Motif 60 (n=274)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S237 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A5PKW4 | PSD | S133 | ochoa | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) | Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}. |
| A6NC98 | CCDC88B | S514 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A8K0R7 | ZNF839 | S670 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| A9YTQ3 | AHRR | S101 | ochoa | Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77) | Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}. |
| B7Z6K7 | ZNF814 | S87 | ochoa | Zinc finger protein 814 | None |
| B8ZZF3 | None | S240 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| M0QZK8 | None | S51 | ochoa | gamma-glutamylcyclotransferase (EC 4.3.2.9) | None |
| O00141 | SGK1 | S401 | ochoa | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}. |
| O00418 | EEF2K | S627 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14578 | CIT | S440 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14795 | UNC13B | S367 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15014 | ZNF609 | S804 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15075 | DCLK1 | S32 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15231 | ZNF185 | S307 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43237 | DYNC1LI2 | S194 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43294 | TGFB1I1 | S68 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43314 | PPIP5K2 | S1172 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43379 | WDR62 | S1325 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43502 | RAD51C | S20 | ochoa | DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) | Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:16395335, ECO:0000269|PubMed:19451272, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}. |
| O43602 | DCX | S28 | ochoa|psp | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| O43660 | PLRG1 | S391 | ochoa | Pleiotropic regulator 1 | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| O43711 | TLX3 | S26 | ochoa | T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2) | None |
| O60336 | MAPKBP1 | S1216 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O75223 | GGCT | S136 | ochoa | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
| O75362 | ZNF217 | S253 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75376 | NCOR1 | S158 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75643 | SNRNP200 | S835 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75832 | PSMD10 | S75 | ochoa | 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
| O75970 | MPDZ | S483 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O76080 | ZFAND5 | S128 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94804 | STK10 | S392 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94967 | WDR47 | S374 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95049 | TJP3 | S378 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95382 | MAP3K6 | S1144 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95402 | MED26 | S232 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O96008 | TOMM40 | S142 | ochoa | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022}. |
| P02511 | CRYAB | S19 | ochoa|psp | Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component) | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P23927}. |
| P07814 | EPRS1 | S886 | ochoa|psp | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P10075 | GLI4 | S86 | ochoa | Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4) | None |
| P10244 | MYBL2 | S282 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P10588 | NR2F6 | S34 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
| P11137 | MAP2 | S788 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P13716 | ALAD | S215 | ochoa | Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) | Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000269|PubMed:11032836, ECO:0000269|PubMed:19812033}. |
| P16157 | ANK1 | S759 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17542 | TAL1 | S122 | ochoa|psp | T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5) | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. |
| P18206 | VCL | S795 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19174 | PLCG1 | S1221 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P19484 | TFEB | S332 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P22736 | NR4A1 | S152 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P26232 | CTNNA2 | S262 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27105 | STOM | S22 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
| P27987 | ITPKB | S120 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30050 | RPL12 | S38 | ochoa|psp | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P30305 | CDC25B | S465 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31260 | HOXA10 | S313 | ochoa | Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
| P35520 | CBS | S63 | ochoa | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P37837 | TALDO1 | S256 | ochoa | Transaldolase (EC 2.2.1.2) | Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}. |
| P41229 | KDM5C | S1359 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P42229 | STAT5A | S193 | ochoa | Signal transducer and activator of transcription 5A | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}. |
| P42345 | MTOR | S1166 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42892 | ECE1 | S51 | ochoa | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) | Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:37835445, ECO:0000269|PubMed:9396733}. |
| P43358 | MAGEA4 | S99 | ochoa | Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen) | Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486). {ECO:0000269|PubMed:22842486}. |
| P46013 | MKI67 | S2528 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46531 | NOTCH1 | S2121 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P48552 | NRIP1 | S252 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48552 | NRIP1 | S1011 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48553 | TRAPPC10 | S573 | ochoa | Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) | Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. {ECO:0000269|PubMed:11805826, ECO:0000269|PubMed:31467083, ECO:0000269|PubMed:35298461}. |
| P48637 | GSS | S137 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P49006 | MARCKSL1 | S22 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49790 | NUP153 | S522 | ochoa|psp | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49796 | RGS3 | S704 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P49815 | TSC2 | S1217 | psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50851 | LRBA | S1488 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51003 | PAPOLA | S24 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51692 | STAT5B | S193 | ochoa|psp | Signal transducer and activator of transcription 5B | Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:29844444, ECO:0000269|PubMed:8732682}. |
| P51946 | CCNH | S132 | ochoa | Cyclin-H (MO15-associated protein) (p34) (p37) | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}. |
| P52701 | MSH6 | S91 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P52948 | NUP98 | S1099 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P53814 | SMTN | S341 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54278 | PMS2 | S436 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P55196 | AFDN | S1779 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57059 | SIK1 | S534 | ochoa | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| P78362 | SRPK2 | S380 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| P85037 | FOXK1 | S472 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01484 | ANK2 | S1755 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q04725 | TLE2 | S271 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q04726 | TLE3 | S286 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q04727 | TLE4 | S292 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q05932 | FPGS | S539 | ochoa | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}. |
| Q08050 | FOXM1 | S331 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q09666 | AHNAK | S2397 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5099 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0VF96 | CGNL1 | S112 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12852 | MAP3K12 | S500 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12926 | ELAVL2 | S221 | ochoa | ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1) | RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity). {ECO:0000250|UniProtKB:Q60899}. |
| Q13085 | ACACA | S104 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13207 | TBX2 | S401 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13363 | CTBP1 | S422 | psp | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Q13490 | BIRC2 | S98 | ochoa | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}. |
| Q13950 | RUNX2 | S465 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14106 | TOB2 | S222 | ochoa | Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2) | Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. |
| Q14296 | FASTK | S45 | ochoa | Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8) | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}.; FUNCTION: [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. {ECO:0000269|PubMed:25704814}. |
| Q14451 | GRB7 | S76 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14814 | MEF2D | S192 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14914 | PTGR1 | S88 | ochoa | Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74) | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}. |
| Q15046 | KARS1 | S470 | ochoa | Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}. |
| Q15434 | RBMS2 | S35 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q15796 | SMAD2 | S245 | ochoa|psp | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q15858 | SCN9A | S113 | ochoa | Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) | Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784, PubMed:25240195, PubMed:26680203, PubMed:7720699). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784). {ECO:0000269|PubMed:15178348, ECO:0000269|PubMed:15385606, ECO:0000269|PubMed:16988069, ECO:0000269|PubMed:17145499, ECO:0000269|PubMed:17167479, ECO:0000269|PubMed:19369487, ECO:0000269|PubMed:24311784, ECO:0000269|PubMed:25240195, ECO:0000269|PubMed:26680203, ECO:0000269|PubMed:7720699}. |
| Q15942 | ZYX | S344 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16512 | PKN1 | S603 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q2KJY2 | KIF26B | S1958 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2PPJ7 | RALGAPA2 | S1593 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q2TAL8 | QRICH1 | S736 | ochoa | Transcriptional regulator QRICH1 (Glutamine-rich protein 1) | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. |
| Q3KQV3 | ZNF792 | S121 | ochoa | Zinc finger protein 792 | May be involved in transcriptional regulation. |
| Q3V6T2 | CCDC88A | S1675 | ochoa|psp | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q4AC94 | C2CD3 | S1912 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4KMQ1 | TPRN | S241 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q4KMQ1 | TPRN | S418 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q504Q3 | PAN2 | S791 | ochoa | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}. |
| Q53EL6 | PDCD4 | S94 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q53ET0 | CRTC2 | S433 | ochoa|psp | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q53GL7 | PARP10 | S431 | ochoa | Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}. |
| Q53RE8 | ANKRD39 | S153 | ochoa | Ankyrin repeat domain-containing protein 39 | None |
| Q5PSV4 | BRMS1L | S197 | ochoa | Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) | Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. {ECO:0000269|PubMed:15451426}. |
| Q5T1R4 | HIVEP3 | S2034 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5TCZ1 | SH3PXD2A | S406 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q659C4 | LARP1B | S335 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q684P5 | RAP1GAP2 | S45 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q68CP4 | HGSNAT | S243 | ochoa | Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) | Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}. |
