Motif 593 (n=70)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14727 | APAF1 | S268 | psp | Apoptotic protease-activating factor 1 (APAF-1) | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}. |
| O43399 | TPD52L2 | S166 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43561 | LAT | S209 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60563 | CCNT1 | S495 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O94806 | PRKD3 | S731 | ochoa|psp | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O95466 | FMNL1 | S685 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| P09651 | HNRNPA1 | S22 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0DMV8 | HSPA1A | S362 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S362 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10909 | CLU | S391 | ochoa | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17407782, PubMed:17412999). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex (PubMed:2780565, PubMed:1903064, PubMed:2601725, PubMed:2721499, PubMed:1551440, PubMed:9200695, PubMed:34667172). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:1903064, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2601725, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:9200695}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}. |
| P11142 | HSPA8 | S362 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P16615 | ATP2A2 | S170 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P17612 | PRKACA | S140 | ochoa|psp | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P20929 | NEB | S437 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P22626 | HNRNPA2B1 | S29 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P22694 | PRKACB | S140 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P32248 | CCR7 | S356 | psp | C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) | Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. |
| P34931 | HSPA1L | S364 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P37275 | ZEB1 | S521 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P46100 | ATRX | S871 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49792 | RANBP2 | S1160 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51991 | HNRNPA3 | S43 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P55327 | TPD52 | S176 | psp | Tumor protein D52 (Protein N8) | None |
| P62937 | PPIA | S21 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| Q00536 | CDK16 | S391 | psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q05682 | CALD1 | S518 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q09666 | AHNAK | S4993 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13887 | KLF5 | S153 | psp | Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) | Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. |
| Q14667 | BLTP2 | S2094 | ochoa | Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) | Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}. |
| Q15139 | PRKD1 | S738 | ochoa|psp | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15723 | ELF2 | S304 | ochoa | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation. |
| Q16623 | STX1A | S95 | ochoa | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
| Q16891 | IMMT | S584 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q32P51 | HNRNPA1L2 | S22 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q3KQU3 | MAP7D1 | S809 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KR37 | GRAMD1B | S281 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q5UIP0 | RIF1 | S782 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUB5 | FAM171A1 | S460 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q71U36 | TUBA1A | S165 | psp | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7KZI7 | MARK2 | S365 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z6Z7 | HUWE1 | S3565 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86V21 | AACS | S74 | ochoa | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}. |
| Q8IVF2 | AHNAK2 | S693 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S851 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1181 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1676 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2006 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2336 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2666 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2996 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S3986 | ochoa | Protein AHNAK2 | None |
| Q8N3X1 | FNBP4 | S508 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NB50 | ZFP62 | S233 | ochoa | Zinc finger protein 62 homolog (Zfp-62) | May play a role in differentiating skeletal muscle. {ECO:0000250}. |
| Q8NB50 | ZFP62 | S345 | ochoa | Zinc finger protein 62 homolog (Zfp-62) | May play a role in differentiating skeletal muscle. {ECO:0000250}. |
| Q8WWY3 | PRPF31 | S439 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92499 | DDX1 | S700 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q96PL5 | ERMAP | S418 | ochoa | Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen) | Possible role as a cell-adhesion or receptor molecule of erythroid cells. |
| Q96PY6 | NEK1 | S806 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q9BQE3 | TUBA1C | S165 | psp | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BZL6 | PRKD2 | S706 | ochoa|psp | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9ULH0 | KIDINS220 | S1555 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S144 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9Y4B5 | MTCL1 | S542 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| A0A2R8Y4L2 | HNRNPA1L3 | S22 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| Q9BRA2 | TXNDC17 | S41 | Sugiyama | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}. |
| P49585 | PCYT1A | S174 | Sugiyama | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
| Q9Y5K3 | PCYT1B | S174 | Sugiyama | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q8TEQ6 | GEMIN5 | S1396 | Sugiyama | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q13085 | ACACA | S1238 | EPSD | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| O14893 | GEMIN2 | S126 | Sugiyama | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.315016e-08 | 7.881 |
| R-HSA-2262752 | Cellular responses to stress | 1.784237e-07 | 6.749 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 5.075317e-07 | 6.295 |
