Motif 597 (n=123)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S981 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A1X283 | SH3PXD2B | S500 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| O00180 | KCNK1 | S303 | ochoa | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1) | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086, PubMed:8605869, PubMed:8978667). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}. |
| O00193 | SMAP | S25 | ochoa | Small acidic protein | None |
| O14595 | CTDSP2 | S55 | ochoa | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2) | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
| O14595 | CTDSP2 | S56 | ochoa | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2) | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
| O14654 | IRS4 | S251 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14827 | RASGRF2 | S794 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O43290 | SART1 | S112 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43294 | TGFB1I1 | S82 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43432 | EIF4G3 | S1157 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O60701 | UGDH | S350 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O76031 | CLPX | S611 | ochoa | ATP-dependent clpX-like chaperone, mitochondrial (EC 3.6.4.10) (ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial) (Caseinolytic mitochondrial matrix peptidase chaperone subunit X) | ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:11923310, PubMed:22710082, PubMed:28874591). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (PubMed:22841477). {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:28874591}. |
| O76061 | STC2 | S251 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
| O95759 | TBC1D8 | S1037 | ochoa | TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) | May act as a GTPase-activating protein for Rab family protein(s). |
| O95936 | EOMES | S651 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| P04279 | SEMG1 | S292 | ochoa | Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein] | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}. |
| P11362 | FGFR1 | S452 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P13796 | LCP1 | S111 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P23497 | SP100 | S453 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P27448 | MARK3 | S490 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P29375 | KDM5A | S1367 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P29375 | KDM5A | S1368 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P30304 | CDC25A | S267 | ochoa | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31146 | CORO1A | S427 | ochoa | Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO) | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}. |
| P32418 | SLC8A1 | S392 | ochoa | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity). {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}. |
| P35269 | GTF2F1 | S399 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35609 | ACTN2 | S596 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P40818 | USP8 | S719 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P40925 | MDH1 | S242 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P46100 | ATRX | S1013 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46940 | IQGAP1 | S481 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49790 | NUP153 | S938 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P54105 | CLNS1A | S198 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P54296 | MYOM2 | S1273 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54296 | MYOM2 | S1274 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P57103 | SLC8A3 | S382 | ochoa | Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}. |
| P78559 | MAP1A | S527 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01658 | DR1 | S106 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q09666 | AHNAK | S110 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1619 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12906 | ILF3 | S20 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13342 | SP140 | S185 | ochoa | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}. |
| Q13554 | CAMK2B | S395 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q14126 | DSG2 | S700 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14738 | PPP2R5D | S89 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14934 | NFATC4 | S335 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14978 | NOLC1 | S128 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S129 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S221 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S265 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S266 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S267 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14D04 | VEPH1 | T381 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15021 | NCAPD2 | S1371 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15172 | PPP2R5A | S42 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15424 | SAFB | S197 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16537 | PPP2R5E | S34 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q16659 | MAPK6 | Y453 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q16891 | IMMT | S584 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q29RF7 | PDS5A | S1187 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q5T0W9 | FAM83B | S803 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T1M5 | FKBP15 | S1093 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5VTQ0 | TTC39B | S126 | ochoa | Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) | Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}. |
| Q5VV67 | PPRC1 | S482 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q6PJG6 | BRAT1 | S574 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6PL18 | ATAD2 | S1277 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UWH4 | GASK1B | S200 | ochoa | Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B) | None |
| Q6UXM1 | LRIG3 | S1073 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}. |
| Q6YP21 | KYAT3 | S191 | ochoa | Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). {ECO:0000250|UniProtKB:Q71RI9}. |
| Q7Z4S6 | KIF21A | S854 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q8NEV8 | EXPH5 | S912 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NG31 | KNL1 | S629 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TAA9 | VANGL1 | S339 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TF17 | SH3TC2 | S30 | ochoa | SH3 domain and tetratricopeptide repeat-containing protein 2 | None |
| Q8WWM7 | ATXN2L | Y277 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWY3 | PRPF31 | S451 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92539 | LPIN2 | S135 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q96AQ6 | PBXIP1 | S147 | ochoa|psp | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96D71 | REPS1 | S273 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96D71 | REPS1 | S274 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96GY0 | ZC2HC1A | S279 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96PN7 | TRERF1 | S619 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96QR8 | PURB | S101 | ochoa | Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) | Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250|UniProtKB:O35295, ECO:0000250|UniProtKB:Q68A21, ECO:0000269|PubMed:1448097}. |
| Q99590 | SCAF11 | S402 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BQI5 | SGIP1 | S170 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BRQ6 | CHCHD6 | S75 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BXK5 | BCL2L13 | S303 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BZ72 | PITPNM2 | S400 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZV2 | SLC19A3 | S212 | ochoa | Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) | Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177). {ECO:0000269|PubMed:11731220, ECO:0000269|PubMed:33008889, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964, ECO:0000269|PubMed:36456177}. |
| Q9C0K0 | BCL11B | S789 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H165 | BCL11A | S735 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9HBM0 | VEZT | S678 | ochoa | Vezatin | Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}. |
