Motif 591 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A4G5 | LNP1 | S114 | ochoa | Leukemia NUP98 fusion partner 1 | None |
| A4UGR9 | XIRP2 | S940 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A7KAX9 | ARHGAP32 | S1930 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| E9PAV3 | NACA | S1995 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00124 | UBXN8 | S144 | ochoa | UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) | Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}. |
| O14964 | HGS | Y334 | ochoa|psp | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| O15018 | PDZD2 | S1422 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15231 | ZNF185 | S602 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43298 | ZBTB43 | S207 | ochoa | Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) | May be involved in transcriptional regulation. |
| O60303 | KATNIP | S185 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O75152 | ZC3H11A | S543 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75348 | ATP6V1G1 | S70 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75369 | FLNB | S2497 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75554 | WBP4 | S280 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O75962 | TRIO | S1724 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94823 | ATP10B | S617 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O94923 | GLCE | S73 | ochoa | D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238, ECO:0000269|PubMed:22528493, ECO:0000269|PubMed:30872481}. |
| O95235 | KIF20A | S109 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P01834 | IGKC | S52 | ochoa | Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P02652 | APOA2 | S68 | ochoa | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] | May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. |
| P04003 | C4BPA | S187 | ochoa | C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component. |
| P04049 | RAF1 | S605 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P05198 | EIF2S1 | S91 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P05783 | KRT18 | S177 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P08237 | PFKM | S477 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P09327 | VIL1 | S724 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P12259 | F5 | S859 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P20309 | CHRM3 | S292 | ochoa | Muscarinic acetylcholine receptor M3 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| P21953 | BCKDHB | S328 | psp | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) | Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:9582350}. |
| P23193 | TCEA1 | S81 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P25685 | DNAJB1 | S171 | ochoa|psp | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P31629 | HIVEP2 | S819 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P38432 | COIL | S271 | ochoa|psp | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P40818 | USP8 | S153 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P50591 | TNFSF10 | S96 | ochoa | Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. |
| P52179 | MYOM1 | S992 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52294 | KPNA1 | S95 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P57075 | UBASH3A | S372 | ochoa | Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}. |
| P62879 | GNB2 | S136 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| P62937 | PPIA | S21 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| Q03164 | KMT2A | S2955 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05209 | PTPN12 | S397 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07157 | TJP1 | S1366 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q13188 | STK3 | S406 | ochoa | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q13228 | SELENBP1 | S286 | ochoa | Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}. |
| Q13347 | EIF3I | S177 | ochoa | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q13571 | LAPTM5 | S238 | ochoa | Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein) | May have a special functional role during embryogenesis and in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}. |
| Q13772 | NCOA4 | S554 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q14157 | UBAP2L | S634 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14494 | NFE2L1 | S599 | psp | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482). {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}.; FUNCTION: [Transcription factor NRF1]: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508). Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts. {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:15308669, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}. |
| Q14667 | BLTP2 | S2094 | ochoa | Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) | Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}. |
| Q14676 | MDC1 | S544 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14966 | ZNF638 | S299 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15746 | MYLK | S422 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q17RB8 | LONRF1 | S412 | ochoa | LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) | None |
| Q4VC05 | BCL7A | S157 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q5SW79 | CEP170 | S571 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T3I0 | GPATCH4 | S91 | ochoa | G patch domain-containing protein 4 | None |
| Q5TGY3 | AHDC1 | S179 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VUA4 | ZNF318 | S1420 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUB5 | FAM171A1 | S460 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VZK9 | CARMIL1 | S1049 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q6N043 | ZNF280D | S179 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6ZNJ1 | NBEAL2 | S1831 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRV2 | FAM83H | S785 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZV73 | FGD6 | S410 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q6ZV73 | FGD6 | S692 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7LBC6 | KDM3B | S278 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z2T5 | TRMT1L | S612 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z5L9 | IRF2BP2 | S293 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6E9 | RBBP6 | S960 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86UB2 | BIVM | S24 | ochoa | Basic immunoglobulin-like variable motif-containing protein | None |
| Q86V48 | LUZP1 | S611 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XA9 | HEATR5A | S1647 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YT6 | MIB1 | S411 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IWA0 | WDR75 | S672 | ochoa | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8N3C7 | CLIP4 | S433 | ochoa | CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) | None |
| Q8N3K9 | CMYA5 | S1982 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N567 | ZCCHC9 | S28 | ochoa | Zinc finger CCHC domain-containing protein 9 | May down-regulate transcription mediated by NF-kappa-B and the serum response element. {ECO:0000269|PubMed:18721783}. |
| Q8N5B7 | CERS5 | S356 | ochoa|psp | Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
| Q8N806 | UBR7 | S264 | ochoa | Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}. |
| Q8N983 | MRPL43 | S93 | ochoa | Large ribosomal subunit protein mL43 (39S ribosomal protein L43, mitochondrial) (L43mt) (MRP-L43) (Mitochondrial ribosomal protein bMRP36a) | None |
| Q8NFC6 | BOD1L1 | S266 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q92560 | BAP1 | S276 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92870 | APBB2 | S44 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q92953 | KCNB2 | S461 | ochoa | Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO:0000250|UniProtKB:A6H8H5, ECO:0000250|UniProtKB:Q63099}. |
| Q96EA4 | SPDL1 | S493 | ochoa | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96I25 | RBM17 | S266 | ochoa|psp | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96IZ5 | RBM41 | S260 | ochoa | RNA-binding protein 41 (RNA-binding motif protein 41) | May bind RNA. {ECO:0000305}. |
