Motif 592 (n=94)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKT7 RGPD3 S1605 ochoa RanBP2-like and GRIP domain-containing protein 3 None
B2RTY4 MYO9A S1219 ochoa Unconventional myosin-IXa (Unconventional myosin-9a) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
K7ELQ4 ATF7-NPFF S73 ochoa ATF7-NPFF readthrough None
O14715 RGPD8 S1604 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15061 SYNM S913 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O43683 BUB1 S250 psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O75943 RAD17 S359 ochoa|psp Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}.
O94925 GLS S314 psp Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30239721, PubMed:30575854, PubMed:30970188). {ECO:0000269|PubMed:30239721, ECO:0000269|PubMed:30575854, ECO:0000269|PubMed:30970188}.; FUNCTION: [Isoform 2]: Lacks catalytic activity. {ECO:0000269|PubMed:11015561}.
O95197 RTN3 S650 ochoa Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}.
O95425 SVIL S1400 ochoa Supervillin (Archvillin) (p205/p250) [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
P01042 KNG1 S329 ochoa Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}.
P04406 GAPDH S148 ochoa|psp Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.
P06748 NPM1 S82 ochoa Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.
P08238 HSP90AB1 S490 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P0DJD0 RGPD1 S1589 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1597 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P16070 CD44 S718 ochoa CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.
P17302 GJA1 S306 ochoa Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
P18065 IGFBP2 S142 ochoa|psp Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). {ECO:0000269|PubMed:16569642, ECO:0000269|PubMed:18563800, ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:26076738, ECO:0000269|PubMed:38796567}.
P18583 SON S1783 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P28290 ITPRID2 S111 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P33981 TTK S345 psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35221 CTNNA1 S690 ochoa Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}.
P35222 CTNNB1 S675 ochoa|psp Catenin beta-1 (Beta-catenin) Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}.
P41236 PPP1R2 S122 ochoa|psp Protein phosphatase inhibitor 2 (IPP-2) Inhibitor of protein-phosphatase 1.
P49792 RANBP2 S2580 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50148 GNAQ S154 psp Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}.
P52630 STAT2 S393 psp Signal transducer and activator of transcription 2 (p113) Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}.
P52701 MSH6 S275 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P56645 PER3 S700 ochoa Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}.
P61081 UBE2M S50 ochoa NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.
P61978 HNRNPK S420 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P78527 PRKDC S1861 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q01543 FLI1 S76 ochoa Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}.
Q03014 HHEX S213 ochoa Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein) Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}.
Q08170 SRSF4 S113 ochoa Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}.
Q12912 IRAG2 S345 ochoa Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
Q13017 ARHGAP5 S951 ochoa Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}.
Q13243 SRSF5 S117 ochoa Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Q13247 SRSF6 S119 ochoa Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}.
Q13561 DCTN2 S203 ochoa Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.
Q14247 CTTN S156 ochoa Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14980 NUMA1 S1991 ochoa|psp Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15185 PTGES3 S34 ochoa Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
Q27J81 INF2 S1229 ochoa Inverted formin-2 (HBEBP2-binding protein C) Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.
Q3L8U1 CHD9 S612 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q4G0J3 LARP7 S299 ochoa La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.
Q5SW79 CEP170 S485 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T5P2 KIAA1217 S1245 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q641Q2 WASHC2A S909 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6NXS1 PPP1R2B S122 ochoa|psp Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.
Q6ZV73 FGD6 S692 ochoa FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q6ZWE6 PLEKHM3 S460 ochoa Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}.
Q7L2Z9 CENPQ S249 ochoa|psp Centromere protein Q (CENP-Q) Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}.
Q7Z3J3 RGPD4 S1605 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q8TDJ6 DMXL2 S1288 ochoa DmX-like protein 2 (Rabconnectin-3) May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
Q96EE3 SEH1L S260 ochoa Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900). {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.
Q96J84 KIRREL1 S574 ochoa Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}.
Q96JM7 L3MBTL3 S601 ochoa Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96NE9 FRMD6 S352 ochoa FERM domain-containing protein 6 (Willin) None
Q96SI9 STRBP S466 ochoa Spermatid perinuclear RNA-binding protein Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}.
Q99459 CDC5L S228 ochoa Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}.
Q99567 NUP88 S540 ochoa Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}.
Q99666 RGPD5 S1604 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99698 LYST S2167 ochoa Lysosomal-trafficking regulator (Beige homolog) Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.
Q99755 PIP5K1A S72 ochoa Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}.
Q9BZF1 OSBPL8 S808 ochoa Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.
Q9C0C2 TNKS1BP1 S836 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S963 ochoa 182 kDa tankyrase-1-binding protein None
Q9H0U4 RAB1B S179 ochoa Ras-related protein Rab-1B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}.
Q9H4L5 OSBPL3 S326 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9HCH5 SYTL2 S316 ochoa Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
Q9NQ84 GPRC5C S415 ochoa G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}.
Q9NQC3 RTN4 S441 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NSI6 BRWD1 S1605 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9NVU7 SDAD1 S459 ochoa Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}.
Q9NXD2 MTMR10 S622 ochoa Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) None
Q9P241 ATP10D S521 ochoa Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}.
Q9UHB6 LIMA1 S61 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9Y2W1 THRAP3 S207 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y371 SH3GLB1 S190 ochoa Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1) May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.
Q9Y4W2 LAS1L S235 ochoa Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}.
Q9Y5B6 PAXBP1 S155 ochoa PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}.
Q9Y623 MYH4 S647 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
P46060 RANGAP1 S454 Sugiyama Ran GTPase-activating protein 1 (RanGAP1) GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.
O75582 RPS6KA5 S647 Sugiyama Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
O94804 STK10 S824 Sugiyama Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
P51813 BMX S208 Sugiyama Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
P51955 NEK2 S241 GPS6|SIGNOR|EPSD|PSP Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.
O15226 NKRF S532 Sugiyama NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}.
Q16654 PDK4 S389 Sugiyama [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}.
Q5S007 LRRK2 S1345 EPSD|PSP Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}.