| R-HSA-163685 | Integration of energy metabolism | 2.367005e-06 | 5.626 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.593014e-06 | 5.338 |
| R-HSA-9833482 | PKR-mediated signaling | 1.049945e-05 | 4.979 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 1.348609e-05 | 4.870 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.085302e-05 | 4.294 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 7.056478e-05 | 4.151 |
| R-HSA-111933 | Calmodulin induced events | 1.035814e-04 | 3.985 |
| R-HSA-111997 | CaM pathway | 1.035814e-04 | 3.985 |
| R-HSA-8853659 | RET signaling | 1.035814e-04 | 3.985 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.248388e-04 | 3.904 |
| R-HSA-8963896 | HDL assembly | 1.476004e-04 | 3.831 |
| R-HSA-111996 | Ca-dependent events | 1.838769e-04 | 3.735 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.008610e-04 | 3.697 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.062385e-04 | 3.686 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.292374e-04 | 3.640 |
| R-HSA-163615 | PKA activation | 3.018528e-04 | 3.520 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.018528e-04 | 3.520 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.104560e-04 | 3.508 |
| R-HSA-392517 | Rap1 signalling | 3.415977e-04 | 3.466 |
| R-HSA-422356 | Regulation of insulin secretion | 3.679598e-04 | 3.434 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.995212e-04 | 3.398 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 4.308651e-04 | 3.366 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.330866e-04 | 3.363 |
| R-HSA-112043 | PLC beta mediated events | 6.158412e-04 | 3.211 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.467576e-04 | 3.189 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 6.514334e-04 | 3.186 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 6.514334e-04 | 3.186 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 7.587462e-04 | 3.120 |
| R-HSA-112040 | G-protein mediated events | 8.383358e-04 | 3.077 |
| R-HSA-180024 | DARPP-32 events | 1.014088e-03 | 2.994 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.270452e-03 | 2.896 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.483974e-03 | 2.829 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.755524e-03 | 2.756 |
| R-HSA-163560 | Triglyceride catabolism | 1.821719e-03 | 2.740 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.874815e-03 | 2.727 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.061499e-03 | 2.686 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.632296e-03 | 2.580 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.632296e-03 | 2.580 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.632296e-03 | 2.580 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.785712e-03 | 2.555 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.278655e-03 | 2.484 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.278655e-03 | 2.484 |
| R-HSA-449147 | Signaling by Interleukins | 3.042951e-03 | 2.517 |
| R-HSA-70171 | Glycolysis | 3.461505e-03 | 2.461 |
| R-HSA-9634597 | GPER1 signaling | 3.821885e-03 | 2.418 |
| R-HSA-111885 | Opioid Signalling | 3.922304e-03 | 2.406 |
| R-HSA-196780 | Biotin transport and metabolism | 5.092491e-03 | 2.293 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.562520e-03 | 2.341 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.267144e-03 | 2.203 |
| R-HSA-191859 | snRNP Assembly | 6.267144e-03 | 2.203 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.416132e-03 | 2.193 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 5.622524e-03 | 2.250 |
| R-HSA-112316 | Neuronal System | 5.765401e-03 | 2.239 |
| R-HSA-8979227 | Triglyceride metabolism | 6.267144e-03 | 2.203 |
| R-HSA-70326 | Glucose metabolism | 6.179969e-03 | 2.209 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.859522e-03 | 2.232 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.526181e-03 | 2.185 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.711990e-03 | 2.173 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 6.754839e-03 | 2.170 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.791524e-03 | 2.168 |
| R-HSA-72172 | mRNA Splicing | 8.237999e-03 | 2.084 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 8.629824e-03 | 2.064 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 7.356571e-03 | 2.133 |
| R-HSA-8953854 | Metabolism of RNA | 7.588200e-03 | 2.120 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 7.356571e-03 | 2.133 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.341274e-03 | 2.134 |
| R-HSA-194138 | Signaling by VEGF | 7.766353e-03 | 2.110 |
| R-HSA-913531 | Interferon Signaling | 7.192541e-03 | 2.143 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.013633e-02 | 1.994 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.099365e-02 | 1.959 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.099365e-02 | 1.959 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.099365e-02 | 1.959 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.099365e-02 | 1.959 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.099365e-02 | 1.959 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.144801e-02 | 1.941 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.220763e-02 | 1.913 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.307409e-02 | 1.884 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.268310e-02 | 1.897 |
| R-HSA-422475 | Axon guidance | 1.320272e-02 | 1.879 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.461452e-02 | 1.835 |
| R-HSA-168256 | Immune System | 1.544227e-02 | 1.811 |
| R-HSA-109582 | Hemostasis | 1.347813e-02 | 1.870 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.513200e-02 | 1.820 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.545866e-02 | 1.811 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 1.644558e-02 | 1.784 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.690276e-02 | 1.772 |
| R-HSA-9663891 | Selective autophagy | 1.690276e-02 | 1.772 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.720820e-02 | 1.764 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.811311e-02 | 1.742 |
| R-HSA-9675108 | Nervous system development | 1.860382e-02 | 1.730 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.927287e-02 | 1.715 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.998202e-02 | 1.699 |
