Motif 596 (n=100)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYK5 | None | S189 | ochoa | Uncharacterized protein | None |
| A0JNW5 | BLTP3B | S1058 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| O00418 | EEF2K | S477 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14640 | DVL1 | S51 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14641 | DVL2 | S59 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O43745 | CHP2 | S27 | ochoa | Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520) | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269|PubMed:12226101, ECO:0000269|PubMed:18815128}. |
| O60716 | CTNND1 | S899 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75044 | SRGAP2 | S487 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75390 | CS | S190 | ochoa | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
| O75691 | UTP20 | S2601 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95613 | PCNT | S455 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P04843 | RPN1 | S514 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P06753 | TPM3 | S88 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07951 | TPM2 | S87 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P09496 | CLTA | S105 | ochoa | Clathrin light chain A (Lca) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}. |
| P12882 | MYH1 | T1195 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P15374 | UCHL3 | S161 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
| P36873 | PPP1CC | S129 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P42566 | EPS15 | S435 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46013 | MKI67 | S2395 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49792 | RANBP2 | S809 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52789 | HK2 | S122 | ochoa | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P54792 | DVL1P1 | S51 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P60880 | SNAP25 | S28 | psp | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {ECO:0000250|UniProtKB:P60881}. |
| P62136 | PPP1CA | S129 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S128 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| P78524 | DENND2B | S550 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q00535 | CDK5 | S47 | psp | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}. |
| Q01082 | SPTBN1 | S781 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01658 | DR1 | S106 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q12846 | STX4 | S208 | ochoa | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850, ECO:0000269|PubMed:36355422}. |
| Q12888 | TP53BP1 | S1665 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13137 | CALCOCO2 | S355 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q14676 | MDC1 | S422 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15042 | RAB3GAP1 | S537 | ochoa | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}. |
| Q15555 | MAPRE2 | S253 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q5JQS6 | GCSAML | S94 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5T655 | CFAP58 | S146 | ochoa | Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) | Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RW38, ECO:0000269|PubMed:32791035}. |
| Q5UIP0 | RIF1 | S1437 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1526 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q6ZNJ1 | NBEAL2 | S39 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZVD8 | PHLPP2 | S299 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q76L83 | ASXL2 | S565 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z7L9 | ZSCAN2 | S168 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q86VP1 | TAX1BP1 | S240 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86X02 | CDR2L | S344 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IVM0 | CCDC50 | S32 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
| Q8IVT2 | MISP | S78 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IY18 | SMC5 | S793 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IZU2 | WDR17 | S1198 | ochoa | WD repeat-containing protein 17 | None |
| Q8N6H7 | ARFGAP2 | S432 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NEF9 | SRFBP1 | S349 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8TDM6 | DLG5 | S725 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEJ3 | SH3RF3 | S804 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
| Q8WWI1 | LMO7 | S295 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92997 | DVL3 | S48 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96SB8 | SMC6 | S666 | ochoa | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:26983541}. |
| Q9BT81 | SOX7 | S137 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9H4M9 | EHD1 | S284 | ochoa | EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}. |
| Q9HC77 | CPAP | S556 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NP61 | ARFGAP3 | S428 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NX24 | NHP2 | S19 | ochoa | H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}. |
| Q9NZN3 | EHD3 | S284 | ochoa | EH domain-containing protein 3 (PAST homolog 3) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}. |
| Q9NZQ7 | CD274 | S195 | psp | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9P0J1 | PDP1 | S114 | ochoa | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1) | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. {ECO:0000269|PubMed:15554715, ECO:0000305|PubMed:15855260}. |
| Q9P2D1 | CHD7 | S1882 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBB4 | ATXN10 | S430 | ochoa | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) | May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:P28658, ECO:0000250|UniProtKB:Q9ER24, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:25666058}. |
| Q9UER7 | DAXX | S647 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UK61 | TASOR | S673 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKL3 | CASP8AP2 | S1667 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | T1197 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T1195 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULJ3 | ZBTB21 | S461 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULL1 | PLEKHG1 | S930 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9Y490 | TLN1 | S2127 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S2128 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y520 | PRRC2C | S1500 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6I4 | USP3 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}. |
| P48426 | PIP4K2A | S115 | Sugiyama | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}. |
| P63241 | EIF5A | S100 | Sugiyama | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| O96004 | HAND1 | S98 | ELM | Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445). {ECO:0000250|UniProtKB:Q64279, ECO:0000269|PubMed:9931445}. |
| P14314 | PRKCSH | S108 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q13428 | TCOF1 | S341 | Sugiyama | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q99426 | TBCB | S76 | Sugiyama | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| P78356 | PIP4K2B | S120 | Sugiyama | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}. |