| Q69YH5 | CDCA2 | S309 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6P1M0 | SLC27A4 | S555 | ochoa | Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-) | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213). Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:22022213, PubMed:24269233). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). {ECO:0000250|UniProtKB:Q91VE0, ECO:0000269|PubMed:10518211, ECO:0000269|PubMed:12556534, ECO:0000269|PubMed:20448275, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}. |
| Q6P1R3 | MSANTD2 | S436 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6P2H3 | CEP85 | S663 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6P3S6 | FBXO42 | S393 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6P996 | PDXDC1 | S652 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PGN9 | PSRC1 | S70 | ochoa|psp | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6UB99 | ANKRD11 | S1847 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UUV7 | CRTC3 | S135 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UUV7 | CRTC3 | S413 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZNJ1 | NBEAL2 | S2208 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZW76 | ANKS3 | S416 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
| Q70EL4 | USP43 | S1041 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q711Q0 | CEFIP | S252 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q7Z2W4 | ZC3HAV1 | S275 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z406 | MYH14 | S221 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z434 | MAVS | S222 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z6B7 | SRGAP1 | S999 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86T90 | KIAA1328 | S484 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86UR5 | RIMS1 | S578 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86XA9 | HEATR5A | S1704 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YV0 | RASAL3 | S988 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IUG5 | MYO18B | S2193 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IVJ1 | SLC41A1 | S89 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
| Q8IW93 | ARHGEF19 | S336 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWC1 | MAP7D3 | S770 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWE2 | FAM114A1 | S120 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IWT3 | CUL9 | S947 | ochoa | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}. |
| Q8IX90 | SKA3 | S267 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8N1G1 | REXO1 | S459 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N201 | INTS1 | S104 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N302 | AGGF1 | S176 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3D4 | EHBP1L1 | S964 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N441 | FGFRL1 | S452 | ochoa | Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) | Has a negative effect on cell proliferation. {ECO:0000250}. |
| Q8N5C8 | TAB3 | S80 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N6F7 | GCSAM | S143 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8NC74 | RBBP8NL | S466 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NCE2 | MTMR14 | S624 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NDX1 | PSD4 | S143 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEZ4 | KMT2C | S3758 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFQ8 | TOR1AIP2 | S163 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NFU5 | IPMK | S22 | ochoa | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}. |
| Q8NFW9 | MYRIP | S350 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8NFY4 | SEMA6D | S723 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8TB72 | PUM2 | S182 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TBC4 | UBA3 | S377 | ochoa | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}. |
| Q8TDJ6 | DMXL2 | S588 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEJ3 | SH3RF3 | S804 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
| Q8TEK3 | DOT1L | S458 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEW0 | PARD3 | S1139 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WW38 | ZFPM2 | S904 | ochoa | Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. |
| Q8WXG6 | MADD | S1270 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WZ75 | ROBO4 | S684 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92536 | SLC7A6 | S30 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
| Q92766 | RREB1 | S1225 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q969F9 | HPS3 | S648 | ochoa | BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) | Involved in early stages of melanosome biogenesis and maturation. {ECO:0000250|UniProtKB:Q91VB4}. |
| Q96B01 | RAD51AP1 | S318 | ochoa | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}. |
| Q96B97 | SH3KBP1 | S572 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96DG6 | CMBL | S223 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q96F81 | DISP1 | S51 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96FX7 | TRMT61A | S263 | ochoa | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) | Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}. |
| Q96HB5 | CCDC120 | S256 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96HW7 | INTS4 | S600 | ochoa | Integrator complex subunit 4 (Int4) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS4 acts as an scaffold that links INTS9 and INTS11 (PubMed:29471365, PubMed:33548203). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}. |
| Q96I34 | PPP1R16A | S418 | ochoa | Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) | Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}. |
| Q96M11 | HYLS1 | S179 | ochoa | Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) | Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. |
| Q96MT3 | PRICKLE1 | S353 | ochoa | Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}. |
| Q96PC5 | MIA2 | S1125 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96QS3 | ARX | S67 | ochoa|psp | Homeobox protein ARX (Aristaless-related homeobox) | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}. |
| Q96RU3 | FNBP1 | S517 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q96S38 | RPS6KC1 | S449 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96ST3 | SIN3A | S1112 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99081 | TCF12 | S386 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q9BQA1 | WDR77 | S176 | ochoa | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. |
| Q9BQC3 | DPH2 | S446 | ochoa | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}. |
| Q9BSQ5 | CCM2 | S164 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BSQ5 | CCM2 | S280 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BWT3 | PAPOLG | S23 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXK5 | BCL2L13 | S444 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BYJ9 | YTHDF1 | S350 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9BZ95 | NSD3 | S107 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZC7 | ABCA2 | S2381 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9BZQ8 | NIBAN1 | S596 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9C000 | NLRP1 | S1371 | psp | NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] | Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:27662089, PubMed:31484767, PubMed:33093214, PubMed:33410748, PubMed:33731929, PubMed:33731932, PubMed:35857590). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:12191486, PubMed:17349957, PubMed:22665479). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by some human enteroviruses and rhinoviruses, double-stranded RNA, UV-B irradiation, or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:25562666, PubMed:30096351, PubMed:30291141, PubMed:33093214, PubMed:33243852, PubMed:33410748, PubMed:35857590). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:32051255, PubMed:33093214). In the absence of GSDMD expression, the NLRP1 inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (PubMed:33852854, PubMed:35594856). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses, such as Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). The NLRP1 inflammasome is also activated in response to UV-B irradiation causing ribosome collisions: ribosome collisions cause phosphorylation and activation of NLRP1 in a MAP3K20-dependent manner, leading to pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:11113115, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15212762, ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:22665479, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:25562666, ECO:0000269|PubMed:27662089, ECO:0000269|PubMed:30096351, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31484767, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33243852, ECO:0000269|PubMed:33410748, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856, ECO:0000269|PubMed:35857590}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1]: Constitutes the precursor of the NLRP1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. {ECO:0000269|PubMed:22087307}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, N-terminus]: Regulatory part that prevents formation of the NLRP1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the NLRP1 inflammasome (PubMed:33093214). {ECO:0000269|PubMed:33093214}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Constitutes the active part of the NLRP1 inflammasome (PubMed:33093214, PubMed:33731929, PubMed:33731932). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing this form, which polymerizes and associates with PYCARD/ASC to form of the NLRP1 inflammasome complex: the NLRP1 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:33093214). {ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932}.; FUNCTION: [Isoform 2]: It is unclear whether is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). {ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:22665479}. |
| Q9C004 | SPRY4 | S125 | ochoa | Protein sprouty homolog 4 (Spry-4) | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}. |
| Q9C0A1 | ZFHX2 | S686 | ochoa | Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2) | Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. {ECO:0000269|PubMed:29253101}. |
| Q9C0C2 | TNKS1BP1 | S601 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZT8 | NIF3L1 | Y161 | ochoa | NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein) | May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}. |
| Q9H0W8 | SMG9 | S451 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H1A4 | ANAPC1 | S731 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H4L4 | SENP3 | S307 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H694 | BICC1 | S576 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H6A9 | PCNX3 | S1955 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H707 | ZNF552 | S86 | ochoa | Zinc finger protein 552 | May be involved in transcriptional regulation. |
| Q9H7D0 | DOCK5 | S365 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H7D0 | DOCK5 | S1756 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H8T0 | AKTIP | S30 | ochoa | AKT-interacting protein (Ft1) (Fused toes protein homolog) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9HAF1 | MEAF6 | S125 | ochoa | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}. |
| Q9HAS0 | C17orf75 | S59 | ochoa | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
| Q9HBT8 | ZNF286A | S19 | ochoa | Zinc finger protein 286A | May be involved in transcriptional regulation. |
| Q9HCM4 | EPB41L5 | S436 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NRA8 | EIF4ENIF1 | S301 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRF2 | SH2B1 | S88 | ochoa | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
| Q9NS56 | TOPORS | S98 | ochoa|psp | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NUL7 | DDX28 | S28 | ochoa | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}. |
| Q9NUU7 | DDX19A | S85 | ochoa | ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}. |
| Q9NVP2 | ASF1B | S20 | ochoa | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}. |
| Q9NXL9 | MCM9 | S1088 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NZL9 | MAT2B | S282 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| Q9P202 | WHRN | S685 | ochoa | Whirlin (Autosomal recessive deafness type 31 protein) | Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}. |
| Q9P260 | RELCH | S244 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P2D6 | FAM135A | S953 | ochoa | Protein FAM135A | None |
| Q9P2F8 | SIPA1L2 | S1029 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2K1 | CC2D2A | S1080 | ochoa | Coiled-coil and C2 domain-containing protein 2A | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:18513680}. |
