Motif 590 (n=195)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NC98 | CCDC88B | S1444 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| O00124 | UBXN8 | S144 | ochoa | UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) | Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}. |
| O00329 | PIK3CD | S520 | ochoa | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. {ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:20081091, ECO:0000269|PubMed:22020336, ECO:0000269|PubMed:9235916}. |
| O14639 | ABLIM1 | S540 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14686 | KMT2D | S4814 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15164 | TRIM24 | S209 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O43295 | SRGAP3 | S954 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43683 | BUB1 | S314 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43765 | SGTA | S88 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| O60353 | FZD6 | S629 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O60502 | OGA | S511 | ochoa | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714, ECO:0000269|PubMed:28939839, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}. |
| O60566 | BUB1B | S569 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75152 | ZC3H11A | S768 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75459 | PAGE1 | S105 | ochoa | P antigen family member 1 (PAGE-1) (AL5) (G antigen 9) (GAGE-9) (G antigen family B member 1) (Prostate-associated gene 1 protein) | None |
| O75791 | GRAP2 | S41 | ochoa | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| O94864 | SUPT7L | S328 | ochoa | STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) | None |
| O94985 | CLSTN1 | S436 | ochoa | Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9EPL2, ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:21385839}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding (PubMed:15037614). {ECO:0000305|PubMed:15037614}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614). {ECO:0000305|PubMed:15037614}. |
| O95453 | PARN | S572 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O96028 | NSD2 | S408 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P02766 | TTR | S72 | ochoa | Transthyretin (ATTR) (Prealbumin) (TBPA) | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. {ECO:0000269|PubMed:3714052}. |
| P02810 | PRH1; | S24 | psp | Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C] | PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth. |
| P03956 | MMP1 | S382 | ochoa | Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}. |
| P04792 | HSPB1 | S158 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05060 | CHGB | S617 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P08047 | SP1 | S670 | ochoa|psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08134 | RHOC | S152 | ochoa | Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) | Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}. |
| P0DPH7 | TUBA3C | S277 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S277 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11277 | SPTB | S2043 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P12111 | COL6A3 | S162 | ochoa | Collagen alpha-3(VI) chain | Collagen VI acts as a cell-binding protein. |
| P13611 | VCAN | S2116 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P14317 | HCLS1 | S320 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P17181 | IFNAR1 | S495 | ochoa | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}. |
| P17480 | UBTF | S579 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P17661 | DES | S432 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P23327 | HRC | S333 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P23560 | BDNF | T62 | psp | Neurotrophic factor BDNF precursor form (proBDNF) (Abrineurin) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF] | Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:12553913, ECO:0000269|PubMed:29909994}.; FUNCTION: [Neurotrophic factor BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {ECO:0000250|UniProtKB:P21237, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:29909994}. |
| P23634 | ATP2B4 | S328 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P24821 | TNC | S616 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P28290 | ITPRID2 | S1175 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29590 | PML | S403 | ochoa|psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30414 | NKTR | S379 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P31629 | HIVEP2 | S1089 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P31947 | SFN | S69 | psp | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P33241 | LSP1 | S141 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P38398 | BRCA1 | S425 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40855 | PEX19 | S66 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| P42566 | EPS15 | S563 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46013 | MKI67 | S1115 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1546 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49755 | TMED10 | S86 | ochoa | Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999). {ECO:0000250|UniProtKB:Q28735, ECO:0000250|UniProtKB:Q63584, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:27569046, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:10052452}. |
| P50542 | PEX5 | S141 | psp | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}. |
| P50591 | TNFSF10 | S96 | ochoa | Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. |
| P50851 | LRBA | S1086 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51797 | CLCN6 | S683 | ochoa | H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6) | Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. {ECO:0000269|PubMed:20466723}. |
| P63104 | YWHAZ | S64 | ochoa|psp | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68363 | TUBA1B | S277 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S277 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78559 | MAP1A | S1200 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98171 | ARHGAP4 | S842 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00987 | MDM2 | S407 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02410 | APBA1 | S248 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q02446 | SP4 | S691 | ochoa | Transcription factor Sp4 (SPR-1) | Binds to GT and GC boxes promoters elements. Probable transcriptional activator. |