| R-HSA-190861 | Gap junction assembly | 2.192809e-02 | 1.659 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.394946e-02 | 1.621 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.625420e-02 | 1.581 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.987541e-02 | 1.525 |
| R-HSA-68877 | Mitotic Prometaphase | 3.036178e-02 | 1.518 |
| R-HSA-9646399 | Aggrephagy | 2.821070e-02 | 1.550 |
| R-HSA-190828 | Gap junction trafficking | 3.392843e-02 | 1.469 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.711864e-02 | 1.567 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.044696e-02 | 1.516 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.504630e-02 | 1.455 |
| R-HSA-373760 | L1CAM interactions | 3.577637e-02 | 1.446 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.308455e-02 | 1.480 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.991511e-02 | 1.524 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.633163e-02 | 1.440 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.755726e-02 | 1.425 |
| R-HSA-437239 | Recycling pathway of L1 | 3.755726e-02 | 1.425 |
| R-HSA-1483191 | Synthesis of PC | 3.755726e-02 | 1.425 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 3.795770e-02 | 1.421 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 3.795770e-02 | 1.421 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 3.795770e-02 | 1.421 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 3.795770e-02 | 1.421 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 3.795770e-02 | 1.421 |
| R-HSA-5620924 | Intraflagellar transport | 3.879863e-02 | 1.411 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.929556e-02 | 1.406 |
| R-HSA-164525 | Plus-strand DNA synthesis | 4.326262e-02 | 1.364 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 4.326262e-02 | 1.364 |
| R-HSA-162585 | Uncoating of the HIV Virion | 4.853863e-02 | 1.314 |
| R-HSA-114516 | Disinhibition of SNARE formation | 5.378586e-02 | 1.269 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 5.900448e-02 | 1.229 |
| R-HSA-164516 | Minus-strand DNA synthesis | 5.900448e-02 | 1.229 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.917174e-02 | 1.228 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.917174e-02 | 1.228 |
| R-HSA-166665 | Terminal pathway of complement | 4.326262e-02 | 1.364 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.523441e-02 | 1.345 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.004648e-02 | 1.301 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.939525e-02 | 1.226 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.064578e-02 | 1.295 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.771807e-02 | 1.239 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.791182e-02 | 1.320 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.771807e-02 | 1.239 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 5.378586e-02 | 1.269 |
| R-HSA-397014 | Muscle contraction | 4.012919e-02 | 1.397 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 4.326262e-02 | 1.364 |
| R-HSA-447041 | CHL1 interactions | 5.378586e-02 | 1.269 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.374269e-02 | 1.359 |
| R-HSA-6798695 | Neutrophil degranulation | 4.946788e-02 | 1.306 |
| R-HSA-5578775 | Ion homeostasis | 4.927183e-02 | 1.307 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.656595e-02 | 1.332 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.148875e-02 | 1.382 |
| R-HSA-983189 | Kinesins | 5.484940e-02 | 1.261 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.005553e-02 | 1.397 |
| R-HSA-1632852 | Macroautophagy | 5.763795e-02 | 1.239 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.771807e-02 | 1.239 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.360785e-02 | 1.196 |
| R-HSA-170984 | ARMS-mediated activation | 6.419464e-02 | 1.193 |
| R-HSA-9613354 | Lipophagy | 6.419464e-02 | 1.193 |
| R-HSA-2025928 | Calcineurin activates NFAT | 6.419464e-02 | 1.193 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 6.419464e-02 | 1.193 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 6.419464e-02 | 1.193 |
| R-HSA-173107 | Binding and entry of HIV virion | 6.935649e-02 | 1.159 |
| R-HSA-111458 | Formation of apoptosome | 6.935649e-02 | 1.159 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 6.935649e-02 | 1.159 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 6.935649e-02 | 1.159 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.437443e-02 | 1.129 |
| R-HSA-380287 | Centrosome maturation | 7.755131e-02 | 1.110 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 7.959588e-02 | 1.099 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.043848e-01 | 0.981 |
| R-HSA-3928664 | Ephrin signaling | 1.194513e-01 | 0.923 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.291455e-01 | 0.889 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.339530e-01 | 0.873 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 7.959588e-02 | 1.099 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.194513e-01 | 0.923 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.194513e-01 | 0.923 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.194513e-01 | 0.923 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.194513e-01 | 0.923 |
| R-HSA-162587 | HIV Life Cycle | 7.336249e-02 | 1.135 |
| R-HSA-391251 | Protein folding | 1.096666e-01 | 0.960 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 7.959588e-02 | 1.099 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 7.959588e-02 | 1.099 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.194513e-01 | 0.923 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.339530e-01 | 0.873 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.235272e-02 | 1.035 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.043848e-01 | 0.981 |
| R-HSA-5617833 | Cilium Assembly | 1.097629e-01 | 0.960 |
| R-HSA-169893 | Prolonged ERK activation events | 1.047096e-01 | 0.980 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.096504e-01 | 0.960 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.280227e-02 | 1.138 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.033943e-02 | 1.095 |
| R-HSA-9609690 | HCMV Early Events | 1.168012e-01 | 0.933 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.243117e-01 | 0.905 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.917637e-02 | 1.004 |
| R-HSA-5682910 | LGI-ADAM interactions | 7.449018e-02 | 1.128 |
| R-HSA-9697154 | Disorders of Nervous System Development | 8.467372e-02 | 1.072 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 8.467372e-02 | 1.072 |
