Motif 594 (n=70)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S497 | ochoa | Golgin A8 family member Q | None |
| H3BSY2 | GOLGA8M | S497 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S496 | ochoa | Golgin subfamily A member 8R | None |
| L7N2F9 | None | S61 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O00192 | ARVCF | S887 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O75151 | PHF2 | S929 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75955 | FLOT1 | S163 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O95229 | ZWINT | S81 | ochoa | Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:27881301, PubMed:38459127, PubMed:38459128). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:15094189, PubMed:15485811, PubMed:16732327). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:38459127, PubMed:38459128). Targets the RZZ complex to the kinetochore at prometaphase (PubMed:15485811). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization (By similarity). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:15485811). {ECO:0000250|UniProtKB:Q9CQU5, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:24530301, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| P00533 | EGFR | S229 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02647 | APOA1 | S191 | ochoa | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| P05976 | MYL1 | S73 | ochoa | Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2) | Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. {ECO:0000269|PubMed:30215711}. |
| P0DMV8 | HSPA1A | S362 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S362 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | S362 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11908 | PRPS2 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| P12882 | MYH1 | Y104 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S782 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S784 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13667 | PDIA4 | S468 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P17612 | PRKACA | S140 | ochoa|psp | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P18887 | XRCC1 | S357 | psp | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19484 | TFEB | S97 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20336 | RAB3A | S188 | ochoa | Ras-related protein Rab-3A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:2501306). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:2501306). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:2501306). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). {ECO:0000250|UniProtKB:P63011, ECO:0000250|UniProtKB:P63012, ECO:0000269|PubMed:22248876, ECO:0000269|PubMed:2501306, ECO:0000269|PubMed:27325790, ECO:0000269|PubMed:30599141}. |
| P22694 | PRKACB | S140 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P23763 | VAMP1 | S63 | ochoa | Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1) | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| P25686 | DNAJB2 | S250 | ochoa|psp | DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}. |
| P33527 | ABCC1 | S961 | psp | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P34931 | HSPA1L | S364 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P41146 | OPRL1 | S351 | psp | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}. |
| P42229 | STAT5A | S128 | ochoa | Signal transducer and activator of transcription 5A | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}. |
| P51692 | STAT5B | S128 | ochoa | Signal transducer and activator of transcription 5B | Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:29844444, ECO:0000269|PubMed:8732682}. |
| P55042 | RRAD | S214 | psp | GTP-binding protein RAD (RAD1) (Ras associated with diabetes) | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}. |
| P56545 | CTBP2 | S164 | ochoa|psp | C-terminal-binding protein 2 (CtBP2) | Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 probably acts as a scaffold for specialized synapses. |
| P60484 | PTEN | S113 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P60891 | PRPS1 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P63027 | VAMP2 | S61 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| Q04721 | NOTCH2 | S1778 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q13137 | CALCOCO2 | S315 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q13363 | CTBP1 | S158 | ochoa|psp | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Q15149 | PLEC | S919 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15382 | RHEB | S130 | psp | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q15751 | HERC1 | S1328 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15836 | VAMP3 | S44 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q5SNT2 | TMEM201 | S188 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q7KZF4 | SND1 | S150 | ochoa | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q8N302 | AGGF1 | S169 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8TC05 | MDM1 | S683 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q96T58 | SPEN | S1423 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99801 | NKX3-1 | S186 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BTC0 | DIDO1 | S330 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BV36 | MLPH | S463 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9UER7 | DAXX | S213 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UHD2 | TBK1 | S527 | psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UKX2 | MYH2 | Y104 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | Y104 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UNM6 | PSMD13 | S191 | ochoa | 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9UPP1 | PHF8 | S904 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPV7 | PHF24 | S241 | ochoa | PHD finger protein 24 | None |
| Q9UQ80 | PA2G4 | S267 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y623 | MYH4 | Y104 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| O00506 | STK25 | S133 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| P14649 | MYL6B | S87 | Sugiyama | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| P60660 | MYL6 | S30 | Sugiyama | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | Regulatory light chain of myosin. Does not bind calcium. |
| O15020 | SPTBN2 | S442 | Sugiyama | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| P11277 | SPTB | S439 | Sugiyama | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| Q01082 | SPTBN1 | S439 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| O75150 | RNF40 | S259 | Sugiyama | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| P11498 | PC | S122 | Sugiyama | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. {ECO:0000269|PubMed:9585002}. |
| O00506 | STK25 | S149 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| Q9Y6E0 | STK24 | S149 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.302391e-09 | 8.481 |
| R-HSA-2262752 | Cellular responses to stress | 3.171212e-08 | 7.499 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 9.120422e-07 | 6.040 |
| R-HSA-8963896 | HDL assembly | 6.318526e-06 | 5.199 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 2.089259e-05 | 4.680 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.207151e-05 | 4.656 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 4.597005e-05 | 4.338 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 1.800497e-04 | 3.745 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.922757e-04 | 3.716 |
| R-HSA-111933 | Calmodulin induced events | 1.820774e-04 | 3.740 |
| R-HSA-111997 | CaM pathway | 1.820774e-04 | 3.740 |
| R-HSA-8853659 | RET signaling | 1.820774e-04 | 3.740 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.981565e-04 | 3.526 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.981565e-04 | 3.526 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.981565e-04 | 3.526 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 3.087657e-04 | 3.510 |
| R-HSA-111996 | Ca-dependent events | 3.216777e-04 | 3.493 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.002112e-04 | 3.398 |