| Q9NPI6 | DCP1A | S523 | ochoa|psp | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NRL2 | BAZ1A | S1280 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9P2B4 | CTTNBP2NL | Y345 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9ULH0 | KIDINS220 | S1741 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S461 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UNA1 | ARHGAP26 | S589 | ochoa | Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}. |
| Q9UQM7 | CAMK2A | S331 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2K1 | ZBTB1 | S305 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y3T9 | NOC2L | S673 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4I1 | MYO5A | S1119 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
| Q9Y6R1 | SLC4A4 | S256 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| P26639 | TARS1 | S282 | Sugiyama | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P25205 | MCM3 | Y705 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P51813 | BMX | S187 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P13797 | PLS3 | S114 | Sugiyama | Plastin-3 (T-fimbrin) (T-plastin) | Actin-bundling protein. |
| P39019 | RPS19 | S98 | Sugiyama | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q14204 | DYNC1H1 | S4163 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| O60814 | H2BC12 | Y84 | EPSD | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P06899 | H2BC11 | Y84 | EPSD | Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P23527 | H2BC17 | Y84 | EPSD | Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P33778 | H2BC3 | Y84 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P58876 | H2BC5 | Y84 | EPSD | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | Y84 | EPSD | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16778 | H2BC21 | Y84 | EPSD | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q5QNW6 | H2BC18 | Y84 | EPSD | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DN03 | H2BC20P | Y84 | EPSD | Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DRA6 | H2BC19P | Y84 | EPSD | Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93079 | H2BC9 | Y84 | EPSD | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99877 | H2BC15 | Y84 | EPSD | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | Y84 | EPSD | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-171306 | Packaging Of Telomere Ends | 5.662137e-15 | 14.247 |
| R-HSA-5334118 | DNA methylation | 1.076916e-14 | 13.968 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 7.327472e-15 | 14.135 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 9.325873e-15 | 14.030 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 5.662137e-15 | 14.247 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.998401e-15 | 14.699 |
| R-HSA-774815 | Nucleosome assembly | 2.964295e-14 | 13.528 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.964295e-14 | 13.528 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.609024e-14 | 13.584 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.441691e-14 | 13.463 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.884182e-14 | 13.230 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.884182e-14 | 13.230 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 9.814372e-14 | 13.008 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.254552e-13 | 12.902 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.254552e-13 | 12.902 |
| R-HSA-73927 | Depurination | 1.595390e-13 | 12.797 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.203793e-13 | 12.657 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.540190e-13 | 12.595 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.180789e-13 | 12.497 |
| R-HSA-3214847 | HATs acetylate histones | 4.509726e-13 | 12.346 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.917178e-13 | 12.308 |
| R-HSA-73928 | Depyrimidination | 4.917178e-13 | 12.308 |
| R-HSA-9710421 | Defective pyroptosis | 6.072920e-13 | 12.217 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.116107e-12 | 11.952 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.642908e-12 | 11.784 |
| R-HSA-912446 | Meiotic recombination | 2.858602e-12 | 11.544 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.416156e-12 | 11.466 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.456679e-12 | 11.461 |
| R-HSA-1221632 | Meiotic synapsis | 4.069856e-12 | 11.390 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.069856e-12 | 11.390 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.834355e-12 | 11.316 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 9.361401e-12 | 11.029 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.097133e-11 | 10.960 |
| R-HSA-977225 | Amyloid fiber formation | 1.169509e-11 | 10.932 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.282674e-11 | 10.892 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.317813e-11 | 10.880 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.282674e-11 | 10.892 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.740841e-11 | 10.759 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.740841e-11 | 10.759 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.113487e-11 | 10.507 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.122880e-11 | 10.505 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.595513e-11 | 10.444 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.131595e-11 | 10.384 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.424627e-11 | 10.266 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.424627e-11 | 10.266 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.198808e-11 | 10.208 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.198808e-11 | 10.208 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.145107e-11 | 10.211 |
| R-HSA-4839726 | Chromatin organization | 7.367951e-11 | 10.133 |
| R-HSA-68875 | Mitotic Prophase | 8.802226e-11 | 10.055 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 8.475443e-11 | 10.072 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.153878e-11 | 10.038 |
| R-HSA-68886 | M Phase | 9.568535e-11 | 10.019 |
| R-HSA-73886 | Chromosome Maintenance | 9.630652e-11 | 10.016 |
| R-HSA-157579 | Telomere Maintenance | 1.049495e-10 | 9.979 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.150422e-10 | 9.939 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.167912e-10 | 9.933 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.177298e-10 | 9.929 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.504731e-10 | 9.823 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.911818e-10 | 9.719 |
| R-HSA-69481 | G2/M Checkpoints | 1.772841e-10 | 9.751 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.150344e-10 | 9.667 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.415274e-10 | 9.617 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.034771e-10 | 9.518 |
| R-HSA-1500620 | Meiosis | 3.395103e-10 | 9.469 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.265102e-10 | 9.486 |
| R-HSA-211000 | Gene Silencing by RNA | 3.121496e-10 | 9.506 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.761730e-10 | 9.425 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.346029e-10 | 9.197 |
| R-HSA-73884 | Base Excision Repair | 6.486510e-10 | 9.188 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.196220e-10 | 9.143 |
| R-HSA-8852135 | Protein ubiquitination | 1.863510e-09 | 8.730 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.529372e-09 | 8.597 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.529372e-09 | 8.597 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.562946e-09 | 8.591 |
| R-HSA-9609690 | HCMV Early Events | 2.651526e-09 | 8.577 |
| R-HSA-1474165 | Reproduction | 3.028542e-09 | 8.519 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.306958e-09 | 8.481 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.306958e-09 | 8.481 |
| R-HSA-1640170 | Cell Cycle | 3.911966e-09 | 8.408 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.068306e-09 | 8.295 |
| R-HSA-195721 | Signaling by WNT | 6.900593e-09 | 8.161 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.081464e-09 | 8.150 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.678371e-09 | 8.115 |
| R-HSA-5693538 | Homology Directed Repair | 1.230233e-08 | 7.910 |