| R-HSA-9005895 | Pervasive developmental disorders | 8.467372e-02 | 1.072 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.047096e-01 | 0.980 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.197191e-01 | 0.922 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.186227e-01 | 0.926 |
| R-HSA-9612973 | Autophagy | 7.238910e-02 | 1.140 |
| R-HSA-69275 | G2/M Transition | 1.051666e-01 | 0.978 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.096504e-01 | 0.960 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.186227e-01 | 0.926 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.074550e-01 | 0.969 |
| R-HSA-68886 | M Phase | 7.299538e-02 | 1.137 |
| R-HSA-418594 | G alpha (i) signalling events | 8.888350e-02 | 1.051 |
| R-HSA-162592 | Integration of provirus | 7.959588e-02 | 1.099 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 9.474645e-02 | 1.023 |
| R-HSA-1433559 | Regulation of KIT signaling | 9.474645e-02 | 1.023 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.243117e-01 | 0.905 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 1.291455e-01 | 0.889 |
| R-HSA-8876725 | Protein methylation | 9.974164e-02 | 1.001 |
| R-HSA-418555 | G alpha (s) signalling events | 8.865331e-02 | 1.052 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.186227e-01 | 0.926 |
| R-HSA-210991 | Basigin interactions | 1.339530e-01 | 0.873 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.078676e-02 | 1.042 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.078676e-02 | 1.042 |
| R-HSA-9824446 | Viral Infection Pathways | 1.017394e-01 | 0.993 |
| R-HSA-5663205 | Infectious disease | 8.744469e-02 | 1.058 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.124118e-02 | 1.147 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.437443e-02 | 1.129 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.387342e-01 | 0.858 |
| R-HSA-449836 | Other interleukin signaling | 1.243117e-01 | 0.905 |
| R-HSA-1280218 | Adaptive Immune System | 1.350541e-01 | 0.869 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.049249e-02 | 1.094 |
| R-HSA-168249 | Innate Immune System | 1.249320e-01 | 0.903 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.567590e-02 | 1.067 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.389258e-01 | 0.857 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.755131e-02 | 1.110 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.389015e-01 | 0.857 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.865331e-02 | 1.052 |
| R-HSA-428157 | Sphingolipid metabolism | 1.227937e-01 | 0.911 |
| R-HSA-556833 | Metabolism of lipids | 1.272512e-01 | 0.895 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.409410e-01 | 0.851 |
| R-HSA-68882 | Mitotic Anaphase | 1.426958e-01 | 0.846 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.434893e-01 | 0.843 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.434893e-01 | 0.843 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 1.434893e-01 | 0.843 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.439743e-01 | 0.842 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.459641e-01 | 0.836 |
| R-HSA-200425 | Carnitine shuttle | 1.482185e-01 | 0.829 |
| R-HSA-74182 | Ketone body metabolism | 1.482185e-01 | 0.829 |
| R-HSA-3000170 | Syndecan interactions | 1.482185e-01 | 0.829 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.529218e-01 | 0.816 |
| R-HSA-162906 | HIV Infection | 1.569661e-01 | 0.804 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.575994e-01 | 0.802 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.582852e-01 | 0.801 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.622516e-01 | 0.790 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.668783e-01 | 0.778 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.668783e-01 | 0.778 |
| R-HSA-8949613 | Cristae formation | 1.668783e-01 | 0.778 |
| R-HSA-264876 | Insulin processing | 1.668783e-01 | 0.778 |
| R-HSA-68875 | Mitotic Prophase | 1.696499e-01 | 0.770 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.714797e-01 | 0.766 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.714797e-01 | 0.766 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.755361e-01 | 0.756 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.760560e-01 | 0.754 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.760560e-01 | 0.754 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.806073e-01 | 0.743 |
| R-HSA-2424491 | DAP12 signaling | 1.806073e-01 | 0.743 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.806073e-01 | 0.743 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.851338e-01 | 0.733 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.851338e-01 | 0.733 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.851338e-01 | 0.733 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.851338e-01 | 0.733 |
| R-HSA-114608 | Platelet degranulation | 1.854179e-01 | 0.732 |
| R-HSA-9609646 | HCMV Infection | 1.881279e-01 | 0.726 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.896355e-01 | 0.722 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.941127e-01 | 0.712 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.941127e-01 | 0.712 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.941127e-01 | 0.712 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.941127e-01 | 0.712 |
| R-HSA-5576891 | Cardiac conduction | 1.953787e-01 | 0.709 |
| R-HSA-9843745 | Adipogenesis | 1.953787e-01 | 0.709 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.973793e-01 | 0.705 |
| R-HSA-390522 | Striated Muscle Contraction | 1.985654e-01 | 0.702 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.985654e-01 | 0.702 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.985654e-01 | 0.702 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.029937e-01 | 0.693 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.029937e-01 | 0.693 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.073979e-01 | 0.683 |
| R-HSA-187687 | Signalling to ERKs | 2.073979e-01 | 0.683 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.073979e-01 | 0.683 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.117780e-01 | 0.674 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.117780e-01 | 0.674 |
| R-HSA-9679506 | SARS-CoV Infections | 2.137731e-01 | 0.670 |