| Q9P2N6 | KANSL3 | S736 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9UBN7 | HDAC6 | S1035 | psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UEG4 | ZNF629 | S745 | ochoa | Zinc finger protein 629 (Zinc finger protein 65) | May be involved in transcriptional regulation. |
| Q9UG63 | ABCF2 | S512 | ochoa | ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2) | None |
| Q9UHB7 | AFF4 | S1043 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIF8 | BAZ2B | S405 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKV0 | HDAC9 | S422 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULM3 | YEATS2 | S868 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UMR2 | DDX19B | S86 | ochoa | ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) | ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}. |
| Q9UNZ2 | NSFL1C | S60 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN3 | MACF1 | S5808 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPY3 | DICER1 | S1280 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9Y242 | TCF19 | S167 | ochoa | Transcription factor 19 (TCF-19) (Transcription factor SC1) | Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition (PubMed:1868030, PubMed:31141247). May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1 (PubMed:31141247). {ECO:0000269|PubMed:1868030, ECO:0000269|PubMed:31141247}. |
| Q9Y2G1 | MYRF | S148 | ochoa | Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal] | [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269|PubMed:23966832}. |
| Q9Y2H5 | PLEKHA6 | S426 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2H9 | MAST1 | S1242 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I7 | PIKFYVE | S1544 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2U5 | MAP3K2 | S344 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y485 | DMXL1 | S1754 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4H2 | IRS2 | S770 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4P8 | WIPI2 | S413 | ochoa|psp | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}. |
| Q9Y6I4 | USP3 | S350 | ochoa | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}. |
| O75925 | PIAS1 | S90 | iPTMNet | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| P50895 | BCAM | S296 | Sugiyama | Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}. |
| Q08J23 | NSUN2 | S383 | Sugiyama | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q01196 | RUNX1 | S397 | SIGNOR | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| P51858 | HDGF | S40 | Sugiyama | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| Q16600 | ZNF239 | S129 | GPS6 | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| P29144 | TPP2 | S25 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| Q8NE63 | HIPK4 | S411 | Sugiyama | Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) | Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.000225 | 3.648 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000129 | 3.889 |
| R-HSA-4641265 | Repression of WNT target genes | 0.000275 | 3.561 |
| R-HSA-2586552 | Signaling by Leptin | 0.000125 | 3.902 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.000189 | 3.724 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.000727 | 3.138 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.001292 | 2.889 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.001265 | 2.898 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.002159 | 2.666 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.002024 | 2.694 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.002738 | 2.562 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.002448 | 2.611 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.002859 | 2.544 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.002554 | 2.593 |
| R-HSA-525793 | Myogenesis | 0.003472 | 2.459 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.003585 | 2.446 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.004755 | 2.323 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.005244 | 2.280 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.005766 | 2.239 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.005766 | 2.239 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.004226 | 2.374 |
| R-HSA-186763 | Downstream signal transduction | 0.005766 | 2.239 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.005134 | 2.290 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.004647 | 2.333 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.005567 | 2.254 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.008078 | 2.093 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.006912 | 2.160 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.006912 | 2.160 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.007538 | 2.123 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.007538 | 2.123 |
| R-HSA-75893 | TNF signaling | 0.008025 | 2.096 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.008200 | 2.086 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.008323 | 2.080 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.008323 | 2.080 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.008898 | 2.051 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.010410 | 1.983 |
| R-HSA-191859 | snRNP Assembly | 0.009644 | 2.016 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.009644 | 2.016 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.010410 | 1.983 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.012078 | 1.918 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.012972 | 1.887 |
| R-HSA-9707616 | Heme signaling | 0.011473 | 1.940 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.012972 | 1.887 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.012972 | 1.887 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.011224 | 1.950 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.012078 | 1.918 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.012931 | 1.888 |
| R-HSA-9645135 | STAT5 Activation | 0.013026 | 1.885 |
| R-HSA-447043 | Neurofascin interactions | 0.013026 | 1.885 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.013026 | 1.885 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.013851 | 1.859 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.013908 | 1.857 |
| R-HSA-3371556 | Cellular response to heat stress | 0.015653 | 1.805 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.016075 | 1.794 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.018444 | 1.734 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.019225 | 1.716 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.020419 | 1.690 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.018982 | 1.722 |
| R-HSA-9675135 | Diseases of DNA repair | 0.020419 | 1.690 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.020419 | 1.690 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.020599 | 1.686 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.022313 | 1.651 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.021920 | 1.659 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.022313 | 1.651 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.022115 | 1.655 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.025728 | 1.590 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.025728 | 1.590 |
| R-HSA-74160 | Gene expression (Transcription) | 0.024371 | 1.613 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.024936 | 1.603 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.023782 | 1.624 |
| R-HSA-9909396 | Circadian clock | 0.024314 | 1.614 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.025866 | 1.587 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.029631 | 1.528 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.027756 | 1.557 |
| R-HSA-157118 | Signaling by NOTCH | 0.028594 | 1.544 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.029631 | 1.528 |
| R-HSA-1632852 | Macroautophagy | 0.032886 | 1.483 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.037294 | 1.428 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 0.037294 | 1.428 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 0.037294 | 1.428 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.036982 | 1.432 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.033599 | 1.474 |
| R-HSA-4839726 | Chromatin organization | 0.034775 | 1.459 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.036575 | 1.437 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.041962 | 1.377 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.041962 | 1.377 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.041962 | 1.377 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.041962 | 1.377 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.041962 | 1.377 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.042110 | 1.376 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.037761 | 1.423 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.037761 | 1.423 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.037761 | 1.423 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.037761 | 1.423 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.039133 | 1.407 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.042110 | 1.376 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.043171 | 1.365 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.043853 | 1.358 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.049682 | 1.304 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.043853 | 1.358 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.044249 | 1.354 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.049806 | 1.303 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.046926 | 1.329 |
| R-HSA-186797 | Signaling by PDGF | 0.045790 | 1.339 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.045790 | 1.339 |
| R-HSA-8853659 | RET signaling | 0.049682 | 1.304 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.046635 | 1.331 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.045802 | 1.339 |
| R-HSA-9612973 | Autophagy | 0.050423 | 1.297 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.051329 | 1.290 |
| R-HSA-196780 | Biotin transport and metabolism | 0.051329 | 1.290 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.051884 | 1.285 |
| R-HSA-212436 | Generic Transcription Pathway | 0.052741 | 1.278 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.055419 | 1.256 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 0.055419 | 1.256 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 0.055419 | 1.256 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 0.055419 | 1.256 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 0.055419 | 1.256 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 0.055419 | 1.256 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.058400 | 1.234 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.061194 | 1.213 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.055419 | 1.256 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.061194 | 1.213 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.062975 | 1.201 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.056185 | 1.250 |
| R-HSA-70171 | Glycolysis | 0.062398 | 1.205 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.064597 | 1.190 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.066349 | 1.178 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.067733 | 1.169 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.067801 | 1.169 |
| R-HSA-2206291 | MPS IIIC - Sanfilippo syndrome C | 0.073202 | 1.135 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.077068 | 1.113 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.082619 | 1.083 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.082619 | 1.083 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.082619 | 1.083 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.082619 | 1.083 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.071643 | 1.145 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.070180 | 1.154 |
| R-HSA-5358508 | Mismatch Repair | 0.071643 | 1.145 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.073202 | 1.135 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.071643 | 1.145 |
| R-HSA-165159 | MTOR signalling | 0.071076 | 1.148 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.077068 | 1.113 |
| R-HSA-211000 | Gene Silencing by RNA | 0.078561 | 1.105 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.077068 | 1.113 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.077068 | 1.113 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.074421 | 1.128 |