P20810 CAST S287 Sugiyama Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P00492 HPRT1 S92 Sugiyama Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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reactome_id name p -log10_p
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 4.678367e-08 7.330
R-HSA-177243 Interactions of Rev with host cellular proteins 1.258934e-06 5.900
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.095023e-06 5.679
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 4.157648e-06 5.381
R-HSA-180746 Nuclear import of Rev protein 1.247124e-05 4.904
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.942233e-05 4.712
R-HSA-1640170 Cell Cycle 1.562314e-05 4.806
R-HSA-68877 Mitotic Prometaphase 2.221677e-05 4.653
R-HSA-68886 M Phase 3.132143e-05 4.504
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 6.157882e-05 4.211
R-HSA-141424 Amplification of signal from the kinetochores 6.157882e-05 4.211
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.370037e-04 3.863
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.520448e-04 3.818
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.520448e-04 3.818
R-HSA-1855170 IPs transport between nucleus and cytosol 1.856561e-04 3.731
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.856561e-04 3.731
R-HSA-69618 Mitotic Spindle Checkpoint 1.515237e-04 3.820
R-HSA-69620 Cell Cycle Checkpoints 1.731127e-04 3.762
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.043311e-04 3.690
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.043311e-04 3.690
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.456861e-04 3.610
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.401628e-04 3.619
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.948834e-04 3.530
R-HSA-180910 Vpr-mediated nuclear import of PICs 2.927418e-04 3.534
R-HSA-69278 Cell Cycle, Mitotic 2.784710e-04 3.555
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.459377e-04 3.461
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.749772e-04 3.426
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.277434e-04 3.369
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.749772e-04 3.426
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.057194e-04 3.392
R-HSA-68875 Mitotic Prophase 4.114153e-04 3.386
R-HSA-3371556 Cellular response to heat stress 4.277434e-04 3.369
R-HSA-8953854 Metabolism of RNA 3.621072e-04 3.441
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.459377e-04 3.461
R-HSA-162909 Host Interactions of HIV factors 4.797818e-04 3.319
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 5.869593e-04 3.231
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6.291144e-04 3.201
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.028491e-03 2.988
R-HSA-70171 Glycolysis 1.226452e-03 2.911
R-HSA-2980766 Nuclear Envelope Breakdown 1.244485e-03 2.905
R-HSA-191859 snRNP Assembly 1.389784e-03 2.857
R-HSA-194441 Metabolism of non-coding RNA 1.389784e-03 2.857
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.531949e-03 2.815
R-HSA-8937144 Aryl hydrocarbon receptor signalling 1.531949e-03 2.815
R-HSA-168325 Viral Messenger RNA Synthesis 1.546530e-03 2.811
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.531949e-03 2.815
R-HSA-6784531 tRNA processing in the nucleus 1.629340e-03 2.788
R-HSA-2467813 Separation of Sister Chromatids 1.966677e-03 2.706
R-HSA-9705683 SARS-CoV-2-host interactions 2.016560e-03 2.695
R-HSA-70326 Glucose metabolism 2.512582e-03 2.600
R-HSA-5578749 Transcriptional regulation by small RNAs 2.633791e-03 2.579
R-HSA-1169408 ISG15 antiviral mechanism 3.002781e-03 2.522
R-HSA-9762292 Regulation of CDH11 function 3.953110e-03 2.403
R-HSA-162599 Late Phase of HIV Life Cycle 5.815853e-03 2.235
R-HSA-9675135 Diseases of DNA repair 6.874833e-03 2.163
R-HSA-68882 Mitotic Anaphase 6.891434e-03 2.162
R-HSA-2555396 Mitotic Metaphase and Anaphase 7.028810e-03 2.153
R-HSA-9610379 HCMV Late Events 8.379995e-03 2.077
R-HSA-913531 Interferon Signaling 8.242921e-03 2.084
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 7.814140e-03 2.107
R-HSA-162587 HIV Life Cycle 8.379995e-03 2.077
R-HSA-162906 HIV Infection 8.513916e-03 2.070
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 8.783487e-03 2.056
R-HSA-72187 mRNA 3'-end processing 9.147454e-03 2.039
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 9.943251e-03 2.002
R-HSA-211000 Gene Silencing by RNA 1.046222e-02 1.980
R-HSA-1483249 Inositol phosphate metabolism 1.200988e-02 1.920
R-HSA-73856 RNA Polymerase II Transcription Termination 1.329203e-02 1.876
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 1.405995e-02 1.852
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.489689e-02 1.827
R-HSA-9694516 SARS-CoV-2 Infection 1.631271e-02 1.787
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 1.711972e-02 1.767
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.711972e-02 1.767
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.714448e-02 1.766
R-HSA-72163 mRNA Splicing - Major Pathway 1.816477e-02 1.741
R-HSA-72172 mRNA Splicing 2.199963e-02 1.658
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.195617e-02 1.658
R-HSA-525793 Myogenesis 2.195617e-02 1.658
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 2.101627e-02 1.677
R-HSA-190827 Transport of connexins along the secretory pathway 2.101627e-02 1.677
R-HSA-190704 Oligomerization of connexins into connexons 2.101627e-02 1.677
R-HSA-1266695 Interleukin-7 signaling 2.069948e-02 1.684
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.195617e-02 1.658
R-HSA-9679506 SARS-CoV Infections 2.151923e-02 1.667
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.590966e-02 1.587
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.590966e-02 1.587
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 2.590966e-02 1.587
R-HSA-9759475 Regulation of CDH11 Expression and Function 2.590966e-02 1.587
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 3.012809e-02 1.521
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.012809e-02 1.521
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 3.159092e-02 1.500
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 3.159092e-02 1.500
R-HSA-176187 Activation of ATR in response to replication stress 3.159092e-02 1.500
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 3.207282e-02 1.494
R-HSA-9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage 3.478328e-02 1.459