| O60814 | H2BC12 | Y84 | EPSD | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P06899 | H2BC11 | Y84 | EPSD | Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P23527 | H2BC17 | Y84 | EPSD | Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P33778 | H2BC3 | Y84 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P58876 | H2BC5 | Y84 | EPSD | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | Y84 | EPSD | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16778 | H2BC21 | Y84 | EPSD | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q5QNW6 | H2BC18 | Y84 | EPSD | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DN03 | H2BC20P | Y84 | EPSD | Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DRA6 | H2BC19P | Y84 | EPSD | Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93079 | H2BC9 | Y84 | EPSD | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99877 | H2BC15 | Y84 | EPSD | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | Y84 | EPSD | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9P0L2 | MARK1 | S498 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| P15924 | DSP | S63 | Sugiyama | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.110223e-16 | 15.955 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.330669e-16 | 15.477 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 4.440892e-16 | 15.353 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.332268e-15 | 14.875 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.443290e-15 | 14.841 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.332268e-15 | 14.875 |
| R-HSA-5334118 | DNA methylation | 2.442491e-15 | 14.612 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.886580e-15 | 14.540 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.884182e-15 | 14.230 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 7.771561e-15 | 14.109 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.021405e-14 | 13.991 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.210143e-14 | 13.917 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.332268e-14 | 13.875 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.231548e-14 | 13.651 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.853273e-14 | 13.545 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.853273e-14 | 13.545 |
| R-HSA-73927 | Depurination | 3.630429e-14 | 13.440 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.697043e-14 | 13.432 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.407585e-14 | 13.356 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.795364e-14 | 13.237 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 7.260859e-14 | 13.139 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 7.260859e-14 | 13.139 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.031397e-13 | 12.987 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.124656e-13 | 12.949 |
| R-HSA-73928 | Depyrimidination | 1.124656e-13 | 12.949 |
| R-HSA-9710421 | Defective pyroptosis | 1.389999e-13 | 12.857 |
| R-HSA-774815 | Nucleosome assembly | 2.098322e-13 | 12.678 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.098322e-13 | 12.678 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.562395e-13 | 12.591 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.738743e-13 | 12.241 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.202816e-13 | 12.207 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.202816e-13 | 12.207 |
| R-HSA-912446 | Meiotic recombination | 6.591394e-13 | 12.181 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.026602e-13 | 12.153 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 7.884804e-13 | 12.103 |
| R-HSA-1221632 | Meiotic synapsis | 9.401369e-13 | 12.027 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 9.401369e-13 | 12.027 |
| R-HSA-157579 | Telomere Maintenance | 1.143197e-12 | 11.942 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.117773e-12 | 11.952 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.320055e-12 | 11.879 |
| R-HSA-3214847 | HATs acetylate histones | 1.434408e-12 | 11.843 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.172484e-12 | 11.663 |
| R-HSA-69481 | G2/M Checkpoints | 2.083556e-12 | 11.681 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.982059e-12 | 11.525 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.982059e-12 | 11.525 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.324674e-12 | 11.478 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.506528e-12 | 11.455 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.054534e-12 | 11.392 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.054534e-12 | 11.392 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.364176e-12 | 11.360 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.428302e-12 | 11.192 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.641665e-12 | 11.117 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 9.675372e-12 | 11.014 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.272660e-11 | 10.895 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.275735e-11 | 10.894 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.272660e-11 | 10.895 |
| R-HSA-5693538 | Homology Directed Repair | 1.351319e-11 | 10.869 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.455602e-11 | 10.837 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.455602e-11 | 10.837 |
| R-HSA-418990 | Adherens junctions interactions | 1.481992e-11 | 10.829 |
| R-HSA-73886 | Chromosome Maintenance | 1.778666e-11 | 10.750 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.258915e-11 | 10.646 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.377354e-11 | 10.624 |
| R-HSA-8852135 | Protein ubiquitination | 2.448530e-11 | 10.611 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.777112e-11 | 10.556 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.555944e-11 | 10.449 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.659750e-11 | 10.437 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.526168e-11 | 10.344 |
| R-HSA-977225 | Amyloid fiber formation | 5.095502e-11 | 10.293 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.728473e-11 | 10.242 |
| R-HSA-211000 | Gene Silencing by RNA | 6.575818e-11 | 10.182 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.939061e-11 | 10.100 |
| R-HSA-1500620 | Meiosis | 8.074375e-11 | 10.093 |
| R-HSA-421270 | Cell-cell junction organization | 9.797096e-11 | 10.009 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.065957e-10 | 9.972 |
| R-HSA-195721 | Signaling by WNT | 1.102436e-10 | 9.958 |
| R-HSA-5688426 | Deubiquitination | 1.210494e-10 | 9.917 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.275550e-10 | 9.894 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.415448e-10 | 9.849 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.722341e-10 | 9.764 |
| R-HSA-73884 | Base Excision Repair | 1.551071e-10 | 9.809 |
| R-HSA-68875 | Mitotic Prophase | 2.505107e-10 | 9.601 |
| R-HSA-1500931 | Cell-Cell communication | 2.536720e-10 | 9.596 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.346476e-10 | 9.475 |
| R-HSA-446728 | Cell junction organization | 3.835890e-10 | 9.416 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.092372e-10 | 9.388 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.092372e-10 | 9.388 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.092372e-10 | 9.388 |
| R-HSA-9609690 | HCMV Early Events | 4.549749e-10 | 9.342 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.125608e-10 | 9.213 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.030574e-10 | 9.095 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.030574e-10 | 9.095 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.733742e-09 | 8.761 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.431843e-09 | 8.353 |
| R-HSA-69306 | DNA Replication | 3.768714e-09 | 8.424 |
| R-HSA-9610379 | HCMV Late Events | 4.859629e-09 | 8.313 |
| R-HSA-9609646 | HCMV Infection | 8.033004e-09 | 8.095 |
| R-HSA-1474165 | Reproduction | 8.468369e-09 | 8.072 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.360931e-08 | 7.866 |
| R-HSA-68886 | M Phase | 2.626827e-08 | 7.581 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.304278e-08 | 7.481 |
| R-HSA-1640170 | Cell Cycle | 3.641288e-08 | 7.439 |