| R-HSA-69306 | DNA Replication | 1.705957e-08 | 7.768 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.817340e-08 | 7.741 |
| R-HSA-9610379 | HCMV Late Events | 2.191755e-08 | 7.659 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.227015e-08 | 7.652 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.227015e-08 | 7.652 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.227015e-08 | 7.652 |
| R-HSA-9609646 | HCMV Infection | 4.449082e-08 | 7.352 |
| R-HSA-5688426 | Deubiquitination | 5.562430e-08 | 7.255 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.813258e-08 | 7.236 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.632115e-07 | 6.787 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.980522e-07 | 6.703 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.816796e-07 | 6.317 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.067394e-07 | 6.295 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.067394e-07 | 6.295 |
| R-HSA-418990 | Adherens junctions interactions | 5.744528e-07 | 6.241 |
| R-HSA-1500931 | Cell-Cell communication | 6.102091e-07 | 6.215 |
| R-HSA-2559583 | Cellular Senescence | 7.168268e-07 | 6.145 |
| R-HSA-5673000 | RAF activation | 1.185385e-06 | 5.926 |
| R-HSA-8939211 | ESR-mediated signaling | 1.270627e-06 | 5.896 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.796862e-06 | 5.745 |
| R-HSA-421270 | Cell-cell junction organization | 2.185475e-06 | 5.660 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.383677e-06 | 5.269 |
| R-HSA-446728 | Cell junction organization | 5.696544e-06 | 5.244 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.970491e-06 | 5.047 |
| R-HSA-157118 | Signaling by NOTCH | 9.007923e-06 | 5.045 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.275283e-05 | 4.643 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.329385e-05 | 4.364 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.284596e-05 | 4.277 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.531162e-05 | 4.185 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 7.361720e-05 | 4.133 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.116025e-04 | 3.674 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.116025e-04 | 3.674 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.116025e-04 | 3.674 |
| R-HSA-4839744 | Signaling by APC mutants | 2.116025e-04 | 3.674 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.587466e-04 | 3.587 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.587466e-04 | 3.587 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.587466e-04 | 3.587 |
| R-HSA-73894 | DNA Repair | 2.614363e-04 | 3.583 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.976099e-04 | 3.526 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 3.121950e-04 | 3.506 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 3.121950e-04 | 3.506 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 3.121950e-04 | 3.506 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 3.121950e-04 | 3.506 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 3.121950e-04 | 3.506 |
| R-HSA-1299308 | Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | 4.988311e-04 | 3.302 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 5.137209e-04 | 3.289 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.973647e-04 | 3.157 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 6.973647e-04 | 3.157 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 7.753475e-04 | 3.111 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 8.204418e-04 | 3.086 |
| R-HSA-432142 | Platelet sensitization by LDL | 8.902866e-04 | 3.050 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.975093e-04 | 3.001 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.975093e-04 | 3.001 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.975093e-04 | 3.001 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.975093e-04 | 3.001 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.024602e-03 | 2.989 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.024602e-03 | 2.989 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.130087e-03 | 2.947 |
| R-HSA-5576891 | Cardiac conduction | 1.265598e-03 | 2.898 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.317178e-03 | 2.880 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.407123e-03 | 2.852 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.407123e-03 | 2.852 |
| R-HSA-2262752 | Cellular responses to stress | 1.651332e-03 | 2.782 |
| R-HSA-68877 | Mitotic Prometaphase | 1.695836e-03 | 2.771 |
| R-HSA-5578775 | Ion homeostasis | 1.851148e-03 | 2.733 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 1.953949e-03 | 2.709 |
| R-HSA-9620244 | Long-term potentiation | 2.080821e-03 | 2.682 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.112804e-03 | 2.675 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.481141e-03 | 2.605 |
| R-HSA-418346 | Platelet homeostasis | 2.744572e-03 | 2.562 |
| R-HSA-397014 | Muscle contraction | 2.797291e-03 | 2.553 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.965567e-03 | 2.528 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.053363e-03 | 2.515 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.638615e-03 | 2.439 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.680244e-03 | 2.434 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.955539e-03 | 2.403 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 5.026626e-03 | 2.299 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.469088e-03 | 2.350 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 5.026626e-03 | 2.299 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.137163e-03 | 2.289 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.584510e-03 | 2.253 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.488447e-03 | 2.188 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 6.622850e-03 | 2.179 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 6.622850e-03 | 2.179 |
| R-HSA-425561 | Sodium/Calcium exchangers | 6.622850e-03 | 2.179 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.915343e-03 | 2.160 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 7.404772e-03 | 2.130 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 7.404772e-03 | 2.130 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.709912e-03 | 2.113 |
| R-HSA-162582 | Signal Transduction | 8.415337e-03 | 2.075 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.040715e-02 | 1.983 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.061651e-02 | 1.974 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.147172e-02 | 1.940 |
| R-HSA-1280218 | Adaptive Immune System | 1.156080e-02 | 1.937 |
| R-HSA-68882 | Mitotic Anaphase | 1.224089e-02 | 1.912 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.247557e-02 | 1.904 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.335142e-02 | 1.874 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.373746e-02 | 1.862 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 1.493706e-02 | 1.826 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.493706e-02 | 1.826 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.589517e-02 | 1.799 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.589517e-02 | 1.799 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.589517e-02 | 1.799 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.589517e-02 | 1.799 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.589517e-02 | 1.799 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.618013e-02 | 1.791 |
| R-HSA-913531 | Interferon Signaling | 1.650028e-02 | 1.783 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.746589e-02 | 1.758 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.746589e-02 | 1.758 |
| R-HSA-373753 | Nephrin family interactions | 1.746589e-02 | 1.758 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.843229e-02 | 1.734 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.058635e-02 | 1.686 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.133384e-02 | 1.671 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.157194e-02 | 1.666 |
| R-HSA-9824446 | Viral Infection Pathways | 2.157753e-02 | 1.666 |
| R-HSA-1266738 | Developmental Biology | 2.336800e-02 | 1.631 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.374849e-02 | 1.624 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.450932e-02 | 1.611 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.603587e-02 | 1.584 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.529250e-02 | 1.597 |
