Motif 595 (n=44)

Position-wise Probabilities

Download

uniprot	genes	site	source	protein	function
A0A075B6Q4	None	S24	ochoa	Protein LTV1 homolog	Essential for ribosome biogenesis. {ECO:0000256\|ARBA:ARBA00043887}.
A6NKT7	RGPD3	S1033	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
O14715	RGPD8	S1032	ochoa	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	None
O15258	RER1	S95	ochoa	Protein RER1	Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}.
O60216	RAD21	S175	ochoa\|psp	Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]	[Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250\|UniProtKB:Q61550, ECO:0000250\|UniProtKB:Q6TEL1, ECO:0000269\|PubMed:11509732, ECO:0000269\|PubMed:11590136, ECO:0000269\|PubMed:25575569, ECO:0000305\|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269\|PubMed:11875078, ECO:0000269\|PubMed:12417729}.
O75369	FLNB	Y904	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75962	TRIO	S1818	ochoa	Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)	Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250\|UniProtKB:F1M0Z1, ECO:0000269\|PubMed:10341202, ECO:0000269\|PubMed:22155786, ECO:0000269\|PubMed:27418539, ECO:0000269\|PubMed:32109419, ECO:0000269\|PubMed:8643598}.
P00533	EGFR	S1081	ochoa\|psp	Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250\|UniProtKB:Q01279, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11116146, ECO:0000269\|PubMed:11483589, ECO:0000269\|PubMed:11602604, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15374980, ECO:0000269\|PubMed:15590694, ECO:0000269\|PubMed:15611079, ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:19560417, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:21258366, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960, ECO:0000269\|PubMed:35538033, ECO:0000269\|PubMed:7679104, ECO:0000269\|PubMed:8144591, ECO:0000269\|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.
P08651	NFIC	Y299	ochoa	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
P0DJD0	RGPD1	S1017	ochoa	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	None
P0DJD1	RGPD2	S1025	ochoa	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	None
P10586	PTPRF	S1305	ochoa	Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)	Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
P39023	RPL3	S304	ochoa	Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
P49792	RANBP2	S2008	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49810	PSEN2	S327	psp	Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269\|PubMed:10497236, ECO:0000269\|PubMed:10652302, ECO:0000269\|PubMed:16959576, ECO:0000269\|PubMed:21285369}.
P60842	EIF4A1	S205	ochoa	Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269\|PubMed:19153607, ECO:0000269\|PubMed:19204291, ECO:0000269\|PubMed:20156963}.
Q00653	NFKB2	S23	ochoa	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269\|PubMed:7925301}.
Q09666	AHNAK	S4995	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q13435	SF3B2	S362	ochoa	Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
Q5VUJ6	LRCH2	S364	ochoa	Leucine-rich repeat and calponin homology domain-containing protein 2	May play a role in the organization of the cytoskeleton. {ECO:0000250\|UniProtKB:Q960C5, ECO:0000250\|UniProtKB:Q96II8}.
Q6UB99	ANKRD11	S857	ochoa	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250\|UniProtKB:E9Q4F7, ECO:0000269\|PubMed:15184363, ECO:0000269\|PubMed:25556659}.
Q6ZMG9	CERS6	S347	psp	Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)	Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17609214, PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250\|UniProtKB:Q8C172, ECO:0000269\|PubMed:17609214, ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:23530041, ECO:0000269\|PubMed:26887952, ECO:0000269\|PubMed:31916624}.
Q7KZ85	SUPT6H	S1045	ochoa	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269\|PubMed:15060154, ECO:0000269\|PubMed:17234882, ECO:0000269\|PubMed:22316138, ECO:0000269\|PubMed:23503590, ECO:0000269\|PubMed:9514752}.
Q7Z3J3	RGPD4	S1033	ochoa	RanBP2-like and GRIP domain-containing protein 4	None
Q8IX21	SLF2	S710	ochoa	SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)	Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269\|PubMed:25931565, ECO:0000269\|PubMed:36373674}.
Q8N157	AHI1	S328	ochoa	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)	Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250\|UniProtKB:Q8K3E5, ECO:0000269\|PubMed:21623382}.
Q92823	NRCAM	S1251	ochoa	Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)	Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250\|UniProtKB:Q810U4}.
Q92993	KAT5	S199	ochoa\|psp	Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein)	Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250\|UniProtKB:Q8CHK4, ECO:0000269\|PubMed:12776177, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:15042092, ECO:0000269\|PubMed:15121871, ECO:0000269\|PubMed:15310756, ECO:0000269\|PubMed:16141325, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:17189187, ECO:0000269\|PubMed:17360565, ECO:0000269\|PubMed:17709392, ECO:0000269\|PubMed:17996965, ECO:0000269\|PubMed:19783983, ECO:0000269\|PubMed:19909775, ECO:0000269\|PubMed:24463511, ECO:0000269\|PubMed:24835996, ECO:0000269\|PubMed:25865756, ECO:0000269\|PubMed:26291311, ECO:0000269\|PubMed:26438602, ECO:0000269\|PubMed:26829474, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:29040603, ECO:0000269\|PubMed:29174981, ECO:0000269\|PubMed:29192674, ECO:0000269\|PubMed:29335245, ECO:0000269\|PubMed:29765047, ECO:0000269\|PubMed:30409912, ECO:0000269\|PubMed:30704899, ECO:0000269\|PubMed:31857589, ECO:0000269\|PubMed:32034146, ECO:0000269\|PubMed:32817552, ECO:0000269\|PubMed:32822602, ECO:0000269\|PubMed:32832608, ECO:0000269\|PubMed:33076429, ECO:0000269\|PubMed:33938178, ECO:0000269\|PubMed:34077757, ECO:0000269\|PubMed:34608293, ECO:0000269\|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269\|PubMed:37478852}.
Q92997	DVL3	S61	psp	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250\|UniProtKB:Q61062}.
Q96DX4	RSPRY1	S55	ochoa	RING finger and SPRY domain-containing protein 1	None
Q96GA3	LTV1	S200	ochoa	Protein LTV1 homolog	Essential for ribosome biogenesis. {ECO:0000250\|UniProtKB:Q5U3J8}.