| R-HSA-4839726 | Chromatin organization | 6.385674e-08 | 7.195 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.500874e-07 | 6.824 |
| R-HSA-2559583 | Cellular Senescence | 1.876498e-07 | 6.727 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.914694e-07 | 6.718 |
| R-HSA-157118 | Signaling by NOTCH | 3.429150e-07 | 6.465 |
| R-HSA-597592 | Post-translational protein modification | 3.581352e-07 | 6.446 |
| R-HSA-73894 | DNA Repair | 5.081974e-07 | 6.294 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.917272e-07 | 6.101 |
| R-HSA-8939211 | ESR-mediated signaling | 2.231367e-06 | 5.651 |
| R-HSA-162582 | Signal Transduction | 4.457111e-06 | 5.351 |
| R-HSA-5663205 | Infectious disease | 5.296632e-06 | 5.276 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 5.755436e-06 | 5.240 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.831891e-06 | 5.165 |
| R-HSA-9824446 | Viral Infection Pathways | 1.458450e-05 | 4.836 |
| R-HSA-1280218 | Adaptive Immune System | 1.591027e-05 | 4.798 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.625237e-05 | 4.064 |
| R-HSA-201688 | WNT mediated activation of DVL | 9.112521e-05 | 4.040 |
| R-HSA-392499 | Metabolism of proteins | 9.906721e-05 | 4.004 |
| R-HSA-4641258 | Degradation of DVL | 2.830827e-04 | 3.548 |
| R-HSA-4086400 | PCP/CE pathway | 3.779919e-04 | 3.423 |
| R-HSA-9664420 | Killing mechanisms | 4.050130e-04 | 3.393 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 4.050130e-04 | 3.393 |
| R-HSA-1643685 | Disease | 9.125818e-04 | 3.040 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.067039e-03 | 2.972 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.703038e-03 | 2.769 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 1.703038e-03 | 2.769 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 2.331031e-03 | 2.632 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 2.331031e-03 | 2.632 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.551325e-03 | 2.593 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 2.807688e-03 | 2.552 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 2.807688e-03 | 2.552 |
| R-HSA-212436 | Generic Transcription Pathway | 2.973728e-03 | 2.527 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 3.326155e-03 | 2.478 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.581724e-03 | 2.446 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 3.326155e-03 | 2.478 |
| R-HSA-9909396 | Circadian clock | 4.054362e-03 | 2.392 |
| R-HSA-163560 | Triglyceride catabolism | 3.581724e-03 | 2.446 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.318919e-03 | 2.365 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.657586e-03 | 2.332 |
| R-HSA-74160 | Gene expression (Transcription) | 5.390665e-03 | 2.268 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.739191e-03 | 2.241 |
| R-HSA-2262752 | Cellular responses to stress | 6.167050e-03 | 2.210 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 6.524932e-03 | 2.185 |
| R-HSA-199991 | Membrane Trafficking | 7.544468e-03 | 2.122 |
| R-HSA-9766229 | Degradation of CDH1 | 7.773817e-03 | 2.109 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.980313e-03 | 2.098 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 8.076667e-03 | 2.093 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 8.908611e-03 | 2.050 |
| R-HSA-445355 | Smooth Muscle Contraction | 9.338128e-03 | 2.030 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.107343e-02 | 1.956 |
| R-HSA-8979227 | Triglyceride metabolism | 1.200624e-02 | 1.921 |
| R-HSA-449836 | Other interleukin signaling | 1.259747e-02 | 1.900 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 1.360728e-02 | 1.866 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.393748e-02 | 1.856 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.393748e-02 | 1.856 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.393748e-02 | 1.856 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.393748e-02 | 1.856 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.393748e-02 | 1.856 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 1.465108e-02 | 1.834 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.572834e-02 | 1.803 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.654892e-02 | 1.781 |
| R-HSA-168256 | Immune System | 1.675689e-02 | 1.776 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.153515e-02 | 1.667 |
| R-HSA-5689603 | UCH proteinases | 2.173102e-02 | 1.663 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.308902e-02 | 1.637 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.368119e-02 | 1.626 |
| R-HSA-180024 | DARPP-32 events | 2.549128e-02 | 1.594 |
| R-HSA-390522 | Striated Muscle Contraction | 3.255358e-02 | 1.487 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.897313e-02 | 1.538 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.819814e-02 | 1.550 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.006415e-02 | 1.397 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.743440e-02 | 1.562 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.108574e-02 | 1.507 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.255358e-02 | 1.487 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.158875e-02 | 1.500 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.404822e-02 | 1.468 |
| R-HSA-5673000 | RAF activation | 3.404822e-02 | 1.468 |
| R-HSA-1266738 | Developmental Biology | 3.262474e-02 | 1.486 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.550595e-02 | 1.450 |
| R-HSA-9733709 | Cardiogenesis | 3.108574e-02 | 1.507 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.727752e-02 | 1.429 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.099462e-02 | 1.387 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.190818e-02 | 1.378 |
| R-HSA-201556 | Signaling by ALK | 4.190818e-02 | 1.378 |
| R-HSA-70171 | Glycolysis | 4.385123e-02 | 1.358 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.522472e-02 | 1.345 |
| R-HSA-9694548 | Maturation of spike protein | 4.522472e-02 | 1.345 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.781089e-02 | 1.320 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 4.794451e-02 | 1.319 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 4.794451e-02 | 1.319 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.194061e-02 | 1.284 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.194061e-02 | 1.284 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.391883e-02 | 1.268 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.460510e-02 | 1.263 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 5.460510e-02 | 1.263 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.460510e-02 | 1.263 |
| R-HSA-69275 | G2/M Transition | 5.698888e-02 | 1.244 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.863468e-02 | 1.232 |
| R-HSA-68877 | Mitotic Prometaphase | 6.285981e-02 | 1.202 |
| R-HSA-70326 | Glucose metabolism | 6.532107e-02 | 1.185 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.698101e-02 | 1.174 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.698101e-02 | 1.174 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.724532e-02 | 1.172 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 6.778803e-02 | 1.169 |
| R-HSA-114516 | Disinhibition of SNARE formation | 6.778803e-02 | 1.169 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.892538e-02 | 1.162 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.245736e-02 | 1.140 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.254879e-02 | 1.139 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.378702e-02 | 1.132 |
| R-HSA-196025 | Formation of annular gap junctions | 7.431101e-02 | 1.129 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 7.431101e-02 | 1.129 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.431101e-02 | 1.129 |