| R-HSA-8949613 | Cristae formation | 2.920121e-02 | 1.535 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.083864e-02 | 1.511 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.596189e-02 | 1.444 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.603587e-02 | 1.584 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.603587e-02 | 1.584 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.251166e-02 | 1.488 |
| R-HSA-1538133 | G0 and Early G1 | 3.773779e-02 | 1.423 |
| R-HSA-1643685 | Disease | 2.680085e-02 | 1.572 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.773779e-02 | 1.423 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.712685e-02 | 1.567 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 3.926904e-02 | 1.406 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.954668e-02 | 1.403 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.954668e-02 | 1.403 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.954668e-02 | 1.403 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.954668e-02 | 1.403 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.516511e-02 | 1.345 |
| R-HSA-69242 | S Phase | 4.523099e-02 | 1.345 |
| R-HSA-111933 | Calmodulin induced events | 4.709979e-02 | 1.327 |
| R-HSA-111997 | CaM pathway | 4.709979e-02 | 1.327 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.906438e-02 | 1.309 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.030387e-02 | 1.298 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 5.454473e-02 | 1.263 |
| R-HSA-877300 | Interferon gamma signaling | 5.476102e-02 | 1.262 |
| R-HSA-190236 | Signaling by FGFR | 5.790483e-02 | 1.237 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.931577e-02 | 1.227 |
| R-HSA-111996 | Ca-dependent events | 6.144774e-02 | 1.211 |
| R-HSA-111885 | Opioid Signalling | 6.574767e-02 | 1.182 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.574767e-02 | 1.182 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.799706e-02 | 1.168 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.799706e-02 | 1.168 |
| R-HSA-75153 | Apoptotic execution phase | 7.022952e-02 | 1.153 |
| R-HSA-425410 | Metal ion SLC transporters | 7.476534e-02 | 1.126 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 7.700751e-02 | 1.113 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 7.700751e-02 | 1.113 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 7.700751e-02 | 1.113 |
| R-HSA-597592 | Post-translational protein modification | 7.803288e-02 | 1.108 |
| R-HSA-109704 | PI3K Cascade | 7.939229e-02 | 1.100 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 8.437679e-02 | 1.074 |
| R-HSA-170984 | ARMS-mediated activation | 9.168768e-02 | 1.038 |
| R-HSA-9700645 | ALK mutants bind TKIs | 9.168768e-02 | 1.038 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 9.894064e-02 | 1.005 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.132746e-01 | 0.946 |
| R-HSA-5654736 | Signaling by FGFR1 | 9.378050e-02 | 1.028 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.273823e-01 | 0.895 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.397140e-01 | 0.855 |
| R-HSA-176974 | Unwinding of DNA | 9.168768e-02 | 1.038 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.132746e-01 | 0.946 |
| R-HSA-202670 | ERKs are inactivated | 1.132746e-01 | 0.946 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.012366e-01 | 0.995 |
| R-HSA-191859 | snRNP Assembly | 1.012366e-01 | 0.995 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.062961e-01 | 0.973 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.271706e-01 | 0.896 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.624754e-02 | 1.017 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.203565e-01 | 0.920 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.623011e-01 | 0.790 |
| R-HSA-1483226 | Synthesis of PI | 1.061361e-01 | 0.974 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.549330e-01 | 0.810 |
| R-HSA-169893 | Prolonged ERK activation events | 1.481273e-01 | 0.829 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 9.168768e-02 | 1.038 |
| R-HSA-425381 | Bicarbonate transporters | 1.061361e-01 | 0.974 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.412673e-01 | 0.850 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.481273e-01 | 0.829 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.385775e-01 | 0.858 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.165977e-01 | 0.933 |
| R-HSA-983189 | Kinesins | 1.037578e-01 | 0.984 |
| R-HSA-196819 | Vitamin B1 (thiamin) metabolism | 1.061361e-01 | 0.974 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.343524e-01 | 0.872 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.379446e-01 | 0.860 |
| R-HSA-69206 | G1/S Transition | 1.031683e-01 | 0.986 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.886361e-02 | 1.051 |
| R-HSA-9758941 | Gastrulation | 1.508696e-01 | 0.821 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.412673e-01 | 0.850 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.616847e-01 | 0.791 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.169054e-01 | 0.932 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.298448e-01 | 0.887 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.343524e-01 | 0.872 |
| R-HSA-193648 | NRAGE signals death through JNK | 9.378050e-02 | 1.028 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.452559e-01 | 0.838 |
| R-HSA-3371571 | HSF1-dependent transactivation | 8.173869e-02 | 1.088 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.434052e-01 | 0.843 |
| R-HSA-112399 | IRS-mediated signalling | 9.624754e-02 | 1.017 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.352322e-01 | 0.869 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.437679e-02 | 1.074 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.437679e-02 | 1.074 |
| R-HSA-9833482 | PKR-mediated signaling | 1.572484e-01 | 0.803 |
| R-HSA-112043 | PLC beta mediated events | 1.062961e-01 | 0.973 |
| R-HSA-112040 | G-protein mediated events | 1.218631e-01 | 0.914 |
| R-HSA-5663205 | Infectious disease | 1.405821e-01 | 0.852 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.375529e-01 | 0.862 |
| R-HSA-3371556 | Cellular response to heat stress | 9.511190e-02 | 1.022 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.516800e-01 | 0.819 |
| R-HSA-392499 | Metabolism of proteins | 1.601810e-01 | 0.795 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.140099e-01 | 0.943 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.379446e-01 | 0.860 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.549330e-01 | 0.810 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.616847e-01 | 0.791 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.140099e-01 | 0.943 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.166127e-01 | 0.933 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.099899e-01 | 0.959 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.461526e-01 | 0.835 |
| R-HSA-168256 | Immune System | 1.183459e-01 | 0.927 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.683828e-01 | 0.774 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.713316e-01 | 0.766 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.750279e-01 | 0.757 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.750279e-01 | 0.757 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.770231e-01 | 0.752 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.798801e-01 | 0.745 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.816203e-01 | 0.741 |
| R-HSA-445144 | Signal transduction by L1 | 1.816203e-01 | 0.741 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.816203e-01 | 0.741 |
| R-HSA-198753 | ERK/MAPK targets | 1.881604e-01 | 0.725 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 1.881604e-01 | 0.725 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.913762e-01 | 0.718 |
| R-HSA-212436 | Generic Transcription Pathway | 1.918221e-01 | 0.717 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.942659e-01 | 0.712 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.946486e-01 | 0.711 |
| R-HSA-74752 | Signaling by Insulin receptor | 1.971612e-01 | 0.705 |