| R-HSA-163615 | PKA activation | 4.631151e-04 | 3.334 |
| R-HSA-164378 | PKA activation in glucagon signalling | 4.631151e-04 | 3.334 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 4.959808e-04 | 3.305 |
| R-HSA-6807070 | PTEN Regulation | 5.301899e-04 | 3.276 |
| R-HSA-392517 | Rap1 signalling | 5.237560e-04 | 3.281 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 6.597764e-04 | 3.181 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.620665e-04 | 3.179 |
| R-HSA-422356 | Regulation of insulin secretion | 7.178335e-04 | 3.144 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.008078e-03 | 2.997 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 9.640496e-04 | 3.016 |
| R-HSA-112043 | PLC beta mediated events | 1.063513e-03 | 2.973 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 9.949698e-04 | 3.002 |
| R-HSA-422475 | Axon guidance | 1.029093e-03 | 2.988 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.196421e-03 | 2.922 |
| R-HSA-9645135 | STAT5 Activation | 1.580412e-03 | 2.801 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.580412e-03 | 2.801 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.306083e-03 | 2.884 |
| R-HSA-180024 | DARPP-32 events | 1.543919e-03 | 2.811 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 1.580412e-03 | 2.801 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 1.580412e-03 | 2.801 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.512952e-03 | 2.820 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.512952e-03 | 2.820 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.672339e-03 | 2.777 |
| R-HSA-112040 | G-protein mediated events | 1.441868e-03 | 2.841 |
| R-HSA-373760 | L1CAM interactions | 1.559281e-03 | 2.807 |
| R-HSA-9675108 | Nervous system development | 1.699615e-03 | 2.770 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.821780e-03 | 2.740 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.252103e-03 | 2.647 |
| R-HSA-8985947 | Interleukin-9 signaling | 2.341295e-03 | 2.631 |
| R-HSA-9659379 | Sensory processing of sound | 2.463011e-03 | 2.609 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.759391e-03 | 2.559 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.759391e-03 | 2.559 |
| R-HSA-163560 | Triglyceride catabolism | 2.759391e-03 | 2.559 |
| R-HSA-9833482 | PKR-mediated signaling | 2.565754e-03 | 2.591 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.542837e-03 | 2.595 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 2.774772e-03 | 2.557 |
| R-HSA-9020958 | Interleukin-21 signaling | 2.774772e-03 | 2.557 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 2.774772e-03 | 2.557 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 3.242996e-03 | 2.489 |
| R-HSA-2586552 | Signaling by Leptin | 3.242996e-03 | 2.489 |
| R-HSA-163685 | Integration of energy metabolism | 3.138782e-03 | 2.503 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.123892e-03 | 2.505 |
| R-HSA-9020558 | Interleukin-2 signaling | 3.745515e-03 | 2.426 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.241078e-03 | 2.373 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.327657e-03 | 2.364 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.200844e-03 | 2.377 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.200844e-03 | 2.377 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.437537e-03 | 2.353 |
| R-HSA-162582 | Signal Transduction | 4.264712e-03 | 2.370 |
| R-HSA-8983432 | Interleukin-15 signaling | 4.851652e-03 | 2.314 |
| R-HSA-4641265 | Repression of WNT target genes | 4.851652e-03 | 2.314 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.934813e-03 | 2.307 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.934813e-03 | 2.307 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.195543e-03 | 2.284 |
| R-HSA-9634597 | GPER1 signaling | 5.741545e-03 | 2.241 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.811169e-03 | 2.236 |
| R-HSA-111885 | Opioid Signalling | 6.567223e-03 | 2.183 |
| R-HSA-1170546 | Prolactin receptor signaling | 6.089652e-03 | 2.215 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.666065e-03 | 2.176 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 8.186331e-03 | 2.087 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 8.186331e-03 | 2.087 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.056050e-02 | 1.976 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 9.738969e-03 | 2.011 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.056050e-02 | 1.976 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.051788e-02 | 1.978 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.467502e-03 | 2.024 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.011965e-02 | 1.995 |
| R-HSA-8979227 | Triglyceride metabolism | 9.350023e-03 | 2.029 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 9.738969e-03 | 2.011 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.719978e-03 | 2.012 |
| R-HSA-70326 | Glucose metabolism | 1.023799e-02 | 1.990 |
| R-HSA-68875 | Mitotic Prophase | 1.104806e-02 | 1.957 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.271195e-02 | 1.896 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.271195e-02 | 1.896 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.271195e-02 | 1.896 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.271195e-02 | 1.896 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.271195e-02 | 1.896 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.229194e-02 | 1.910 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.320106e-02 | 1.879 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.413857e-02 | 1.850 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.413857e-02 | 1.850 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 1.413857e-02 | 1.850 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.413857e-02 | 1.850 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.403027e-02 | 1.853 |
| R-HSA-112316 | Neuronal System | 1.342370e-02 | 1.872 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.432957e-02 | 1.844 |
| R-HSA-194138 | Signaling by VEGF | 1.278984e-02 | 1.893 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 1.510408e-02 | 1.821 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.510408e-02 | 1.821 |
| R-HSA-8854691 | Interleukin-20 family signaling | 1.510408e-02 | 1.821 |
| R-HSA-68886 | M Phase | 1.515112e-02 | 1.820 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.609722e-02 | 1.793 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.609722e-02 | 1.793 |
| R-HSA-397014 | Muscle contraction | 1.700018e-02 | 1.770 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.711759e-02 | 1.767 |
| R-HSA-3214842 | HDMs demethylate histones | 1.711759e-02 | 1.767 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.788382e-02 | 1.748 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.816481e-02 | 1.741 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 1.900779e-02 | 1.721 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.923851e-02 | 1.716 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.925167e-02 | 1.716 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.146386e-02 | 1.668 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.261476e-02 | 1.646 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.022905e-02 | 1.694 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.146386e-02 | 1.668 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.146386e-02 | 1.668 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.061969e-02 | 1.686 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.410282e-02 | 1.618 |
| R-HSA-186763 | Downstream signal transduction | 2.379067e-02 | 1.624 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.499123e-02 | 1.602 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.499123e-02 | 1.602 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.500228e-02 | 1.602 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.607698e-02 | 1.584 |
| R-HSA-157118 | Signaling by NOTCH | 2.618011e-02 | 1.582 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.621607e-02 | 1.581 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.675380e-02 | 1.573 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.675380e-02 | 1.573 |
