.111 |
| R-HSA-109582 | Hemostasis | 7.837325e-01 | 0.106 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.899577e-01 | 0.102 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.905266e-01 | 0.102 |
| R-HSA-877300 | Interferon gamma signaling | 7.925633e-01 | 0.101 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.973990e-01 | 0.098 |
| R-HSA-15869 | Metabolism of nucleotides | 7.979208e-01 | 0.098 |
| R-HSA-109581 | Apoptosis | 8.002104e-01 | 0.097 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.040468e-01 | 0.095 |
| R-HSA-6798695 | Neutrophil degranulation | 8.059936e-01 | 0.094 |
| R-HSA-391251 | Protein folding | 8.166974e-01 | 0.088 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.166974e-01 | 0.088 |
| R-HSA-112316 | Neuronal System | 8.226561e-01 | 0.085 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.227141e-01 | 0.085 |
| R-HSA-418555 | G alpha (s) signalling events | 8.239283e-01 | 0.084 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.256483e-01 | 0.083 |
| R-HSA-5389840 | Mitochondrial translation elongation | 8.313723e-01 | 0.080 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.313723e-01 | 0.080 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.313723e-01 | 0.080 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.326883e-01 | 0.080 |
| R-HSA-5368286 | Mitochondrial translation initiation | 8.369091e-01 | 0.077 |
| R-HSA-422356 | Regulation of insulin secretion | 8.369091e-01 | 0.077 |
| R-HSA-418594 | G alpha (i) signalling events | 8.392708e-01 | 0.076 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.422647e-01 | 0.075 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 8.499714e-01 | 0.071 |
| R-HSA-3781865 | Diseases of glycosylation | 8.509797e-01 | 0.070 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.524560e-01 | 0.069 |
| R-HSA-9833110 | RSV-host interactions | 8.548996e-01 | 0.068 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.574969e-01 | 0.067 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.596665e-01 | 0.066 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.598762e-01 | 0.066 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.642774e-01 | 0.063 |
| R-HSA-5419276 | Mitochondrial translation termination | 8.665259e-01 | 0.062 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.667865e-01 | 0.062 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.687373e-01 | 0.061 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.812598e-01 | 0.055 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.832280e-01 | 0.054 |
