Motif 6 (n=230)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYK5 | None | S218 | ochoa | Uncharacterized protein | None |
| A0A0G2JLL6 | None | S90 | ochoa | Proline-rich transmembrane protein 2 | None |
| A0A0U1RQJ8 | ATRIP | S331 | ochoa | ATR interacting protein | None |
| A1L390 | PLEKHG3 | S1040 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| B0YJ81 | HACD1 | S30 | ochoa | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A) | [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.; FUNCTION: [Isoform 2]: In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum. {ECO:0000269|PubMed:22067203}. |
| C9J798 | RASA4B | S760 | ochoa | Ras GTPase-activating protein 4B | Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}. |
| C9JH25 | PRRT4 | S641 | ochoa | Proline-rich transmembrane protein 4 | None |
| F8VUJ3 | POC1B-GALNT4 | S27 | ochoa | Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) | None |
| K7EQG2 | None | S98 | ochoa | Uncharacterized protein | None |
| O00192 | ARVCF | S864 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00425 | IGF2BP3 | S184 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O14654 | IRS4 | S1061 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S2274 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14827 | RASGRF2 | S848 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O15049 | N4BP3 | S159 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15054 | KDM6B | S224 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
| O15085 | ARHGEF11 | S1480 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43315 | AQP9 | S222 | psp | Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity). {ECO:0000250|UniProtKB:P56627, ECO:0000250|UniProtKB:Q9JJJ3, ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:26837049, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:35054513, ECO:0000269|PubMed:9514918}. |
| O43374 | RASA4 | S760 | ochoa | Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}. |
| O60229 | KALRN | S487 | psp | Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) | Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269|PubMed:10023074}. |
| O75170 | PPP6R2 | S877 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| O75420 | GIGYF1 | S406 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75427 | LRCH4 | S380 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75970 | MPDZ | S790 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O95049 | TJP3 | S164 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95153 | TSPOAP1 | S1383 | ochoa | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) | Required for synaptic transmission regulation (PubMed:33539324). It probably controls the recruitement of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release. {ECO:0000269|PubMed:33539324}. |
| O95210 | STBD1 | S61 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95613 | PCNT | S2352 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95644 | NFATC1 | S772 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95714 | HERC2 | S3462 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95825 | CRYZL1 | S143 | ochoa | Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Ferry endosomal RAB5 effector complex subunit 4) (Fy-4) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). {ECO:0000269|PubMed:37267905, ECO:0000269|PubMed:37267906}. |
| O95994 | AGR2 | S119 | ochoa | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) | Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}. |
| P02545 | LMNA | S22 | ochoa|psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04179 | SOD2 | S106 | psp | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}. |
| P09874 | PARP1 | S874 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10070 | GLI2 | S149 | psp | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10275 | AR | S258 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P10645 | CHGA | S207 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P10914 | IRF1 | S184 | psp | Interferon regulatory factor 1 (IRF-1) | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essentail role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}. |
| P11908 | PRPS2 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| P12270 | TPR | T2116 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P14316 | IRF2 | S155 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
| P15923 | TCF3 | S139 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P17302 | GJA1 | S255 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P18858 | LIG1 | S76 | ochoa|psp | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P19838 | NFKB1 | S851 | ochoa | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P21359 | NF1 | S2802 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P23771 | GATA3 | S115 | ochoa | Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}. |
| P25054 | APC | S2512 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26639 | TARS1 | S339 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P27987 | ITPKB | S120 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30307 | CDC25C | S64 | ochoa | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P35568 | IRS1 | S1078 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35680 | HNF1B | S49 | ochoa | Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1) | Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:17924661, PubMed:7900999). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). {ECO:0000250|UniProtKB:Q03365, ECO:0000269|PubMed:17924661, ECO:0000269|PubMed:24204001, ECO:0000269|PubMed:7900999}. |
| P35968 | KDR | S229 | psp | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| P37287 | PIGA | S21 | ochoa | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A) | Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. {ECO:0000305|PubMed:16162815}. |
| P40222 | TXLNA | S489 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P42858 | HTT | S1199 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P48200 | IREB2 | S157 | psp | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}. |
| P49815 | TSC2 | S664 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50747 | HLCS | S299 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P54845 | NRL | S91 | psp | Neural retina-specific leucine zipper protein (NRL) | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds to the rhodopsin promoter in a sequence-specific manner (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}. |
| P55196 | AFDN | S391 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P60891 | PRPS1 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P78347 | GTF2I | S210 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q01094 | E2F1 | S375 | ochoa|psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
| Q01196 | RUNX1 | S21 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q04637 | EIF4G1 | S1092 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q13033 | STRN3 | S335 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13370 | PDE3B | S514 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13387 | MAPK8IP2 | S251 | ochoa | C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}. |
| Q13506 | NAB1 | S174 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q13625 | TP53BP2 | S569 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13895 | BYSL | S414 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q13905 | RAPGEF1 | S412 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14151 | SAFB2 | S832 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14186 | TFDP1 | S23 | ochoa|psp | Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}. |
| Q14188 | TFDP2 | S24 | ochoa | Transcription factor Dp-2 (E2F dimerization partner 2) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000305|PubMed:20176812}. |
| Q14526 | HIC1 | S713 | psp | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14676 | MDC1 | S108 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14699 | RFTN1 | S521 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14739 | LBR | S357 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q15742 | NAB2 | S479 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15788 | NCOA1 | S1250 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q16254 | E2F4 | S384 | psp | Transcription factor E2F4 (E2F-4) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Q16512 | PKN1 | S916 | ochoa|psp | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q16690 | DUSP5 | S346 | psp | Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3) | Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. {ECO:0000269|PubMed:7961985}. |
| Q17R89 | ARHGAP44 | S596 | ochoa | Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}. |
| Q17R98 | ZNF827 | S102 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q1ED39 | KNOP1 | S387 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q2LD37 | BLTP1 | S4097 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2LD37 | BLTP1 | S4308 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q32MK0 | MYLK3 | S401 | ochoa | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q49AM3 | TTC31 | S434 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q4KMQ1 | TPRN | S222 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q53T59 | HS1BP3 | S249 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5D0E6 | DALRD3 | S209 | ochoa | DALR anticodon-binding domain-containing protein 3 | Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B. {ECO:0000269|PubMed:32427860}. |
| Q5JR12 | PPM1J | S76 | ochoa | Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) | None |
| Q5JSZ5 | PRRC2B | S194 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SXM2 | SNAPC4 | S599 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5U5Q3 | MEX3C | S545 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5VST9 | OBSCN | S747 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VV41 | ARHGEF16 | S174 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VYS4 | MEDAG | S274 | ochoa | Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4) | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}. |
| Q63HR2 | TNS2 | S941 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q6IQ26 | DENND5A | S739 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6NUJ5 | PWWP2B | S447 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6NYC8 | PPP1R18 | S145 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6NYC8 | PPP1R18 | S195 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6NYC8 | PPP1R18 | S224 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P3S6 | FBXO42 | S429 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PK04 | CCDC137 | S233 | ochoa | Coiled-coil domain-containing protein 137 | None |
| Q6W2J9 | BCOR | S389 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZMQ8 | AATK | S495 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