| R-HSA-1640170 | Cell Cycle | 2.158281e-01 | 0.666 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.161341e-01 | 0.665 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.161341e-01 | 0.665 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.204665e-01 | 0.657 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.247478e-01 | 0.648 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.247752e-01 | 0.648 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.247752e-01 | 0.648 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.247752e-01 | 0.648 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.247752e-01 | 0.648 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.290603e-01 | 0.640 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.290603e-01 | 0.640 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.290603e-01 | 0.640 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.290603e-01 | 0.640 |
| R-HSA-202433 | Generation of second messenger molecules | 2.290603e-01 | 0.640 |
| R-HSA-167169 | HIV Transcription Elongation | 2.290603e-01 | 0.640 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.290603e-01 | 0.640 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.290603e-01 | 0.640 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.317200e-01 | 0.635 |
| R-HSA-9658195 | Leishmania infection | 2.323557e-01 | 0.634 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.323557e-01 | 0.634 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.333220e-01 | 0.632 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.378278e-01 | 0.624 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.417756e-01 | 0.617 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.459678e-01 | 0.609 |
| R-HSA-2172127 | DAP12 interactions | 2.501371e-01 | 0.602 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.542836e-01 | 0.595 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.584074e-01 | 0.588 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 2.584074e-01 | 0.588 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.665875e-01 | 0.574 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.694797e-01 | 0.569 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 2.706440e-01 | 0.568 |
| R-HSA-2514856 | The phototransduction cascade | 2.786906e-01 | 0.555 |
| R-HSA-72306 | tRNA processing | 2.807317e-01 | 0.552 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.826810e-01 | 0.549 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.826810e-01 | 0.549 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.826810e-01 | 0.549 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.826810e-01 | 0.549 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.866495e-01 | 0.543 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.866495e-01 | 0.543 |
| R-HSA-1266738 | Developmental Biology | 2.895952e-01 | 0.538 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.909449e-01 | 0.536 |
| R-HSA-418597 | G alpha (z) signalling events | 2.945214e-01 | 0.531 |
| R-HSA-8957322 | Metabolism of steroids | 2.963195e-01 | 0.528 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.984252e-01 | 0.525 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.984252e-01 | 0.525 |
| R-HSA-168255 | Influenza Infection | 2.991043e-01 | 0.524 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.138276e-01 | 0.503 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.138276e-01 | 0.503 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.176257e-01 | 0.498 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.288956e-01 | 0.483 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.341082e-01 | 0.476 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.416434e-01 | 0.466 |
| R-HSA-167172 | Transcription of the HIV genome | 3.436364e-01 | 0.464 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.436364e-01 | 0.464 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.456590e-01 | 0.461 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 3.476640e-01 | 0.459 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.508862e-01 | 0.455 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.508862e-01 | 0.455 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.508862e-01 | 0.455 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.580569e-01 | 0.446 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.616128e-01 | 0.442 |
| R-HSA-4086398 | Ca2+ pathway | 3.616128e-01 | 0.442 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.651492e-01 | 0.438 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.686663e-01 | 0.433 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.686663e-01 | 0.433 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.695812e-01 | 0.432 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.791023e-01 | 0.421 |
| R-HSA-4086400 | PCP/CE pathway | 3.791023e-01 | 0.421 |
| R-HSA-9659379 | Sensory processing of sound | 3.825429e-01 | 0.417 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.859647e-01 | 0.413 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.927521e-01 | 0.406 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.027943e-01 | 0.395 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 4.028780e-01 | 0.395 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.061050e-01 | 0.391 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.061050e-01 | 0.391 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.093977e-01 | 0.388 |
| R-HSA-70268 | Pyruvate metabolism | 4.126722e-01 | 0.384 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.255920e-01 | 0.371 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.319461e-01 | 0.365 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.382306e-01 | 0.358 |
| R-HSA-388396 | GPCR downstream signalling | 4.495452e-01 | 0.347 |
| R-HSA-157579 | Telomere Maintenance | 4.505943e-01 | 0.346 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.505943e-01 | 0.346 |
| R-HSA-190236 | Signaling by FGFR | 4.536429e-01 | 0.343 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.596901e-01 | 0.338 |
| R-HSA-418346 | Platelet homeostasis | 4.803386e-01 | 0.318 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.832240e-01 | 0.316 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.832240e-01 | 0.316 |
| R-HSA-211000 | Gene Silencing by RNA | 4.832240e-01 | 0.316 |
| R-HSA-202403 | TCR signaling | 4.917854e-01 | 0.308 |
| R-HSA-6803157 | Antimicrobial peptides | 4.946080e-01 | 0.306 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.974150e-01 | 0.303 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.974150e-01 | 0.303 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.990988e-01 | 0.302 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.002066e-01 | 0.301 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.055452e-01 | 0.296 |