| Q96KP4 | CNDP2 | S58 | ochoa | Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:12473676, PubMed:19346245). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}. |
| Q96RV3 | PCNX1 | S198 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96S38 | RPS6KC1 | S737 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99550 | MPHOSPH9 | S937 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q99650 | OSMR | S889 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Q99741 | CDC6 | S127 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BQF6 | SENP7 | S373 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BS40 | LXN | S41 | ochoa | Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Protein MUM) (Tissue carboxypeptidase inhibitor) (TCI) | Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. {ECO:0000269|PubMed:15738388}. |
| Q9BT25 | HAUS8 | S352 | ochoa | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTC0 | DIDO1 | S123 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BXJ9 | NAA15 | S302 | ochoa | N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100) | Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306). {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| Q9BY42 | RTF2 | S235 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9BY89 | KIAA1671 | S518 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9GZY6 | LAT2 | S135 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H2Y7 | ZNF106 | S508 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H501 | ESF1 | S823 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H582 | ZNF644 | S753 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H814 | PHAX | S149 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9HAV0 | GNB4 | S136 | ochoa | Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q9HAW4 | CLSPN | S703 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HC35 | EML4 | S94 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NQW6 | ANLN | S349 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRP2 | CMC2 | S59 | ochoa | COX assembly mitochondrial protein 2 homolog | May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}. |
| Q9P2D0 | IBTK | S1203 | psp | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UDY4 | DNAJB4 | S167 | ochoa | DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| Q9UHR4 | BAIAP2L1 | S132 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UKW4 | VAV3 | S213 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9ULD5 | ZNF777 | S604 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9UPU7 | TBC1D2B | S577 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UPV0 | CEP164 | S383 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2H9 | MAST1 | S717 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I7 | PIKFYVE | S710 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y4C1 | KDM3A | S264 | ochoa|psp | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| Q9Y5Z4 | HEBP2 | S37 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| R4GMW8 | BIVM-ERCC5 | S24 | ochoa | DNA excision repair protein ERCC-5 | None |
| O00444 | PLK4 | S443 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P63167 | DYNLL1 | S21 | Sugiyama | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (PubMed:10198631, PubMed:15193260, PubMed:15891768, PubMed:16684779, PubMed:30464262, PubMed:37696958). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (PubMed:30464262, PubMed:37696958). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (PubMed:37696958). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (PubMed:15891768, PubMed:16684779). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (PubMed:10198631, PubMed:15193260). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (PubMed:10198631, PubMed:15193260). {ECO:0000250|UniProtKB:P61285, ECO:0000250|UniProtKB:P63170, ECO:0000269|PubMed:10198631, ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:37696958}. |
| O95881 | TXNDC12 | S143 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
| P33176 | KIF5B | S57 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| Q13765 | NACA | S132 | Sugiyama | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| Q13546 | RIPK1 | S20 | SIGNOR|EPSD|PSP | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q9NZV8 | KCND2 | S459 | ELM | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:35597238}. |
| Q53SF7 | COBLL1 | S876 | PSP | Cordon-bleu protein-like 1 | None |
| Q96PY6 | NEK1 | S23 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.000546 | 3.263 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.000546 | 3.263 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.000657 | 3.182 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.000981 | 3.008 |
| R-HSA-380287 | Centrosome maturation | 0.001093 | 2.962 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.001277 | 2.894 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.001712 | 2.766 |
| R-HSA-75153 | Apoptotic execution phase | 0.001654 | 2.782 |
| R-HSA-109581 | Apoptosis | 0.001482 | 2.829 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.002151 | 2.667 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.002348 | 2.629 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.002558 | 2.592 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003660 | 2.436 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.005620 | 2.250 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.004751 | 2.323 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.004751 | 2.323 |
| R-HSA-5357801 | Programmed Cell Death | 0.005035 | 2.298 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005393 | 2.268 |
| R-HSA-162592 | Integration of provirus | 0.008625 | 2.064 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.008497 | 2.071 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.053662 | 1.270 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.013512 | 1.869 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.019334 | 1.714 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.033496 | 1.475 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.033496 | 1.475 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.033496 | 1.475 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.055242 | 1.258 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.016310 | 1.788 |
| R-HSA-202040 | G-protein activation | 0.024270 | 1.615 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.050574 | 1.296 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.026108 | 1.583 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.014882 | 1.827 |
| R-HSA-191650 | Regulation of gap junction activity | 0.053662 | 1.270 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.024270 | 1.615 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.031556 | 1.501 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.024270 | 1.615 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.035481 | 1.450 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.055242 | 1.258 |
| R-HSA-392518 | Signal amplification | 0.055242 | 1.258 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.044921 | 1.348 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.053662 | 1.270 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.020927 | 1.679 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.050574 | 1.296 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.044921 | 1.348 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.053662 | 1.270 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.019334 | 1.714 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.029662 | 1.528 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.031556 | 1.501 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.048297 | 1.316 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.035481 | 1.450 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.043860 | 1.358 |
| R-HSA-983189 | Kinesins | 0.025350 | 1.596 |
| R-HSA-73887 | Death Receptor Signaling | 0.021947 | 1.659 |
| R-HSA-9635644 | Inhibition of membrane repair | 0.027198 | 1.565 |
| R-HSA-77387 | Insulin receptor recycling | 0.039585 | 1.402 |