| Q02447 | SP3 | S665 | ochoa | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q02790 | FKBP4 | S263 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q0VF96 | CGNL1 | S476 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12888 | TP53BP1 | S786 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1202 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12955 | ANK3 | S2445 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13426 | XRCC4 | S315 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13469 | NFATC2 | S118 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13546 | RIPK1 | S262 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13813 | SPTAN1 | S1479 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14151 | SAFB2 | S513 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14157 | UBAP2L | S95 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14160 | SCRIB | S515 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14160 | SCRIB | S1232 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14247 | CTTN | S447 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14766 | LTBP1 | S787 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14980 | NUMA1 | S934 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14D04 | VEPH1 | S380 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15139 | PRKD1 | S473 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15477 | SKIC2 | S256 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q15596 | NCOA2 | S1074 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16790 | CA9 | S67 | ochoa | Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) | Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}. |
| Q2NKX8 | ERCC6L | S1181 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q32MZ4 | LRRFIP1 | S491 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q59EK9 | RUNDC3A | S374 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5T5P2 | KIAA1217 | S1259 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T8I3 | EEIG2 | S288 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5T9C2 | EEIG1 | S311 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5TC84 | OGFRL1 | S381 | ochoa | Opioid growth factor receptor-like protein 1 | None |
| Q5TCY1 | TTBK1 | S540 | ochoa | Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) | Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}. |
| Q5VST9 | OBSCN | S5669 | psp | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VVJ2 | MYSM1 | S267 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q68CZ2 | TNS3 | S972 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6IBS0 | TWF2 | S149 | ochoa | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
| Q6IBW4 | NCAPH2 | S246 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6P0Q8 | MAST2 | S1717 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P1L5 | FAM117B | S345 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6PEY2 | TUBA3E | S277 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6ZMW3 | EML6 | S1281 | ochoa | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}. |
| Q70SY1 | CREB3L2 | S290 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q71U36 | TUBA1A | S277 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z591 | AKNA | S174 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z7B0 | FILIP1 | S1082 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86T90 | KIAA1328 | S65 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86UU1 | PHLDB1 | S682 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UW6 | N4BP2 | S600 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86VS8 | HOOK3 | S232 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86W50 | METTL16 | S450 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86W50 | METTL16 | S455 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IUD2 | ERC1 | S730 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IWQ3 | BRSK2 | S382 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
| Q8IY37 | DHX37 | S510 | ochoa | Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) | ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably also plays a role in brain development (PubMed:31256877). {ECO:0000269|PubMed:30582406, ECO:0000269|PubMed:31256877, ECO:0000269|PubMed:31287541, ECO:0000269|PubMed:31337883, ECO:0000269|PubMed:34516797}. |
| Q8N201 | INTS1 | S307 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N292 | GAPT | S74 | ochoa | Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane) | Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}. |
| Q8N392 | ARHGAP18 | S74 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N4S0 | CCDC82 | S154 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8N4X5 | AFAP1L2 | S651 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N573 | OXR1 | S367 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5Y2 | MSL3 | S407 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N7H5 | PAF1 | S147 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
| Q8NCN4 | RNF169 | S472 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NDX1 | PSD4 | S24 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFC6 | BOD1L1 | S2844 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TAD8 | SNIP1 | S202 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TAP9 | MPLKIP | S133 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8WXD9 | CASKIN1 | S706 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q92530 | PSMF1 | S127 | ochoa | Proteasome inhibitor PI31 subunit (hPI31) | Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}. |
| Q92541 | RTF1 | S60 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92574 | TSC1 | S468 | ochoa|psp | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92575 | UBXN4 | S180 | ochoa | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}. |
| Q92858 | ATOH1 | S84 | ochoa | Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1) | Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P48985}. |