| R-HSA-5357801 | Programmed Cell Death | 8.882845e-01 | 0.051 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.889395e-01 | 0.051 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.943727e-01 | 0.048 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.978469e-01 | 0.047 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.995410e-01 | 0.046 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.044574e-01 | 0.044 |
| R-HSA-382551 | Transport of small molecules | 9.078378e-01 | 0.042 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.106416e-01 | 0.041 |
| R-HSA-449147 | Signaling by Interleukins | 9.131608e-01 | 0.039 |
| R-HSA-5576891 | Cardiac conduction | 9.135825e-01 | 0.039 |
| R-HSA-388396 | GPCR downstream signalling | 9.137660e-01 | 0.039 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.201030e-01 | 0.036 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.219353e-01 | 0.035 |
| R-HSA-5368287 | Mitochondrial translation | 9.244127e-01 | 0.034 |
| R-HSA-9758941 | Gastrulation | 9.381749e-01 | 0.028 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.412059e-01 | 0.026 |
| R-HSA-2142753 | Arachidonate metabolism | 9.412059e-01 | 0.026 |
| R-HSA-168249 | Innate Immune System | 9.416941e-01 | 0.026 |
| R-HSA-372790 | Signaling by GPCR | 9.572641e-01 | 0.019 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.588244e-01 | 0.018 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.674974e-01 | 0.014 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.699491e-01 | 0.013 |
| R-HSA-428157 | Sphingolipid metabolism | 9.745977e-01 | 0.011 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.754376e-01 | 0.011 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.754376e-01 | 0.011 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.754376e-01 | 0.011 |
| R-HSA-6805567 | Keratinization | 9.770353e-01 | 0.010 |
| R-HSA-5668914 | Diseases of metabolism | 9.798233e-01 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.860441e-01 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.880408e-01 | 0.005 |
| R-HSA-416476 | G alpha (q) signalling events | 9.913566e-01 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.927629e-01 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 9.937645e-01 | 0.003 |