| R-HSA-390522 | Striated Muscle Contraction | 2.746486e-02 | 1.561 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.135137e-02 | 1.504 |
| R-HSA-5682113 | Defective ABCA1 causes TGD | 3.148042e-02 | 1.502 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.175339e-02 | 1.498 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.417230e-02 | 1.466 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.481497e-02 | 1.458 |
| R-HSA-70171 | Glycolysis | 3.481497e-02 | 1.458 |
| R-HSA-71336 | Pentose phosphate pathway | 3.544098e-02 | 1.450 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 3.765772e-02 | 1.424 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 3.765772e-02 | 1.424 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 4.379600e-02 | 1.359 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 4.379600e-02 | 1.359 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 4.379600e-02 | 1.359 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.668304e-02 | 1.331 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.684776e-02 | 1.434 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 3.765772e-02 | 1.424 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.802408e-02 | 1.420 |
| R-HSA-1640170 | Cell Cycle | 4.428582e-02 | 1.354 |
| R-HSA-9607240 | FLT3 Signaling | 3.827578e-02 | 1.417 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.802408e-02 | 1.420 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.640116e-02 | 1.439 |
| R-HSA-75153 | Apoptotic execution phase | 4.727217e-02 | 1.325 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.419389e-02 | 1.355 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.972472e-02 | 1.401 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.759820e-02 | 1.322 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.882814e-02 | 1.311 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 4.989550e-02 | 1.302 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 4.989550e-02 | 1.302 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.042666e-02 | 1.297 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.042666e-02 | 1.297 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.278253e-02 | 1.278 |
| R-HSA-449147 | Signaling by Interleukins | 5.555681e-02 | 1.255 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 5.595647e-02 | 1.252 |
| R-HSA-8964011 | HDL clearance | 5.595647e-02 | 1.252 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.622858e-02 | 1.250 |
| R-HSA-5357801 | Programmed Cell Death | 5.694553e-02 | 1.245 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.695475e-02 | 1.244 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.863072e-02 | 1.232 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.863072e-02 | 1.232 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.863072e-02 | 1.232 |
| R-HSA-8948747 | Regulation of PTEN localization | 6.197915e-02 | 1.208 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 6.197915e-02 | 1.208 |
| R-HSA-114516 | Disinhibition of SNARE formation | 6.197915e-02 | 1.208 |
| R-HSA-446107 | Type I hemidesmosome assembly | 6.796378e-02 | 1.168 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 6.796378e-02 | 1.168 |
| R-HSA-9613354 | Lipophagy | 7.391059e-02 | 1.131 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.999100e-02 | 1.097 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 6.796378e-02 | 1.168 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 9.152651e-02 | 1.038 |
| R-HSA-8963888 | Chylomicron assembly | 8.569172e-02 | 1.067 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 7.391059e-02 | 1.131 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.082331e-02 | 1.150 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 9.152651e-02 | 1.038 |
| R-HSA-6798695 | Neutrophil degranulation | 8.674454e-02 | 1.062 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 8.950452e-02 | 1.048 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 9.152651e-02 | 1.038 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 6.197915e-02 | 1.208 |
| R-HSA-447041 | CHL1 interactions | 6.197915e-02 | 1.208 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 6.796378e-02 | 1.168 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.236771e-02 | 1.205 |
| R-HSA-199991 | Membrane Trafficking | 6.535290e-02 | 1.185 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.413148e-02 | 1.075 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 7.391059e-02 | 1.131 |
| R-HSA-1632852 | Macroautophagy | 8.135454e-02 | 1.090 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.982009e-02 | 1.047 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 7.391059e-02 | 1.131 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.082331e-02 | 1.150 |
| R-HSA-9758890 | Transport of RCbl within the body | 8.569172e-02 | 1.067 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.289669e-02 | 1.081 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.391059e-02 | 1.131 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 8.950452e-02 | 1.048 |
| R-HSA-1643685 | Disease | 9.104574e-02 | 1.041 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.128386e-02 | 1.040 |
| R-HSA-1500931 | Cell-Cell communication | 6.508713e-02 | 1.187 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.228208e-02 | 1.206 |
| R-HSA-186797 | Signaling by PDGF | 7.444687e-02 | 1.128 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.542962e-02 | 1.068 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 9.339990e-02 | 1.030 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.339990e-02 | 1.030 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 9.339990e-02 | 1.030 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.481748e-02 | 1.023 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 9.732442e-02 | 1.012 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 9.732442e-02 | 1.012 |
| R-HSA-9697154 | Disorders of Nervous System Development | 9.732442e-02 | 1.012 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 9.732442e-02 | 1.012 |
| R-HSA-9005895 | Pervasive developmental disorders | 9.732442e-02 | 1.012 |
| R-HSA-9013694 | Signaling by NOTCH4 | 9.734388e-02 | 1.012 |
| R-HSA-1236394 | Signaling by ERBB4 | 9.734388e-02 | 1.012 |
| R-HSA-1226099 | Signaling by FGFR in disease | 9.734388e-02 | 1.012 |
| R-HSA-9612973 | Autophagy | 1.012218e-01 | 0.995 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.088105e-01 | 0.963 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.144992e-01 | 0.941 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.144992e-01 | 0.941 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.424075e-01 | 0.846 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.478838e-01 | 0.830 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.007768e-01 | 0.697 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.852598e-01 | 0.732 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.533254e-01 | 0.814 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.533254e-01 | 0.814 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.313503e-01 | 0.882 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.313503e-01 | 0.882 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.533254e-01 | 0.814 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.368965e-01 | 0.864 |
| R-HSA-180292 | GAB1 signalosome | 1.368965e-01 | 0.864 |
| R-HSA-8964058 | HDL remodeling | 1.424075e-01 | 0.846 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.747498e-01 | 0.758 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.007768e-01 | 0.697 |