| Q6ZRV2 | FAM83H | S974 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZU35 | CRACD | S556 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUT9 | DENND5B | S724 | ochoa | DENN domain-containing protein 5B (Rab6IP1-like protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6ZVF9 | GPRIN3 | S57 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q6ZVM7 | TOM1L2 | S160 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q75VX8 | GAREM2 | S735 | ochoa | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. {ECO:0000250}. |
| Q7Z2K8 | GPRIN1 | S436 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z6L0 | PRRT2 | S90 | ochoa | Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) | As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation. {ECO:0000250|UniProtKB:E9PUL5}. |
| Q86SJ2 | AMIGO2 | S446 | ochoa | Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
| Q86U44 | METTL3 | S525 | psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86UU0 | BCL9L | S750 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S1454 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86X10 | RALGAPB | S1320 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q8HWS3 | RFX6 | S21 | ochoa | DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). {ECO:0000269|PubMed:20148032, ECO:0000269|PubMed:25497100}. |
| Q8IVF2 | AHNAK2 | S4897 | ochoa | Protein AHNAK2 | None |
| Q8IVT2 | MISP | S430 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IW93 | ARHGEF19 | S336 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IY67 | RAVER1 | S524 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IY92 | SLX4 | S1075 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYD8 | FANCM | S1322 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IZ73 | RPUSD2 | S68 | ochoa | Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
| Q8N1F7 | NUP93 | S364 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N1G0 | ZNF687 | S374 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N2R0 | OSR2 | S140 | ochoa | Protein odd-skipped-related 2 | May be involved in the development of the mandibular molar tooth germ at the bud stage. {ECO:0000250|UniProtKB:Q91ZD1}. |
| Q8N5C8 | TAB3 | S359 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NDV7 | TNRC6A | S1372 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEY1 | NAV1 | S1405 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFF5 | FLAD1 | S106 | ochoa | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}. |
| Q8NFF5 | FLAD1 | S563 | ochoa | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}. |
| Q8NI36 | WDR36 | S863 | ochoa | WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in the nucleolar processing of SSU 18S rRNA (PubMed:21051332, PubMed:34516797). Involved in T-cell activation and highly coregulated with IL2 (PubMed:15177553). {ECO:0000269|PubMed:15177553, ECO:0000269|PubMed:21051332, ECO:0000269|PubMed:34516797}. |
| Q8TB72 | PUM2 | S82 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TBB5 | KLHDC4 | S222 | ochoa | Kelch domain-containing protein 4 | None |
| Q8TC05 | MDM1 | S314 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TC44 | POC1B | S27 | ochoa | POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Acts as a positive regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:37934472}. |
| Q8TDM6 | DLG5 | S37 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TE68 | EPS8L1 | S631 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TEK3 | DOT1L | S297 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TER5 | ARHGEF40 | S401 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TER5 | ARHGEF40 | S1438 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TEW8 | PARD3B | S990 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8WUF5 | PPP1R13L | S567 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WV44 | TRIM41 | S447 | ochoa | E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) | E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). {ECO:0000250|UniProtKB:Q5NCC3, ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016, ECO:0000269|PubMed:33378676}. |
| Q8WXE1 | ATRIP | S518 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WXF1 | PSPC1 | S164 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Q8WYQ5 | DGCR8 | S153 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92628 | KIAA0232 | S1117 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92870 | APBB2 | S123 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q92918 | MAP4K1 | S421 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q93084 | ATP2A3 | S662 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q969R5 | L3MBTL2 | S73 | ochoa | Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}. |
| Q969V6 | MRTFA | S511 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AQ6 | PBXIP1 | S355 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96DY7 | MTBP | S639 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
| Q96FF7 | MISP3 | S26 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96GZ6 | SLC41A3 | S27 | ochoa | Solute carrier family 41 member 3 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane. {ECO:0000269|PubMed:27302215}. |
| Q96JQ2 | CLMN | S157 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96LT9 | RNPC3 | S21 | ochoa | RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) | Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269|PubMed:16096647, ECO:0000269|PubMed:19447915, ECO:0000269|PubMed:24480542, ECO:0000269|PubMed:29255062}. |
| Q96PN7 | TRERF1 | S715 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96RK0 | CIC | S301 | ochoa|psp | Protein capicua homolog | Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}. |
| Q96RT7 | TUBGCP6 | S1381 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RU7 | TRIB3 | S51 | ochoa | Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B) | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15775988, PubMed:15781252). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15775988, PubMed:15781252). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15775988, PubMed:15781252). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}. |
| Q96S53 | TESK2 | S479 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
| Q96S99 | PLEKHF1 | S197 | ochoa | Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15) | May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}. |
| Q96T37 | RBM15 | S294 | ochoa|psp | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99958 | FOXC2 | S288 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BRD0 | BUD13 | S375 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRS8 | LARP6 | S51 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BT81 | SOX7 | S166 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9BUH8 | BEGAIN | S502 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BWG6 | SCNM1 | S144 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
| Q9BX79 | STRA6 | S404 | ochoa | Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) | Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:18316031, PubMed:22665496, PubMed:9452451). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031). {ECO:0000269|PubMed:18316031, ECO:0000269|PubMed:21901792, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:9452451, ECO:0000305}. |
| Q9C0A6 | SETD5 | S1043 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0C2 | TNKS1BP1 | S1385 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C7 | AMBRA1 | S1227 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9GZT9 | EGLN1 | S174 | ochoa | Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) | Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. {ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:21792862, ECO:0000269|PubMed:25129147}. |
| Q9H093 | NUAK2 | S430 | ochoa | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H0X9 | OSBPL5 | S44 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H2D6 | TRIOBP | S1949 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H611 | PIF1 | S27 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
| Q9H7N4 | SCAF1 | S30 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8X2 | IPPK | S282 | ochoa | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
| Q9H972 | C14orf93 | S224 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9H9J4 | USP42 | S1007 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HB07 | MYG1 | S120 | ochoa | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HCE1 | MOV10 | S969 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9NRF2 | SH2B1 | S96 | ochoa|psp | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
| Q9NRI5 | DISC1 | S58 | psp | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9NRL2 | BAZ1A | S1353 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NVD7 | PARVA | S62 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NWK9 | ZNHIT6 | S25 | ochoa | Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) | Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. {ECO:0000269|PubMed:17636026}. |
| Q9NZU7 | CABP1 | S176 | ochoa | Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:O88751, ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}. |
| Q9P206 | NHSL3 | S280 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P209 | CEP72 | S237 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9P260 | RELCH | S56 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P2F5 | STOX2 | S886 | ochoa | Storkhead-box protein 2 | None |
| Q9UBZ9 | REV1 | S301 | ochoa | DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. |
| Q9UHD2 | TBK1 | S527 | psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UHX1 | PUF60 | S112 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UIF9 | BAZ2A | S1783 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKK3 | PARP4 | S1288 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UM11 | FZR1 | S151 | ochoa|psp | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. |
| Q9UMN6 | KMT2B | S821 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPN4 | CEP131 | S381 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPT6 | MAPK8IP3 | S676 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UPY3 | DICER1 | S1470 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9Y2L5 | TRAPPC8 | S971 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y2U8 | LEMD3 | S27 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2X9 | ZNF281 | S651 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y4P3 | TBL2 | S340 | ochoa | Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) | None |
| Q9Y5Q9 | GTF3C3 | S282 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| Q9Y6Q9 | NCOA3 | S728 | ochoa|psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q15084 | PDIA6 | S389 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P33316 | DUT | S120 | Sugiyama | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| Q9NQR4 | NIT2 | S133 | Sugiyama | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| Q92630 | DYRK2 | S471 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| P50570 | DNM2 | S357 | Sugiyama | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.000021 | 4.673 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.000024 | 4.620 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.000027 | 4.572 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000013 | 4.888 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.000061 | 4.217 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.000071 | 4.149 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.000094 | 4.028 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.000138 | 3.861 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.000184 | 3.736 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.000184 | 3.736 |