| R-HSA-190873 | Gap junction degradation | 8.078874e-02 | 1.093 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 8.078874e-02 | 1.093 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.271592e-02 | 1.082 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.667916e-02 | 1.062 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 8.721660e-02 | 1.059 |
| R-HSA-9762292 | Regulation of CDH11 function | 8.722154e-02 | 1.059 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 8.722154e-02 | 1.059 |
| R-HSA-9683686 | Maturation of spike protein | 8.722154e-02 | 1.059 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.933084e-02 | 1.049 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.933084e-02 | 1.049 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 8.933084e-02 | 1.049 |
| R-HSA-373755 | Semaphorin interactions | 8.933084e-02 | 1.049 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.187223e-01 | 0.925 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.310188e-01 | 0.883 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.310188e-01 | 0.883 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.431451e-01 | 0.844 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 9.576348e-02 | 1.019 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.112587e-01 | 0.954 |
| R-HSA-380287 | Centrosome maturation | 1.158004e-01 | 0.936 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.415583e-01 | 0.849 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.415583e-01 | 0.849 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.487835e-01 | 0.827 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.536415e-01 | 0.813 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.360972e-02 | 1.029 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.047492e-01 | 0.980 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.187223e-01 | 0.925 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.833767e-01 | 0.737 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.062534e-01 | 0.974 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.491453e-01 | 0.826 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.491453e-01 | 0.826 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.785270e-01 | 0.748 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.367188e-01 | 0.864 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.668969e-01 | 0.778 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.001238e-01 | 0.999 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.512085e-01 | 0.820 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.062534e-01 | 0.974 |
| R-HSA-9659379 | Sensory processing of sound | 1.250217e-01 | 0.903 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.610209e-01 | 0.793 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.431451e-01 | 0.844 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.733645e-01 | 0.761 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.105871e-01 | 0.956 |
| R-HSA-8964038 | LDL clearance | 1.785270e-01 | 0.748 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.415583e-01 | 0.849 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.248919e-01 | 0.903 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.310188e-01 | 0.883 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.785270e-01 | 0.748 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.168087e-01 | 0.933 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.610209e-01 | 0.793 |
| R-HSA-422475 | Axon guidance | 1.040093e-01 | 0.983 |
| R-HSA-373753 | Nephrin family interactions | 1.610209e-01 | 0.793 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 1.785270e-01 | 0.748 |
| R-HSA-9675108 | Nervous system development | 1.322109e-01 | 0.879 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.620668e-01 | 0.790 |
| R-HSA-9658195 | Leishmania infection | 1.620668e-01 | 0.790 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.785270e-01 | 0.748 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.203887e-01 | 0.919 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 1.439582e-01 | 0.842 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.563180e-01 | 0.806 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 1.609858e-01 | 0.793 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.811534e-01 | 0.742 |
| R-HSA-2028269 | Signaling by Hippo | 1.431451e-01 | 0.844 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.439582e-01 | 0.842 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.585304e-01 | 0.800 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.303881e-01 | 0.885 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.842815e-01 | 0.735 |
| R-HSA-1483255 | PI Metabolism | 1.884148e-01 | 0.725 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.899960e-01 | 0.721 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.899960e-01 | 0.721 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.899960e-01 | 0.721 |
| R-HSA-111885 | Opioid Signalling | 1.934721e-01 | 0.713 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.996311e-01 | 0.700 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.011286e-01 | 0.697 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.013064e-01 | 0.696 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.013064e-01 | 0.696 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.032168e-01 | 0.692 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.050154e-01 | 0.688 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.061901e-01 | 0.686 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.069027e-01 | 0.684 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.069027e-01 | 0.684 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.069027e-01 | 0.684 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.069027e-01 | 0.684 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.087450e-01 | 0.680 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.124602e-01 | 0.673 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.179790e-01 | 0.662 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.179790e-01 | 0.662 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 2.179790e-01 | 0.662 |
| R-HSA-397014 | Muscle contraction | 2.231969e-01 | 0.651 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.234595e-01 | 0.651 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.234595e-01 | 0.651 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.289020e-01 | 0.640 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.289020e-01 | 0.640 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.289020e-01 | 0.640 |
| R-HSA-182971 | EGFR downregulation | 2.289020e-01 | 0.640 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.289020e-01 | 0.640 |
| R-HSA-68882 | Mitotic Anaphase | 2.305599e-01 | 0.637 |
| R-HSA-373760 | L1CAM interactions | 2.318711e-01 | 0.635 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.324079e-01 | 0.634 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.343066e-01 | 0.630 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.343066e-01 | 0.630 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.343066e-01 | 0.630 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.344523e-01 | 0.630 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.396737e-01 | 0.620 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.396737e-01 | 0.620 |
| R-HSA-354192 | Integrin signaling | 2.396737e-01 | 0.620 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.396737e-01 | 0.620 |
| R-HSA-8951664 | Neddylation | 2.398272e-01 | 0.620 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.447935e-01 | 0.611 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.450036e-01 | 0.611 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.450036e-01 | 0.611 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.450036e-01 | 0.611 |