R-HSA-3371511 HSF1 activation 3.771338e-02 1.424
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 3.478328e-02 1.459
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 3.459882e-02 1.461
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 3.614299e-02 1.442
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.509279e-02 1.455
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 3.459882e-02 1.461
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 4.093106e-02 1.388
R-HSA-191650 Regulation of gap junction activity 4.159465e-02 1.381
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 4.159465e-02 1.381
R-HSA-5619102 SLC transporter disorders 4.308166e-02 1.366
R-HSA-9609646 HCMV Infection 4.356620e-02 1.361
R-HSA-3371568 Attenuation phase 4.424842e-02 1.354
R-HSA-5218920 VEGFR2 mediated vascular permeability 4.594341e-02 1.338
R-HSA-72306 tRNA processing 4.595452e-02 1.338
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 6.174419e-02 1.209
R-HSA-774815 Nucleosome assembly 5.476500e-02 1.261
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 5.476500e-02 1.261
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 4.835837e-02 1.316
R-HSA-8857538 PTK6 promotes HIF1A stabilization 6.174419e-02 1.209
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 4.940394e-02 1.306
R-HSA-199920 CREB phosphorylation 6.174419e-02 1.209
R-HSA-9861718 Regulation of pyruvate metabolism 5.659583e-02 1.247
R-HSA-9855142 Cellular responses to mechanical stimuli 6.083587e-02 1.216
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 5.476500e-02 1.261
R-HSA-168255 Influenza Infection 5.280140e-02 1.277
R-HSA-1483255 PI Metabolism 4.681035e-02 1.330
R-HSA-75153 Apoptotic execution phase 5.659583e-02 1.247
R-HSA-9766229 Degradation of CDH1 6.221429e-02 1.206
R-HSA-3371571 HSF1-dependent transactivation 6.606111e-02 1.180
R-HSA-9609690 HCMV Early Events 6.716644e-02 1.173
R-HSA-8951430 RUNX3 regulates WNT signaling 6.836694e-02 1.165
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 6.836694e-02 1.165
R-HSA-5336415 Uptake and function of diphtheria toxin 6.836694e-02 1.165
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 6.836694e-02 1.165
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 6.998541e-02 1.155
R-HSA-196025 Formation of annular gap junctions 7.494335e-02 1.125
R-HSA-190873 Gap junction degradation 8.147374e-02 1.089
R-HSA-9700645 ALK mutants bind TKIs 8.147374e-02 1.089
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 9.439774e-02 1.025
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.007920e-01 0.997
R-HSA-5339716 Signaling by GSK3beta mutants 1.007920e-01 0.997
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.071415e-01 0.970
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-196299 Beta-catenin phosphorylation cascade 1.259245e-01 0.900
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.382284e-01 0.859
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.443158e-01 0.841
R-HSA-202040 G-protein activation 1.682421e-01 0.774
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 9.067004e-02 1.043
R-HSA-380259 Loss of Nlp from mitotic centrosomes 9.067004e-02 1.043
R-HSA-8854518 AURKA Activation by TPX2 9.718806e-02 1.012
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.128841e-01 0.947
R-HSA-380287 Centrosome maturation 1.174833e-01 0.930
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.557823e-01 0.807
R-HSA-373753 Nephrin family interactions 1.623234e-01 0.790
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.134465e-01 0.945
R-HSA-6807878 COPI-mediated anterograde transport 1.757291e-01 0.755
R-HSA-912694 Regulation of IFNA/IFNB signaling 1.799553e-01 0.745
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1.071415e-01 0.970
R-HSA-73863 RNA Polymerase I Transcription Termination 2.085280e-01 0.681
R-HSA-204005 COPII-mediated vesicle transport 1.060779e-01 0.974
R-HSA-9754189 Germ layer formation at gastrulation 1.563630e-01 0.806
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1.443158e-01 0.841
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 1.320980e-01 0.879
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.382284e-01 0.859
R-HSA-190872 Transport of connexons to the plasma membrane 1.503606e-01 0.823
R-HSA-9613829 Chaperone Mediated Autophagy 1.503606e-01 0.823
R-HSA-199977 ER to Golgi Anterograde Transport 1.127573e-01 0.948
R-HSA-399997 Acetylcholine regulates insulin secretion 1.382284e-01 0.859
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 1.915051e-01 0.718
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 7.398429e-02 1.131
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 1.757291e-01 0.755
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.063276e-01 0.685
R-HSA-193634 Axonal growth inhibition (RHOA activation) 7.494335e-02 1.125
R-HSA-400451 Free fatty acids regulate insulin secretion 1.857505e-01 0.731
R-HSA-9764561 Regulation of CDH1 Function 7.805493e-02 1.108
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.106027e-01 0.956
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 7.601082e-02 1.119
R-HSA-9700206 Signaling by ALK in cancer 2.063276e-01 0.685
R-HSA-5358508 Mismatch Repair 1.503606e-01 0.823
R-HSA-8876384 Listeria monocytogenes entry into host cells 1.741193e-01 0.759
R-HSA-948021 Transport to the Golgi and subsequent modification 2.067449e-01 0.685
R-HSA-193697 p75NTR regulates axonogenesis 8.147374e-02 1.089
R-HSA-428930 Thromboxane signalling through TP receptor 1.915051e-01 0.718
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 1.563630e-01 0.806
R-HSA-9734207 Nucleotide salvage defects 7.494335e-02 1.125
R-HSA-399954 Sema3A PAK dependent Axon repulsion 1.259245e-01 0.900
R-HSA-9834899 Specification of the neural plate border 1.563630e-01 0.806
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 1.291810e-01 0.889
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.387271e-01 0.858
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.089052e-01 0.680
R-HSA-9734767 Developmental Cell Lineages 1.418959e-01 0.848
R-HSA-198753 ERK/MAPK targets 1.682421e-01 0.774
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.085280e-01 0.681
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 8.795843e-02 1.056
R-HSA-9796292 Formation of axial mesoderm 1.134465e-01 0.945
R-HSA-429947 Deadenylation of mRNA 1.915051e-01 0.718
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.196787e-01 0.658
R-HSA-5693607 Processing of DNA double-strand break ends 1.315527e-01 0.881