| R-HSA-1538133 | G0 and Early G1 | 0.000416 | 3.381 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.000326 | 3.487 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.000416 | 3.381 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000390 | 3.409 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000387 | 3.412 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000470 | 3.328 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.000560 | 3.252 |
| R-HSA-73887 | Death Receptor Signaling | 0.000549 | 3.260 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.000551 | 3.259 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000801 | 3.096 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.000897 | 3.047 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.000975 | 3.011 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.001031 | 2.987 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.001066 | 2.972 |
| R-HSA-432030 | Transport of glycerol from adipocytes to the liver by Aquaporins | 0.001123 | 2.950 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.001311 | 2.882 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.001311 | 2.882 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.001513 | 2.820 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.001513 | 2.820 |
| R-HSA-2559583 | Cellular Senescence | 0.001626 | 2.789 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.001666 | 2.778 |
| R-HSA-69236 | G1 Phase | 0.001666 | 2.778 |
| R-HSA-1640170 | Cell Cycle | 0.001788 | 2.748 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.001976 | 2.704 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.001911 | 2.719 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.001937 | 2.713 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.002134 | 2.671 |
| R-HSA-212436 | Generic Transcription Pathway | 0.002589 | 2.587 |
| R-HSA-74160 | Gene expression (Transcription) | 0.002732 | 2.564 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.002912 | 2.536 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.003359 | 2.474 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.003864 | 2.413 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.004301 | 2.366 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.005434 | 2.265 |
| R-HSA-68911 | G2 Phase | 0.005862 | 2.232 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.006355 | 2.197 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.006640 | 2.178 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.007136 | 2.147 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.008164 | 2.088 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.007931 | 2.101 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.007931 | 2.101 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.010026 | 1.999 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.013880 | 1.858 |
| R-HSA-196025 | Formation of annular gap junctions | 0.013880 | 1.858 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.013313 | 1.876 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.013880 | 1.858 |
| R-HSA-9839394 | TGFBR3 expression | 0.014173 | 1.849 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.014583 | 1.836 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.015956 | 1.797 |
| R-HSA-190873 | Gap junction degradation | 0.016346 | 1.787 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 0.016346 | 1.787 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.019949 | 1.700 |
| R-HSA-2586552 | Signaling by Leptin | 0.018984 | 1.722 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.020588 | 1.686 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.020588 | 1.686 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.020022 | 1.698 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.021789 | 1.662 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.024753 | 1.606 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.026167 | 1.582 |
| R-HSA-162582 | Signal Transduction | 0.026545 | 1.576 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.026308 | 1.580 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.027381 | 1.563 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.029330 | 1.533 |
| R-HSA-2262752 | Cellular responses to stress | 0.029774 | 1.526 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.029909 | 1.524 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.031223 | 1.506 |
| R-HSA-9830369 | Kidney development | 0.033951 | 1.469 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.031138 | 1.507 |
| R-HSA-5357801 | Programmed Cell Death | 0.030576 | 1.515 |
| R-HSA-9918449 | Defective visual phototransduction due to STRA6 loss of function | 0.062317 | 1.205 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.077283 | 1.112 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.077283 | 1.112 |
| R-HSA-191650 | Regulation of gap junction activity | 0.092010 | 1.036 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.092010 | 1.036 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.106503 | 0.973 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.106503 | 0.973 |
| R-HSA-74713 | IRS activation | 0.106503 | 0.973 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.106503 | 0.973 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.120766 | 0.918 |
| R-HSA-165160 | PDE3B signalling | 0.120766 | 0.918 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.120766 | 0.918 |
| R-HSA-109703 | PKB-mediated events | 0.120766 | 0.918 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.120766 | 0.918 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.134801 | 0.870 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.134801 | 0.870 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.038096 | 1.419 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.148614 | 0.828 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.148614 | 0.828 |
| R-HSA-112412 | SOS-mediated signalling | 0.148614 | 0.828 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.162207 | 0.790 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.061991 | 1.208 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.075402 | 1.123 |
| R-HSA-4839744 | Signaling by APC mutants | 0.201702 | 0.695 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.201702 | 0.695 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.201702 | 0.695 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.201702 | 0.695 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.080061 | 1.097 |
| R-HSA-429947 | Deadenylation of mRNA | 0.084806 | 1.072 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.214451 | 0.669 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.226996 | 0.644 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.226996 | 0.644 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.239342 | 0.621 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.114890 | 0.940 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.120139 | 0.920 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.120139 | 0.920 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.263448 | 0.579 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.263448 | 0.579 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.130810 | 0.883 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.130810 | 0.883 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.136225 | 0.866 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.275214 | 0.560 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.275214 | 0.560 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.042947 | 1.367 |
| R-HSA-380287 | Centrosome maturation | 0.046216 | 1.335 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.147198 | 0.832 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.286793 | 0.542 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.091586 | 1.038 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.298188 | 0.526 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.169641 | 0.770 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.175340 | 0.756 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.107781 | 0.967 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.107781 | 0.967 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.181069 | 0.742 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.072837 | 1.138 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.117995 | 0.928 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.239520 | 0.621 |
| R-HSA-72649 | Translation initiation complex formation | 0.263211 | 0.580 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.275067 | 0.561 |
| R-HSA-1989781 | PPARA activates gene expression | 0.303913 | 0.517 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.047249 | 1.326 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.114890 | 0.940 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.214331 | 0.669 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.148614 | 0.828 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.251492 | 0.599 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.286913 | 0.542 |
| R-HSA-9831926 | Nephron development | 0.309401 | 0.509 |
| R-HSA-198203 | PI3K/AKT activation | 0.188747 | 0.724 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.054964 | 1.260 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.263448 | 0.579 |
| R-HSA-112399 | IRS-mediated signalling | 0.088478 | 1.053 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.120766 | 0.918 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.148614 | 0.828 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.045583 | 1.341 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.162207 | 0.790 |
| R-HSA-9609690 | HCMV Early Events | 0.265970 | 0.575 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.152751 | 0.816 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.043233 | 1.364 |
| R-HSA-4641265 | Repression of WNT target genes | 0.226996 | 0.644 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.233611 | 0.632 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.152751 | 0.816 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.106503 | 0.973 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.106503 | 0.973 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.034548 | 1.462 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.162207 | 0.790 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.175584 | 0.756 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.175584 | 0.756 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.214451 | 0.669 |
| R-HSA-109704 | PI3K Cascade | 0.068047 | 1.167 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.298188 | 0.526 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.309401 | 0.509 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.185708 | 0.731 |