| R-HSA-8963901 | Chylomicron remodeling | 1.030857e-01 | 0.987 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.368965e-01 | 0.864 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.144992e-01 | 0.941 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 1.257688e-01 | 0.900 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.058838e-01 | 0.686 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.257688e-01 | 0.900 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.587326e-01 | 0.799 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.641056e-01 | 0.785 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.368965e-01 | 0.864 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.257688e-01 | 0.900 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.257688e-01 | 0.900 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.313503e-01 | 0.882 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.257688e-01 | 0.900 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.368965e-01 | 0.864 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.368965e-01 | 0.864 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.533254e-01 | 0.814 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.800215e-01 | 0.745 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.956372e-01 | 0.709 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.257688e-01 | 0.900 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.058838e-01 | 0.686 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.058838e-01 | 0.686 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.030857e-01 | 0.987 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.641056e-01 | 0.785 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.904650e-01 | 0.720 |
| R-HSA-196780 | Biotin transport and metabolism | 1.144992e-01 | 0.941 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.201519e-01 | 0.920 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.304323e-01 | 0.885 |
| R-HSA-9663891 | Selective autophagy | 1.282932e-01 | 0.892 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.257688e-01 | 0.900 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.792844e-01 | 0.746 |
| R-HSA-418594 | G alpha (i) signalling events | 1.401430e-01 | 0.853 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.088105e-01 | 0.963 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.478838e-01 | 0.830 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.641056e-01 | 0.785 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.088105e-01 | 0.963 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.368965e-01 | 0.864 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.792844e-01 | 0.746 |
| R-HSA-8876725 | Protein methylation | 1.144992e-01 | 0.941 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.533254e-01 | 0.814 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.198240e-01 | 0.921 |
| R-HSA-418555 | G alpha (s) signalling events | 1.228215e-01 | 0.911 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 1.256328e-01 | 0.901 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 1.256328e-01 | 0.901 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.688020e-01 | 0.773 |
| R-HSA-445144 | Signal transduction by L1 | 1.478838e-01 | 0.830 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 1.694446e-01 | 0.771 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.852598e-01 | 0.732 |
| R-HSA-5619084 | ABC transporter disorders | 1.053703e-01 | 0.977 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.694446e-01 | 0.771 |
| R-HSA-4086400 | PCP/CE pathway | 1.053703e-01 | 0.977 |
| R-HSA-202424 | Downstream TCR signaling | 1.325798e-01 | 0.878 |
| R-HSA-373753 | Nephrin family interactions | 1.478838e-01 | 0.830 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.800215e-01 | 0.745 |
| R-HSA-195721 | Signaling by WNT | 1.472864e-01 | 0.832 |
| R-HSA-446728 | Cell junction organization | 1.245779e-01 | 0.905 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.058838e-01 | 0.686 |
| R-HSA-3000170 | Syndecan interactions | 1.694446e-01 | 0.771 |
| R-HSA-168249 | Innate Immune System | 1.537488e-01 | 0.813 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.256328e-01 | 0.901 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.256328e-01 | 0.901 |
| R-HSA-449836 | Other interleukin signaling | 1.424075e-01 | 0.846 |
| R-HSA-264876 | Insulin processing | 1.904650e-01 | 0.720 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.852598e-01 | 0.732 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.278823e-01 | 0.893 |
| R-HSA-9658195 | Leishmania infection | 1.278823e-01 | 0.893 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.595317e-01 | 0.797 |
| R-HSA-418990 | Adherens junctions interactions | 1.958692e-01 | 0.708 |
| R-HSA-202403 | TCR signaling | 1.838615e-01 | 0.736 |
| R-HSA-1483255 | PI Metabolism | 1.634175e-01 | 0.787 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.770027e-01 | 0.752 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.770027e-01 | 0.752 |
| R-HSA-109581 | Apoptosis | 1.091300e-01 | 0.962 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.008991e-01 | 0.697 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.284674e-01 | 0.891 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.069825e-01 | 0.684 |
| R-HSA-182971 | EGFR downregulation | 2.109584e-01 | 0.676 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.109584e-01 | 0.676 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.109584e-01 | 0.676 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.109584e-01 | 0.676 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.109584e-01 | 0.676 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 2.155839e-01 | 0.666 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.160010e-01 | 0.666 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.160010e-01 | 0.666 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.210117e-01 | 0.656 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.210117e-01 | 0.656 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.210117e-01 | 0.656 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.210117e-01 | 0.656 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.210117e-01 | 0.656 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.259906e-01 | 0.646 |
| R-HSA-189483 | Heme degradation | 2.259906e-01 | 0.646 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.309380e-01 | 0.637 |
| R-HSA-5205647 | Mitophagy | 2.309380e-01 | 0.637 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.309380e-01 | 0.637 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.309380e-01 | 0.637 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 2.316903e-01 | 0.635 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.327489e-01 | 0.633 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.358541e-01 | 0.627 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.358541e-01 | 0.627 |
| R-HSA-169911 | Regulation of Apoptosis | 2.358541e-01 | 0.627 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.358541e-01 | 0.627 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.374586e-01 | 0.624 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.407391e-01 | 0.618 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.407391e-01 | 0.618 |
| R-HSA-168256 | Immune System | 2.417413e-01 | 0.617 |
| R-HSA-9909396 | Circadian clock | 2.445330e-01 | 0.612 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 2.455931e-01 | 0.610 |
| R-HSA-4641258 | Degradation of DVL | 2.455931e-01 | 0.610 |
| R-HSA-4641257 | Degradation of AXIN | 2.455931e-01 | 0.610 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.455931e-01 | 0.610 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.455931e-01 | 0.610 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.455931e-01 | 0.610 |
| R-HSA-196757 | Metabolism of folate and pterines | 2.455931e-01 | 0.610 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.468933e-01 | 0.607 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.504165e-01 | 0.601 |
| R-HSA-421270 | Cell-cell junction organization | 2.510091e-01 | 0.600 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.552092e-01 | 0.593 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.552092e-01 | 0.593 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.552092e-01 | 0.593 |
| R-HSA-69541 | Stabilization of p53 | 2.552092e-01 | 0.593 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.552092e-01 | 0.593 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.552092e-01 | 0.593 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.563425e-01 | 0.591 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.587062e-01 | 0.587 |