| Q92974 | ARHGEF2 | S186 | psp | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96CX6 | LRRC58 | S24 | ochoa | Leucine-rich repeat-containing protein 58 | None |
| Q96DX7 | TRIM44 | S320 | ochoa | Tripartite motif-containing protein 44 (Protein DIPB) | May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}. |
| Q96FI4 | NEIL1 | S207 | ochoa|psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
| Q96GE4 | CEP95 | S217 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96JH8 | RADIL | S540 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96JM7 | L3MBTL3 | S625 | ochoa | Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96JZ2 | HSH2D | S319 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96L93 | KIF16B | S1104 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96PU8 | QKI | S64 | ochoa | KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:22398723, PubMed:23630077, PubMed:25768908, PubMed:27029405, PubMed:31331967, PubMed:37379838). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:25768908, PubMed:31829086, PubMed:34428287, PubMed:37379838). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:23630077). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:25768908). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:25768908). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:16641098). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:27029405). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (PubMed:31331967). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:23630077, ECO:0000269|PubMed:25768908, ECO:0000269|PubMed:27029405, ECO:0000269|PubMed:31331967, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (PubMed:31829086). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (PubMed:34428287). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (PubMed:22398723). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287}.; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (PubMed:31792053). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:31792053, ECO:0000269|PubMed:32732889, ECO:0000269|PubMed:37379838}. |
| Q96R06 | SPAG5 | S79 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RT1 | ERBIN | S598 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RU3 | FNBP1 | S527 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q96SN8 | CDK5RAP2 | S697 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99684 | GFI1 | S56 | ochoa | Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) | Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}. |
| Q9BQE3 | TUBA1C | S277 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BQF6 | SENP7 | S436 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BTC0 | DIDO1 | S114 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVS4 | RIOK2 | S382 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BXL5 | HEMGN | S381 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BXW9 | FANCD2 | S886 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9C0C2 | TNKS1BP1 | S221 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0G0 | ZNF407 | S356 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9C0H5 | ARHGAP39 | S644 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H0E9 | BRD8 | S641 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H2J7 | SLC6A15 | S25 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H2P0 | ADNP | S923 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H981 | ACTR8 | S468 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9H9A7 | RMI1 | S225 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HBR0 | SLC38A10 | S997 | ochoa | Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) | Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}. |
| Q9NQB0 | TCF7L2 | S31 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NRL2 | BAZ1A | S714 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NS25 | SPANXB1 | S69 | ochoa | Sperm protein associated with the nucleus on the X chromosome B1 (Cancer/testis antigen 11.2) (CT11.2) (Nuclear-associated protein SPAN-Xb) (SPANX-B) (SPANX family member B1) (SPANX family member F1) | None |
| Q9NS26 | SPANXA1 | S63 | ochoa | Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A) | None |
| Q9NSK0 | KLC4 | S163 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NVI1 | FANCI | S1111 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NWZ3 | IRAK4 | S152 | ochoa|psp | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9NXL9 | MCM9 | S1109 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NYD6 | HOXC10 | S115 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NYQ6 | CELSR1 | S2889 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9P242 | NYAP2 | S154 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P2D1 | CHD7 | S2159 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2R6 | RERE | S479 | psp | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9P2W9 | STX18 | S194 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UIG0 | BAZ1B | S98 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKS7 | IKZF2 | S375 | ochoa | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}. |
| Q9UKV3 | ACIN1 | S714 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S865 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULI0 | ATAD2B | S1321 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UPU7 | TBC1D2B | S181 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y3E2 | BOLA1 | S45 | ochoa | BolA-like protein 1 (hBolA) | Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225). {ECO:0000250|UniProtKB:Q3E793, ECO:0000269|PubMed:22746225, ECO:0000305|PubMed:27532772}. |
| Q9Y3R5 | DOP1B | S1050 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y520 | PRRC2C | S848 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5U5 | TNFRSF18 | S211 | ochoa | Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Q13409 | DYNC1I2 | S219 | Sugiyama | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
| P23396 | RPS3 | S83 | Sugiyama | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| Q9Y639 | NPTN | S213 | Sugiyama | Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). {ECO:0000250|UniProtKB:P97546, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:30190470}. |