| R-HSA-112316 | Neuronal System | 1.995042e-01 | 0.700 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.010854e-01 | 0.697 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.029678e-01 | 0.693 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.074712e-01 | 0.683 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.074712e-01 | 0.683 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.117136e-01 | 0.674 |
| R-HSA-1296071 | Potassium Channels | 2.117136e-01 | 0.674 |
| R-HSA-168255 | Influenza Infection | 2.124068e-01 | 0.673 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.138063e-01 | 0.670 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.138063e-01 | 0.670 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.190927e-01 | 0.659 |
| R-HSA-3214842 | HDMs demethylate histones | 2.200911e-01 | 0.657 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.204965e-01 | 0.657 |
| R-HSA-70171 | Glycolysis | 2.234312e-01 | 0.651 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.263261e-01 | 0.645 |
| R-HSA-69275 | G2/M Transition | 2.270085e-01 | 0.644 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.312165e-01 | 0.636 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.325116e-01 | 0.634 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.325116e-01 | 0.634 |
| R-HSA-75109 | Triglyceride biosynthesis | 2.325116e-01 | 0.634 |
| R-HSA-1483213 | Synthesis of PE | 2.325116e-01 | 0.634 |
| R-HSA-264876 | Insulin processing | 2.325116e-01 | 0.634 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.325116e-01 | 0.634 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.386481e-01 | 0.622 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.386481e-01 | 0.622 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.386481e-01 | 0.622 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.386481e-01 | 0.622 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.439252e-01 | 0.613 |
| R-HSA-72086 | mRNA Capping | 2.447358e-01 | 0.611 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.447358e-01 | 0.611 |
| R-HSA-180024 | DARPP-32 events | 2.447358e-01 | 0.611 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.447358e-01 | 0.611 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.507753e-01 | 0.601 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.507753e-01 | 0.601 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.507753e-01 | 0.601 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.567457e-01 | 0.590 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.567668e-01 | 0.590 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.567668e-01 | 0.590 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.617854e-01 | 0.582 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.617854e-01 | 0.582 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.622256e-01 | 0.581 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.627108e-01 | 0.581 |
| R-HSA-69190 | DNA strand elongation | 2.627108e-01 | 0.581 |
| R-HSA-72172 | mRNA Splicing | 2.675012e-01 | 0.573 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.686076e-01 | 0.571 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.686076e-01 | 0.571 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.686076e-01 | 0.571 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.686076e-01 | 0.571 |
| R-HSA-9733709 | Cardiogenesis | 2.686076e-01 | 0.571 |
| R-HSA-390522 | Striated Muscle Contraction | 2.744576e-01 | 0.562 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.744576e-01 | 0.562 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.744576e-01 | 0.562 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.802612e-01 | 0.552 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.802612e-01 | 0.552 |
| R-HSA-70326 | Glucose metabolism | 2.824912e-01 | 0.549 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.854469e-01 | 0.544 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.860188e-01 | 0.544 |
| R-HSA-187687 | Signalling to ERKs | 2.860188e-01 | 0.544 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.860188e-01 | 0.544 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.869890e-01 | 0.542 |
| R-HSA-199991 | Membrane Trafficking | 2.898627e-01 | 0.538 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 2.917306e-01 | 0.535 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.917306e-01 | 0.535 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.958470e-01 | 0.529 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.973971e-01 | 0.527 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.978895e-01 | 0.526 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.002051e-01 | 0.523 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.030185e-01 | 0.519 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.030185e-01 | 0.519 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.030185e-01 | 0.519 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.085954e-01 | 0.511 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.085954e-01 | 0.511 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.085954e-01 | 0.511 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.141280e-01 | 0.503 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.141280e-01 | 0.503 |
| R-HSA-167169 | HIV Transcription Elongation | 3.141280e-01 | 0.503 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.141280e-01 | 0.503 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.141280e-01 | 0.503 |
| R-HSA-9646399 | Aggrephagy | 3.141280e-01 | 0.503 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.141280e-01 | 0.503 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.141280e-01 | 0.503 |
| R-HSA-71240 | Tryptophan catabolism | 3.141280e-01 | 0.503 |
| R-HSA-109582 | Hemostasis | 3.176510e-01 | 0.498 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.178497e-01 | 0.498 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.196166e-01 | 0.495 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.196166e-01 | 0.495 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.250617e-01 | 0.488 |
| R-HSA-167161 | HIV Transcription Initiation | 3.250617e-01 | 0.488 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.250617e-01 | 0.488 |
| R-HSA-74160 | Gene expression (Transcription) | 3.283820e-01 | 0.484 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.304635e-01 | 0.481 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.304635e-01 | 0.481 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.358224e-01 | 0.474 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.358224e-01 | 0.474 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.411388e-01 | 0.467 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.464129e-01 | 0.460 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.464129e-01 | 0.460 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.464129e-01 | 0.460 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.464129e-01 | 0.460 |
| R-HSA-163685 | Integration of energy metabolism | 3.470172e-01 | 0.460 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.516452e-01 | 0.454 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.516452e-01 | 0.454 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.516452e-01 | 0.454 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.556925e-01 | 0.449 |
| R-HSA-1483191 | Synthesis of PC | 3.568358e-01 | 0.448 |
| R-HSA-5620924 | Intraflagellar transport | 3.619853e-01 | 0.441 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.671964e-01 | 0.435 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.721617e-01 | 0.429 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.821771e-01 | 0.418 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.821771e-01 | 0.418 |
| R-HSA-166520 | Signaling by NTRKs | 3.843027e-01 | 0.415 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.871252e-01 | 0.412 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.899617e-01 | 0.409 |
| R-HSA-72649 | Translation initiation complex formation | 3.920340e-01 | 0.407 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.920340e-01 | 0.407 |
| R-HSA-156588 | Glucuronidation | 3.920340e-01 | 0.407 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.955980e-01 | 0.403 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.969037e-01 | 0.401 |
| R-HSA-73887 | Death Receptor Signaling | 4.012107e-01 | 0.397 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.017347e-01 | 0.396 |
| R-HSA-177929 | Signaling by EGFR | 4.017347e-01 | 0.396 |
| R-HSA-162587 | HIV Life Cycle | 4.095843e-01 | 0.388 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.112819e-01 | 0.386 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.159987e-01 | 0.381 |