| R-HSA-72306 | tRNA processing | 0.071406 | 1.146 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.071643 | 1.145 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.077789 | 1.109 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.090653 | 1.043 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.090653 | 1.043 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.090653 | 1.043 |
| R-HSA-8941237 | Invadopodia formation | 0.090653 | 1.043 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 0.090653 | 1.043 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.107775 | 0.967 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.107775 | 0.967 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.107775 | 0.967 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.107775 | 0.967 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.107775 | 0.967 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.107775 | 0.967 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.107775 | 0.967 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.107775 | 0.967 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.124577 | 0.905 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.124577 | 0.905 |
| R-HSA-74713 | IRS activation | 0.124577 | 0.905 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.124577 | 0.905 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.141063 | 0.851 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.141063 | 0.851 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.141063 | 0.851 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.141063 | 0.851 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.141063 | 0.851 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.157239 | 0.803 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.173112 | 0.762 |
| R-HSA-112412 | SOS-mediated signalling | 0.173112 | 0.762 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.173112 | 0.762 |
| R-HSA-5619108 | Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) | 0.173112 | 0.762 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.188687 | 0.724 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.233678 | 0.631 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.233678 | 0.631 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.118190 | 0.927 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.262282 | 0.581 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.262282 | 0.581 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.262282 | 0.581 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.276183 | 0.559 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.289822 | 0.538 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.303205 | 0.518 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.303205 | 0.518 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.303205 | 0.518 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.316337 | 0.500 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.316337 | 0.500 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.341865 | 0.466 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.366442 | 0.436 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.366442 | 0.436 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.163081 | 0.788 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.378386 | 0.422 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.390105 | 0.409 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.225268 | 0.647 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.423958 | 0.373 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.423958 | 0.373 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.315741 | 0.501 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.265532 | 0.576 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.265532 | 0.576 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.124442 | 0.905 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.094181 | 1.026 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.378386 | 0.422 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.291124 | 0.536 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.173112 | 0.762 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.342252 | 0.466 |
| R-HSA-198203 | PI3K/AKT activation | 0.218964 | 0.660 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.188687 | 0.724 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.276183 | 0.559 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.322675 | 0.491 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.163407 | 0.787 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.343364 | 0.464 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.262282 | 0.581 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.231910 | 0.635 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.162531 | 0.789 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.341865 | 0.466 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.099981 | 1.000 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.176839 | 0.752 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.157239 | 0.803 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.329222 | 0.483 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.170101 | 0.769 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.417176 | 0.380 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.157239 | 0.803 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.191148 | 0.719 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.150174 | 0.823 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.329222 | 0.483 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.366442 | 0.436 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.413003 | 0.384 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.260445 | 0.584 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.112021 | 0.951 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.337520 | 0.472 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.215630 | 0.666 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.090653 | 1.043 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.090653 | 1.043 |
| R-HSA-8964540 | Alanine metabolism | 0.107775 | 0.967 |
| R-HSA-8866376 | Reelin signalling pathway | 0.124577 | 0.905 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.124577 | 0.905 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.141063 | 0.851 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.173112 | 0.762 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.203969 | 0.690 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.218964 | 0.660 |
| R-HSA-429947 | Deadenylation of mRNA | 0.112021 | 0.951 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.262282 | 0.581 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.276183 | 0.559 |
| R-HSA-804914 | Transport of fatty acids | 0.289822 | 0.538 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.303205 | 0.518 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.329222 | 0.483 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.211069 | 0.676 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.332361 | 0.478 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.354270 | 0.451 |
| R-HSA-9646399 | Aggrephagy | 0.224946 | 0.648 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.094068 | 1.027 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.124442 | 0.905 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.183618 | 0.736 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.329222 | 0.483 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.341865 | 0.466 |
| R-HSA-74749 | Signal attenuation | 0.218964 | 0.660 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.143642 | 0.843 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.150174 | 0.823 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.341865 | 0.466 |
| R-HSA-392517 | Rap1 signalling | 0.366442 | 0.436 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.245875 | 0.609 |
| R-HSA-9824272 | Somitogenesis | 0.266872 | 0.574 |
| R-HSA-1181150 | Signaling by NODAL | 0.378386 | 0.422 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.203969 | 0.690 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.099955 | 1.000 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.289822 | 0.538 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.289822 | 0.538 |
| R-HSA-1502540 | Signaling by Activin | 0.303205 | 0.518 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.377370 | 0.423 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.124756 | 0.904 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.099955 | 1.000 |
| R-HSA-69275 | G2/M Transition | 0.350632 | 0.455 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.358097 | 0.446 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.099955 | 1.000 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.303205 | 0.518 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.107775 | 0.967 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.173112 | 0.762 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.088287 | 1.054 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.088287 | 1.054 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.112021 | 0.951 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.248116 | 0.605 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.329222 | 0.483 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.390105 | 0.409 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.235229 | 0.629 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.190756 | 0.720 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.207202 | 0.684 |
| R-HSA-9609690 | HCMV Early Events | 0.227397 | 0.643 |
| R-HSA-3214847 | HATs acetylate histones | 0.347830 | 0.459 |
| R-HSA-8953854 | Metabolism of RNA | 0.201283 | 0.696 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.303205 | 0.518 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.224946 | 0.648 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.224946 | 0.648 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.225268 | 0.647 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.197284 | 0.705 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.157239 | 0.803 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.234424 | 0.630 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.401604 | 0.396 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.250311 | 0.602 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.224946 | 0.648 |
| R-HSA-447038 | NrCAM interactions | 0.124577 | 0.905 |
| R-HSA-389542 | NADPH regeneration | 0.157239 | 0.803 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.173112 | 0.762 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.173112 | 0.762 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.203969 | 0.690 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.218964 | 0.660 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.248116 | 0.605 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.124442 | 0.905 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.262282 | 0.581 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.262282 | 0.581 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.303205 | 0.518 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 0.303205 | 0.518 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.316337 | 0.500 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.183618 | 0.736 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.412887 | 0.384 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.308791 | 0.510 |
| R-HSA-177929 | Signaling by EGFR | 0.343364 | 0.464 |
| R-HSA-379724 | tRNA Aminoacylation | 0.370624 | 0.431 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.094068 | 1.027 |
| R-HSA-162587 | HIV Life Cycle | 0.241384 | 0.617 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.410359 | 0.387 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.140747 | 0.852 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.141063 | 0.851 |
| R-HSA-447041 | CHL1 interactions | 0.173112 | 0.762 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.233678 | 0.631 |
| R-HSA-200425 | Carnitine shuttle | 0.105941 | 0.975 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.289822 | 0.538 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.303205 | 0.518 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.401604 | 0.396 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.363848 | 0.439 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.404080 | 0.394 |