| R-HSA-199991 | Membrane Trafficking | 5.084183e-01 | 0.294 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.112205e-01 | 0.291 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.166372e-01 | 0.287 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.166372e-01 | 0.287 |
| R-HSA-1643685 | Disease | 5.183098e-01 | 0.285 |
| R-HSA-1483257 | Phospholipid metabolism | 5.216080e-01 | 0.283 |
| R-HSA-73886 | Chromosome Maintenance | 5.272930e-01 | 0.278 |
| R-HSA-372790 | Signaling by GPCR | 5.376011e-01 | 0.270 |
| R-HSA-977606 | Regulation of Complement cascade | 5.377165e-01 | 0.269 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.479126e-01 | 0.261 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.724405e-01 | 0.242 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.724405e-01 | 0.242 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.748196e-01 | 0.240 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.888223e-01 | 0.230 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.911113e-01 | 0.228 |
| R-HSA-166658 | Complement cascade | 5.956517e-01 | 0.225 |
| R-HSA-2187338 | Visual phototransduction | 6.001421e-01 | 0.222 |
| R-HSA-166520 | Signaling by NTRKs | 6.023689e-01 | 0.220 |
| R-HSA-9609507 | Protein localization | 6.133198e-01 | 0.212 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.133198e-01 | 0.212 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.176162e-01 | 0.209 |
| R-HSA-9610379 | HCMV Late Events | 6.218654e-01 | 0.206 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.239725e-01 | 0.205 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.281518e-01 | 0.202 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.295370e-01 | 0.201 |
| R-HSA-109581 | Apoptosis | 6.322852e-01 | 0.199 |
| R-HSA-5619102 | SLC transporter disorders | 6.424210e-01 | 0.192 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.561486e-01 | 0.183 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.561486e-01 | 0.183 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.571194e-01 | 0.182 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.781844e-01 | 0.169 |
| R-HSA-375276 | Peptide ligand-binding receptors | 6.802745e-01 | 0.167 |
| R-HSA-983712 | Ion channel transport | 6.855998e-01 | 0.164 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.976869e-01 | 0.156 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.062220e-01 | 0.151 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.093143e-01 | 0.149 |
| R-HSA-5357801 | Programmed Cell Death | 7.141610e-01 | 0.146 |
| R-HSA-418990 | Adherens junctions interactions | 7.342568e-01 | 0.134 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.459222e-01 | 0.127 |
| R-HSA-8939211 | ESR-mediated signaling | 7.611395e-01 | 0.119 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.611395e-01 | 0.119 |
| R-HSA-157118 | Signaling by NOTCH | 7.651308e-01 | 0.116 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.741894e-01 | 0.111 |
| R-HSA-421270 | Cell-cell junction organization | 7.792097e-01 | 0.108 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.877311e-01 | 0.104 |
| R-HSA-416476 | G alpha (q) signalling events | 7.947757e-01 | 0.100 |
| R-HSA-446728 | Cell junction organization | 8.103268e-01 | 0.091 |
| R-HSA-382551 | Transport of small molecules | 8.115783e-01 | 0.091 |
| R-HSA-162582 | Signal Transduction | 8.165346e-01 | 0.088 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.217230e-01 | 0.085 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.286198e-01 | 0.082 |
| R-HSA-195721 | Signaling by WNT | 8.305414e-01 | 0.081 |
| R-HSA-1500931 | Cell-Cell communication | 8.469045e-01 | 0.072 |
| R-HSA-1474244 | Extracellular matrix organization | 8.593392e-01 | 0.066 |
| R-HSA-1430728 | Metabolism | 8.605067e-01 | 0.065 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.670687e-01 | 0.062 |
| R-HSA-73894 | DNA Repair | 8.806157e-01 | 0.055 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.826261e-01 | 0.054 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.998470e-01 | 0.046 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.020938e-01 | 0.045 |
| R-HSA-8978868 | Fatty acid metabolism | 9.090574e-01 | 0.041 |
| R-HSA-5668914 | Diseases of metabolism | 9.188256e-01 | 0.037 |
| R-HSA-212436 | Generic Transcription Pathway | 9.429710e-01 | 0.026 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.508488e-01 | 0.022 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.665954e-01 | 0.015 |
| R-HSA-500792 | GPCR ligand binding | 9.678370e-01 | 0.014 |
| R-HSA-74160 | Gene expression (Transcription) | 9.706045e-01 | 0.013 |
| R-HSA-597592 | Post-translational protein modification | 9.865543e-01 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 9.938695e-01 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 9.949722e-01 | 0.002 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.755 | 0.235 | 1 | 0.722 |
FAM20C |
0.752 | 0.361 | 2 | 0.873 |
COT |
0.751 | 0.118 | 2 | 0.744 |
CAMK2D |
0.748 | 0.178 | -3 | 0.691 |
PKN3 |
0.747 | 0.169 | -3 | 0.667 |
MTOR |
0.746 | 0.060 | 1 | 0.782 |
NEK6 |
0.746 | 0.117 | -2 | 0.800 |
TBK1 |
0.743 | 0.112 | 1 | 0.787 |
CHAK2 |
0.743 | 0.307 | -1 | 0.693 |
MNK2 |
0.743 | 0.209 | -2 | 0.752 |
CAMK2G |
0.742 | 0.110 | 2 | 0.694 |
WNK1 |
0.742 | 0.196 | -2 | 0.805 |
PKCD |
0.742 | 0.172 | 2 | 0.646 |
CAMK2B |
0.741 | 0.160 | 2 | 0.738 |
MST4 |
0.741 | 0.134 | 2 | 0.692 |
PRKD2 |
0.741 | 0.125 | -3 | 0.630 |
IKKB |
0.741 | 0.032 | -2 | 0.648 |
DSTYK |
0.741 | 0.073 | 2 | 0.773 |
ULK2 |
0.741 | 0.082 | 2 | 0.613 |
IKKE |
0.741 | 0.061 | 1 | 0.778 |
SRPK1 |
0.741 | 0.121 | -3 | 0.590 |
RSK2 |
0.740 | 0.067 | -3 | 0.631 |
PIM3 |
0.740 | 0.077 | -3 | 0.672 |
NEK7 |
0.740 | 0.084 | -3 | 0.714 |
PRKD1 |
0.740 | 0.099 | -3 | 0.672 |
GCN2 |
0.740 | -0.025 | 2 | 0.624 |
PDHK4 |
0.738 | 0.049 | 1 | 0.801 |
LATS2 |
0.738 | 0.133 | -5 | 0.651 |
NDR2 |
0.738 | 0.074 | -3 | 0.695 |
P90RSK |
0.737 | 0.051 | -3 | 0.633 |
RAF1 |
0.736 | 0.023 | 1 | 0.793 |
MAPKAPK3 |
0.735 | 0.052 | -3 | 0.624 |
PRPK |
0.735 | 0.008 | -1 | 0.533 |
PKN2 |
0.735 | 0.101 | -3 | 0.683 |
CDC7 |
0.735 | -0.007 | 1 | 0.689 |
ULK1 |
0.734 | 0.050 | -3 | 0.655 |
RSK3 |
0.734 | 0.057 | -3 | 0.609 |
PDHK1 |
0.734 | -0.008 | 1 | 0.812 |
PKACG |
0.734 | 0.114 | -2 | 0.697 |
IKKA |
0.733 | 0.083 | -2 | 0.626 |