| R-HSA-913531 | Interferon Signaling | 2.593790e-01 | 0.586 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.599717e-01 | 0.585 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.599717e-01 | 0.585 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.599717e-01 | 0.585 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.599717e-01 | 0.585 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.647039e-01 | 0.577 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.647039e-01 | 0.577 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.647039e-01 | 0.577 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.647039e-01 | 0.577 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.694062e-01 | 0.570 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 2.694062e-01 | 0.570 |
| R-HSA-165159 | MTOR signalling | 2.740787e-01 | 0.562 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.787217e-01 | 0.555 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.802954e-01 | 0.552 |
| R-HSA-9907900 | Proteasome assembly | 2.833352e-01 | 0.548 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.833352e-01 | 0.548 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 2.833352e-01 | 0.548 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 2.833352e-01 | 0.548 |
| R-HSA-2187338 | Visual phototransduction | 2.847110e-01 | 0.546 |
| R-HSA-166520 | Signaling by NTRKs | 2.870730e-01 | 0.542 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.879195e-01 | 0.541 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.879195e-01 | 0.541 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.879195e-01 | 0.541 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.879195e-01 | 0.541 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.879195e-01 | 0.541 |
| R-HSA-9824272 | Somitogenesis | 2.879195e-01 | 0.541 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.879195e-01 | 0.541 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.924747e-01 | 0.534 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.924747e-01 | 0.534 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 2.924747e-01 | 0.534 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.924747e-01 | 0.534 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.965127e-01 | 0.528 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.970011e-01 | 0.527 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.970011e-01 | 0.527 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 3.014988e-01 | 0.521 |
| R-HSA-70263 | Gluconeogenesis | 3.014988e-01 | 0.521 |
| R-HSA-1989781 | PPARA activates gene expression | 3.035814e-01 | 0.518 |
| R-HSA-9766229 | Degradation of CDH1 | 3.059680e-01 | 0.514 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.059680e-01 | 0.514 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.059680e-01 | 0.514 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.082874e-01 | 0.511 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.104089e-01 | 0.508 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.148217e-01 | 0.502 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.148217e-01 | 0.502 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.148217e-01 | 0.502 |
| R-HSA-2514856 | The phototransduction cascade | 3.148217e-01 | 0.502 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.192065e-01 | 0.496 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.192065e-01 | 0.496 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.192065e-01 | 0.496 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.192065e-01 | 0.496 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.192065e-01 | 0.496 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.235635e-01 | 0.490 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.235635e-01 | 0.490 |
| R-HSA-1221632 | Meiotic synapsis | 3.235635e-01 | 0.490 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.235635e-01 | 0.490 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.247082e-01 | 0.489 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.278928e-01 | 0.484 |
| R-HSA-418597 | G alpha (z) signalling events | 3.321948e-01 | 0.479 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.321948e-01 | 0.479 |
| R-HSA-9753281 | Paracetamol ADME | 3.321948e-01 | 0.479 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.321948e-01 | 0.479 |
| R-HSA-177929 | Signaling by EGFR | 3.364694e-01 | 0.473 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.364694e-01 | 0.473 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.364694e-01 | 0.473 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.364694e-01 | 0.473 |
| R-HSA-5578775 | Ion homeostasis | 3.364694e-01 | 0.473 |
| R-HSA-75893 | TNF signaling | 3.364694e-01 | 0.473 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.407170e-01 | 0.468 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.407170e-01 | 0.468 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.479920e-01 | 0.458 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.491315e-01 | 0.457 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.532988e-01 | 0.452 |
| R-HSA-351202 | Metabolism of polyamines | 3.532988e-01 | 0.452 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 3.532988e-01 | 0.452 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.574397e-01 | 0.447 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.574397e-01 | 0.447 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.615543e-01 | 0.442 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.615543e-01 | 0.442 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.615543e-01 | 0.442 |
| R-HSA-9707616 | Heme signaling | 3.615543e-01 | 0.442 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.656428e-01 | 0.437 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.656428e-01 | 0.437 |
| R-HSA-8848021 | Signaling by PTK6 | 3.656428e-01 | 0.437 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.656428e-01 | 0.437 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.656428e-01 | 0.437 |
| R-HSA-373755 | Semaphorin interactions | 3.656428e-01 | 0.437 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.710127e-01 | 0.431 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.737422e-01 | 0.427 |
| R-HSA-1280218 | Adaptive Immune System | 3.742439e-01 | 0.427 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.777534e-01 | 0.423 |
| R-HSA-69275 | G2/M Transition | 3.778589e-01 | 0.423 |
| R-HSA-1266738 | Developmental Biology | 3.785662e-01 | 0.422 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.824064e-01 | 0.417 |
| R-HSA-5218859 | Regulated Necrosis | 3.856997e-01 | 0.414 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.914594e-01 | 0.407 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.935454e-01 | 0.405 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.935454e-01 | 0.405 |
| R-HSA-68877 | Mitotic Prometaphase | 3.937136e-01 | 0.405 |
| R-HSA-975634 | Retinoid metabolism and transport | 3.974310e-01 | 0.401 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.974310e-01 | 0.401 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.974310e-01 | 0.401 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 3.974310e-01 | 0.401 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.974310e-01 | 0.401 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.974310e-01 | 0.401 |
| R-HSA-189445 | Metabolism of porphyrins | 3.974310e-01 | 0.401 |
| R-HSA-388396 | GPCR downstream signalling | 3.993097e-01 | 0.399 |
| R-HSA-9609690 | HCMV Early Events | 4.004540e-01 | 0.397 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.012920e-01 | 0.397 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.051284e-01 | 0.392 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.051284e-01 | 0.392 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.051284e-01 | 0.392 |
| R-HSA-4086398 | Ca2+ pathway | 4.051284e-01 | 0.392 |
| R-HSA-380287 | Centrosome maturation | 4.127283e-01 | 0.384 |
| R-HSA-8852135 | Protein ubiquitination | 4.127283e-01 | 0.384 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.127283e-01 | 0.384 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.127283e-01 | 0.384 |
| R-HSA-5663205 | Infectious disease | 4.143571e-01 | 0.383 |