Q99666	RGPD5	S1032	ochoa	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	None
Q9BVS4	RIOK2	S385	ochoa	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269\|PubMed:16037817, ECO:0000269\|PubMed:19564402, ECO:0000269\|PubMed:21880710}.
Q9H4G0	EPB41L1	S678	ochoa	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H7C9	AAMDC	S46	ochoa	Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein)	May play a role in preadipocyte differentiation and adipogenesis. {ECO:0000250}.
Q9HCK1	ZDBF2	S539	ochoa	DBF4-type zinc finger-containing protein 2	None
Q9NR09	BIRC6	S473	ochoa	Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)	Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269\|PubMed:14765125, ECO:0000269\|PubMed:15200957, ECO:0000269\|PubMed:18329369, ECO:0000269\|PubMed:36758104, ECO:0000269\|PubMed:36758105, ECO:0000269\|PubMed:36758106}.
Q9NSK0	KLC4	S174	ochoa	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.
Q9ULF5	SLC39A10	S556	ochoa	Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)	Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250\|UniProtKB:Q6P5F6, ECO:0000269\|PubMed:17359283, ECO:0000269\|PubMed:23186163, ECO:0000269\|PubMed:27274087, ECO:0000269\|PubMed:30520657, ECO:0000269\|PubMed:32797246}.
Q9Y657	SPIN1	S196	ochoa	Spindlin-1 (Ovarian cancer-related protein) (Spindlin1)	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250\|UniProtKB:Q61142, ECO:0000269\|PubMed:21960006, ECO:0000269\|PubMed:22258766, ECO:0000269\|PubMed:24589551, ECO:0000269\|PubMed:29061846, ECO:0000269\|PubMed:33574238}.
Q9Y6A5	TACC3	S190	ochoa	Transforming acidic coiled-coil-containing protein 3 (ERIC-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250\|UniProtKB:Q9JJ11, ECO:0000269\|PubMed:14767476, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:23532825}.
Q15084	PDIA6	S169	Sugiyama	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)	May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269\|PubMed:12204115, ECO:0000269\|PubMed:15466936, ECO:0000269\|PubMed:24508390}.
O00469	PLOD2	Y444	Sugiyama	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)	Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250\|UniProtKB:P24802}.
Q02809	PLOD1	Y434	Sugiyama	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)	Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). {ECO:0000250\|UniProtKB:Q9R0E2, ECO:0000269\|PubMed:10686424, ECO:0000269\|PubMed:15854030, ECO:0000269\|PubMed:8621606, ECO:0000305}.

Download

reactome_id	name	p	-log10_p
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	0.000086	4.067
R-HSA-1169408	ISG15 antiviral mechanism	0.001992	2.701
R-HSA-9012852	Signaling by NOTCH3	0.000908	3.042
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.001859	2.731
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptor...	0.001843	2.734
R-HSA-422475	Axon guidance	0.001375	2.862
R-HSA-9675108	Nervous system development	0.001971	2.705
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.002447	2.611
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.014796	1.830
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.017729	1.751
R-HSA-447038	NrCAM interactions	0.020654	1.685
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.023570	1.628
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.023570	1.628
R-HSA-5603029	IkBA variant leads to EDA-ID	0.023570	1.628
R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.026478	1.577
R-HSA-2470946	Cohesin Loading onto Chromatin	0.029377	1.532
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.032268	1.491
R-HSA-201688	WNT mediated activation of DVL	0.035150	1.454
R-HSA-9700645	ALK mutants bind TKIs	0.035150	1.454
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.038024	1.420
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	0.046596	1.332
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	0.004986	2.302
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.052269	1.282
R-HSA-180336	SHC1 events in EGFR signaling	0.055093	1.259
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.055093	1.259
R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.069090	1.161
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.071865	1.143
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.071865	1.143
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.071865	1.143
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.071865	1.143
R-HSA-429947	Deadenylation of mRNA	0.085619	1.067
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	0.088346	1.054
R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.099173	1.004
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.101860	0.992
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.104539	0.981
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.104539	0.981
R-HSA-1855170	IPs transport between nucleus and cytosol	0.109874	0.959
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.109874	0.959
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.005574	2.254
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.112530	0.949
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.117819	0.929