| R-HSA-182971 | EGFR downregulation | 0.046058 | 1.337 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.043860 | 1.358 |
| R-HSA-5617833 | Cilium Assembly | 0.044670 | 1.350 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.055198 | 1.258 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.035481 | 1.450 |
| R-HSA-2028269 | Signaling by Hippo | 0.017794 | 1.750 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.050574 | 1.296 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.048528 | 1.314 |
| R-HSA-210991 | Basigin interactions | 0.024270 | 1.615 |
| R-HSA-1296071 | Potassium Channels | 0.017591 | 1.755 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.022572 | 1.646 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.022572 | 1.646 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.039585 | 1.402 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.052890 | 1.277 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.027816 | 1.556 |
| R-HSA-68886 | M Phase | 0.033487 | 1.475 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.021697 | 1.664 |
| R-HSA-983712 | Ion channel transport | 0.043921 | 1.357 |
| R-HSA-69275 | G2/M Transition | 0.041723 | 1.380 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.043181 | 1.365 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.044303 | 1.354 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.041702 | 1.380 |
| R-HSA-3214842 | HDMs demethylate histones | 0.033496 | 1.475 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.045299 | 1.344 |
| R-HSA-1640170 | Cell Cycle | 0.017412 | 1.759 |
| R-HSA-1538133 | G0 and Early G1 | 0.048297 | 1.316 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.043860 | 1.358 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.039355 | 1.405 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.038425 | 1.415 |
| R-HSA-164525 | Plus-strand DNA synthesis | 0.070906 | 1.149 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.070906 | 1.149 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 0.070906 | 1.149 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 0.070906 | 1.149 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 0.070906 | 1.149 |
| R-HSA-162585 | Uncoating of the HIV Virion | 0.079410 | 1.100 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.079410 | 1.100 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.079410 | 1.100 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 0.079410 | 1.100 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.087837 | 1.056 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.087837 | 1.056 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.087837 | 1.056 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.087837 | 1.056 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 0.096188 | 1.017 |
| R-HSA-164516 | Minus-strand DNA synthesis | 0.096188 | 1.017 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.096188 | 1.017 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.096188 | 1.017 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.104462 | 0.981 |
| R-HSA-173107 | Binding and entry of HIV virion | 0.112662 | 0.948 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.120787 | 0.918 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.128838 | 0.890 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.136815 | 0.864 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 0.152553 | 0.817 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.160315 | 0.795 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.062514 | 1.204 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.198079 | 0.703 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.077948 | 1.108 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.205426 | 0.687 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.212707 | 0.672 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.088829 | 1.051 |
| R-HSA-72649 | Translation initiation complex formation | 0.111802 | 0.952 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.056527 | 1.248 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.056527 | 1.248 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.117767 | 0.929 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.261850 | 0.582 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.261850 | 0.582 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.261850 | 0.582 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.268618 | 0.571 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.268618 | 0.571 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.264904 | 0.577 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.255021 | 0.593 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.258120 | 0.588 |
| R-HSA-75158 | TRAIL signaling | 0.070906 | 1.149 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.281967 | 0.550 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.175628 | 0.755 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.065007 | 1.187 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.128838 | 0.890 |
| R-HSA-8963901 | Chylomicron remodeling | 0.144720 | 0.839 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.108851 | 0.963 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.126859 | 0.897 |
| R-HSA-5673000 | RAF activation | 0.314293 | 0.503 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.167918 | 0.775 |
| R-HSA-8963888 | Chylomicron assembly | 0.120787 | 0.918 |
| R-HSA-3371568 | Attenuation phase | 0.070090 | 1.154 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.083413 | 1.079 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.211114 | 0.675 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.151846 | 0.819 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.112662 | 0.948 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.144720 | 0.839 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.160315 | 0.795 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.103014 | 0.987 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.288551 | 0.540 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.332990 | 0.478 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.305549 | 0.515 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.255021 | 0.593 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.332438 | 0.478 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.087837 | 1.056 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.183180 | 0.737 |
| R-HSA-3295583 | TRP channels | 0.255021 | 0.593 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.160315 | 0.795 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.302172 | 0.520 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.062323 | 1.205 |
| R-HSA-9634597 | GPER1 signaling | 0.094429 | 1.025 |
| R-HSA-162587 | HIV Life Cycle | 0.218255 | 0.661 |
| R-HSA-9711097 | Cellular response to starvation | 0.220646 | 0.656 |
| R-HSA-5218859 | Regulated Necrosis | 0.155036 | 0.810 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.136815 | 0.864 |
| R-HSA-991365 | Activation of GABAB receptors | 0.077948 | 1.108 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.220925 | 0.656 |
| R-HSA-2424491 | DAP12 signaling | 0.281967 | 0.550 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.315660 | 0.501 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.244562 | 0.612 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.070906 | 1.149 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.104462 | 0.981 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.120787 | 0.918 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.077948 | 1.108 |
| R-HSA-977444 | GABA B receptor activation | 0.077948 | 1.108 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.123810 | 0.907 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.281967 | 0.550 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.302172 | 0.520 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.302172 | 0.520 |