R-HSA-453276 Regulation of mitotic cell cycle 1.083339e-01 0.965
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 1.083339e-01 0.965
R-HSA-844456 The NLRP3 inflammasome 1.563630e-01 0.806
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 1.682421e-01 0.774
R-HSA-9909396 Circadian clock 8.844204e-02 1.053
R-HSA-9834752 Respiratory syncytial virus genome replication 8.147374e-02 1.089
R-HSA-9735804 Diseases of nucleotide metabolism 1.134465e-01 0.945
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.259245e-01 0.900
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.291810e-01 0.889
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 8.852746e-02 1.053
R-HSA-2160916 Hyaluronan degradation 1.972193e-01 0.705
R-HSA-5693532 DNA Double-Strand Break Repair 1.218904e-01 0.914
R-HSA-9823730 Formation of definitive endoderm 1.623234e-01 0.790
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 1.741193e-01 0.759
R-HSA-69275 G2/M Transition 1.781526e-01 0.749
R-HSA-453274 Mitotic G2-G2/M phases 1.816645e-01 0.741
R-HSA-622312 Inflammasomes 2.141230e-01 0.669
R-HSA-9860931 Response of endothelial cells to shear stress 1.960547e-01 0.708
R-HSA-8849932 Synaptic adhesion-like molecules 1.503606e-01 0.823
R-HSA-1482801 Acyl chain remodelling of PS 1.972193e-01 0.705
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 2.028935e-01 0.693
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 1.060779e-01 0.974
R-HSA-9830364 Formation of the nephric duct 1.972193e-01 0.705
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 7.494335e-02 1.125
R-HSA-8863678 Neurodegenerative Diseases 1.915051e-01 0.718
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.915051e-01 0.718
R-HSA-5621575 CD209 (DC-SIGN) signaling 1.915051e-01 0.718
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.085280e-01 0.681
R-HSA-69473 G2/M DNA damage checkpoint 1.151777e-01 0.939
R-HSA-9679191 Potential therapeutics for SARS 1.172900e-01 0.931
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 1.972193e-01 0.705
R-HSA-8953897 Cellular responses to stimuli 1.229489e-01 0.910
R-HSA-70268 Pyruvate metabolism 1.484223e-01 0.829
R-HSA-8854691 Interleukin-20 family signaling 1.857505e-01 0.731
R-HSA-1834941 STING mediated induction of host immune responses 1.563630e-01 0.806
R-HSA-1280215 Cytokine Signaling in Immune system 8.737010e-02 1.059
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 7.805493e-02 1.108
R-HSA-5362517 Signaling by Retinoic Acid 8.428940e-02 1.074
R-HSA-9824446 Viral Infection Pathways 1.897070e-01 0.722
R-HSA-5685942 HDR through Homologous Recombination (HRR) 9.938980e-02 1.003
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.459854e-01 0.836
R-HSA-1483257 Phospholipid metabolism 1.850557e-01 0.733
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 1.226012e-01 0.912
R-HSA-5619115 Disorders of transmembrane transporters 1.220409e-01 0.913
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.244370e-01 0.649
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 2.251956e-01 0.647
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2.251956e-01 0.647
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 2.270350e-01 0.644
R-HSA-5694530 Cargo concentration in the ER 2.306738e-01 0.637
R-HSA-9833109 Evasion by RSV of host interferon responses 2.306738e-01 0.637
R-HSA-4420097 VEGFA-VEGFR2 Pathway 2.322376e-01 0.634
R-HSA-4791275 Signaling by WNT in cancer 2.361135e-01 0.627
R-HSA-5693538 Homology Directed Repair 2.400556e-01 0.620
R-HSA-9733709 Cardiogenesis 2.415152e-01 0.617
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 2.468790e-01 0.608
R-HSA-8964539 Glutamate and glutamine metabolism 2.468790e-01 0.608
R-HSA-73886 Chromosome Maintenance 2.478869e-01 0.606
R-HSA-190861 Gap junction assembly 2.522052e-01 0.598
R-HSA-392518 Signal amplification 2.522052e-01 0.598
R-HSA-2142845 Hyaluronan metabolism 2.522052e-01 0.598
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2.522052e-01 0.598
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 2.522052e-01 0.598
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 2.574940e-01 0.589
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 2.609576e-01 0.583
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 2.609576e-01 0.583
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 2.609576e-01 0.583
R-HSA-194138 Signaling by VEGF 2.609576e-01 0.583
R-HSA-3700989 Transcriptional Regulation by TP53 2.617567e-01 0.582
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 2.627458e-01 0.580
R-HSA-69481 G2/M Checkpoints 2.661892e-01 0.575
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.679607e-01 0.572
R-HSA-74217 Purine salvage 2.731391e-01 0.564
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 2.731391e-01 0.564
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 2.782812e-01 0.556
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 2.782812e-01 0.556
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 2.782812e-01 0.556
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 2.782812e-01 0.556
R-HSA-9843745 Adipogenesis 2.792670e-01 0.554
R-HSA-8856688 Golgi-to-ER retrograde transport 2.818814e-01 0.550
R-HSA-1474228 Degradation of the extracellular matrix 2.818814e-01 0.550
R-HSA-73894 DNA Repair 2.829132e-01 0.548
R-HSA-9006931 Signaling by Nuclear Receptors 2.876440e-01 0.541
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.884574e-01 0.540
R-HSA-8853884 Transcriptional Regulation by VENTX 2.884574e-01 0.540
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 2.884574e-01 0.540
R-HSA-9932298 Degradation of CRY and PER proteins 2.934920e-01 0.532
R-HSA-9018519 Estrogen-dependent gene expression 2.949406e-01 0.530
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 2.975491e-01 0.526
R-HSA-73762 RNA Polymerase I Transcription Initiation 2.984913e-01 0.525
R-HSA-400508 Incretin synthesis, secretion, and inactivation 2.984913e-01 0.525
R-HSA-597592 Post-translational protein modification 3.006095e-01 0.522
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 3.034556e-01 0.518
R-HSA-190828 Gap junction trafficking 3.083850e-01 0.511
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.083850e-01 0.511
R-HSA-9824272 Somitogenesis 3.132798e-01 0.504
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 3.132798e-01 0.504
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 3.132798e-01 0.504
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 3.132798e-01 0.504