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.128303	0.892
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.130905	0.883
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	0.036025	1.443
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.036680	1.436
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	0.039348	1.405
R-HSA-72165	mRNA Splicing - Minor Pathway	0.148907	0.827
R-HSA-192823	Viral mRNA Translation	0.045612	1.341
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	0.049240	1.308
R-HSA-1643713	Signaling by EGFR in Cancer	0.091064	1.041
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.074632	1.127
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.074632	1.127
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.063516	1.197
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.063516	1.197
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.066307	1.178
R-HSA-182971	EGFR downregulation	0.104539	0.981
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.052971	1.276
R-HSA-180292	GAB1 signalosome	0.066307	1.178
R-HSA-156902	Peptide chain elongation	0.034086	1.467
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.052971	1.276
R-HSA-9948299	Ribosome-associated quality control	0.078151	1.107
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	0.146358	0.835
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.085619	1.067
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.099173	1.004
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	0.040027	1.398
R-HSA-179812	GRB2 events in EGFR signaling	0.046596	1.332
R-HSA-9664420	Killing mechanisms	0.057909	1.237
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	0.057909	1.237
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.101860	0.992
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.109874	0.959
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.005574	2.254
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	0.133500	0.875
R-HSA-72613	Eukaryotic Translation Initiation	0.006941	2.159
R-HSA-5693537	Resolution of D-Loop Structures	0.112530	0.949
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.061517	1.211
R-HSA-72737	Cap-dependent Translation Initiation	0.006941	2.159
R-HSA-72764	Eukaryotic Translation Termination	0.040027	1.398
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.109874	0.959
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.101860	0.992
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.093775	1.028
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.115178	0.939
R-HSA-9017802	Noncanonical activation of NOTCH3	0.023570	1.628
R-HSA-2179392	EGFR Transactivation by Gastrin	0.038024	1.420
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.043747	1.359
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.055093	1.259
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.060716	1.217
R-HSA-73980	RNA Polymerase III Transcription Termination	0.066307	1.178
R-HSA-933542	TRAF6 mediated NF-kB activation	0.085619	1.067
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.115178	0.939
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.123076	0.910
R-HSA-72689	Formation of a pool of free 40S subunits	0.040027	1.398
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.146358	0.835
R-HSA-9609690	HCMV Early Events	0.134710	0.871
R-HSA-156842	Eukaryotic Translation Elongation	0.037340	1.428
R-HSA-1963642	PI3K events in ERBB2 signaling	0.063516	1.197
R-HSA-4641258	Degradation of DVL	0.123076	0.910
R-HSA-418885	DCC mediated attractive signaling	0.055093	1.259
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.112530	0.949
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.125693	0.901
R-HSA-68877	Mitotic Prometaphase	0.131694	0.880
R-HSA-2467813	Separation of Sister Chromatids	0.102529	0.989
R-HSA-9839383	TGFBR3 PTM regulation	0.032268	1.491
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.043747	1.359
R-HSA-388844	Receptor-type tyrosine-protein phosphatases	0.057909	1.237
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.069090	1.161
R-HSA-8863795	Downregulation of ERBB2 signaling	0.101860	0.992
R-HSA-180746	Nuclear import of Rev protein	0.115178	0.939
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.117819	0.929
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.133500	0.875
R-HSA-2408557	Selenocysteine synthesis	0.044190	1.355
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.014969	1.825
R-HSA-445095	Interaction between L1 and Ankyrins	0.093775	1.028
R-HSA-399719	Trafficking of AMPA receptors	0.104539	0.981
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.023935	1.621
R-HSA-177243	Interactions of Rev with host cellular proteins	0.130905	0.883
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.130905	0.883
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.133500	0.875
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	0.046329	1.334
R-HSA-201681	TCF dependent signaling in response to WNT	0.121763	0.914
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.020654	1.685
R-HSA-448706	Interleukin-1 processing	0.035150	1.454
R-HSA-9013700	NOTCH4 Activation and Transmission of Signal to the Nucleus	0.035150	1.454