| R-HSA-190828 | Gap junction trafficking | 0.204239 | 0.690 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.134801 | 0.870 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.148614 | 0.828 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.239342 | 0.621 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.263448 | 0.579 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.139432 | 0.856 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.292829 | 0.533 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.044564 | 1.351 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.094541 | 1.024 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.248078 | 0.605 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.038680 | 1.413 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.053561 | 1.271 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.300324 | 0.522 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.050944 | 1.293 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.111146 | 0.954 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 0.047111 | 1.327 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.062317 | 1.205 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.062317 | 1.205 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.062317 | 1.205 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.077283 | 1.112 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.092010 | 1.036 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.188747 | 0.724 |
| R-HSA-192814 | vRNA Synthesis | 0.201702 | 0.695 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.214451 | 0.669 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.214451 | 0.669 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.214451 | 0.669 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.089634 | 1.048 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.226996 | 0.644 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.263448 | 0.579 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.263448 | 0.579 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.158344 | 0.800 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.309401 | 0.509 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.309401 | 0.509 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.210084 | 0.678 |
| R-HSA-69206 | G1/S Transition | 0.190261 | 0.721 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.309401 | 0.509 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.286793 | 0.542 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.130810 | 0.883 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.286793 | 0.542 |
| R-HSA-74749 | Signal attenuation | 0.188747 | 0.724 |
| R-HSA-69481 | G2/M Checkpoints | 0.196748 | 0.706 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.173771 | 0.760 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.120766 | 0.918 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.148614 | 0.828 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.175584 | 0.756 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.188747 | 0.724 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.188747 | 0.724 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.214451 | 0.669 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.251492 | 0.599 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.125447 | 0.902 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.136225 | 0.866 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.286793 | 0.542 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.292829 | 0.533 |
| R-HSA-196780 | Biotin transport and metabolism | 0.263448 | 0.579 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.226876 | 0.644 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.143656 | 0.843 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.239342 | 0.621 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.282563 | 0.549 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.303913 | 0.517 |
| R-HSA-211000 | Gene Silencing by RNA | 0.044589 | 1.351 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.047111 | 1.327 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 0.047111 | 1.327 |
| R-HSA-165158 | Activation of AKT2 | 0.106503 | 0.973 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.120766 | 0.918 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.188747 | 0.724 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.201702 | 0.695 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.214451 | 0.669 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.214451 | 0.669 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.251492 | 0.599 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.251492 | 0.599 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.185708 | 0.731 |
| R-HSA-191859 | snRNP Assembly | 0.292829 | 0.533 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.292829 | 0.533 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.304641 | 0.516 |
| R-HSA-8939211 | ESR-mediated signaling | 0.234948 | 0.629 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.304641 | 0.516 |
| R-HSA-9830364 | Formation of the nephric duct | 0.089634 | 1.048 |
| R-HSA-9945266 | Differentiation of T cells | 0.041776 | 1.379 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.041776 | 1.379 |
| R-HSA-5693538 | Homology Directed Repair | 0.063658 | 1.196 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.227711 | 0.643 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.196026 | 0.708 |
| R-HSA-9842663 | Signaling by LTK | 0.226996 | 0.644 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.263448 | 0.579 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.147003 | 0.833 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.221822 | 0.654 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.291257 | 0.536 |
| R-HSA-9612973 | Autophagy | 0.307507 | 0.512 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.134801 | 0.870 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.251492 | 0.599 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.035366 | 1.451 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.141688 | 0.849 |
| R-HSA-73894 | DNA Repair | 0.270064 | 0.569 |
| R-HSA-450294 | MAP kinase activation | 0.304641 | 0.516 |
| R-HSA-195721 | Signaling by WNT | 0.143561 | 0.843 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.278164 | 0.556 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.091586 | 1.038 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.227299 | 0.643 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.147198 | 0.832 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.057475 | 1.241 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.181069 | 0.742 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.092010 | 1.036 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.106503 | 0.973 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.120766 | 0.918 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.120766 | 0.918 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.041776 | 1.379 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.226996 | 0.644 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.175340 | 0.756 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.175340 | 0.756 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.181069 | 0.742 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.248078 | 0.605 |
| R-HSA-1632852 | Macroautophagy | 0.250790 | 0.601 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.152930 | 0.816 |
| R-HSA-9659379 | Sensory processing of sound | 0.053158 | 1.274 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.278913 | 0.555 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.041363 | 1.383 |
| R-HSA-4086398 | Ca2+ pathway | 0.042947 | 1.367 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.117995 | 0.928 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.180664 | 0.743 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.158217 | 0.801 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.257766 | 0.589 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.106503 | 0.973 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.175584 | 0.756 |
| R-HSA-448706 | Interleukin-1 processing | 0.175584 | 0.756 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.201702 | 0.695 |
| R-HSA-196843 | Vitamin B2 (riboflavin) metabolism | 0.251492 | 0.599 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.163975 | 0.785 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.215945 | 0.666 |
| R-HSA-9766229 | Degradation of CDH1 | 0.233611 | 0.632 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.285885 | 0.544 |
| R-HSA-69275 | G2/M Transition | 0.115474 | 0.938 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.049513 | 1.305 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.211894 | 0.674 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.162065 | 0.790 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.064572 | 1.190 |
| R-HSA-165159 | MTOR signalling | 0.192608 | 0.715 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.141168 | 0.850 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.286793 | 0.542 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.169641 | 0.770 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.304333 | 0.517 |
| R-HSA-170968 | Frs2-mediated activation | 0.239342 | 0.621 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.263448 | 0.579 |
| R-HSA-186712 | Regulation of beta-cell development | 0.094739 | 1.023 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.080061 | 1.097 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.098157 | 1.008 |
| R-HSA-68875 | Mitotic Prophase | 0.066942 | 1.174 |
| R-HSA-1266738 | Developmental Biology | 0.229332 | 0.640 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.075402 | 1.123 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.109702 | 0.960 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.251492 | 0.599 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.263448 | 0.579 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.034866 | 1.458 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.046216 | 1.335 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.085416 | 1.068 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.280992 | 0.551 |
| R-HSA-68886 | M Phase | 0.118335 | 0.927 |
| R-HSA-166520 | Signaling by NTRKs | 0.053402 | 1.272 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.130810 | 0.883 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.041776 | 1.379 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.233539 | 0.632 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.227176 | 0.644 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.075060 | 1.125 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.130810 | 0.883 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.226996 | 0.644 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.239342 | 0.621 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.298188 | 0.526 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.299971 | 0.523 |