| R-HSA-1483257 | Phospholipid metabolism | 9.948805e-01 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.985339e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.989302e-01 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.990615e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.990769e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999667e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.875 | 0.184 | 2 | 0.872 |
RSK2 |
0.870 | 0.252 | -3 | 0.817 |
PRKD1 |
0.869 | 0.246 | -3 | 0.825 |
CDC7 |
0.868 | 0.082 | 1 | 0.862 |
PIM3 |
0.867 | 0.200 | -3 | 0.851 |
CAMK1B |
0.867 | 0.198 | -3 | 0.878 |
PRKD2 |
0.867 | 0.245 | -3 | 0.796 |
CLK3 |
0.866 | 0.211 | 1 | 0.811 |
P90RSK |
0.865 | 0.217 | -3 | 0.817 |
NDR2 |
0.863 | 0.129 | -3 | 0.846 |
PIM1 |
0.863 | 0.249 | -3 | 0.814 |
MAPKAPK2 |
0.862 | 0.216 | -3 | 0.766 |
MOS |
0.862 | 0.082 | 1 | 0.876 |
PRPK |
0.860 | -0.072 | -1 | 0.847 |
CAMK2B |
0.860 | 0.225 | 2 | 0.776 |
CAMK2G |
0.860 | 0.040 | 2 | 0.798 |
SKMLCK |
0.859 | 0.194 | -2 | 0.882 |
DSTYK |
0.859 | 0.035 | 2 | 0.874 |
PKN3 |
0.859 | 0.136 | -3 | 0.839 |
MAPKAPK3 |
0.858 | 0.162 | -3 | 0.789 |
RAF1 |
0.858 | -0.001 | 1 | 0.834 |
IKKB |
0.858 | -0.039 | -2 | 0.752 |
CAMK2D |
0.858 | 0.142 | -3 | 0.839 |
CAMLCK |
0.858 | 0.172 | -2 | 0.883 |
P70S6KB |
0.858 | 0.186 | -3 | 0.826 |
MTOR |
0.857 | -0.049 | 1 | 0.787 |
ATR |
0.857 | 0.048 | 1 | 0.836 |
PDHK4 |
0.857 | -0.157 | 1 | 0.843 |
GRK6 |
0.857 | 0.127 | 1 | 0.851 |
RSK3 |
0.857 | 0.171 | -3 | 0.809 |
DAPK2 |
0.856 | 0.179 | -3 | 0.874 |
CDKL1 |
0.856 | 0.116 | -3 | 0.842 |
NDR1 |
0.856 | 0.127 | -3 | 0.844 |
NUAK2 |
0.855 | 0.111 | -3 | 0.857 |
GCN2 |
0.855 | -0.118 | 2 | 0.790 |
NLK |
0.855 | 0.029 | 1 | 0.812 |
ERK5 |
0.853 | 0.034 | 1 | 0.768 |
TBK1 |
0.853 | -0.074 | 1 | 0.734 |
MSK1 |
0.853 | 0.216 | -3 | 0.782 |
BMPR2 |
0.853 | -0.124 | -2 | 0.878 |
CAMK2A |
0.852 | 0.178 | 2 | 0.774 |
RSK4 |
0.852 | 0.226 | -3 | 0.794 |
NIK |
0.852 | 0.070 | -3 | 0.871 |
CAMK4 |
0.852 | 0.117 | -3 | 0.828 |
SRPK1 |
0.852 | 0.145 | -3 | 0.798 |
IKKE |
0.851 | -0.074 | 1 | 0.728 |
GRK1 |
0.851 | 0.092 | -2 | 0.757 |
MSK2 |
0.851 | 0.160 | -3 | 0.784 |
PDHK1 |
0.851 | -0.149 | 1 | 0.826 |
RIPK3 |
0.851 | 0.000 | 3 | 0.777 |
PKACG |
0.851 | 0.143 | -2 | 0.795 |
AMPKA1 |
0.850 | 0.097 | -3 | 0.849 |
AURC |
0.850 | 0.172 | -2 | 0.724 |
PKN2 |
0.850 | 0.092 | -3 | 0.836 |
WNK1 |
0.850 | 0.035 | -2 | 0.887 |
LATS2 |
0.850 | 0.055 | -5 | 0.721 |
FAM20C |
0.850 | 0.148 | 2 | 0.647 |
ATM |
0.849 | 0.079 | 1 | 0.786 |
TSSK2 |
0.849 | 0.102 | -5 | 0.853 |