R-HSA-193692	Regulated proteolysis of p75NTR	0.035150	1.454
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.125693	0.901
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.148907	0.827
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.066307	1.178
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.035150	1.454
R-HSA-77387	Insulin receptor recycling	0.096478	1.016
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.128303	0.892
R-HSA-9604323	Negative regulation of NOTCH4 signaling	0.130905	0.883
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.049978	1.301
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.075208	1.124
R-HSA-8953854	Metabolism of RNA	0.012970	1.887
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.074632	1.127
R-HSA-6794362	Protein-protein interactions at synapses	0.031568	1.501
R-HSA-373752	Netrin-1 signaling	0.143801	0.842
R-HSA-9675135	Diseases of DNA repair	0.148907	0.827
R-HSA-447043	Neurofascin interactions	0.026478	1.577
R-HSA-205043	NRIF signals cell death from the nucleus	0.052269	1.282
R-HSA-193648	NRAGE signals death through JNK	0.015785	1.802
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.091064	1.041
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	0.104539	0.981
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.130905	0.883
R-HSA-5260271	Diseases of Immune System	0.130905	0.883
R-HSA-9711097	Cellular response to starvation	0.096942	1.013
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.003386	2.470
R-HSA-373760	L1CAM interactions	0.057576	1.240
R-HSA-8849932	Synaptic adhesion-like molecules	0.066307	1.178
R-HSA-168255	Influenza Infection	0.021316	1.671
R-HSA-416476	G alpha (q) signalling events	0.052762	1.278
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	0.109874	0.959
R-HSA-9013694	Signaling by NOTCH4	0.025052	1.601
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.091448	1.039
R-HSA-445144	Signal transduction by L1	0.071865	1.143
R-HSA-1980145	Signaling by NOTCH2	0.115178	0.939
R-HSA-72312	rRNA processing	0.006748	2.171
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	0.148907	0.827
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	0.148907	0.827
R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.082884	1.082
R-HSA-435354	Zinc transporters	0.052269	1.282
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.120451	0.919
R-HSA-3928662	EPHB-mediated forward signaling	0.143801	0.842
R-HSA-9733709	Cardiogenesis	0.109874	0.959
R-HSA-157118	Signaling by NOTCH	0.042512	1.371
R-HSA-416482	G alpha (12/13) signalling events	0.027350	1.563
R-HSA-8939211	ESR-mediated signaling	0.041310	1.384
R-HSA-9018519	Estrogen-dependent gene expression	0.076429	1.117
R-HSA-2408522	Selenoamino acid metabolism	0.102529	0.989
R-HSA-193704	p75 NTR receptor-mediated signalling	0.004383	2.358
R-HSA-844456	The NLRP3 inflammasome	0.069090	1.161
R-HSA-2682334	EPH-Ephrin signaling	0.037340	1.428
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.010659	1.972
R-HSA-3214841	PKMTs methylate histone lysines	0.133500	0.875
R-HSA-9839373	Signaling by TGFBR3	0.148907	0.827
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.014741	1.831
R-HSA-9700206	Signaling by ALK in cancer	0.049240	1.308
R-HSA-74158	RNA Polymerase III Transcription	0.120451	0.919
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.021764	1.662
R-HSA-1236394	Signaling by ERBB4	0.025052	1.601
R-HSA-9006931	Signaling by Nuclear Receptors	0.105937	0.975
R-HSA-622312	Inflammasomes	0.096478	1.016
R-HSA-376176	Signaling by ROBO receptors	0.141808	0.848
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.049240	1.308
R-HSA-1251985	Nuclear signaling by ERBB4	0.130905	0.883
R-HSA-1266738	Developmental Biology	0.062018	1.207
R-HSA-1474290	Collagen formation	0.038674	1.413
R-HSA-73887	Death Receptor Signaling	0.014741	1.831
R-HSA-913531	Interferon Signaling	0.119208	0.924
R-HSA-2262752	Cellular responses to stress	0.087146	1.060
R-HSA-381038	XBP1(S) activates chaperone genes	0.032817	1.484
R-HSA-8953897	Cellular responses to stimuli	0.131536	0.881
R-HSA-381070	IRE1alpha activates chaperones	0.036680	1.436
R-HSA-381119	Unfolded Protein Response (UPR)	0.079017	1.102
R-HSA-72766	Translation	0.150285	0.823
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	0.151449	0.820
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.151449	0.820
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.153983	0.813
R-HSA-425410	Metal ion SLC transporters	0.153983	0.813
R-HSA-68882	Mitotic Anaphase	0.156239	0.806
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.157280	0.803
R-HSA-112382	Formation of RNA Pol II elongation complex	0.164047	0.785
R-HSA-6794361	Neurexins and neuroligins	0.164047	0.785
R-HSA-1221632	Meiotic synapsis	0.166544	0.778
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.166544	0.778
R-HSA-72649	Translation initiation complex formation	0.169034	0.772
R-HSA-72702	Ribosomal scanning and start codon recognition	0.173993	0.759
R-HSA-177929	Signaling by EGFR	0.173993	0.759
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.173993	0.759