| P09132 | SRP19 | S69 | Sugiyama | Signal recognition particle 19 kDa protein (SRP19) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity). {ECO:0000250|UniProtKB:J9PAS6}. |
| P50542 | PEX5 | S167 | Sugiyama | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}. |
| P48444 | ARCN1 | S138 | Sugiyama | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| Q9BQI3 | EIF2AK1 | S253 | Sugiyama | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.483944e-09 | 8.458 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.347902e-08 | 7.475 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.731181e-08 | 7.564 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.686115e-08 | 7.433 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.025255e-08 | 7.519 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 6.459823e-08 | 7.190 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.463118e-07 | 6.835 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.187346e-07 | 6.660 |
| R-HSA-9646399 | Aggrephagy | 3.168292e-07 | 6.499 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.930407e-07 | 6.307 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.020833e-07 | 6.299 |
| R-HSA-983189 | Kinesins | 4.639696e-07 | 6.334 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.772203e-07 | 6.057 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.006393e-06 | 5.997 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 9.726850e-07 | 6.012 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.151426e-06 | 5.939 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.239751e-06 | 5.907 |
| R-HSA-190861 | Gap junction assembly | 1.720115e-06 | 5.764 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.928833e-06 | 5.715 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.756536e-06 | 5.560 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.750469e-06 | 5.561 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.122061e-06 | 5.506 |
| R-HSA-68877 | Mitotic Prometaphase | 7.405788e-06 | 5.130 |
| R-HSA-190828 | Gap junction trafficking | 8.020118e-06 | 5.096 |
| R-HSA-9663891 | Selective autophagy | 8.128202e-06 | 5.090 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.041114e-05 | 4.983 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.148174e-05 | 4.940 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.144692e-05 | 4.941 |
| R-HSA-437239 | Recycling pathway of L1 | 1.148174e-05 | 4.940 |
| R-HSA-373760 | L1CAM interactions | 1.284634e-05 | 4.891 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.441465e-05 | 4.841 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.672908e-05 | 4.573 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.272493e-05 | 4.369 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.167776e-05 | 4.287 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.245812e-05 | 4.280 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.490543e-05 | 4.260 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.490543e-05 | 4.260 |
| R-HSA-1632852 | Macroautophagy | 6.540441e-05 | 4.184 |
| R-HSA-391251 | Protein folding | 8.329815e-05 | 4.079 |
| R-HSA-199991 | Membrane Trafficking | 1.123416e-04 | 3.949 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.105587e-04 | 3.956 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.149016e-04 | 3.940 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.155561e-04 | 3.937 |
| R-HSA-5620924 | Intraflagellar transport | 1.248079e-04 | 3.904 |
| R-HSA-9612973 | Autophagy | 1.427190e-04 | 3.846 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.126779e-04 | 3.672 |
| R-HSA-9833482 | PKR-mediated signaling | 2.126779e-04 | 3.672 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.459776e-04 | 3.461 |
| R-HSA-1640170 | Cell Cycle | 3.675508e-04 | 3.435 |
| R-HSA-68882 | Mitotic Anaphase | 3.987033e-04 | 3.399 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.128905e-04 | 3.384 |
| R-HSA-422475 | Axon guidance | 7.025970e-04 | 3.153 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.236506e-04 | 3.034 |
| R-HSA-68886 | M Phase | 1.219979e-03 | 2.914 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.488697e-03 | 2.827 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.402408e-03 | 2.853 |
| R-HSA-9675108 | Nervous system development | 1.423792e-03 | 2.847 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.372665e-03 | 2.862 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.647876e-03 | 2.783 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.920901e-03 | 2.716 |
| R-HSA-69275 | G2/M Transition | 1.989878e-03 | 2.701 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.255895e-03 | 2.647 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.122797e-03 | 2.673 |
| R-HSA-5617833 | Cilium Assembly | 2.262706e-03 | 2.645 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.415419e-03 | 2.617 |
| R-HSA-9609690 | HCMV Early Events | 2.726974e-03 | 2.564 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.136110e-03 | 2.383 |
| R-HSA-8852135 | Protein ubiquitination | 5.554967e-03 | 2.255 |
| R-HSA-597592 | Post-translational protein modification | 5.882458e-03 | 2.230 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.120408e-03 | 2.147 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.200757e-03 | 2.143 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.794373e-03 | 2.108 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.326446e-03 | 2.135 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.101027e-03 | 2.041 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 9.107108e-03 | 2.041 |
| R-HSA-3371378 | Regulation by c-FLIP | 9.834635e-03 | 2.007 |
| R-HSA-69416 | Dimerization of procaspase-8 | 9.834635e-03 | 2.007 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 9.834635e-03 | 2.007 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.160206e-02 | 1.935 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.160206e-02 | 1.935 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.031039e-02 | 1.987 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.160206e-02 | 1.935 |
| R-HSA-9609646 | HCMV Infection | 1.137589e-02 | 1.944 |
| R-HSA-69481 | G2/M Checkpoints | 1.294242e-02 | 1.888 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.318004e-02 | 1.880 |