| R-HSA-9609646 | HCMV Infection | 0.407154 | 0.390 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.087034 | 1.060 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.151841 | 0.819 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.243775 | 0.613 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.166854 | 0.778 |
| R-HSA-373760 | L1CAM interactions | 0.235646 | 0.628 |
| R-HSA-73887 | Death Receptor Signaling | 0.112258 | 0.950 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.423958 | 0.373 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.124577 | 0.905 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.203969 | 0.690 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.170101 | 0.769 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.341865 | 0.466 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.341865 | 0.466 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.378386 | 0.422 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.092152 | 1.035 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.191148 | 0.719 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.186386 | 0.730 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.401604 | 0.396 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.099955 | 1.000 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.401604 | 0.396 |
| R-HSA-162582 | Signal Transduction | 0.349542 | 0.457 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.331933 | 0.479 |
| R-HSA-1266738 | Developmental Biology | 0.415439 | 0.381 |
| R-HSA-210990 | PECAM1 interactions | 0.233678 | 0.631 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.170101 | 0.769 |
| R-HSA-201556 | Signaling by ALK | 0.217998 | 0.662 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.378386 | 0.422 |
| R-HSA-9663891 | Selective autophagy | 0.280860 | 0.552 |
| R-HSA-156590 | Glutathione conjugation | 0.370624 | 0.431 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.423687 | 0.373 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.333370 | 0.477 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.354270 | 0.451 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.423958 | 0.373 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.315741 | 0.501 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.167670 | 0.776 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.245875 | 0.609 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.205614 | 0.687 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.390105 | 0.409 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.390105 | 0.409 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.138829 | 0.858 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.354270 | 0.451 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.195941 | 0.708 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.343364 | 0.464 |
| R-HSA-168255 | Influenza Infection | 0.324593 | 0.489 |
| R-HSA-3214842 | HDMs demethylate histones | 0.118190 | 0.927 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.238887 | 0.622 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.320686 | 0.494 |
| R-HSA-166520 | Signaling by NTRKs | 0.210547 | 0.677 |
| R-HSA-1483255 | PI Metabolism | 0.363263 | 0.440 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.124442 | 0.905 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.262282 | 0.581 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.276183 | 0.559 |
| R-HSA-416700 | Other semaphorin interactions | 0.303205 | 0.518 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.329222 | 0.483 |
| R-HSA-2142700 | Biosynthesis of Lipoxins (LX) | 0.354270 | 0.451 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.390105 | 0.409 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.384087 | 0.416 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.409135 | 0.388 |
| R-HSA-446728 | Cell junction organization | 0.339202 | 0.470 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.343364 | 0.464 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.409135 | 0.388 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.383748 | 0.416 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.197284 | 0.705 |
| R-HSA-210991 | Basigin interactions | 0.390105 | 0.409 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.302453 | 0.519 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.204164 | 0.690 |
| R-HSA-421270 | Cell-cell junction organization | 0.410511 | 0.387 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.268516 | 0.571 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.354270 | 0.451 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.384087 | 0.416 |
| R-HSA-5688426 | Deubiquitination | 0.270490 | 0.568 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.217998 | 0.662 |
| R-HSA-422475 | Axon guidance | 0.282463 | 0.549 |
| R-HSA-9675108 | Nervous system development | 0.361182 | 0.442 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.132124 | 0.879 |
| R-HSA-70326 | Glucose metabolism | 0.106583 | 0.972 |
| R-HSA-1538133 | G0 and Early G1 | 0.163407 | 0.787 |
| R-HSA-2262752 | Cellular responses to stress | 0.188644 | 0.724 |
| R-HSA-210993 | Tie2 Signaling | 0.354270 | 0.451 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.154021 | 0.812 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.412887 | 0.384 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.169806 | 0.770 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.112258 | 0.950 |
| R-HSA-9607240 | FLT3 Signaling | 0.231910 | 0.635 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.211069 | 0.676 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.105633 | 0.976 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.294693 | 0.531 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.370624 | 0.431 |
| R-HSA-9945266 | Differentiation of T cells | 0.316337 | 0.500 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.316337 | 0.500 |
| R-HSA-68875 | Mitotic Prophase | 0.251967 | 0.599 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.230238 | 0.638 |
| R-HSA-163685 | Integration of energy metabolism | 0.331933 | 0.479 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.105941 | 0.975 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.403086 | 0.395 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.185468 | 0.732 |
| R-HSA-373755 | Semaphorin interactions | 0.390772 | 0.408 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.170101 | 0.769 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.259870 | 0.585 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.170101 | 0.769 |
| R-HSA-5218859 | Regulated Necrosis | 0.423687 | 0.373 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.091343 | 1.039 |
| R-HSA-5619102 | SLC transporter disorders | 0.276950 | 0.558 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.239703 | 0.620 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.112062 | 0.951 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.425672 | 0.371 |
| R-HSA-9610379 | HCMV Late Events | 0.425672 | 0.371 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.429584 | 0.367 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.434820 | 0.362 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.434820 | 0.362 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.434820 | 0.362 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.434820 | 0.362 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.434820 | 0.362 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.434820 | 0.362 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.436596 | 0.360 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.436596 | 0.360 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.438273 | 0.358 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.439510 | 0.357 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.445479 | 0.351 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.445479 | 0.351 |
| R-HSA-420029 | Tight junction interactions | 0.445479 | 0.351 |
| R-HSA-9839394 | TGFBR3 expression | 0.445479 | 0.351 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.445479 | 0.351 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.445479 | 0.351 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.449348 | 0.347 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.453966 | 0.343 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.454948 | 0.342 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.454948 | 0.342 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.455662 | 0.341 |
| R-HSA-1500931 | Cell-Cell communication | 0.455917 | 0.341 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.455937 | 0.341 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.455937 | 0.341 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.455937 | 0.341 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.455937 | 0.341 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.461935 | 0.335 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.461935 | 0.335 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.466199 | 0.331 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.466199 | 0.331 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.466199 | 0.331 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.466199 | 0.331 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.466199 | 0.331 |
| R-HSA-264876 | Insulin processing | 0.466199 | 0.331 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.466199 | 0.331 |
| R-HSA-418990 | Adherens junctions interactions | 0.472923 | 0.325 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.473442 | 0.325 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.476267 | 0.322 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.476267 | 0.322 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.476267 | 0.322 |
| R-HSA-622312 | Inflammasomes | 0.476267 | 0.322 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.476267 | 0.322 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.477172 | 0.321 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.480497 | 0.318 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.480497 | 0.318 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.486147 | 0.313 |
| R-HSA-72086 | mRNA Capping | 0.486147 | 0.313 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.486147 | 0.313 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.486147 | 0.313 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.486147 | 0.313 |
| R-HSA-9659379 | Sensory processing of sound | 0.492651 | 0.307 |
| R-HSA-2424491 | DAP12 signaling | 0.495840 | 0.305 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.495840 | 0.305 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.495840 | 0.305 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.495840 | 0.305 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.495840 | 0.305 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.495840 | 0.305 |
| R-HSA-2206281 | Mucopolysaccharidoses | 0.495840 | 0.305 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.495868 | 0.305 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.495868 | 0.305 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.498661 | 0.302 |
| R-HSA-162906 | HIV Infection | 0.505211 | 0.297 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.505351 | 0.296 |
| R-HSA-182971 | EGFR downregulation | 0.505351 | 0.296 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.505351 | 0.296 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.505351 | 0.296 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.514684 | 0.288 |
| R-HSA-2024096 | HS-GAG degradation | 0.514684 | 0.288 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.514684 | 0.288 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.514684 | 0.288 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.515803 | 0.288 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.516415 | 0.287 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.522240 | 0.282 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.523841 | 0.281 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.523841 | 0.281 |
| R-HSA-9930044 | Nuclear RNA decay | 0.523841 | 0.281 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.532826 | 0.273 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.533749 | 0.273 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.535442 | 0.271 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.539432 | 0.268 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.539432 | 0.268 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.541641 | 0.266 |
