Motif 600 (n=209)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S1469 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6H8Y1 | BDP1 | S431 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| H0Y626 | None | S48 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| H0YC42 | None | S171 | ochoa | Tumor protein D52 | None |
| O00299 | CLIC1 | S163 | ochoa | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}. |
| O00559 | EBAG9 | S50 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14602 | EIF1AY | S102 | ochoa | Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. {ECO:0000250|UniProtKB:P47813}. |
| O14617 | AP3D1 | S721 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O14775 | GNB5 | S63 | ochoa | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (PubMed:27677260). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000250|UniProtKB:P62881, ECO:0000269|PubMed:27677260}. |
| O14981 | BTAF1 | S1549 | ochoa | TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) | Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. |
| O43683 | BUB1 | S419 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43776 | NARS1 | S88 | ochoa | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
| O60216 | RAD21 | S449 | ochoa | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
| O60941 | DTNB | S608 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75113 | N4BP1 | S335 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75151 | PHF2 | S853 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75475 | PSIP1 | S443 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75688 | PPM1B | S376 | ochoa | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O75762 | TRPA1 | S35 | ochoa | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75844 | ZMPSTE24 | S298 | ochoa | CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33293369, PubMed:33315887). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33293369, PubMed:33315887). Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28169297, PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811). {ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:28246125, ECO:0000269|PubMed:33293369, ECO:0000269|PubMed:33315887, ECO:0000269|PubMed:35283811}. |
| O95096 | NKX2-2 | S27 | ochoa | Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) | Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). {ECO:0000250|UniProtKB:P42586}. |
| O95279 | KCNK5 | S438 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
| O95361 | TRIM16 | S48 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95391 | SLU7 | S215 | ochoa | Pre-mRNA-splicing factor SLU7 (hSlu7) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| P02545 | LMNA | S282 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P06753 | TPM3 | S216 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07951 | TPM2 | S215 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P11137 | MAP2 | S1021 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12268 | IMPDH2 | S160 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P13521 | SCG2 | S532 | ochoa|psp | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P13569 | CFTR | S686 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P15260 | IFNGR1 | S351 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P15923 | TCF3 | T508 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P15924 | DSP | S1361 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P18858 | LIG1 | T207 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P19174 | PLCG1 | S524 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P19174 | PLCG1 | S525 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P20309 | CHRM3 | S386 | ochoa | Muscarinic acetylcholine receptor M3 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| P22059 | OSBP | S244 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22694 | PRKACB | S326 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P24534 | EEF1B2 | S112 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P28290 | ITPRID2 | S385 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29374 | ARID4A | S538 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30203 | CD6 | S505 | psp | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}. |
| P35269 | GTF2F1 | S218 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35579 | MYH9 | S45 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1340 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1009 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1291 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1347 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36888 | FLT3 | Y768 | psp | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P37275 | ZEB1 | S46 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P39656 | DDOST | S143 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853). {ECO:0000250|UniProtKB:Q05052, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:31831667}. |
| P40227 | CCT6A | S246 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P43243 | MATR3 | S620 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P45379 | TNNT2 | S208 | psp | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P46013 | MKI67 | S3067 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P47813 | EIF1AX | S102 | ochoa | Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:9732867). This protein enhances formation of the cap-proximal complex (PubMed:9732867). Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:35732735). Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B (PubMed:35732735). Its globular part is located in the A site of the 40S ribosomal subunit (PubMed:35732735). Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). In contrast to yeast orthologs, does not bind EIF1 (PubMed:24319994). {ECO:0000269|PubMed:24319994, ECO:0000269|PubMed:35732735, ECO:0000269|PubMed:9732867}. |
| P48444 | ARCN1 | S252 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48681 | NES | S517 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S1492 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S1502 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P51946 | CCNH | S304 | psp | Cyclin-H (MO15-associated protein) (p34) (p37) | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}. |
| P52701 | MSH6 | S280 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P53621 | COPA | S773 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P54105 | CLNS1A | S90 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P55072 | VCP | S284 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P60709 | ACTB | S60 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S62 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S60 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S61 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P67936 | TPM4 | S179 | ochoa | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}. |
| P68032 | ACTC1 | S62 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S62 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78332 | RBM6 | S379 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78559 | MAP1A | S1600 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01831 | XPC | S129 | psp | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q01831 | XPC | S903 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02952 | AKAP12 | S1395 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03468 | ERCC6 | S486 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q04637 | EIF4G1 | S1194 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05D32 | CTDSPL2 | S165 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q07666 | KHDRBS1 | S202 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q12888 | TP53BP1 | S63 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S222 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1216 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13136 | PPFIA1 | S238 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13428 | TCOF1 | S272 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S1410 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14149 | MORC3 | S771 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14152 | EIF3A | S584 | ochoa|psp | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14683 | SMC1A | S360 | ochoa|psp | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q14847 | LASP1 | S82 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14980 | NUMA1 | S271 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15052 | ARHGEF6 | S684 | ochoa|psp | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15054 | POLD3 | S407 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15058 | KIF14 | S100 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15283 | RASA2 | S560 | ochoa | Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). |
| Q15468 | STIL | S1131 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15772 | SPEG | S2322 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16665 | HIF1A | S696 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q32MZ4 | LRRFIP1 | S686 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q49MG5 | MAP9 | S305 | psp | Microtubule-associated protein 9 (Aster-associated protein) | Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}. |
| Q5R372 | RABGAP1L | S459 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SSJ5 | HP1BP3 | S441 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T8D3 | ACBD5 | S256 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
| Q5T8I3 | EEIG2 | S317 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5TH69 | ARFGEF3 | S632 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VZL5 | ZMYM4 | S1100 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q63HN8 | RNF213 | S1264 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q63HQ0 | AP1AR | S205 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q641Q2 | WASHC2A | S478 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S614 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6DN12 | MCTP2 | S738 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6P158 | DHX57 | S127 | ochoa | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
| Q6P6B1 | ERICH5 | S354 | ochoa | Glutamate-rich protein 5 | None |
| Q6ZVM7 | TOM1L2 | S457 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q7KZ85 | SUPT6H | S125 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7L7X3 | TAOK1 | S394 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z2Z1 | TICRR | S1590 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6Z7 | HUWE1 | S2377 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UX7 | FERMT3 | S31 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86X10 | RALGAPB | S1022 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86YC2 | PALB2 | S172 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IVF2 | AHNAK2 | S5714 | ochoa | Protein AHNAK2 | None |