| R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 1.332450e-02 | 1.875 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.349781e-02 | 1.870 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.551818e-02 | 1.809 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.595486e-02 | 1.797 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.595486e-02 | 1.797 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.825958e-02 | 1.739 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.646853e-02 | 1.783 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.739252e-02 | 1.760 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.765955e-02 | 1.753 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.902226e-02 | 1.721 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.907134e-02 | 1.720 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.197213e-02 | 1.658 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.227063e-02 | 1.652 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.229115e-02 | 1.652 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.440935e-02 | 1.612 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.477449e-02 | 1.606 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.647227e-02 | 1.577 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.647227e-02 | 1.577 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 3.005954e-02 | 1.522 |
| R-HSA-380287 | Centrosome maturation | 2.636975e-02 | 1.579 |
| R-HSA-3371568 | Attenuation phase | 2.601741e-02 | 1.585 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 3.005954e-02 | 1.522 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.887149e-02 | 1.540 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.736504e-02 | 1.563 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.005954e-02 | 1.522 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.736504e-02 | 1.563 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.948292e-02 | 1.530 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.803499e-02 | 1.552 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.280497e-02 | 1.484 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.285479e-02 | 1.483 |
| R-HSA-9675151 | Disorders of Developmental Biology | 3.285479e-02 | 1.483 |
| R-HSA-73894 | DNA Repair | 3.368339e-02 | 1.473 |
| R-HSA-109581 | Apoptosis | 3.566332e-02 | 1.448 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.633743e-02 | 1.440 |
| R-HSA-9675135 | Diseases of DNA repair | 3.689666e-02 | 1.433 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.873504e-02 | 1.412 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.880978e-02 | 1.411 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.880978e-02 | 1.411 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 3.944564e-02 | 1.404 |
| R-HSA-2262752 | Cellular responses to stress | 4.062871e-02 | 1.391 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.224691e-02 | 1.282 |
| R-HSA-9024909 | BDNF activates NTRK2 (TRKB) signaling | 5.224691e-02 | 1.282 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.224691e-02 | 1.282 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.224691e-02 | 1.282 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.224691e-02 | 1.282 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.224691e-02 | 1.282 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.224691e-02 | 1.282 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.224691e-02 | 1.282 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.224691e-02 | 1.282 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.224691e-02 | 1.282 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.224691e-02 | 1.282 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.224691e-02 | 1.282 |
| R-HSA-9918449 | Defective visual phototransduction due to STRA6 loss of function | 5.224691e-02 | 1.282 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 4.181397e-02 | 1.379 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.498148e-02 | 1.347 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.498148e-02 | 1.347 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.498148e-02 | 1.347 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.498148e-02 | 1.347 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.540226e-02 | 1.343 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.587967e-02 | 1.338 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.498148e-02 | 1.347 |
| R-HSA-913531 | Interferon Signaling | 4.746305e-02 | 1.324 |
| R-HSA-162582 | Signal Transduction | 5.056373e-02 | 1.296 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.794488e-02 | 1.237 |
| R-HSA-209563 | Axonal growth stimulation | 6.487836e-02 | 1.188 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.487836e-02 | 1.188 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 6.487836e-02 | 1.188 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.487836e-02 | 1.188 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 7.734223e-02 | 1.112 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 7.734223e-02 | 1.112 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 6.568953e-02 | 1.183 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.609650e-02 | 1.119 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.360948e-02 | 1.196 |
| R-HSA-9033241 | Peroxisomal protein import | 6.226744e-02 | 1.206 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 7.734223e-02 | 1.112 |
| R-HSA-8875513 | MET interacts with TNS proteins | 6.487836e-02 | 1.188 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 6.487836e-02 | 1.188 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 7.734223e-02 | 1.112 |
| R-HSA-429947 | Deadenylation of mRNA | 6.204898e-02 | 1.207 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 6.939972e-02 | 1.159 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 6.568953e-02 | 1.183 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.902341e-02 | 1.161 |
| R-HSA-5689901 | Metalloprotease DUBs | 6.939972e-02 | 1.159 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.226744e-02 | 1.206 |
| R-HSA-3214847 | HATs acetylate histones | 6.196503e-02 | 1.208 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.902341e-02 | 1.161 |
| R-HSA-392499 | Metabolism of proteins | 6.964372e-02 | 1.157 |