| R-HSA-5205647 | Mitophagy | 0.541641 | 0.266 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.550291 | 0.259 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.550291 | 0.259 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.550291 | 0.259 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.550291 | 0.259 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.550291 | 0.259 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.550291 | 0.259 |
| R-HSA-3371511 | HSF1 activation | 0.558778 | 0.253 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.561682 | 0.251 |
| R-HSA-5617833 | Cilium Assembly | 0.562203 | 0.250 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.567106 | 0.246 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.567106 | 0.246 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.567106 | 0.246 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.567106 | 0.246 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.567106 | 0.246 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.572516 | 0.242 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.573897 | 0.241 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.575277 | 0.240 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.577860 | 0.238 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.583294 | 0.234 |
| R-HSA-71336 | Pentose phosphate pathway | 0.583294 | 0.234 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.584462 | 0.233 |
| R-HSA-73894 | DNA Repair | 0.584777 | 0.233 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.591160 | 0.228 |
| R-HSA-202433 | Generation of second messenger molecules | 0.591160 | 0.228 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.591160 | 0.228 |
| R-HSA-167169 | HIV Transcription Elongation | 0.591160 | 0.228 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.591160 | 0.228 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.591160 | 0.228 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.598878 | 0.223 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.598878 | 0.223 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.598878 | 0.223 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.598878 | 0.223 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.598878 | 0.223 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.603615 | 0.219 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.603845 | 0.219 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.603845 | 0.219 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.606451 | 0.217 |
| R-HSA-167161 | HIV Transcription Initiation | 0.606451 | 0.217 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.606451 | 0.217 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.606451 | 0.217 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.606451 | 0.217 |
| R-HSA-189451 | Heme biosynthesis | 0.606451 | 0.217 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.606451 | 0.217 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.611777 | 0.213 |
| R-HSA-69242 | S Phase | 0.611777 | 0.213 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.613882 | 0.212 |
| R-HSA-190236 | Signaling by FGFR | 0.613896 | 0.212 |
| R-HSA-9758941 | Gastrulation | 0.615816 | 0.211 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.618848 | 0.208 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.621172 | 0.207 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.621172 | 0.207 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.621172 | 0.207 |
| R-HSA-8854214 | TBC/RABGAPs | 0.621172 | 0.207 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.628326 | 0.202 |
| R-HSA-2172127 | DAP12 interactions | 0.628326 | 0.202 |
| R-HSA-9907900 | Proteasome assembly | 0.628326 | 0.202 |
| R-HSA-156581 | Methylation | 0.628326 | 0.202 |
| R-HSA-373752 | Netrin-1 signaling | 0.628326 | 0.202 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.628326 | 0.202 |
| R-HSA-69236 | G1 Phase | 0.628326 | 0.202 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.628326 | 0.202 |
| R-HSA-1640170 | Cell Cycle | 0.631250 | 0.200 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.635345 | 0.197 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.635345 | 0.197 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.635345 | 0.197 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.635345 | 0.197 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.635345 | 0.197 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.635345 | 0.197 |
| R-HSA-1989781 | PPARA activates gene expression | 0.639453 | 0.194 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.642231 | 0.192 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.642231 | 0.192 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.642231 | 0.192 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.642231 | 0.192 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.642231 | 0.192 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.642231 | 0.192 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.642231 | 0.192 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.642231 | 0.192 |
| R-HSA-75153 | Apoptotic execution phase | 0.642231 | 0.192 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.642877 | 0.192 |
| R-HSA-68886 | M Phase | 0.645894 | 0.190 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.647538 | 0.189 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.647538 | 0.189 |
| R-HSA-9833110 | RSV-host interactions | 0.647538 | 0.189 |
| R-HSA-913531 | Interferon Signaling | 0.648430 | 0.188 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.648988 | 0.188 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.648988 | 0.188 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.652150 | 0.186 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.655618 | 0.183 |
| R-HSA-425410 | Metal ion SLC transporters | 0.655618 | 0.183 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.656714 | 0.183 |
| R-HSA-68882 | Mitotic Anaphase | 0.656963 | 0.182 |
| R-HSA-9679506 | SARS-CoV Infections | 0.657444 | 0.182 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.658360 | 0.182 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.660196 | 0.180 |
| R-HSA-73893 | DNA Damage Bypass | 0.662123 | 0.179 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.665699 | 0.177 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.668506 | 0.175 |
| R-HSA-109704 | PI3K Cascade | 0.668506 | 0.175 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.668506 | 0.175 |
| R-HSA-8951664 | Neddylation | 0.672919 | 0.172 |
| R-HSA-912446 | Meiotic recombination | 0.674768 | 0.171 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.680912 | 0.167 |
| R-HSA-72187 | mRNA 3'-end processing | 0.680912 | 0.167 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.680912 | 0.167 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.680912 | 0.167 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.683100 | 0.166 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.683100 | 0.166 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.686392 | 0.163 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.686941 | 0.163 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.686941 | 0.163 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.686941 | 0.163 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.686941 | 0.163 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.691409 | 0.160 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.691520 | 0.160 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.691520 | 0.160 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.692856 | 0.159 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.697415 | 0.157 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.698660 | 0.156 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.698660 | 0.156 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.698660 | 0.156 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.698660 | 0.156 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.699755 | 0.155 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.703804 | 0.153 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.704354 | 0.152 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.704354 | 0.152 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.704354 | 0.152 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.706734 | 0.151 |
| R-HSA-112399 | IRS-mediated signalling | 0.709942 | 0.149 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.709942 | 0.149 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.709942 | 0.149 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.714018 | 0.146 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.715424 | 0.145 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.715424 | 0.145 |
| R-HSA-5693538 | Homology Directed Repair | 0.715679 | 0.145 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.715682 | 0.145 |
| R-HSA-8939211 | ESR-mediated signaling | 0.720491 | 0.142 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.720802 | 0.142 |
| R-HSA-186712 | Regulation of beta-cell development | 0.720802 | 0.142 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.720802 | 0.142 |
| R-HSA-195721 | Signaling by WNT | 0.723326 | 0.141 |
| R-HSA-983189 | Kinesins | 0.726080 | 0.139 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.726080 | 0.139 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.726080 | 0.139 |
| R-HSA-199991 | Membrane Trafficking | 0.728117 | 0.138 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.731257 | 0.136 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.731257 | 0.136 |
| R-HSA-450294 | MAP kinase activation | 0.731257 | 0.136 |
| R-HSA-211976 | Endogenous sterols | 0.731257 | 0.136 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.734583 | 0.134 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.736338 | 0.133 |
| R-HSA-1268020 | Mitochondrial protein import | 0.736338 | 0.133 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.736605 | 0.133 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.738847 | 0.131 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.741322 | 0.130 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.741322 | 0.130 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.741322 | 0.130 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.745406 | 0.128 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.745406 | 0.128 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.745406 | 0.128 |
| R-HSA-194138 | Signaling by VEGF | 0.745406 | 0.128 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.746213 | 0.127 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.746213 | 0.127 |
| R-HSA-211981 | Xenobiotics | 0.746213 | 0.127 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.751012 | 0.124 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.753890 | 0.123 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.755720 | 0.122 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.755720 | 0.122 |
| R-HSA-196807 | Nicotinate metabolism | 0.760339 | 0.119 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.760339 | 0.119 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.762432 | 0.118 |
| R-HSA-167172 | Transcription of the HIV genome | 0.764871 | 0.116 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.764871 | 0.116 |
| R-HSA-68877 | Mitotic Prometaphase | 0.767992 | 0.115 |
| R-HSA-9843745 | Adipogenesis | 0.769199 | 0.114 |
| R-HSA-9717189 | Sensory perception of taste | 0.769199 | 0.114 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.772436 | 0.112 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.773681 | 0.111 |
| R-HSA-448424 | Interleukin-17 signaling | 0.773681 | 0.111 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.773681 | 0.111 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.774922 | 0.111 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.777962 | 0.109 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.777962 | 0.109 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.777962 | 0.109 |
| R-HSA-189445 | Metabolism of porphyrins | 0.777962 | 0.109 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.777962 | 0.109 |
| R-HSA-8978934 | Metabolism of cofactors | 0.777962 | 0.109 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.786283 | 0.104 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.786283 | 0.104 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.786283 | 0.104 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.786283 | 0.104 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.790326 | 0.102 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.790326 | 0.102 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.791037 | 0.102 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.794223 | 0.100 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.794293 | 0.100 |