R-HSA-3247509	Chromatin modifying enzymes	0.175188	0.756
R-HSA-2980766	Nuclear Envelope Breakdown	0.176461	0.753
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	0.178923	0.747
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.178923	0.747
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.181376	0.741
R-HSA-429914	Deadenylation-dependent mRNA decay	0.181376	0.741
R-HSA-194441	Metabolism of non-coding RNA	0.181376	0.741
R-HSA-191859	snRNP Assembly	0.181376	0.741
R-HSA-1227986	Signaling by ERBB2	0.183823	0.736
R-HSA-983189	Kinesins	0.183823	0.736
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.183823	0.736
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.183823	0.736
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.183823	0.736
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.183823	0.736
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.183823	0.736
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.183823	0.736
R-HSA-168325	Viral Messenger RNA Synthesis	0.186263	0.730
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.188695	0.724
R-HSA-6784531	tRNA processing in the nucleus	0.188695	0.724
R-HSA-8848021	Signaling by PTK6	0.191121	0.719
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.191121	0.719
R-HSA-4839726	Chromatin organization	0.191255	0.718
R-HSA-9609646	HCMV Infection	0.192334	0.716
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.193539	0.713
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.198354	0.703
R-HSA-5693606	DNA Double Strand Break Response	0.200751	0.697
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.200751	0.697
R-HSA-69620	Cell Cycle Checkpoints	0.200994	0.697
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.203141	0.692
R-HSA-9734767	Developmental Cell Lineages	0.206431	0.685
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.207900	0.682
R-HSA-5578749	Transcriptional regulation by small RNAs	0.212632	0.672
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.214987	0.668
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.217335	0.663
R-HSA-69473	G2/M DNA damage checkpoint	0.217335	0.663
R-HSA-1980143	Signaling by NOTCH1	0.222011	0.654
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.223936	0.650
R-HSA-9658195	Leishmania infection	0.226134	0.646
R-HSA-9824443	Parasitic Infection Pathways	0.226134	0.646
R-HSA-4086400	PCP/CE pathway	0.226660	0.645
R-HSA-9659379	Sensory processing of sound	0.228974	0.640
R-HSA-5693607	Processing of DNA double-strand break ends	0.233582	0.632
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.235876	0.627
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.238163	0.623
R-HSA-1500620	Meiosis	0.242718	0.615
R-HSA-5687128	MAPK6/MAPK4 signaling	0.242718	0.615
R-HSA-195721	Signaling by WNT	0.244878	0.611
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.244985	0.611
R-HSA-141424	Amplification of signal from the kinetochores	0.244985	0.611
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.247245	0.607
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.256221	0.591
R-HSA-74752	Signaling by Insulin receptor	0.262884	0.580
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.267293	0.573
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.269488	0.569
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.273859	0.562
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.273859	0.562
R-HSA-8957275	Post-translational protein phosphorylation	0.278204	0.556
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.278204	0.556
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.278204	0.556
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.278204	0.556
R-HSA-3214847	HATs acetylate histones	0.280367	0.552
R-HSA-1474244	Extracellular matrix organization	0.281429	0.551
R-HSA-69618	Mitotic Spindle Checkpoint	0.282524	0.549
R-HSA-70171	Glycolysis	0.282524	0.549
R-HSA-9009391	Extra-nuclear estrogen signaling	0.284674	0.546
R-HSA-9020702	Interleukin-1 signaling	0.284674	0.546
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.286818	0.542
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.291087	0.536
R-HSA-162582	Signal Transduction	0.292036	0.535
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.292894	0.533
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.295332	0.530
R-HSA-5683057	MAPK family signaling cascades	0.299142	0.524
R-HSA-211000	Gene Silencing by RNA	0.299551	0.524
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.301651	0.520
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.303746	0.517
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.303746	0.517
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.305834	0.515
R-HSA-166166	MyD88-independent TLR4 cascade	0.305834	0.515
R-HSA-1483249	Inositol phosphate metabolism	0.309991	0.509
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.312061	0.506
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.314125	0.503
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.316182	0.500
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.318234	0.497
R-HSA-70326	Glucose metabolism	0.324352	0.489
R-HSA-5693538	Homology Directed Repair	0.326380	0.486