SRPK2 |
0.733 | 0.096 | -3 | 0.519 |
RIPK3 |
0.733 | 0.133 | 3 | 0.632 |
CAMK2A |
0.733 | 0.091 | 2 | 0.702 |
PIM1 |
0.733 | 0.090 | -3 | 0.617 |
MNK1 |
0.732 | 0.180 | -2 | 0.745 |
NDR1 |
0.732 | 0.062 | -3 | 0.687 |
PAK6 |
0.732 | 0.079 | -2 | 0.665 |
CAMK1B |
0.732 | 0.036 | -3 | 0.690 |
BCKDK |
0.732 | -0.021 | -1 | 0.443 |
CDKL1 |
0.732 | 0.048 | -3 | 0.633 |
P70S6KB |
0.731 | 0.061 | -3 | 0.643 |
MARK4 |
0.731 | 0.074 | 4 | 0.632 |
NUAK2 |
0.731 | 0.047 | -3 | 0.686 |
NLK |
0.731 | 0.046 | 1 | 0.780 |
TGFBR2 |
0.730 | 0.016 | -2 | 0.722 |
PKCA |
0.730 | 0.116 | 2 | 0.602 |
CLK1 |
0.730 | 0.112 | -3 | 0.601 |
PHKG1 |
0.730 | 0.090 | -3 | 0.681 |
AURC |
0.729 | 0.104 | -2 | 0.620 |
PKCZ |
0.729 | 0.191 | 2 | 0.633 |
RSK4 |
0.729 | 0.089 | -3 | 0.610 |
LATS1 |
0.729 | 0.203 | -3 | 0.727 |
BMPR2 |
0.729 | -0.013 | -2 | 0.790 |
NEK9 |
0.729 | 0.051 | 2 | 0.662 |
MAPKAPK2 |
0.729 | 0.042 | -3 | 0.576 |
SKMLCK |
0.729 | 0.137 | -2 | 0.772 |
CLK2 |
0.728 | 0.139 | -3 | 0.590 |
ATR |
0.728 | -0.005 | 1 | 0.760 |
CDK13 |
0.728 | 0.091 | 1 | 0.607 |
AMPKA1 |
0.728 | 0.084 | -3 | 0.700 |
NEK2 |
0.728 | 0.102 | 2 | 0.638 |
NIK |
0.728 | 0.082 | -3 | 0.715 |
CLK4 |
0.727 | 0.099 | -3 | 0.619 |
MLK1 |
0.727 | -0.001 | 2 | 0.666 |
AMPKA2 |
0.727 | 0.077 | -3 | 0.675 |
ANKRD3 |
0.726 | 0.136 | 1 | 0.834 |
ICK |
0.726 | 0.066 | -3 | 0.672 |
DNAPK |
0.726 | 0.080 | 1 | 0.737 |
CAMK4 |
0.726 | 0.047 | -3 | 0.667 |
HIPK4 |
0.725 | 0.058 | 1 | 0.707 |
PRP4 |
0.725 | 0.235 | -3 | 0.822 |
PKCG |
0.725 | 0.073 | 2 | 0.608 |
PLK1 |
0.725 | 0.071 | -2 | 0.762 |
CDKL5 |
0.725 | 0.027 | -3 | 0.632 |
MSK2 |
0.725 | 0.030 | -3 | 0.577 |
WNK3 |
0.725 | 0.011 | 1 | 0.781 |
GRK1 |
0.724 | 0.033 | -2 | 0.644 |
PRKX |
0.724 | 0.110 | -3 | 0.574 |
SGK3 |
0.724 | 0.102 | -3 | 0.625 |
MSK1 |
0.724 | 0.064 | -3 | 0.584 |
CAMLCK |
0.723 | 0.027 | -2 | 0.771 |
PKCB |
0.723 | 0.082 | 2 | 0.617 |
PKCH |
0.723 | 0.084 | 2 | 0.586 |
HUNK |
0.723 | -0.011 | 2 | 0.621 |
RIPK1 |
0.723 | 0.095 | 1 | 0.798 |
CDK12 |
0.723 | 0.088 | 1 | 0.599 |
TSSK1 |
0.723 | 0.091 | -3 | 0.723 |
NUAK1 |
0.723 | 0.067 | -3 | 0.635 |
MOS |
0.723 | -0.051 | 1 | 0.701 |
PKG2 |
0.723 | 0.081 | -2 | 0.639 |
PRKD3 |
0.722 | 0.050 | -3 | 0.587 |
PAK3 |
0.722 | 0.036 | -2 | 0.716 |
CDK8 |
0.722 | 0.044 | 1 | 0.636 |
PLK3 |
0.722 | 0.066 | 2 | 0.651 |
PKACB |
0.722 | 0.072 | -2 | 0.644 |
TSSK2 |
0.722 | 0.065 | -5 | 0.747 |
MLK3 |
0.722 | 0.024 | 2 | 0.619 |
ATM |
0.722 | 0.015 | 1 | 0.728 |
CHK1 |
0.721 | 0.081 | -3 | 0.672 |
PLK4 |
0.721 | 0.125 | 2 | 0.451 |
DAPK2 |
0.721 | 0.022 | -3 | 0.714 |
MELK |
0.720 | 0.057 | -3 | 0.666 |
MLK2 |
0.720 | 0.020 | 2 | 0.658 |
AURB |
0.720 | 0.076 | -2 | 0.624 |
SRPK3 |
0.720 | 0.053 | -3 | 0.549 |
CDK9 |
0.720 | 0.078 | 1 | 0.622 |
PAK1 |
0.720 | 0.042 | -2 | 0.713 |
QSK |
0.720 | 0.035 | 4 | 0.610 |
GRK5 |
0.720 | -0.088 | -3 | 0.669 |
ERK5 |
0.720 | -0.025 | 1 | 0.684 |
DLK |
0.719 | 0.009 | 1 | 0.798 |
CDK7 |
0.719 | 0.052 | 1 | 0.620 |
DYRK2 |
0.719 | 0.067 | 1 | 0.641 |
PHKG2 |
0.718 | 0.081 | -3 | 0.658 |
IRE1 |
0.718 | 0.042 | 1 | 0.696 |
YSK4 |
0.718 | 0.025 | 1 | 0.764 |
PKCT |
0.717 | 0.087 | 2 | 0.593 |
PKCI |
0.717 | 0.123 | 2 | 0.603 |
NIM1 |
0.717 | -0.018 | 3 | 0.702 |
MASTL |
0.717 | -0.077 | -2 | 0.765 |
PKR |
0.717 | 0.155 | 1 | 0.739 |
QIK |
0.717 | -0.001 | -3 | 0.696 |
CDK19 |
0.716 | 0.036 | 1 | 0.600 |
DCAMKL2 |
0.716 | 0.118 | -3 | 0.664 |
TTBK2 |
0.716 | -0.053 | 2 | 0.554 |
GRK6 |
0.716 | -0.044 | 1 | 0.742 |
SMG1 |
0.716 | 0.009 | 1 | 0.713 |
DCAMKL1 |
0.715 | 0.112 | -3 | 0.644 |
CHAK1 |
0.715 | 0.096 | 2 | 0.577 |
PAK5 |
0.714 | 0.051 | -2 | 0.638 |
GRK4 |
0.714 | -0.090 | -2 | 0.688 |
SIK |
0.714 | 0.006 | -3 | 0.610 |
BRSK2 |
0.714 | 0.005 | -3 | 0.669 |
MLK4 |
0.713 | -0.003 | 2 | 0.603 |
MARK3 |
0.713 | 0.033 | 4 | 0.560 |
MAPKAPK5 |
0.713 | -0.027 | -3 | 0.564 |
PKACA |
0.713 | 0.061 | -2 | 0.592 |
CDK5 |
0.713 | 0.076 | 1 | 0.620 |
AKT2 |
0.713 | 0.030 | -3 | 0.549 |
MYLK4 |
0.713 | 0.039 | -2 | 0.690 |
AKT1 |
0.712 | 0.069 | -3 | 0.578 |
CDK1 |
0.712 | 0.068 | 1 | 0.572 |
WNK4 |
0.712 | 0.107 | -2 | 0.830 |
AURA |
0.712 | 0.033 | -2 | 0.585 |
KIS |
0.712 | 0.007 | 1 | 0.665 |
GRK7 |
0.711 | 0.032 | 1 | 0.683 |
PAK2 |
0.711 | 0.007 | -2 | 0.713 |
TAO3 |
0.710 | 0.115 | 1 | 0.777 |
PKCE |
0.710 | 0.098 | 2 | 0.589 |
PKN1 |
0.710 | 0.076 | -3 | 0.590 |
CAMK1G |
0.710 | 0.049 | -3 | 0.603 |
TLK2 |
0.710 | 0.012 | 1 | 0.737 |
DRAK1 |
0.710 | 0.017 | 1 | 0.733 |
MARK2 |
0.710 | 0.013 | 4 | 0.529 |
BRSK1 |
0.710 | -0.017 | -3 | 0.634 |
ALK4 |
0.710 | -0.013 | -2 | 0.730 |
CDK18 |
0.710 | 0.074 | 1 | 0.549 |
MEK1 |
0.710 | -0.042 | 2 | 0.656 |
TGFBR1 |
0.709 | 0.006 | -2 | 0.697 |
PIM2 |
0.709 | 0.025 | -3 | 0.597 |
NEK5 |
0.709 | 0.149 | 1 | 0.775 |
ALK2 |
0.708 | 0.036 | -2 | 0.701 |
HRI |
0.708 | -0.037 | -2 | 0.765 |
MARK1 |
0.708 | 0.013 | 4 | 0.589 |
VRK2 |
0.708 | 0.028 | 1 | 0.802 |
MST3 |
0.707 | 0.078 | 2 | 0.666 |
PAK4 |
0.707 | 0.032 | -2 | 0.629 |
SLK |
0.707 | 0.176 | -2 | 0.693 |
JNK2 |
0.707 | 0.052 | 1 | 0.605 |
P70S6K |
0.707 | 0.014 | -3 | 0.563 |
PERK |
0.707 | -0.016 | -2 | 0.737 |
HIPK2 |
0.706 | 0.079 | 1 | 0.565 |
P38A |
0.706 | 0.045 | 1 | 0.646 |
IRE2 |
0.706 | -0.030 | 2 | 0.576 |
ZAK |
0.706 | 0.021 | 1 | 0.817 |
TTBK1 |
0.706 | -0.026 | 2 | 0.484 |
DYRK3 |
0.705 | 0.062 | 1 | 0.663 |
CAMK1D |
0.705 | 0.054 | -3 | 0.541 |
HIPK1 |
0.705 | 0.068 | 1 | 0.653 |
DYRK1A |
0.704 | 0.034 | 1 | 0.706 |
P38B |
0.704 | 0.049 | 1 | 0.587 |
CDK3 |
0.704 | 0.066 | 1 | 0.515 |
BMPR1B |
0.703 | 0.004 | 1 | 0.623 |
MEKK1 |
0.703 | 0.011 | 1 | 0.814 |
ERK7 |
0.703 | 0.057 | 2 | 0.497 |
JNK3 |
0.703 | 0.036 | 1 | 0.628 |
ACVR2A |
0.703 | -0.038 | -2 | 0.702 |
ERK1 |
0.702 | 0.042 | 1 | 0.593 |
CDK10 |
0.702 | 0.077 | 1 | 0.584 |
IRAK4 |
0.702 | 0.086 | 1 | 0.749 |
SNRK |
0.702 | -0.092 | 2 | 0.498 |
DYRK4 |
0.702 | 0.055 | 1 | 0.578 |
BRAF |
0.702 | -0.015 | -4 | 0.736 |
CDK17 |
0.701 | 0.053 | 1 | 0.508 |
GSK3A |
0.701 | 0.067 | 4 | 0.427 |
P38G |
0.701 | 0.050 | 1 | 0.513 |
DYRK1B |
0.700 | 0.060 | 1 | 0.598 |
HIPK3 |
0.700 | 0.026 | 1 | 0.701 |
ERK2 |
0.700 | 0.033 | 1 | 0.638 |
TAO2 |
0.700 | 0.056 | 2 | 0.688 |
ACVR2B |
0.700 | -0.050 | -2 | 0.701 |
PDK1 |
0.700 | 0.125 | 1 | 0.869 |
GSK3B |
0.699 | 0.024 | 4 | 0.423 |
CDK2 |
0.699 | -0.004 | 1 | 0.639 |
CDK14 |
0.698 | 0.042 | 1 | 0.598 |
NEK8 |
0.698 | 0.040 | 2 | 0.642 |
PASK |
0.698 | 0.071 | -3 | 0.699 |
MEKK3 |
0.698 | -0.058 | 1 | 0.788 |
SGK1 |
0.698 | 0.046 | -3 | 0.477 |
MEK5 |