| R-HSA-418597 | G alpha (z) signalling events | 0.114775 | 0.940 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.128756 | 0.890 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.248129 | 0.605 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.248129 | 0.605 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.259549 | 0.586 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.259549 | 0.586 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.208746 | 0.680 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.144720 | 0.839 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.175628 | 0.755 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.278473 | 0.555 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.326815 | 0.486 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.241174 | 0.618 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.301540 | 0.521 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.057631 | 1.239 |
| R-HSA-422356 | Regulation of insulin secretion | 0.080007 | 1.097 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.087837 | 1.056 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.112662 | 0.948 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.128838 | 0.890 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.086068 | 1.065 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.234154 | 0.630 |
| R-HSA-429947 | Deadenylation of mRNA | 0.241174 | 0.618 |
| R-HSA-977443 | GABA receptor activation | 0.129926 | 0.886 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.275323 | 0.560 |
| R-HSA-391251 | Protein folding | 0.241177 | 0.618 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.235103 | 0.629 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.205426 | 0.687 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.197503 | 0.704 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.104462 | 0.981 |
| R-HSA-9658195 | Leishmania infection | 0.300107 | 0.523 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.300107 | 0.523 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.152553 | 0.817 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.160315 | 0.795 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.086068 | 1.065 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.301540 | 0.521 |
| R-HSA-4086398 | Ca2+ pathway | 0.171168 | 0.767 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.057631 | 1.239 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.190663 | 0.720 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.255021 | 0.593 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.076662 | 1.115 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.155036 | 0.810 |
| R-HSA-381042 | PERK regulates gene expression | 0.320582 | 0.494 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.104462 | 0.981 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.136815 | 0.864 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.136815 | 0.864 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.152553 | 0.817 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.183180 | 0.737 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.288551 | 0.540 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.332990 | 0.478 |
| R-HSA-69481 | G2/M Checkpoints | 0.143349 | 0.844 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.204493 | 0.689 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.241174 | 0.618 |
| R-HSA-5688426 | Deubiquitination | 0.110794 | 0.955 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.248129 | 0.605 |
| R-HSA-163685 | Integration of energy metabolism | 0.167311 | 0.776 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.191609 | 0.718 |
| R-HSA-392517 | Rap1 signalling | 0.198079 | 0.703 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.326815 | 0.486 |
| R-HSA-3371511 | HSF1 activation | 0.326815 | 0.486 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.332990 | 0.478 |
| R-HSA-416476 | G alpha (q) signalling events | 0.122255 | 0.913 |
| R-HSA-109582 | Hemostasis | 0.068323 | 1.165 |
| R-HSA-177929 | Signaling by EGFR | 0.117767 | 0.929 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.104820 | 0.980 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.080627 | 1.094 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.129926 | 0.886 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.298793 | 0.525 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.298793 | 0.525 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.136815 | 0.864 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.160315 | 0.795 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.177697 | 0.750 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.326815 | 0.486 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.101928 | 0.992 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.302172 | 0.520 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.133010 | 0.876 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.241174 | 0.618 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.326815 | 0.486 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.219922 | 0.658 |
| R-HSA-4839726 | Chromatin organization | 0.235572 | 0.628 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.096188 | 1.017 |
| R-HSA-9842663 | Signaling by LTK | 0.136815 | 0.864 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.210854 | 0.676 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.194182 | 0.712 |
| R-HSA-418346 | Platelet homeostasis | 0.295411 | 0.530 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.212707 | 0.672 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.241177 | 0.618 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.322383 | 0.492 |
| R-HSA-111885 | Opioid Signalling | 0.285253 | 0.545 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.143958 | 0.842 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.295411 | 0.530 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.212707 | 0.672 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.219922 | 0.658 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.275082 | 0.561 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.060055 | 1.221 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.227070 | 0.644 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.307946 | 0.512 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.325739 | 0.487 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.227070 | 0.644 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.219922 | 0.658 |
| R-HSA-917937 | Iron uptake and transport | 0.177697 | 0.750 |
| R-HSA-264876 | Insulin processing | 0.261850 | 0.582 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.241177 | 0.618 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.285253 | 0.545 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.201679 | 0.695 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.281967 | 0.550 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.322383 | 0.492 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.255021 | 0.593 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.314293 | 0.503 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.211114 | 0.675 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.231036 | 0.636 |
| R-HSA-6806834 | Signaling by MET | 0.194182 | 0.712 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.145508 | 0.837 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.174427 | 0.758 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.081702 | 1.088 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.180977 | 0.742 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.281967 | 0.550 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.220925 | 0.656 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.334320 | 0.476 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.335780 | 0.474 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.335780 | 0.474 |
| R-HSA-5693538 | Homology Directed Repair | 0.342450 | 0.465 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.345172 | 0.462 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.345172 | 0.462 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.345172 | 0.462 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.351181 | 0.454 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.351181 | 0.454 |
| R-HSA-9646399 | Aggrephagy | 0.351181 | 0.454 |