| Q8IW35 | CEP97 | S445 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWB9 | TEX2 | S408 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IX01 | SUGP2 | S1042 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IYH5 | ZZZ3 | S472 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IZL8 | PELP1 | S1059 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N201 | INTS1 | S295 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N4X5 | AFAP1L2 | S414 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N9B5 | JMY | S723 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NBI5 | SLC43A3 | S248 | ochoa | Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3) | Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (PubMed:26455426, PubMed:32339528). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake (By similarity). {ECO:0000250|UniProtKB:A2AVZ9, ECO:0000269|PubMed:26455426, ECO:0000269|PubMed:32339528}.; FUNCTION: [Isoform 1]: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine (PubMed:30910793). Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane (PubMed:30910793). {ECO:0000269|PubMed:30910793}.; FUNCTION: [Isoform 2]: Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine (PubMed:30910793). Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane (PubMed:30910793). {ECO:0000269|PubMed:30910793}. |
| Q8NFG4 | FLCN | S298 | ochoa | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8TAQ2 | SMARCC2 | S387 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TD57 | DNAH3 | S3752 | ochoa | Dynein axonemal heavy chain 3 (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b) | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. |
| Q8TDC0 | MYOZ3 | S31 | ochoa | Myozenin-3 (Calsarcin-3) (FATZ-related protein 3) | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q8TEM1 | NUP210 | S150 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TF01 | PNISR | S321 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WUJ0 | STYX | S201 | ochoa | Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) | Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. |
| Q8WUY3 | PRUNE2 | S2866 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WXI9 | GATAD2B | S135 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q8WZ42 | TTN | S4010 | psp | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q92526 | CCT6B | S246 | ochoa | T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. {ECO:0000305|PubMed:8812458}. |
| Q92529 | SHC3 | S324 | ochoa | SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
| Q92539 | LPIN2 | S199 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92576 | PHF3 | S97 | ochoa | PHD finger protein 3 | None |
| Q92576 | PHF3 | S1063 | ochoa | PHD finger protein 3 | None |
| Q92736 | RYR2 | S2368 | psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q92769 | HDAC2 | S411 | psp | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
| Q96PY6 | NEK1 | S1092 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96QE2 | SLC2A13 | S294 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96RS0 | TGS1 | S55 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96ST8 | CEP89 | S292 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q96T23 | RSF1 | S1336 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T88 | UHRF1 | S171 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99442 | SEC62 | S313 | ochoa | Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) | Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q99549 | MPHOSPH8 | S20 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99733 | NAP1L4 | S121 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q99801 | NKX3-1 | S195 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BQG0 | MYBBP1A | S738 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BRU9 | UTP23 | S174 | ochoa | rRNA-processing protein UTP23 homolog | Involved in rRNA-processing and ribosome biogenesis. {ECO:0000250}. |
| Q9BVS4 | RIOK2 | S354 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BWQ6 | YIPF2 | S60 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9BXK5 | BCL2L13 | S375 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXP5 | SRRT | S675 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BZI7 | UPF3B | S415 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9BZQ8 | NIBAN1 | S615 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9GZP1 | NRSN2 | S157 | ochoa | Neurensin-2 | May play a role in maintenance and/or transport of vesicles. |
| Q9H089 | LSG1 | S97 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H6A9 | PCNX3 | S95 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6T3 | RPAP3 | S114 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H6X5 | C19orf44 | S239 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9H6X5 | C19orf44 | S375 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9HC44 | GPBP1L1 | S353 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NP98 | MYOZ1 | S39 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NQ66 | PLCB1 | S569 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9NQX4 | MYO5C | S1247 | ochoa | Unconventional myosin-Vc | May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. |
| Q9NSI6 | BRWD1 | S1683 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NY61 | AATF | S320 | ochoa|psp | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYF8 | BCLAF1 | S177 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S472 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9UDY2 | TJP2 | S1156 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGP8 | SEC63 | S570 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UHB6 | LIMA1 | S709 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UMZ2 | SYNRG | S1044 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPQ0 | LIMCH1 | S327 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPR3 | SMG5 | S523 | ochoa | Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}. |
| Q9UQM7 | CAMK2A | S333 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2D4 | EXOC6B | S269 | ochoa | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q9Y2W1 | THRAP3 | S494 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3P9 | RABGAP1 | S37 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y487 | ATP6V0A2 | S700 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
| Q9Y597 | KCTD3 | S738 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5B9 | SUPT16H | S986 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| P05787 | KRT8 | S280 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P27797 | CALR | S52 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P08684 | CYP3A4 | S116 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P17612 | PRKACA | S326 | GPS6 | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| Q9BRS2 | RIOK1 | S504 | Sugiyama | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}. |
| P10809 | HSPD1 | S159 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P57059 | SIK1 | S117 | Sugiyama | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| Q8WU90 | ZC3H15 | S135 | Sugiyama | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q9NYU2 | UGGT1 | S366 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| Q9H788 | SH2D4A | S159 | Sugiyama | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9BQI3 | EIF2AK1 | S253 | Sugiyama | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
| Q9H4A3 | WNK1 | S198 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9Y2T3 | GDA | S49 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-390522 | Striated Muscle Contraction | 0.000002 | 5.730 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.000001 | 5.952 |
| R-HSA-397014 | Muscle contraction | 0.000006 | 5.223 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.000020 | 4.705 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.000026 | 4.589 |
| R-HSA-8853659 | RET signaling | 0.000036 | 4.442 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.000095 | 4.024 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.000095 | 4.024 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.000113 | 3.947 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.000209 | 3.680 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.000240 | 3.620 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.000249 | 3.603 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.000331 | 3.480 |
| R-HSA-111933 | Calmodulin induced events | 0.000376 | 3.425 |
| R-HSA-111997 | CaM pathway | 0.000376 | 3.425 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.000335 | 3.475 |
| R-HSA-112043 | PLC beta mediated events | 0.000458 | 3.339 |
| R-HSA-418990 | Adherens junctions interactions | 0.000579 | 3.237 |
| R-HSA-111996 | Ca-dependent events | 0.000739 | 3.131 |
| R-HSA-112040 | G-protein mediated events | 0.000706 | 3.151 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.000851 | 3.070 |
| R-HSA-422356 | Regulation of insulin secretion | 0.000929 | 3.032 |
| R-HSA-446728 | Cell junction organization | 0.001082 | 2.966 |
| R-HSA-111885 | Opioid Signalling | 0.001262 | 2.899 |
| R-HSA-421270 | Cell-cell junction organization | 0.001627 | 2.789 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.001827 | 2.738 |
| R-HSA-8963896 | HDL assembly | 0.002147 | 2.668 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.002321 | 2.634 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.002500 | 2.602 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.002500 | 2.602 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.002398 | 2.620 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.002886 | 2.540 |
| R-HSA-1500931 | Cell-Cell communication | 0.002895 | 2.538 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.003307 | 2.481 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.003410 | 2.467 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.003764 | 2.424 |
| R-HSA-5358508 | Mismatch Repair | 0.004258 | 2.371 |
| R-HSA-163615 | PKA activation | 0.004258 | 2.371 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.004258 | 2.371 |
| R-HSA-201556 | Signaling by ALK | 0.004133 | 2.384 |
| R-HSA-194138 | Signaling by VEGF | 0.003746 | 2.426 |
| R-HSA-392517 | Rap1 signalling | 0.004789 | 2.320 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.005550 | 2.256 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.005270 | 2.278 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.005527 | 2.257 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.005527 | 2.257 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.006312 | 2.200 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.006758 | 2.170 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.007103 | 2.149 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.005966 | 2.224 |
| R-HSA-4086398 | Ca2+ pathway | 0.005841 | 2.234 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.006758 | 2.170 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.006790 | 2.168 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.006454 | 2.190 |
| R-HSA-163685 | Integration of energy metabolism | 0.006005 | 2.221 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007185 | 2.144 |
| R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | 0.007185 | 2.144 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.006832 | 2.165 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.006832 | 2.165 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.008032 | 2.095 |
| R-HSA-9634597 | GPER1 signaling | 0.008158 | 2.088 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.008568 | 2.067 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.008611 | 2.065 |
| R-HSA-8849473 | PTK6 Expression | 0.008791 | 2.056 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.008791 | 2.056 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.008803 | 2.055 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.008803 | 2.055 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.009731 | 2.012 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.009779 | 2.010 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 0.013815 | 1.860 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.013815 | 1.860 |