| R-HSA-5689603 | UCH proteinases | 4.164922e-01 | 0.380 |
| R-HSA-212436 | Generic Transcription Pathway | 4.249394e-01 | 0.372 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 4.349561e-01 | 0.362 |
| R-HSA-977225 | Amyloid fiber formation | 4.349561e-01 | 0.362 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.401364e-01 | 0.356 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.421785e-01 | 0.354 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.421785e-01 | 0.354 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.457554e-01 | 0.351 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.457554e-01 | 0.351 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.457554e-01 | 0.351 |
| R-HSA-68882 | Mitotic Anaphase | 4.466142e-01 | 0.350 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.487643e-01 | 0.348 |
| R-HSA-1500620 | Meiosis | 4.493096e-01 | 0.347 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.493096e-01 | 0.347 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.528412e-01 | 0.344 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.528412e-01 | 0.344 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.528412e-01 | 0.344 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.528412e-01 | 0.344 |
| R-HSA-70268 | Pyruvate metabolism | 4.598372e-01 | 0.337 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.633019e-01 | 0.334 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.679046e-01 | 0.330 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.701655e-01 | 0.328 |
| R-HSA-73884 | Base Excision Repair | 4.701655e-01 | 0.328 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.794439e-01 | 0.319 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.802982e-01 | 0.318 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.836329e-01 | 0.315 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.845891e-01 | 0.315 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.869465e-01 | 0.313 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.869465e-01 | 0.313 |
| R-HSA-1474290 | Collagen formation | 4.869465e-01 | 0.313 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.902389e-01 | 0.310 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.935105e-01 | 0.307 |
| R-HSA-2168880 | Scavenging of heme from plasma | 4.935105e-01 | 0.307 |
| R-HSA-372790 | Signaling by GPCR | 4.937705e-01 | 0.306 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.967613e-01 | 0.304 |
| R-HSA-157579 | Telomere Maintenance | 4.999914e-01 | 0.301 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.999914e-01 | 0.301 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.032009e-01 | 0.298 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.095590e-01 | 0.293 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.110106e-01 | 0.292 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.127077e-01 | 0.290 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.127077e-01 | 0.290 |
| R-HSA-597592 | Post-translational protein modification | 5.144641e-01 | 0.289 |
| R-HSA-4839726 | Chromatin organization | 5.149974e-01 | 0.288 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.158364e-01 | 0.287 |
| R-HSA-9609646 | HCMV Infection | 5.169829e-01 | 0.287 |
| R-HSA-5688426 | Deubiquitination | 5.268305e-01 | 0.278 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.281536e-01 | 0.277 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.281536e-01 | 0.277 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.311841e-01 | 0.275 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.326747e-01 | 0.274 |
| R-HSA-69239 | Synthesis of DNA | 5.341953e-01 | 0.272 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.401604e-01 | 0.267 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.401604e-01 | 0.267 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.412567e-01 | 0.267 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.423068e-01 | 0.266 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.430747e-01 | 0.265 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.431145e-01 | 0.265 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.431145e-01 | 0.265 |
| R-HSA-416476 | G alpha (q) signalling events | 5.442169e-01 | 0.264 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.489665e-01 | 0.260 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.576055e-01 | 0.254 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.630163e-01 | 0.249 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.688699e-01 | 0.245 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.688699e-01 | 0.245 |
| R-HSA-5693538 | Homology Directed Repair | 5.716413e-01 | 0.243 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.743950e-01 | 0.241 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.776578e-01 | 0.238 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.798501e-01 | 0.237 |
| R-HSA-73886 | Chromosome Maintenance | 5.798501e-01 | 0.237 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.852359e-01 | 0.233 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.852359e-01 | 0.233 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.879031e-01 | 0.231 |
| R-HSA-109582 | Hemostasis | 5.902812e-01 | 0.229 |
| R-HSA-69206 | G1/S Transition | 5.931866e-01 | 0.227 |
| R-HSA-114608 | Platelet degranulation | 5.984031e-01 | 0.223 |
| R-HSA-69481 | G2/M Checkpoints | 5.984031e-01 | 0.223 |
| R-HSA-1483257 | Phospholipid metabolism | 6.006896e-01 | 0.221 |
| R-HSA-1474165 | Reproduction | 6.086381e-01 | 0.216 |
| R-HSA-5576891 | Cardiac conduction | 6.111562e-01 | 0.214 |
| R-HSA-382551 | Transport of small molecules | 6.243534e-01 | 0.205 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.307320e-01 | 0.200 |
| R-HSA-9664407 | Parasite infection | 6.354714e-01 | 0.197 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.354714e-01 | 0.197 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.354714e-01 | 0.197 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.378185e-01 | 0.195 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.424679e-01 | 0.192 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.470581e-01 | 0.189 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.515900e-01 | 0.186 |
| R-HSA-69242 | S Phase | 6.560643e-01 | 0.183 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.560643e-01 | 0.183 |
| R-HSA-9758941 | Gastrulation | 6.582800e-01 | 0.182 |
| R-HSA-1474244 | Extracellular matrix organization | 6.595516e-01 | 0.181 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.604816e-01 | 0.180 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.604816e-01 | 0.180 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.604816e-01 | 0.180 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.648428e-01 | 0.177 |
| R-HSA-2142753 | Arachidonate metabolism | 6.648428e-01 | 0.177 |
| R-HSA-9609507 | Protein localization | 6.670025e-01 | 0.176 |
| R-HSA-69306 | DNA Replication | 6.670025e-01 | 0.176 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.670025e-01 | 0.176 |
| R-HSA-73887 | Death Receptor Signaling | 6.691484e-01 | 0.174 |
| R-HSA-9711097 | Cellular response to starvation | 6.775961e-01 | 0.169 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.775961e-01 | 0.169 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.817395e-01 | 0.166 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.074153e-01 | 0.150 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.111790e-01 | 0.148 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.130428e-01 | 0.147 |
| R-HSA-168255 | Influenza Infection | 7.203797e-01 | 0.142 |
| R-HSA-2559583 | Cellular Senescence | 7.221847e-01 | 0.141 |
| R-HSA-3781865 | Diseases of glycosylation | 7.292901e-01 | 0.137 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.327750e-01 | 0.135 |
| R-HSA-5617833 | Cilium Assembly | 7.396121e-01 | 0.131 |
| R-HSA-74160 | Gene expression (Transcription) | 7.407830e-01 | 0.130 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.412941e-01 | 0.130 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.421293e-01 | 0.130 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.462759e-01 | 0.127 |