| R-HSA-167169 | HIV Transcription Elongation | 0.351181 | 0.454 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.351181 | 0.454 |
| R-HSA-3371556 | Cellular response to heat stress | 0.352416 | 0.453 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.352416 | 0.453 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.357134 | 0.447 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.357134 | 0.447 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.357134 | 0.447 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.357134 | 0.447 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.361826 | 0.441 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.362329 | 0.441 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.363033 | 0.440 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.363033 | 0.440 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.363033 | 0.440 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.365346 | 0.437 |
| R-HSA-977606 | Regulation of Complement cascade | 0.365622 | 0.437 |
| R-HSA-69206 | G1/S Transition | 0.368908 | 0.433 |
| R-HSA-68882 | Mitotic Anaphase | 0.369305 | 0.433 |
| R-HSA-162582 | Signal Transduction | 0.370928 | 0.431 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.371794 | 0.430 |
| R-HSA-114608 | Platelet degranulation | 0.375459 | 0.425 |
| R-HSA-2172127 | DAP12 interactions | 0.380410 | 0.420 |
| R-HSA-373752 | Netrin-1 signaling | 0.380410 | 0.420 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.380410 | 0.420 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.380410 | 0.420 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.386097 | 0.413 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.387242 | 0.412 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.391732 | 0.407 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.391732 | 0.407 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.391732 | 0.407 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.391732 | 0.407 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.391732 | 0.407 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.391732 | 0.407 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.391732 | 0.407 |
| R-HSA-162906 | HIV Infection | 0.396580 | 0.402 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.397315 | 0.401 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.398167 | 0.400 |
| R-HSA-5620924 | Intraflagellar transport | 0.402848 | 0.395 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.402848 | 0.395 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.402848 | 0.395 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.408330 | 0.389 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.410973 | 0.386 |
| R-HSA-9748787 | Azathioprine ADME | 0.413763 | 0.383 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.413781 | 0.383 |
| R-HSA-199991 | Membrane Trafficking | 0.418050 | 0.379 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.419146 | 0.378 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.421108 | 0.376 |
| R-HSA-9664407 | Parasite infection | 0.423645 | 0.373 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.423645 | 0.373 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.423645 | 0.373 |
| R-HSA-72187 | mRNA 3'-end processing | 0.424479 | 0.372 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.424479 | 0.372 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.424479 | 0.372 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.424479 | 0.372 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.426792 | 0.370 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.429764 | 0.367 |
| R-HSA-1221632 | Meiotic synapsis | 0.429764 | 0.367 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.429764 | 0.367 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.433058 | 0.363 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.435001 | 0.362 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.440190 | 0.356 |
| R-HSA-9753281 | Paracetamol ADME | 0.440190 | 0.356 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.440190 | 0.356 |
| R-HSA-382551 | Transport of small molecules | 0.440988 | 0.356 |
| R-HSA-166658 | Complement cascade | 0.442389 | 0.354 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.445332 | 0.351 |
| R-HSA-75893 | TNF signaling | 0.445332 | 0.351 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.445332 | 0.351 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.445332 | 0.351 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.445480 | 0.351 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.448563 | 0.348 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.450427 | 0.346 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.455475 | 0.342 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.455475 | 0.342 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.457752 | 0.339 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.460477 | 0.337 |
| R-HSA-191859 | snRNP Assembly | 0.460477 | 0.337 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.460477 | 0.337 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.460477 | 0.337 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.460477 | 0.337 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.462932 | 0.334 |
| R-HSA-73894 | DNA Repair | 0.463020 | 0.334 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.463829 | 0.334 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.465434 | 0.332 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.465434 | 0.332 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.465434 | 0.332 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.465434 | 0.332 |
| R-HSA-156590 | Glutathione conjugation | 0.465434 | 0.332 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.465434 | 0.332 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.465434 | 0.332 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.465434 | 0.332 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.465434 | 0.332 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.465434 | 0.332 |
| R-HSA-69306 | DNA Replication | 0.466853 | 0.331 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.470345 | 0.328 |
| R-HSA-1989781 | PPARA activates gene expression | 0.472870 | 0.325 |
| R-HSA-1268020 | Mitochondrial protein import | 0.475212 | 0.323 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.475212 | 0.323 |
| R-HSA-186797 | Signaling by PDGF | 0.475212 | 0.323 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.478847 | 0.320 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.480034 | 0.319 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.481820 | 0.317 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.484812 | 0.314 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.484812 | 0.314 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.489547 | 0.310 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.494238 | 0.306 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.495122 | 0.305 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.498887 | 0.302 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.503493 | 0.298 |
| R-HSA-167172 | Transcription of the HIV genome | 0.503493 | 0.298 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.503493 | 0.298 |
| R-HSA-913531 | Interferon Signaling | 0.510464 | 0.292 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.512579 | 0.290 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.512579 | 0.290 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.512579 | 0.290 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.517060 | 0.286 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.519770 | 0.284 |
| R-HSA-1280218 | Adaptive Immune System | 0.521185 | 0.283 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.521500 | 0.283 |
| R-HSA-418555 | G alpha (s) signalling events | 0.522332 | 0.282 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.525900 | 0.279 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.525900 | 0.279 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.530259 | 0.276 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.530259 | 0.276 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.530736 | 0.275 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.533515 | 0.273 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.534579 | 0.272 |