| R-HSA-380287 | Centrosome maturation | 0.794293 | 0.100 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.794293 | 0.100 |
| R-HSA-917937 | Iron uptake and transport | 0.794293 | 0.100 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.796934 | 0.099 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.798185 | 0.098 |
| R-HSA-5689603 | UCH proteinases | 0.798185 | 0.098 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.801402 | 0.096 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.805750 | 0.094 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.805750 | 0.094 |
| R-HSA-4086400 | PCP/CE pathway | 0.805750 | 0.094 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.805750 | 0.094 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.809426 | 0.092 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.809426 | 0.092 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.811037 | 0.091 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.813033 | 0.090 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.813033 | 0.090 |
| R-HSA-9833482 | PKR-mediated signaling | 0.813033 | 0.090 |
| R-HSA-6806834 | Signaling by MET | 0.813033 | 0.090 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.820043 | 0.086 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.826544 | 0.083 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.826791 | 0.083 |
| R-HSA-1500620 | Meiosis | 0.830070 | 0.081 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.830070 | 0.081 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.836444 | 0.078 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.836444 | 0.078 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.836651 | 0.077 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.839541 | 0.076 |
| R-HSA-70268 | Pyruvate metabolism | 0.839541 | 0.076 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.842579 | 0.074 |
| R-HSA-156902 | Peptide chain elongation | 0.842579 | 0.074 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.842579 | 0.074 |
| R-HSA-597592 | Post-translational protein modification | 0.845215 | 0.073 |
| R-HSA-9711097 | Cellular response to starvation | 0.848248 | 0.071 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.851355 | 0.070 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.854170 | 0.068 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.856932 | 0.067 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.856932 | 0.067 |
| R-HSA-391251 | Protein folding | 0.856932 | 0.067 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.856932 | 0.067 |
| R-HSA-72312 | rRNA processing | 0.858475 | 0.066 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.859642 | 0.066 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.859642 | 0.066 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.862301 | 0.064 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.864910 | 0.063 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.864910 | 0.063 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.867289 | 0.062 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.867469 | 0.062 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.867469 | 0.062 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.867469 | 0.062 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.869981 | 0.060 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.870677 | 0.060 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.874861 | 0.058 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.874861 | 0.058 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.874861 | 0.058 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.876848 | 0.057 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.877233 | 0.057 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.879560 | 0.056 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.881842 | 0.055 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.881842 | 0.055 |
| R-HSA-192823 | Viral mRNA Translation | 0.886279 | 0.052 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.888435 | 0.051 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.888435 | 0.051 |
| R-HSA-6798695 | Neutrophil degranulation | 0.892844 | 0.049 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.896658 | 0.047 |
| R-HSA-69239 | Synthesis of DNA | 0.896658 | 0.047 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.898618 | 0.046 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.898618 | 0.046 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.898618 | 0.046 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.900094 | 0.046 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.900541 | 0.045 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.900541 | 0.045 |
| R-HSA-202403 | TCR signaling | 0.902427 | 0.045 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.906093 | 0.043 |
| R-HSA-983712 | Ion channel transport | 0.906333 | 0.043 |
| R-HSA-1643685 | Disease | 0.906638 | 0.043 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.907874 | 0.042 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.913019 | 0.040 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.913272 | 0.039 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.914669 | 0.039 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.914669 | 0.039 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.916288 | 0.038 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.916288 | 0.038 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.917876 | 0.037 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.919373 | 0.037 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.920963 | 0.036 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.920964 | 0.036 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.920964 | 0.036 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.924565 | 0.034 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.924752 | 0.034 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.925379 | 0.034 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.925379 | 0.034 |
| R-HSA-449147 | Signaling by Interleukins | 0.926001 | 0.033 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.926796 | 0.033 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.926796 | 0.033 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.926796 | 0.033 |
| R-HSA-72172 | mRNA Splicing | 0.926879 | 0.033 |
| R-HSA-5357801 | Programmed Cell Death | 0.928011 | 0.032 |
| R-HSA-5668914 | Diseases of metabolism | 0.928984 | 0.032 |
| R-HSA-69206 | G1/S Transition | 0.930887 | 0.031 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.932199 | 0.030 |
| R-HSA-114608 | Platelet degranulation | 0.933486 | 0.030 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.933868 | 0.030 |
| R-HSA-397014 | Muscle contraction | 0.935484 | 0.029 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.937204 | 0.028 |
| R-HSA-1474165 | Reproduction | 0.938397 | 0.028 |
| R-HSA-1483257 | Phospholipid metabolism | 0.939153 | 0.027 |
| R-HSA-5576891 | Cardiac conduction | 0.939567 | 0.027 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.939995 | 0.027 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.941841 | 0.026 |
| R-HSA-109582 | Hemostasis | 0.943752 | 0.025 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.946137 | 0.024 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.948165 | 0.023 |
| R-HSA-6807070 | PTEN Regulation | 0.949150 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.949434 | 0.023 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.953802 | 0.021 |
| R-HSA-9824446 | Viral Infection Pathways | 0.954425 | 0.020 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.954681 | 0.020 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.959612 | 0.018 |
| R-HSA-8957322 | Metabolism of steroids | 0.959618 | 0.018 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.961134 | 0.017 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.961134 | 0.017 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.961134 | 0.017 |
| R-HSA-2142753 | Arachidonate metabolism | 0.961134 | 0.017 |
| R-HSA-9609507 | Protein localization | 0.961873 | 0.017 |
| R-HSA-69306 | DNA Replication | 0.961873 | 0.017 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.965365 | 0.015 |
| R-HSA-877300 | Interferon gamma signaling | 0.966024 | 0.015 |
| R-HSA-109581 | Apoptosis | 0.967927 | 0.014 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.968061 | 0.014 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.970866 | 0.013 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.971061 | 0.013 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.974040 | 0.011 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.974535 | 0.011 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.974535 | 0.011 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.975020 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.977705 | 0.010 |
| R-HSA-2559583 | Cellular Senescence | 0.977743 | 0.010 |
| R-HSA-211859 | Biological oxidations | 0.978156 | 0.010 |
| R-HSA-3781865 | Diseases of glycosylation | 0.979392 | 0.009 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.980170 | 0.009 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.982670 | 0.008 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.984856 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 0.988388 | 0.005 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.989458 | 0.005 |
| R-HSA-72766 | Translation | 0.991722 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992222 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.992727 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.993012 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.993881 | 0.003 |
| R-HSA-112316 | Neuronal System | 0.995504 | 0.002 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.995597 | 0.002 |
| R-HSA-416476 | G alpha (q) signalling events | 0.995682 | 0.002 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.996441 | 0.002 |
| R-HSA-1280218 | Adaptive Immune System | 0.996627 | 0.001 |
| R-HSA-9658195 | Leishmania infection | 0.996893 | 0.001 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.996893 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.996968 | 0.001 |
| R-HSA-168256 | Immune System | 0.997221 | 0.001 |
| R-HSA-1474244 | Extracellular matrix organization | 0.998822 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.999633 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.999661 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999723 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 0.999737 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999915 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999993 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999994 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.870 | 0.861 | 1 | 0.818 |
CDK18 |
0.869 | 0.870 | 1 | 0.834 |
P38G |
0.869 | 0.905 | 1 | 0.875 |
CDK17 |
0.867 | 0.881 | 1 | 0.866 |
JNK2 |
0.866 | 0.909 | 1 | 0.833 |
CDK8 |
0.866 | 0.865 | 1 | 0.782 |
CDK3 |
0.865 | 0.781 | 1 | 0.857 |
HIPK2 |
0.862 | 0.787 | 1 | 0.819 |
CDK16 |
0.862 | 0.855 | 1 | 0.851 |
KIS |
0.861 | 0.757 | 1 | 0.760 |
CDK1 |
0.861 | 0.850 | 1 | 0.812 |
ERK1 |
0.861 | 0.870 | 1 | 0.818 |
P38D |
0.860 | 0.880 | 1 | 0.870 |
P38B |
0.859 | 0.877 | 1 | 0.801 |
CDK5 |
0.858 | 0.839 | 1 | 0.755 |
CDK7 |
0.858 | 0.840 | 1 | 0.785 |
JNK3 |
0.857 | 0.895 | 1 | 0.805 |
CDK13 |
0.856 | 0.854 | 1 | 0.808 |
CDK12 |
0.854 | 0.855 | 1 | 0.831 |
DYRK2 |
0.849 | 0.771 | 1 | 0.729 |
P38A |
0.848 | 0.854 | 1 | 0.730 |
CDK10 |
0.847 | 0.793 | 1 | 0.810 |
CDK14 |
0.846 | 0.831 | 1 | 0.793 |
CDK9 |
0.845 | 0.830 | 1 | 0.802 |
DYRK4 |
0.845 | 0.777 | 1 | 0.828 |
ERK2 |
0.843 | 0.853 | 1 | 0.768 |
HIPK1 |
0.840 | 0.710 | 1 | 0.710 |
CDK6 |
0.839 | 0.820 | 1 | 0.813 |
DYRK1B |
0.838 | 0.744 | 1 | 0.783 |
CDK4 |
0.838 | 0.838 | 1 | 0.838 |
JNK1 |
0.837 | 0.803 | 1 | 0.832 |
NLK |
0.837 | 0.775 | 1 | 0.513 |
HIPK4 |
0.836 | 0.504 | 1 | 0.509 |
CLK3 |
0.835 | 0.501 | 1 | 0.472 |
DYRK1A |
0.833 | 0.641 | 1 | 0.690 |
HIPK3 |
0.832 | 0.697 | 1 | 0.684 |
CDK2 |
0.829 | 0.655 | 1 | 0.685 |
SRPK1 |
0.827 | 0.366 | -3 | 0.717 |
ERK5 |
0.824 | 0.430 | 1 | 0.428 |
MAK |
0.819 | 0.554 | -2 | 0.822 |
DYRK3 |
0.818 | 0.555 | 1 | 0.673 |
SRPK2 |
0.816 | 0.295 | -3 | 0.638 |
MTOR |
0.816 | 0.261 | 1 | 0.310 |
ICK |
0.816 | 0.411 | -3 | 0.804 |
CLK1 |
0.812 | 0.409 | -3 | 0.704 |
CDKL5 |
0.812 | 0.209 | -3 | 0.765 |
CLK2 |
0.812 | 0.412 | -3 | 0.702 |
PRP4 |
0.808 | 0.510 | -3 | 0.802 |
MOK |
0.808 | 0.507 | 1 | 0.597 |
CDKL1 |
0.807 | 0.176 | -3 | 0.766 |
CLK4 |
0.806 | 0.363 | -3 | 0.718 |
COT |