| R-HSA-9824446 | Viral Infection Pathways | 7.509026e-01 | 0.124 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.559562e-01 | 0.122 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.559562e-01 | 0.122 |
| R-HSA-428157 | Sphingolipid metabolism | 7.575336e-01 | 0.121 |
| R-HSA-556833 | Metabolism of lipids | 7.597749e-01 | 0.119 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.606583e-01 | 0.119 |
| R-HSA-72172 | mRNA Splicing | 7.637430e-01 | 0.117 |
| R-HSA-5668914 | Diseases of metabolism | 7.841286e-01 | 0.106 |
| R-HSA-9748784 | Drug ADME | 7.842612e-01 | 0.106 |
| R-HSA-8951664 | Neddylation | 7.884229e-01 | 0.103 |
| R-HSA-392499 | Metabolism of proteins | 7.962444e-01 | 0.099 |
| R-HSA-162906 | HIV Infection | 7.965091e-01 | 0.099 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.978267e-01 | 0.098 |
| R-HSA-8953854 | Metabolism of RNA | 8.031826e-01 | 0.095 |
| R-HSA-8939211 | ESR-mediated signaling | 8.093115e-01 | 0.092 |
| R-HSA-9709957 | Sensory Perception | 8.240476e-01 | 0.084 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.314781e-01 | 0.080 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.549214e-01 | 0.068 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.889792e-01 | 0.051 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.032233e-01 | 0.044 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.081599e-01 | 0.042 |
| R-HSA-73894 | DNA Repair | 9.145429e-01 | 0.039 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.162062e-01 | 0.038 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.320701e-01 | 0.031 |
| R-HSA-8978868 | Fatty acid metabolism | 9.376297e-01 | 0.028 |
| R-HSA-72766 | Translation | 9.460301e-01 | 0.024 |
| R-HSA-9679506 | SARS-CoV Infections | 9.765243e-01 | 0.010 |
| R-HSA-500792 | GPCR ligand binding | 9.812691e-01 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.845563e-01 | 0.007 |
| R-HSA-1430728 | Metabolism | 9.902204e-01 | 0.004 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.728 | 0.303 | 1 | 0.722 |
RSK2 |
0.726 | 0.167 | -3 | 0.790 |
PRKD2 |
0.725 | 0.141 | -3 | 0.797 |
PIM3 |
0.724 | 0.151 | -3 | 0.806 |
P70S6KB |
0.724 | 0.192 | -3 | 0.808 |
PIM1 |
0.720 | 0.159 | -3 | 0.787 |
PRKD1 |
0.720 | 0.101 | -3 | 0.815 |
NDR2 |
0.719 | 0.072 | -3 | 0.800 |
RSK3 |
0.718 | 0.145 | -3 | 0.793 |
MAPKAPK2 |
0.717 | 0.126 | -3 | 0.768 |
P90RSK |
0.716 | 0.134 | -3 | 0.782 |
CLK3 |
0.716 | 0.117 | 1 | 0.598 |
NDR1 |
0.715 | 0.088 | -3 | 0.817 |
PRKX |
0.715 | 0.162 | -3 | 0.715 |
RSK4 |
0.714 | 0.179 | -3 | 0.751 |
MAPKAPK3 |
0.714 | 0.104 | -3 | 0.801 |
COT |
0.714 | 0.010 | 2 | 0.796 |
IKKB |
0.713 | 0.031 | -2 | 0.656 |
PKACG |
0.712 | 0.110 | -2 | 0.748 |
PKACB |
0.712 | 0.145 | -2 | 0.705 |
AURC |
0.712 | 0.121 | -2 | 0.693 |
LATS2 |
0.711 | 0.056 | -5 | 0.613 |
PAK6 |
0.710 | 0.109 | -2 | 0.737 |
RAF1 |
0.710 | 0.035 | 1 | 0.582 |
MSK2 |
0.709 | 0.114 | -3 | 0.757 |
NLK |
0.709 | 0.088 | 1 | 0.554 |
MSK1 |
0.709 | 0.146 | -3 | 0.777 |
P70S6K |
0.708 | 0.186 | -3 | 0.757 |
CAMK1B |
0.708 | 0.074 | -3 | 0.834 |
CAMLCK |
0.708 | 0.136 | -2 | 0.792 |
MOS |
0.707 | 0.143 | 1 | 0.698 |
PRKD3 |
0.707 | 0.106 | -3 | 0.779 |
AURB |
0.707 | 0.131 | -2 | 0.697 |
PRPK |
0.707 | -0.014 | -1 | 0.631 |
CDKL1 |
0.707 | 0.080 | -3 | 0.798 |
PAK1 |
0.706 | 0.105 | -2 | 0.751 |
PIM2 |
0.706 | 0.155 | -3 | 0.776 |
AMPKA1 |
0.706 | 0.054 | -3 | 0.831 |
PKN3 |
0.705 | 0.039 | -3 | 0.806 |
GCN2 |
0.705 | -0.046 | 2 | 0.711 |
GRK1 |
0.705 | 0.100 | -2 | 0.643 |
IKKA |
0.704 | 0.044 | -2 | 0.618 |
PKCD |
0.704 | 0.055 | 2 | 0.682 |
AMPKA2 |
0.704 | 0.065 | -3 | 0.821 |
HIPK4 |
0.704 | 0.032 | 1 | 0.573 |
DAPK2 |
0.704 | 0.139 | -3 | 0.827 |
SRPK1 |
0.704 | 0.051 | -3 | 0.767 |
CAMK2G |
0.704 | 0.005 | 2 | 0.742 |
SRPK2 |
0.703 | 0.072 | -3 | 0.713 |
PAK3 |
0.703 | 0.092 | -2 | 0.756 |
ERK5 |
0.703 | 0.053 | 1 | 0.507 |
PKG2 |
0.703 | 0.120 | -2 | 0.718 |
CAMK2B |
0.703 | 0.083 | 2 | 0.751 |
CLK4 |
0.703 | 0.114 | -3 | 0.776 |
CAMK2D |
0.703 | 0.025 | -3 | 0.819 |
AURA |
0.703 | 0.128 | -2 | 0.660 |
TBK1 |
0.702 | -0.060 | 1 | 0.474 |
MARK4 |
0.702 | -0.009 | 4 | 0.536 |
CDKL5 |
0.702 | 0.051 | -3 | 0.797 |
ATR |
0.702 | -0.000 | 1 | 0.584 |
MST4 |
0.702 | -0.011 | 2 | 0.752 |
DYRK2 |
0.702 | 0.056 | 1 | 0.497 |
SGK3 |
0.701 | 0.125 | -3 | 0.794 |
IKKE |
0.701 | -0.050 | 1 | 0.477 |
GRK6 |
0.701 | 0.110 | 1 | 0.616 |
PKACA |
0.701 | 0.139 | -2 | 0.678 |
MNK2 |
0.701 | 0.053 | -2 | 0.774 |
MELK |
0.701 | 0.060 | -3 | 0.817 |
TSSK1 |
0.700 | 0.042 | -3 | 0.842 |
ULK2 |
0.700 | -0.084 | 2 | 0.689 |
PDHK1 |
0.700 | -0.090 | 1 | 0.585 |
BMPR2 |
0.700 | -0.006 | -2 | 0.737 |
TSSK2 |
0.700 | 0.066 | -5 | 0.688 |
CLK1 |
0.700 | 0.100 | -3 | 0.775 |
SKMLCK |
0.699 | 0.051 | -2 | 0.761 |
NUAK2 |
0.699 | 0.019 | -3 | 0.821 |
PDHK4 |
0.699 | -0.146 | 1 | 0.575 |
CHK1 |
0.699 | 0.073 | -3 | 0.829 |
WNK3 |
0.699 | -0.041 | 1 | 0.542 |
AKT2 |
0.699 | 0.118 | -3 | 0.732 |
QSK |
0.698 | 0.023 | 4 | 0.512 |
ATM |
0.698 | 0.038 | 1 | 0.571 |
FAM20C |
0.698 | 0.092 | 2 | 0.613 |
NIK |
0.698 | 0.017 | -3 | 0.831 |
DSTYK |
0.698 | -0.028 | 2 | 0.780 |
NIM1 |
0.698 | -0.013 | 3 | 0.668 |
PAK2 |
0.697 | 0.098 | -2 | 0.750 |
CHAK2 |
0.697 | -0.007 | -1 | 0.618 |
AKT1 |
0.697 | 0.135 | -3 | 0.750 |
GRK5 |
0.697 | 0.015 | -3 | 0.734 |
PKN2 |
0.697 | 0.012 | -3 | 0.827 |
WNK1 |
0.697 | -0.032 | -2 | 0.749 |
CAMK4 |
0.697 | 0.050 | -3 | 0.806 |
NEK6 |
0.697 | -0.036 | -2 | 0.694 |
TGFBR2 |
0.697 | -0.019 | -2 | 0.643 |
SIK |
0.696 | 0.032 | -3 | 0.773 |
MNK1 |
0.696 | 0.059 | -2 | 0.794 |
ICK |
0.696 | 0.035 | -3 | 0.810 |
BMPR1B |
0.696 | 0.163 | 1 | 0.656 |
CLK2 |
0.696 | 0.118 | -3 | 0.769 |
MTOR |
0.696 | -0.137 | 1 | 0.505 |
SMG1 |
0.695 | 0.125 | 1 | 0.545 |
LATS1 |
0.694 | 0.067 | -3 | 0.797 |
PAK5 |
0.694 | 0.094 | -2 | 0.686 |
MYLK4 |
0.693 | 0.116 | -2 | 0.743 |
BRSK1 |
0.693 | 0.035 | -3 | 0.802 |
ALK2 |
0.693 | 0.198 | -2 | 0.637 |
RIPK3 |
0.693 | -0.042 | 3 | 0.605 |
NEK7 |
0.693 | -0.069 | -3 | 0.737 |
BCKDK |
0.693 | -0.117 | -1 | 0.546 |
CAMK2A |
0.692 | 0.038 | 2 | 0.729 |
DYRK3 |
0.692 | 0.096 | 1 | 0.513 |
NUAK1 |
0.692 | 0.005 | -3 | 0.803 |
MAPKAPK5 |
0.692 | 0.035 | -3 | 0.756 |
PKR |
0.691 | 0.054 | 1 | 0.571 |
BMPR1A |
0.691 | 0.204 | 1 | 0.686 |
CDK7 |
0.691 | -0.009 | 1 | 0.463 |
MARK2 |
0.690 | 0.003 | 4 | 0.461 |
CDK8 |
0.690 | -0.007 | 1 | 0.467 |
QIK |
0.690 | -0.027 | -3 | 0.803 |
NEK9 |
0.689 | -0.060 | 2 | 0.730 |
SRPK3 |
0.689 | 0.034 | -3 | 0.738 |
ULK1 |
0.689 | -0.102 | -3 | 0.715 |
SGK1 |
0.689 | 0.144 | -3 | 0.678 |
MRCKB |
0.689 | 0.153 | -3 | 0.775 |
MRCKA |
0.689 | 0.162 | -3 | 0.778 |
MARK3 |
0.689 | -0.006 | 4 | 0.474 |
DYRK1A |
0.689 | 0.059 | 1 | 0.503 |
JNK2 |
0.688 | 0.049 | 1 | 0.407 |
DYRK1B |
0.688 | 0.065 | 1 | 0.428 |
MLK1 |
0.688 | -0.085 | 2 | 0.698 |
HIPK1 |
0.688 | 0.054 | 1 | 0.500 |
HIPK2 |
0.688 | 0.040 | 1 | 0.435 |
BRSK2 |
0.688 | -0.018 | -3 | 0.812 |
ALK4 |
0.687 | 0.058 | -2 | 0.669 |
HUNK |
0.687 | -0.100 | 2 | 0.696 |
PAK4 |
0.687 | 0.082 | -2 | 0.683 |
AKT3 |
0.686 | 0.122 | -3 | 0.687 |
MARK1 |
0.685 | -0.002 | 4 | 0.496 |
DLK |
0.685 | -0.068 | 1 | 0.569 |
MLK2 |
0.685 | -0.089 | 2 | 0.717 |
DYRK4 |
0.685 | 0.045 | 1 | 0.441 |
ACVR2B |
0.684 | 0.105 | -2 | 0.643 |
BRAF |
0.684 | 0.081 | -4 | 0.719 |
TGFBR1 |
0.684 | 0.045 | -2 | 0.623 |
CAMK1D |
0.684 | 0.091 | -3 | 0.730 |
PKCA |
0.684 | -0.015 | 2 | 0.617 |
DAPK3 |
0.684 | 0.153 | -3 | 0.795 |
RIPK1 |
0.684 | -0.090 | 1 | 0.528 |
DNAPK |
0.683 | -0.018 | 1 | 0.464 |
MASTL |
0.683 | -0.164 | -2 | 0.720 |
GRK4 |
0.683 | -0.047 | -2 | 0.653 |
ROCK2 |
0.683 | 0.147 | -3 | 0.797 |
CDK19 |
0.683 | -0.019 | 1 | 0.434 |
PKG1 |
0.683 | 0.110 | -2 | 0.687 |
TTBK2 |
0.683 | -0.060 | 2 | 0.587 |
PKCB |
0.683 | -0.027 | 2 | 0.626 |
JNK3 |
0.682 | 0.032 | 1 | 0.438 |
ACVR2A |
0.682 | 0.060 | -2 | 0.632 |
PLK1 |
0.682 | -0.038 | -2 | 0.686 |
IRE1 |
0.681 | -0.110 | 1 | 0.528 |
SSTK |
0.681 | 0.025 | 4 | 0.490 |
PKCH |
0.681 | -0.018 | 2 | 0.608 |
PKCT |
0.681 | 0.007 | 2 | 0.626 |
GRK7 |
0.681 | 0.038 | 1 | 0.533 |
IRE2 |
0.680 | -0.076 | 2 | 0.662 |
PKCG |
0.680 | -0.040 | 2 | 0.613 |
NEK2 |
0.680 | -0.073 | 2 | 0.696 |
KIS |
0.680 | -0.047 | 1 | 0.484 |
PHKG1 |
0.680 | -0.057 | -3 | 0.809 |
CDK13 |
0.680 | -0.029 | 1 | 0.435 |
SMMLCK |
0.679 | 0.081 | -3 | 0.815 |