R-HSA-2262752 Cellular responses to stress 3.152757e-01 0.501
R-HSA-162582 Signal Transduction 3.166536e-01 0.499
R-HSA-72165 mRNA Splicing - Minor Pathway 3.181404e-01 0.497
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 3.181404e-01 0.497
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 3.181404e-01 0.497
R-HSA-437239 Recycling pathway of L1 3.229668e-01 0.491
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.277593e-01 0.484
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 3.277593e-01 0.484
R-HSA-70263 Gluconeogenesis 3.277593e-01 0.484
R-HSA-157858 Gap junction trafficking and regulation 3.325182e-01 0.478
R-HSA-74160 Gene expression (Transcription) 3.330443e-01 0.477
R-HSA-9856651 MITF-M-dependent gene expression 3.338753e-01 0.476
R-HSA-9748787 Azathioprine ADME 3.372437e-01 0.472
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 3.372437e-01 0.472
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 3.390265e-01 0.470
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 3.441658e-01 0.463
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.465955e-01 0.460
R-HSA-73772 RNA Polymerase I Promoter Escape 3.465955e-01 0.460
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.465955e-01 0.460
R-HSA-5339562 Uptake and actions of bacterial toxins 3.465955e-01 0.460
R-HSA-1989781 PPARA activates gene expression 3.467308e-01 0.460
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.512222e-01 0.454
R-HSA-9639288 Amino acids regulate mTORC1 3.512222e-01 0.454
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 3.518512e-01 0.454
R-HSA-877300 Interferon gamma signaling 3.569580e-01 0.447
R-HSA-5633007 Regulation of TP53 Activity 3.595062e-01 0.444
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.603784e-01 0.443
R-HSA-109581 Apoptosis 3.645917e-01 0.438
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 3.738731e-01 0.427
R-HSA-429914 Deadenylation-dependent mRNA decay 3.783084e-01 0.422
R-HSA-8873719 RAB geranylgeranylation 3.827124e-01 0.417
R-HSA-9793380 Formation of paraxial mesoderm 3.870856e-01 0.412
R-HSA-450294 MAP kinase activation 3.870856e-01 0.412
R-HSA-112043 PLC beta mediated events 3.870856e-01 0.412
R-HSA-8956321 Nucleotide salvage 3.870856e-01 0.412
R-HSA-5621481 C-type lectin receptors (CLRs) 3.897826e-01 0.409
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.914280e-01 0.407
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.914280e-01 0.407
R-HSA-375165 NCAM signaling for neurite out-growth 3.914280e-01 0.407
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.914280e-01 0.407
R-HSA-9707616 Heme signaling 3.914280e-01 0.407
R-HSA-9909648 Regulation of PD-L1(CD274) expression 3.922784e-01 0.406
R-HSA-9764265 Regulation of CDH1 Expression and Function 3.947697e-01 0.404
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 3.947697e-01 0.404
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 3.957399e-01 0.403
R-HSA-8848021 Signaling by PTK6 3.957399e-01 0.403
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 3.957399e-01 0.403
R-HSA-69615 G1/S DNA Damage Checkpoints 3.957399e-01 0.403
R-HSA-373755 Semaphorin interactions 3.957399e-01 0.403
R-HSA-936837 Ion transport by P-type ATPases 4.000216e-01 0.398
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.000216e-01 0.398
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.084949e-01 0.389
R-HSA-112040 G-protein mediated events 4.126869e-01 0.384
R-HSA-9830369 Kidney development 4.126869e-01 0.384
R-HSA-195253 Degradation of beta-catenin by the destruction complex 4.250872e-01 0.372
R-HSA-448424 Interleukin-17 signaling 4.250872e-01 0.372
R-HSA-1500931 Cell-Cell communication 4.257567e-01 0.371
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.291627e-01 0.367
R-HSA-427413 NoRC negatively regulates rRNA expression 4.291627e-01 0.367
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 4.291627e-01 0.367
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.332095e-01 0.363
R-HSA-1852241 Organelle biogenesis and maintenance 4.332507e-01 0.363
R-HSA-5617833 Cilium Assembly 4.363787e-01 0.360
R-HSA-4086398 Ca2+ pathway 4.372279e-01 0.359
R-HSA-212165 Epigenetic regulation of gene expression 4.388486e-01 0.358
R-HSA-6798695 Neutrophil degranulation 4.393955e-01 0.357
R-HSA-8852135 Protein ubiquitination 4.451802e-01 0.351
R-HSA-73854 RNA Polymerase I Promoter Clearance 4.491145e-01 0.348
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 4.507013e-01 0.346
R-HSA-73864 RNA Polymerase I Transcription 4.569002e-01 0.340
R-HSA-216083 Integrin cell surface interactions 4.569002e-01 0.340
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 4.601366e-01 0.337
R-HSA-389948 Co-inhibition by PD-1 4.601366e-01 0.337
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 4.607521e-01 0.337
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 4.645769e-01 0.333
R-HSA-9833482 PKR-mediated signaling 4.645769e-01 0.333
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 4.683748e-01 0.329
R-HSA-5357801 Programmed Cell Death 4.741138e-01 0.324
R-HSA-9707564 Cytoprotection by HMOX1 4.758907e-01 0.322
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 4.758907e-01 0.322
R-HSA-6794362 Protein-protein interactions at synapses 4.833012e-01 0.316
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.869674e-01 0.313
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.869674e-01 0.313
R-HSA-9730414 MITF-M-regulated melanocyte development 4.924114e-01 0.308
R-HSA-390466 Chaperonin-mediated protein folding 4.942227e-01 0.306
R-HSA-9645723 Diseases of programmed cell death 4.978121e-01 0.303
R-HSA-418990 Adherens junctions interactions 5.036450e-01 0.298
R-HSA-112310 Neurotransmitter release cycle 5.049153e-01 0.297
R-HSA-8951664 Neddylation 5.103088e-01 0.292
R-HSA-199991 Membrane Trafficking 5.149301e-01 0.288
R-HSA-391251 Protein folding 5.153839e-01 0.288
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.256329e-01 0.279
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.323460e-01 0.274
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.323460e-01 0.274
R-HSA-1266738 Developmental Biology 5.348881e-01 0.272
R-HSA-8878159 Transcriptional regulation by RUNX3 5.356671e-01 0.271
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.356671e-01 0.271
R-HSA-8957275 Post-translational protein phosphorylation 5.389648e-01 0.268
R-HSA-422356 Regulation of insulin secretion 5.389648e-01 0.268