| R-HSA-157118 | Signaling by NOTCH | 0.061152 | 1.214 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.072837 | 1.138 |
| R-HSA-169893 | Prolonged ERK activation events | 0.275214 | 0.560 |
| R-HSA-446728 | Cell junction organization | 0.206637 | 0.685 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.036867 | 1.433 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.251492 | 0.599 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.073641 | 1.133 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.298188 | 0.526 |
| R-HSA-71336 | Pentose phosphate pathway | 0.169641 | 0.770 |
| R-HSA-418990 | Adherens junctions interactions | 0.187288 | 0.727 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.299971 | 0.523 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.265970 | 0.575 |
| R-HSA-421270 | Cell-cell junction organization | 0.272228 | 0.565 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.193783 | 0.713 |
| R-HSA-4839726 | Chromatin organization | 0.266811 | 0.574 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.152751 | 0.816 |
| R-HSA-1500931 | Cell-Cell communication | 0.297995 | 0.526 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.186826 | 0.729 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.198805 | 0.702 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.198805 | 0.702 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.161988 | 0.791 |
| R-HSA-5620971 | Pyroptosis | 0.104579 | 0.981 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.198413 | 0.702 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.124246 | 0.906 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.155928 | 0.807 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.094541 | 1.024 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.136225 | 0.866 |
| R-HSA-69242 | S Phase | 0.053402 | 1.272 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.080061 | 1.097 |
| R-HSA-180786 | Extension of Telomeres | 0.292829 | 0.533 |
| R-HSA-75893 | TNF signaling | 0.275067 | 0.561 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.309401 | 0.509 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.084571 | 1.073 |
| R-HSA-913531 | Interferon Signaling | 0.205895 | 0.686 |
| R-HSA-5358508 | Mismatch Repair | 0.309401 | 0.509 |
| R-HSA-109581 | Apoptosis | 0.072605 | 1.139 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.146115 | 0.835 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.125447 | 0.902 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.038297 | 1.417 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.098157 | 1.008 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.099524 | 1.002 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.251357 | 0.600 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.068640 | 1.163 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.081613 | 1.088 |
| R-HSA-75153 | Apoptotic execution phase | 0.215945 | 0.666 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.204403 | 0.690 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.243855 | 0.613 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.310534 | 0.508 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.310763 | 0.508 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.311105 | 0.507 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.313065 | 0.504 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.313065 | 0.504 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.316416 | 0.500 |
| R-HSA-877300 | Interferon gamma signaling | 0.318313 | 0.497 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.320435 | 0.494 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.320435 | 0.494 |
| R-HSA-449836 | Other interleukin signaling | 0.320435 | 0.494 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.320435 | 0.494 |
| R-HSA-9834899 | Specification of the neural plate border | 0.320435 | 0.494 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.320435 | 0.494 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.320435 | 0.494 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.320435 | 0.494 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.321922 | 0.492 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.322287 | 0.492 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.328146 | 0.484 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.330544 | 0.481 |
| R-HSA-68882 | Mitotic Anaphase | 0.331045 | 0.480 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.331294 | 0.480 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.331294 | 0.480 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.331294 | 0.480 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.334194 | 0.476 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.339821 | 0.469 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.339821 | 0.469 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.341981 | 0.466 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.341981 | 0.466 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.341981 | 0.466 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.341981 | 0.466 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.341981 | 0.466 |
| R-HSA-5218859 | Regulated Necrosis | 0.345635 | 0.461 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.350265 | 0.456 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.351433 | 0.454 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.352497 | 0.453 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.352497 | 0.453 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.352497 | 0.453 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.352497 | 0.453 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.352497 | 0.453 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.352497 | 0.453 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.352497 | 0.453 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.357213 | 0.447 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.357213 | 0.447 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.357213 | 0.447 |
| R-HSA-448424 | Interleukin-17 signaling | 0.357213 | 0.447 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.357213 | 0.447 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.361088 | 0.442 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.362845 | 0.440 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.362845 | 0.440 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.362845 | 0.440 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.362845 | 0.440 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.362845 | 0.440 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.362845 | 0.440 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.362845 | 0.440 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.368717 | 0.433 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.372618 | 0.429 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.373029 | 0.428 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.373029 | 0.428 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.373029 | 0.428 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.374439 | 0.427 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.378709 | 0.422 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.379857 | 0.420 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.383051 | 0.417 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.383051 | 0.417 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.383051 | 0.417 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.383126 | 0.417 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.391421 | 0.407 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.391421 | 0.407 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.391421 | 0.407 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.391475 | 0.407 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.392913 | 0.406 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.392913 | 0.406 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.392913 | 0.406 |
| R-HSA-3214842 | HDMs demethylate histones | 0.392913 | 0.406 |
| R-HSA-2453864 | Retinoid cycle disease events | 0.392913 | 0.406 |
| R-HSA-2474795 | Diseases associated with visual transduction | 0.392913 | 0.406 |
| R-HSA-9675143 | Diseases of the neuronal system | 0.392913 | 0.406 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.392913 | 0.406 |
| R-HSA-168255 | Influenza Infection | 0.394308 | 0.404 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.398656 | 0.399 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.402618 | 0.395 |
| R-HSA-525793 | Myogenesis | 0.402618 | 0.395 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.402618 | 0.395 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.402716 | 0.395 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.408300 | 0.389 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.408300 | 0.389 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.412169 | 0.385 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.412169 | 0.385 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.412169 | 0.385 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.412169 | 0.385 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.412169 | 0.385 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.412169 | 0.385 |
| R-HSA-6806834 | Signaling by MET | 0.413859 | 0.383 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.419392 | 0.377 |
| R-HSA-9843745 | Adipogenesis | 0.421386 | 0.375 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.421567 | 0.375 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.421567 | 0.375 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.421567 | 0.375 |
| R-HSA-622312 | Inflammasomes | 0.421567 | 0.375 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.424898 | 0.372 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.424898 | 0.372 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.430377 | 0.366 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.430816 | 0.366 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.430816 | 0.366 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.430816 | 0.366 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.430816 | 0.366 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.430816 | 0.366 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.430816 | 0.366 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.435829 | 0.361 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.437289 | 0.359 |
| R-HSA-9609646 | HCMV Infection | 0.438353 | 0.358 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.439917 | 0.357 |
| R-HSA-112311 | Neurotransmitter clearance | 0.439917 | 0.357 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.439917 | 0.357 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.439917 | 0.357 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.441252 | 0.355 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.442103 | 0.354 |
| R-HSA-68877 | Mitotic Prometaphase | 0.444376 | 0.352 |