| R-HSA-112316 | Neuronal System | 6.715248e-02 | 1.173 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.721603e-02 | 1.173 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.969272e-02 | 1.099 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 8.092353e-02 | 1.092 |
| R-HSA-9609507 | Protein localization | 8.195826e-02 | 1.086 |
| R-HSA-74160 | Gene expression (Transcription) | 8.292308e-02 | 1.081 |
| R-HSA-73887 | Death Receptor Signaling | 8.351837e-02 | 1.078 |
| R-HSA-5357801 | Programmed Cell Death | 8.432576e-02 | 1.074 |
| R-HSA-114452 | Activation of BH3-only proteins | 8.488796e-02 | 1.071 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 8.964074e-02 | 1.047 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 8.964074e-02 | 1.047 |
| R-HSA-174577 | Activation of C3 and C5 | 8.964074e-02 | 1.047 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.095160e-02 | 1.041 |
| R-HSA-3000178 | ECM proteoglycans | 9.114863e-02 | 1.040 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 1.017761e-01 | 0.992 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 1.137503e-01 | 0.944 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 1.137503e-01 | 0.944 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.255657e-01 | 0.901 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.255657e-01 | 0.901 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.255657e-01 | 0.901 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.255657e-01 | 0.901 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.255657e-01 | 0.901 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.372243e-01 | 0.863 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.372243e-01 | 0.863 |
| R-HSA-75158 | TRAIL signaling | 1.017761e-01 | 0.992 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.055325e-01 | 0.977 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.141346e-01 | 0.943 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.013011e-01 | 0.994 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.229094e-01 | 0.910 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 9.711889e-02 | 1.013 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 9.711889e-02 | 1.013 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.273568e-01 | 0.895 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 9.711889e-02 | 1.013 |
| R-HSA-5693538 | Homology Directed Repair | 1.032326e-01 | 0.986 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 1.017761e-01 | 0.992 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.372243e-01 | 0.863 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.372243e-01 | 0.863 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.055325e-01 | 0.977 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.255657e-01 | 0.901 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.229094e-01 | 0.910 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.363625e-01 | 0.865 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.320659e-02 | 1.031 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.098110e-01 | 0.959 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 1.017761e-01 | 0.992 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.098110e-01 | 0.959 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.255657e-01 | 0.901 |
| R-HSA-4086400 | PCP/CE pathway | 1.101271e-01 | 0.958 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 9.711889e-02 | 1.013 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.055325e-01 | 0.977 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.185014e-01 | 0.926 |
| R-HSA-8874211 | CREB3 factors activate genes | 1.137503e-01 | 0.944 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 9.376961e-02 | 1.028 |
| R-HSA-3371511 | HSF1 activation | 1.141346e-01 | 0.943 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.287401e-01 | 0.890 |
| R-HSA-4791275 | Signaling by WNT in cancer | 9.298784e-02 | 1.032 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.304777e-01 | 0.884 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.098110e-01 | 0.959 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.365208e-01 | 0.865 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.273568e-01 | 0.895 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 9.298784e-02 | 1.032 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.216910e-01 | 0.915 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.409173e-01 | 0.851 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.455045e-01 | 0.837 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.487282e-01 | 0.828 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.487282e-01 | 0.828 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.487282e-01 | 0.828 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.487282e-01 | 0.828 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.487282e-01 | 0.828 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.487282e-01 | 0.828 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.487282e-01 | 0.828 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.487282e-01 | 0.828 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.515924e-01 | 0.819 |
| R-HSA-4839726 | Chromatin organization | 1.553945e-01 | 0.809 |
| R-HSA-212436 | Generic Transcription Pathway | 1.563926e-01 | 0.806 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.712799e-01 | 0.766 |
| R-HSA-2022923 | DS-GAG biosynthesis | 1.823317e-01 | 0.739 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.823317e-01 | 0.739 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.932368e-01 | 0.714 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.250911e-01 | 0.648 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.250911e-01 | 0.648 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.456286e-01 | 0.610 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.456286e-01 | 0.610 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.456286e-01 | 0.610 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.556933e-01 | 0.592 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.754234e-01 | 0.560 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.946328e-01 | 0.531 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.946328e-01 | 0.531 |