| R-HSA-8979227 | Triglyceride metabolism | 4.159987e-01 | 0.381 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.206779e-01 | 0.376 |
| R-HSA-379724 | tRNA Aminoacylation | 4.206779e-01 | 0.376 |
| R-HSA-109581 | Apoptosis | 4.234136e-01 | 0.373 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.253199e-01 | 0.371 |
| R-HSA-450294 | MAP kinase activation | 4.253199e-01 | 0.371 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.299251e-01 | 0.367 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.299251e-01 | 0.367 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.299251e-01 | 0.367 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.344936e-01 | 0.362 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.344936e-01 | 0.362 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.344936e-01 | 0.362 |
| R-HSA-5619102 | SLC transporter disorders | 4.370766e-01 | 0.359 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.479823e-01 | 0.349 |
| R-HSA-167172 | Transcription of the HIV genome | 4.567969e-01 | 0.340 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.567969e-01 | 0.340 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.612251e-01 | 0.336 |
| R-HSA-1483257 | Phospholipid metabolism | 4.635049e-01 | 0.334 |
| R-HSA-448424 | Interleukin-17 signaling | 4.654718e-01 | 0.332 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.697576e-01 | 0.328 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.740092e-01 | 0.324 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.740092e-01 | 0.324 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.782271e-01 | 0.320 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.782271e-01 | 0.320 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.782271e-01 | 0.320 |
| R-HSA-4086398 | Ca2+ pathway | 4.782271e-01 | 0.320 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.824113e-01 | 0.317 |
| R-HSA-380287 | Centrosome maturation | 4.865623e-01 | 0.313 |
| R-HSA-983712 | Ion channel transport | 4.975715e-01 | 0.303 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.981953e-01 | 0.303 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.988181e-01 | 0.302 |
| R-HSA-5617833 | Cilium Assembly | 5.001083e-01 | 0.301 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.068269e-01 | 0.295 |
| R-HSA-6806834 | Signaling by MET | 5.068269e-01 | 0.295 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.107836e-01 | 0.292 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.147087e-01 | 0.288 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.224655e-01 | 0.282 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 5.323366e-01 | 0.274 |
| R-HSA-8953854 | Metabolism of RNA | 5.323906e-01 | 0.274 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.338706e-01 | 0.273 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.338706e-01 | 0.273 |
| R-HSA-5357801 | Programmed Cell Death | 5.395726e-01 | 0.268 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.413235e-01 | 0.267 |
| R-HSA-156902 | Peptide chain elongation | 5.413235e-01 | 0.267 |
| R-HSA-9663891 | Selective autophagy | 5.413235e-01 | 0.267 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.486580e-01 | 0.261 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.522816e-01 | 0.258 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.558762e-01 | 0.255 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.594422e-01 | 0.252 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.664893e-01 | 0.247 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.699707e-01 | 0.244 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.734244e-01 | 0.242 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.734244e-01 | 0.242 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.768506e-01 | 0.239 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.836213e-01 | 0.234 |
| R-HSA-422356 | Regulation of insulin secretion | 5.836213e-01 | 0.234 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.836213e-01 | 0.234 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.836213e-01 | 0.234 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.836213e-01 | 0.234 |
| R-HSA-162906 | HIV Infection | 5.902673e-01 | 0.229 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.924715e-01 | 0.227 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.935762e-01 | 0.227 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.968418e-01 | 0.224 |
| R-HSA-1483255 | PI Metabolism | 5.968418e-01 | 0.224 |
| R-HSA-192823 | Viral mRNA Translation | 6.000813e-01 | 0.222 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.032950e-01 | 0.219 |
| R-HSA-9833110 | RSV-host interactions | 6.064830e-01 | 0.217 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.096456e-01 | 0.215 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.127831e-01 | 0.213 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.158954e-01 | 0.210 |
| R-HSA-69239 | Synthesis of DNA | 6.158954e-01 | 0.210 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.158954e-01 | 0.210 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.158954e-01 | 0.210 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.189830e-01 | 0.208 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.189830e-01 | 0.208 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.189830e-01 | 0.208 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.220459e-01 | 0.206 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.250844e-01 | 0.204 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.250844e-01 | 0.204 |
| R-HSA-6803157 | Antimicrobial peptides | 6.280987e-01 | 0.202 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.310889e-01 | 0.200 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.326894e-01 | 0.199 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.340553e-01 | 0.198 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.399172e-01 | 0.194 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.428131e-01 | 0.192 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.485358e-01 | 0.188 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.485358e-01 | 0.188 |
| R-HSA-373760 | L1CAM interactions | 6.485358e-01 | 0.188 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.513629e-01 | 0.186 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 6.537280e-01 | 0.185 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.569496e-01 | 0.182 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.569496e-01 | 0.182 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.624475e-01 | 0.179 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.641241e-01 | 0.178 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.651636e-01 | 0.177 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.651636e-01 | 0.177 |
| R-HSA-418594 | G alpha (i) signalling events | 6.694273e-01 | 0.174 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.705308e-01 | 0.174 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.705308e-01 | 0.174 |
| R-HSA-114608 | Platelet degranulation | 6.810106e-01 | 0.167 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.985602e-01 | 0.156 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.081549e-01 | 0.150 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.105058e-01 | 0.148 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.128380e-01 | 0.147 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.174465e-01 | 0.144 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.174465e-01 | 0.144 |
| R-HSA-9664407 | Parasite infection | 7.174465e-01 | 0.144 |
| R-HSA-1632852 | Macroautophagy | 7.197231e-01 | 0.143 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.197231e-01 | 0.143 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.242220e-01 | 0.140 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.351580e-01 | 0.134 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.372930e-01 | 0.132 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.456636e-01 | 0.127 |
| R-HSA-9612973 | Autophagy | 7.537695e-01 | 0.123 |
| R-HSA-9711097 | Cellular response to starvation | 7.577258e-01 | 0.120 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.616190e-01 | 0.118 |
| R-HSA-388396 | GPCR downstream signalling | 7.683015e-01 | 0.114 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.692202e-01 | 0.114 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.819479e-01 | 0.107 |