| R-HSA-6798695 | Neutrophil degranulation | 2.455359e-01 | 0.610 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.499231e-01 | 0.602 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.499718e-01 | 0.602 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.502963e-01 | 0.602 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.502963e-01 | 0.602 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.502963e-01 | 0.602 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.502963e-01 | 0.602 |
| R-HSA-162906 | HIV Infection | 2.510312e-01 | 0.600 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.555523e-01 | 0.593 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.555523e-01 | 0.593 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.555523e-01 | 0.593 |
| R-HSA-169911 | Regulation of Apoptosis | 2.555523e-01 | 0.593 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.555523e-01 | 0.593 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.607718e-01 | 0.584 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.607718e-01 | 0.584 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.607718e-01 | 0.584 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.607718e-01 | 0.584 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.655237e-01 | 0.576 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.659550e-01 | 0.575 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.659550e-01 | 0.575 |
| R-HSA-4641257 | Degradation of AXIN | 2.659550e-01 | 0.575 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.659550e-01 | 0.575 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.659550e-01 | 0.575 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.711022e-01 | 0.567 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.762136e-01 | 0.559 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.762136e-01 | 0.559 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.762136e-01 | 0.559 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.762136e-01 | 0.559 |
| R-HSA-69541 | Stabilization of p53 | 2.762136e-01 | 0.559 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.762136e-01 | 0.559 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.810795e-01 | 0.551 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.812894e-01 | 0.551 |
| R-HSA-9646399 | Aggrephagy | 2.812894e-01 | 0.551 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.812894e-01 | 0.551 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.812894e-01 | 0.551 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.812894e-01 | 0.551 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.812894e-01 | 0.551 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 2.812894e-01 | 0.551 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.863300e-01 | 0.543 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.863300e-01 | 0.543 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.863300e-01 | 0.543 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.863300e-01 | 0.543 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.864570e-01 | 0.543 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.913356e-01 | 0.536 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.913356e-01 | 0.536 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.913356e-01 | 0.536 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.913356e-01 | 0.536 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.913356e-01 | 0.536 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.913356e-01 | 0.536 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.913356e-01 | 0.536 |
| R-HSA-165159 | MTOR signalling | 2.963063e-01 | 0.528 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.991973e-01 | 0.524 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.012425e-01 | 0.521 |
| R-HSA-190828 | Gap junction trafficking | 3.061444e-01 | 0.514 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.061444e-01 | 0.514 |
| R-HSA-9907900 | Proteasome assembly | 3.061444e-01 | 0.514 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.110122e-01 | 0.507 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.110122e-01 | 0.507 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.110122e-01 | 0.507 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.110122e-01 | 0.507 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.110122e-01 | 0.507 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.110122e-01 | 0.507 |
| R-HSA-9824272 | Somitogenesis | 3.110122e-01 | 0.507 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.158461e-01 | 0.501 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.158461e-01 | 0.501 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.158461e-01 | 0.501 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.158461e-01 | 0.501 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.158461e-01 | 0.501 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.158461e-01 | 0.501 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.158461e-01 | 0.501 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.158461e-01 | 0.501 |
| R-HSA-75153 | Apoptotic execution phase | 3.158461e-01 | 0.501 |
| R-HSA-437239 | Recycling pathway of L1 | 3.206464e-01 | 0.494 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.206464e-01 | 0.494 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.206464e-01 | 0.494 |
| R-HSA-166520 | Signaling by NTRKs | 3.249508e-01 | 0.488 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.254133e-01 | 0.488 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.301471e-01 | 0.481 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.301471e-01 | 0.481 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.301471e-01 | 0.481 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.301471e-01 | 0.481 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.348480e-01 | 0.475 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.395161e-01 | 0.469 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.395161e-01 | 0.469 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.395161e-01 | 0.469 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.441518e-01 | 0.463 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.441518e-01 | 0.463 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.441518e-01 | 0.463 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.487552e-01 | 0.457 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.487552e-01 | 0.457 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.487552e-01 | 0.457 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.533266e-01 | 0.452 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.578662e-01 | 0.446 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.578662e-01 | 0.446 |
| R-HSA-109581 | Apoptosis | 3.605827e-01 | 0.443 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.623742e-01 | 0.441 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.623742e-01 | 0.441 |
| R-HSA-177929 | Signaling by EGFR | 3.623742e-01 | 0.441 |
| R-HSA-75893 | TNF signaling | 3.623742e-01 | 0.441 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.668508e-01 | 0.436 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.668508e-01 | 0.436 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.757109e-01 | 0.425 |
| R-HSA-191859 | snRNP Assembly | 3.757109e-01 | 0.425 |
| R-HSA-180786 | Extension of Telomeres | 3.757109e-01 | 0.425 |
| R-HSA-351202 | Metabolism of polyamines | 3.800947e-01 | 0.420 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.844480e-01 | 0.415 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.844480e-01 | 0.415 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.844480e-01 | 0.415 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.887710e-01 | 0.410 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.887710e-01 | 0.410 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.887710e-01 | 0.410 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.887710e-01 | 0.410 |