| R-HSA-196025 | Formation of annular gap junctions | 0.010540 | 1.977 |
| R-HSA-190873 | Gap junction degradation | 0.012431 | 1.906 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.014457 | 1.840 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.013292 | 1.876 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.010302 | 1.987 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.010890 | 1.963 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.012781 | 1.893 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.011577 | 1.936 |
| R-HSA-391251 | Protein folding | 0.014677 | 1.833 |
| R-HSA-180024 | DARPP-32 events | 0.013292 | 1.876 |
| R-HSA-68875 | Mitotic Prophase | 0.011762 | 1.930 |
| R-HSA-68886 | M Phase | 0.011524 | 1.938 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.010540 | 1.977 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.010540 | 1.977 |
| R-HSA-1640170 | Cell Cycle | 0.014014 | 1.853 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.012781 | 1.893 |
| R-HSA-8979227 | Triglyceride metabolism | 0.014870 | 1.828 |
| R-HSA-162582 | Signal Transduction | 0.014956 | 1.825 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.015391 | 1.813 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.015612 | 1.807 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.015612 | 1.807 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.016376 | 1.786 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.016506 | 1.782 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.018870 | 1.724 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.017666 | 1.753 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.017666 | 1.753 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.018870 | 1.724 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.016661 | 1.778 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.018902 | 1.723 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.018902 | 1.723 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.019666 | 1.706 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.020118 | 1.696 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.021411 | 1.669 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.021714 | 1.663 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.022383 | 1.650 |
| R-HSA-163560 | Triglyceride catabolism | 0.022749 | 1.643 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.023337 | 1.632 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.023845 | 1.623 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.026493 | 1.577 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.027028 | 1.568 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.027398 | 1.562 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.024316 | 1.614 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.026952 | 1.569 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.023845 | 1.623 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.027439 | 1.562 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.028475 | 1.546 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.028543 | 1.544 |
| R-HSA-167169 | HIV Transcription Elongation | 0.028543 | 1.544 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.028543 | 1.544 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.028543 | 1.544 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.029254 | 1.534 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.029254 | 1.534 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.029577 | 1.529 |
| R-HSA-68877 | Mitotic Prometaphase | 0.030040 | 1.522 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.030704 | 1.513 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.031707 | 1.499 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.031707 | 1.499 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.031707 | 1.499 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.031707 | 1.499 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.033032 | 1.481 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.035100 | 1.455 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.040381 | 1.394 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.040381 | 1.394 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.040381 | 1.394 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.040381 | 1.394 |
| R-HSA-162587 | HIV Life Cycle | 0.036904 | 1.433 |
| R-HSA-4839726 | Chromatin organization | 0.035910 | 1.445 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.038179 | 1.418 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.035462 | 1.450 |
| R-HSA-9659379 | Sensory processing of sound | 0.034235 | 1.466 |
| R-HSA-75153 | Apoptotic execution phase | 0.040381 | 1.394 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.040876 | 1.389 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.040876 | 1.389 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.041356 | 1.383 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.041356 | 1.383 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.041356 | 1.383 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.041356 | 1.383 |
| R-HSA-73894 | DNA Repair | 0.041442 | 1.383 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.041602 | 1.381 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.041977 | 1.377 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.047995 | 1.319 |
| R-HSA-1221632 | Meiotic synapsis | 0.054316 | 1.265 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.054316 | 1.265 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.051451 | 1.289 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.053321 | 1.273 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.053321 | 1.273 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.051451 | 1.289 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.046190 | 1.335 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.046102 | 1.336 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.045045 | 1.346 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.047995 | 1.319 |
| R-HSA-68882 | Mitotic Anaphase | 0.048534 | 1.314 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.049433 | 1.306 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.051451 | 1.289 |
| R-HSA-1266738 | Developmental Biology | 0.052731 | 1.278 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.045901 | 1.338 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.054992 | 1.260 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.054992 | 1.260 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.055297 | 1.257 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.055502 | 1.256 |
| R-HSA-72649 | Translation initiation complex formation | 0.056472 | 1.248 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.058668 | 1.232 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.067199 | 1.173 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.067199 | 1.173 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.080089 | 1.096 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.080089 | 1.096 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.080089 | 1.096 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.062322 | 1.205 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.062322 | 1.205 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.066104 | 1.180 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.077887 | 1.109 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.077887 | 1.109 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.077887 | 1.109 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.060904 | 1.215 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.065494 | 1.184 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.065494 | 1.184 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.069961 | 1.155 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.069961 | 1.155 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.069961 | 1.155 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.067847 | 1.168 |
| R-HSA-191859 | snRNP Assembly | 0.067847 | 1.168 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.077887 | 1.109 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.073890 | 1.131 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.067199 | 1.173 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.080089 | 1.096 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.064060 | 1.193 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.074309 | 1.129 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.077887 | 1.109 |
| R-HSA-5578775 | Ion homeostasis | 0.060904 | 1.215 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.069961 | 1.155 |
| R-HSA-9658195 | Leishmania infection | 0.061256 | 1.213 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.061256 | 1.213 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.077635 | 1.110 |
| R-HSA-8848021 | Signaling by PTK6 | 0.077635 | 1.110 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.077887 | 1.109 |
| R-HSA-70171 | Glycolysis | 0.070633 | 1.151 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.078080 | 1.107 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.068197 | 1.166 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.070238 | 1.153 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.072859 | 1.138 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.064060 | 1.193 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.069961 | 1.155 |
| R-HSA-9675108 | Nervous system development | 0.080340 | 1.095 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.081952 | 1.086 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.081952 | 1.086 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.081952 | 1.086 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.081952 | 1.086 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.081952 | 1.086 |
| R-HSA-69242 | S Phase | 0.083789 | 1.077 |
| R-HSA-72086 | mRNA Capping | 0.086080 | 1.065 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.087081 | 1.060 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.090270 | 1.044 |
| R-HSA-167172 | Transcription of the HIV genome | 0.090683 | 1.042 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.091643 | 1.038 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.092802 | 1.032 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.092802 | 1.032 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.092802 | 1.032 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.092802 | 1.032 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.092802 | 1.032 |
| R-HSA-429593 | Inositol transporters | 0.092802 | 1.032 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.092802 | 1.032 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.093863 | 1.028 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.094518 | 1.024 |
| R-HSA-69190 | DNA strand elongation | 0.098823 | 1.005 |
| R-HSA-422475 | Axon guidance | 0.099145 | 1.004 |
| R-HSA-9645135 | STAT5 Activation | 0.117705 | 0.929 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.117705 | 0.929 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.129901 | 0.886 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.129901 | 0.886 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.129901 | 0.886 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.141928 | 0.848 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.107593 | 0.968 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.112054 | 0.951 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.125712 | 0.901 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.149271 | 0.826 |