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.326380	0.486
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.328401	0.484
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.328401	0.484
R-HSA-68875	Mitotic Prophase	0.330417	0.481
R-HSA-3371556	Cellular response to heat stress	0.332426	0.478
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.334430	0.476
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.334430	0.476
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.336428	0.473
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.336428	0.473
R-HSA-2132295	MHC class II antigen presentation	0.336428	0.473
R-HSA-162909	Host Interactions of HIV factors	0.338420	0.471
R-HSA-68886	M Phase	0.338741	0.470
R-HSA-69481	G2/M Checkpoints	0.346330	0.461
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.352201	0.453
R-HSA-1474165	Reproduction	0.354147	0.451
R-HSA-8856688	Golgi-to-ER retrograde transport	0.358021	0.446
R-HSA-3858494	Beta-catenin independent WNT signaling	0.367607	0.435
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.369507	0.432
R-HSA-1640170	Cell Cycle	0.371086	0.431
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.380793	0.419
R-HSA-162599	Late Phase of HIV Life Cycle	0.380793	0.419
R-HSA-8856828	Clathrin-mediated endocytosis	0.382654	0.417
R-HSA-69242	S Phase	0.391880	0.407
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.391880	0.407
R-HSA-446652	Interleukin-1 family signaling	0.399163	0.399
R-HSA-5693532	DNA Double-Strand Break Repair	0.400970	0.397
R-HSA-5663205	Infectious disease	0.402997	0.395
R-HSA-9610379	HCMV Late Events	0.408147	0.389
R-HSA-162587	HIV Life Cycle	0.408147	0.389
R-HSA-5633007	Regulation of TP53 Activity	0.413474	0.384
R-HSA-9006936	Signaling by TGFB family members	0.413474	0.384
R-HSA-1280215	Cytokine Signaling in Immune system	0.413705	0.383
R-HSA-388396	GPCR downstream signalling	0.424805	0.372
R-HSA-5619102	SLC transporter disorders	0.425722	0.371
R-HSA-112316	Neuronal System	0.430280	0.366
R-HSA-72306	tRNA processing	0.432608	0.364
R-HSA-5621481	C-type lectin receptors (CLRs)	0.434317	0.362
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.436021	0.360
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.441102	0.355
R-HSA-2559583	Cellular Senescence	0.449472	0.347
R-HSA-9824446	Viral Infection Pathways	0.449813	0.347
R-HSA-5617833	Cilium Assembly	0.465844	0.332
R-HSA-168898	Toll-like Receptor Cascades	0.467455	0.330
R-HSA-72163	mRNA Splicing - Major Pathway	0.472259	0.326
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.481740	0.317
R-HSA-389948	Co-inhibition by PD-1	0.481740	0.317
R-HSA-428157	Sphingolipid metabolism	0.483303	0.316
R-HSA-1643685	Disease	0.484607	0.315
R-HSA-72172	mRNA Splicing	0.489513	0.310
R-HSA-372790	Signaling by GPCR	0.490191	0.310
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.501713	0.300
R-HSA-162906	HIV Infection	0.523823	0.281
R-HSA-9705683	SARS-CoV-2-host interactions	0.525262	0.280
R-HSA-69278	Cell Cycle, Mitotic	0.526276	0.279
R-HSA-5619115	Disorders of transmembrane transporters	0.551815	0.258
R-HSA-74160	Gene expression (Transcription)	0.553358	0.257
R-HSA-388841	Regulation of T cell activation by CD28 family	0.563879	0.249
R-HSA-71291	Metabolism of amino acids and derivatives	0.572791	0.242
R-HSA-199991	Membrane Trafficking	0.598138	0.223
R-HSA-392499	Metabolism of proteins	0.600648	0.221
R-HSA-5673001	RAF/MAP kinase cascade	0.605455	0.218
R-HSA-1257604	PIP3 activates AKT signaling	0.612586	0.213
R-HSA-5684996	MAPK1/MAPK3 signaling	0.613762	0.212
R-HSA-1852241	Organelle biogenesis and maintenance	0.640962	0.193
R-HSA-112315	Transmission across Chemical Synapses	0.644228	0.191
R-HSA-9006925	Intracellular signaling by second messengers	0.664243	0.178
R-HSA-9694516	SARS-CoV-2 Infection	0.671335	0.173
R-HSA-73894	DNA Repair	0.682185	0.166
R-HSA-5653656	Vesicle-mediated transport	0.714807	0.146
R-HSA-425407	SLC-mediated transmembrane transport	0.717036	0.144
R-HSA-597592	Post-translational protein modification	0.751475	0.124
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.763134	0.117
R-HSA-73857	RNA Polymerase II Transcription	0.766211	0.116
R-HSA-3700989	Transcriptional Regulation by TP53	0.770301	0.113
R-HSA-9679506	SARS-CoV Infections	0.825949	0.083
R-HSA-1280218	Adaptive Immune System	0.835982	0.078
R-HSA-449147	Signaling by Interleukins	0.859885	0.066
R-HSA-212436	Generic Transcription Pathway	0.860236	0.065
R-HSA-109582	Hemostasis	0.914702	0.039
R-HSA-168256	Immune System	0.936084	0.029
R-HSA-382551	Transport of small molecules	0.954212	0.020
R-HSA-9709957	Sensory Perception	0.979848	0.009
R-HSA-168249	Innate Immune System	0.985047	0.007
R-HSA-556833	Metabolism of lipids	0.991111	0.004
R-HSA-1430728	Metabolism	0.998277	0.001

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
BMPR1B	0.668	0.320	1	0.594
CK2A2	0.666	0.312	1	0.688
BMPR1A	0.665	0.336	1	0.583
FAM20C	0.663	0.088	2	0.321
TGFBR1	0.663	0.370	-2	0.759
COT	0.660	0.102	2	0.377
GRK4	0.659	0.161	-2	0.561
ALK2	0.658	0.380	-2	0.742
CK2A1	0.658	0.281	1	0.677
CAMK2G	0.657	0.260	2	0.562
GRK1	0.656	0.120	-2	0.489
MOS	0.655	0.199	1	0.707