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.389648e-01 0.268
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.389648e-01 0.268
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.389648e-01 0.268
R-HSA-193704 p75 NTR receptor-mediated signalling 5.422394e-01 0.266
R-HSA-192105 Synthesis of bile acids and bile salts 5.422394e-01 0.266
R-HSA-8939211 ESR-mediated signaling 5.448587e-01 0.264
R-HSA-111885 Opioid Signalling 5.582694e-01 0.253
R-HSA-5663205 Infectious disease 5.592447e-01 0.252
R-HSA-392499 Metabolism of proteins 5.611877e-01 0.251
R-HSA-9833110 RSV-host interactions 5.614080e-01 0.251
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 5.645244e-01 0.248
R-HSA-9692914 SARS-CoV-1-host interactions 5.676190e-01 0.246
R-HSA-421270 Cell-cell junction organization 5.736881e-01 0.241
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.737428e-01 0.241
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.767724e-01 0.239
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 5.797806e-01 0.237
R-HSA-166166 MyD88-independent TLR4 cascade 5.797806e-01 0.237
R-HSA-194068 Bile acid and bile salt metabolism 5.797806e-01 0.237
R-HSA-388841 Regulation of T cell activation by CD28 family 5.836619e-01 0.234
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.886788e-01 0.230
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 5.973901e-01 0.224
R-HSA-5628897 TP53 Regulates Metabolic Genes 5.973901e-01 0.224
R-HSA-416476 G alpha (q) signalling events 5.992648e-01 0.222
R-HSA-909733 Interferon alpha/beta signaling 6.002531e-01 0.222
R-HSA-373760 L1CAM interactions 6.030958e-01 0.220
R-HSA-9007101 Rab regulation of trafficking 6.059186e-01 0.218
R-HSA-1592230 Mitochondrial biogenesis 6.059186e-01 0.218
R-HSA-2980736 Peptide hormone metabolism 6.059186e-01 0.218
R-HSA-446203 Asparagine N-linked glycosylation 6.100076e-01 0.215
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.115045e-01 0.214
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.115045e-01 0.214
R-HSA-168256 Immune System 6.140914e-01 0.212
R-HSA-76002 Platelet activation, signaling and aggregation 6.181526e-01 0.209
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.197365e-01 0.208
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.197365e-01 0.208
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.224419e-01 0.206
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.224419e-01 0.206
R-HSA-2132295 MHC class II antigen presentation 6.224419e-01 0.206
R-HSA-446728 Cell junction organization 6.255164e-01 0.204
R-HSA-211945 Phase I - Functionalization of compounds 6.255164e-01 0.204
R-HSA-114608 Platelet degranulation 6.356853e-01 0.197
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.382782e-01 0.195
R-HSA-199418 Negative regulation of the PI3K/AKT network 6.434092e-01 0.192
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.534558e-01 0.185
R-HSA-163685 Integration of energy metabolism 6.632218e-01 0.178
R-HSA-3858494 Beta-catenin independent WNT signaling 6.632218e-01 0.178
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 6.750464e-01 0.171
R-HSA-449147 Signaling by Interleukins 6.752255e-01 0.171
R-HSA-8856828 Clathrin-mediated endocytosis 6.819427e-01 0.166
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.931155e-01 0.159
R-HSA-166520 Signaling by NTRKs 6.931155e-01 0.159
R-HSA-9758941 Gastrulation 6.953030e-01 0.158
R-HSA-2142753 Arachidonate metabolism 7.017730e-01 0.154
R-HSA-8957322 Metabolism of steroids 7.024713e-01 0.153
R-HSA-5653656 Vesicle-mediated transport 7.039084e-01 0.152
R-HSA-73887 Death Receptor Signaling 7.060104e-01 0.151
R-HSA-9612973 Autophagy 7.101882e-01 0.149
R-HSA-1474244 Extracellular matrix organization 7.129685e-01 0.147
R-HSA-9711097 Cellular response to starvation 7.143072e-01 0.146
R-HSA-9006936 Signaling by TGFB family members 7.183681e-01 0.144
R-HSA-1428517 Aerobic respiration and respiratory electron transport 7.274307e-01 0.138
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 7.351357e-01 0.134
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.397013e-01 0.131
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.470550e-01 0.127
R-HSA-168249 Innate Immune System 7.486692e-01 0.126
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 7.488610e-01 0.126
R-HSA-9678108 SARS-CoV-1 Infection 7.488610e-01 0.126
R-HSA-201681 TCF dependent signaling in response to WNT 7.628564e-01 0.118
R-HSA-375276 Peptide ligand-binding receptors 7.679029e-01 0.115
R-HSA-8868773 rRNA processing in the nucleus and cytosol 7.712079e-01 0.113
R-HSA-983712 Ion channel transport 7.728429e-01 0.112
R-HSA-168898 Toll-like Receptor Cascades 7.760782e-01 0.110
R-HSA-1630316 Glycosaminoglycan metabolism 7.792679e-01 0.108
R-HSA-9824439 Bacterial Infection Pathways 7.908427e-01 0.102
R-HSA-1483206 Glycerophospholipid biosynthesis 7.945529e-01 0.100
R-HSA-418594 G alpha (i) signalling events 8.092713e-01 0.092
R-HSA-9748784 Drug ADME 8.168553e-01 0.088
R-HSA-1643685 Disease 8.171225e-01 0.088
R-HSA-109582 Hemostasis 8.269401e-01 0.083
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.307263e-01 0.081
R-HSA-72312 rRNA processing 8.343904e-01 0.079
R-HSA-3247509 Chromatin modifying enzymes 8.367556e-01 0.077
R-HSA-15869 Metabolism of nucleotides 8.390873e-01 0.076
R-HSA-202733 Cell surface interactions at the vascular wall 8.402408e-01 0.076
R-HSA-556833 Metabolism of lipids 8.480438e-01 0.072
R-HSA-4839726 Chromatin organization 8.534592e-01 0.069
R-HSA-112316 Neuronal System 8.641116e-01 0.063
R-HSA-73857 RNA Polymerase II Transcription 8.683046e-01 0.061
R-HSA-9711123 Cellular response to chemical stress 8.722050e-01 0.059
R-HSA-9658195 Leishmania infection 8.836410e-01 0.054
R-HSA-9824443 Parasitic Infection Pathways 8.836410e-01 0.054
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.844774e-01 0.053
R-HSA-1257604 PIP3 activates AKT signaling 8.948239e-01 0.048
R-HSA-195721 Signaling by WNT 8.970779e-01 0.047
R-HSA-211859 Biological oxidations 9.008535e-01 0.045
R-HSA-422475 Axon guidance 9.127960e-01 0.040
R-HSA-112315 Transmission across Chemical Synapses 9.140919e-01 0.039
R-HSA-9006925 Intracellular signaling by second messengers 9.251296e-01 0.034
R-HSA-9675108 Nervous system development 9.299132e-01 0.032
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.447881e-01 0.025
R-HSA-1430728 Metabolism 9.470470e-01 0.024
R-HSA-1280218 Adaptive Immune System 9.485876e-01 0.023
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.490282e-01 0.023