| R-HSA-5689603 | UCH proteinases | 0.538859 | 0.269 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.538859 | 0.269 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.543100 | 0.265 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.549274 | 0.260 |
| R-HSA-9659379 | Sensory processing of sound | 0.551466 | 0.258 |
| R-HSA-9833482 | PKR-mediated signaling | 0.555592 | 0.255 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.559680 | 0.252 |
| R-HSA-195721 | Signaling by WNT | 0.561382 | 0.251 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.563731 | 0.249 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.571721 | 0.243 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.575662 | 0.240 |
| R-HSA-1500620 | Meiosis | 0.575662 | 0.240 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.583436 | 0.234 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.584172 | 0.233 |
| R-HSA-70268 | Pyruvate metabolism | 0.587270 | 0.231 |
| R-HSA-168249 | Innate Immune System | 0.590973 | 0.228 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 0.591068 | 0.228 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.591068 | 0.228 |
| R-HSA-9663891 | Selective autophagy | 0.591068 | 0.228 |
| R-HSA-168256 | Immune System | 0.591538 | 0.228 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.604265 | 0.219 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.609547 | 0.215 |
| R-HSA-72172 | mRNA Splicing | 0.611610 | 0.214 |
| R-HSA-2029481 | FCGR activation | 0.613142 | 0.212 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.613142 | 0.212 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.620233 | 0.207 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.623730 | 0.205 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.623730 | 0.205 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.627195 | 0.203 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.627195 | 0.203 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.627195 | 0.203 |
| R-HSA-397014 | Muscle contraction | 0.630691 | 0.200 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.630691 | 0.200 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.634031 | 0.198 |
| R-HSA-70171 | Glycolysis | 0.640742 | 0.193 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.640742 | 0.193 |
| R-HSA-6798695 | Neutrophil degranulation | 0.643039 | 0.192 |
| R-HSA-9748784 | Drug ADME | 0.644522 | 0.191 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.647331 | 0.189 |
| R-HSA-1483255 | PI Metabolism | 0.647331 | 0.189 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.647331 | 0.189 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.650580 | 0.187 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.653800 | 0.185 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.653800 | 0.185 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.658117 | 0.182 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.660151 | 0.180 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.660151 | 0.180 |
| R-HSA-112316 | Neuronal System | 0.660642 | 0.180 |
| R-HSA-166786 | Creation of C4 and C2 activators | 0.663283 | 0.178 |
| R-HSA-69239 | Synthesis of DNA | 0.666386 | 0.176 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.672508 | 0.172 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.675526 | 0.170 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.675526 | 0.170 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.682449 | 0.166 |
| R-HSA-8939211 | ESR-mediated signaling | 0.685640 | 0.164 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.686206 | 0.164 |
| R-HSA-166663 | Initial triggering of complement | 0.690211 | 0.161 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.695898 | 0.157 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.695898 | 0.157 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.695898 | 0.157 |
| R-HSA-70326 | Glucose metabolism | 0.701481 | 0.154 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.701481 | 0.154 |
| R-HSA-449147 | Signaling by Interleukins | 0.711881 | 0.148 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.717628 | 0.144 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.720234 | 0.143 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.725373 | 0.139 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.725373 | 0.139 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.725373 | 0.139 |
| R-HSA-194138 | Signaling by VEGF | 0.725373 | 0.139 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.727908 | 0.138 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.735544 | 0.133 |
| R-HSA-1474165 | Reproduction | 0.740236 | 0.131 |
| R-HSA-5576891 | Cardiac conduction | 0.742634 | 0.129 |
| R-HSA-9843745 | Adipogenesis | 0.742634 | 0.129 |
| R-HSA-388396 | GPCR downstream signalling | 0.743537 | 0.129 |
| R-HSA-9909396 | Circadian clock | 0.745010 | 0.128 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.751642 | 0.124 |
| R-HSA-5368287 | Mitochondrial translation | 0.761045 | 0.119 |
| R-HSA-6807070 | PTEN Regulation | 0.763252 | 0.117 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.763252 | 0.117 |
| R-HSA-422475 | Axon guidance | 0.767272 | 0.115 |
| R-HSA-1632852 | Macroautophagy | 0.767606 | 0.115 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.767640 | 0.115 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.773989 | 0.111 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.776077 | 0.110 |
| R-HSA-9679506 | SARS-CoV Infections | 0.779010 | 0.108 |
| R-HSA-2187338 | Visual phototransduction | 0.782229 | 0.107 |
| R-HSA-69242 | S Phase | 0.784242 | 0.106 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.784242 | 0.106 |
| R-HSA-72766 | Translation | 0.785264 | 0.105 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.788212 | 0.103 |
| R-HSA-9609507 | Protein localization | 0.794032 | 0.100 |
| R-HSA-9612973 | Autophagy | 0.799694 | 0.097 |
| R-HSA-8953854 | Metabolism of RNA | 0.803809 | 0.095 |
| R-HSA-877300 | Interferon gamma signaling | 0.805200 | 0.094 |
| R-HSA-9675108 | Nervous system development | 0.808392 | 0.092 |
| R-HSA-372790 | Signaling by GPCR | 0.822683 | 0.085 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.825604 | 0.083 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.825764 | 0.083 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.827376 | 0.082 |
| R-HSA-74160 | Gene expression (Transcription) | 0.827491 | 0.082 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.828975 | 0.081 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.830558 | 0.081 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.830558 | 0.081 |
| R-HSA-168255 | Influenza Infection | 0.839757 | 0.076 |
| R-HSA-2559583 | Cellular Senescence | 0.841242 | 0.075 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.845613 | 0.073 |
| R-HSA-2262752 | Cellular responses to stress | 0.847579 | 0.072 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.852634 | 0.069 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.856694 | 0.067 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.859338 | 0.066 |
| R-HSA-9609690 | HCMV Early Events | 0.863214 | 0.064 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.863214 | 0.064 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.868218 | 0.061 |
| R-HSA-428157 | Sphingolipid metabolism | 0.869440 | 0.061 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.871851 | 0.060 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.874810 | 0.058 |
| R-HSA-6805567 | Keratinization | 0.876541 | 0.057 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.888089 | 0.052 |
| R-HSA-418990 | Adherens junctions interactions | 0.889611 | 0.051 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.893762 | 0.049 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.899446 | 0.046 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.900380 | 0.046 |
| R-HSA-72312 | rRNA processing | 0.903132 | 0.044 |
| R-HSA-418594 | G alpha (i) signalling events | 0.906452 | 0.043 |
| R-HSA-9824446 | Viral Infection Pathways | 0.909207 | 0.041 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.909262 | 0.041 |