| R-HSA-162710 | Synthesis of glycosylphosphatidylinositol (GPI) | 0.448874 | 0.348 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.448874 | 0.348 |
| R-HSA-186763 | Downstream signal transduction | 0.448874 | 0.348 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.452012 | 0.345 |
| R-HSA-5688426 | Deubiquitination | 0.453934 | 0.343 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.457348 | 0.340 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.457687 | 0.339 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.457687 | 0.339 |
| R-HSA-69190 | DNA strand elongation | 0.457687 | 0.339 |
| R-HSA-9663891 | Selective autophagy | 0.462654 | 0.335 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.466361 | 0.331 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.466361 | 0.331 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.466361 | 0.331 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.466361 | 0.331 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.466361 | 0.331 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.466361 | 0.331 |
| R-HSA-73884 | Base Excision Repair | 0.473174 | 0.325 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.474896 | 0.323 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.474896 | 0.323 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.478614 | 0.320 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.483295 | 0.316 |
| R-HSA-190861 | Gap junction assembly | 0.483295 | 0.316 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.483295 | 0.316 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.483295 | 0.316 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.483295 | 0.316 |
| R-HSA-5205647 | Mitophagy | 0.483295 | 0.316 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.483295 | 0.316 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.483295 | 0.316 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.483569 | 0.316 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.491560 | 0.308 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.491560 | 0.308 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.491560 | 0.308 |
| R-HSA-187687 | Signalling to ERKs | 0.491560 | 0.308 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.491560 | 0.308 |
| R-HSA-8853659 | RET signaling | 0.499694 | 0.301 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.499694 | 0.301 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.499694 | 0.301 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.503976 | 0.298 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.507698 | 0.294 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.507698 | 0.294 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.507698 | 0.294 |
| R-HSA-8875878 | MET promotes cell motility | 0.515574 | 0.288 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.515574 | 0.288 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.515574 | 0.288 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.515680 | 0.288 |
| R-HSA-157579 | Telomere Maintenance | 0.518936 | 0.285 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.523325 | 0.281 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.523325 | 0.281 |
| R-HSA-201556 | Signaling by ALK | 0.523325 | 0.281 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.523856 | 0.281 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.523856 | 0.281 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.523856 | 0.281 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.528742 | 0.277 |
| R-HSA-9646399 | Aggrephagy | 0.530953 | 0.275 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.530953 | 0.275 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.530953 | 0.275 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.530953 | 0.275 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.530953 | 0.275 |
| R-HSA-5260271 | Diseases of Immune System | 0.530953 | 0.275 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.533594 | 0.273 |
| R-HSA-70171 | Glycolysis | 0.533594 | 0.273 |
| R-HSA-9610379 | HCMV Late Events | 0.535098 | 0.272 |
| R-HSA-162587 | HIV Life Cycle | 0.535098 | 0.272 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.538412 | 0.269 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.538458 | 0.269 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.538458 | 0.269 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.538458 | 0.269 |
| R-HSA-9711097 | Cellular response to starvation | 0.538929 | 0.268 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.543196 | 0.265 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.545844 | 0.263 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.545844 | 0.263 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.545844 | 0.263 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.545844 | 0.263 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.545844 | 0.263 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.552660 | 0.258 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.553113 | 0.257 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.553113 | 0.257 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.557340 | 0.254 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.557340 | 0.254 |
| R-HSA-8854214 | TBC/RABGAPs | 0.560265 | 0.252 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.561985 | 0.250 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.567304 | 0.246 |
| R-HSA-69239 | Synthesis of DNA | 0.571171 | 0.243 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.572913 | 0.242 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.574230 | 0.241 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.575711 | 0.240 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.575711 | 0.240 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.575711 | 0.240 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.580217 | 0.236 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.581046 | 0.236 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.581046 | 0.236 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.581046 | 0.236 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.581046 | 0.236 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.581046 | 0.236 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.581046 | 0.236 |
| R-HSA-9675135 | Diseases of DNA repair | 0.581046 | 0.236 |
| R-HSA-9679506 | SARS-CoV Infections | 0.581578 | 0.235 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.581873 | 0.235 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.587040 | 0.231 |
| R-HSA-437239 | Recycling pathway of L1 | 0.587753 | 0.231 |
| R-HSA-6803157 | Antimicrobial peptides | 0.589122 | 0.230 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.590606 | 0.229 |
| R-HSA-449147 | Signaling by Interleukins | 0.593261 | 0.227 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.593522 | 0.227 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.593522 | 0.227 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.594353 | 0.226 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.594353 | 0.226 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.597887 | 0.223 |
| R-HSA-73893 | DNA Damage Bypass | 0.600848 | 0.221 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.610772 | 0.214 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.613528 | 0.212 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.613528 | 0.212 |
| R-HSA-9864848 | Complex IV assembly | 0.613528 | 0.212 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.614996 | 0.211 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.619185 | 0.208 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.619185 | 0.208 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.619717 | 0.208 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.623340 | 0.205 |
| R-HSA-70326 | Glucose metabolism | 0.623340 | 0.205 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.625807 | 0.204 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.625807 | 0.204 |
| R-HSA-1221632 | Meiotic synapsis | 0.625807 | 0.204 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.627459 | 0.202 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.631544 | 0.200 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.631544 | 0.200 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.631800 | 0.199 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.631800 | 0.199 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.633376 | 0.198 |
| R-HSA-73886 | Chromosome Maintenance | 0.639608 | 0.194 |
| R-HSA-3371556 | Cellular response to heat stress | 0.639608 | 0.194 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.640025 | 0.194 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.643501 | 0.191 |
| R-HSA-5578775 | Ion homeostasis | 0.643501 | 0.191 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.643501 | 0.191 |
| R-HSA-177929 | Signaling by EGFR | 0.643501 | 0.191 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.643588 | 0.191 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.643588 | 0.191 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.647628 | 0.189 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.648147 | 0.188 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.651444 | 0.186 |
| R-HSA-5617833 | Cilium Assembly | 0.654527 | 0.184 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.655029 | 0.184 |
| R-HSA-194138 | Signaling by VEGF | 0.659163 | 0.181 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.665803 | 0.177 |
| R-HSA-379724 | tRNA Aminoacylation | 0.665803 | 0.177 |
| R-HSA-211976 | Endogenous sterols | 0.671158 | 0.173 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.676427 | 0.170 |
| R-HSA-9707616 | Heme signaling | 0.676427 | 0.170 |
| R-HSA-186797 | Signaling by PDGF | 0.676427 | 0.170 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.677861 | 0.169 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.681612 | 0.166 |
| R-HSA-373755 | Semaphorin interactions | 0.681612 | 0.166 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.681887 | 0.166 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.686715 | 0.163 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.691736 | 0.160 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.691736 | 0.160 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.693406 | 0.159 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.693976 | 0.159 |
| R-HSA-72172 | mRNA Splicing | 0.699734 | 0.155 |
| R-HSA-196807 | Nicotinate metabolism | 0.701539 | 0.154 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.701539 | 0.154 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.701539 | 0.154 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.706323 | 0.151 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.712753 | 0.147 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.715664 | 0.145 |
| R-HSA-6807070 | PTEN Regulation | 0.716062 | 0.145 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.716986 | 0.144 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.720222 | 0.143 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.720222 | 0.143 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.720222 | 0.143 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.720222 | 0.143 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.724708 | 0.140 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.724708 | 0.140 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.724708 | 0.140 |