| R-HSA-167161 | HIV Transcription Initiation | 0.149271 | 0.826 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.149271 | 0.826 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.104574 | 0.981 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.131496 | 0.881 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.144167 | 0.841 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.144167 | 0.841 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.147396 | 0.832 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.125712 | 0.901 |
| R-HSA-9646399 | Aggrephagy | 0.139740 | 0.855 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.149271 | 0.826 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.129901 | 0.886 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.139740 | 0.855 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.139740 | 0.855 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.139740 | 0.855 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.149271 | 0.826 |
| R-HSA-9843745 | Adipogenesis | 0.150246 | 0.823 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.135164 | 0.869 |
| R-HSA-162906 | HIV Infection | 0.132470 | 0.878 |
| R-HSA-1500620 | Meiosis | 0.140962 | 0.851 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.111958 | 0.951 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.139740 | 0.855 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.139740 | 0.855 |
| R-HSA-8953854 | Metabolism of RNA | 0.142939 | 0.845 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.117705 | 0.929 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.117705 | 0.929 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.103182 | 0.986 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.112054 | 0.951 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.149271 | 0.826 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.108323 | 0.965 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.125712 | 0.901 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.144489 | 0.840 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.105340 | 0.977 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.107448 | 0.969 |
| R-HSA-5576891 | Cardiac conduction | 0.150246 | 0.823 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.119244 | 0.924 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.103182 | 0.986 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.144489 | 0.840 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.100469 | 0.998 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.103182 | 0.986 |
| R-HSA-70326 | Glucose metabolism | 0.111526 | 0.953 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.103182 | 0.986 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.140962 | 0.851 |
| R-HSA-1474244 | Extracellular matrix organization | 0.119069 | 0.924 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.153790 | 0.813 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.165489 | 0.781 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.188405 | 0.725 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.199627 | 0.700 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.199627 | 0.700 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.221610 | 0.654 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.221610 | 0.654 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.232376 | 0.634 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.232376 | 0.634 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.242992 | 0.614 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.253463 | 0.596 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.263789 | 0.579 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.263789 | 0.579 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.284018 | 0.547 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.284018 | 0.547 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.293923 | 0.532 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.293923 | 0.532 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.293923 | 0.532 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.293923 | 0.532 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.293923 | 0.532 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.158929 | 0.799 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.168699 | 0.773 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.168699 | 0.773 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.173622 | 0.760 |
| R-HSA-72187 | mRNA 3'-end processing | 0.203593 | 0.691 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.234081 | 0.631 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.249079 | 0.604 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.249079 | 0.604 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.269855 | 0.569 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.160543 | 0.794 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.201888 | 0.695 |
| R-HSA-162592 | Integration of provirus | 0.188405 | 0.725 |
| R-HSA-4641265 | Repression of WNT target genes | 0.199627 | 0.700 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.253463 | 0.596 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.273974 | 0.562 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.154085 | 0.812 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.184948 | 0.733 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.271408 | 0.566 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.284018 | 0.547 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.300666 | 0.522 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.271408 | 0.566 |
| R-HSA-418597 | G alpha (z) signalling events | 0.218790 | 0.660 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.199627 | 0.700 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.199627 | 0.700 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.242992 | 0.614 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.242992 | 0.614 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.273974 | 0.562 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.284018 | 0.547 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.249432 | 0.603 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.273974 | 0.562 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.280196 | 0.553 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.273974 | 0.562 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.273974 | 0.562 |
| R-HSA-418555 | G alpha (s) signalling events | 0.272912 | 0.564 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.153790 | 0.813 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.165489 | 0.781 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.165489 | 0.781 |
| R-HSA-164843 | 2-LTR circle formation | 0.165489 | 0.781 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.188405 | 0.725 |
| R-HSA-9754706 | Atorvastatin ADME | 0.242992 | 0.614 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.242992 | 0.614 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.293923 | 0.532 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.173622 | 0.760 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.234357 | 0.630 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.234357 | 0.630 |
| R-HSA-180786 | Extension of Telomeres | 0.239193 | 0.621 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.188405 | 0.725 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.253463 | 0.596 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.223878 | 0.650 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.256493 | 0.591 |
| R-HSA-73886 | Chromosome Maintenance | 0.290179 | 0.537 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.199627 | 0.700 |
| R-HSA-69091 | Polymerase switching | 0.199627 | 0.700 |
| R-HSA-69109 | Leading Strand Synthesis | 0.199627 | 0.700 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.284018 | 0.547 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.249432 | 0.603 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.282119 | 0.550 |
| R-HSA-5693538 | Homology Directed Repair | 0.278902 | 0.555 |
| R-HSA-195721 | Signaling by WNT | 0.283080 | 0.548 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.284018 | 0.547 |
| R-HSA-437239 | Recycling pathway of L1 | 0.178569 | 0.748 |
| R-HSA-73893 | DNA Damage Bypass | 0.188524 | 0.725 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.199627 | 0.700 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.199627 | 0.700 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.199627 | 0.700 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.221610 | 0.654 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.221610 | 0.654 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.242992 | 0.614 |
| R-HSA-190828 | Gap junction trafficking | 0.163801 | 0.786 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.244310 | 0.612 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.238023 | 0.623 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.242992 | 0.614 |
| R-HSA-9675135 | Diseases of DNA repair | 0.173622 | 0.760 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.168699 | 0.773 |
| R-HSA-5689877 | Josephin domain DUBs | 0.165489 | 0.781 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.242992 | 0.614 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.253463 | 0.596 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.263789 | 0.579 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.263789 | 0.579 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.188524 | 0.725 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.275070 | 0.561 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.261919 | 0.582 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.234357 | 0.630 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.249079 | 0.604 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.165489 | 0.781 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.278343 | 0.555 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.153790 | 0.813 |
| R-HSA-210990 | PECAM1 interactions | 0.177026 | 0.752 |
| R-HSA-9635465 | Suppression of apoptosis | 0.177026 | 0.752 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.253463 | 0.596 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.193530 | 0.713 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.295555 | 0.529 |
| R-HSA-983712 | Ion channel transport | 0.165980 | 0.780 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.273974 | 0.562 |
| R-HSA-9834899 | Specification of the neural plate border | 0.284018 | 0.547 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.221610 | 0.654 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.201888 | 0.695 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.275976 | 0.559 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.177026 | 0.752 |
| R-HSA-8876725 | Protein methylation | 0.232376 | 0.634 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.178569 | 0.748 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.188524 | 0.725 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.173622 | 0.760 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.163884 | 0.785 |