ULK2 |
0.848 | -0.147 | 2 | 0.790 |
HUNK |
0.848 | -0.034 | 2 | 0.834 |
GRK5 |
0.848 | -0.074 | -3 | 0.822 |
CDKL5 |
0.848 | 0.081 | -3 | 0.834 |
PRKD3 |
0.847 | 0.166 | -3 | 0.782 |
HIPK4 |
0.847 | 0.068 | 1 | 0.758 |
MYLK4 |
0.847 | 0.179 | -2 | 0.823 |
MST4 |
0.847 | 0.036 | 2 | 0.828 |
TGFBR2 |
0.847 | -0.029 | -2 | 0.785 |
CLK4 |
0.847 | 0.188 | -3 | 0.807 |
PKACB |
0.847 | 0.216 | -2 | 0.744 |
CLK2 |
0.847 | 0.260 | -3 | 0.790 |
MARK4 |
0.846 | 0.016 | 4 | 0.778 |
ICK |
0.846 | 0.084 | -3 | 0.863 |
TSSK1 |
0.846 | 0.101 | -3 | 0.862 |
NEK6 |
0.846 | -0.064 | -2 | 0.864 |
PKCD |
0.846 | 0.092 | 2 | 0.766 |
AMPKA2 |
0.846 | 0.102 | -3 | 0.829 |
IKKA |
0.846 | -0.004 | -2 | 0.730 |
BCKDK |
0.845 | -0.067 | -1 | 0.861 |
PRKX |
0.845 | 0.242 | -3 | 0.724 |
NEK7 |
0.845 | -0.137 | -3 | 0.819 |
TGFBR1 |
0.845 | 0.088 | -2 | 0.774 |
KIS |
0.844 | 0.042 | 1 | 0.672 |
NIM1 |
0.844 | 0.040 | 3 | 0.804 |
AURB |
0.844 | 0.155 | -2 | 0.720 |
CLK1 |
0.844 | 0.177 | -3 | 0.789 |
LATS1 |
0.844 | 0.139 | -3 | 0.861 |
BMPR1B |
0.844 | 0.128 | 1 | 0.822 |
PLK1 |
0.844 | 0.065 | -2 | 0.817 |
SRPK2 |
0.843 | 0.136 | -3 | 0.737 |
PAK1 |
0.843 | 0.108 | -2 | 0.816 |
GRK4 |
0.843 | -0.049 | -2 | 0.792 |
AURA |
0.843 | 0.152 | -2 | 0.689 |
MELK |
0.842 | 0.107 | -3 | 0.812 |
MASTL |
0.842 | -0.165 | -2 | 0.820 |
ALK4 |
0.842 | 0.037 | -2 | 0.799 |
AKT2 |
0.842 | 0.190 | -3 | 0.745 |
CHK1 |
0.841 | 0.123 | -3 | 0.828 |
DNAPK |
0.841 | 0.118 | 1 | 0.727 |
PAK6 |
0.841 | 0.133 | -2 | 0.764 |
NUAK1 |
0.841 | 0.073 | -3 | 0.818 |
RIPK1 |
0.841 | -0.077 | 1 | 0.797 |
DYRK2 |
0.840 | 0.081 | 1 | 0.678 |
MLK1 |
0.840 | -0.150 | 2 | 0.796 |
DLK |
0.840 | -0.081 | 1 | 0.832 |
ULK1 |
0.840 | -0.169 | -3 | 0.790 |
CHAK2 |
0.839 | -0.088 | -1 | 0.807 |
ANKRD3 |
0.839 | -0.084 | 1 | 0.848 |
PLK3 |
0.839 | 0.063 | 2 | 0.776 |
NEK9 |
0.839 | -0.115 | 2 | 0.825 |
PIM2 |
0.839 | 0.187 | -3 | 0.788 |
MNK2 |
0.839 | 0.088 | -2 | 0.842 |
ALK2 |
0.839 | 0.088 | -2 | 0.791 |
WNK3 |
0.838 | -0.183 | 1 | 0.798 |
SGK3 |
0.838 | 0.171 | -3 | 0.781 |
PKG2 |
0.838 | 0.148 | -2 | 0.739 |
CAMK1G |
0.838 | 0.119 | -3 | 0.800 |
PAK3 |
0.838 | 0.054 | -2 | 0.823 |
SRPK3 |
0.838 | 0.095 | -3 | 0.778 |
QSK |
0.837 | 0.068 | 4 | 0.743 |
DRAK1 |
0.836 | 0.091 | 1 | 0.823 |
GRK7 |
0.836 | 0.069 | 1 | 0.788 |
ACVR2B |
0.836 | 0.061 | -2 | 0.780 |
MAPKAPK5 |
0.836 | 0.057 | -3 | 0.749 |
SIK |
0.836 | 0.079 | -3 | 0.786 |
ACVR2A |
0.836 | 0.047 | -2 | 0.770 |
JNK2 |
0.835 | 0.080 | 1 | 0.608 |