| R-HSA-72306 | tRNA processing | 7.819479e-01 | 0.107 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.889055e-01 | 0.103 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.906102e-01 | 0.102 |
| R-HSA-611105 | Respiratory electron transport | 7.956428e-01 | 0.099 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.976617e-01 | 0.098 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.115670e-01 | 0.091 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.160996e-01 | 0.088 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.318126e-01 | 0.080 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.331732e-01 | 0.079 |
| R-HSA-372790 | Signaling by GPCR | 8.376348e-01 | 0.077 |
| R-HSA-6805567 | Keratinization | 8.385072e-01 | 0.076 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.671376e-01 | 0.062 |
| R-HSA-72312 | rRNA processing | 8.692825e-01 | 0.061 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.765227e-01 | 0.057 |
| R-HSA-72766 | Translation | 8.783815e-01 | 0.056 |
| R-HSA-449147 | Signaling by Interleukins | 8.941993e-01 | 0.049 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.972534e-01 | 0.047 |
| R-HSA-6798695 | Neutrophil degranulation | 8.985870e-01 | 0.046 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.037633e-01 | 0.044 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.071694e-01 | 0.042 |
| R-HSA-382551 | Transport of small molecules | 9.090565e-01 | 0.041 |
| R-HSA-9658195 | Leishmania infection | 9.123243e-01 | 0.040 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.123243e-01 | 0.040 |
| R-HSA-422475 | Axon guidance | 9.436084e-01 | 0.025 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.463275e-01 | 0.024 |
| R-HSA-9679506 | SARS-CoV Infections | 9.473187e-01 | 0.024 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.555535e-01 | 0.020 |
| R-HSA-9675108 | Nervous system development | 9.562173e-01 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.643939e-01 | 0.016 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.658823e-01 | 0.015 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.726372e-01 | 0.012 |
| R-HSA-168249 | Innate Immune System | 9.860540e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.881243e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.996847e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999972e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.772 | 0.129 | 1 | 0.805 |
MOS |
0.771 | 0.294 | 1 | 0.878 |
COT |
0.770 | 0.132 | 2 | 0.874 |
GRK1 |
0.768 | 0.232 | -2 | 0.784 |
CDC7 |
0.761 | 0.026 | 1 | 0.880 |
PIM3 |
0.760 | 0.055 | -3 | 0.769 |
SRPK1 |
0.755 | 0.101 | -3 | 0.705 |
BMPR1B |
0.755 | 0.127 | 1 | 0.850 |
SRPK2 |
0.754 | 0.100 | -3 | 0.651 |
SKMLCK |
0.753 | 0.053 | -2 | 0.773 |
CAMK1B |
0.753 | 0.060 | -3 | 0.799 |
NDR2 |
0.753 | 0.013 | -3 | 0.763 |
PRPK |
0.753 | -0.021 | -1 | 0.242 |
GRK6 |
0.752 | 0.066 | 1 | 0.821 |
FAM20C |
0.752 | 0.133 | 2 | 0.784 |
RSK2 |
0.752 | 0.053 | -3 | 0.738 |
PIM1 |
0.751 | 0.062 | -3 | 0.759 |
CLK2 |
0.751 | 0.126 | -3 | 0.740 |
IKKB |
0.751 | -0.018 | -2 | 0.701 |
CDKL1 |
0.749 | 0.047 | -3 | 0.733 |
CAMK2G |
0.749 | 0.035 | 2 | 0.878 |
SRPK3 |
0.749 | 0.113 | -3 | 0.677 |
NUAK2 |
0.749 | 0.055 | -3 | 0.804 |
MAPKAPK2 |
0.748 | 0.056 | -3 | 0.708 |
NDR1 |
0.747 | 0.040 | -3 | 0.774 |
NLK |
0.747 | 0.011 | 1 | 0.751 |
RAF1 |
0.746 | -0.059 | 1 | 0.765 |
WNK1 |
0.746 | 0.039 | -2 | 0.787 |
CK1E |
0.746 | 0.111 | -3 | 0.545 |
GRK5 |
0.746 | -0.042 | -3 | 0.733 |
HIPK4 |
0.745 | 0.035 | 1 | 0.734 |
DSTYK |
0.745 | -0.024 | 2 | 0.902 |
AMPKA1 |
0.745 | 0.055 | -3 | 0.795 |
BMPR2 |
0.744 | -0.100 | -2 | 0.786 |
PRKD2 |
0.744 | 0.040 | -3 | 0.749 |
CAMK2B |
0.744 | 0.063 | 2 | 0.854 |
DAPK2 |
0.744 | 0.038 | -3 | 0.786 |
ATR |
0.744 | -0.025 | 1 | 0.769 |
KIS |
0.743 | 0.053 | 1 | 0.618 |
NIK |
0.743 | 0.025 | -3 | 0.801 |
RSK4 |
0.743 | 0.067 | -3 | 0.714 |
GRK4 |
0.743 | -0.019 | -2 | 0.794 |
MARK4 |
0.742 | 0.004 | 4 | 0.813 |
GRK7 |
0.742 | 0.073 | 1 | 0.731 |
MTOR |
0.742 | -0.105 | 1 | 0.685 |
P90RSK |
0.742 | 0.010 | -3 | 0.726 |
P70S6KB |
0.741 | 0.049 | -3 | 0.762 |
ACVR2B |
0.741 | 0.105 | -2 | 0.735 |
CAMK2A |
0.741 | 0.051 | 2 | 0.862 |
TGFBR1 |
0.741 | 0.058 | -2 | 0.761 |
MAPKAPK3 |
0.741 | 0.021 | -3 | 0.730 |
CAMLCK |
0.741 | 0.011 | -2 | 0.726 |
PRKX |
0.741 | 0.074 | -3 | 0.703 |
CDKL5 |
0.741 | 0.028 | -3 | 0.723 |
BMPR1A |
0.740 | 0.099 | 1 | 0.844 |
CLK4 |
0.740 | 0.052 | -3 | 0.754 |
MST4 |
0.740 | 0.040 | 2 | 0.854 |
PKN3 |
0.739 | 0.010 | -3 | 0.748 |
AMPKA2 |
0.739 | 0.049 | -3 | 0.782 |
ALK2 |
0.739 | 0.076 | -2 | 0.762 |
PDHK4 |
0.739 | -0.212 | 1 | 0.771 |
PKACG |
0.739 | 0.016 | -2 | 0.619 |
GCN2 |
0.739 | -0.122 | 2 | 0.805 |
RIPK3 |
0.738 | -0.012 | 3 | 0.720 |
LATS2 |
0.738 | -0.011 | -5 | 0.713 |
PKN2 |
0.738 | 0.038 | -3 | 0.785 |
MLK1 |
0.738 | -0.013 | 2 | 0.830 |
ALK4 |
0.738 | 0.022 | -2 | 0.772 |
MYLK4 |
0.738 | 0.048 | -2 | 0.662 |
ACVR2A |
0.737 | 0.055 | -2 | 0.711 |
CLK1 |
0.737 | 0.063 | -3 | 0.746 |
ATM |
0.736 | -0.018 | 1 | 0.721 |
TSSK2 |
0.736 | 0.015 | -5 | 0.785 |
BRSK1 |
0.736 | 0.052 | -3 | 0.752 |
PRKD1 |
0.736 | -0.041 | -3 | 0.732 |
RSK3 |
0.736 | 0.001 | -3 | 0.717 |
ERK5 |
0.735 | -0.069 | 1 | 0.694 |
TGFBR2 |
0.735 | -0.059 | -2 | 0.717 |
GRK2 |
0.735 | 0.044 | -2 | 0.703 |
IKKA |
0.735 | -0.064 | -2 | 0.710 |
DLK |
0.735 | -0.015 | 1 | 0.767 |
CAMK2D |
0.735 | -0.037 | -3 | 0.765 |
PKACB |
0.735 | 0.038 | -2 | 0.548 |
CK2A2 |
0.734 | 0.125 | 1 | 0.805 |
ICK |
0.734 | -0.008 | -3 | 0.756 |
CHAK2 |
0.734 | -0.062 | -1 | 0.254 |
AURC |
0.734 | 0.003 | -2 | 0.528 |
HIPK1 |
0.734 | 0.072 | 1 | 0.640 |
TBK1 |
0.733 | -0.141 | 1 | 0.624 |
CK1D |
0.733 | 0.090 | -3 | 0.502 |
HUNK |
0.733 | -0.080 | 2 | 0.814 |
DYRK2 |
0.733 | 0.029 | 1 | 0.630 |
WNK3 |
0.733 | -0.081 | 1 | 0.724 |
TSSK1 |
0.732 | -0.002 | -3 | 0.802 |
BCKDK |
0.732 | -0.120 | -1 | 0.232 |
PKCD |
0.732 | -0.010 | 2 | 0.820 |
HIPK2 |
0.732 | 0.049 | 1 | 0.551 |
QSK |
0.732 | 0.020 | 4 | 0.795 |
MSK1 |
0.731 | 0.016 | -3 | 0.694 |
SIK |
0.731 | 0.027 | -3 | 0.744 |
CAMK4 |
0.731 | -0.012 | -3 | 0.787 |
RIPK1 |
0.731 | -0.060 | 1 | 0.707 |
MARK3 |
0.731 | 0.039 | 4 | 0.772 |
PAK1 |
0.731 | -0.010 | -2 | 0.660 |
QIK |
0.731 | 0.010 | -3 | 0.774 |
ULK2 |
0.731 | -0.169 | 2 | 0.798 |
NEK7 |
0.731 | -0.123 | -3 | 0.729 |
CK1A2 |
0.730 | 0.090 | -3 | 0.509 |
IRE1 |
0.730 | -0.031 | 1 | 0.707 |
LATS1 |
0.730 | 0.013 | -3 | 0.754 |
PDHK1 |
0.730 | -0.214 | 1 | 0.740 |
PIM2 |
0.730 | 0.062 | -3 | 0.725 |
IKKE |
0.730 | -0.135 | 1 | 0.619 |
PASK |
0.730 | 0.080 | -3 | 0.766 |
AKT2 |
0.730 | 0.045 | -3 | 0.692 |
PRKD3 |
0.729 | 0.019 | -3 | 0.721 |
TTBK2 |
0.729 | -0.073 | 2 | 0.740 |
MSK2 |
0.729 | -0.016 | -3 | 0.688 |
CAMK1G |
0.729 | 0.050 | -3 | 0.744 |
CK2A1 |
0.729 | 0.130 | 1 | 0.782 |
GRK3 |
0.729 | 0.053 | -2 | 0.681 |
NEK6 |
0.729 | -0.113 | -2 | 0.767 |
ANKRD3 |
0.728 | -0.056 | 1 | 0.754 |
PKCB |
0.727 | 0.010 | 2 | 0.767 |
DAPK3 |
0.727 | 0.082 | -3 | 0.777 |
PKR |
0.727 | -0.027 | 1 | 0.763 |
PLK1 |
0.727 | -0.042 | -2 | 0.702 |
AURB |
0.726 | 0.006 | -2 | 0.521 |
CDK8 |
0.726 | -0.041 | 1 | 0.623 |
BRSK2 |
0.726 | 0.009 | -3 | 0.772 |
MARK2 |
0.726 | 0.014 | 4 | 0.742 |
MLK3 |
0.726 | -0.029 | 2 | 0.784 |
MELK |
0.725 | -0.006 | -3 | 0.769 |
MASTL |
0.725 | -0.166 | -2 | 0.726 |
DCAMKL1 |
0.725 | 0.028 | -3 | 0.773 |
PKCG |
0.725 | 0.003 | 2 | 0.783 |
CDK1 |
0.725 | 0.011 | 1 | 0.598 |
DAPK1 |
0.725 | 0.083 | -3 | 0.759 |
NUAK1 |
0.725 | -0.016 | -3 | 0.765 |
MARK1 |
0.725 | 0.026 | 4 | 0.786 |
PKG2 |
0.724 | 0.009 | -2 | 0.546 |
DRAK1 |
0.724 | 0.005 | 1 | 0.736 |
MNK1 |
0.724 | -0.002 | -2 | 0.671 |
SSTK |
0.724 | 0.062 | 4 | 0.776 |
PAK3 |
0.724 | -0.050 | -2 | 0.654 |
DYRK4 |
0.723 | 0.041 | 1 | 0.568 |
CDK7 |
0.723 | -0.032 | 1 | 0.628 |
MEK1 |
0.723 | -0.085 | 2 | 0.840 |
NIM1 |
0.722 | -0.091 | 3 | 0.765 |
MNK2 |
0.722 | -0.040 | -2 | 0.661 |
MLK4 |
0.722 | -0.043 | 2 | 0.751 |
PDHK3_TYR |
0.722 | 0.155 | 4 | 0.817 |
JNK3 |
0.722 | -0.002 | 1 | 0.592 |
SGK3 |
0.722 | 0.012 | -3 | 0.718 |
PAK2 |
0.721 | -0.038 | -2 | 0.639 |
PDHK4_TYR |
0.721 | 0.202 | 2 | 0.888 |
TLK2 |
0.721 | -0.089 | 1 | 0.771 |
DYRK1B |
0.721 | 0.041 | 1 | 0.597 |
BMPR2_TYR |
0.721 | 0.308 | -1 | 0.361 |
MLK2 |
0.721 | -0.124 | 2 | 0.814 |
CAMK1D |
0.721 | 0.044 | -3 | 0.697 |
CDK19 |
0.720 | -0.036 | 1 | 0.584 |
PLK3 |
0.720 | -0.067 | 2 | 0.828 |
NEK9 |
0.720 | -0.179 | 2 | 0.826 |
ULK1 |
0.720 | -0.173 | -3 | 0.690 |
JNK2 |