| R-HSA-3371556 | Cellular response to heat stress | 0.290179 | 0.537 |
| R-HSA-9678110 | Attachment and Entry | 0.242992 | 0.614 |
| R-HSA-2028269 | Signaling by Hippo | 0.263789 | 0.579 |
| R-HSA-9629569 | Protein hydroxylation | 0.293923 | 0.532 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.213246 | 0.671 |
| R-HSA-8939211 | ESR-mediated signaling | 0.150884 | 0.821 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.265539 | 0.576 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.171296 | 0.766 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.236695 | 0.626 |
| R-HSA-177929 | Signaling by EGFR | 0.223878 | 0.650 |
| R-HSA-186712 | Regulation of beta-cell development | 0.239193 | 0.621 |
| R-HSA-2514856 | The phototransduction cascade | 0.198554 | 0.702 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.198348 | 0.703 |
| R-HSA-168268 | Virus Assembly and Release | 0.242992 | 0.614 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.163801 | 0.786 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.163801 | 0.786 |
| R-HSA-373755 | Semaphorin interactions | 0.259684 | 0.586 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.173998 | 0.759 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.170628 | 0.768 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.303693 | 0.518 |
| R-HSA-202040 | G-protein activation | 0.303693 | 0.518 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.303693 | 0.518 |
| R-HSA-167044 | Signalling to RAS | 0.303693 | 0.518 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.303693 | 0.518 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.303693 | 0.518 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.303693 | 0.518 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.303693 | 0.518 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.305770 | 0.515 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.310868 | 0.507 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.313327 | 0.504 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.313327 | 0.504 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.313327 | 0.504 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.313327 | 0.504 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.313327 | 0.504 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.313327 | 0.504 |
| R-HSA-9694614 | Attachment and Entry | 0.313327 | 0.504 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.315957 | 0.500 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.322829 | 0.491 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.322829 | 0.491 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.322829 | 0.491 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.322829 | 0.491 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.322829 | 0.491 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.322829 | 0.491 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.325607 | 0.487 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.326110 | 0.487 |
| R-HSA-1474165 | Reproduction | 0.331730 | 0.479 |
| R-HSA-913531 | Interferon Signaling | 0.332104 | 0.479 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.332200 | 0.479 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.332200 | 0.479 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.332200 | 0.479 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.332200 | 0.479 |
| R-HSA-3000170 | Syndecan interactions | 0.332200 | 0.479 |
| R-HSA-5619084 | ABC transporter disorders | 0.336224 | 0.473 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.336224 | 0.473 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.338133 | 0.471 |
| R-HSA-429947 | Deadenylation of mRNA | 0.341442 | 0.467 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.341442 | 0.467 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.341442 | 0.467 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.341442 | 0.467 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.341442 | 0.467 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.341442 | 0.467 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.341442 | 0.467 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.341442 | 0.467 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.341442 | 0.467 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.343071 | 0.465 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.344404 | 0.463 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.346293 | 0.461 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.346293 | 0.461 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.346293 | 0.461 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.350557 | 0.455 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.350557 | 0.455 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.350557 | 0.455 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.350557 | 0.455 |
| R-HSA-9620244 | Long-term potentiation | 0.350557 | 0.455 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.350557 | 0.455 |
| R-HSA-9839394 | TGFBR3 expression | 0.350557 | 0.455 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.350557 | 0.455 |
| R-HSA-3214842 | HDMs demethylate histones | 0.350557 | 0.455 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.358421 | 0.446 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.359546 | 0.444 |
| R-HSA-3295583 | TRP channels | 0.359546 | 0.444 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.359546 | 0.444 |
| R-HSA-525793 | Myogenesis | 0.359546 | 0.444 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.359546 | 0.444 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.359546 | 0.444 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.359546 | 0.444 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.363228 | 0.440 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.366275 | 0.436 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.368411 | 0.434 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.368411 | 0.434 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.368411 | 0.434 |
| R-HSA-1483213 | Synthesis of PE | 0.368411 | 0.434 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.368411 | 0.434 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.368411 | 0.434 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.368411 | 0.434 |
| R-HSA-112316 | Neuronal System | 0.371374 | 0.430 |
| R-HSA-9664407 | Parasite infection | 0.373218 | 0.428 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.373218 | 0.428 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.373218 | 0.428 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.376179 | 0.425 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.376970 | 0.424 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.377154 | 0.423 |
| R-HSA-77387 | Insulin receptor recycling | 0.377154 | 0.423 |
| R-HSA-9757110 | Prednisone ADME | 0.377154 | 0.423 |
| R-HSA-72172 | mRNA Splicing | 0.378903 | 0.421 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.381107 | 0.419 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.385776 | 0.414 |
| R-HSA-5334118 | DNA methylation | 0.385776 | 0.414 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.385776 | 0.414 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.385776 | 0.414 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.385776 | 0.414 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.385776 | 0.414 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.385776 | 0.414 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.385776 | 0.414 |
| R-HSA-418594 | G alpha (i) signalling events | 0.386146 | 0.413 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.388200 | 0.411 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.390914 | 0.408 |
| R-HSA-9663891 | Selective autophagy | 0.390914 | 0.408 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.394280 | 0.404 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.394280 | 0.404 |
| R-HSA-2424491 | DAP12 signaling | 0.394280 | 0.404 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.394280 | 0.404 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.394280 | 0.404 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.394280 | 0.404 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.394280 | 0.404 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.394280 | 0.404 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.394280 | 0.404 |
| R-HSA-73884 | Base Excision Repair | 0.400652 | 0.397 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.402525 | 0.395 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.402666 | 0.395 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.402666 | 0.395 |
| R-HSA-186763 | Downstream signal transduction | 0.402666 | 0.395 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.410316 | 0.387 |
| R-HSA-449147 | Signaling by Interleukins | 0.410711 | 0.386 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.410937 | 0.386 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.415119 | 0.382 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.419094 | 0.378 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.419094 | 0.378 |
| R-HSA-9930044 | Nuclear RNA decay | 0.419094 | 0.378 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.419094 | 0.378 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.419094 | 0.378 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.419094 | 0.378 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.419094 | 0.378 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.421570 | 0.375 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.424668 | 0.372 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.425242 | 0.371 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.427138 | 0.369 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.427138 | 0.369 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.427138 | 0.369 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.427138 | 0.369 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.427138 | 0.369 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.427138 | 0.369 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.427138 | 0.369 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.428907 | 0.368 |
| R-HSA-73887 | Death Receptor Signaling | 0.428907 | 0.368 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.434135 | 0.362 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.435071 | 0.361 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.435071 | 0.361 |
| R-HSA-392518 | Signal amplification | 0.435071 | 0.361 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.435071 | 0.361 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.435071 | 0.361 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.435071 | 0.361 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.435071 | 0.361 |
| R-HSA-5673000 | RAF activation | 0.435071 | 0.361 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.435071 | 0.361 |
| R-HSA-72766 | Translation | 0.435917 | 0.361 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.438838 | 0.358 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.438838 | 0.358 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.438838 | 0.358 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.442023 | 0.355 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.442895 | 0.354 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.442895 | 0.354 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.442895 | 0.354 |