| R-HSA-8953854 | Metabolism of RNA | 0.726601 | 0.139 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.728983 | 0.137 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.729122 | 0.137 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.729122 | 0.137 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.735256 | 0.134 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.737741 | 0.132 |
| R-HSA-917937 | Iron uptake and transport | 0.737741 | 0.132 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.737741 | 0.132 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.746085 | 0.127 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.750158 | 0.125 |
| R-HSA-216083 | Integrin cell surface interactions | 0.750158 | 0.125 |
| R-HSA-9758941 | Gastrulation | 0.750399 | 0.125 |
| R-HSA-9675108 | Nervous system development | 0.756458 | 0.121 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.758109 | 0.120 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.758109 | 0.120 |
| R-HSA-9833482 | PKR-mediated signaling | 0.758109 | 0.120 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.759124 | 0.120 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.759124 | 0.120 |
| R-HSA-162906 | HIV Infection | 0.760137 | 0.119 |
| R-HSA-69306 | DNA Replication | 0.761973 | 0.118 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.767245 | 0.115 |
| R-HSA-72312 | rRNA processing | 0.771889 | 0.112 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.775787 | 0.110 |
| R-HSA-1500620 | Meiosis | 0.776902 | 0.110 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.776902 | 0.110 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.784005 | 0.106 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.787472 | 0.104 |
| R-HSA-156902 | Peptide chain elongation | 0.790883 | 0.102 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.797543 | 0.098 |
| R-HSA-202424 | Downstream TCR signaling | 0.797543 | 0.098 |
| R-HSA-5619102 | SLC transporter disorders | 0.798897 | 0.098 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.800793 | 0.096 |
| R-HSA-8957322 | Metabolism of steroids | 0.805045 | 0.094 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.807138 | 0.093 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.807138 | 0.093 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.807138 | 0.093 |
| R-HSA-72306 | tRNA processing | 0.808476 | 0.092 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.810235 | 0.091 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.813282 | 0.090 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.816281 | 0.088 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.819231 | 0.087 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.819231 | 0.087 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.827802 | 0.082 |
| R-HSA-3214847 | HATs acetylate histones | 0.830568 | 0.081 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.830568 | 0.081 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.835969 | 0.078 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.838604 | 0.076 |
| R-HSA-192823 | Viral mRNA Translation | 0.841197 | 0.075 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.846260 | 0.072 |
| R-HSA-418346 | Platelet homeostasis | 0.851162 | 0.070 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.853554 | 0.069 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.854236 | 0.068 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.857861 | 0.067 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.858224 | 0.066 |
| R-HSA-202403 | TCR signaling | 0.860503 | 0.065 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.860503 | 0.065 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.871363 | 0.060 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.873177 | 0.059 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.875467 | 0.058 |
| R-HSA-373760 | L1CAM interactions | 0.877470 | 0.057 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.887014 | 0.052 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.890620 | 0.050 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.890620 | 0.050 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.891046 | 0.050 |
| R-HSA-422475 | Axon guidance | 0.894667 | 0.048 |
| R-HSA-1474165 | Reproduction | 0.905482 | 0.043 |
| R-HSA-5576891 | Cardiac conduction | 0.907004 | 0.042 |
| R-HSA-9909396 | Circadian clock | 0.908501 | 0.042 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.914953 | 0.039 |
| R-HSA-199991 | Membrane Trafficking | 0.915534 | 0.038 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.918332 | 0.037 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.925916 | 0.033 |
| R-HSA-1280218 | Adaptive Immune System | 0.927829 | 0.033 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.929362 | 0.032 |
| R-HSA-2187338 | Visual phototransduction | 0.930577 | 0.031 |
| R-HSA-9824446 | Viral Infection Pathways | 0.931435 | 0.031 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.933881 | 0.030 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.934947 | 0.029 |
| R-HSA-388396 | GPCR downstream signalling | 0.944106 | 0.025 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.947343 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.947421 | 0.023 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.949077 | 0.023 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.949851 | 0.022 |
| R-HSA-418555 | G alpha (s) signalling events | 0.953770 | 0.021 |
| R-HSA-112316 | Neuronal System | 0.955885 | 0.020 |
| R-HSA-611105 | Respiratory electron transport | 0.958749 | 0.018 |
| R-HSA-983712 | Ion channel transport | 0.965516 | 0.015 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.972553 | 0.012 |
| R-HSA-168256 | Immune System | 0.972987 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 0.973573 | 0.012 |
| R-HSA-72766 | Translation | 0.976615 | 0.010 |
| R-HSA-397014 | Muscle contraction | 0.976684 | 0.010 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.976684 | 0.010 |
| R-HSA-8951664 | Neddylation | 0.979870 | 0.009 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.981082 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 0.983607 | 0.007 |
| R-HSA-15869 | Metabolism of nucleotides | 0.984245 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 0.988034 | 0.005 |
| R-HSA-1643685 | Disease | 0.988048 | 0.005 |
| R-HSA-416476 | G alpha (q) signalling events | 0.990034 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.991303 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.992077 | 0.003 |
| R-HSA-9658195 | Leishmania infection | 0.992457 | 0.003 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.992457 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.992469 | 0.003 |
| R-HSA-1483257 | Phospholipid metabolism | 0.994004 | 0.003 |
| R-HSA-1474244 | Extracellular matrix organization | 0.996680 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.996713 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997184 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999016 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999330 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999534 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999563 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999784 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999864 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999885 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999972 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999992 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.787 | 0.586 | 1 | 0.859 |
CDK7 |
0.787 | 0.594 | 1 | 0.844 |
P38G |
0.784 | 0.618 | 1 | 0.898 |
CDK18 |
0.784 | 0.572 | 1 | 0.878 |
HIPK2 |
0.784 | 0.545 | 1 | 0.853 |
CDK8 |
0.783 | 0.591 | 1 | 0.832 |
CDK3 |
0.781 | 0.527 | 1 | 0.895 |
JNK2 |
0.780 | 0.635 | 1 | 0.869 |
CDK17 |
0.780 | 0.585 | 1 | 0.895 |
CDK13 |
0.780 | 0.587 | 1 | 0.860 |
ERK1 |
0.780 | 0.610 | 1 | 0.859 |
CDK12 |
0.780 | 0.589 | 1 | 0.873 |
KIS |
0.780 | 0.517 | 1 | 0.820 |
P38D |
0.778 | 0.609 | 1 | 0.916 |
P38B |
0.776 | 0.612 | 1 | 0.847 |
CDK1 |
0.776 | 0.563 | 1 | 0.855 |
CDK5 |
0.775 | 0.558 | 1 | 0.820 |
CDK9 |
0.770 | 0.579 | 1 | 0.851 |
JNK3 |
0.768 | 0.611 | 1 | 0.854 |
DYRK2 |
0.768 | 0.524 | 1 | 0.779 |
P38A |
0.767 | 0.603 | 1 | 0.790 |
CDK16 |
0.766 | 0.542 | 1 | 0.891 |
CDK10 |
0.766 | 0.532 | 1 | 0.852 |
CDK14 |
0.764 | 0.566 | 1 | 0.837 |
CDK4 |
0.764 | 0.589 | 1 | 0.879 |
NLK |
0.763 | 0.628 | 1 | 0.596 |
ERK2 |
0.763 | 0.604 | 1 | 0.818 |
HIPK1 |
0.762 | 0.494 | 1 | 0.763 |
CLK3 |
0.762 | 0.317 | 1 | 0.572 |
DYRK4 |
0.762 | 0.524 | 1 | 0.865 |
HIPK4 |
0.761 | 0.365 | 1 | 0.588 |
CDK6 |
0.759 | 0.560 | 1 | 0.856 |
DYRK1B |
0.758 | 0.509 | 1 | 0.824 |
DYRK1A |
0.753 | 0.444 | 1 | 0.756 |
ERK5 |
0.752 | 0.364 | 1 | 0.527 |
HIPK3 |
0.751 | 0.487 | 1 | 0.735 |
JNK1 |
0.751 | 0.554 | 1 | 0.872 |
SRPK1 |
0.750 | 0.250 | -3 | 0.768 |
CDK2 |
0.748 | 0.447 | 1 | 0.742 |
CLK1 |
0.748 | 0.321 | -3 | 0.763 |
DYRK3 |
0.746 | 0.406 | 1 | 0.725 |
MAK |
0.746 | 0.385 | -2 | 0.810 |
CLK2 |
0.743 | 0.287 | -3 | 0.768 |
CLK4 |
0.743 | 0.301 | -3 | 0.785 |
SRPK2 |
0.739 | 0.199 | -3 | 0.699 |
ICK |
0.738 | 0.281 | -3 | 0.850 |
CDKL5 |
0.736 | 0.154 | -3 | 0.813 |
MTOR |
0.735 | 0.126 | 1 | 0.397 |
MOK |
0.733 | 0.355 | 1 | 0.664 |
CDC7 |
0.731 | 0.003 | 1 | 0.251 |
SRPK3 |
0.729 | 0.189 | -3 | 0.735 |
PRP4 |
0.728 | 0.347 | -3 | 0.793 |
COT |
0.728 | -0.086 | 2 | 0.683 |
ERK7 |
0.728 | 0.212 | 2 | 0.428 |
CDKL1 |
0.728 | 0.121 | -3 | 0.817 |
NEK6 |
0.726 | -0.004 | -2 | 0.867 |
NDR2 |
0.725 | 0.018 | -3 | 0.857 |
TGFBR2 |
0.724 | 0.049 | -2 | 0.850 |
AURC |
0.724 | 0.076 | -2 | 0.725 |
SMG1 |
0.724 | 0.223 | 1 | 0.271 |
GCN2 |
0.723 | -0.064 | 2 | 0.635 |
PRKD1 |
0.722 | 0.028 | -3 | 0.841 |
MOS |
0.721 | -0.026 | 1 | 0.298 |
PRKD2 |
0.720 | 0.043 | -3 | 0.794 |
PIM3 |
0.720 | -0.021 | -3 | 0.853 |
MST4 |
0.720 | 0.022 | 2 | 0.758 |
PRPK |
0.718 | -0.069 | -1 | 0.195 |
ATR |
0.718 | 0.006 | 1 | 0.286 |
RSK3 |
0.717 | 0.026 | -3 | 0.789 |
BMPR2 |
0.717 | -0.004 | -2 | 0.882 |
TBK1 |
0.716 | -0.093 | 1 | 0.183 |
RSK2 |
0.716 | 0.026 | -3 | 0.798 |
NEK7 |
0.715 | -0.055 | -3 | 0.838 |
NDR1 |
0.715 | -0.015 | -3 | 0.852 |
PAK6 |
0.715 | 0.062 | -2 | 0.752 |
IKKB |
0.713 | -0.076 | -2 | 0.718 |
DSTYK |
0.713 | -0.096 | 2 | 0.692 |
IKKE |
0.713 | -0.090 | 1 | 0.176 |
P90RSK |
0.713 | 0.017 | -3 | 0.799 |
CHAK2 |
0.712 | -0.054 | -1 | 0.173 |
PDHK4 |
0.712 | -0.095 | 1 | 0.289 |
CAMLCK |
0.711 | 0.054 | -2 | 0.874 |
LATS2 |
0.711 | -0.019 | -5 | 0.767 |
PIM1 |
0.710 | 0.009 | -3 | 0.802 |
CAMK1B |
0.710 | -0.034 | -3 | 0.864 |
PDHK1 |
0.710 | -0.069 | 1 | 0.261 |
ULK2 |
0.710 | -0.146 | 2 | 0.617 |
RAF1 |
0.710 | -0.146 | 1 | 0.219 |
NUAK2 |
0.709 | 0.000 | -3 | 0.854 |
WNK1 |
0.709 | -0.058 | -2 | 0.857 |
MNK2 |
0.709 | 0.003 | -2 | 0.824 |
NEK9 |
0.709 | -0.024 | 2 | 0.691 |
MAPKAPK3 |