GRK6	0.655	0.169	1	0.625
ACVR2A	0.654	0.281	-2	0.693
ACVR2B	0.654	0.289	-2	0.690
CAMK2B	0.653	0.220	2	0.569
KIS	0.651	0.064	1	0.544
ALK4	0.651	0.327	-2	0.741
CDC7	0.649	0.056	1	0.677
GRK7	0.648	0.113	1	0.558
GRK3	0.647	0.100	-2	0.525
NDR2	0.647	0.075	-3	0.587
TGFBR2	0.647	0.172	-2	0.718
CK1E	0.647	0.122	-3	0.739
IKKB	0.647	0.006	-2	0.411
DSTYK	0.645	0.100	2	0.404
CLK3	0.645	0.083	1	0.597
PLK2	0.645	0.160	-3	0.682
IKKA	0.645	0.039	-2	0.442
PLK3	0.644	0.136	2	0.440
GRK5	0.644	0.068	-3	0.685
GCN2	0.644	0.050	2	0.426
CAMK2A	0.644	0.222	2	0.603
CK1D	0.644	0.148	-3	0.710
PLK1	0.644	0.110	-2	0.601
ATM	0.642	0.105	1	0.550
IKKE	0.641	-0.013	1	0.603
GRK2	0.641	0.074	-2	0.522
BCKDK	0.640	0.008	-1	0.500
BMPR2	0.640	0.180	-2	0.586
TBK1	0.640	-0.031	1	0.601
PRPK	0.640	-0.027	-1	0.465
TLK2	0.639	0.143	1	0.614
CK1A2	0.639	0.129	-3	0.715
TLK1	0.638	0.247	-2	0.659
CK1G1	0.638	0.093	-3	0.715
PDHK4	0.636	-0.048	1	0.678
MTOR	0.636	-0.082	1	0.648
PDHK1	0.635	0.001	1	0.672
LATS2	0.635	0.096	-5	0.539
RAF1	0.635	-0.021	1	0.651
NEK6	0.634	0.025	-2	0.611
NEK7	0.634	-0.009	-3	0.598
CAMK1B	0.632	-0.020	-3	0.617
ATR	0.631	-0.032	1	0.614
PIM3	0.630	-0.042	-3	0.594
CAMK2D	0.630	0.100	-3	0.557
ULK2	0.628	-0.126	2	0.349
TTBK2	0.628	-0.097	2	0.305
PRKX	0.627	0.045	-3	0.494
RSK2	0.627	-0.022	-3	0.516
DNAPK	0.626	0.094	1	0.544
ULK1	0.626	-0.097	-3	0.608
ANKRD3	0.626	0.048	1	0.633
MLK1	0.625	-0.084	2	0.334
NDR1	0.625	-0.039	-3	0.581
DLK	0.625	-0.029	1	0.651
AURA	0.625	-0.012	-2	0.313
PKN3	0.623	-0.051	-3	0.580
ERK5	0.623	-0.071	1	0.616
SRPK1	0.623	-0.006	-3	0.509
NLK	0.622	-0.102	1	0.644
CK1A	0.622	0.107	-3	0.673
LATS1	0.622	0.079	-3	0.572
SKMLCK	0.621	-0.077	-2	0.462
CDKL1	0.621	-0.052	-3	0.547
PIM1	0.621	-0.002	-3	0.577
MST4	0.621	-0.076	2	0.348
SRPK3	0.621	0.005	-3	0.505
MEKK3	0.620	0.010	1	0.626
MLK4	0.620	-0.027	2	0.304
P90RSK	0.620	-0.051	-3	0.522
CDK1	0.620	0.024	1	0.493
MSK1	0.620	0.004	-3	0.492
MAPKAPK2	0.619	0.021	-3	0.481
PRKD1	0.619	-0.038	-3	0.516
MEK1	0.619	0.001	2	0.414
RSK4	0.619	-0.022	-3	0.514
SRPK2	0.618	0.002	-3	0.455
HUNK	0.618	-0.137	2	0.373
DAPK2	0.618	-0.063	-3	0.605
PLK4	0.618	-0.086	2	0.324
PKACG	0.618	-0.061	-2	0.392
CDK8	0.618	-0.022	1	0.537
NUAK2	0.617	-0.075	-3	0.620
MSK2	0.617	-0.023	-3	0.491
MASTL	0.617	-0.168	-2	0.453
NIK	0.617	-0.126	-3	0.636
MARK4	0.617	-0.084	4	0.705
CDKL5	0.616	-0.052	-3	0.526
PKACB	0.616	-0.012	-2	0.343
YSK4	0.616	-0.027	1	0.627
RIPK3	0.616	-0.147	3	0.619
CLK2	0.616	0.022	-3	0.545
ICK	0.616	-0.045	-3	0.570
CAMLCK	0.615	-0.086	-2	0.451
TSSK2	0.615	-0.061	-5	0.648
PASK	0.614	0.067	-3	0.609
P70S6KB	0.614	-0.055	-3	0.554
CHAK2	0.614	-0.138	-1	0.423
PRKD2	0.614	-0.040	-3	0.511
PKN2	0.614	-0.101	-3	0.600
RSK3	0.614	-0.071	-3	0.507
HIPK4	0.613	-0.073	1	0.607
AMPKA1	0.613	-0.087	-3	0.606
CK1G2	0.612	0.131	-3	0.691
BRAF	0.612	0.100	-4	0.658
WNK1	0.612	-0.117	-2	0.456
CLK4	0.612	-0.017	-3	0.562
NEK9	0.612	-0.154	2	0.352
JNK3	0.612	0.002	1	0.524
AURC	0.612	-0.059	-2	0.328
CK1G3	0.612	0.128	-3	0.649
WNK3	0.611	-0.204	1	0.616
PKCD	0.611	-0.098	2	0.332
MLK3	0.610	-0.091	2	0.295
CHK1	0.610	0.017	-3	0.557
ZAK	0.610	-0.028	1	0.633
CAMK4	0.610	-0.090	-3	0.597
GSK3A	0.609	0.030	4	0.375
BRSK1	0.609	-0.052	-3	0.541
PTK2	0.609	0.198	-1	0.646
TSSK1	0.609	-0.084	-3	0.612
P38B	0.608	0.001	1	0.504
MEKK2	0.608	-0.044	2	0.355
P38G	0.607	-0.004	1	0.434
SMG1	0.607	-0.074	1	0.575
CDK19	0.607	-0.038	1	0.502
TTBK1	0.607	-0.103	2	0.275
DYRK2	0.607	-0.038	1	0.546
JNK2	0.607	-0.007	1	0.500
RIPK1	0.606	-0.200	1	0.581
MEKK1	0.605	-0.036	1	0.623
PDHK1_TYR	0.604	0.239	-1	0.531
PERK	0.604	-0.023	-2	0.612
HRI	0.604	-0.019	-2	0.596
MAP2K6_TYR	0.604	0.242	-1	0.521
IRE1	0.604	-0.164	1	0.554
AMPKA2	0.604	-0.090	-3	0.576
PRP4	0.604	-0.021	-3	0.569
P38A	0.604	-0.030	1	0.546
AURB	0.603	-0.072	-2	0.324
VRK2	0.603	-0.225	1	0.655
PKR	0.603	-0.104	1	0.600
PAK1	0.603	-0.113	-2	0.363
DRAK1	0.603	-0.092	1	0.567
YANK3	0.603	-0.002	2	0.189
FLT1	0.603	0.234	-1	0.627
MYLK4	0.603	-0.072	-2	0.370
MAPKAPK3	0.602	-0.087	-3	0.499
DCAMKL1	0.602	-0.040	-3	0.556
IRE2	0.602	-0.105	2	0.295
PDHK3_TYR	0.602	0.215	4	0.761
DYRK4	0.602	-0.008	1	0.498
CLK1	0.602	-0.039	-3	0.525
PKACA	0.601	-0.031	-2	0.308
P38D	0.601	0.002	1	0.442
TAO3	0.601	-0.042	1	0.627
BMPR2_TYR	0.601	0.153	-1	0.552
MLK2	0.601	-0.195	2	0.351
NUAK1	0.601	-0.091	-3	0.555
PDHK4_TYR	0.601	0.179	2	0.460
NIM1	0.601	-0.175	3	0.615
MARK2	0.600	-0.073	4	0.613
CDK13	0.600	-0.043	1	0.507
PAK6	0.600	-0.088	-2	0.284
QSK	0.600	-0.088	4	0.679
PHKG1	0.600	-0.105	-3	0.583
ERK1	0.600	-0.033	1	0.496
PKG2	0.600	-0.085	-2	0.344
PKCG	0.599	-0.133	2	0.281
DCAMKL2	0.599	-0.052	-3	0.574
MEK5	0.599	-0.164	2	0.373
CDK5	0.598	-0.036	1	0.526
CDK18	0.598	-0.028	1	0.460
MAP2K4_TYR	0.598	0.196	-1	0.514
CDK17	0.598	-0.019	1	0.430
CDK7	0.598	-0.053	1	0.533
HIPK2	0.598	-0.028	1	0.482
GSK3B	0.598	-0.013	4	0.373
JNK1	0.598	0.002	1	0.485
MARK3	0.598	-0.078	4	0.644
PAK2	0.598	-0.131	-2	0.352
EPHA6	0.598	0.161	-1	0.584
AKT2	0.598	-0.057	-3	0.478
SYK	0.597	0.155	-1	0.592
MNK1	0.597	-0.110	-2	0.404
PKCB	0.597	-0.128	2	0.278
MNK2	0.597	-0.122	-2	0.393
SIK	0.596	-0.083	-3	0.533
PKCH	0.596	-0.141	2	0.277
TTK	0.596	0.118	-2	0.640
CDK2	0.596	-0.039	1	0.545
ERK2	0.596	-0.050	1	0.522