| R-HSA-157118 | Signaling by NOTCH | 0.910105 | 0.041 |
| R-HSA-597592 | Post-translational protein modification | 0.913560 | 0.039 |
| R-HSA-392499 | Metabolism of proteins | 0.913925 | 0.039 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.916465 | 0.038 |
| R-HSA-9609646 | HCMV Infection | 0.918125 | 0.037 |
| R-HSA-421270 | Cell-cell junction organization | 0.918887 | 0.037 |
| R-HSA-212436 | Generic Transcription Pathway | 0.921395 | 0.036 |
| R-HSA-500792 | GPCR ligand binding | 0.921941 | 0.035 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.922592 | 0.035 |
| R-HSA-5663205 | Infectious disease | 0.924773 | 0.034 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.935079 | 0.029 |
| R-HSA-446728 | Cell junction organization | 0.936994 | 0.028 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.943163 | 0.025 |
| R-HSA-1483257 | Phospholipid metabolism | 0.946271 | 0.024 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.946271 | 0.024 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.946772 | 0.024 |
| R-HSA-1500931 | Cell-Cell communication | 0.955878 | 0.020 |
| R-HSA-1266738 | Developmental Biology | 0.957468 | 0.019 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.965113 | 0.015 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.965440 | 0.015 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.967642 | 0.014 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.971902 | 0.012 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.979020 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.979606 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 0.984638 | 0.007 |
| R-HSA-1643685 | Disease | 0.985820 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.993819 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.997503 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999660 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999920 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.856 | 0.777 | 2 | 0.899 |
CLK3 |
0.817 | 0.210 | 1 | 0.846 |
COT |
0.817 | 0.044 | 2 | 0.364 |
MNK2 |
0.812 | 0.191 | -2 | 0.924 |
CAMK1B |
0.812 | 0.117 | -3 | 0.835 |
AURC |
0.811 | 0.211 | -2 | 0.868 |
WNK1 |
0.810 | 0.108 | -2 | 0.882 |
PRKD2 |
0.809 | 0.089 | -3 | 0.743 |
PIM3 |
0.808 | 0.073 | -3 | 0.780 |
MST4 |
0.808 | 0.057 | 2 | 0.313 |
SKMLCK |
0.808 | 0.217 | -2 | 0.921 |
PIM1 |
0.808 | 0.118 | -3 | 0.748 |
DSTYK |
0.807 | 0.068 | 2 | 0.404 |
PKCD |
0.807 | 0.080 | 2 | 0.266 |
PKN3 |
0.807 | 0.065 | -3 | 0.785 |
MARK4 |
0.807 | 0.093 | 4 | 0.877 |
PKACG |
0.807 | 0.155 | -2 | 0.886 |
PRKD1 |
0.806 | 0.056 | -3 | 0.770 |
CAMK2G |
0.806 | 0.097 | 2 | 0.402 |
RSK2 |
0.806 | 0.098 | -3 | 0.733 |
PAK6 |
0.806 | 0.171 | -2 | 0.898 |
MNK1 |
0.805 | 0.166 | -2 | 0.924 |
TSSK2 |
0.805 | 0.097 | -5 | 0.861 |
NDR1 |
0.805 | 0.053 | -3 | 0.796 |
CAMK2D |
0.805 | 0.149 | -3 | 0.817 |
PKN2 |
0.805 | 0.046 | -3 | 0.815 |
NLK |
0.804 | 0.025 | 1 | 0.870 |
CAMK2B |
0.804 | 0.206 | 2 | 0.497 |
AURB |
0.804 | 0.203 | -2 | 0.869 |
TSSK1 |
0.804 | 0.080 | -3 | 0.841 |
ULK2 |
0.803 | -0.105 | 2 | 0.264 |
RSK3 |
0.803 | 0.073 | -3 | 0.724 |
P70S6KB |
0.802 | 0.078 | -3 | 0.774 |
NDR2 |
0.802 | 0.012 | -3 | 0.787 |
CAMLCK |
0.802 | 0.161 | -2 | 0.933 |
PAK1 |
0.801 | 0.136 | -2 | 0.917 |
PKACB |
0.801 | 0.187 | -2 | 0.873 |
PDHK4 |
0.801 | 0.056 | 1 | 0.858 |
SRPK1 |
0.801 | 0.081 | -3 | 0.695 |
CLK4 |
0.801 | 0.165 | -3 | 0.744 |
AMPKA1 |
0.801 | 0.053 | -3 | 0.827 |
RAF1 |
0.801 | -0.035 | 1 | 0.842 |
PRPK |
0.801 | -0.057 | -1 | 0.812 |
P90RSK |
0.800 | 0.051 | -3 | 0.727 |
NUAK2 |
0.800 | 0.014 | -3 | 0.815 |
CLK1 |
0.800 | 0.138 | -3 | 0.733 |
NIK |
0.800 | 0.057 | -3 | 0.854 |
RIPK3 |
0.800 | 0.030 | 3 | 0.723 |
PAK3 |
0.800 | 0.117 | -2 | 0.917 |
CLK2 |
0.799 | 0.179 | -3 | 0.719 |
MYLK4 |
0.799 | 0.171 | -2 | 0.922 |
MTOR |
0.799 | -0.060 | 1 | 0.830 |
MAPKAPK3 |
0.798 | 0.038 | -3 | 0.748 |
TBK1 |
0.798 | -0.047 | 1 | 0.774 |
PKG2 |
0.798 | 0.161 | -2 | 0.861 |
PRKD3 |
0.798 | 0.063 | -3 | 0.721 |
DAPK2 |
0.798 | 0.124 | -3 | 0.834 |
CAMK4 |
0.798 | 0.071 | -3 | 0.812 |
CDKL1 |
0.798 | 0.015 | -3 | 0.750 |
ATR |
0.798 | 0.043 | 1 | 0.847 |
GCN2 |
0.798 | -0.177 | 2 | 0.274 |
HUNK |
0.797 | -0.061 | 2 | 0.275 |
MSK2 |
0.797 | 0.108 | -3 | 0.692 |
IKKB |
0.797 | -0.042 | -2 | 0.730 |
WNK3 |
0.797 | -0.042 | 1 | 0.828 |
PRKX |
0.797 | 0.185 | -3 | 0.659 |
PKCA |
0.796 | 0.032 | 2 | 0.230 |
MSK1 |
0.796 | 0.160 | -3 | 0.702 |
PKCB |
0.796 | 0.017 | 2 | 0.235 |
NIM1 |
0.795 | -0.023 | 3 | 0.770 |
RSK4 |
0.795 | 0.108 | -3 | 0.694 |
PKCG |
0.795 | 0.021 | 2 | 0.233 |
CDC7 |
0.795 | -0.070 | 1 | 0.790 |
QSK |
0.795 | 0.050 | 4 | 0.869 |
QIK |
0.795 | 0.019 | -3 | 0.821 |
MELK |
0.795 | 0.024 | -3 | 0.793 |
AMPKA2 |
0.795 | 0.040 | -3 | 0.798 |
ICK |
0.795 | 0.051 | -3 | 0.781 |
MARK3 |
0.794 | 0.072 | 4 | 0.830 |
MAPKAPK2 |
0.794 | 0.065 | -3 | 0.692 |
LATS2 |
0.794 | 0.028 | -5 | 0.766 |
ULK1 |
0.794 | -0.118 | -3 | 0.785 |
MARK2 |
0.794 | 0.082 | 4 | 0.808 |
CAMK2A |
0.793 | 0.097 | 2 | 0.418 |
PDHK1 |
0.793 | -0.109 | 1 | 0.846 |
CDKL5 |
0.793 | -0.001 | -3 | 0.742 |
PKCZ |
0.793 | 0.046 | 2 | 0.248 |
BMPR2 |
0.793 | -0.088 | -2 | 0.827 |
MARK1 |
0.793 | 0.080 | 4 | 0.857 |
SIK |
0.792 | 0.035 | -3 | 0.747 |
NUAK1 |
0.792 | 0.001 | -3 | 0.776 |
BRSK1 |
0.792 | 0.027 | -3 | 0.769 |
PAK2 |
0.792 | 0.116 | -2 | 0.909 |
PKCH |
0.792 | 0.021 | 2 | 0.221 |
AURA |
0.792 | 0.198 | -2 | 0.850 |
SSTK |
0.792 | 0.088 | 4 | 0.872 |
IKKE |
0.791 | -0.074 | 1 | 0.769 |
HIPK4 |
0.791 | 0.012 | 1 | 0.821 |
CHAK2 |
0.791 | -0.031 | -1 | 0.889 |
SGK3 |
0.791 | 0.089 | -3 | 0.731 |
SRPK2 |
0.791 | 0.058 | -3 | 0.631 |
RIPK1 |
0.791 | 0.015 | 1 | 0.836 |
NEK7 |
0.791 | -0.141 | -3 | 0.814 |
CAMK1G |
0.790 | 0.052 | -3 | 0.749 |
MOS |
0.790 | -0.064 | 1 | 0.817 |
BRSK2 |
0.790 | 0.006 | -3 | 0.808 |
ERK5 |
0.790 | -0.034 | 1 | 0.822 |
AKT2 |
0.790 | 0.100 | -3 | 0.667 |
NEK6 |
0.790 | -0.111 | -2 | 0.795 |
TGFBR2 |
0.790 | -0.080 | -2 | 0.734 |
BCKDK |
0.789 | -0.067 | -1 | 0.754 |
PKACA |
0.788 | 0.170 | -2 | 0.844 |
PIM2 |
0.788 | 0.082 | -3 | 0.724 |
NEK2 |
0.788 | -0.041 | 2 | 0.250 |
ATM |
0.788 | 0.087 | 1 | 0.797 |
LATS1 |
0.787 | 0.169 | -3 | 0.786 |
PKCI |
0.787 | 0.070 | 2 | 0.232 |
PKCT |
0.787 | 0.046 | 2 | 0.225 |
MLK1 |
0.787 | -0.134 | 2 | 0.290 |
AKT1 |
0.786 | 0.128 | -3 | 0.687 |
PHKG1 |
0.786 | -0.040 | -3 | 0.804 |
IRE1 |
0.786 | -0.076 | 1 | 0.797 |
IKKA |
0.786 | -0.018 | -2 | 0.695 |
PHKG2 |
0.786 | 0.025 | -3 | 0.801 |
CAMK1D |
0.786 | 0.112 | -3 | 0.688 |
SNRK |
0.786 | -0.067 | 2 | 0.210 |
PAK5 |
0.785 | 0.144 | -2 | 0.849 |
DYRK2 |
0.784 | 0.063 | 1 | 0.760 |
DNAPK |
0.784 | 0.131 | 1 | 0.763 |
NEK9 |
0.784 | -0.160 | 2 | 0.272 |
IRE2 |
0.784 | -0.063 | 2 | 0.231 |
CHK1 |
0.784 | 0.037 | -3 | 0.797 |
PKR |
0.783 | 0.013 | 1 | 0.832 |
CDK5 |
0.783 | 0.050 | 1 | 0.750 |
MASTL |
0.783 | -0.163 | -2 | 0.783 |
ANKRD3 |
0.783 | -0.107 | 1 | 0.874 |
CDK8 |
0.782 | 0.014 | 1 | 0.737 |
SMMLCK |
0.782 | 0.130 | -3 | 0.791 |
MLK2 |
0.782 | -0.132 | 2 | 0.288 |
GRK6 |
0.782 | -0.018 | 1 | 0.827 |
CHAK1 |
0.781 | -0.082 | 2 | 0.226 |
DCAMKL2 |
0.781 | 0.018 | -3 | 0.801 |
DCAMKL1 |
0.781 | 0.028 | -3 | 0.766 |
PAK4 |
0.781 | 0.140 | -2 | 0.860 |
CDK7 |
0.781 | 0.024 | 1 | 0.730 |
PLK4 |
0.780 | -0.078 | 2 | 0.195 |
SRPK3 |
0.780 | 0.024 | -3 | 0.672 |
GRK1 |
0.780 | 0.010 | -2 | 0.726 |
PLK3 |
0.780 | 0.012 | 2 | 0.361 |
PKCE |
0.780 | 0.068 | 2 | 0.220 |
DLK |
0.780 | -0.119 | 1 | 0.839 |
GRK5 |
0.779 | -0.142 | -3 | 0.810 |
CDK2 |
0.779 | 0.040 | 1 | 0.773 |
MLK3 |
0.779 | -0.099 | 2 | 0.252 |
HIPK1 |
0.779 | 0.070 | 1 | 0.779 |
KIS |
0.778 | -0.005 | 1 | 0.749 |
DYRK3 |
0.778 | 0.117 | 1 | 0.779 |
TTBK2 |
0.778 | -0.177 | 2 | 0.216 |
PLK1 |
0.778 | -0.071 | -2 | 0.750 |
CDK18 |
0.777 | 0.036 | 1 | 0.677 |
IRAK4 |
0.777 | -0.032 | 1 | 0.816 |
CDK19 |
0.777 | 0.008 | 1 | 0.704 |
ERK7 |
0.776 | -0.021 | 2 | 0.189 |
P70S6K |
0.776 | 0.015 | -3 | 0.687 |
MAPKAPK5 |
0.776 | -0.016 | -3 | 0.691 |
DYRK4 |
0.775 | 0.084 | 1 | 0.689 |
WNK4 |
0.775 | -0.027 | -2 | 0.856 |
JNK2 |
0.775 | 0.047 | 1 | 0.687 |
CDK9 |
0.775 | 0.020 | 1 | 0.724 |
HIPK2 |
0.775 | 0.062 | 1 | 0.681 |
DYRK1B |
0.775 | 0.077 | 1 | 0.729 |
CDK1 |