| R-HSA-2022870 | CS-GAG biosynthesis | 3.040466e-01 | 0.517 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.040466e-01 | 0.517 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.040466e-01 | 0.517 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.040466e-01 | 0.517 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.220570e-01 | 0.654 |
| R-HSA-9664873 | Pexophagy | 1.600794e-01 | 0.796 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.133353e-01 | 0.504 |
| R-HSA-4641265 | Repression of WNT target genes | 1.932368e-01 | 0.714 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.850923e-01 | 0.545 |
| R-HSA-164843 | 2-LTR circle formation | 1.600794e-01 | 0.796 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.456286e-01 | 0.610 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.594438e-01 | 0.797 |
| R-HSA-1221632 | Meiotic synapsis | 1.976510e-01 | 0.704 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.505221e-01 | 0.601 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.456286e-01 | 0.610 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.664616e-01 | 0.574 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.932368e-01 | 0.714 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.600794e-01 | 0.796 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.932368e-01 | 0.714 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.250911e-01 | 0.648 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.250911e-01 | 0.648 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.556933e-01 | 0.592 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.928094e-01 | 0.715 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.976510e-01 | 0.704 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.466861e-01 | 0.608 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.754234e-01 | 0.560 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.133353e-01 | 0.504 |
| R-HSA-9766229 | Degradation of CDH1 | 1.783862e-01 | 0.749 |
| R-HSA-5218859 | Regulated Necrosis | 2.714075e-01 | 0.566 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.010339e-01 | 0.521 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.823317e-01 | 0.739 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.754234e-01 | 0.560 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.876069e-01 | 0.541 |
| R-HSA-392517 | Rap1 signalling | 2.754234e-01 | 0.560 |
| R-HSA-3371556 | Cellular response to heat stress | 2.720685e-01 | 0.565 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.656243e-01 | 0.576 |
| R-HSA-1442490 | Collagen degradation | 2.368164e-01 | 0.626 |
| R-HSA-4086398 | Ca2+ pathway | 2.961061e-01 | 0.529 |
| R-HSA-195721 | Signaling by WNT | 2.564033e-01 | 0.591 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.039971e-01 | 0.690 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.040466e-01 | 0.517 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.171534e-01 | 0.663 |
| R-HSA-198203 | PI3K/AKT activation | 1.600794e-01 | 0.796 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.932368e-01 | 0.714 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.932368e-01 | 0.714 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.932368e-01 | 0.714 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.656243e-01 | 0.576 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.318896e-01 | 0.635 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.823317e-01 | 0.739 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.039971e-01 | 0.690 |
| R-HSA-1181150 | Signaling by NODAL | 2.850923e-01 | 0.545 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.736169e-01 | 0.760 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.850923e-01 | 0.545 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.040466e-01 | 0.517 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.469558e-01 | 0.607 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.363753e-01 | 0.626 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.600794e-01 | 0.796 |
| R-HSA-162592 | Integration of provirus | 1.823317e-01 | 0.739 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.122599e-01 | 0.673 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.714075e-01 | 0.566 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.792974e-01 | 0.554 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.779247e-01 | 0.750 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.812956e-01 | 0.551 |
| R-HSA-5688426 | Deubiquitination | 1.666918e-01 | 0.778 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.250911e-01 | 0.648 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.122599e-01 | 0.673 |
| R-HSA-373755 | Semaphorin interactions | 2.466861e-01 | 0.608 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.845796e-01 | 0.734 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.932368e-01 | 0.714 |
| R-HSA-9842663 | Signaling by LTK | 1.932368e-01 | 0.714 |
| R-HSA-210991 | Basigin interactions | 2.946328e-01 | 0.531 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.812956e-01 | 0.551 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.083655e-01 | 0.511 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.612659e-01 | 0.583 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.010339e-01 | 0.521 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.581044e-01 | 0.588 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.581044e-01 | 0.588 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.859517e-01 | 0.731 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.250911e-01 | 0.648 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.656243e-01 | 0.576 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.850923e-01 | 0.545 |
| R-HSA-373753 | Nephrin family interactions | 2.850923e-01 | 0.545 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.040466e-01 | 0.517 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.133353e-01 | 0.504 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.059561e-01 | 0.514 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.961061e-01 | 0.529 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.946328e-01 | 0.531 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.018107e-01 | 0.520 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.565704e-01 | 0.591 |
| R-HSA-109582 | Hemostasis | 2.860445e-01 | 0.544 |