| R-HSA-1268020 | Mitochondrial protein import | 3.887710e-01 | 0.410 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.930639e-01 | 0.406 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.015603e-01 | 0.396 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.015603e-01 | 0.396 |
| R-HSA-168255 | Influenza Infection | 4.053459e-01 | 0.392 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.222889e-01 | 0.374 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.222889e-01 | 0.374 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.222889e-01 | 0.374 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.263484e-01 | 0.370 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.263484e-01 | 0.370 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.263484e-01 | 0.370 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.271764e-01 | 0.369 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.303797e-01 | 0.366 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.303797e-01 | 0.366 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.303797e-01 | 0.366 |
| R-HSA-5617833 | Cilium Assembly | 4.319719e-01 | 0.365 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.343828e-01 | 0.362 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.343828e-01 | 0.362 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.343828e-01 | 0.362 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.383581e-01 | 0.358 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.423057e-01 | 0.354 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.423057e-01 | 0.354 |
| R-HSA-5619084 | ABC transporter disorders | 4.539842e-01 | 0.343 |
| R-HSA-191273 | Cholesterol biosynthesis | 4.539842e-01 | 0.343 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.616348e-01 | 0.336 |
| R-HSA-6806834 | Signaling by MET | 4.616348e-01 | 0.336 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.691792e-01 | 0.329 |
| R-HSA-5357801 | Programmed Cell Death | 4.695514e-01 | 0.328 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.729120e-01 | 0.325 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.802998e-01 | 0.318 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.806228e-01 | 0.318 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.875849e-01 | 0.312 |
| R-HSA-70268 | Pyruvate metabolism | 4.911894e-01 | 0.309 |
| R-HSA-9663891 | Selective autophagy | 4.947687e-01 | 0.306 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.018528e-01 | 0.299 |
| R-HSA-202424 | Downstream TCR signaling | 5.018528e-01 | 0.299 |
| R-HSA-391251 | Protein folding | 5.122946e-01 | 0.290 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.122946e-01 | 0.290 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.122946e-01 | 0.290 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.191350e-01 | 0.285 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.225195e-01 | 0.282 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.258803e-01 | 0.279 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.292177e-01 | 0.276 |
| R-HSA-72312 | rRNA processing | 5.295133e-01 | 0.276 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.325319e-01 | 0.274 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.358228e-01 | 0.271 |
| R-HSA-422356 | Regulation of insulin secretion | 5.358228e-01 | 0.271 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.413520e-01 | 0.267 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.423361e-01 | 0.266 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.423361e-01 | 0.266 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.455587e-01 | 0.263 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.487587e-01 | 0.261 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.530130e-01 | 0.257 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.550920e-01 | 0.256 |
| R-HSA-9833110 | RSV-host interactions | 5.582256e-01 | 0.253 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.608109e-01 | 0.251 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.674955e-01 | 0.246 |
| R-HSA-69239 | Synthesis of DNA | 5.674955e-01 | 0.246 |
| R-HSA-202403 | TCR signaling | 5.765726e-01 | 0.239 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.825189e-01 | 0.235 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.883824e-01 | 0.230 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.912834e-01 | 0.228 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.970249e-01 | 0.224 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.082690e-01 | 0.216 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.133697e-01 | 0.212 |
| R-HSA-3371556 | Cellular response to heat stress | 6.137739e-01 | 0.212 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.137739e-01 | 0.212 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.218878e-01 | 0.206 |
| R-HSA-69206 | G1/S Transition | 6.272030e-01 | 0.203 |
| R-HSA-194138 | Signaling by VEGF | 6.272030e-01 | 0.203 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.280025e-01 | 0.202 |
| R-HSA-114608 | Platelet degranulation | 6.324441e-01 | 0.199 |
| R-HSA-1483257 | Phospholipid metabolism | 6.508685e-01 | 0.187 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.525671e-01 | 0.185 |
| R-HSA-163685 | Integration of energy metabolism | 6.599913e-01 | 0.180 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.647753e-01 | 0.177 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.647753e-01 | 0.177 |
| R-HSA-6807070 | PTEN Regulation | 6.671422e-01 | 0.176 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.694926e-01 | 0.174 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.694926e-01 | 0.174 |
| R-HSA-9664407 | Parasite infection | 6.694926e-01 | 0.174 |
| R-HSA-109582 | Hemostasis | 6.715426e-01 | 0.173 |
| R-HSA-1632852 | Macroautophagy | 6.718265e-01 | 0.173 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.718265e-01 | 0.173 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.764454e-01 | 0.170 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.764454e-01 | 0.170 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.809999e-01 | 0.167 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.854908e-01 | 0.164 |
| R-HSA-69242 | S Phase | 6.899190e-01 | 0.161 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.917170e-01 | 0.160 |
| R-HSA-9758941 | Gastrulation | 6.921099e-01 | 0.160 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.964458e-01 | 0.157 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.985910e-01 | 0.156 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.985910e-01 | 0.156 |
| R-HSA-9609507 | Protein localization | 7.007211e-01 | 0.154 |
| R-HSA-73887 | Death Receptor Signaling | 7.028364e-01 | 0.153 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.028364e-01 | 0.153 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.049368e-01 | 0.152 |
| R-HSA-9612973 | Autophagy | 7.070225e-01 | 0.151 |
| R-HSA-162587 | HIV Life Cycle | 7.090936e-01 | 0.149 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.111502e-01 | 0.148 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.229491e-01 | 0.141 |
| R-HSA-5619102 | SLC transporter disorders | 7.290227e-01 | 0.137 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.366099e-01 | 0.133 |
| R-HSA-72306 | tRNA processing | 7.366099e-01 | 0.133 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.384736e-01 | 0.132 |
| R-HSA-168249 | Innate Immune System | 7.398906e-01 | 0.131 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.439866e-01 | 0.128 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.457985e-01 | 0.127 |
| R-HSA-9679506 | SARS-CoV Infections | 7.733010e-01 | 0.112 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.916810e-01 | 0.101 |
| R-HSA-6805567 | Keratinization | 7.975272e-01 | 0.098 |