R-HSA-8978868 Fatty acid metabolism 9.536248e-01 0.021
R-HSA-5668914 Diseases of metabolism 9.599063e-01 0.018
R-HSA-212436 Generic Transcription Pathway 9.715446e-01 0.013
R-HSA-388396 GPCR downstream signalling 9.784492e-01 0.009
R-HSA-372790 Signaling by GPCR 9.873091e-01 0.006
R-HSA-500792 GPCR ligand binding 9.877517e-01 0.005
R-HSA-71291 Metabolism of amino acids and derivatives 9.901073e-01 0.004
R-HSA-382551 Transport of small molecules 9.993404e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
FAM20CFAM20C 0.819 0.452 2 0.829
COTCOT 0.816 0.199 2 0.727
CAMK2GCAMK2G 0.800 0.135 2 0.679
CLK3CLK3 0.799 0.147 1 0.748
CAMK2BCAMK2B 0.798 0.199 2 0.732
MOSMOS 0.798 0.135 1 0.813
PIM3PIM3 0.797 0.065 -3 0.758
NDR2NDR2 0.796 0.030 -3 0.789
PRPKPRPK 0.795 0.017 -1 0.760
CDC7CDC7 0.795 -0.012 1 0.763
DSTYKDSTYK 0.794 0.076 2 0.739
IKKBIKKB 0.793 0.003 -2 0.678
PIM1PIM1 0.792 0.102 -3 0.713
PRKD2PRKD2 0.790 0.046 -3 0.707
GRK1GRK1 0.790 0.117 -2 0.690
CAMK1BCAMK1B 0.790 0.021 -3 0.803
GCN2GCN2 0.789 -0.070 2 0.599
RSK2RSK2 0.789 0.051 -3 0.692
BMPR2BMPR2 0.789 0.081 -2 0.841
NDR1NDR1 0.788 0.033 -3 0.786
TGFBR2TGFBR2 0.788 0.103 -2 0.870
PDHK4PDHK4 0.787 -0.095 1 0.781
LATS2LATS2 0.787 0.035 -5 0.730
IKKAIKKA 0.787 0.049 -2 0.681
PRKD1PRKD1 0.787 0.000 -3 0.745
TBK1TBK1 0.787 -0.056 1 0.674
BMPR1BBMPR1B 0.786 0.198 1 0.691
RAF1RAF1 0.786 -0.077 1 0.770
ATMATM 0.786 0.078 1 0.719
ALK2ALK2 0.785 0.269 -2 0.865
TGFBR1TGFBR1 0.785 0.229 -2 0.866
RIPK3RIPK3 0.785 -0.010 3 0.681
ATRATR 0.785 -0.000 1 0.778
GRK6GRK6 0.785 0.063 1 0.748
PKN3PKN3 0.785 0.022 -3 0.756
NEK6NEK6 0.784 -0.036 -2 0.861
SKMLCKSKMLCK 0.784 0.050 -2 0.761
IKKEIKKE 0.784 -0.071 1 0.658
PLK1PLK1 0.784 0.112 -2 0.834
P70S6KBP70S6KB 0.784 0.037 -3 0.732
CAMK2DCAMK2D 0.783 0.044 -3 0.776
PLK3PLK3 0.782 0.112 2 0.632
MAPKAPK2MAPKAPK2 0.782 0.043 -3 0.660
ALK4ALK4 0.781 0.190 -2 0.870
CAMK2ACAMK2A 0.781 0.083 2 0.675
NEK7NEK7 0.781 -0.088 -3 0.806
MTORMTOR 0.781 -0.124 1 0.703
AURCAURC 0.781 0.060 -2 0.597
WNK1WNK1 0.781 0.004 -2 0.743
CAMLCKCAMLCK 0.780 0.014 -2 0.761
P90RSKP90RSK 0.780 -0.005 -3 0.681
PKACGPKACG 0.780 0.022 -2 0.649
ULK2ULK2 0.779 -0.163 2 0.604
NIKNIK 0.779 -0.033 -3 0.839
RSK4RSK4 0.778 0.061 -3 0.664
PDHK1PDHK1 0.778 -0.182 1 0.771
MST4MST4 0.778 -0.014 2 0.676
NUAK2NUAK2 0.778 -0.024 -3 0.773
ACVR2BACVR2B 0.778 0.182 -2 0.855
ACVR2AACVR2A 0.778 0.168 -2 0.857
GRK4GRK4 0.777 -0.030 -2 0.775
GRK5GRK5 0.777 -0.097 -3 0.818
SRPK1SRPK1 0.777 -0.001 -3 0.651
PRKXPRKX 0.776 0.091 -3 0.621
BMPR1ABMPR1A 0.776 0.205 1 0.676
LATS1LATS1 0.776 0.122 -3 0.796
TSSK2TSSK2 0.776 0.007 -5 0.789
NLKNLK 0.776 -0.094 1 0.739
MLK1MLK1 0.776 -0.104 2 0.630
HUNKHUNK 0.776 -0.092 2 0.600
RSK3RSK3 0.776 -0.015 -3 0.676
MAPKAPK3MAPKAPK3 0.775 -0.024 -3 0.704
BCKDKBCKDK 0.775 -0.115 -1 0.673
PKACBPKACB 0.775 0.060 -2 0.612
DAPK2DAPK2 0.774 -0.036 -3 0.801
MARK4MARK4 0.774 -0.038 4 0.820
PKN2PKN2 0.774 -0.034 -3 0.795
CDKL1CDKL1 0.774 -0.062 -3 0.709
AMPKA1AMPKA1 0.774 -0.029 -3 0.796
DNAPKDNAPK 0.773 0.078 1 0.658
PKCDPKCD 0.773 -0.017 2 0.606
PAK1PAK1 0.773 0.014 -2 0.670
TSSK1TSSK1 0.773 -0.005 -3 0.806
ERK5ERK5 0.773 -0.083 1 0.697
AURBAURB 0.772 0.041 -2 0.596
ANKRD3ANKRD3 0.772 -0.064 1 0.815
MSK1MSK1 0.772 0.026 -3 0.652
CAMK4CAMK4 0.772 -0.026 -3 0.784
SMG1SMG1 0.772 0.015 1 0.740
CK2A2CK2A2 0.771 0.158 1 0.659
MASTLMASTL 0.771 -0.171 -2 0.721
GRK7GRK7 0.771 0.075 1 0.670
MYLK4MYLK4 0.771 0.026 -2 0.682
CHAK2CHAK2 0.771 -0.090 -1 0.748
ULK1ULK1 0.771 -0.170 -3 0.786
TLK2TLK2 0.770 0.035 1 0.741
KISKIS 0.770 -0.026 1 0.596
WNK3WNK3 0.770 -0.163 1 0.773
MSK2MSK2 0.770 -0.027 -3 0.646
CLK2CLK2 0.770 0.084 -3 0.672
NEK9NEK9 0.770 -0.161 2 0.641
SRPK2SRPK2 0.770 -0.006 -3 0.578
RIPK1RIPK1 0.769 -0.108 1 0.805
PKRPKR 0.769 0.010 1 0.829
AMPKA2AMPKA2 0.769 -0.029 -3 0.768
DLKDLK 0.769 -0.098 1 0.750
PRKD3PRKD3 0.768 -0.027 -3 0.679
CLK4CLK4 0.767 0.021 -3 0.699
TTBK2TTBK2 0.767 -0.141 2 0.508
PAK3PAK3 0.766 -0.040 -2 0.668
CAMK1GCAMK1G 0.766 -0.005 -3 0.702
NUAK1NUAK1 0.765 -0.048 -3 0.743
MNK2MNK2 0.765 -0.016 -2 0.706
PAK6PAK6 0.765 0.026 -2 0.610
BRSK1BRSK1 0.765 -0.032 -3 0.733
PIM2PIM2 0.765 0.042 -3 0.670
SRPK3SRPK3 0.765 -0.027 -3 0.630
MELKMELK 0.765 -0.044 -3 0.755
HIPK4HIPK4 0.764 -0.091 1 0.732
MLK2MLK2 0.764 -0.152 2 0.649
CK2A1CK2A1 0.764 0.147 1 0.636
PAK2PAK2 0.763 -0.028 -2 0.660
GRK2GRK2 0.763 -0.001 -2 0.695
CDKL5CDKL5 0.763 -0.086 -3 0.691
NIM1NIM1 0.763 -0.124 3 0.700
AURAAURA 0.763 0.019 -2 0.590
CLK1CLK1 0.762 0.011 -3 0.691
MLK3MLK3 0.762 -0.088 2 0.564
PKG2PKG2 0.762 0.004 -2 0.594
PLK2PLK2 0.762 0.089 -3 0.747
CHK1CHK1 0.762 -0.001 -3 0.761
MNK1MNK1 0.761 -0.004 -2 0.711
DCAMKL1DCAMKL1 0.761 0.022 -3 0.737
IRE1IRE1 0.761 -0.128 1 0.797
ICKICK 0.761 -0.096 -3 0.750
TLK1TLK1 0.760 -0.002 -2 0.858
PKACAPKACA 0.760 0.032 -2 0.567
PHKG1PHKG1 0.760 -0.063 -3 0.778
HRIHRI 0.760 -0.050 -2 0.839
MEK1MEK1 0.760 -0.114 2 0.657
PKCBPKCB 0.760 -0.060 2 0.563
PKCGPKCG 0.760 -0.067 2 0.545
MLK4MLK4 0.759 -0.079 2 0.551
SGK3SGK3 0.759 -0.007 -3 0.689
PLK4PLK4 0.759 -0.063 2 0.467
BRSK2BRSK2 0.759 -0.069 -3 0.771
PASKPASK 0.759 0.060 -3 0.771
DRAK1DRAK1 0.759 -0.039 1 0.718
IRE2IRE2 0.759 -0.087 2 0.551
PERKPERK 0.758 -0.042 -2 0.823
YSK4YSK4 0.758 -0.113 1 0.695
PKCAPKCA 0.758 -0.069 2 0.549
CAMK1DCAMK1D 0.758 0.021 -3 0.628
QIKQIK 0.758 -0.116 -3 0.778
PKCHPKCH 0.758 -0.072 2 0.537
CDK8CDK8 0.757 -0.078 1 0.562
QSKQSK 0.757 -0.075 4 0.791
SIKSIK 0.757 -0.067 -3 0.712
GAKGAK 0.757 0.145 1 0.830
VRK2VRK2 0.757 -0.219 1 0.812
BRAFBRAF 0.756 -0.032 -4 0.699
DCAMKL2DCAMKL2 0.756 0.008 -3 0.767
PKCZPKCZ 0.755 -0.091 2 0.589
MAPKAPK5MAPKAPK5 0.755 -0.102 -3 0.620
MARK3MARK3 0.755 -0.043 4 0.751
NEK2NEK2 0.755 -0.172 2 0.605
MARK2MARK2 0.754 -0.053 4 0.717
SSTKSSTK 0.754 -0.009 4 0.784
AKT2AKT2 0.754 -0.023 -3 0.607
P70S6KP70S6K 0.754 -0.025 -3 0.628
DYRK2DYRK2 0.753 -0.068 1 0.612
GSK3AGSK3A 0.752 0.053 4 0.500
SMMLCKSMMLCK 0.752 -0.026 -3 0.756
CHAK1CHAK1 0.752 -0.168 2 0.564
SNRKSNRK 0.752 -0.150 2 0.508
GRK3GRK3 0.752 0.000 -2 0.667
MARK1MARK1 0.752 -0.057 4 0.779
NEK5NEK5 0.751 -0.100 1 0.803
JNK2JNK2 0.751 -0.029 1 0.511
MEKK3MEKK3 0.750 -0.128 1 0.729
CDK7CDK7 0.750 -0.088 1 0.576
DAPK3DAPK3 0.750 0.034 -3 0.742
JNK3JNK3 0.749 -0.047 1 0.549
GSK3BGSK3B 0.749 0.024 4 0.490
CDK1CDK1 0.749 -0.045 1 0.523
CK1ECK1E 0.749 -0.041 -3 0.521
CDK19CDK19 0.749 -0.088 1 0.525
PAK5PAK5 0.748 -0.008 -2 0.570
WNK4WNK4 0.748 -0.115 -2 0.740
PINK1PINK1 0.748 -0.133 1 0.808