0.774 | 0.046 | 1 | 0.696 |
CDK14 |
0.774 | 0.057 | 1 | 0.727 |
MEK1 |
0.774 | -0.115 | 2 | 0.318 |
CDK13 |
0.774 | 0.016 | 1 | 0.713 |
TGFBR1 |
0.774 | 0.012 | -2 | 0.717 |
HIPK3 |
0.774 | 0.042 | 1 | 0.781 |
MLK4 |
0.774 | -0.117 | 2 | 0.255 |
P38A |
0.773 | 0.025 | 1 | 0.764 |
AKT3 |
0.773 | 0.103 | -3 | 0.591 |
CDK10 |
0.773 | 0.066 | 1 | 0.711 |
DAPK3 |
0.773 | 0.160 | -3 | 0.774 |
DYRK1A |
0.773 | 0.031 | 1 | 0.787 |
PKN1 |
0.772 | 0.022 | -3 | 0.714 |
CAMK1A |
0.772 | 0.076 | -3 | 0.636 |
ALK4 |
0.772 | -0.067 | -2 | 0.751 |
VRK2 |
0.772 | -0.182 | 1 | 0.881 |
DRAK1 |
0.771 | -0.050 | 1 | 0.776 |
BMPR1B |
0.771 | 0.018 | 1 | 0.752 |
CDK17 |
0.771 | 0.030 | 1 | 0.626 |
SMG1 |
0.771 | -0.021 | 1 | 0.804 |
IRAK1 |
0.770 | -0.028 | -1 | 0.729 |
PKG1 |
0.770 | 0.125 | -2 | 0.805 |
ALK2 |
0.770 | 0.051 | -2 | 0.730 |
MRCKB |
0.770 | 0.126 | -3 | 0.727 |
GRK4 |
0.769 | -0.140 | -2 | 0.745 |
CDK12 |
0.769 | 0.020 | 1 | 0.691 |
JNK3 |
0.769 | 0.025 | 1 | 0.719 |
BRAF |
0.769 | -0.028 | -4 | 0.812 |
CDK16 |
0.769 | 0.044 | 1 | 0.645 |
PINK1 |
0.768 | -0.075 | 1 | 0.844 |
YSK4 |
0.768 | -0.155 | 1 | 0.793 |
ERK2 |
0.768 | -0.001 | 1 | 0.739 |
MST3 |
0.768 | -0.047 | 2 | 0.270 |
NEK5 |
0.768 | -0.084 | 1 | 0.850 |
MRCKA |
0.768 | 0.126 | -3 | 0.743 |
CDK3 |
0.768 | 0.070 | 1 | 0.641 |
SGK1 |
0.767 | 0.084 | -3 | 0.579 |
ROCK2 |
0.765 | 0.135 | -3 | 0.762 |
PERK |
0.764 | -0.162 | -2 | 0.773 |
ERK1 |
0.764 | -0.002 | 1 | 0.695 |
P38B |
0.764 | 0.026 | 1 | 0.699 |
DAPK1 |
0.764 | 0.131 | -3 | 0.755 |
P38G |
0.764 | 0.019 | 1 | 0.621 |
HRI |
0.764 | -0.156 | -2 | 0.797 |
CHK2 |
0.764 | 0.022 | -3 | 0.625 |
ZAK |
0.764 | -0.141 | 1 | 0.808 |
DMPK1 |
0.763 | 0.170 | -3 | 0.749 |
MEKK1 |
0.763 | -0.152 | 1 | 0.834 |
ACVR2A |
0.763 | -0.051 | -2 | 0.715 |
MEK5 |
0.763 | -0.181 | 2 | 0.291 |
MEKK3 |
0.762 | -0.144 | 1 | 0.821 |
PRP4 |
0.762 | -0.012 | -3 | 0.706 |
TTBK1 |
0.762 | -0.133 | 2 | 0.182 |
TAO3 |
0.761 | -0.052 | 1 | 0.814 |
GAK |
0.761 | 0.059 | 1 | 0.863 |
MEKK2 |
0.761 | -0.148 | 2 | 0.273 |
STK33 |
0.761 | -0.067 | 2 | 0.202 |
ACVR2B |
0.760 | -0.058 | -2 | 0.725 |
GRK7 |
0.760 | -0.031 | 1 | 0.786 |
CAMKK1 |
0.760 | -0.068 | -2 | 0.775 |
CDK6 |
0.759 | 0.028 | 1 | 0.707 |
LKB1 |
0.759 | -0.029 | -3 | 0.818 |
MPSK1 |
0.758 | -0.015 | 1 | 0.808 |
TAO2 |
0.758 | -0.064 | 2 | 0.296 |
SBK |
0.758 | 0.054 | -3 | 0.556 |
LOK |
0.758 | -0.023 | -2 | 0.818 |
NEK8 |
0.758 | -0.117 | 2 | 0.261 |
ROCK1 |
0.758 | 0.128 | -3 | 0.742 |
TLK2 |
0.758 | -0.157 | 1 | 0.814 |
NEK11 |
0.758 | -0.125 | 1 | 0.828 |
NEK4 |
0.757 | -0.081 | 1 | 0.813 |
PASK |
0.756 | -0.012 | -3 | 0.787 |
BMPR1A |
0.756 | 0.008 | 1 | 0.727 |
MEKK6 |
0.756 | -0.094 | 1 | 0.817 |
TLK1 |
0.756 | -0.142 | -2 | 0.740 |
PDK1 |
0.756 | -0.045 | 1 | 0.833 |
CAMKK2 |
0.755 | -0.059 | -2 | 0.788 |
CDK4 |
0.755 | 0.030 | 1 | 0.677 |
TNIK |
0.755 | -0.007 | 3 | 0.853 |
GRK2 |
0.755 | -0.077 | -2 | 0.653 |
CK1E |
0.754 | -0.054 | -3 | 0.528 |
P38D |
0.754 | 0.021 | 1 | 0.636 |
MOK |
0.754 | 0.045 | 1 | 0.784 |
MAK |
0.754 | 0.059 | -2 | 0.744 |
HGK |
0.753 | -0.041 | 3 | 0.844 |
HPK1 |
0.753 | -0.007 | 1 | 0.810 |
MINK |
0.753 | -0.023 | 1 | 0.814 |
GCK |
0.752 | -0.029 | 1 | 0.817 |
MAP3K15 |
0.752 | -0.100 | 1 | 0.801 |
KHS2 |
0.752 | 0.029 | 1 | 0.815 |
PLK2 |
0.752 | -0.002 | -3 | 0.754 |
NEK1 |
0.752 | -0.059 | 1 | 0.822 |
KHS1 |
0.751 | 0.004 | 1 | 0.806 |
LRRK2 |
0.750 | -0.089 | 2 | 0.289 |
EEF2K |
0.750 | -0.089 | 3 | 0.834 |
SLK |
0.750 | -0.033 | -2 | 0.736 |
PBK |
0.748 | 0.032 | 1 | 0.788 |
MST2 |
0.748 | -0.118 | 1 | 0.822 |
NEK3 |
0.748 | -0.086 | 1 | 0.796 |
BUB1 |
0.748 | 0.025 | -5 | 0.817 |
YANK3 |
0.746 | -0.042 | 2 | 0.166 |
CRIK |
0.746 | 0.065 | -3 | 0.666 |
YSK1 |
0.746 | -0.088 | 2 | 0.253 |
CK1A2 |
0.745 | -0.040 | -3 | 0.484 |
MST1 |
0.745 | -0.101 | 1 | 0.807 |
CK1D |
0.745 | -0.039 | -3 | 0.481 |
RIPK2 |
0.745 | -0.127 | 1 | 0.768 |
CK1G1 |
0.744 | -0.086 | -3 | 0.508 |
VRK1 |
0.743 | -0.157 | 2 | 0.282 |
JNK1 |
0.743 | 0.005 | 1 | 0.671 |
TAK1 |
0.742 | -0.143 | 1 | 0.829 |
MEK2 |
0.741 | -0.165 | 2 | 0.277 |
BIKE |
0.741 | 0.072 | 1 | 0.767 |
CK2A2 |
0.739 | 0.027 | 1 | 0.604 |
HASPIN |
0.739 | 0.003 | -1 | 0.737 |
GRK3 |
0.737 | -0.082 | -2 | 0.603 |
GSK3B |
0.737 | -0.066 | 4 | 0.304 |
PDHK3_TYR |
0.736 | 0.045 | 4 | 0.874 |
GSK3A |
0.734 | -0.051 | 4 | 0.315 |
MYO3B |
0.734 | -0.057 | 2 | 0.263 |
TESK1_TYR |
0.733 | 0.013 | 3 | 0.857 |
LIMK2_TYR |
0.732 | 0.025 | -3 | 0.861 |
TAO1 |
0.731 | -0.083 | 1 | 0.760 |
TTK |
0.730 | -0.085 | -2 | 0.755 |
MAP2K7_TYR |
0.729 | -0.072 | 2 | 0.335 |
MYO3A |
0.729 | -0.081 | 1 | 0.801 |
CK2A1 |
0.729 | 0.018 | 1 | 0.581 |
ASK1 |
0.729 | -0.108 | 1 | 0.789 |
PDHK4_TYR |
0.728 | 0.020 | 2 | 0.372 |
EPHA6 |
0.728 | 0.037 | -1 | 0.795 |
PKMYT1_TYR |
0.727 | -0.072 | 3 | 0.812 |
OSR1 |
0.727 | -0.141 | 2 | 0.271 |
PINK1_TYR |
0.726 | -0.086 | 1 | 0.840 |
BMPR2_TYR |
0.726 | 0.018 | -1 | 0.813 |
RET |
0.726 | -0.019 | 1 | 0.831 |
AAK1 |
0.725 | 0.082 | 1 | 0.676 |
MAP2K6_TYR |
0.725 | -0.019 | -1 | 0.827 |
ALPHAK3 |
0.724 | 0.029 | -1 | 0.727 |
LIMK1_TYR |
0.724 | -0.071 | 2 | 0.313 |
MAP2K4_TYR |
0.723 | -0.111 | -1 | 0.820 |
DDR1 |
0.722 | 0.033 | 4 | 0.823 |
TYK2 |
0.722 | -0.106 | 1 | 0.831 |
MST1R |
0.721 | -0.083 | 3 | 0.788 |
PDHK1_TYR |
0.721 | -0.062 | -1 | 0.847 |
TYRO3 |
0.719 | -0.094 | 3 | 0.795 |
ROS1 |
0.719 | -0.119 | 3 | 0.774 |
TNK1 |
0.717 | -0.031 | 3 | 0.760 |
EPHB4 |
0.717 | -0.039 | -1 | 0.769 |
JAK3 |
0.717 | -0.064 | 1 | 0.813 |
JAK2 |
0.717 | -0.107 | 1 | 0.829 |
FGFR2 |
0.716 | 0.002 | 3 | 0.770 |
TNNI3K_TYR |
0.716 | -0.061 | 1 | 0.810 |
CSF1R |
0.715 | -0.081 | 3 | 0.779 |
INSRR |
0.715 | 0.010 | 3 | 0.747 |
NEK10_TYR |
0.715 | -0.060 | 1 | 0.728 |
YES1 |
0.715 | -0.000 | -1 | 0.795 |
EPHA4 |
0.715 | 0.011 | 2 | 0.374 |
STLK3 |
0.714 | -0.179 | 1 | 0.771 |
PDGFRB |
0.713 | -0.084 | 3 | 0.795 |
TEK |
0.713 | -0.055 | 3 | 0.733 |
ABL2 |
0.712 | -0.034 | -1 | 0.751 |
TNK2 |
0.711 | -0.051 | 3 | 0.737 |
FGFR1 |
0.711 | -0.061 | 3 | 0.759 |
YANK2 |
0.711 | -0.062 | 2 | 0.193 |
FLT3 |
0.710 | -0.084 | 3 | 0.778 |
AXL |
0.709 | -0.057 | 3 | 0.768 |
DDR2 |
0.708 | 0.070 | 3 | 0.727 |
KDR |
0.708 | -0.089 | 3 | 0.744 |
HCK |
0.708 | -0.043 | -1 | 0.757 |
EPHB2 |
0.708 | -0.022 | -1 | 0.749 |
ITK |
0.707 | -0.073 | -1 | 0.726 |
KIT |
0.707 | -0.077 | 3 | 0.775 |
JAK1 |
0.707 | -0.110 | 1 | 0.787 |
EPHB3 |
0.707 | -0.049 | -1 | 0.745 |
SRMS |
0.707 | -0.012 | 1 | 0.819 |
LCK |
0.706 | -0.024 | -1 | 0.763 |
FER |
0.706 | -0.072 | 1 | 0.836 |
ABL1 |
0.706 | -0.076 | -1 | 0.744 |
PDGFRA |
0.706 | -0.149 | 3 | 0.794 |
FGR |
0.705 | -0.105 | 1 | 0.841 |
EPHB1 |
0.705 | -0.077 | 1 | 0.826 |
BLK |
0.704 | -0.011 | -1 | 0.778 |
EPHA7 |
0.704 | -0.017 | 2 | 0.354 |
ALK |
0.703 | -0.103 | 3 | 0.714 |
WEE1_TYR |
0.703 | -0.084 | -1 | 0.700 |
FGFR3 |
0.703 | -0.045 | 3 | 0.748 |
LTK |
0.703 | -0.072 | 3 | 0.721 |
EPHA3 |
0.703 | -0.051 | 2 | 0.341 |
CK1A |
0.703 | -0.088 | -3 | 0.392 |
EPHA1 |
0.703 | -0.049 | 3 | 0.749 |
TXK |
0.703 | -0.052 | 1 | 0.773 |
INSR |
0.702 | -0.054 | 3 | 0.719 |
MERTK |
0.702 | -0.079 | 3 | 0.758 |
EPHA5 |
0.699 | 0.018 | 2 | 0.389 |
MET |
0.699 | -0.117 | 3 | 0.764 |
TEC |
0.698 | -0.094 | -1 | 0.671 |
BTK |
0.698 | -0.111 | -1 | 0.686 |
BMX |
0.698 | -0.059 | -1 | 0.654 |
NTRK1 |
0.698 | -0.098 | -1 | 0.742 |
FLT4 |
0.697 | -0.119 | 3 | 0.726 |
ERBB2 |
0.697 | -0.096 | 1 | 0.785 |
FYN |
0.697 | 0.006 | -1 | 0.741 |
NTRK2 |
0.695 | -0.139 | 3 | 0.743 |
PTK2B |
0.695 | -0.057 | -1 | 0.724 |
LYN |
0.695 | -0.034 | 3 | 0.687 |
FLT1 |
0.692 | -0.123 | -1 | 0.758 |
EPHA8 |
0.692 | -0.044 | -1 | 0.732 |
EGFR |
0.692 | -0.024 | 1 | 0.704 |
FRK |
0.691 | -0.136 | -1 | 0.768 |
MATK |
0.691 | -0.100 | -1 | 0.704 |
PTK2 |
0.689 | -0.019 | -1 | 0.711 |
PTK6 |
0.689 | -0.218 | -1 | 0.648 |
SRC |
0.688 | -0.052 | -1 | 0.744 |
FGFR4 |
0.688 | -0.042 | -1 | 0.704 |
NTRK3 |
0.687 | -0.112 | -1 | 0.690 |
CSK |
0.686 | -0.100 | 2 | 0.332 |
CK1G3 |
0.686 | -0.070 | -3 | 0.345 |
EPHA2 |
0.685 | -0.033 | -1 | 0.689 |
IGF1R |
0.684 | -0.072 | 3 | 0.655 |
MUSK |
0.679 | -0.144 | 1 | 0.710 |
ERBB4 |
0.678 | -0.030 | 1 | 0.709 |
SYK |
0.674 | -0.046 | -1 | 0.693 |
FES |
0.665 | -0.123 | -1 | 0.633 |
CK1G2 |
0.660 | -0.081 | -3 | 0.435 |
ZAP70 |
0.649 | -0.087 | -1 | 0.638 |