PAK3	0.596	-0.157	-2	0.346
BRSK2	0.596	-0.112	-3	0.553
CDK3	0.595	-0.006	1	0.441
PRKD3	0.595	-0.083	-3	0.490
EGFR	0.595	0.108	1	0.525
SSTK	0.594	-0.074	4	0.682
HIPK1	0.594	-0.050	1	0.551
PKCA	0.594	-0.137	2	0.273
INSRR	0.594	0.145	3	0.607
SGK3	0.594	-0.096	-3	0.501
MARK1	0.594	-0.092	4	0.665
DAPK3	0.594	-0.022	-3	0.577
CAMK1G	0.594	-0.081	-3	0.537
MST2	0.594	0.028	1	0.623
DAPK1	0.593	-0.029	-3	0.572
CDK12	0.593	-0.049	1	0.491
EPHA4	0.593	0.130	2	0.426
EEF2K	0.593	-0.012	3	0.664
GAK	0.593	-0.043	1	0.578
MAPKAPK5	0.593	-0.098	-3	0.453
MST3	0.592	-0.115	2	0.323
SNRK	0.592	-0.179	2	0.324
SMMLCK	0.592	-0.060	-3	0.562
QIK	0.592	-0.172	-3	0.575
FGFR3	0.592	0.125	3	0.650
FGFR2	0.592	0.119	3	0.668
EPHA5	0.591	0.172	2	0.432
NEK5	0.591	-0.136	1	0.592
FGFR4	0.591	0.104	-1	0.529
JAK3	0.590	0.134	1	0.628
TXK	0.590	0.081	1	0.656
DYRK1A	0.589	-0.060	1	0.572
EPHB4	0.589	0.096	-1	0.564
CHAK1	0.589	-0.223	2	0.303
CAMK1D	0.589	-0.029	-3	0.458
PINK1	0.589	-0.131	1	0.618
NEK2	0.589	-0.208	2	0.331
PAK4	0.589	-0.091	-2	0.266
EPHB2	0.589	0.131	-1	0.565
NEK11	0.589	-0.170	1	0.630
TAK1	0.588	-0.006	1	0.653
EPHB1	0.588	0.111	1	0.632
MAP2K7_TYR	0.588	-0.048	2	0.438
PIM2	0.588	-0.075	-3	0.508
NEK8	0.587	-0.126	2	0.336
PHKG2	0.587	-0.118	-3	0.576
MELK	0.587	-0.152	-3	0.543
CDK16	0.587	-0.023	1	0.437
EPHA3	0.586	0.111	2	0.418
KIT	0.586	0.056	3	0.649
PKCZ	0.586	-0.181	2	0.300
WNK4	0.586	-0.180	-2	0.462
ERK7	0.586	-0.068	2	0.190
FER	0.586	0.033	1	0.631
TAO2	0.585	-0.116	2	0.362
TESK1_TYR	0.585	-0.047	3	0.694
EPHA2	0.585	0.151	-1	0.574
DYRK1B	0.585	-0.045	1	0.487
AKT1	0.585	-0.068	-3	0.483
GCK	0.585	-0.064	1	0.625
DYRK3	0.585	-0.061	1	0.556
EPHB3	0.584	0.087	-1	0.552
SRMS	0.584	0.043	1	0.627
EPHA7	0.584	0.081	2	0.404
PDK1	0.584	-0.120	1	0.592
EPHA8	0.584	0.086	-1	0.533
ERBB4	0.584	0.092	1	0.524
PAK5	0.583	-0.110	-2	0.253
MET	0.583	0.056	3	0.638
RET	0.582	-0.038	1	0.614
ERBB2	0.582	0.050	1	0.587
IRAK1	0.582	-0.211	-1	0.365
KDR	0.582	0.053	3	0.609
FGFR1	0.582	0.059	3	0.640
FGR	0.581	-0.013	1	0.604
DDR1	0.581	-0.024	4	0.745
P70S6K	0.581	-0.094	-3	0.459
CDK9	0.581	-0.083	1	0.506
AKT3	0.580	-0.051	-3	0.413
PINK1_TYR	0.580	-0.122	1	0.649
ALPHAK3	0.580	0.025	-1	0.485
SBK	0.580	-0.003	-3	0.374
CDK14	0.580	-0.064	1	0.490
OSR1	0.580	-0.000	2	0.336
FLT4	0.580	0.068	3	0.607
SGK1	0.580	-0.053	-3	0.403
CAMKK1	0.580	-0.141	-2	0.373
YANK2	0.579	-0.001	2	0.197
HIPK3	0.579	-0.086	1	0.552
CSF1R	0.579	-0.027	3	0.629
IRAK4	0.579	-0.222	1	0.543
FYN	0.578	0.011	-1	0.470
PKCT	0.578	-0.157	2	0.284
NTRK1	0.578	0.040	-1	0.545
IGF1R	0.578	0.073	3	0.542
MST1R	0.577	-0.034	3	0.658
MAK	0.577	-0.029	-2	0.391
CDK10	0.577	-0.052	1	0.475
MPSK1	0.577	-0.136	1	0.568
BLK	0.577	0.027	-1	0.475
MINK	0.577	-0.110	1	0.616
MST1	0.576	-0.065	1	0.611
YES1	0.576	-0.047	-1	0.460
STK33	0.576	-0.150	2	0.275
MAP3K15	0.576	-0.179	1	0.621
INSR	0.576	0.044	3	0.586
JAK2	0.575	-0.060	1	0.617
DMPK1	0.575	-0.018	-3	0.548
NTRK3	0.575	0.030	-1	0.517
TYK2	0.575	-0.097	1	0.609
PKMYT1_TYR	0.575	-0.172	3	0.685
ZAP70	0.575	0.056	-1	0.479
PDGFRB	0.574	-0.027	3	0.649
CAMKK2	0.574	-0.125	-2	0.361
PKCE	0.574	-0.118	2	0.263
TNIK	0.574	-0.104	3	0.647
RIPK2	0.574	-0.166	1	0.606
HGK	0.574	-0.123	3	0.653
HPK1	0.574	-0.114	1	0.613
MRCKA	0.574	-0.064	-3	0.519
LKB1	0.573	-0.152	-3	0.580
FLT3	0.573	-0.029	3	0.613
ABL2	0.573	-0.038	-1	0.459
MEK2	0.573	-0.150	2	0.386
MRCKB	0.573	-0.079	-3	0.509
HCK	0.572	-0.052	-1	0.471
CSK	0.572	-0.017	2	0.408
LCK	0.571	-0.018	-1	0.478
KHS2	0.571	-0.079	1	0.618
SLK	0.571	-0.128	-2	0.376
MERTK	0.571	-0.065	3	0.606
CHK2	0.571	-0.072	-3	0.431
NTRK2	0.570	0.017	3	0.621
LRRK2	0.570	-0.202	2	0.371
ROS1	0.570	-0.109	3	0.594
TYRO3	0.570	-0.130	3	0.617
LTK	0.570	-0.028	3	0.625
PKG1	0.569	-0.091	-2	0.274
MATK	0.569	-0.025	-1	0.414
DDR2	0.569	0.030	3	0.658
TEC	0.569	-0.039	-1	0.380
ROCK2	0.569	-0.085	-3	0.547
PKCI	0.568	-0.168	2	0.279
LYN	0.568	-0.015	3	0.588
PKN1	0.568	-0.114	-3	0.477
KHS1	0.568	-0.106	1	0.610
ITK	0.568	-0.072	-1	0.442
CAMK1A	0.568	-0.062	-3	0.439
VRK1	0.568	-0.223	2	0.349
BMX	0.568	-0.054	-1	0.385
NEK4	0.567	-0.217	1	0.586
ABL1	0.567	-0.066	-1	0.450
PTK2B	0.567	-0.027	-1	0.406
FRK	0.567	-0.039	-1	0.468
ALK	0.567	-0.049	3	0.608
SRC	0.565	-0.036	-1	0.462
CDK6	0.565	-0.066	1	0.472
MEKK6	0.565	-0.254	1	0.623
YSK1	0.565	-0.161	2	0.324
LIMK1_TYR	0.563	-0.217	2	0.394
LOK	0.563	-0.184	-2	0.376
PDGFRA	0.563	-0.097	3	0.636
TEK	0.563	-0.098	3	0.587
LIMK2_TYR	0.563	-0.203	-3	0.599
CDK4	0.563	-0.063	1	0.480
AXL	0.562	-0.121	3	0.635
EPHA1	0.562	-0.050	3	0.619
BTK	0.562	-0.146	-1	0.393
MOK	0.562	-0.071	1	0.540
PTK6	0.562	-0.127	-1	0.409
HASPIN	0.561	-0.094	-1	0.290
STLK3	0.561	-0.088	1	0.607
NEK1	0.560	-0.222	1	0.572
ASK1	0.560	-0.126	1	0.623
TNK2	0.560	-0.101	3	0.665
NEK10_TYR	0.559	-0.130	1	0.564
JAK1	0.558	-0.124	1	0.603
CRIK	0.558	-0.062	-3	0.459
TNNI3K_TYR	0.557	-0.094	1	0.627
WEE1_TYR	0.557	-0.126	-1	0.381
ROCK1	0.555	-0.097	-3	0.525
FES	0.554	-0.035	-1	0.390
NEK3	0.554	-0.197	1	0.584
TAO1	0.553	-0.137	1	0.590
MYO3A	0.549	-0.139	1	0.587
PBK	0.549	-0.150	1	0.509
BIKE	0.547	-0.077	1	0.457
TNK1	0.544	-0.229	3	0.585
MYO3B	0.542	-0.184	2	0.329
MUSK	0.541	-0.115	1	0.494
BUB1	0.534	-0.167	-5	0.541
AAK1	0.526	-0.069	1	0.361