| R-HSA-418594 | G alpha (i) signalling events | 8.053643e-01 | 0.094 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.268916e-01 | 0.083 |
| R-HSA-72766 | Translation | 8.272957e-01 | 0.082 |
| R-HSA-449147 | Signaling by Interleukins | 8.358047e-01 | 0.078 |
| R-HSA-8953854 | Metabolism of RNA | 8.566284e-01 | 0.067 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.698777e-01 | 0.061 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.797166e-01 | 0.056 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.122222e-01 | 0.040 |
| R-HSA-8957322 | Metabolism of steroids | 9.128494e-01 | 0.040 |
| R-HSA-913531 | Interferon Signaling | 9.433673e-01 | 0.025 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.531524e-01 | 0.021 |
| R-HSA-556833 | Metabolism of lipids | 9.594450e-01 | 0.018 |
| R-HSA-112316 | Neuronal System | 9.693356e-01 | 0.014 |
| R-HSA-388396 | GPCR downstream signalling | 9.775002e-01 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 9.866794e-01 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.896985e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.940229e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.989225e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.995646e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.805 | 0.179 | 2 | 0.810 |
DSTYK |
0.801 | 0.185 | 2 | 0.825 |
MST4 |
0.800 | 0.268 | 2 | 0.846 |
CLK3 |
0.797 | 0.229 | 1 | 0.662 |
RAF1 |
0.795 | 0.130 | 1 | 0.787 |
IRE2 |
0.794 | 0.295 | 2 | 0.731 |
PKCD |
0.793 | 0.219 | 2 | 0.796 |
NEK6 |
0.792 | 0.154 | -2 | 0.761 |
SRPK1 |
0.792 | 0.239 | -3 | 0.646 |
MTOR |
0.791 | 0.079 | 1 | 0.693 |
SRPK2 |
0.791 | 0.233 | -3 | 0.584 |
IRE1 |
0.790 | 0.245 | 1 | 0.699 |
SRPK3 |
0.790 | 0.280 | -3 | 0.636 |
MLK1 |
0.790 | 0.163 | 2 | 0.790 |
NLK |
0.789 | 0.107 | 1 | 0.687 |
WNK1 |
0.789 | 0.162 | -2 | 0.803 |
NEK7 |
0.789 | 0.119 | -3 | 0.802 |
TBK1 |
0.788 | 0.075 | 1 | 0.757 |
NUAK2 |
0.788 | 0.121 | -3 | 0.747 |
IKKB |
0.788 | 0.018 | -2 | 0.721 |
ULK2 |
0.788 | 0.074 | 2 | 0.704 |
MLK3 |
0.786 | 0.207 | 2 | 0.757 |
IKKE |
0.785 | 0.080 | 1 | 0.767 |
PKN2 |
0.785 | 0.164 | -3 | 0.744 |
PRPK |
0.784 | -0.065 | -1 | 0.808 |
GCN2 |
0.784 | -0.031 | 2 | 0.708 |
PKN3 |
0.784 | 0.065 | -3 | 0.727 |
CDKL1 |
0.783 | 0.057 | -3 | 0.702 |
NIK |
0.783 | 0.150 | -3 | 0.797 |
PKCB |
0.783 | 0.203 | 2 | 0.766 |
NEK9 |
0.782 | 0.123 | 2 | 0.778 |
BMPR2 |
0.782 | 0.014 | -2 | 0.789 |
PIM3 |
0.782 | 0.030 | -3 | 0.738 |
PDHK1 |
0.781 | 0.013 | 1 | 0.784 |
MARK4 |
0.781 | 0.031 | 4 | 0.772 |
BCKDK |
0.781 | 0.056 | -1 | 0.842 |
CDK5 |
0.781 | 0.148 | 1 | 0.548 |
ATR |
0.780 | 0.011 | 1 | 0.734 |
NEK2 |
0.780 | 0.190 | 2 | 0.758 |
PKR |
0.780 | 0.221 | 1 | 0.740 |
PDHK4 |
0.780 | -0.111 | 1 | 0.764 |
WNK3 |
0.780 | 0.023 | 1 | 0.766 |
CHAK1 |
0.779 | 0.205 | 2 | 0.684 |
PKCA |
0.779 | 0.199 | 2 | 0.756 |
MOS |
0.779 | -0.054 | 1 | 0.709 |
CHAK2 |
0.779 | 0.089 | -1 | 0.818 |
PKCG |
0.778 | 0.186 | 2 | 0.747 |
AMPKA1 |
0.778 | 0.052 | -3 | 0.752 |
PIM1 |
0.777 | 0.070 | -3 | 0.692 |
TGFBR2 |
0.777 | -0.003 | -2 | 0.673 |
MLK4 |
0.777 | 0.145 | 2 | 0.705 |
TNIK |
0.776 | 0.459 | 3 | 0.777 |
ULK1 |
0.776 | -0.001 | -3 | 0.764 |
CDK1 |
0.775 | 0.107 | 1 | 0.463 |
CAMK1B |
0.775 | -0.038 | -3 | 0.772 |
YSK4 |
0.775 | 0.145 | 1 | 0.735 |
KHS2 |
0.775 | 0.485 | 1 | 0.797 |
CDC7 |
0.775 | -0.121 | 1 | 0.676 |
IKKA |
0.775 | -0.003 | -2 | 0.712 |
HGK |
0.775 | 0.441 | 3 | 0.777 |
PRKD2 |
0.775 | 0.061 | -3 | 0.657 |
PKCH |
0.774 | 0.162 | 2 | 0.725 |
QIK |
0.774 | 0.050 | -3 | 0.740 |
RIPK3 |
0.774 | -0.061 | 3 | 0.525 |
NUAK1 |
0.774 | 0.029 | -3 | 0.711 |
CDKL5 |
0.773 | 0.036 | -3 | 0.683 |
CAMK2G |
0.773 | -0.077 | 2 | 0.721 |
PINK1 |
0.773 | 0.152 | 1 | 0.731 |
ERK5 |
0.773 | -0.035 | 1 | 0.631 |
AMPKA2 |
0.773 | 0.045 | -3 | 0.723 |
HRI |
0.773 | 0.152 | -2 | 0.756 |
EEF2K |
0.773 | 0.416 | 3 | 0.831 |
TSSK1 |
0.772 | 0.053 | -3 | 0.764 |
NDR1 |
0.772 | 0.007 | -3 | 0.739 |
TSSK2 |
0.772 | 0.053 | -5 | 0.723 |
MINK |
0.772 | 0.419 | 1 | 0.785 |
ANKRD3 |
0.772 | 0.025 | 1 | 0.758 |
QSK |
0.772 | 0.037 | 4 | 0.765 |
CLK1 |
0.771 | 0.129 | -3 | 0.656 |
CDK2 |
0.771 | 0.107 | 1 | 0.534 |
PRKD1 |
0.771 | 0.011 | -3 | 0.688 |
PKCZ |
0.771 | 0.121 | 2 | 0.749 |
HUNK |
0.771 | -0.082 | 2 | 0.666 |
MEKK1 |
0.770 | 0.143 | 1 | 0.757 |
SIK |
0.770 | 0.036 | -3 | 0.677 |
MLK2 |
0.770 | 0.006 | 2 | 0.770 |
MARK3 |
0.769 | 0.047 | 4 | 0.743 |
TAO3 |
0.769 | 0.247 | 1 | 0.714 |
ATM |
0.769 | -0.008 | 1 | 0.695 |
DLK |
0.769 | -0.027 | 1 | 0.711 |
KHS1 |
0.769 | 0.441 | 1 | 0.792 |
TAO2 |
0.769 | 0.314 | 2 | 0.823 |
CDK3 |
0.769 | 0.121 | 1 | 0.414 |
MST3 |
0.768 | 0.224 | 2 | 0.807 |
PHKG2 |
0.768 | 0.158 | -3 | 0.708 |
GCK |
0.768 | 0.354 | 1 | 0.783 |
FAM20C |
0.768 | 0.026 | 2 | 0.530 |
MAPKAPK3 |
0.768 | 0.002 | -3 | 0.667 |
GRK5 |
0.768 | -0.114 | -3 | 0.783 |
MEKK2 |
0.768 | 0.144 | 2 | 0.736 |
GRK6 |
0.767 | -0.055 | 1 | 0.690 |
DAPK2 |
0.767 | -0.041 | -3 | 0.772 |
IRAK4 |
0.767 | 0.117 | 1 | 0.707 |
NIM1 |
0.767 | -0.035 | 3 | 0.553 |
PHKG1 |
0.767 | 0.056 | -3 | 0.729 |
CAMLCK |
0.767 | -0.060 | -2 | 0.744 |
MARK2 |
0.766 | 0.024 | 4 | 0.701 |
PKCT |
0.766 | 0.143 | 2 | 0.736 |
PRKD3 |
0.766 | 0.037 | -3 | 0.643 |
BRAF |
0.766 | 0.082 | -4 | 0.808 |
NDR2 |
0.766 | -0.073 | -3 | 0.741 |
CLK4 |
0.765 | 0.056 | -3 | 0.684 |
ICK |
0.765 | -0.013 | -3 | 0.724 |
DNAPK |
0.765 | 0.060 | 1 | 0.729 |
SKMLCK |
0.765 | -0.055 | -2 | 0.764 |
CLK2 |
0.765 | 0.166 | -3 | 0.668 |
CDK13 |
0.765 | 0.076 | 1 | 0.503 |
NEK5 |
0.765 | 0.144 | 1 | 0.761 |
MELK |
0.764 | 0.014 | -3 | 0.707 |
ZAK |
0.764 | 0.101 | 1 | 0.699 |
HPK1 |
0.764 | 0.352 | 1 | 0.770 |
WNK4 |
0.764 | 0.076 | -2 | 0.784 |
MARK1 |
0.764 | 0.014 | 4 | 0.768 |
CDK8 |
0.764 | -0.027 | 1 | 0.533 |
RSK2 |
0.763 | -0.018 | -3 | 0.669 |
PERK |
0.763 | 0.025 | -2 | 0.744 |
RIPK1 |
0.763 | -0.100 | 1 | 0.700 |
MEKK3 |
0.763 | 0.039 | 1 | 0.714 |
PKCE |
0.763 | 0.198 | 2 | 0.739 |
CDK6 |
0.763 | 0.172 | 1 | 0.486 |
MNK2 |
0.762 | 0.027 | -2 | 0.685 |
P70S6KB |
0.761 | -0.025 | -3 | 0.708 |
CAMK2D |
0.761 | -0.060 | -3 | 0.732 |
MNK1 |
0.761 | 0.063 | -2 | 0.693 |
MST2 |
0.761 | 0.212 | 1 | 0.775 |
HIPK4 |
0.761 | -0.032 | 1 | 0.659 |
TTBK2 |
0.761 | -0.106 | 2 | 0.585 |
MEK5 |
0.761 | 0.048 | 2 | 0.740 |
AKT2 |
0.761 | 0.056 | -3 | 0.600 |
PKCI |
0.761 | 0.146 | 2 | 0.733 |
BMPR1B |
0.761 | -0.010 | 1 | 0.609 |
PIM2 |
0.760 | 0.068 | -3 | 0.653 |
AKT1 |
0.760 | 0.080 | -3 | 0.613 |
P90RSK |
0.760 | -0.046 | -3 | 0.674 |
PKACG |
0.760 | -0.020 | -2 | 0.624 |
KIS |
0.759 | -0.037 | 1 | 0.540 |
BRSK2 |
0.759 | 0.001 | -3 | 0.720 |
LATS2 |
0.759 | -0.046 | -5 | 0.660 |
RSK3 |
0.759 | -0.036 | -3 | 0.670 |
NEK4 |
0.759 | 0.185 | 1 | 0.768 |
SMG1 |
0.759 | -0.026 | 1 | 0.712 |
BRSK1 |
0.759 | 0.001 | -3 | 0.700 |
NEK8 |
0.759 | 0.119 | 2 | 0.771 |
CAMK4 |
0.759 | -0.068 | -3 | 0.732 |
CDK19 |
0.759 | -0.025 | 1 | 0.498 |
GRK1 |
0.758 | -0.064 | -2 | 0.709 |
VRK2 |
0.758 | -0.049 | 1 | 0.742 |
LOK |
0.758 | 0.213 | -2 | 0.704 |
CDK10 |
0.758 | 0.135 | 1 | 0.482 |
MST1 |
0.758 | 0.271 | 1 | 0.763 |
MAPKAPK2 |
0.758 | -0.022 | -3 | 0.626 |
MEK1 |
0.757 | -0.106 | 2 | 0.725 |
MASTL |
0.757 | -0.252 | -2 | 0.736 |
ALK4 |
0.757 | -0.087 | -2 | 0.726 |
PLK1 |
0.757 | -0.083 | -2 | 0.683 |
JNK3 |
0.757 | 0.003 | 1 | 0.499 |
JNK2 |
0.757 | 0.009 | 1 | 0.474 |
TLK2 |
0.757 | -0.016 | 1 | 0.802 |
LATS1 |
0.757 | -0.028 | -3 | 0.755 |
AURB |
0.756 | -0.001 | -2 | 0.535 |
AURC |
0.756 | -0.007 | -2 | 0.544 |
GRK4 |
0.756 | -0.131 | -2 | 0.731 |
SLK |
0.756 | 0.165 | -2 | 0.656 |
TAK1 |
0.755 | 0.216 | 1 | 0.817 |
CDK12 |
0.755 | 0.055 | 1 | 0.477 |
GRK7 |
0.755 | -0.013 | 1 | 0.611 |
MPSK1 |
0.755 | 0.106 | 1 | 0.719 |
CHK1 |
0.755 | -0.019 | -3 | 0.736 |
SSTK |
0.755 | 0.046 | 4 | 0.757 |
ERK1 |
0.754 | -0.009 | 1 | 0.470 |
ERK2 |
0.754 | -0.019 | 1 | 0.507 |
PAK1 |
0.754 | -0.049 | -2 | 0.668 |
TLK1 |
0.754 | -0.020 | -2 | 0.739 |
YSK1 |