| R-HSA-187687 | Signalling to ERKs | 0.442895 | 0.354 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.442895 | 0.354 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.442895 | 0.354 |
| R-HSA-157579 | Telomere Maintenance | 0.443519 | 0.353 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.448178 | 0.349 |
| R-HSA-190236 | Signaling by FGFR | 0.448178 | 0.349 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.450612 | 0.346 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.450612 | 0.346 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.450612 | 0.346 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.450612 | 0.346 |
| R-HSA-3371511 | HSF1 activation | 0.450612 | 0.346 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.450612 | 0.346 |
| R-HSA-3214847 | HATs acetylate histones | 0.452816 | 0.344 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.457432 | 0.340 |
| R-HSA-109581 | Apoptosis | 0.457908 | 0.339 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.458221 | 0.339 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.458221 | 0.339 |
| R-HSA-72312 | rRNA processing | 0.465398 | 0.332 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.465726 | 0.332 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.465726 | 0.332 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.473127 | 0.325 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.473127 | 0.325 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.473127 | 0.325 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.473127 | 0.325 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.480427 | 0.318 |
| R-HSA-202433 | Generation of second messenger molecules | 0.480427 | 0.318 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.480427 | 0.318 |
| R-HSA-9607240 | FLT3 Signaling | 0.487625 | 0.312 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.487625 | 0.312 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.487625 | 0.312 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.487625 | 0.312 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.487625 | 0.312 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.487625 | 0.312 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.487625 | 0.312 |
| R-HSA-9694548 | Maturation of spike protein | 0.487625 | 0.312 |
| R-HSA-157118 | Signaling by NOTCH | 0.489394 | 0.310 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.493256 | 0.307 |
| R-HSA-69239 | Synthesis of DNA | 0.493528 | 0.307 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.494724 | 0.306 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.494724 | 0.306 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.494724 | 0.306 |
| R-HSA-991365 | Activation of GABAB receptors | 0.501726 | 0.300 |
| R-HSA-977444 | GABA B receptor activation | 0.501726 | 0.300 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.501726 | 0.300 |
| R-HSA-165159 | MTOR signalling | 0.501726 | 0.300 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.501726 | 0.300 |
| R-HSA-74160 | Gene expression (Transcription) | 0.504512 | 0.297 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.508630 | 0.294 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.508630 | 0.294 |
| R-HSA-8854214 | TBC/RABGAPs | 0.508630 | 0.294 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.508630 | 0.294 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.508630 | 0.294 |
| R-HSA-2172127 | DAP12 interactions | 0.515440 | 0.288 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.515440 | 0.288 |
| R-HSA-373752 | Netrin-1 signaling | 0.515440 | 0.288 |
| R-HSA-69236 | G1 Phase | 0.515440 | 0.288 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.515440 | 0.288 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.515440 | 0.288 |
| R-HSA-168255 | Influenza Infection | 0.520702 | 0.283 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.522155 | 0.282 |
| R-HSA-774815 | Nucleosome assembly | 0.522155 | 0.282 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.522155 | 0.282 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.522155 | 0.282 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.528076 | 0.277 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.528778 | 0.277 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.528778 | 0.277 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.528778 | 0.277 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.528778 | 0.277 |
| R-HSA-5688426 | Deubiquitination | 0.533140 | 0.273 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.535310 | 0.271 |
| R-HSA-1483191 | Synthesis of PC | 0.535310 | 0.271 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.535991 | 0.271 |
| R-HSA-373760 | L1CAM interactions | 0.540617 | 0.267 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.541669 | 0.266 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.541751 | 0.266 |
| R-HSA-69275 | G2/M Transition | 0.544046 | 0.264 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.550595 | 0.259 |
| R-HSA-9679506 | SARS-CoV Infections | 0.551347 | 0.259 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.554368 | 0.256 |
| R-HSA-109704 | PI3K Cascade | 0.554368 | 0.256 |
| R-HSA-9748787 | Azathioprine ADME | 0.554368 | 0.256 |
| R-HSA-5617833 | Cilium Assembly | 0.557089 | 0.254 |
| R-HSA-416476 | G alpha (q) signalling events | 0.558487 | 0.253 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.560547 | 0.251 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.560547 | 0.251 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.560547 | 0.251 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.566640 | 0.247 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.566640 | 0.247 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.566640 | 0.247 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.566640 | 0.247 |
| R-HSA-109582 | Hemostasis | 0.567126 | 0.246 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.568974 | 0.245 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.572649 | 0.242 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.572649 | 0.242 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.572649 | 0.242 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.572921 | 0.242 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.572921 | 0.242 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.582564 | 0.235 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.584419 | 0.233 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.585768 | 0.232 |
| R-HSA-2262752 | Cellular responses to stress | 0.587662 | 0.231 |
| R-HSA-114608 | Platelet degranulation | 0.588447 | 0.230 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.590182 | 0.229 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.590182 | 0.229 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.590182 | 0.229 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.592262 | 0.227 |
| R-HSA-112399 | IRS-mediated signalling | 0.595866 | 0.225 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.601472 | 0.221 |
| R-HSA-5663205 | Infectious disease | 0.601946 | 0.220 |
| R-HSA-5357801 | Programmed Cell Death | 0.606967 | 0.217 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.607000 | 0.217 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.607000 | 0.217 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.610946 | 0.214 |
| R-HSA-9909396 | Circadian clock | 0.610946 | 0.214 |
| R-HSA-977443 | GABA receptor activation | 0.612451 | 0.213 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.612451 | 0.213 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.612451 | 0.213 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.612451 | 0.213 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.612451 | 0.213 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.612451 | 0.213 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.612451 | 0.213 |
| R-HSA-379724 | tRNA Aminoacylation | 0.612451 | 0.213 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.617828 | 0.209 |
| R-HSA-1268020 | Mitochondrial protein import | 0.623130 | 0.205 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.623130 | 0.205 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.623130 | 0.205 |
| R-HSA-186797 | Signaling by PDGF | 0.623130 | 0.205 |
| R-HSA-9707616 | Heme signaling | 0.623130 | 0.205 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.628359 | 0.202 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.628359 | 0.202 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.628359 | 0.202 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.628359 | 0.202 |
| R-HSA-211981 | Xenobiotics | 0.633515 | 0.198 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.633515 | 0.198 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.633515 | 0.198 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.633515 | 0.198 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.638601 | 0.195 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.638601 | 0.195 |
| R-HSA-6807070 | PTEN Regulation | 0.639475 | 0.194 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.643616 | 0.191 |
| R-HSA-1632852 | Macroautophagy | 0.646347 | 0.190 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.648562 | 0.188 |
| R-HSA-8951664 | Neddylation | 0.652998 | 0.185 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.662993 | 0.178 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.662993 | 0.178 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.662993 | 0.178 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.666571 | 0.176 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.667671 | 0.175 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.667671 | 0.175 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.669585 | 0.174 |
| R-HSA-2187338 | Visual phototransduction | 0.669585 | 0.174 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.671345 | 0.173 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.672285 | 0.172 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.672285 | 0.172 |
| R-HSA-74259 | Purine catabolism | 0.672285 | 0.172 |
| R-HSA-166520 | Signaling by NTRKs | 0.672802 | 0.172 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.676834 | 0.170 |
| R-HSA-9749641 | Aspirin ADME | 0.676834 | 0.170 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.681321 | 0.167 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.681321 | 0.167 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.682303 | 0.166 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.685420 | 0.164 |
| R-HSA-380287 | Centrosome maturation | 0.685746 | 0.164 |
| R-HSA-8852135 | Protein ubiquitination | 0.685746 | 0.164 |
| R-HSA-917937 | Iron uptake and transport | 0.685746 | 0.164 |
| R-HSA-9609507 | Protein localization | 0.688511 | 0.162 |
| R-HSA-69306 | DNA Replication | 0.688511 | 0.162 |
| R-HSA-5689603 | UCH proteinases | 0.690109 | 0.161 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.694413 | 0.158 |
| R-HSA-1989781 | PPARA activates gene expression | 0.694620 | 0.158 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.694620 | 0.158 |
| R-HSA-9612973 | Autophagy | 0.697637 | 0.156 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.697816 | 0.156 |
| R-HSA-4086400 | PCP/CE pathway | 0.698657 | 0.156 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.700630 | 0.155 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.702842 | 0.153 |