0.698 | -0.071 | 2 | 0.647 |
LOK |
0.698 | 0.093 | -2 | 0.739 |
TLK1 |
0.697 | -0.063 | -2 | 0.704 |
NEK4 |
0.697 | 0.058 | 1 | 0.772 |
SMMLCK |
0.696 | 0.000 | -3 | 0.655 |
SSTK |
0.696 | 0.029 | 4 | 0.620 |
MEKK2 |
0.696 | -0.010 | 2 | 0.633 |
NEK1 |
0.696 | 0.127 | 1 | 0.773 |
PINK1 |
0.696 | -0.101 | 1 | 0.696 |
AKT3 |
0.696 | 0.038 | -3 | 0.493 |
NEK11 |
0.696 | 0.049 | 1 | 0.834 |
GCK |
0.696 | 0.097 | 1 | 0.756 |
STK33 |
0.696 | 0.043 | 2 | 0.485 |
HGK |
0.695 | 0.068 | 3 | 0.787 |
KHS2 |
0.695 | 0.137 | 1 | 0.770 |
TNIK |
0.695 | 0.081 | 3 | 0.798 |
CHK2 |
0.694 | 0.024 | -3 | 0.503 |
CAMKK2 |
0.694 | 0.022 | -2 | 0.676 |
ROCK2 |
0.694 | 0.126 | -3 | 0.651 |
HPK1 |
0.694 | 0.067 | 1 | 0.769 |
MRCKB |
0.694 | 0.072 | -3 | 0.595 |
LKB1 |
0.693 | 0.062 | -3 | 0.747 |
CAMK1A |
0.693 | 0.035 | -3 | 0.502 |
MRCKA |
0.693 | 0.082 | -3 | 0.615 |
CAMKK1 |
0.693 | -0.051 | -2 | 0.676 |
CDK4 |
0.692 | 0.056 | 1 | 0.574 |
PLK2 |
0.692 | 0.014 | -3 | 0.566 |
RIPK2 |
0.691 | -0.040 | 1 | 0.824 |
P38D |
0.691 | 0.034 | 1 | 0.530 |
CDK16 |
0.691 | 0.045 | 1 | 0.518 |
MINK |
0.691 | 0.069 | 1 | 0.780 |
KHS1 |
0.691 | 0.110 | 1 | 0.773 |
NEK3 |
0.691 | 0.062 | 1 | 0.802 |
PKG1 |
0.690 | 0.026 | -2 | 0.587 |
MST2 |
0.690 | 0.013 | 1 | 0.774 |
IRAK1 |
0.690 | -0.081 | -1 | 0.492 |
CDK6 |
0.689 | 0.048 | 1 | 0.590 |
BUB1 |
0.689 | 0.089 | -5 | 0.699 |
BMPR1A |
0.689 | -0.008 | 1 | 0.614 |
YSK1 |
0.689 | 0.052 | 2 | 0.641 |
LRRK2 |
0.688 | 0.066 | 2 | 0.671 |
MST1 |
0.687 | 0.070 | 1 | 0.766 |
VRK1 |
0.687 | 0.056 | 2 | 0.640 |
MAK |
0.687 | 0.066 | -2 | 0.637 |
MAP3K15 |
0.686 | 0.042 | 1 | 0.810 |
TAK1 |
0.686 | -0.039 | 1 | 0.791 |
MPSK1 |
0.686 | -0.006 | 1 | 0.631 |
EEF2K |
0.686 | 0.004 | 3 | 0.755 |
GRK2 |
0.686 | -0.099 | -2 | 0.571 |
CK1G1 |
0.685 | -0.064 | -3 | 0.381 |
TAO1 |
0.685 | 0.080 | 1 | 0.775 |
DAPK3 |
0.685 | 0.021 | -3 | 0.648 |
MEK2 |
0.684 | -0.045 | 2 | 0.612 |
GAK |
0.684 | 0.048 | 1 | 0.667 |
SBK |
0.683 | -0.008 | -3 | 0.439 |
CK1E |
0.683 | -0.075 | -3 | 0.399 |
ROCK1 |
0.681 | 0.080 | -3 | 0.613 |
MEKK6 |
0.681 | -0.050 | 1 | 0.757 |
MOK |
0.680 | 0.036 | 1 | 0.626 |
CRIK |
0.679 | 0.068 | -3 | 0.565 |
CK2A2 |
0.678 | -0.030 | 1 | 0.472 |
DAPK1 |
0.678 | -0.005 | -3 | 0.632 |
HASPIN |
0.677 | 0.014 | -1 | 0.482 |
CK1D |
0.675 | -0.078 | -3 | 0.354 |
JNK1 |
0.675 | 0.004 | 1 | 0.562 |
OSR1 |
0.675 | 0.007 | 2 | 0.633 |
DMPK1 |
0.674 | 0.054 | -3 | 0.615 |
GRK3 |
0.673 | -0.102 | -2 | 0.524 |
CK2A1 |
0.673 | -0.023 | 1 | 0.454 |
MYO3B |
0.673 | 0.029 | 2 | 0.649 |
CK1A2 |
0.671 | -0.084 | -3 | 0.351 |
ASK1 |
0.669 | 0.023 | 1 | 0.806 |
PDHK3_TYR |
0.666 | 0.145 | 4 | 0.743 |
PBK |
0.664 | -0.057 | 1 | 0.580 |
YANK3 |
0.663 | -0.041 | 2 | 0.346 |
MYO3A |
0.663 | -0.026 | 1 | 0.753 |
ALPHAK3 |
0.662 | 0.001 | -1 | 0.493 |
LIMK2_TYR |
0.661 | 0.110 | -3 | 0.750 |
BIKE |
0.661 | -0.001 | 1 | 0.532 |
MAP2K7_TYR |
0.661 | 0.036 | 2 | 0.679 |
TESK1_TYR |
0.661 | 0.055 | 3 | 0.789 |
TTK |
0.660 | -0.020 | -2 | 0.751 |
PKMYT1_TYR |
0.659 | 0.033 | 3 | 0.756 |
PDHK4_TYR |
0.659 | 0.068 | 2 | 0.713 |
STLK3 |
0.656 | -0.060 | 1 | 0.785 |
RET |
0.656 | 0.016 | 1 | 0.800 |
PINK1_TYR |
0.655 | -0.051 | 1 | 0.765 |
JAK2 |
0.655 | 0.015 | 1 | 0.826 |
NEK10_TYR |
0.655 | 0.052 | 1 | 0.725 |
MAP2K4_TYR |
0.654 | -0.114 | -1 | 0.517 |
TYK2 |
0.652 | -0.037 | 1 | 0.804 |
BMPR2_TYR |
0.652 | -0.059 | -1 | 0.504 |
MST1R |
0.651 | -0.009 | 3 | 0.708 |
MAP2K6_TYR |
0.650 | -0.089 | -1 | 0.515 |
LIMK1_TYR |
0.650 | -0.024 | 2 | 0.673 |
CSF1R |
0.648 | -0.010 | 3 | 0.696 |
TNK1 |
0.647 | 0.068 | 3 | 0.695 |
PDHK1_TYR |
0.647 | -0.094 | -1 | 0.526 |
JAK1 |
0.647 | -0.000 | 1 | 0.811 |
DDR1 |
0.646 | -0.025 | 4 | 0.668 |
TYRO3 |
0.646 | -0.044 | 3 | 0.701 |
AAK1 |
0.646 | 0.015 | 1 | 0.426 |
EPHA6 |
0.646 | -0.058 | -1 | 0.493 |
EPHB4 |
0.645 | -0.066 | -1 | 0.485 |
JAK3 |
0.644 | -0.044 | 1 | 0.802 |
ROS1 |
0.644 | -0.074 | 3 | 0.679 |
TNNI3K_TYR |
0.643 | 0.004 | 1 | 0.797 |
ABL2 |
0.642 | -0.026 | -1 | 0.478 |
AXL |
0.641 | -0.023 | 3 | 0.668 |
FGFR2 |
0.640 | -0.052 | 3 | 0.689 |
TNK2 |
0.640 | 0.004 | 3 | 0.641 |
CK1A |
0.640 | -0.101 | -3 | 0.274 |
KIT |
0.639 | -0.047 | 3 | 0.691 |
PDGFRB |
0.639 | -0.065 | 3 | 0.695 |
EPHB1 |
0.639 | -0.083 | 1 | 0.764 |
EPHA4 |
0.639 | -0.049 | 2 | 0.659 |
EPHB3 |
0.638 | -0.073 | -1 | 0.467 |
ITK |
0.637 | -0.056 | -1 | 0.478 |
WEE1_TYR |
0.637 | -0.038 | -1 | 0.509 |
ABL1 |
0.637 | -0.059 | -1 | 0.476 |
FLT3 |
0.637 | -0.067 | 3 | 0.700 |
FGFR1 |
0.637 | -0.064 | 3 | 0.654 |
SRMS |
0.637 | -0.071 | 1 | 0.728 |
TXK |
0.636 | -0.046 | 1 | 0.665 |
TEC |
0.636 | -0.078 | -1 | 0.456 |
MERTK |
0.635 | -0.048 | 3 | 0.679 |
PDGFRA |
0.635 | -0.093 | 3 | 0.698 |
EPHA7 |
0.635 | -0.051 | 2 | 0.662 |
BMX |
0.635 | -0.051 | -1 | 0.452 |
EPHB2 |
0.635 | -0.076 | -1 | 0.467 |
TEK |
0.635 | -0.092 | 3 | 0.634 |
INSRR |
0.634 | -0.081 | 3 | 0.646 |
HCK |
0.634 | -0.101 | -1 | 0.472 |
KDR |
0.634 | -0.071 | 3 | 0.647 |
BTK |
0.633 | -0.120 | -1 | 0.472 |
PTK6 |
0.632 | -0.137 | -1 | 0.452 |
YES1 |
0.632 | -0.095 | -1 | 0.491 |
FER |
0.632 | -0.140 | 1 | 0.724 |
EPHA1 |
0.632 | -0.064 | 3 | 0.659 |
CK1G3 |
0.630 | -0.081 | -3 | 0.234 |
NTRK1 |
0.630 | -0.107 | -1 | 0.449 |
LCK |
0.630 | -0.090 | -1 | 0.474 |
YANK2 |
0.629 | -0.060 | 2 | 0.373 |
FGR |
0.629 | -0.151 | 1 | 0.702 |
DDR2 |
0.629 | -0.010 | 3 | 0.618 |
FLT1 |
0.628 | -0.096 | -1 | 0.460 |
LTK |
0.628 | -0.102 | 3 | 0.631 |
ALK |
0.628 | -0.117 | 3 | 0.609 |
EPHA3 |
0.627 | -0.100 | 2 | 0.625 |
FGFR3 |
0.627 | -0.089 | 3 | 0.653 |
FLT4 |
0.627 | -0.108 | 3 | 0.647 |
MET |
0.626 | -0.103 | 3 | 0.677 |
FRK |
0.626 | -0.108 | -1 | 0.482 |
BLK |
0.626 | -0.076 | -1 | 0.469 |
EPHA5 |
0.624 | -0.063 | 2 | 0.661 |
NTRK3 |
0.624 | -0.092 | -1 | 0.421 |
ERBB2 |
0.624 | -0.125 | 1 | 0.725 |
NTRK2 |
0.623 | -0.141 | 3 | 0.637 |
INSR |
0.623 | -0.102 | 3 | 0.629 |
LYN |
0.623 | -0.096 | 3 | 0.622 |
CSK |
0.622 | -0.085 | 2 | 0.639 |
FGFR4 |
0.622 | -0.049 | -1 | 0.451 |
EGFR |
0.622 | -0.056 | 1 | 0.670 |
EPHA8 |
0.621 | -0.086 | -1 | 0.456 |
PTK2B |
0.620 | -0.088 | -1 | 0.465 |
FYN |
0.620 | -0.082 | -1 | 0.443 |
MATK |
0.618 | -0.103 | -1 | 0.462 |
EPHA2 |
0.617 | -0.070 | -1 | 0.436 |
MUSK |
0.616 | -0.104 | 1 | 0.630 |
IGF1R |
0.610 | -0.098 | 3 | 0.569 |
SRC |
0.608 | -0.136 | -1 | 0.451 |
PTK2 |
0.608 | -0.084 | -1 | 0.412 |
SYK |
0.607 | -0.095 | -1 | 0.409 |
CK1G2 |
0.603 | -0.107 | -3 | 0.312 |
ERBB4 |
0.599 | -0.092 | 1 | 0.632 |
FES |
0.594 | -0.141 | -1 | 0.438 |
ZAP70 |
0.589 | -0.079 | -1 | 0.402 |