0.709 | 0.004 | -3 | 0.801 |
AURB |
0.709 | 0.066 | -2 | 0.724 |
PKCD |
0.709 | -0.031 | 2 | 0.606 |
P70S6KB |
0.708 | 0.014 | -3 | 0.813 |
SKMLCK |
0.708 | -0.026 | -2 | 0.879 |
DAPK2 |
0.708 | 0.029 | -3 | 0.874 |
PKN3 |
0.708 | -0.050 | -3 | 0.838 |
NIK |
0.707 | -0.048 | -3 | 0.878 |
BMPR1B |
0.707 | 0.011 | 1 | 0.203 |
ATM |
0.707 | -0.025 | 1 | 0.249 |
MLK1 |
0.707 | -0.083 | 2 | 0.644 |
MAPKAPK2 |
0.707 | 0.006 | -3 | 0.763 |
PKACG |
0.706 | -0.004 | -2 | 0.773 |
MLK2 |
0.706 | -0.050 | 2 | 0.657 |
PHKG1 |
0.706 | -0.027 | -3 | 0.841 |
PAK3 |
0.705 | 0.000 | -2 | 0.814 |
BCKDK |
0.705 | -0.112 | -1 | 0.166 |
MLK3 |
0.705 | -0.038 | 2 | 0.575 |
RIPK3 |
0.705 | -0.076 | 3 | 0.713 |
WNK3 |
0.705 | -0.083 | 1 | 0.219 |
PRKD3 |
0.704 | 0.028 | -3 | 0.758 |
IKKA |
0.704 | -0.060 | -2 | 0.715 |
PAK1 |
0.704 | -0.005 | -2 | 0.825 |
PKG2 |
0.703 | 0.043 | -2 | 0.719 |
TGFBR1 |
0.703 | 0.009 | -2 | 0.835 |
MPSK1 |
0.703 | 0.055 | 1 | 0.299 |
PKN2 |
0.703 | -0.057 | -3 | 0.845 |
IRE1 |
0.703 | -0.087 | 1 | 0.219 |
AKT2 |
0.702 | 0.049 | -3 | 0.714 |
AURA |
0.702 | 0.057 | -2 | 0.715 |
ALK4 |
0.702 | 0.019 | -2 | 0.855 |
PKR |
0.702 | 0.012 | 1 | 0.240 |
PKACB |
0.702 | 0.037 | -2 | 0.733 |
GRK5 |
0.702 | -0.105 | -3 | 0.840 |
CAMK2G |
0.701 | -0.109 | 2 | 0.613 |
GRK1 |
0.700 | -0.050 | -2 | 0.774 |
PKCA |
0.700 | -0.030 | 2 | 0.568 |
PINK1 |
0.700 | 0.140 | 1 | 0.434 |
PKCB |
0.700 | -0.050 | 2 | 0.574 |
CAMK2D |
0.699 | -0.066 | -3 | 0.852 |
RSK4 |
0.699 | 0.008 | -3 | 0.771 |
GRK7 |
0.699 | -0.019 | 1 | 0.248 |
PAK5 |
0.698 | 0.041 | -2 | 0.703 |
DNAPK |
0.698 | -0.038 | 1 | 0.253 |
PKCZ |
0.698 | -0.065 | 2 | 0.617 |
AMPKA1 |
0.698 | -0.089 | -3 | 0.864 |
MNK1 |
0.698 | -0.023 | -2 | 0.828 |
ACVR2B |
0.698 | -0.007 | -2 | 0.832 |
ACVR2A |
0.698 | -0.007 | -2 | 0.825 |
VRK2 |
0.697 | 0.119 | 1 | 0.326 |
ULK1 |
0.697 | -0.161 | -3 | 0.796 |
LATS1 |
0.697 | -0.042 | -3 | 0.877 |
TSSK1 |
0.697 | -0.051 | -3 | 0.881 |
TTBK2 |
0.697 | -0.113 | 2 | 0.561 |
AMPKA2 |
0.696 | -0.059 | -3 | 0.838 |
PERK |
0.696 | -0.015 | -2 | 0.847 |
MELK |
0.696 | -0.039 | -3 | 0.823 |
MSK2 |
0.696 | -0.018 | -3 | 0.764 |
ALK2 |
0.696 | 0.013 | -2 | 0.842 |
SGK3 |
0.696 | 0.003 | -3 | 0.791 |
NUAK1 |
0.696 | -0.041 | -3 | 0.805 |
PKCG |
0.695 | -0.062 | 2 | 0.560 |
PAK4 |
0.695 | 0.040 | -2 | 0.722 |
PIM2 |
0.695 | 0.032 | -3 | 0.769 |
NEK2 |
0.695 | -0.077 | 2 | 0.665 |
TLK2 |
0.695 | -0.052 | 1 | 0.206 |
MASTL |
0.695 | -0.131 | -2 | 0.796 |
PRKX |
0.695 | 0.025 | -3 | 0.717 |
PAK2 |
0.695 | -0.004 | -2 | 0.811 |
RIPK1 |
0.695 | -0.129 | 1 | 0.204 |
IRE2 |
0.694 | -0.100 | 2 | 0.572 |
AKT1 |
0.694 | 0.042 | -3 | 0.737 |
NIM1 |
0.694 | -0.099 | 3 | 0.754 |
MSK1 |
0.693 | 0.013 | -3 | 0.772 |
DLK |
0.693 | -0.153 | 1 | 0.225 |
CAMK4 |
0.693 | -0.070 | -3 | 0.831 |
HUNK |
0.693 | -0.185 | 2 | 0.627 |
YSK4 |
0.693 | -0.085 | 1 | 0.196 |
CHAK1 |
0.692 | -0.091 | 2 | 0.621 |
GRK4 |
0.692 | -0.120 | -2 | 0.819 |
ANKRD3 |
0.692 | -0.150 | 1 | 0.233 |
GRK6 |
0.692 | -0.099 | 1 | 0.214 |
HRI |
0.692 | -0.053 | -2 | 0.859 |
BMPR1A |
0.691 | 0.009 | 1 | 0.192 |
PLK1 |
0.691 | -0.099 | -2 | 0.847 |
MYLK4 |
0.691 | 0.032 | -2 | 0.811 |
MLK4 |
0.691 | -0.100 | 2 | 0.554 |
MARK4 |
0.691 | -0.122 | 4 | 0.788 |
DCAMKL1 |
0.690 | -0.033 | -3 | 0.807 |
PKCH |
0.690 | -0.064 | 2 | 0.552 |
GSK3A |
0.690 | 0.112 | 4 | 0.415 |
FAM20C |
0.689 | -0.058 | 2 | 0.454 |
MEK1 |
0.689 | -0.053 | 2 | 0.651 |
MAPKAPK5 |
0.689 | -0.027 | -3 | 0.746 |
PLK4 |
0.688 | -0.101 | 2 | 0.467 |
PKACA |
0.688 | 0.033 | -2 | 0.683 |
CAMK2B |
0.688 | -0.075 | 2 | 0.597 |
PKCT |
0.687 | -0.051 | 2 | 0.567 |
BUB1 |
0.687 | 0.068 | -5 | 0.779 |
CAMK2A |
0.686 | -0.062 | 2 | 0.597 |
P70S6K |
0.686 | 0.018 | -3 | 0.734 |
TAO3 |
0.686 | -0.040 | 1 | 0.245 |
NEK5 |
0.686 | -0.057 | 1 | 0.222 |
CHK1 |
0.686 | -0.054 | -3 | 0.854 |
TSSK2 |
0.686 | -0.113 | -5 | 0.824 |
IRAK4 |
0.685 | -0.097 | 1 | 0.200 |
MST3 |
0.685 | -0.025 | 2 | 0.690 |
AKT3 |
0.685 | 0.041 | -3 | 0.660 |
WNK4 |
0.684 | -0.082 | -2 | 0.843 |
PKCI |
0.683 | -0.034 | 2 | 0.591 |
DRAK1 |
0.682 | -0.100 | 1 | 0.186 |
PLK3 |
0.682 | -0.102 | 2 | 0.571 |
QSK |
0.682 | -0.078 | 4 | 0.767 |
MEKK1 |
0.682 | -0.121 | 1 | 0.223 |
PHKG2 |
0.681 | -0.057 | -3 | 0.807 |
MEK5 |
0.680 | -0.099 | 2 | 0.652 |
MRCKB |
0.680 | 0.056 | -3 | 0.756 |
QIK |
0.680 | -0.117 | -3 | 0.846 |
LKB1 |
0.680 | -0.017 | -3 | 0.840 |
DCAMKL2 |
0.679 | -0.052 | -3 | 0.823 |
BRSK2 |
0.679 | -0.094 | -3 | 0.827 |
PKCE |
0.679 | -0.015 | 2 | 0.555 |
TAO2 |
0.679 | -0.022 | 2 | 0.672 |
ZAK |
0.678 | -0.151 | 1 | 0.195 |
SIK |
0.678 | -0.075 | -3 | 0.779 |
MEKK2 |
0.678 | -0.103 | 2 | 0.637 |
TLK1 |
0.678 | -0.103 | -2 | 0.846 |
LOK |
0.678 | 0.005 | -2 | 0.752 |
BRSK1 |
0.677 | -0.079 | -3 | 0.806 |
TTBK1 |
0.677 | -0.072 | 2 | 0.481 |
SNRK |
0.677 | -0.108 | 2 | 0.507 |
SGK1 |
0.676 | 0.038 | -3 | 0.646 |
NEK8 |
0.676 | -0.083 | 2 | 0.646 |
PKN1 |
0.676 | -0.019 | -3 | 0.751 |
HASPIN |
0.675 | -0.020 | -1 | 0.127 |
TNIK |
0.675 | -0.020 | 3 | 0.894 |
SMMLCK |
0.675 | -0.010 | -3 | 0.825 |
GSK3B |
0.674 | 0.016 | 4 | 0.408 |
HGK |
0.674 | -0.028 | 3 | 0.888 |
GAK |
0.674 | -0.030 | 1 | 0.289 |
MRCKA |
0.674 | 0.039 | -3 | 0.777 |
CAMK1G |
0.674 | -0.072 | -3 | 0.773 |
GRK2 |
0.674 | -0.086 | -2 | 0.709 |
PDK1 |
0.674 | -0.042 | 1 | 0.252 |
ROCK2 |
0.673 | 0.020 | -3 | 0.811 |
PBK |
0.673 | -0.015 | 1 | 0.274 |
SBK |
0.672 | 0.082 | -3 | 0.605 |
BRAF |
0.672 | -0.161 | -4 | 0.810 |
NEK4 |
0.672 | -0.081 | 1 | 0.196 |
PKG1 |
0.672 | 0.030 | -2 | 0.630 |
GCK |
0.671 | -0.059 | 1 | 0.213 |
MEKK3 |
0.671 | -0.166 | 1 | 0.215 |
CAMKK1 |
0.671 | -0.096 | -2 | 0.736 |
DAPK3 |
0.670 | -0.009 | -3 | 0.814 |
HPK1 |
0.670 | -0.026 | 1 | 0.208 |
NEK1 |
0.670 | -0.052 | 1 | 0.198 |
PASK |
0.670 | -0.085 | -3 | 0.868 |
MEKK6 |
0.669 | -0.090 | 1 | 0.223 |
CAMKK2 |
0.669 | -0.072 | -2 | 0.734 |
KHS1 |
0.669 | -0.027 | 1 | 0.205 |
TAK1 |
0.669 | -0.026 | 1 | 0.208 |
KHS2 |
0.669 | -0.009 | 1 | 0.215 |
CHK2 |
0.669 | 0.011 | -3 | 0.666 |
NEK11 |
0.669 | -0.130 | 1 | 0.228 |
CK1E |
0.669 | -0.050 | -3 | 0.526 |
MINK |
0.668 | -0.063 | 1 | 0.191 |
NEK3 |
0.668 | -0.028 | 1 | 0.219 |
CK2A2 |
0.668 | -0.067 | 1 | 0.200 |
MAP3K15 |
0.667 | -0.095 | 1 | 0.212 |
SLK |
0.667 | -0.049 | -2 | 0.696 |
IRAK1 |
0.667 | -0.171 | -1 | 0.199 |
MARK3 |
0.667 | -0.108 | 4 | 0.714 |
LRRK2 |
0.667 | -0.040 | 2 | 0.677 |
EEF2K |
0.667 | -0.047 | 3 | 0.851 |
BIKE |
0.666 | 0.016 | 1 | 0.276 |
MARK2 |
0.666 | -0.110 | 4 | 0.682 |
CAMK1D |
0.666 | -0.041 | -3 | 0.710 |
VRK1 |
0.666 | -0.052 | 2 | 0.651 |
AAK1 |
0.666 | 0.039 | 1 | 0.276 |
CRIK |
0.665 | 0.045 | -3 | 0.737 |
CK1G1 |
0.665 | -0.051 | -3 | 0.508 |
YSK1 |
0.665 | -0.054 | 2 | 0.680 |
SSTK |
0.664 | -0.108 | 4 | 0.770 |
MST2 |
0.664 | -0.106 | 1 | 0.207 |
DAPK1 |
0.663 | -0.005 | -3 | 0.796 |
CK1D |
0.663 | -0.022 | -3 | 0.472 |
MEK2 |
0.662 | -0.047 | 2 | 0.649 |
OSR1 |
0.662 | -0.021 | 2 | 0.659 |
ROCK1 |
0.661 | 0.017 | -3 | 0.775 |
GRK3 |
0.661 | -0.080 | -2 | 0.671 |
CAMK1A |
0.660 | -0.016 | -3 | 0.675 |
MARK1 |
0.659 | -0.131 | 4 | 0.739 |
DMPK1 |
0.658 | 0.020 | -3 | 0.777 |
RIPK2 |
0.658 | -0.112 | 1 | 0.183 |
STK33 |
0.658 | -0.112 | 2 | 0.460 |
TAO1 |
0.657 | -0.038 | 1 | 0.203 |
CK2A1 |
0.657 | -0.073 | 1 | 0.187 |
MYO3B |
0.656 | -0.022 | 2 | 0.678 |
CK1A2 |
0.656 | -0.042 | -3 | 0.472 |
MST1 |
0.655 | -0.127 | 1 | 0.192 |
PLK2 |
0.654 | -0.084 | -3 | 0.782 |
LIMK2_TYR |
0.652 | 0.117 | -3 | 0.892 |
PDHK3_TYR |
0.652 | 0.077 | 4 | 0.863 |
TTK |
0.651 | -0.058 | -2 | 0.867 |
MYO3A |
0.647 | -0.054 | 1 | 0.204 |
ASK1 |
0.646 | -0.100 | 1 | 0.213 |
MAP2K4_TYR |
0.646 | 0.050 | -1 | 0.202 |
TXK |
0.645 | 0.075 | 1 | 0.214 |
TESK1_TYR |
0.644 | -0.010 | 3 | 0.875 |
PKMYT1_TYR |
0.641 | 0.015 | 3 | 0.844 |
PDHK4_TYR |
0.641 | -0.016 | 2 | 0.683 |
NEK10_TYR |
0.640 | 0.009 | 1 | 0.217 |
MAP2K6_TYR |
0.638 | -0.046 | -1 | 0.179 |
ABL2 |
0.638 | -0.015 | -1 | 0.233 |
LCK |
0.637 | 0.018 | -1 | 0.260 |
MAP2K7_TYR |
0.637 | -0.076 | 2 | 0.668 |
TYRO3 |
0.637 | 0.032 | 3 | 0.799 |
STLK3 |
0.636 | -0.081 | 1 | 0.181 |
RET |
0.636 | -0.070 | 1 | 0.240 |
ABL1 |
0.636 | -0.013 | -1 | 0.238 |
EPHB4 |
0.636 | -0.018 | -1 | 0.255 |
YES1 |
0.636 | 0.016 | -1 | 0.269 |
BMX |
0.635 | 0.032 | -1 | 0.305 |
YANK3 |
0.635 | -0.066 | 2 | 0.298 |
MST1R |
0.635 | -0.024 | 3 | 0.800 |
ALPHAK3 |
0.634 | -0.122 | -1 | 0.142 |
HCK |
0.634 | 0.020 | -1 | 0.283 |
PINK1_TYR |
0.634 | -0.141 | 1 | 0.288 |
ITK |
0.634 | 0.013 | -1 | 0.287 |
TEC |
0.634 | 0.067 | -1 | 0.341 |
LIMK1_TYR |
0.634 | -0.045 | 2 | 0.673 |
BMPR2_TYR |
0.633 | -0.073 | -1 | 0.171 |
BLK |
0.633 | 0.003 | -1 | 0.255 |
PDHK1_TYR |
0.633 | -0.090 | -1 | 0.185 |
BTK |
0.632 | 0.084 | -1 | 0.347 |
ROS1 |
0.632 | -0.043 | 3 | 0.771 |
MERTK |
0.632 | 0.060 | 3 | 0.742 |
EPHA6 |
0.632 | -0.081 | -1 | 0.209 |
TNK2 |
0.632 | 0.014 | 3 | 0.735 |
CSF1R |
0.631 | -0.050 | 3 | 0.777 |
JAK1 |
0.631 | -0.033 | 1 | 0.209 |
JAK2 |
0.631 | -0.071 | 1 | 0.247 |
TYK2 |
0.630 | -0.120 | 1 | 0.229 |
WEE1_TYR |
0.628 | -0.020 | -1 | 0.222 |
TNK1 |
0.627 | -0.064 | 3 | 0.778 |
TNNI3K_TYR |
0.626 | -0.064 | 1 | 0.256 |
AXL |
0.626 | -0.001 | 3 | 0.743 |
SRMS |
0.626 | -0.029 | 1 | 0.206 |
TEK |
0.626 | 0.052 | 3 | 0.717 |
FGR |
0.625 | -0.102 | 1 | 0.226 |
PTK6 |
0.624 | -0.059 | -1 | 0.239 |
FER |
0.624 | -0.102 | 1 | 0.238 |
JAK3 |
0.624 | -0.153 | 1 | 0.238 |
EPHB3 |
0.623 | -0.050 | -1 | 0.264 |
EPHB2 |
0.623 | -0.052 | -1 | 0.259 |
EPHB1 |
0.622 | -0.053 | 1 | 0.207 |
FYN |
0.622 | -0.039 | -1 | 0.237 |
CK1A |
0.621 | -0.060 | -3 | 0.377 |
FGFR2 |
0.621 | -0.082 | 3 | 0.756 |
EPHA1 |
0.621 | 0.012 | 3 | 0.739 |
DDR1 |
0.620 | -0.124 | 4 | 0.778 |
FRK |
0.620 | 0.003 | -1 | 0.309 |
PTK2B |
0.619 | -0.010 | -1 | 0.287 |
FGFR1 |
0.619 | -0.071 | 3 | 0.735 |
EPHA4 |
0.619 | -0.072 | 2 | 0.569 |
KIT |
0.618 | -0.118 | 3 | 0.769 |
LTK |
0.617 | -0.044 | 3 | 0.715 |
FLT3 |
0.616 | -0.125 | 3 | 0.793 |
PDGFRB |
0.616 | -0.163 | 3 | 0.788 |
LYN |
0.616 | -0.026 | 3 | 0.698 |
MET |
0.616 | -0.102 | 3 | 0.765 |
KDR |
0.616 | -0.113 | 3 | 0.724 |
EPHA7 |
0.615 | -0.044 | 2 | 0.568 |
ALK |
0.615 | -0.075 | 3 | 0.701 |
INSRR |
0.615 | -0.158 | 3 | 0.724 |
PDGFRA |
0.614 | -0.131 | 3 | 0.792 |
SRC |
0.612 | -0.054 | -1 | 0.242 |
MUSK |
0.610 | -0.072 | 1 | 0.165 |
FGFR3 |
0.609 | -0.092 | 3 | 0.723 |
EPHA3 |
0.609 | -0.083 | 2 | 0.546 |
NTRK3 |
0.609 | -0.116 | -1 | 0.189 |
NTRK2 |
0.607 | -0.129 | 3 | 0.724 |
MATK |
0.607 | -0.102 | -1 | 0.157 |
EGFR |
0.607 | -0.097 | 1 | 0.174 |
NTRK1 |
0.606 | -0.163 | -1 | 0.199 |
EPHA8 |
0.606 | -0.088 | -1 | 0.220 |
EPHA5 |
0.605 | -0.088 | 2 | 0.541 |
ERBB2 |
0.605 | -0.131 | 1 | 0.206 |
INSR |
0.604 | -0.149 | 3 | 0.713 |
DDR2 |
0.604 | -0.079 | 3 | 0.702 |
FLT1 |
0.604 | -0.171 | -1 | 0.152 |
CK1G3 |
0.602 | -0.048 | -3 | 0.327 |
FGFR4 |
0.602 | -0.097 | -1 | 0.181 |
CSK |
0.602 | -0.113 | 2 | 0.578 |
FLT4 |
0.601 | -0.171 | 3 | 0.714 |
PTK2 |
0.599 | -0.103 | -1 | 0.146 |
SYK |
0.598 | -0.107 | -1 | 0.150 |
EPHA2 |
0.598 | -0.093 | -1 | 0.226 |
YANK2 |
0.597 | -0.084 | 2 | 0.299 |
ZAP70 |
0.594 | -0.076 | -1 | 0.122 |
FES |
0.591 | -0.068 | -1 | 0.259 |
ERBB4 |
0.589 | -0.097 | 1 | 0.176 |
IGF1R |
0.588 | -0.151 | 3 | 0.644 |
CK1G2 |
0.576 | -0.078 | -3 | 0.423 |