| R-HSA-877300 | Interferon gamma signaling | 0.706542 | 0.151 |
| R-HSA-6806834 | Signaling by MET | 0.706969 | 0.151 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.709461 | 0.149 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.711039 | 0.148 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.711039 | 0.148 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.711039 | 0.148 |
| R-HSA-199991 | Membrane Trafficking | 0.716053 | 0.145 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.719011 | 0.143 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.719352 | 0.143 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.722915 | 0.141 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.722915 | 0.141 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.726765 | 0.139 |
| R-HSA-9824446 | Viral Infection Pathways | 0.731995 | 0.135 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.734305 | 0.134 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.734305 | 0.134 |
| R-HSA-70268 | Pyruvate metabolism | 0.737997 | 0.132 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.741638 | 0.130 |
| R-HSA-382551 | Transport of small molecules | 0.742802 | 0.129 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.745229 | 0.128 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.747843 | 0.126 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.748770 | 0.126 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.748770 | 0.126 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.755705 | 0.122 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.759101 | 0.120 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.759101 | 0.120 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.765445 | 0.116 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.765753 | 0.116 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.772222 | 0.112 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.772534 | 0.112 |
| R-HSA-1296071 | Potassium Channels | 0.775389 | 0.110 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.778513 | 0.109 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.778513 | 0.109 |
| R-HSA-388396 | GPCR downstream signalling | 0.779951 | 0.108 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.781593 | 0.107 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.781593 | 0.107 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.781593 | 0.107 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.784630 | 0.105 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.784630 | 0.105 |
| R-HSA-392499 | Metabolism of proteins | 0.786813 | 0.104 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.790580 | 0.102 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.790580 | 0.102 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.792637 | 0.101 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.793493 | 0.100 |
| R-HSA-6798695 | Neutrophil degranulation | 0.796735 | 0.099 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.799199 | 0.097 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.804748 | 0.094 |
| R-HSA-418346 | Platelet homeostasis | 0.807465 | 0.093 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.809698 | 0.092 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.810144 | 0.091 |
| R-HSA-211000 | Gene Silencing by RNA | 0.810144 | 0.091 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.812786 | 0.090 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.812786 | 0.090 |
| R-HSA-1280218 | Adaptive Immune System | 0.813649 | 0.090 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.813697 | 0.090 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.815071 | 0.089 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.815392 | 0.089 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.815498 | 0.089 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.815668 | 0.088 |
| R-HSA-202403 | TCR signaling | 0.817961 | 0.087 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.817961 | 0.087 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.817961 | 0.087 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.817961 | 0.087 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.818913 | 0.087 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.822994 | 0.085 |
| R-HSA-6805567 | Keratinization | 0.823368 | 0.084 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.825458 | 0.083 |
| R-HSA-168256 | Immune System | 0.827083 | 0.082 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.832647 | 0.080 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.834978 | 0.078 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.834978 | 0.078 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.839542 | 0.076 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.839542 | 0.076 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.841777 | 0.075 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.843980 | 0.074 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.843980 | 0.074 |
| R-HSA-9748784 | Drug ADME | 0.844769 | 0.073 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.848296 | 0.071 |
| R-HSA-168249 | Innate Immune System | 0.849844 | 0.071 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.850410 | 0.070 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.850410 | 0.070 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.852494 | 0.069 |
| R-HSA-597592 | Post-translational protein modification | 0.857672 | 0.067 |
| R-HSA-69206 | G1/S Transition | 0.858574 | 0.066 |
| R-HSA-1643685 | Disease | 0.861936 | 0.065 |
| R-HSA-69481 | G2/M Checkpoints | 0.862488 | 0.064 |
| R-HSA-372790 | Signaling by GPCR | 0.865592 | 0.063 |
| R-HSA-8956319 | Nucleotide catabolism | 0.866294 | 0.062 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.868158 | 0.061 |
| R-HSA-15869 | Metabolism of nucleotides | 0.872494 | 0.059 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.879513 | 0.056 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.885429 | 0.053 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.888911 | 0.051 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.893201 | 0.049 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.894691 | 0.048 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.899038 | 0.046 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.899702 | 0.046 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.901836 | 0.045 |
| R-HSA-9758941 | Gastrulation | 0.903206 | 0.044 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.904558 | 0.044 |
| R-HSA-9610379 | HCMV Late Events | 0.913504 | 0.039 |
| R-HSA-9711097 | Cellular response to starvation | 0.914712 | 0.039 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.924855 | 0.034 |
| R-HSA-5619102 | SLC transporter disorders | 0.924855 | 0.034 |
| R-HSA-72306 | tRNA processing | 0.928968 | 0.032 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.933796 | 0.030 |
| R-HSA-1483257 | Phospholipid metabolism | 0.934525 | 0.029 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.947156 | 0.024 |
| R-HSA-9609690 | HCMV Early Events | 0.950752 | 0.022 |
| R-HSA-8957322 | Metabolism of steroids | 0.953292 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.954105 | 0.020 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.955381 | 0.020 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.969089 | 0.014 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.969950 | 0.013 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.972780 | 0.012 |
| R-HSA-212436 | Generic Transcription Pathway | 0.976314 | 0.010 |
| R-HSA-9609646 | HCMV Infection | 0.977352 | 0.010 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.984765 | 0.007 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.993773 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.995512 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.996946 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997116 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997237 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997605 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998067 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998281 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999546 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999680 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.851 | 0.241 | 2 | 0.844 |
CLK3 |
0.841 | 0.168 | 1 | 0.820 |
DSTYK |
0.840 | 0.195 | 2 | 0.884 |
BMPR1B |
0.838 | 0.334 | 1 | 0.826 |
CDC7 |
0.836 | 0.089 | 1 | 0.879 |
MOS |
0.836 | 0.163 | 1 | 0.878 |
FAM20C |
0.832 | 0.187 | 2 | 0.656 |
IKKA |
0.831 | 0.166 | -2 | 0.696 |
IKKB |
0.830 | 0.034 | -2 | 0.705 |
BMPR1A |
0.829 | 0.360 | 1 | 0.816 |
GRK1 |
0.828 | 0.132 | -2 | 0.730 |
NEK6 |
0.827 | 0.084 | -2 | 0.822 |
CAMK2G |
0.827 | 0.042 | 2 | 0.794 |
TGFBR1 |
0.827 | 0.277 | -2 | 0.843 |
GRK6 |
0.827 | 0.173 | 1 | 0.843 |
PIM3 |
0.826 | 0.012 | -3 | 0.633 |
GCN2 |
0.826 | 0.023 | 2 | 0.761 |
PRPK |
0.826 | -0.049 | -1 | 0.818 |
RAF1 |
0.825 | -0.010 | 1 | 0.841 |
GRK7 |
0.824 | 0.212 | 1 | 0.759 |
BMPR2 |
0.823 | 0.065 | -2 | 0.847 |
MTOR |
0.823 | -0.037 | 1 | 0.758 |
TBK1 |
0.821 | -0.000 | 1 | 0.735 |
ALK2 |
0.821 | 0.287 | -2 | 0.843 |
NEK7 |
0.821 | 0.007 | -3 | 0.644 |
ATR |
0.821 | 0.011 | 1 | 0.828 |
GRK5 |
0.820 | 0.011 | -3 | 0.681 |
MLK1 |
0.820 | 0.080 | 2 | 0.837 |
TGFBR2 |
0.820 | 0.081 | -2 | 0.814 |
ATM |
0.820 | 0.105 | 1 | 0.785 |
CAMK1B |
0.819 | -0.051 | -3 | 0.659 |
ALK4 |
0.819 | 0.220 | -2 | 0.859 |
ACVR2B |
0.819 | 0.239 | -2 | 0.816 |
PKN3 |
0.819 | -0.001 | -3 | 0.620 |
ACVR2A |
0.819 | 0.232 | -2 | 0.805 |
IKKE |
0.819 | -0.007 | 1 | 0.731 |
ULK2 |
0.818 | -0.100 | 2 | 0.755 |
PIM1 |
0.817 | 0.019 | -3 | 0.584 |
PDHK4 |
0.817 | -0.214 | 1 | 0.839 |
NLK |
0.817 | -0.040 | 1 | 0.792 |
MST4 |
0.816 | 0.029 | 2 | 0.890 |
PKCD |
0.816 | 0.060 | 2 | 0.835 |
NDR2 |
0.816 | -0.057 | -3 | 0.628 |
PLK3 |
0.815 | 0.236 | 2 | 0.716 |
GRK4 |
0.815 | 0.054 | -2 | 0.772 |
RSK2 |
0.815 | -0.012 | -3 | 0.574 |
MLK3 |
0.815 | 0.120 | 2 | 0.807 |
KIS |
0.815 | 0.042 | 1 | 0.642 |
PRKD1 |
0.814 | -0.038 | -3 | 0.595 |
CDKL1 |
0.814 | -0.051 | -3 | 0.600 |
CAMK2B |
0.813 | 0.059 | 2 | 0.763 |
SKMLCK |
0.813 | -0.029 | -2 | 0.813 |
PRKD2 |
0.813 | -0.021 | -3 | 0.560 |
PLK1 |
0.813 | 0.093 | -2 | 0.774 |
NIK |
0.812 | -0.074 | -3 | 0.679 |
ERK5 |
0.812 | -0.039 | 1 | 0.732 |
PLK2 |
0.812 | 0.400 | -3 | 0.894 |
CK2A2 |
0.811 | 0.259 | 1 | 0.765 |
PDHK1 |
0.811 | -0.189 | 1 | 0.823 |
MARK4 |
0.811 | -0.046 | 4 | 0.879 |
NUAK2 |
0.810 | -0.062 | -3 | 0.632 |
MLK4 |
0.810 | 0.137 | 2 | 0.752 |
CHAK2 |
0.810 | -0.044 | -1 | 0.804 |
ULK1 |
0.809 | -0.115 | -3 | 0.634 |
PKN2 |
0.809 | -0.041 | -3 | 0.619 |
HUNK |
0.808 | -0.102 | 2 | 0.723 |
CAMLCK |
0.808 | -0.076 | -2 | 0.811 |
DAPK2 |
0.807 | -0.090 | -3 | 0.655 |
SRPK1 |
0.806 | -0.023 | -3 | 0.549 |
P70S6KB |
0.806 | -0.052 | -3 | 0.595 |
ANKRD3 |
0.806 | -0.048 | 1 | 0.827 |
PKR |
0.806 | 0.062 | 1 | 0.818 |
MAPKAPK2 |
0.806 | -0.026 | -3 | 0.534 |
TSSK2 |
0.805 | -0.029 | -5 | 0.721 |
CAMK2A |
0.805 | 0.012 | 2 | 0.776 |
CDK8 |
0.805 | -0.005 | 1 | 0.629 |
WNK1 |
0.805 | -0.119 | -2 | 0.811 |
SRPK2 |
0.805 | -0.008 | -3 | 0.493 |
BCKDK |
0.805 | -0.118 | -1 | 0.784 |
TLK2 |
0.805 | 0.098 | 1 | 0.799 |
NEK9 |
0.805 | -0.103 | 2 | 0.824 |
NDR1 |
0.805 | -0.104 | -3 | 0.625 |
LATS1 |
0.805 | 0.016 | -3 | 0.642 |
P90RSK |