PHKG2PHKG2 0.748 -0.052 -3 0.773
TAO3TAO3 0.747 -0.048 1 0.723
MEKK1MEKK1 0.747 -0.176 1 0.756
IRAK4IRAK4 0.746 -0.123 1 0.804
MEK5MEK5 0.746 -0.234 2 0.645
PAK4PAK4 0.746 -0.009 -2 0.582
DAPK1DAPK1 0.745 0.017 -3 0.713
MEKK2MEKK2 0.744 -0.150 2 0.626
AKT1AKT1 0.744 -0.018 -3 0.633
CDK13CDK13 0.744 -0.096 1 0.549
HIPK1HIPK1 0.744 -0.056 1 0.638
TTBK1TTBK1 0.744 -0.140 2 0.439
CDK18CDK18 0.744 -0.064 1 0.512
MRCKAMRCKA 0.743 0.043 -3 0.710
MST3MST3 0.743 -0.087 2 0.625
DYRK4DYRK4 0.743 -0.038 1 0.530
PKCTPKCT 0.743 -0.088 2 0.557
P38AP38A 0.743 -0.077 1 0.601
IRAK1IRAK1 0.743 -0.163 -1 0.691
ZAKZAK 0.743 -0.167 1 0.712
ERK2ERK2 0.742 -0.091 1 0.560
CAMKK1CAMKK1 0.741 -0.135 -2 0.681
HIPK2HIPK2 0.741 -0.056 1 0.530
SGK1SGK1 0.741 0.005 -3 0.516
CDK2CDK2 0.741 -0.090 1 0.604
CDK17CDK17 0.741 -0.062 1 0.451
CDK5CDK5 0.740 -0.083 1 0.598
P38BP38B 0.739 -0.064 1 0.515
CK1DCK1D 0.739 -0.042 -3 0.482
NEK8NEK8 0.739 -0.161 2 0.613
CK1A2CK1A2 0.739 -0.037 -3 0.473
PRP4PRP4 0.739 -0.089 -3 0.689
CAMK1ACAMK1A 0.739 -0.027 -3 0.606
ERK1ERK1 0.738 -0.086 1 0.516
CK1G1CK1G1 0.738 -0.090 -3 0.540
P38GP38G 0.738 -0.061 1 0.435
MRCKBMRCKB 0.738 0.015 -3 0.685
CDK16CDK16 0.738 -0.029 1 0.471
DYRK1BDYRK1B 0.738 -0.058 1 0.559
CDK9CDK9 0.738 -0.105 1 0.558
TAO2TAO2 0.738 -0.098 2 0.661
NEK11NEK11 0.737 -0.183 1 0.733
ROCK2ROCK2 0.737 0.030 -3 0.729
CAMKK2CAMKK2 0.736 -0.143 -2 0.670
DYRK1ADYRK1A 0.736 -0.098 1 0.648
PKCIPKCI 0.736 -0.094 2 0.546
DMPK1DMPK1 0.736 0.070 -3 0.722
MPSK1MPSK1 0.735 -0.077 1 0.808
CDK12CDK12 0.735 -0.100 1 0.518
DYRK3DYRK3 0.735 -0.059 1 0.647
PKCEPKCE 0.735 -0.060 2 0.523
GCKGCK 0.734 -0.074 1 0.721
MST2MST2 0.734 -0.097 1 0.722
CDK3CDK3 0.734 -0.045 1 0.470
TAK1TAK1 0.734 -0.079 1 0.766
AKT3AKT3 0.734 -0.019 -3 0.533
PDK1PDK1 0.733 -0.105 1 0.789
CDK10CDK10 0.733 -0.044 1 0.551
CDK14CDK14 0.733 -0.073 1 0.558
LKB1LKB1 0.732 -0.156 -3 0.796
CHK2CHK2 0.732 -0.059 -3 0.566
TTKTTK 0.732 0.068 -2 0.853
STK33STK33 0.731 -0.122 2 0.450
NEK4NEK4 0.731 -0.186 1 0.754
LOKLOK 0.731 -0.087 -2 0.677
EEF2KEEF2K 0.730 -0.112 3 0.685
SLKSLK 0.730 -0.073 -2 0.638
VRK1VRK1 0.730 -0.136 2 0.638
JNK1JNK1 0.730 -0.056 1 0.499
MST1MST1 0.729 -0.099 1 0.718
TNIKTNIK 0.729 -0.092 3 0.704
HIPK3HIPK3 0.729 -0.115 1 0.624
BIKEBIKE 0.729 0.100 1 0.749
NEK1NEK1 0.728 -0.145 1 0.777
ALPHAK3ALPHAK3 0.728 0.065 -1 0.705
PDHK3_TYRPDHK3_TYR 0.728 0.179 4 0.919
ERK7ERK7 0.727 -0.088 2 0.365
LRRK2LRRK2 0.727 -0.179 2 0.641
CRIKCRIK 0.727 0.017 -3 0.619
HPK1HPK1 0.727 -0.093 1 0.705
PKN1PKN1 0.727 -0.086 -3 0.651
BUB1BUB1 0.726 -0.024 -5 0.707
HGKHGK 0.726 -0.145 3 0.708
P38DP38D 0.726 -0.070 1 0.478
ROCK1ROCK1 0.725 0.011 -3 0.703
MINKMINK 0.725 -0.149 1 0.731
PDHK4_TYRPDHK4_TYR 0.724 0.161 2 0.720
SBKSBK 0.724 -0.044 -3 0.488
HASPINHASPIN 0.724 0.015 -1 0.658
PBKPBK 0.723 0.003 1 0.771
MAP3K15MAP3K15 0.723 -0.198 1 0.698
PKG1PKG1 0.722 -0.053 -2 0.521
OSR1OSR1 0.721 -0.064 2 0.627
RIPK2RIPK2 0.721 -0.209 1 0.691
MEK2MEK2 0.721 -0.216 2 0.629
BMPR2_TYRBMPR2_TYR 0.720 0.152 -1 0.806
KHS2KHS2 0.720 -0.072 1 0.721
KHS1KHS1 0.720 -0.101 1 0.711
YANK3YANK3 0.720 -0.049 2 0.301
MAP2K6_TYRMAP2K6_TYR 0.719 0.109 -1 0.762
MEKK6MEKK6 0.718 -0.247 1 0.702
YSK1YSK1 0.717 -0.162 2 0.614
MAP2K4_TYRMAP2K4_TYR 0.716 -0.002 -1 0.765
TESK1_TYRTESK1_TYR 0.716 -0.013 3 0.780
MOKMOK 0.715 -0.069 1 0.662
PDHK1_TYRPDHK1_TYR 0.715 0.065 -1 0.778
MAP2K7_TYRMAP2K7_TYR 0.714 -0.075 2 0.681
TXKTXK 0.712 0.130 1 0.741
CDK6CDK6 0.712 -0.101 1 0.543
AAK1AAK1 0.712 0.111 1 0.661
CDK4CDK4 0.712 -0.096 1 0.510
MAKMAK 0.711 -0.071 -2 0.580
PINK1_TYRPINK1_TYR 0.711 -0.046 1 0.781
PKMYT1_TYRPKMYT1_TYR 0.710 -0.097 3 0.754
EPHA6EPHA6 0.709 0.065 -1 0.812
NEK3NEK3 0.708 -0.229 1 0.713
LIMK2_TYRLIMK2_TYR 0.706 -0.071 -3 0.855
MYO3BMYO3B 0.706 -0.139 2 0.619
YES1YES1 0.705 0.056 -1 0.765
RETRET 0.704 -0.068 1 0.733
STLK3STLK3 0.704 -0.127 1 0.674
EPHA4EPHA4 0.704 0.042 2 0.632
TAO1TAO1 0.704 -0.138 1 0.662
EPHB4EPHB4 0.704 -0.012 -1 0.772
FYNFYN 0.702 0.160 -1 0.799
DDR1DDR1 0.702 -0.055 4 0.849
FERFER 0.702 -0.018 1 0.770
ABL2ABL2 0.702 0.003 -1 0.745
SRMSSRMS 0.702 0.026 1 0.739
INSRRINSRR 0.702 0.041 3 0.652
ASK1ASK1 0.701 -0.198 1 0.685
CK1ACK1A 0.701 -0.086 -3 0.407
MYO3AMYO3A 0.701 -0.158 1 0.746
LIMK1_TYRLIMK1_TYR 0.701 -0.173 2 0.668
BLKBLK 0.700 0.113 -1 0.801
TYK2TYK2 0.698 -0.155 1 0.729
FGRFGR 0.698 -0.036 1 0.786
HCKHCK 0.698 0.039 -1 0.800
MST1RMST1R 0.697 -0.134 3 0.689
LCKLCK 0.697 0.079 -1 0.806
ITKITK 0.697 -0.004 -1 0.775
FGFR2FGFR2 0.697 -0.019 3 0.723
EPHB3EPHB3 0.696 -0.004 -1 0.767
JAK3JAK3 0.696 -0.043 1 0.712
EPHB2EPHB2 0.696 0.013 -1 0.756
TYRO3TYRO3 0.696 -0.135 3 0.665
EPHB1EPHB1 0.696 -0.027 1 0.723
TECTEC 0.695 0.001 -1 0.737
BMXBMX 0.695 0.013 -1 0.740
TNK2TNK2 0.695 -0.074 3 0.659
ABL1ABL1 0.695 -0.051 -1 0.737
MERTKMERTK 0.694 -0.028 3 0.680
CSF1RCSF1R 0.694 -0.096 3 0.681
KITKIT 0.694 -0.049 3 0.693
JAK2JAK2 0.693 -0.165 1 0.718
NEK10_TYRNEK10_TYR 0.693 -0.084 1 0.620
KDRKDR 0.692 -0.053 3 0.660
YANK2YANK2 0.692 -0.052 2 0.322
EPHA5EPHA5 0.692 0.047 2 0.640
EPHA7EPHA7 0.692 0.005 2 0.625
FLT1FLT1 0.691 -0.010 -1 0.753
ROS1ROS1 0.691 -0.180 3 0.638
EPHA3EPHA3 0.690 -0.038 2 0.603
CK1G3CK1G3 0.690 -0.069 -3 0.364
AXLAXL 0.690 -0.087 3 0.687
DDR2DDR2 0.690 0.013 3 0.660
PTK2PTK2 0.689 0.101 -1 0.783
METMET 0.689 -0.041 3 0.675
FGFR3FGFR3 0.689 -0.023 3 0.700
LYNLYN 0.688 0.030 3 0.613
TEKTEK 0.687 -0.097 3 0.625
BTKBTK 0.687 -0.088 -1 0.756
ERBB2ERBB2 0.687 -0.065 1 0.672
PDGFRBPDGFRB 0.686 -0.160 3 0.682
PTK6PTK6 0.686 -0.137 -1 0.686
EPHA8EPHA8 0.686 0.028 -1 0.781
LTKLTK 0.685 -0.091 3 0.642
WEE1_TYRWEE1_TYR 0.685 -0.101 -1 0.710
FLT3FLT3 0.685 -0.119 3 0.651
TNK1TNK1 0.685 -0.139 3 0.651
NTRK1NTRK1 0.684 -0.101 -1 0.716
FGFR1FGFR1 0.684 -0.127 3 0.671
EPHA1EPHA1 0.684 -0.049 3 0.641
SRCSRC 0.683 0.024 -1 0.769
EGFREGFR 0.683 -0.005 1 0.576
PTK2BPTK2B 0.683 -0.047 -1 0.725
SYKSYK 0.682 0.073 -1 0.757
FLT4FLT4 0.681 -0.106 3 0.673
FRKFRK 0.680 -0.047 -1 0.809
CK1G2CK1G2 0.680 -0.026 -3 0.462
ALKALK 0.679 -0.143 3 0.606
INSRINSR 0.679 -0.088 3 0.621
JAK1JAK1 0.678 -0.164 1 0.668
FGFR4FGFR4 0.677 -0.028 -1 0.690
EPHA2EPHA2 0.677 0.018 -1 0.757
NTRK2NTRK2 0.677 -0.147 3 0.657
PDGFRAPDGFRA 0.676 -0.237 3 0.670
NTRK3NTRK3 0.674 -0.103 -1 0.677
TNNI3K_TYRTNNI3K_TYR 0.674 -0.202 1 0.765
MATKMATK 0.673 -0.107 -1 0.662
ERBB4ERBB4 0.673 0.015 1 0.580
IGF1RIGF1R 0.672 -0.038 3 0.577
CSKCSK 0.672 -0.111 2 0.618
FESFES 0.656 -0.111 -1 0.699
ZAP70ZAP70 0.655 -0.008 -1 0.690
MUSKMUSK 0.654 -0.171 1 0.568