0.806 | -0.069 | 2 | 0.843 |
SRPK3 |
0.805 | 0.271 | -3 | 0.679 |
MOS |
0.798 | -0.010 | 1 | 0.171 |
CDC7 |
0.797 | -0.096 | 1 | 0.129 |
PRPK |
0.796 | -0.072 | -1 | 0.840 |
TBK1 |
0.796 | -0.138 | 1 | 0.103 |
ERK7 |
0.794 | 0.274 | 2 | 0.503 |
ATR |
0.792 | -0.042 | 1 | 0.169 |
IKKE |
0.791 | -0.159 | 1 | 0.102 |
GCN2 |
0.791 | -0.185 | 2 | 0.779 |
MST4 |
0.791 | -0.026 | 2 | 0.830 |
NDR2 |
0.790 | -0.033 | -3 | 0.785 |
ULK2 |
0.789 | -0.175 | 2 | 0.773 |
PDHK4 |
0.788 | -0.162 | 1 | 0.185 |
WNK1 |
0.788 | -0.074 | -2 | 0.846 |
NEK6 |
0.788 | -0.071 | -2 | 0.807 |
PRKD1 |
0.788 | -0.021 | -3 | 0.812 |
PIM3 |
0.788 | -0.054 | -3 | 0.785 |
BMPR2 |
0.788 | -0.152 | -2 | 0.845 |
CHAK2 |
0.787 | -0.046 | -1 | 0.810 |
CAMK1B |
0.787 | -0.052 | -3 | 0.818 |
RAF1 |
0.787 | -0.201 | 1 | 0.118 |
NUAK2 |
0.787 | 0.002 | -3 | 0.787 |
PKN3 |
0.787 | -0.055 | -3 | 0.789 |
DSTYK |
0.786 | -0.148 | 2 | 0.850 |
PDHK1 |
0.784 | -0.174 | 1 | 0.163 |
TGFBR2 |
0.784 | -0.093 | -2 | 0.753 |
NDR1 |
0.784 | -0.065 | -3 | 0.788 |
NIK |
0.783 | -0.076 | -3 | 0.837 |
IRE1 |
0.783 | -0.059 | 1 | 0.120 |
PKCD |
0.783 | -0.031 | 2 | 0.764 |
RIPK3 |
0.783 | -0.133 | 3 | 0.813 |
IKKB |
0.783 | -0.195 | -2 | 0.696 |
PKN2 |
0.782 | -0.068 | -3 | 0.794 |
MLK1 |
0.782 | -0.130 | 2 | 0.791 |
RSK2 |
0.782 | -0.027 | -3 | 0.735 |
SKMLCK |
0.781 | -0.074 | -2 | 0.817 |
CAMK2G |
0.781 | -0.109 | 2 | 0.788 |
MPSK1 |
0.781 | 0.101 | 1 | 0.189 |
MARK4 |
0.781 | -0.066 | 4 | 0.847 |
NEK7 |
0.781 | -0.170 | -3 | 0.815 |
P90RSK |
0.781 | -0.024 | -3 | 0.745 |
CAMLCK |
0.780 | -0.042 | -2 | 0.796 |
PRKD2 |
0.780 | -0.027 | -3 | 0.743 |
MLK3 |
0.780 | -0.035 | 2 | 0.718 |
MLK2 |
0.779 | -0.096 | 2 | 0.804 |
IRE2 |
0.779 | -0.042 | 2 | 0.735 |
AMPKA1 |
0.779 | -0.078 | -3 | 0.808 |
ULK1 |
0.778 | -0.172 | -3 | 0.809 |
RSK3 |
0.778 | -0.043 | -3 | 0.736 |
PIM1 |
0.777 | -0.005 | -3 | 0.728 |
DAPK2 |
0.777 | -0.069 | -3 | 0.828 |
MAPKAPK3 |
0.777 | -0.070 | -3 | 0.754 |
LATS2 |
0.777 | -0.059 | -5 | 0.764 |
HUNK |
0.777 | -0.158 | 2 | 0.795 |
WNK3 |
0.777 | -0.192 | 1 | 0.119 |
NIM1 |
0.777 | -0.075 | 3 | 0.827 |
NEK9 |
0.775 | -0.168 | 2 | 0.818 |
BCKDK |
0.775 | -0.160 | -1 | 0.792 |
DNAPK |
0.775 | -0.037 | 1 | 0.163 |
AMPKA2 |
0.775 | -0.059 | -3 | 0.775 |
GRK1 |
0.775 | -0.057 | -2 | 0.764 |
BMPR1B |
0.774 | -0.057 | 1 | 0.102 |
TSSK1 |
0.774 | -0.060 | -3 | 0.830 |
AURC |
0.774 | -0.022 | -2 | 0.602 |
MAPKAPK2 |
0.774 | -0.042 | -3 | 0.700 |
PKCB |
0.774 | -0.033 | 2 | 0.712 |
MASTL |
0.774 | -0.179 | -2 | 0.775 |
VRK2 |
0.773 | 0.069 | 1 | 0.222 |
PINK1 |
0.773 | 0.171 | 1 | 0.332 |
IKKA |
0.773 | -0.122 | -2 | 0.696 |
PKCA |
0.773 | -0.025 | 2 | 0.702 |
PHKG1 |
0.773 | -0.074 | -3 | 0.780 |
CAMK2D |
0.772 | -0.112 | -3 | 0.813 |
GRK5 |
0.772 | -0.187 | -3 | 0.796 |
PKCG |
0.772 | -0.043 | 2 | 0.709 |
ATM |
0.772 | -0.089 | 1 | 0.137 |
P70S6KB |
0.772 | -0.049 | -3 | 0.754 |
PKACG |
0.771 | -0.070 | -2 | 0.670 |
SMG1 |
0.771 | -0.059 | 1 | 0.155 |
TSSK2 |
0.771 | -0.097 | -5 | 0.823 |
TGFBR1 |
0.770 | -0.072 | -2 | 0.761 |
LATS1 |
0.770 | -0.020 | -3 | 0.808 |
PKR |
0.770 | -0.088 | 1 | 0.136 |
GRK7 |
0.770 | -0.021 | 1 | 0.151 |
PRKD3 |
0.770 | -0.035 | -3 | 0.713 |
GSK3A |
0.770 | 0.194 | 4 | 0.414 |
ALK4 |
0.769 | -0.086 | -2 | 0.784 |
DLK |
0.769 | -0.216 | 1 | 0.133 |
RIPK1 |
0.769 | -0.209 | 1 | 0.114 |
MNK2 |
0.769 | -0.067 | -2 | 0.730 |
NUAK1 |
0.769 | -0.061 | -3 | 0.744 |
PAK3 |
0.769 | -0.098 | -2 | 0.729 |
PAK1 |
0.769 | -0.077 | -2 | 0.738 |
CHAK1 |
0.768 | -0.117 | 2 | 0.770 |
ANKRD3 |
0.768 | -0.201 | 1 | 0.135 |
PKCZ |
0.768 | -0.065 | 2 | 0.756 |
MELK |
0.767 | -0.097 | -3 | 0.770 |
TTBK2 |
0.767 | -0.192 | 2 | 0.694 |
YSK4 |
0.767 | -0.161 | 1 | 0.108 |
PAK6 |
0.767 | -0.037 | -2 | 0.648 |
AKT2 |
0.766 | 0.003 | -3 | 0.645 |
MLK4 |
0.766 | -0.100 | 2 | 0.699 |
QSK |
0.766 | -0.055 | 4 | 0.830 |
PKCH |
0.766 | -0.070 | 2 | 0.699 |
QIK |
0.765 | -0.112 | -3 | 0.789 |
MNK1 |
0.765 | -0.053 | -2 | 0.736 |
NEK2 |
0.765 | -0.145 | 2 | 0.796 |
SGK3 |
0.765 | -0.036 | -3 | 0.726 |
FAM20C |
0.764 | -0.037 | 2 | 0.579 |
GRK6 |
0.763 | -0.178 | 1 | 0.115 |
RSK4 |
0.763 | -0.031 | -3 | 0.690 |
PKG2 |
0.762 | -0.047 | -2 | 0.610 |
MEK1 |
0.762 | -0.156 | 2 | 0.834 |
PKACB |
0.762 | -0.026 | -2 | 0.606 |
SIK |
0.762 | -0.067 | -3 | 0.713 |
MSK2 |
0.762 | -0.078 | -3 | 0.707 |
MST3 |
0.762 | -0.044 | 2 | 0.814 |
PIM2 |
0.762 | -0.004 | -3 | 0.707 |
PLK1 |
0.761 | -0.162 | -2 | 0.748 |
BRSK2 |
0.761 | -0.105 | -3 | 0.779 |
PLK4 |
0.761 | -0.132 | 2 | 0.627 |
ACVR2B |
0.761 | -0.109 | -2 | 0.758 |
AURB |
0.761 | -0.052 | -2 | 0.592 |
IRAK4 |
0.761 | -0.112 | 1 | 0.102 |
CAMK4 |
0.761 | -0.160 | -3 | 0.765 |
ACVR2A |
0.760 | -0.113 | -2 | 0.753 |
MARK3 |
0.760 | -0.059 | 4 | 0.791 |
GRK4 |
0.760 | -0.201 | -2 | 0.785 |
CAMK2A |
0.759 | -0.056 | 2 | 0.766 |
BRSK1 |
0.759 | -0.087 | -3 | 0.751 |
CAMK2B |
0.759 | -0.089 | 2 | 0.748 |
TLK2 |
0.759 | -0.151 | 1 | 0.107 |
MEKK1 |
0.759 | -0.142 | 1 | 0.130 |
WNK4 |
0.759 | -0.120 | -2 | 0.834 |
ZAK |
0.758 | -0.150 | 1 | 0.119 |
DCAMKL1 |
0.758 | -0.068 | -3 | 0.742 |
MEK5 |
0.758 | -0.145 | 2 | 0.812 |
PKCT |
0.758 | -0.065 | 2 | 0.709 |
HRI |
0.758 | -0.149 | -2 | 0.807 |
TAO3 |
0.758 | -0.043 | 1 | 0.155 |
PHKG2 |
0.758 | -0.084 | -3 | 0.751 |
MEKK2 |
0.757 | -0.111 | 2 | 0.791 |
MARK2 |
0.757 | -0.070 | 4 | 0.753 |
PAK2 |
0.757 | -0.113 | -2 | 0.715 |
ALK2 |
0.756 | -0.111 | -2 | 0.763 |
AKT1 |
0.756 | -0.021 | -3 | 0.665 |
MSK1 |
0.756 | -0.064 | -3 | 0.715 |
CAMK1G |
0.756 | -0.081 | -3 | 0.717 |
SNRK |
0.755 | -0.168 | 2 | 0.676 |
PRKX |
0.755 | -0.013 | -3 | 0.617 |
DRAK1 |
0.755 | -0.162 | 1 | 0.101 |
PERK |
0.754 | -0.168 | -2 | 0.797 |
MYLK4 |
0.754 | -0.082 | -2 | 0.709 |
MAPKAPK5 |
0.754 | -0.113 | -3 | 0.702 |
NEK5 |
0.754 | -0.156 | 1 | 0.116 |
MEKK3 |
0.753 | -0.178 | 1 | 0.129 |
BMPR1A |
0.753 | -0.086 | 1 | 0.092 |
SSTK |
0.753 | -0.064 | 4 | 0.824 |
PKCI |
0.753 | -0.051 | 2 | 0.722 |
MAP3K15 |
0.753 | -0.064 | 1 | 0.133 |
PLK3 |
0.752 | -0.151 | 2 | 0.740 |
TAO2 |
0.752 | -0.044 | 2 | 0.823 |
GSK3B |
0.752 | 0.035 | 4 | 0.405 |
AURA |
0.752 | -0.066 | -2 | 0.569 |
MEKK6 |
0.752 | -0.070 | 1 | 0.129 |
BRAF |
0.751 | -0.159 | -4 | 0.829 |
DCAMKL2 |
0.751 | -0.081 | -3 | 0.766 |
CHK1 |
0.751 | -0.120 | -3 | 0.793 |
HGK |
0.751 | -0.041 | 3 | 0.935 |
GRK2 |
0.751 | -0.116 | -2 | 0.669 |
MARK1 |
0.750 | -0.103 | 4 | 0.809 |
LKB1 |
0.750 | -0.060 | -3 | 0.822 |
PDK1 |
0.750 | -0.070 | 1 | 0.165 |
PKCE |
0.750 | -0.018 | 2 | 0.696 |
NEK11 |
0.750 | -0.135 | 1 | 0.148 |
TNIK |
0.749 | -0.023 | 3 | 0.929 |
PAK5 |
0.749 | -0.070 | -2 | 0.584 |
TLK1 |
0.749 | -0.169 | -2 | 0.788 |
SMMLCK |
0.749 | -0.070 | -3 | 0.777 |
GAK |
0.748 | -0.053 | 1 | 0.171 |
PKN1 |
0.748 | -0.052 | -3 | 0.694 |
MINK |
0.748 | -0.086 | 1 | 0.108 |
GCK |
0.748 | -0.074 | 1 | 0.130 |
CK1E |
0.748 | -0.055 | -3 | 0.437 |
KHS1 |
0.746 | -0.026 | 1 | 0.126 |
PKACA |
0.746 | -0.041 | -2 | 0.562 |
PASK |
0.746 | -0.075 | -3 | 0.795 |
PAK4 |
0.746 | -0.058 | -2 | 0.597 |
EEF2K |
0.745 | -0.045 | 3 | 0.918 |
P70S6K |
0.745 | -0.068 | -3 | 0.675 |
HASPIN |
0.745 | 0.026 | -1 | 0.675 |
BUB1 |
0.745 | -0.008 | -5 | 0.769 |
NEK4 |
0.745 | -0.150 | 1 | 0.106 |
AKT3 |
0.744 | -0.011 | -3 | 0.591 |
HPK1 |
0.744 | -0.073 | 1 | 0.133 |
NEK8 |
0.744 | -0.181 | 2 | 0.797 |
PBK |
0.743 | -0.040 | 1 | 0.154 |
LRRK2 |
0.742 | -0.034 | 2 | 0.822 |
KHS2 |
0.742 | -0.013 | 1 | 0.137 |
TTBK1 |
0.742 | -0.177 | 2 | 0.613 |
MST2 |
0.742 | -0.141 | 1 | 0.114 |
SGK1 |
0.741 | 0.004 | -3 | 0.572 |
LOK |
0.740 | -0.092 | -2 | 0.719 |
NEK1 |
0.740 | -0.141 | 1 | 0.101 |
CAMKK1 |
0.740 | -0.207 | -2 | 0.709 |
IRAK1 |
0.740 | -0.218 | -1 | 0.732 |
SBK |
0.740 | 0.080 | -3 | 0.541 |
CK2A2 |
0.739 | -0.079 | 1 | 0.086 |
VRK1 |
0.739 | -0.141 | 2 | 0.827 |
CK1D |
0.739 | -0.038 | -3 | 0.387 |
YSK1 |
0.739 | -0.096 | 2 | 0.789 |
CAMKK2 |
0.738 | -0.172 | -2 | 0.712 |
CAMK1D |
0.737 | -0.080 | -3 | 0.643 |
MRCKB |
0.737 | -0.036 | -3 | 0.692 |
DAPK3 |
0.736 | -0.079 | -3 | 0.747 |
CK1G1 |
0.736 | -0.099 | -3 | 0.434 |
CHK2 |
0.736 | -0.048 | -3 | 0.601 |
BIKE |
0.735 | -0.018 | 1 | 0.167 |
MST1 |
0.735 | -0.145 | 1 | 0.106 |
TAK1 |
0.735 | -0.188 | 1 | 0.105 |
NEK3 |
0.734 | -0.110 | 1 | 0.135 |
AAK1 |
0.734 | 0.020 | 1 | 0.178 |
MRCKA |
0.734 | -0.051 | -3 | 0.708 |
ROCK2 |
0.733 | -0.049 | -3 | 0.742 |
PDHK3_TYR |
0.733 | 0.125 | 4 | 0.883 |
GRK3 |
0.732 | -0.127 | -2 | 0.623 |
CK1A2 |
0.732 | -0.067 | -3 | 0.383 |
CAMK1A |
0.731 | -0.059 | -3 | 0.618 |
DMPK1 |
0.731 | -0.005 | -3 | 0.707 |
RIPK2 |
0.731 | -0.213 | 1 | 0.106 |
SLK |
0.730 | -0.110 | -2 | 0.671 |
MEK2 |
0.730 | -0.191 | 2 | 0.811 |
STK33 |
0.729 | -0.143 | 2 | 0.593 |
CK2A1 |
0.729 | -0.090 | 1 | 0.080 |
LIMK2_TYR |
0.729 | 0.127 | -3 | 0.868 |
DAPK1 |
0.728 | -0.086 | -3 | 0.726 |
MYO3B |
0.727 | -0.052 | 2 | 0.806 |
ASK1 |
0.727 | -0.103 | 1 | 0.134 |
PKMYT1_TYR |
0.726 | 0.125 | 3 | 0.896 |
PKG1 |
0.726 | -0.070 | -2 | 0.529 |
OSR1 |
0.726 | -0.080 | 2 | 0.785 |
TESK1_TYR |
0.726 | 0.025 | 3 | 0.920 |
TAO1 |
0.725 | -0.077 | 1 | 0.129 |
MYO3A |
0.725 | -0.065 | 1 | 0.126 |
TTK |
0.724 | -0.086 | -2 | 0.777 |
CRIK |
0.723 | -0.021 | -3 | 0.669 |
PLK2 |
0.722 | -0.113 | -3 | 0.737 |
PDHK4_TYR |
0.721 | 0.024 | 2 | 0.851 |
ROCK1 |
0.721 | -0.056 | -3 | 0.709 |
MAP2K4_TYR |
0.720 | -0.021 | -1 | 0.860 |
BMPR2_TYR |
0.719 | 0.005 | -1 | 0.861 |
MAP2K7_TYR |
0.718 | -0.099 | 2 | 0.840 |
MAP2K6_TYR |
0.718 | -0.005 | -1 | 0.863 |
PINK1_TYR |
0.717 | -0.122 | 1 | 0.179 |
PDHK1_TYR |
0.716 | -0.052 | -1 | 0.868 |
LIMK1_TYR |
0.716 | 0.000 | 2 | 0.838 |
ALPHAK3 |
0.714 | -0.104 | -1 | 0.739 |
MST1R |
0.714 | -0.091 | 3 | 0.859 |
CSF1R |
0.714 | -0.069 | 3 | 0.845 |
RET |
0.713 | -0.145 | 1 | 0.147 |
JAK2 |
0.713 | -0.109 | 1 | 0.156 |
TYK2 |
0.713 | -0.171 | 1 | 0.133 |
ROS1 |
0.713 | -0.098 | 3 | 0.840 |
JAK1 |
0.712 | -0.061 | 1 | 0.131 |
NEK10_TYR |
0.711 | -0.088 | 1 | 0.135 |
EPHA6 |
0.710 | -0.097 | -1 | 0.838 |
JAK3 |
0.710 | -0.103 | 1 | 0.144 |
TYRO3 |
0.709 | -0.139 | 3 | 0.859 |
TXK |
0.708 | -0.071 | 1 | 0.095 |
YES1 |
0.708 | -0.085 | -1 | 0.835 |
STLK3 |
0.708 | -0.172 | 1 | 0.104 |
TNNI3K_TYR |
0.707 | -0.036 | 1 | 0.161 |
LCK |
0.707 | -0.062 | -1 | 0.832 |
DDR1 |
0.705 | -0.131 | 4 | 0.806 |
TNK1 |
0.705 | -0.065 | 3 | 0.834 |
FGFR2 |
0.704 | -0.055 | 3 | 0.834 |
BLK |
0.704 | -0.056 | -1 | 0.831 |
EPHB4 |
0.704 | -0.139 | -1 | 0.811 |
FGFR1 |
0.704 | -0.043 | 3 | 0.812 |
ABL2 |
0.703 | -0.126 | -1 | 0.787 |
HCK |
0.703 | -0.117 | -1 | 0.828 |
TNK2 |
0.703 | -0.102 | 3 | 0.801 |
TEK |
0.702 | -0.016 | 3 | 0.794 |
ITK |
0.702 | -0.117 | -1 | 0.795 |
FGR |
0.702 | -0.164 | 1 | 0.106 |
YANK3 |
0.702 | -0.086 | 2 | 0.375 |
INSRR |
0.701 | -0.132 | 3 | 0.804 |
FLT3 |
0.700 | -0.155 | 3 | 0.857 |
PDGFRB |
0.700 | -0.182 | 3 | 0.861 |
KDR |
0.700 | -0.091 | 3 | 0.805 |
ABL1 |
0.700 | -0.135 | -1 | 0.780 |
KIT |
0.699 | -0.128 | 3 | 0.845 |
FER |
0.696 | -0.203 | 1 | 0.113 |
PDGFRA |
0.696 | -0.181 | 3 | 0.860 |
EPHA4 |
0.694 | -0.118 | 2 | 0.736 |
FYN |
0.694 | -0.073 | -1 | 0.816 |
SRMS |
0.694 | -0.186 | 1 | 0.091 |
EPHB1 |
0.694 | -0.183 | 1 | 0.098 |
CK1A |
0.694 | -0.085 | -3 | 0.291 |
WEE1_TYR |
0.694 | -0.079 | -1 | 0.726 |
DDR2 |
0.693 | -0.044 | 3 | 0.790 |
MET |
0.693 | -0.123 | 3 | 0.823 |
BMX |
0.693 | -0.113 | -1 | 0.710 |
FGFR3 |
0.692 | -0.078 | 3 | 0.806 |
AXL |
0.692 | -0.177 | 3 | 0.819 |
TEC |
0.691 | -0.139 | -1 | 0.724 |
BTK |
0.691 | -0.188 | -1 | 0.766 |
MERTK |
0.691 | -0.164 | 3 | 0.809 |
EPHB2 |
0.691 | -0.169 | -1 | 0.791 |
FRK |
0.691 | -0.133 | -1 | 0.831 |
EPHB3 |
0.690 | -0.188 | -1 | 0.797 |
ALK |
0.689 | -0.162 | 3 | 0.776 |
FLT1 |
0.688 | -0.144 | -1 | 0.812 |
ERBB2 |
0.687 | -0.170 | 1 | 0.118 |
EGFR |
0.686 | -0.113 | 1 | 0.100 |
INSR |
0.686 | -0.158 | 3 | 0.789 |
FLT4 |
0.686 | -0.155 | 3 | 0.801 |
LYN |
0.685 | -0.130 | 3 | 0.783 |
EPHA7 |
0.685 | -0.147 | 2 | 0.738 |
LTK |
0.685 | -0.178 | 3 | 0.789 |
NTRK2 |
0.684 | -0.208 | 3 | 0.804 |
SRC |
0.684 | -0.113 | -1 | 0.803 |
EPHA1 |
0.684 | -0.167 | 3 | 0.806 |
NTRK1 |
0.682 | -0.231 | -1 | 0.795 |
MUSK |
0.682 | -0.129 | 1 | 0.086 |
PTK6 |
0.681 | -0.217 | -1 | 0.713 |
NTRK3 |
0.681 | -0.169 | -1 | 0.747 |
PTK2B |
0.681 | -0.132 | -1 | 0.753 |
EPHA3 |
0.680 | -0.169 | 2 | 0.712 |
EPHA8 |
0.677 | -0.138 | -1 | 0.785 |
FGFR4 |
0.676 | -0.126 | -1 | 0.737 |
PTK2 |
0.675 | -0.073 | -1 | 0.788 |
MATK |
0.675 | -0.134 | -1 | 0.699 |
ERBB4 |
0.673 | -0.099 | 1 | 0.094 |
CSK |
0.673 | -0.169 | 2 | 0.748 |
EPHA5 |
0.673 | -0.176 | 2 | 0.719 |
SYK |
0.672 | -0.105 | -1 | 0.766 |
YANK2 |
0.669 | -0.104 | 2 | 0.389 |
IGF1R |
0.668 | -0.159 | 3 | 0.725 |
CK1G3 |
0.667 | -0.097 | -3 | 0.240 |
EPHA2 |
0.665 | -0.154 | -1 | 0.754 |
ZAP70 |
0.657 | -0.090 | -1 | 0.683 |
FES |
0.653 | -0.162 | -1 | 0.681 |
CK1G2 |
0.649 | -0.095 | -3 | 0.341 |