PKACA |
0.835 | 0.195 | -2 | 0.699 |
PKR |
0.835 | -0.002 | 1 | 0.813 |
PAK2 |
0.835 | 0.062 | -2 | 0.802 |
QIK |
0.834 | -0.018 | -3 | 0.834 |
CDK8 |
0.834 | -0.021 | 1 | 0.661 |
SMG1 |
0.834 | 0.018 | 1 | 0.788 |
MEK1 |
0.834 | -0.096 | 2 | 0.841 |
CAMK1D |
0.834 | 0.175 | -3 | 0.727 |
SMMLCK |
0.834 | 0.149 | -3 | 0.843 |
BRSK1 |
0.833 | 0.044 | -3 | 0.807 |
DCAMKL1 |
0.832 | 0.106 | -3 | 0.800 |
MNK1 |
0.831 | 0.065 | -2 | 0.843 |
AKT1 |
0.831 | 0.180 | -3 | 0.751 |
PKCA |
0.831 | 0.029 | 2 | 0.707 |
MLK2 |
0.831 | -0.173 | 2 | 0.810 |
VRK2 |
0.831 | -0.142 | 1 | 0.850 |
BMPR1A |
0.831 | 0.102 | 1 | 0.808 |
PHKG1 |
0.830 | 0.000 | -3 | 0.828 |
P70S6K |
0.830 | 0.121 | -3 | 0.755 |
JNK3 |
0.829 | 0.035 | 1 | 0.646 |
PKCB |
0.829 | 0.022 | 2 | 0.712 |
MARK3 |
0.829 | 0.022 | 4 | 0.705 |
YSK4 |
0.829 | -0.112 | 1 | 0.769 |
MARK2 |
0.829 | -0.000 | 4 | 0.669 |
CDK19 |
0.829 | -0.018 | 1 | 0.622 |
DCAMKL2 |
0.829 | 0.076 | -3 | 0.828 |
P38A |
0.828 | 0.022 | 1 | 0.680 |
BRSK2 |
0.828 | -0.020 | -3 | 0.815 |
PKCG |
0.828 | -0.002 | 2 | 0.710 |
TTBK2 |
0.828 | -0.213 | 2 | 0.693 |
DAPK3 |
0.828 | 0.189 | -3 | 0.824 |
PASK |
0.828 | 0.121 | -3 | 0.867 |
PKCH |
0.828 | 0.001 | 2 | 0.708 |
BRAF |
0.828 | 0.003 | -4 | 0.810 |
CDK7 |
0.827 | -0.024 | 1 | 0.665 |
DYRK4 |
0.827 | 0.095 | 1 | 0.612 |
GRK2 |
0.827 | -0.022 | -2 | 0.674 |
HIPK1 |
0.827 | 0.090 | 1 | 0.696 |
NEK2 |
0.827 | -0.111 | 2 | 0.799 |
IRE1 |
0.827 | -0.142 | 1 | 0.759 |
DYRK1A |
0.826 | 0.080 | 1 | 0.714 |
GSK3B |
0.826 | 0.092 | 4 | 0.566 |
DAPK1 |
0.826 | 0.191 | -3 | 0.816 |
CDK1 |
0.825 | 0.008 | 1 | 0.630 |
MARK1 |
0.825 | -0.006 | 4 | 0.728 |
CDK13 |
0.824 | -0.026 | 1 | 0.636 |
MLK3 |
0.824 | -0.115 | 2 | 0.714 |
SGK1 |
0.824 | 0.205 | -3 | 0.675 |
P38B |
0.824 | 0.021 | 1 | 0.614 |
CDK18 |
0.824 | 0.016 | 1 | 0.600 |
SNRK |
0.824 | -0.108 | 2 | 0.713 |
HIPK2 |
0.824 | 0.076 | 1 | 0.593 |
TLK2 |
0.823 | -0.106 | 1 | 0.783 |
DYRK3 |
0.823 | 0.114 | 1 | 0.695 |
PKCZ |
0.823 | -0.053 | 2 | 0.765 |
CDK5 |
0.823 | 0.002 | 1 | 0.683 |
GSK3A |
0.823 | 0.104 | 4 | 0.580 |
CAMK1A |
0.822 | 0.171 | -3 | 0.707 |
CK2A2 |
0.822 | 0.127 | 1 | 0.768 |
IRE2 |
0.821 | -0.123 | 2 | 0.751 |
MLK4 |
0.821 | -0.123 | 2 | 0.701 |
CDK14 |
0.821 | 0.049 | 1 | 0.643 |
GAK |
0.821 | 0.108 | 1 | 0.851 |
CHK2 |
0.821 | 0.146 | -3 | 0.692 |
DYRK1B |
0.821 | 0.069 | 1 | 0.636 |
CHAK1 |
0.820 | -0.180 | 2 | 0.770 |
PLK4 |
0.820 | -0.091 | 2 | 0.669 |
HRI |