HIPK3 |
0.679 | 0.029 | 1 | 0.486 |
ANKRD3 |
0.679 | -0.124 | 1 | 0.569 |
PRP4 |
0.679 | 0.041 | -3 | 0.672 |
PKCZ |
0.679 | -0.056 | 2 | 0.669 |
DCAMKL1 |
0.679 | 0.023 | -3 | 0.797 |
P38A |
0.678 | 0.004 | 1 | 0.450 |
MLK3 |
0.678 | -0.063 | 2 | 0.625 |
CRIK |
0.678 | 0.182 | -3 | 0.745 |
PERK |
0.678 | -0.034 | -2 | 0.699 |
MEK1 |
0.677 | -0.047 | 2 | 0.733 |
PHKG2 |
0.677 | -0.017 | -3 | 0.810 |
SNRK |
0.677 | -0.046 | 2 | 0.598 |
CDK9 |
0.677 | -0.027 | 1 | 0.433 |
CHAK1 |
0.677 | -0.075 | 2 | 0.638 |
VRK2 |
0.677 | -0.075 | 1 | 0.614 |
P38B |
0.677 | 0.013 | 1 | 0.405 |
WNK4 |
0.677 | -0.058 | -2 | 0.746 |
CDK5 |
0.677 | -0.017 | 1 | 0.470 |
DAPK1 |
0.676 | 0.131 | -3 | 0.782 |
PLK3 |
0.676 | -0.028 | 2 | 0.689 |
CDK18 |
0.676 | -0.028 | 1 | 0.392 |
SBK |
0.676 | 0.092 | -3 | 0.654 |
YSK4 |
0.675 | -0.084 | 1 | 0.508 |
CDK14 |
0.675 | 0.006 | 1 | 0.413 |
CK2A2 |
0.675 | 0.083 | 1 | 0.548 |
ERK2 |
0.674 | 0.003 | 1 | 0.418 |
PINK1 |
0.674 | -0.062 | 1 | 0.572 |
CDK12 |
0.674 | -0.029 | 1 | 0.412 |
CAMK1G |
0.674 | 0.010 | -3 | 0.779 |
ROCK1 |
0.674 | 0.139 | -3 | 0.785 |
CDK1 |
0.673 | -0.010 | 1 | 0.413 |
BUB1 |
0.673 | 0.079 | -5 | 0.674 |
P38G |
0.673 | 0.000 | 1 | 0.352 |
CDK2 |
0.673 | 0.001 | 1 | 0.458 |
P38D |
0.673 | 0.027 | 1 | 0.393 |
CDK3 |
0.673 | 0.026 | 1 | 0.374 |
CDK4 |
0.672 | 0.019 | 1 | 0.407 |
TLK2 |
0.672 | -0.087 | 1 | 0.570 |
DRAK1 |
0.672 | -0.047 | 1 | 0.438 |
ERK1 |
0.672 | -0.006 | 1 | 0.395 |
HRI |
0.671 | -0.107 | -2 | 0.697 |
MLK4 |
0.671 | -0.084 | 2 | 0.618 |
IRAK4 |
0.671 | -0.067 | 1 | 0.534 |
CAMKK1 |
0.671 | 0.041 | -2 | 0.722 |
PKN1 |
0.670 | 0.027 | -3 | 0.767 |
CAMK1A |
0.670 | 0.077 | -3 | 0.720 |
CDK17 |
0.669 | -0.030 | 1 | 0.353 |
MEKK1 |
0.669 | -0.098 | 1 | 0.564 |
PKCI |
0.669 | -0.020 | 2 | 0.627 |
CDK10 |
0.668 | 0.004 | 1 | 0.402 |
CHK2 |
0.668 | 0.067 | -3 | 0.703 |
MOK |
0.668 | 0.054 | 1 | 0.496 |
DCAMKL2 |
0.667 | -0.013 | -3 | 0.814 |
PKCE |
0.667 | 0.013 | 2 | 0.594 |
PLK4 |
0.667 | -0.114 | 2 | 0.571 |
IRAK1 |
0.667 | -0.105 | -1 | 0.595 |
TAO3 |
0.667 | -0.054 | 1 | 0.513 |
ZAK |
0.667 | -0.107 | 1 | 0.545 |
PASK |
0.665 | 0.001 | -3 | 0.798 |
CAMKK2 |
0.665 | 0.014 | -2 | 0.740 |
DMPK1 |
0.665 | 0.115 | -3 | 0.784 |
CDK16 |
0.665 | -0.021 | 1 | 0.372 |
LOK |
0.665 | 0.002 | -2 | 0.741 |
TAO2 |
0.664 | -0.038 | 2 | 0.743 |
LKB1 |
0.664 | -0.017 | -3 | 0.749 |
MEK5 |
0.664 | -0.160 | 2 | 0.717 |
MAK |
0.663 | 0.044 | -2 | 0.645 |
NEK5 |
0.663 | -0.092 | 1 | 0.537 |
TTBK1 |
0.662 | -0.053 | 2 | 0.505 |
CK2A1 |
0.662 | 0.051 | 1 | 0.511 |
MPSK1 |
0.662 | -0.059 | 1 | 0.529 |
TAK1 |
0.660 | 0.068 | 1 | 0.584 |
CDK6 |
0.660 | -0.007 | 1 | 0.404 |
MST3 |
0.660 | -0.086 | 2 | 0.703 |
JNK1 |
0.660 | 0.013 | 1 | 0.395 |
ERK7 |
0.660 | -0.005 | 2 | 0.447 |
NEK8 |
0.659 | -0.066 | 2 | 0.698 |
GSK3B |
0.658 | -0.069 | 4 | 0.219 |
GRK2 |
0.658 | -0.084 | -2 | 0.554 |
PDK1 |
0.658 | -0.057 | 1 | 0.509 |
GAK |
0.657 | -0.044 | 1 | 0.542 |
MEKK2 |
0.656 | -0.144 | 2 | 0.698 |
TNIK |
0.656 | -0.042 | 3 | 0.732 |
PDHK3_TYR |
0.656 | 0.107 | 4 | 0.622 |
PBK |
0.656 | -0.016 | 1 | 0.475 |
MEKK3 |
0.655 | -0.175 | 1 | 0.517 |
HGK |
0.655 | -0.072 | 3 | 0.711 |
RIPK2 |
0.655 | -0.075 | 1 | 0.502 |
NEK4 |
0.654 | -0.086 | 1 | 0.504 |
VRK1 |
0.654 | -0.019 | 2 | 0.741 |
SLK |
0.654 | -0.043 | -2 | 0.674 |
MEK2 |
0.653 | -0.036 | 2 | 0.717 |
GSK3A |
0.653 | -0.069 | 4 | 0.234 |
TLK1 |
0.652 | -0.149 | -2 | 0.622 |
NEK1 |
0.652 | -0.057 | 1 | 0.516 |
MEKK6 |
0.652 | -0.118 | 1 | 0.531 |
MINK |
0.651 | -0.085 | 1 | 0.501 |
NEK3 |
0.651 | -0.084 | 1 | 0.506 |
LIMK2_TYR |
0.650 | 0.002 | -3 | 0.830 |
PLK2 |
0.650 | -0.010 | -3 | 0.705 |
LRRK2 |
0.650 | -0.105 | 2 | 0.734 |
TESK1_TYR |
0.648 | -0.037 | 3 | 0.750 |
YSK1 |
0.648 | -0.078 | 2 | 0.693 |
MAP2K4_TYR |
0.648 | 0.018 | -1 | 0.619 |
GRK3 |
0.647 | -0.074 | -2 | 0.503 |
EEF2K |
0.647 | -0.039 | 3 | 0.685 |
GCK |
0.646 | -0.106 | 1 | 0.488 |
HPK1 |
0.645 | -0.082 | 1 | 0.468 |
SRMS |
0.645 | 0.172 | 1 | 0.647 |
MAP2K7_TYR |
0.645 | -0.077 | 2 | 0.754 |
TYRO3 |
0.645 | 0.083 | 3 | 0.685 |
PINK1_TYR |
0.645 | -0.064 | 1 | 0.571 |
STK33 |
0.644 | -0.111 | 2 | 0.511 |
NEK11 |
0.644 | -0.208 | 1 | 0.501 |
PKMYT1_TYR |
0.644 | -0.099 | 3 | 0.718 |
RET |
0.644 | -0.028 | 1 | 0.546 |
MST2 |
0.644 | -0.116 | 1 | 0.528 |
ALPHAK3 |
0.644 | 0.124 | -1 | 0.562 |
KHS1 |
0.643 | -0.080 | 1 | 0.489 |
FER |
0.643 | 0.109 | 1 | 0.658 |
PDHK4_TYR |
0.643 | -0.014 | 2 | 0.786 |
TXK |
0.643 | 0.152 | 1 | 0.600 |
EPHA6 |
0.643 | 0.072 | -1 | 0.602 |
KHS2 |
0.642 | -0.059 | 1 | 0.484 |
PTK6 |
0.642 | 0.076 | -1 | 0.654 |
CK1E |
0.642 | -0.104 | -3 | 0.377 |
MAP3K15 |
0.642 | -0.161 | 1 | 0.516 |
BIKE |
0.642 | -0.012 | 1 | 0.446 |
TAO1 |
0.642 | -0.057 | 1 | 0.472 |
AXL |
0.641 | 0.086 | 3 | 0.661 |
EPHB4 |
0.641 | 0.099 | -1 | 0.626 |
MAP2K6_TYR |
0.641 | -0.053 | -1 | 0.597 |
TEC |
0.641 | 0.158 | -1 | 0.694 |
MERTK |
0.641 | 0.136 | 3 | 0.664 |
NEK10_TYR |
0.640 | -0.011 | 1 | 0.442 |
TYK2 |
0.640 | -0.085 | 1 | 0.558 |
LIMK1_TYR |
0.640 | -0.105 | 2 | 0.746 |
TEK |
0.639 | 0.082 | 3 | 0.624 |
ABL2 |
0.639 | 0.027 | -1 | 0.657 |
ROS1 |
0.639 | -0.008 | 3 | 0.659 |
MST1R |
0.639 | -0.059 | 3 | 0.682 |
OSR1 |
0.638 | -0.048 | 2 | 0.700 |
EPHA4 |
0.638 | 0.119 | 2 | 0.683 |
EPHB1 |
0.637 | 0.112 | 1 | 0.642 |
EPHB3 |
0.637 | 0.123 | -1 | 0.624 |
TNK2 |
0.637 | 0.024 | 3 | 0.630 |
HASPIN |
0.637 | -0.067 | -1 | 0.487 |
ITK |
0.637 | 0.067 | -1 | 0.671 |
BTK |
0.637 | 0.119 | -1 | 0.718 |
CK1G1 |
0.637 | -0.118 | -3 | 0.361 |
MYO3B |
0.636 | -0.062 | 2 | 0.708 |
BMX |
0.636 | 0.099 | -1 | 0.663 |
JAK2 |
0.636 | -0.092 | 1 | 0.558 |
BMPR2_TYR |
0.636 | -0.100 | -1 | 0.578 |
MST1 |
0.635 | -0.146 | 1 | 0.499 |
ABL1 |
0.635 | 0.015 | -1 | 0.663 |
PDHK1_TYR |
0.635 | -0.080 | -1 | 0.598 |
LTK |
0.635 | 0.056 | 3 | 0.618 |
CSF1R |
0.634 | -0.053 | 3 | 0.659 |
EPHB2 |
0.634 | 0.128 | -1 | 0.613 |
FLT3 |
0.634 | -0.024 | 3 | 0.661 |
EPHA1 |
0.634 | 0.099 | 3 | 0.637 |
TNK1 |
0.633 | -0.065 | 3 | 0.667 |
DDR1 |
0.633 | -0.089 | 4 | 0.510 |
TTK |
0.633 | -0.053 | -2 | 0.659 |
HCK |
0.632 | 0.038 | -1 | 0.656 |
CK1D |
0.632 | -0.102 | -3 | 0.322 |
YES1 |
0.632 | 0.024 | -1 | 0.654 |
EPHA7 |
0.632 | 0.107 | 2 | 0.687 |
LCK |
0.632 | 0.033 | -1 | 0.640 |
CK1A2 |
0.631 | -0.108 | -3 | 0.331 |
PDGFRB |
0.630 | -0.085 | 3 | 0.666 |
MYO3A |
0.630 | -0.081 | 1 | 0.506 |
ALK |
0.629 | 0.014 | 3 | 0.592 |
FGFR2 |
0.629 | -0.075 | 3 | 0.655 |
ASK1 |
0.629 | -0.102 | 1 | 0.521 |
AAK1 |
0.628 | -0.005 | 1 | 0.362 |
BLK |
0.628 | 0.058 | -1 | 0.618 |
INSRR |
0.628 | -0.038 | 3 | 0.621 |
FGFR1 |
0.627 | -0.085 | 3 | 0.652 |
JAK3 |
0.627 | -0.130 | 1 | 0.536 |
EPHA5 |
0.626 | 0.104 | 2 | 0.682 |
PDGFRA |
0.626 | -0.096 | 3 | 0.673 |
WEE1_TYR |
0.625 | -0.049 | -1 | 0.638 |
PTK2B |
0.625 | 0.040 | -1 | 0.669 |
JAK1 |
0.624 | -0.085 | 1 | 0.496 |
TNNI3K_TYR |
0.624 | -0.110 | 1 | 0.593 |
KIT |
0.624 | -0.090 | 3 | 0.654 |
STLK3 |
0.623 | -0.075 | 1 | 0.513 |
NTRK1 |
0.623 | -0.057 | -1 | 0.608 |
FRK |
0.621 | 0.056 | -1 | 0.672 |
EPHA3 |
0.621 | -0.002 | 2 | 0.663 |
FGR |
0.620 | -0.131 | 1 | 0.543 |
YANK3 |
0.620 | -0.063 | 2 | 0.334 |
KDR |
0.619 | -0.126 | 3 | 0.619 |
LYN |
0.618 | 0.003 | 3 | 0.595 |
NTRK2 |
0.617 | -0.096 | 3 | 0.619 |
FYN |
0.617 | 0.003 | -1 | 0.597 |
MET |
0.616 | -0.104 | 3 | 0.657 |
FGFR3 |
0.616 | -0.090 | 3 | 0.631 |
DDR2 |
0.616 | -0.064 | 3 | 0.598 |
MATK |
0.616 | -0.057 | -1 | 0.578 |
EPHA8 |
0.615 | 0.011 | -1 | 0.580 |
INSR |
0.614 | -0.092 | 3 | 0.615 |
NTRK3 |
0.614 | -0.077 | -1 | 0.583 |
CSK |
0.613 | -0.059 | 2 | 0.681 |
ERBB2 |
0.611 | -0.118 | 1 | 0.513 |
FLT4 |
0.611 | -0.145 | 3 | 0.623 |
EPHA2 |
0.610 | 0.014 | -1 | 0.575 |
EGFR |
0.609 | -0.060 | 1 | 0.461 |
FGFR4 |
0.607 | -0.066 | -1 | 0.580 |
SRC |
0.606 | -0.051 | -1 | 0.610 |
FLT1 |
0.605 | -0.163 | -1 | 0.554 |
MUSK |
0.601 | -0.100 | 1 | 0.422 |
SYK |
0.601 | 0.002 | -1 | 0.503 |
FES |
0.601 | -0.002 | -1 | 0.635 |
IGF1R |
0.599 | -0.086 | 3 | 0.564 |
PTK2 |
0.596 | -0.075 | -1 | 0.492 |
CK1A |
0.593 | -0.131 | -3 | 0.232 |
ERBB4 |
0.587 | -0.085 | 1 | 0.493 |
CK1G3 |
0.585 | -0.105 | -3 | 0.187 |
YANK2 |
0.578 | -0.105 | 2 | 0.346 |
ZAP70 |
0.571 | -0.090 | -1 | 0.484 |
CK1G2 |
0.551 | -0.138 | -3 | 0.280 |