0.804 | -0.071 | -3 | 0.575 |
CAMK2D |
0.804 | -0.098 | -3 | 0.620 |
PRKX |
0.804 | 0.051 | -3 | 0.492 |
RIPK3 |
0.804 | -0.156 | 3 | 0.722 |
DLK |
0.804 | -0.105 | 1 | 0.815 |
AMPKA1 |
0.803 | -0.092 | -3 | 0.638 |
RSK3 |
0.803 | -0.062 | -3 | 0.582 |
CDKL5 |
0.803 | -0.070 | -3 | 0.586 |
GRK2 |
0.803 | 0.057 | -2 | 0.693 |
PKACG |
0.802 | -0.044 | -2 | 0.737 |
AURC |
0.802 | -0.009 | -2 | 0.659 |
CDK1 |
0.801 | 0.040 | 1 | 0.599 |
RSK4 |
0.801 | -0.008 | -3 | 0.548 |
LATS2 |
0.801 | -0.091 | -5 | 0.637 |
HIPK4 |
0.801 | -0.070 | 1 | 0.745 |
ICK |
0.801 | -0.079 | -3 | 0.620 |
PKCB |
0.801 | 0.025 | 2 | 0.803 |
TSSK1 |
0.801 | -0.045 | -3 | 0.656 |
MAPKAPK3 |
0.800 | -0.108 | -3 | 0.563 |
TTBK2 |
0.800 | -0.100 | 2 | 0.671 |
MLK2 |
0.800 | -0.099 | 2 | 0.815 |
YSK4 |
0.800 | -0.001 | 1 | 0.760 |
IRE2 |
0.800 | 0.004 | 2 | 0.767 |
CLK2 |
0.799 | 0.046 | -3 | 0.565 |
DNAPK |
0.799 | 0.039 | 1 | 0.726 |
PKACB |
0.799 | 0.001 | -2 | 0.678 |
PKCA |
0.798 | 0.019 | 2 | 0.801 |
WNK3 |
0.798 | -0.239 | 1 | 0.794 |
JNK3 |
0.798 | 0.036 | 1 | 0.613 |
CDK5 |
0.798 | 0.031 | 1 | 0.653 |
BRAF |
0.797 | 0.037 | -4 | 0.785 |
CK2A1 |
0.797 | 0.211 | 1 | 0.744 |
CLK4 |
0.797 | -0.019 | -3 | 0.571 |
PKCG |
0.797 | -0.005 | 2 | 0.801 |
NEK2 |
0.796 | -0.071 | 2 | 0.816 |
CDK19 |
0.796 | -0.020 | 1 | 0.590 |
AMPKA2 |
0.796 | -0.099 | -3 | 0.608 |
JNK2 |
0.796 | 0.036 | 1 | 0.580 |
IRE1 |
0.795 | -0.103 | 1 | 0.758 |
AURA |
0.795 | 0.005 | -2 | 0.604 |
PAK1 |
0.795 | -0.073 | -2 | 0.734 |
SRPK3 |
0.795 | -0.039 | -3 | 0.534 |
PRKD3 |
0.795 | -0.070 | -3 | 0.541 |
QSK |
0.795 | -0.062 | 4 | 0.852 |
MSK2 |
0.794 | -0.086 | -3 | 0.539 |
MEK1 |
0.794 | -0.134 | 2 | 0.773 |
SIK |
0.794 | -0.067 | -3 | 0.562 |
CLK1 |
0.794 | -0.015 | -3 | 0.553 |
GRK3 |
0.794 | 0.064 | -2 | 0.654 |
PINK1 |
0.793 | -0.049 | 1 | 0.792 |
MARK2 |
0.793 | -0.029 | 4 | 0.788 |
TLK1 |
0.793 | 0.043 | -2 | 0.822 |
CK1E |
0.793 | -0.038 | -3 | 0.425 |
PKCH |
0.793 | -0.023 | 2 | 0.771 |
MARK3 |
0.793 | -0.035 | 4 | 0.820 |
AURB |
0.793 | -0.032 | -2 | 0.646 |
CAMK4 |
0.792 | -0.143 | -3 | 0.614 |
MSK1 |
0.792 | -0.047 | -3 | 0.545 |
MASTL |
0.792 | -0.333 | -2 | 0.743 |
NIM1 |
0.792 | -0.150 | 3 | 0.766 |
CHK1 |
0.792 | -0.050 | -3 | 0.657 |
NUAK1 |
0.792 | -0.106 | -3 | 0.595 |
DRAK1 |
0.791 | -0.046 | 1 | 0.783 |
SMG1 |
0.790 | -0.059 | 1 | 0.782 |
RIPK1 |
0.790 | -0.273 | 1 | 0.782 |
P38G |
0.790 | 0.026 | 1 | 0.503 |
PERK |
0.790 | -0.036 | -2 | 0.811 |
MEKK2 |
0.790 | 0.024 | 2 | 0.781 |
BRSK1 |
0.790 | -0.084 | -3 | 0.589 |
QIK |
0.790 | -0.151 | -3 | 0.618 |
MEKK1 |
0.790 | -0.025 | 1 | 0.783 |
AKT2 |
0.790 | -0.041 | -3 | 0.502 |
PRP4 |
0.790 | -0.013 | -3 | 0.603 |
VRK2 |
0.789 | -0.267 | 1 | 0.834 |
CHAK1 |
0.789 | -0.115 | 2 | 0.753 |
ERK1 |
0.789 | 0.006 | 1 | 0.566 |
MEKK3 |
0.789 | -0.056 | 1 | 0.780 |
CDK2 |
0.789 | -0.020 | 1 | 0.678 |
PKG2 |
0.789 | -0.033 | -2 | 0.694 |
TAO3 |
0.789 | 0.027 | 1 | 0.776 |
MYLK4 |
0.789 | -0.082 | -2 | 0.742 |
SGK3 |
0.789 | -0.045 | -3 | 0.554 |
DYRK2 |
0.788 | -0.052 | 1 | 0.643 |
P38A |
0.788 | -0.006 | 1 | 0.642 |
MNK2 |
0.788 | -0.092 | -2 | 0.759 |
CDK13 |
0.788 | -0.041 | 1 | 0.606 |
MELK |
0.787 | -0.146 | -3 | 0.591 |
PIM2 |
0.787 | -0.057 | -3 | 0.551 |
PKCZ |
0.787 | -0.082 | 2 | 0.801 |
PHKG1 |
0.787 | -0.105 | -3 | 0.612 |
GSK3A |
0.787 | 0.067 | 4 | 0.520 |
PAK3 |
0.787 | -0.141 | -2 | 0.735 |
NEK5 |
0.786 | -0.065 | 1 | 0.802 |
HRI |
0.786 | -0.101 | -2 | 0.823 |
MST2 |
0.786 | 0.112 | 1 | 0.804 |
MARK1 |
0.786 | -0.070 | 4 | 0.841 |
ERK2 |
0.786 | -0.020 | 1 | 0.616 |
CDK18 |
0.785 | -0.016 | 1 | 0.560 |
P38B |
0.784 | -0.005 | 1 | 0.573 |
MNK1 |
0.784 | -0.089 | -2 | 0.778 |
CK1D |
0.784 | -0.049 | -3 | 0.368 |
HIPK2 |
0.784 | -0.016 | 1 | 0.555 |
ZAK |
0.783 | -0.080 | 1 | 0.752 |
PKACA |
0.783 | -0.019 | -2 | 0.646 |
CDK3 |
0.783 | 0.019 | 1 | 0.531 |
CDK7 |
0.783 | -0.081 | 1 | 0.636 |
PAK2 |
0.783 | -0.129 | -2 | 0.714 |
NEK8 |
0.783 | -0.026 | 2 | 0.826 |
MST3 |
0.783 | -0.026 | 2 | 0.858 |
P38D |
0.782 | 0.027 | 1 | 0.524 |
PAK6 |
0.782 | -0.080 | -2 | 0.663 |
CDK17 |
0.782 | -0.017 | 1 | 0.513 |
PASK |
0.781 | -0.042 | -3 | 0.639 |
DCAMKL1 |
0.781 | -0.102 | -3 | 0.584 |
HIPK1 |
0.781 | -0.045 | 1 | 0.658 |
CAMK1G |
0.781 | -0.116 | -3 | 0.559 |
CAMKK1 |
0.780 | -0.096 | -2 | 0.724 |
MEK5 |
0.779 | -0.229 | 2 | 0.788 |
CK1G1 |
0.779 | -0.073 | -3 | 0.420 |
EEF2K |
0.779 | 0.054 | 3 | 0.812 |
AKT1 |
0.779 | -0.046 | -3 | 0.509 |
TAK1 |
0.779 | 0.026 | 1 | 0.829 |
SMMLCK |
0.779 | -0.095 | -3 | 0.608 |
GAK |
0.779 | -0.018 | 1 | 0.805 |
CDK12 |
0.779 | -0.048 | 1 | 0.579 |
CK1A2 |
0.778 | -0.060 | -3 | 0.369 |
BRSK2 |
0.778 | -0.165 | -3 | 0.603 |
PLK4 |
0.777 | -0.143 | 2 | 0.566 |
PKCT |
0.777 | -0.059 | 2 | 0.779 |
GCK |
0.777 | 0.007 | 1 | 0.807 |
TAO2 |
0.777 | -0.048 | 2 | 0.871 |
GSK3B |
0.777 | -0.000 | 4 | 0.509 |
CAMK1D |
0.777 | -0.076 | -3 | 0.509 |
CDK16 |
0.777 | 0.008 | 1 | 0.530 |
SSTK |
0.777 | -0.077 | 4 | 0.842 |
JNK1 |
0.776 | 0.017 | 1 | 0.572 |
DAPK3 |
0.776 | -0.047 | -3 | 0.593 |
ERK7 |
0.775 | 0.042 | 2 | 0.628 |
MAPKAPK5 |
0.775 | -0.190 | -3 | 0.516 |
DYRK1A |
0.775 | -0.079 | 1 | 0.691 |
DCAMKL2 |
0.775 | -0.105 | -3 | 0.610 |
CDK9 |
0.774 | -0.084 | 1 | 0.611 |
P70S6K |
0.774 | -0.108 | -3 | 0.514 |
SNRK |
0.773 | -0.245 | 2 | 0.651 |
TNIK |
0.773 | 0.012 | 3 | 0.819 |
CAMKK2 |
0.773 | -0.134 | -2 | 0.723 |
MST1 |
0.772 | 0.023 | 1 | 0.783 |
IRAK4 |
0.772 | -0.184 | 1 | 0.764 |
WNK4 |
0.772 | -0.204 | -2 | 0.796 |
PKCE |
0.772 | -0.016 | 2 | 0.792 |
DYRK4 |
0.772 | -0.039 | 1 | 0.574 |
MINK |
0.771 | -0.027 | 1 | 0.785 |
PHKG2 |
0.771 | -0.113 | -3 | 0.593 |
DYRK1B |
0.771 | -0.056 | 1 | 0.609 |
TTBK1 |
0.770 | -0.156 | 2 | 0.595 |
SGK1 |
0.770 | -0.030 | -3 | 0.436 |
PKCI |
0.770 | -0.078 | 2 | 0.785 |
HGK |
0.770 | -0.048 | 3 | 0.818 |
DAPK1 |
0.769 | -0.057 | -3 | 0.576 |
CDK14 |
0.769 | -0.057 | 1 | 0.607 |
HIPK3 |
0.768 | -0.093 | 1 | 0.648 |
LKB1 |
0.768 | -0.166 | -3 | 0.630 |
NEK11 |
0.768 | -0.192 | 1 | 0.779 |
SLK |
0.768 | -0.036 | -2 | 0.671 |
NEK4 |
0.767 | -0.144 | 1 | 0.774 |
PDK1 |
0.767 | -0.138 | 1 | 0.773 |
TTK |
0.767 | 0.118 | -2 | 0.789 |
MPSK1 |
0.767 | -0.129 | 1 | 0.741 |
AKT3 |
0.766 | -0.045 | -3 | 0.442 |
CDK10 |
0.766 | -0.033 | 1 | 0.594 |
HPK1 |
0.766 | -0.056 | 1 | 0.789 |
DYRK3 |
0.766 | -0.079 | 1 | 0.657 |
KHS2 |
0.766 | 0.018 | 1 | 0.796 |
LOK |
0.765 | -0.067 | -2 | 0.732 |
KHS1 |
0.763 | -0.020 | 1 | 0.777 |
ROCK2 |
0.763 | -0.045 | -3 | 0.578 |
MRCKB |
0.763 | -0.056 | -3 | 0.539 |
CAMK1A |
0.762 | -0.084 | -3 | 0.470 |
LRRK2 |
0.762 | -0.177 | 2 | 0.838 |
PKN1 |
0.762 | -0.086 | -3 | 0.522 |
MAP3K15 |
0.762 | -0.149 | 1 | 0.731 |
NEK1 |
0.762 | -0.150 | 1 | 0.768 |
CHK2 |
0.762 | -0.098 | -3 | 0.456 |
ALPHAK3 |
0.761 | 0.079 | -1 | 0.749 |
MRCKA |
0.760 | -0.073 | -3 | 0.557 |
OSR1 |
0.760 | 0.022 | 2 | 0.769 |
CDK6 |
0.760 | -0.031 | 1 | 0.581 |
VRK1 |
0.760 | -0.176 | 2 | 0.794 |
PDHK3_TYR |
0.760 | 0.099 | 4 | 0.930 |
PAK5 |
0.759 | -0.118 | -2 | 0.595 |
IRAK1 |
0.759 | -0.302 | -1 | 0.715 |
BUB1 |
0.757 | -0.037 | -5 | 0.667 |
YSK1 |
0.757 | -0.082 | 2 | 0.829 |
MEKK6 |
0.757 | -0.210 | 1 | 0.754 |
SBK |
0.756 | -0.077 | -3 | 0.406 |
MAK |
0.756 | -0.048 | -2 | 0.681 |
PAK4 |
0.756 | -0.108 | -2 | 0.599 |
CDK4 |
0.755 | -0.049 | 1 | 0.568 |
MEK2 |
0.754 | -0.220 | 2 | 0.746 |
PDHK4_TYR |
0.754 | 0.065 | 2 | 0.838 |
CK1A |
0.753 | -0.051 | -3 | 0.297 |
PDHK1_TYR |
0.753 | 0.118 | -1 | 0.877 |
DMPK1 |
0.753 | -0.048 | -3 | 0.561 |
MAP2K6_TYR |
0.752 | 0.068 | -1 | 0.855 |
BMPR2_TYR |
0.751 | 0.064 | -1 | 0.837 |
STK33 |
0.751 | -0.192 | 2 | 0.584 |
ROCK1 |
0.749 | -0.060 | -3 | 0.553 |
MYO3A |
0.748 | -0.022 | 1 | 0.771 |
TESK1_TYR |
0.748 | -0.092 | 3 | 0.854 |
MAP2K4_TYR |
0.748 | -0.041 | -1 | 0.844 |
PBK |
0.748 | -0.115 | 1 | 0.717 |
HASPIN |
0.748 | -0.037 | -1 | 0.659 |
MYO3B |
0.747 | -0.047 | 2 | 0.850 |
RIPK2 |
0.746 | -0.279 | 1 | 0.719 |
EPHA6 |
0.746 | 0.071 | -1 | 0.837 |
MOK |
0.746 | -0.091 | 1 | 0.652 |
PKG1 |
0.746 | -0.077 | -2 | 0.632 |
MAP2K7_TYR |
0.745 | -0.148 | 2 | 0.824 |
TXK |
0.745 | 0.181 | 1 | 0.840 |
PINK1_TYR |
0.745 | -0.067 | 1 | 0.808 |
CRIK |
0.744 | -0.079 | -3 | 0.504 |
NEK3 |
0.743 | -0.216 | 1 | 0.717 |
EPHB4 |
0.742 | 0.057 | -1 | 0.823 |
YANK3 |
0.742 | -0.078 | 2 | 0.388 |
TAO1 |
0.742 | -0.088 | 1 | 0.702 |
BIKE |
0.740 | -0.056 | 1 | 0.673 |
PKMYT1_TYR |
0.740 | -0.182 | 3 | 0.820 |
ASK1 |
0.739 | -0.179 | 1 | 0.720 |
RET |
0.739 | -0.023 | 1 | 0.763 |
INSRR |
0.738 | 0.058 | 3 | 0.727 |
FER |
0.738 | 0.038 | 1 | 0.857 |
EPHA4 |
0.737 | 0.040 | 2 | 0.726 |
YES1 |
0.737 | 0.078 | -1 | 0.796 |
CK1G3 |
0.737 | -0.046 | -3 | 0.253 |
BLK |
0.736 | 0.135 | -1 | 0.803 |
ABL2 |
0.736 | 0.051 | -1 | 0.787 |
EPHB2 |
0.735 | 0.087 | -1 | 0.814 |
CSF1R |
0.735 | 0.018 | 3 | 0.757 |
ROS1 |
0.735 | -0.063 | 3 | 0.742 |
SRMS |
0.734 | 0.059 | 1 | 0.844 |
LIMK2_TYR |
0.734 | -0.167 | -3 | 0.679 |
TYK2 |
0.734 | -0.126 | 1 | 0.761 |
EPHB1 |
0.733 | 0.014 | 1 | 0.830 |
LCK |
0.733 | 0.085 | -1 | 0.785 |
TYRO3 |
0.733 | -0.093 | 3 | 0.768 |
FGR |
0.732 | -0.018 | 1 | 0.814 |
MST1R |
0.732 | -0.135 | 3 | 0.774 |
STLK3 |
0.731 | -0.149 | 1 | 0.727 |
LIMK1_TYR |
0.731 | -0.223 | 2 | 0.839 |
HCK |
0.731 | 0.006 | -1 | 0.780 |
FYN |
0.731 | 0.132 | -1 | 0.754 |
JAK2 |
0.731 | -0.114 | 1 | 0.753 |
EPHB3 |
0.730 | -0.009 | -1 | 0.811 |
JAK3 |
0.729 | -0.063 | 1 | 0.746 |
ABL1 |
0.728 | -0.001 | -1 | 0.773 |
KIT |
0.728 | -0.021 | 3 | 0.762 |
ITK |
0.727 | -0.014 | -1 | 0.753 |
DDR1 |
0.727 | -0.191 | 4 | 0.854 |
FLT3 |
0.727 | -0.018 | 3 | 0.757 |
TEC |
0.727 | 0.019 | -1 | 0.688 |
PDGFRB |
0.727 | -0.071 | 3 | 0.771 |
FGFR2 |
0.726 | -0.052 | 3 | 0.770 |
EPHA7 |
0.725 | 0.010 | 2 | 0.731 |
KDR |
0.724 | -0.057 | 3 | 0.722 |
FLT1 |
0.724 | 0.007 | -1 | 0.834 |
BMX |
0.723 | -0.016 | -1 | 0.674 |
EPHA5 |
0.723 | 0.055 | 2 | 0.712 |
TNNI3K_TYR |
0.722 | -0.062 | 1 | 0.766 |
SYK |
0.722 | 0.106 | -1 | 0.762 |
FRK |
0.722 | 0.041 | -1 | 0.820 |
MERTK |
0.722 | -0.046 | 3 | 0.744 |
EGFR |
0.721 | 0.052 | 1 | 0.640 |
EPHA8 |
0.721 | 0.060 | -1 | 0.793 |
ERBB2 |
0.721 | -0.035 | 1 | 0.735 |
MET |
0.721 | -0.036 | 3 | 0.744 |
AAK1 |
0.721 | -0.035 | 1 | 0.562 |
JAK1 |
0.720 | -0.068 | 1 | 0.710 |
LYN |
0.720 | 0.046 | 3 | 0.690 |
ALK |
0.720 | -0.063 | 3 | 0.692 |
NTRK1 |
0.720 | -0.066 | -1 | 0.795 |
PTK2 |
0.720 | 0.070 | -1 | 0.746 |
BTK |
0.720 | -0.073 | -1 | 0.709 |
EPHA3 |
0.719 | -0.072 | 2 | 0.706 |
PTK6 |
0.719 | -0.059 | -1 | 0.679 |
FGFR1 |
0.719 | -0.112 | 3 | 0.744 |
NEK10_TYR |
0.719 | -0.124 | 1 | 0.652 |
LTK |
0.719 | -0.068 | 3 | 0.712 |
MATK |
0.718 | -0.007 | -1 | 0.736 |
TNK2 |
0.718 | -0.159 | 3 | 0.716 |
FGFR3 |
0.718 | -0.036 | 3 | 0.743 |
TEK |
0.717 | -0.150 | 3 | 0.711 |
CK1G2 |
0.717 | -0.045 | -3 | 0.343 |
AXL |
0.717 | -0.134 | 3 | 0.749 |
PDGFRA |
0.717 | -0.161 | 3 | 0.767 |
INSR |
0.716 | -0.067 | 3 | 0.701 |
SRC |
0.715 | 0.046 | -1 | 0.753 |
WEE1_TYR |
0.715 | -0.114 | -1 | 0.702 |
FGFR4 |
0.715 | 0.038 | -1 | 0.761 |
CSK |
0.715 | 0.036 | 2 | 0.732 |
FLT4 |
0.715 | -0.083 | 3 | 0.724 |
NTRK2 |
0.714 | -0.101 | 3 | 0.723 |
NTRK3 |
0.712 | -0.064 | -1 | 0.752 |
TNK1 |
0.712 | -0.201 | 3 | 0.747 |
PTK2B |
0.711 | -0.042 | -1 | 0.732 |
YANK2 |
0.710 | -0.093 | 2 | 0.405 |
EPHA1 |
0.710 | -0.125 | 3 | 0.727 |
EPHA2 |
0.708 | 0.009 | -1 | 0.757 |
DDR2 |
0.706 | -0.120 | 3 | 0.710 |
ERBB4 |
0.706 | 0.015 | 1 | 0.681 |
IGF1R |
0.705 | -0.042 | 3 | 0.648 |
MUSK |
0.695 | -0.112 | 1 | 0.620 |
ZAP70 |
0.687 | -0.035 | -1 | 0.665 |
FES |
0.686 | -0.092 | -1 | 0.648 |