0.820 | -0.166 | -2 | 0.843 |
MEKK3 |
0.820 | -0.144 | 1 | 0.792 |
PERK |
0.820 | -0.148 | -2 | 0.830 |
MRCKA |
0.819 | 0.195 | -3 | 0.784 |
PHKG2 |
0.819 | 0.015 | -3 | 0.814 |
ERK2 |
0.819 | -0.029 | 1 | 0.644 |
PAK5 |
0.819 | 0.081 | -2 | 0.697 |
HIPK3 |
0.819 | 0.050 | 1 | 0.679 |
CDK17 |
0.819 | -0.001 | 1 | 0.553 |
P38G |
0.819 | 0.014 | 1 | 0.542 |
ERK1 |
0.819 | -0.015 | 1 | 0.605 |
WNK4 |
0.819 | -0.089 | -2 | 0.872 |
CDK2 |
0.818 | -0.047 | 1 | 0.718 |
ZAK |
0.818 | -0.118 | 1 | 0.783 |
AKT3 |
0.818 | 0.178 | -3 | 0.688 |
MEKK1 |
0.818 | -0.151 | 1 | 0.795 |
PLK2 |
0.818 | 0.086 | -3 | 0.819 |
SBK |
0.818 | 0.169 | -3 | 0.643 |
CDK12 |
0.817 | -0.026 | 1 | 0.608 |
NEK5 |
0.817 | -0.105 | 1 | 0.809 |
PRP4 |
0.817 | -0.036 | -3 | 0.700 |
PAK4 |
0.817 | 0.089 | -2 | 0.705 |
MST3 |
0.817 | -0.019 | 2 | 0.817 |
MEK5 |
0.817 | -0.258 | 2 | 0.824 |
PINK1 |
0.816 | -0.167 | 1 | 0.807 |
CDK9 |
0.816 | -0.045 | 1 | 0.643 |
P38D |
0.815 | 0.038 | 1 | 0.560 |
CK1E |
0.815 | -0.046 | -3 | 0.542 |
MRCKB |
0.815 | 0.168 | -3 | 0.772 |
MPSK1 |
0.815 | 0.014 | 1 | 0.779 |
PKCT |
0.815 | 0.010 | 2 | 0.718 |
CAMKK1 |
0.815 | -0.072 | -2 | 0.818 |
GRK3 |
0.815 | -0.023 | -2 | 0.621 |
IRAK4 |
0.814 | -0.106 | 1 | 0.765 |
CDK10 |
0.814 | 0.051 | 1 | 0.629 |
CK2A1 |
0.814 | 0.119 | 1 | 0.751 |
TLK1 |
0.814 | -0.154 | -2 | 0.809 |
PKN1 |
0.813 | 0.089 | -3 | 0.764 |
SSTK |
0.813 | -0.030 | 4 | 0.729 |
TAO3 |
0.813 | -0.070 | 1 | 0.788 |
PDK1 |
0.812 | -0.003 | 1 | 0.804 |
MEKK2 |
0.812 | -0.171 | 2 | 0.799 |
CDK3 |
0.812 | 0.010 | 1 | 0.571 |
CDK16 |
0.811 | 0.031 | 1 | 0.569 |
DMPK1 |
0.811 | 0.214 | -3 | 0.793 |
PDHK3_TYR |
0.811 | 0.245 | 4 | 0.902 |
ROCK2 |
0.810 | 0.166 | -3 | 0.802 |
IRAK1 |
0.810 | -0.189 | -1 | 0.758 |
NEK11 |
0.810 | -0.158 | 1 | 0.792 |
PKCI |
0.810 | -0.015 | 2 | 0.724 |
CAMKK2 |
0.810 | -0.085 | -2 | 0.814 |
PKCE |
0.809 | 0.047 | 2 | 0.697 |
NEK8 |
0.808 | -0.164 | 2 | 0.810 |
CK1D |
0.808 | -0.044 | -3 | 0.487 |
JNK1 |
0.808 | 0.014 | 1 | 0.609 |
TTBK1 |
0.808 | -0.174 | 2 | 0.616 |
LKB1 |
0.808 | -0.077 | -3 | 0.788 |
CK1A2 |
0.808 | -0.035 | -3 | 0.491 |
GCK |
0.807 | -0.021 | 1 | 0.790 |
TAK1 |
0.807 | -0.047 | 1 | 0.820 |
TAO2 |
0.807 | -0.116 | 2 | 0.834 |
BUB1 |
0.806 | 0.107 | -5 | 0.843 |
MAK |
0.805 | 0.108 | -2 | 0.717 |
EEF2K |
0.804 | -0.074 | 3 | 0.817 |
MST2 |
0.804 | -0.103 | 1 | 0.792 |
CRIK |
0.804 | 0.158 | -3 | 0.754 |
VRK1 |
0.803 | -0.077 | 2 | 0.854 |
NEK4 |
0.803 | -0.135 | 1 | 0.762 |
CK1G1 |