0.720 | 0.001 | 1 | 0.557 |
MEKK3 |
0.720 | 0.020 | 1 | 0.705 |
CDK10 |
0.720 | 0.058 | 1 | 0.576 |
AURA |
0.720 | -0.020 | -2 | 0.499 |
VRK2 |
0.720 | -0.140 | 1 | 0.788 |
IRE2 |
0.720 | -0.037 | 2 | 0.767 |
PHKG1 |
0.719 | -0.024 | -3 | 0.785 |
PKACA |
0.719 | 0.020 | -2 | 0.496 |
SMG1 |
0.719 | -0.091 | 1 | 0.713 |
DYRK1A |
0.719 | 0.013 | 1 | 0.662 |
SMMLCK |
0.719 | 0.020 | -3 | 0.760 |
BRAF |
0.719 | -0.064 | -4 | 0.673 |
PDHK1_TYR |
0.718 | 0.196 | -1 | 0.303 |
AKT1 |
0.718 | 0.037 | -3 | 0.708 |
GAK |
0.718 | 0.080 | 1 | 0.775 |
MAP2K6_TYR |
0.717 | 0.143 | -1 | 0.280 |
CHK1 |
0.717 | -0.055 | -3 | 0.753 |
SNRK |
0.717 | -0.031 | 2 | 0.706 |
CDK5 |
0.717 | -0.009 | 1 | 0.651 |
PKCZ |
0.716 | -0.059 | 2 | 0.783 |
PKCH |
0.716 | -0.028 | 2 | 0.757 |
CDK13 |
0.716 | -0.029 | 1 | 0.590 |
PKCA |
0.716 | -0.028 | 2 | 0.762 |
DNAPK |
0.716 | -0.044 | 1 | 0.600 |
DYRK3 |
0.716 | 0.032 | 1 | 0.637 |
MPSK1 |
0.716 | 0.009 | 1 | 0.732 |
MST3 |
0.716 | 0.035 | 2 | 0.835 |
YSK4 |
0.716 | -0.103 | 1 | 0.674 |
HIPK3 |
0.715 | 0.023 | 1 | 0.610 |
MAPKAPK5 |
0.715 | -0.055 | -3 | 0.661 |
PAK6 |
0.715 | -0.024 | -2 | 0.560 |
WNK4 |
0.715 | -0.036 | -2 | 0.766 |
P38G |
0.714 | -0.007 | 1 | 0.498 |
P38A |
0.714 | -0.033 | 1 | 0.615 |
DCAMKL2 |
0.714 | -0.004 | -3 | 0.799 |
PRP4 |
0.714 | -0.023 | -3 | 0.647 |
CK1G1 |
0.714 | -0.016 | -3 | 0.527 |
EPHA6 |
0.714 | 0.212 | -1 | 0.347 |
CHAK1 |
0.713 | -0.111 | 2 | 0.761 |
TAO3 |
0.713 | -0.018 | 1 | 0.699 |
CDK18 |
0.713 | -0.030 | 1 | 0.551 |
TXK |
0.712 | 0.134 | 1 | 0.846 |
P38B |
0.712 | -0.023 | 1 | 0.550 |
MEK5 |
0.712 | -0.095 | 2 | 0.827 |
MAP2K4_TYR |
0.711 | 0.027 | -1 | 0.247 |
TLK1 |
0.711 | -0.086 | -2 | 0.790 |
PTK2 |
0.711 | 0.285 | -1 | 0.464 |
GSK3A |
0.711 | 0.002 | 4 | 0.416 |
ERK1 |
0.711 | -0.028 | 1 | 0.536 |
P70S6K |
0.710 | 0.005 | -3 | 0.678 |
CDK12 |
0.710 | -0.027 | 1 | 0.559 |
ERK2 |
0.710 | -0.041 | 1 | 0.585 |
TESK1_TYR |
0.710 | 0.045 | 3 | 0.871 |
PERK |
0.709 | -0.129 | -2 | 0.751 |
MRCKB |
0.709 | 0.051 | -3 | 0.729 |
SGK1 |
0.709 | 0.041 | -3 | 0.614 |
MOK |
0.708 | 0.080 | 1 | 0.633 |
CDK17 |
0.708 | -0.027 | 1 | 0.511 |
SYK |
0.708 | 0.259 | -1 | 0.416 |
GSK3B |
0.708 | -0.013 | 4 | 0.409 |
GCK |
0.708 | 0.017 | 1 | 0.727 |
MEKK2 |
0.708 | -0.087 | 2 | 0.806 |
ROCK2 |
0.708 | 0.055 | -3 | 0.753 |
HRI |
0.708 | -0.138 | -2 | 0.750 |
ZAK |
0.708 | -0.106 | 1 | 0.683 |
CDK9 |
0.708 | -0.046 | 1 | 0.585 |
NEK2 |
0.708 | -0.155 | 2 | 0.801 |
CDK2 |
0.707 | -0.055 | 1 | 0.670 |
TAK1 |
0.707 | 0.036 | 1 | 0.790 |
AKT3 |
0.707 | 0.035 | -3 | 0.631 |
IRAK4 |
0.707 | -0.087 | 1 | 0.688 |
MEKK1 |
0.707 | -0.120 | 1 | 0.717 |
PKCE |
0.707 | 0.026 | 2 | 0.765 |
NEK5 |
0.707 | -0.126 | 1 | 0.734 |
DMPK1 |
0.707 | 0.086 | -3 | 0.770 |
MAP2K7_TYR |
0.707 | -0.021 | 2 | 0.880 |
PHKG2 |
0.706 | 0.009 | -3 | 0.791 |
MRCKA |
0.706 | 0.042 | -3 | 0.741 |
TAO2 |
0.706 | -0.019 | 2 | 0.861 |
CK1A |
0.706 | 0.065 | -3 | 0.428 |
PINK1 |
0.706 | -0.133 | 1 | 0.791 |
FYN |
0.705 | 0.210 | -1 | 0.388 |
PLK2 |
0.705 | -0.015 | -3 | 0.677 |
PINK1_TYR |
0.705 | 0.053 | 1 | 0.765 |
HPK1 |
0.705 | 0.031 | 1 | 0.684 |
SBK |
0.705 | 0.041 | -3 | 0.605 |
CDK14 |
0.705 | -0.025 | 1 | 0.587 |
CDK3 |
0.705 | -0.010 | 1 | 0.531 |
CHK2 |
0.704 | 0.024 | -3 | 0.660 |
EPHB4 |
0.704 | 0.054 | -1 | 0.271 |
MAK |
0.704 | 0.035 | -2 | 0.658 |
CAMK1A |
0.704 | 0.019 | -3 | 0.672 |
PKMYT1_TYR |
0.703 | -0.028 | 3 | 0.836 |
BLK |
0.703 | 0.164 | -1 | 0.351 |
PKCT |
0.703 | -0.041 | 2 | 0.760 |
NEK11 |
0.703 | -0.066 | 1 | 0.691 |
TTBK1 |
0.702 | -0.102 | 2 | 0.683 |
LCK |
0.702 | 0.170 | -1 | 0.365 |
P38D |
0.702 | -0.025 | 1 | 0.509 |
IRAK1 |
0.702 | -0.141 | -1 | 0.221 |
JNK1 |
0.702 | -0.013 | 1 | 0.562 |
EPHA4 |
0.702 | 0.089 | 2 | 0.830 |
EEF2K |
0.701 | -0.000 | 3 | 0.866 |
SRMS |
0.701 | 0.028 | 1 | 0.827 |
CDK16 |
0.701 | -0.018 | 1 | 0.528 |
NEK8 |
0.701 | -0.108 | 2 | 0.826 |
BMX |
0.700 | 0.048 | -1 | 0.269 |
LRRK2 |
0.700 | -0.059 | 2 | 0.850 |
ALPHAK3 |
0.700 | 0.066 | -1 | 0.245 |
PLK4 |
0.700 | -0.148 | 2 | 0.666 |
FER |
0.699 | -0.031 | 1 | 0.843 |
PDK1 |
0.699 | -0.078 | 1 | 0.677 |
HCK |
0.699 | 0.103 | -1 | 0.336 |
KHS2 |
0.699 | 0.040 | 1 | 0.690 |
ITK |
0.699 | 0.057 | -1 | 0.295 |
LIMK2_TYR |
0.698 | -0.044 | -3 | 0.783 |
PKCI |
0.698 | -0.046 | 2 | 0.761 |
PAK5 |
0.698 | -0.048 | -2 | 0.496 |
LKB1 |
0.698 | -0.128 | -3 | 0.717 |
YES1 |
0.697 | -0.012 | -1 | 0.263 |
HASPIN |
0.697 | -0.008 | -1 | 0.176 |
ROCK1 |
0.697 | 0.051 | -3 | 0.740 |
FGR |
0.697 | -0.020 | 1 | 0.783 |
PAK4 |
0.696 | -0.044 | -2 | 0.502 |
CRIK |
0.696 | 0.059 | -3 | 0.687 |
CAMKK1 |
0.696 | -0.166 | -2 | 0.665 |
INSRR |
0.696 | 0.041 | 3 | 0.722 |
EPHB2 |
0.696 | 0.051 | -1 | 0.276 |
TNIK |
0.696 | -0.036 | 3 | 0.860 |
ABL2 |
0.695 | -0.031 | -1 | 0.259 |
LIMK1_TYR |
0.694 | -0.096 | 2 | 0.867 |
STK33 |
0.694 | -0.071 | 2 | 0.676 |
MST2 |
0.694 | -0.080 | 1 | 0.724 |
MINK |
0.694 | -0.058 | 1 | 0.686 |
EPHB1 |
0.694 | 0.019 | 1 | 0.799 |
KHS1 |
0.694 | -0.007 | 1 | 0.665 |
RET |
0.693 | -0.096 | 1 | 0.687 |
CAMKK2 |
0.693 | -0.165 | -2 | 0.656 |
FLT1 |
0.692 | 0.088 | -1 | 0.345 |
PKN1 |
0.692 | -0.020 | -3 | 0.708 |
TYRO3 |
0.692 | -0.107 | 3 | 0.771 |
HGK |
0.692 | -0.070 | 3 | 0.866 |
MET |
0.692 | 0.057 | 3 | 0.752 |
MAP3K15 |
0.692 | -0.093 | 1 | 0.650 |
CDK4 |
0.692 | -0.008 | 1 | 0.553 |
MEKK6 |
0.692 | -0.105 | 1 | 0.699 |
SLK |
0.692 | -0.067 | -2 | 0.617 |
EPHB3 |
0.691 | 0.010 | -1 | 0.276 |
CDK6 |
0.691 | -0.013 | 1 | 0.558 |
ERK7 |
0.691 | -0.030 | 2 | 0.535 |
JAK3 |
0.691 | 0.049 | 1 | 0.680 |
VRK1 |
0.691 | -0.113 | 2 | 0.828 |
MST1R |
0.691 | -0.074 | 3 | 0.784 |
TNK2 |
0.690 | -0.062 | 3 | 0.728 |
LOK |
0.690 | -0.075 | -2 | 0.647 |
ABL1 |
0.690 | -0.072 | -1 | 0.249 |
TEC |
0.689 | -0.052 | -1 | 0.209 |
EPHA7 |
0.689 | 0.056 | 2 | 0.830 |
WEE1_TYR |
0.689 | -0.021 | -1 | 0.211 |
NEK4 |
0.689 | -0.157 | 1 | 0.676 |
DDR1 |
0.689 | -0.095 | 4 | 0.736 |
MERTK |
0.689 | -0.065 | 3 | 0.740 |
CSF1R |
0.689 | -0.078 | 3 | 0.757 |
FGFR2 |
0.688 | -0.035 | 3 | 0.775 |
KDR |
0.688 | 0.012 | 3 | 0.726 |
KIT |
0.688 | -0.035 | 3 | 0.765 |
EPHA5 |
0.687 | 0.047 | 2 | 0.824 |
EPHA8 |
0.687 | 0.100 | -1 | 0.348 |
NEK1 |
0.687 | -0.138 | 1 | 0.686 |
PBK |
0.687 | -0.048 | 1 | 0.685 |
MST1 |
0.687 | -0.090 | 1 | 0.689 |
ROS1 |
0.686 | -0.114 | 3 | 0.737 |
TTK |
0.686 | -0.035 | -2 | 0.735 |
BTK |
0.686 | -0.085 | -1 | 0.257 |
YANK3 |
0.686 | -0.003 | 2 | 0.478 |
EPHA3 |
0.686 | 0.010 | 2 | 0.808 |
SRC |
0.685 | 0.053 | -1 | 0.321 |
TYK2 |
0.685 | -0.153 | 1 | 0.684 |
ZAP70 |
0.684 | 0.120 | -1 | 0.364 |
LYN |
0.684 | 0.042 | 3 | 0.698 |
FRK |
0.684 | 0.033 | -1 | 0.319 |
PTK2B |
0.683 | -0.041 | -1 | 0.210 |
EPHA2 |
0.683 | 0.100 | -1 | 0.348 |
BUB1 |
0.683 | -0.056 | -5 | 0.750 |
FGFR3 |
0.682 | -0.018 | 3 | 0.745 |
AXL |
0.682 | -0.127 | 3 | 0.737 |
ERBB4 |
0.682 | 0.106 | 1 | 0.661 |
PTK6 |
0.682 | -0.152 | -1 | 0.217 |
PDGFRB |
0.682 | -0.115 | 3 | 0.779 |
ERBB2 |
0.681 | -0.005 | 1 | 0.681 |
PKG1 |
0.681 | -0.036 | -2 | 0.451 |
RIPK2 |
0.681 | -0.150 | 1 | 0.625 |
CK1G2 |
0.681 | 0.108 | -3 | 0.465 |
TEK |
0.681 | -0.060 | 3 | 0.703 |
OSR1 |
0.680 | -0.051 | 2 | 0.781 |
JAK2 |
0.680 | -0.150 | 1 | 0.674 |
EGFR |
0.680 | 0.005 | 1 | 0.599 |
YSK1 |
0.680 | -0.095 | 2 | 0.805 |
MATK |
0.680 | -0.077 | -1 | 0.223 |
FLT3 |
0.680 | -0.090 | 3 | 0.780 |
EPHA1 |
0.679 | -0.026 | 3 | 0.730 |
LTK |
0.678 | -0.094 | 3 | 0.715 |
ALK |
0.677 | -0.095 | 3 | 0.698 |
CK1G3 |
0.677 | 0.023 | -3 | 0.389 |
MEK2 |
0.675 | -0.233 | 2 | 0.797 |
FGFR1 |
0.674 | -0.130 | 3 | 0.740 |
TNK1 |
0.674 | -0.146 | 3 | 0.749 |
BIKE |
0.674 | -0.037 | 1 | 0.645 |
DDR2 |
0.674 | -0.037 | 3 | 0.713 |
NTRK1 |
0.673 | -0.142 | -1 | 0.246 |
INSR |
0.673 | -0.078 | 3 | 0.695 |
NEK10_TYR |
0.673 | -0.130 | 1 | 0.560 |
FLT4 |
0.672 | -0.074 | 3 | 0.720 |
FGFR4 |
0.672 | -0.061 | -1 | 0.239 |
TNNI3K_TYR |
0.672 | -0.121 | 1 | 0.710 |
ASK1 |
0.671 | -0.122 | 1 | 0.641 |
CSK |
0.670 | -0.090 | 2 | 0.828 |
TAO1 |
0.670 | -0.074 | 1 | 0.605 |
PDGFRA |
0.669 | -0.176 | 3 | 0.774 |
NTRK3 |
0.668 | -0.130 | -1 | 0.232 |
MYO3B |
0.668 | -0.094 | 2 | 0.821 |
JAK1 |
0.667 | -0.132 | 1 | 0.611 |
NTRK2 |
0.667 | -0.166 | 3 | 0.732 |
IGF1R |
0.666 | -0.030 | 3 | 0.639 |
MYO3A |
0.665 | -0.097 | 1 | 0.683 |
NEK3 |
0.663 | -0.210 | 1 | 0.628 |
FES |
0.660 | -0.063 | -1 | 0.237 |
MUSK |
0.658 | -0.079 | 1 | 0.573 |
YANK2 |
0.657 | -0.015 | 2 | 0.499 |
STLK3 |
0.656 | -0.145 | 1 | 0.649 |
AAK1 |
0.651 | -0.041 | 1 | 0.536 |