0.754 | 0.224 | 2 | 0.781 |
PAK3 |
0.753 | -0.065 | -2 | 0.675 |
P38A |
0.753 | -0.020 | 1 | 0.545 |
SGK3 |
0.753 | 0.015 | -3 | 0.658 |
HIPK1 |
0.753 | 0.024 | 1 | 0.556 |
ERK7 |
0.753 | 0.082 | 2 | 0.561 |
ACVR2A |
0.753 | -0.076 | -2 | 0.693 |
SNRK |
0.753 | -0.078 | 2 | 0.572 |
CDK9 |
0.752 | 0.010 | 1 | 0.505 |
NEK11 |
0.752 | 0.058 | 1 | 0.736 |
DYRK2 |
0.752 | -0.026 | 1 | 0.543 |
CAMK2B |
0.752 | -0.058 | 2 | 0.688 |
PLK3 |
0.752 | -0.069 | 2 | 0.642 |
PKG2 |
0.752 | 0.008 | -2 | 0.566 |
MEKK6 |
0.752 | 0.128 | 1 | 0.750 |
CDK4 |
0.752 | 0.114 | 1 | 0.469 |
CAMKK1 |
0.752 | 0.040 | -2 | 0.705 |
ALK2 |
0.752 | -0.068 | -2 | 0.697 |
MYLK4 |
0.751 | -0.042 | -2 | 0.668 |
SMMLCK |
0.751 | -0.008 | -3 | 0.721 |
PKACB |
0.750 | -0.001 | -2 | 0.557 |
CAMK1G |
0.750 | -0.020 | -3 | 0.676 |
PKN1 |
0.750 | 0.074 | -3 | 0.627 |
ACVR2B |
0.750 | -0.079 | -2 | 0.704 |
MSK2 |
0.750 | -0.070 | -3 | 0.638 |
HIPK3 |
0.750 | 0.012 | 1 | 0.574 |
NEK1 |
0.750 | 0.184 | 1 | 0.730 |
P38G |
0.750 | -0.003 | 1 | 0.391 |
TAO1 |
0.750 | 0.266 | 1 | 0.698 |
LRRK2 |
0.749 | 0.180 | 2 | 0.771 |
CAMK2A |
0.749 | -0.043 | 2 | 0.717 |
CDK18 |
0.749 | -0.021 | 1 | 0.449 |
TGFBR1 |
0.749 | -0.104 | -2 | 0.702 |
PRKX |
0.749 | 0.027 | -3 | 0.597 |
CDK16 |
0.748 | 0.023 | 1 | 0.418 |
GAK |
0.748 | 0.048 | 1 | 0.723 |
MYO3B |
0.747 | 0.292 | 2 | 0.798 |
CDK7 |
0.747 | -0.071 | 1 | 0.531 |
LKB1 |
0.747 | 0.015 | -3 | 0.763 |
HIPK2 |
0.747 | -0.001 | 1 | 0.464 |
RSK4 |
0.747 | -0.028 | -3 | 0.647 |
DCAMKL1 |
0.747 | 0.005 | -3 | 0.692 |
PAK2 |
0.747 | -0.084 | -2 | 0.647 |
MYO3A |
0.747 | 0.305 | 1 | 0.759 |
IRAK1 |
0.747 | -0.079 | -1 | 0.736 |
PRP4 |
0.746 | -0.019 | -3 | 0.676 |
PAK6 |
0.746 | -0.025 | -2 | 0.604 |
MAP3K15 |
0.746 | 0.085 | 1 | 0.697 |
BMPR1A |
0.746 | -0.034 | 1 | 0.593 |
MAPKAPK5 |
0.746 | -0.087 | -3 | 0.625 |
DRAK1 |
0.745 | -0.095 | 1 | 0.575 |
CDK17 |
0.744 | -0.033 | 1 | 0.396 |
CK1E |
0.744 | -0.031 | -3 | 0.518 |
AURA |
0.743 | -0.045 | -2 | 0.505 |
P38B |
0.743 | -0.041 | 1 | 0.468 |
MRCKB |
0.743 | 0.063 | -3 | 0.650 |
CAMKK2 |
0.743 | -0.033 | -2 | 0.709 |
CHK2 |
0.742 | 0.037 | -3 | 0.546 |
DYRK1A |
0.742 | -0.036 | 1 | 0.582 |
MSK1 |
0.742 | -0.061 | -3 | 0.646 |
CDK14 |
0.742 | -0.020 | 1 | 0.500 |
GRK2 |
0.741 | -0.105 | -2 | 0.644 |
CK1G1 |
0.741 | -0.019 | -3 | 0.532 |
AKT3 |
0.741 | 0.048 | -3 | 0.528 |
TTK |
0.741 | 0.090 | -2 | 0.693 |
NEK3 |
0.740 | 0.060 | 1 | 0.711 |
PLK4 |
0.740 | -0.121 | 2 | 0.482 |
TYK2 |
0.740 | 0.107 | 1 | 0.741 |
P38D |
0.739 | -0.022 | 1 | 0.440 |
PDHK3_TYR |
0.739 | 0.002 | 4 | 0.777 |
PDK1 |
0.739 | -0.024 | 1 | 0.692 |
DCAMKL2 |
0.739 | -0.036 | -3 | 0.721 |
DAPK3 |
0.738 | -0.016 | -3 | 0.710 |
TNNI3K_TYR |
0.738 | 0.204 | 1 | 0.710 |
TESK1_TYR |
0.738 | 0.039 | 3 | 0.653 |
MRCKA |
0.738 | 0.041 | -3 | 0.671 |
PINK1_TYR |
0.737 | 0.089 | 1 | 0.695 |
DYRK1B |
0.737 | -0.026 | 1 | 0.502 |
CAMK1D |
0.737 | -0.027 | -3 | 0.608 |
OSR1 |
0.737 | 0.147 | 2 | 0.728 |
TTBK1 |
0.737 | -0.122 | 2 | 0.508 |
DYRK3 |
0.737 | -0.022 | 1 | 0.563 |
PKACA |
0.736 | -0.014 | -2 | 0.520 |
ROS1 |
0.736 | 0.058 | 3 | 0.580 |
P70S6K |
0.736 | -0.049 | -3 | 0.618 |
ROCK2 |
0.735 | 0.044 | -3 | 0.692 |
PDHK4_TYR |
0.735 | -0.013 | 2 | 0.790 |
STK33 |
0.734 | 0.004 | 2 | 0.498 |
HASPIN |
0.734 | 0.084 | -1 | 0.616 |
MAP2K7_TYR |
0.734 | -0.091 | 2 | 0.759 |
RIPK2 |
0.733 | -0.100 | 1 | 0.673 |
MOK |
0.733 | 0.046 | 1 | 0.559 |
RET |
0.732 | -0.007 | 1 | 0.716 |
PASK |
0.732 | -0.106 | -3 | 0.746 |
VRK1 |
0.732 | -0.068 | 2 | 0.748 |
CK1D |
0.732 | -0.047 | -3 | 0.467 |
PBK |
0.732 | 0.028 | 1 | 0.687 |
PDHK1_TYR |
0.732 | -0.042 | -1 | 0.839 |
ROCK1 |
0.731 | 0.063 | -3 | 0.666 |
SGK1 |
0.731 | 0.009 | -3 | 0.522 |
TYRO3 |
0.731 | 0.010 | 3 | 0.607 |
PKMYT1_TYR |
0.731 | -0.085 | 3 | 0.598 |
MAP2K6_TYR |
0.731 | -0.082 | -1 | 0.837 |
FLT3 |
0.731 | 0.066 | 3 | 0.613 |
CSF1R |
0.730 | 0.012 | 3 | 0.564 |
LIMK1_TYR |
0.730 | 0.022 | 2 | 0.777 |
DYRK4 |
0.730 | -0.040 | 1 | 0.469 |
MAP2K4_TYR |
0.730 | -0.123 | -1 | 0.823 |
CAMK1A |
0.730 | -0.013 | -3 | 0.564 |
JAK1 |
0.730 | 0.087 | 1 | 0.713 |
DMPK1 |
0.729 | 0.049 | -3 | 0.670 |
WEE1_TYR |
0.729 | 0.168 | -1 | 0.699 |
MST1R |
0.729 | -0.049 | 3 | 0.569 |
LIMK2_TYR |
0.729 | 0.019 | -3 | 0.792 |
NEK10_TYR |
0.729 | 0.076 | 1 | 0.649 |
MEK2 |
0.728 | -0.098 | 2 | 0.697 |
PLK2 |
0.728 | -0.040 | -3 | 0.822 |
BMPR2_TYR |
0.728 | -0.066 | -1 | 0.793 |
PAK5 |
0.728 | -0.066 | -2 | 0.518 |
LCK |
0.728 | 0.055 | -1 | 0.766 |
JAK2 |
0.727 | -0.049 | 1 | 0.727 |
JNK1 |
0.727 | -0.051 | 1 | 0.446 |
BUB1 |
0.727 | 0.015 | -5 | 0.685 |
CK1A2 |
0.727 | -0.061 | -3 | 0.468 |
DAPK1 |
0.726 | -0.053 | -3 | 0.691 |
CK2A2 |
0.726 | -0.057 | 1 | 0.507 |
MAK |
0.726 | 0.007 | -2 | 0.640 |
PDGFRB |
0.725 | 0.004 | 3 | 0.591 |
INSRR |
0.725 | -0.038 | 3 | 0.538 |
EPHA6 |
0.725 | -0.030 | -1 | 0.802 |
BLK |
0.724 | 0.032 | -1 | 0.776 |
GSK3A |
0.724 | -0.078 | 4 | 0.293 |
HCK |
0.724 | -0.021 | -1 | 0.769 |
GSK3B |
0.724 | -0.101 | 4 | 0.281 |
GRK3 |
0.724 | -0.115 | -2 | 0.596 |
JAK3 |
0.724 | -0.046 | 1 | 0.676 |
SBK |
0.723 | -0.007 | -3 | 0.484 |
FGR |
0.723 | -0.065 | 1 | 0.710 |
BIKE |
0.722 | 0.052 | 1 | 0.633 |
ABL2 |
0.722 | -0.045 | -1 | 0.799 |
ALPHAK3 |
0.722 | -0.016 | -1 | 0.709 |
YES1 |
0.722 | -0.057 | -1 | 0.797 |
ASK1 |
0.721 | 0.013 | 1 | 0.681 |
PDGFRA |
0.721 | -0.010 | 3 | 0.596 |
PKG1 |
0.720 | -0.036 | -2 | 0.495 |
BTK |
0.719 | -0.005 | -1 | 0.736 |
DDR1 |
0.719 | -0.124 | 4 | 0.705 |
KIT |
0.719 | -0.065 | 3 | 0.561 |
TNK1 |
0.718 | -0.024 | 3 | 0.561 |
KDR |
0.718 | -0.056 | 3 | 0.528 |
TEC |
0.718 | -0.011 | -1 | 0.690 |
EPHB4 |
0.718 | -0.109 | -1 | 0.791 |
PAK4 |
0.717 | -0.086 | -2 | 0.522 |
TXK |
0.717 | -0.040 | 1 | 0.643 |
FER |
0.717 | -0.144 | 1 | 0.720 |
ALK |
0.716 | -0.065 | 3 | 0.498 |
CK2A1 |
0.715 | -0.076 | 1 | 0.479 |
ITK |
0.715 | -0.055 | -1 | 0.751 |
ABL1 |
0.715 | -0.081 | -1 | 0.793 |
CRIK |
0.713 | -0.013 | -3 | 0.595 |
TNK2 |
0.713 | -0.099 | 3 | 0.482 |
FRK |
0.713 | -0.018 | -1 | 0.789 |
TEK |
0.712 | -0.137 | 3 | 0.528 |
LYN |
0.711 | -0.057 | 3 | 0.511 |
INSR |
0.710 | -0.090 | 3 | 0.522 |
LTK |
0.710 | -0.097 | 3 | 0.486 |
FGFR2 |
0.710 | -0.160 | 3 | 0.535 |
EPHB1 |
0.710 | -0.147 | 1 | 0.700 |
STLK3 |
0.710 | -0.059 | 1 | 0.688 |
SRMS |
0.709 | -0.156 | 1 | 0.694 |
NTRK2 |
0.709 | -0.119 | 3 | 0.526 |
AXL |
0.709 | -0.133 | 3 | 0.521 |
BMX |
0.708 | -0.063 | -1 | 0.655 |
PTK6 |
0.707 | -0.104 | -1 | 0.702 |
FGFR1 |
0.707 | -0.174 | 3 | 0.523 |
FLT1 |
0.707 | -0.094 | -1 | 0.777 |
EPHB3 |
0.707 | -0.153 | -1 | 0.790 |
MET |
0.706 | -0.143 | 3 | 0.520 |
EPHB2 |
0.705 | -0.142 | -1 | 0.769 |
EPHA4 |
0.705 | -0.139 | 2 | 0.648 |
FYN |
0.705 | -0.068 | -1 | 0.723 |
MATK |
0.704 | -0.067 | -1 | 0.729 |
ERBB2 |
0.704 | -0.141 | 1 | 0.654 |
NTRK1 |
0.703 | -0.174 | -1 | 0.802 |
FLT4 |
0.703 | -0.141 | 3 | 0.511 |
MERTK |
0.702 | -0.159 | 3 | 0.503 |
AAK1 |
0.702 | 0.051 | 1 | 0.543 |
MUSK |
0.702 | -0.013 | 1 | 0.555 |
EPHA1 |
0.702 | -0.124 | 3 | 0.518 |
EPHA7 |
0.700 | -0.131 | 2 | 0.656 |
FGFR3 |
0.700 | -0.167 | 3 | 0.519 |
DDR2 |
0.700 | -0.098 | 3 | 0.503 |
YANK3 |
0.697 | -0.095 | 2 | 0.306 |
SRC |
0.696 | -0.111 | -1 | 0.737 |
EPHA3 |
0.695 | -0.175 | 2 | 0.624 |
NTRK3 |
0.695 | -0.167 | -1 | 0.761 |
EPHA5 |
0.693 | -0.139 | 2 | 0.631 |
CSK |
0.692 | -0.138 | 2 | 0.656 |
EGFR |
0.691 | -0.118 | 1 | 0.549 |
CK1G3 |
0.690 | -0.038 | -3 | 0.355 |
EPHA8 |
0.690 | -0.148 | -1 | 0.757 |
IGF1R |
0.690 | -0.144 | 3 | 0.463 |
CK1A |
0.689 | -0.086 | -3 | 0.394 |
FGFR4 |
0.687 | -0.141 | -1 | 0.723 |
PTK2B |
0.686 | -0.183 | -1 | 0.743 |
SYK |
0.681 | -0.115 | -1 | 0.694 |
ERBB4 |
0.680 | -0.125 | 1 | 0.561 |
PTK2 |
0.679 | -0.120 | -1 | 0.688 |
EPHA2 |
0.677 | -0.169 | -1 | 0.713 |
YANK2 |
0.675 | -0.097 | 2 | 0.329 |
FES |
0.667 | -0.196 | -1 | 0.640 |
CK1G2 |
0.658 | -0.092 | -3 | 0.450 |
ZAP70 |
0.658 | -0.122 | -1 | 0.628 |