0.803 | -0.090 | -3 | 0.534 |
NEK1 |
0.802 | -0.071 | 1 | 0.775 |
RIPK2 |
0.801 | -0.170 | 1 | 0.743 |
HPK1 |
0.801 | -0.036 | 1 | 0.771 |
PDHK4_TYR |
0.801 | 0.075 | 2 | 0.878 |
LRRK2 |
0.800 | -0.166 | 2 | 0.839 |
MAP3K15 |
0.800 | -0.128 | 1 | 0.765 |
MINK |
0.800 | -0.106 | 1 | 0.772 |
MOK |
0.799 | 0.082 | 1 | 0.696 |
TNIK |
0.799 | -0.065 | 3 | 0.844 |
TESK1_TYR |
0.799 | -0.030 | 3 | 0.890 |
MAP2K6_TYR |
0.799 | 0.032 | -1 | 0.869 |
MAP2K4_TYR |
0.799 | -0.015 | -1 | 0.874 |
ERK7 |
0.799 | -0.048 | 2 | 0.500 |
LOK |
0.798 | -0.069 | -2 | 0.808 |
HGK |
0.798 | -0.116 | 3 | 0.846 |
BMPR2_TYR |
0.798 | 0.033 | -1 | 0.866 |
PBK |
0.798 | 0.040 | 1 | 0.770 |
EPHB4 |
0.798 | 0.129 | -1 | 0.887 |
ROCK1 |
0.797 | 0.140 | -3 | 0.776 |
PKG1 |
0.797 | 0.087 | -2 | 0.665 |
MEK2 |
0.796 | -0.200 | 2 | 0.817 |
CDK4 |
0.796 | -0.014 | 1 | 0.599 |
EPHA6 |
0.796 | 0.086 | -1 | 0.884 |
MEKK6 |
0.795 | -0.185 | 1 | 0.766 |
MST1 |
0.795 | -0.132 | 1 | 0.773 |
BIKE |
0.795 | 0.098 | 1 | 0.742 |
MAP2K7_TYR |
0.795 | -0.175 | 2 | 0.863 |
CDK6 |
0.794 | -0.029 | 1 | 0.620 |
PKMYT1_TYR |
0.794 | -0.084 | 3 | 0.865 |
KHS2 |
0.794 | -0.009 | 1 | 0.774 |
PDHK1_TYR |
0.793 | -0.064 | -1 | 0.877 |
PINK1_TYR |
0.793 | -0.146 | 1 | 0.832 |
KHS1 |
0.793 | -0.052 | 1 | 0.757 |
STK33 |
0.792 | -0.178 | 2 | 0.618 |
RET |
0.791 | -0.022 | 1 | 0.787 |
SLK |
0.791 | -0.119 | -2 | 0.727 |
YSK1 |
0.790 | -0.118 | 2 | 0.789 |
DDR1 |
0.790 | -0.016 | 4 | 0.809 |
TXK |
0.790 | 0.144 | 1 | 0.848 |
LIMK2_TYR |
0.790 | -0.046 | -3 | 0.858 |
EPHB1 |
0.789 | 0.085 | 1 | 0.832 |
EPHA4 |
0.789 | 0.046 | 2 | 0.781 |
TTK |
0.788 | -0.027 | -2 | 0.818 |
EPHB3 |
0.788 | 0.084 | -1 | 0.883 |
EPHB2 |
0.788 | 0.102 | -1 | 0.872 |
MST1R |
0.787 | -0.086 | 3 | 0.834 |
TYK2 |
0.786 | -0.129 | 1 | 0.783 |
INSRR |
0.786 | 0.020 | 3 | 0.775 |
YES1 |
0.785 | 0.019 | -1 | 0.843 |
FER |
0.785 | -0.049 | 1 | 0.858 |
TYRO3 |
0.785 | -0.075 | 3 | 0.814 |
SRMS |
0.785 | 0.033 | 1 | 0.843 |
NEK3 |
0.784 | -0.174 | 1 | 0.735 |
ALPHAK3 |
0.784 | -0.059 | -1 | 0.763 |
ABL2 |
0.783 | -0.007 | -1 | 0.826 |
JAK2 |
0.782 | -0.123 | 1 | 0.779 |
CSF1R |
0.782 | -0.078 | 3 | 0.811 |
OSR1 |
0.782 | -0.114 | 2 | 0.792 |
ROS1 |
0.782 | -0.105 | 3 | 0.787 |
LIMK1_TYR |
0.781 | -0.237 | 2 | 0.852 |
JAK3 |
0.781 | -0.077 | 1 | 0.785 |
YANK3 |
0.781 | -0.078 | 2 | 0.395 |
FGFR2 |
0.780 | -0.060 | 3 | 0.826 |
HCK |
0.780 | -0.029 | -1 | 0.839 |
ASK1 |
0.780 | -0.150 | 1 | 0.758 |
MERTK |
0.780 | 0.027 | 3 | 0.805 |
AAK1 |
0.779 | 0.126 | 1 | 0.642 |
EPHA7 |
0.779 | 0.037 | 2 | 0.784 |
TNK2 |
0.779 | -0.026 | 3 | 0.792 |
FGR |
0.779 | -0.104 | 1 | 0.837 |
AXL |
0.779 | -0.017 | 3 | 0.805 |
PDGFRB |
0.778 | -0.087 | 3 | 0.831 |
ABL1 |
0.778 | -0.043 | -1 | 0.821 |
EPHA3 |
0.778 | -0.017 | 2 | 0.756 |
ITK |
0.778 | -0.020 | -1 | 0.828 |
KIT |
0.777 | -0.084 | 3 | 0.819 |
HASPIN |
0.777 | -0.073 | -1 | 0.648 |
MYO3B |
0.777 | -0.113 | 2 | 0.802 |
EPHA5 |
0.777 | 0.066 | 2 | 0.775 |
TEC |
0.777 | 0.011 | -1 | 0.791 |
LCK |
0.776 | -0.005 | -1 | 0.834 |
FLT3 |
0.776 | -0.096 | 3 | 0.810 |
BLK |
0.775 | 0.029 | -1 | 0.837 |
KDR |
0.775 | -0.068 | 3 | 0.788 |
BMX |
0.775 | -0.001 | -1 | 0.751 |
TEK |
0.775 | -0.095 | 3 | 0.761 |
NTRK1 |
0.775 | -0.073 | -1 | 0.853 |
DDR2 |
0.775 | 0.078 | 3 | 0.766 |
FYN |
0.775 | 0.043 | -1 | 0.807 |
TAO1 |
0.774 | -0.140 | 1 | 0.709 |
LTK |
0.773 | -0.054 | 3 | 0.775 |
NEK10_TYR |
0.773 | -0.096 | 1 | 0.676 |
FGFR1 |
0.773 | -0.116 | 3 | 0.797 |
BTK |
0.773 | -0.094 | -1 | 0.807 |
PTK2B |
0.773 | 0.043 | -1 | 0.809 |
JAK1 |
0.773 | -0.070 | 1 | 0.736 |
PDGFRA |
0.772 | -0.147 | 3 | 0.827 |
ALK |
0.772 | -0.076 | 3 | 0.753 |
MYO3A |
0.772 | -0.156 | 1 | 0.747 |
TNK1 |
0.771 | -0.101 | 3 | 0.799 |
EPHA1 |
0.771 | -0.029 | 3 | 0.799 |
CK1A |
0.770 | -0.068 | -3 | 0.398 |
FGFR3 |
0.770 | -0.083 | 3 | 0.801 |
WEE1_TYR |
0.769 | -0.105 | -1 | 0.770 |
ERBB2 |
0.769 | -0.124 | 1 | 0.776 |
FLT1 |
0.769 | -0.083 | -1 | 0.849 |
MET |
0.768 | -0.113 | 3 | 0.816 |
NTRK2 |
0.768 | -0.120 | 3 | 0.785 |
FRK |
0.767 | -0.064 | -1 | 0.859 |
FLT4 |
0.767 | -0.119 | 3 | 0.779 |
EPHA8 |
0.767 | -0.020 | -1 | 0.848 |
LYN |
0.767 | -0.047 | 3 | 0.741 |
PTK6 |
0.767 | -0.169 | -1 | 0.764 |
STLK3 |
0.767 | -0.201 | 1 | 0.739 |
INSR |
0.766 | -0.100 | 3 | 0.746 |
TNNI3K_TYR |
0.766 | -0.110 | 1 | 0.773 |
PTK2 |
0.765 | 0.040 | -1 | 0.798 |
NTRK3 |
0.763 | -0.109 | -1 | 0.807 |
EGFR |
0.762 | -0.058 | 1 | 0.694 |
SRC |
0.761 | -0.047 | -1 | 0.809 |
EPHA2 |
0.760 | -0.014 | -1 | 0.820 |
SYK |
0.759 | 0.001 | -1 | 0.781 |
CSK |
0.758 | -0.127 | 2 | 0.783 |
FGFR4 |
0.756 | -0.093 | -1 | 0.789 |
MATK |
0.756 | -0.144 | -1 | 0.740 |
IGF1R |
0.754 | -0.103 | 3 | 0.693 |
MUSK |
0.752 | -0.123 | 1 | 0.678 |
ERBB4 |
0.750 | -0.054 | 1 | 0.713 |
CK1G3 |
0.747 | -0.093 | -3 | 0.351 |
FES |
0.743 | -0.091 | -1 | 0.732 |
YANK2 |
0.740 | -0.133 | 2 | 0.407 |
CK1G2 |
0.727 | -0.104 | -3 | 0.449 |
ZAP70 |
0.727 | -0.091 | -1 | 0.695 |