| R-HSA-75153 | Apoptotic execution phase | 1.641442e-01 | 0.785 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.122599e-01 | 0.673 |
| R-HSA-216083 | Integrin cell surface interactions | 3.206811e-01 | 0.494 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.225005e-01 | 0.491 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.225005e-01 | 0.491 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.225005e-01 | 0.491 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.225005e-01 | 0.491 |
| R-HSA-3000170 | Syndecan interactions | 3.225005e-01 | 0.491 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.225005e-01 | 0.491 |
| R-HSA-1266738 | Developmental Biology | 3.235984e-01 | 0.490 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.255733e-01 | 0.487 |
| R-HSA-9659379 | Sensory processing of sound | 3.255733e-01 | 0.487 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.266060e-01 | 0.486 |
| R-HSA-6806834 | Signaling by MET | 3.304565e-01 | 0.481 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.315441e-01 | 0.479 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.315441e-01 | 0.479 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 3.315441e-01 | 0.479 |
| R-HSA-1474244 | Extracellular matrix organization | 3.324159e-01 | 0.478 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.375390e-01 | 0.472 |
| R-HSA-9620244 | Long-term potentiation | 3.404674e-01 | 0.468 |
| R-HSA-9839394 | TGFBR3 expression | 3.404674e-01 | 0.468 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.404674e-01 | 0.468 |
| R-HSA-2453864 | Retinoid cycle disease events | 3.404674e-01 | 0.468 |
| R-HSA-9675143 | Diseases of the neuronal system | 3.404674e-01 | 0.468 |
| R-HSA-2474795 | Diseases associated with visual transduction | 3.404674e-01 | 0.468 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.477631e-01 | 0.459 |
| R-HSA-3295583 | TRP channels | 3.492722e-01 | 0.457 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.492722e-01 | 0.457 |
| R-HSA-1500620 | Meiosis | 3.547140e-01 | 0.450 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.579600e-01 | 0.446 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.579600e-01 | 0.446 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.579600e-01 | 0.446 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.579600e-01 | 0.446 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.579600e-01 | 0.446 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.579600e-01 | 0.446 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.579600e-01 | 0.446 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.643327e-01 | 0.439 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.665323e-01 | 0.436 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.666481e-01 | 0.436 |
| R-HSA-9824446 | Viral Infection Pathways | 3.723559e-01 | 0.429 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.749907e-01 | 0.426 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 3.749907e-01 | 0.426 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.749907e-01 | 0.426 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.749907e-01 | 0.426 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.749907e-01 | 0.426 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.810357e-01 | 0.419 |
| R-HSA-2424491 | DAP12 signaling | 3.833366e-01 | 0.416 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.833366e-01 | 0.416 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.833366e-01 | 0.416 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.833366e-01 | 0.416 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.833366e-01 | 0.416 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.881326e-01 | 0.411 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 3.915716e-01 | 0.407 |
| R-HSA-182971 | EGFR downregulation | 3.915716e-01 | 0.407 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.915716e-01 | 0.407 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.915716e-01 | 0.407 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.915716e-01 | 0.407 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.919457e-01 | 0.407 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.919457e-01 | 0.407 |
| R-HSA-418990 | Adherens junctions interactions | 3.961152e-01 | 0.402 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.062916e-01 | 0.391 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.068888e-01 | 0.391 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.077147e-01 | 0.390 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.077147e-01 | 0.390 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.077147e-01 | 0.390 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.077147e-01 | 0.390 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.077147e-01 | 0.390 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.077147e-01 | 0.390 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.155170e-01 | 0.381 |
| R-HSA-390522 | Striated Muscle Contraction | 4.156256e-01 | 0.381 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.156256e-01 | 0.381 |
| R-HSA-2024101 | CS/DS degradation | 4.156256e-01 | 0.381 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.156256e-01 | 0.381 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.156256e-01 | 0.381 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.205378e-01 | 0.376 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.207736e-01 | 0.376 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 4.234314e-01 | 0.373 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.234314e-01 | 0.373 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.234314e-01 | 0.373 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.234314e-01 | 0.373 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.253652e-01 | 0.371 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.260840e-01 | 0.371 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.276191e-01 | 0.369 |
| R-HSA-381042 | PERK regulates gene expression | 4.311334e-01 | 0.365 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.344915e-01 | 0.362 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.387329e-01 | 0.358 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.387329e-01 | 0.358 |
| R-HSA-8853659 | RET signaling | 4.387329e-01 | 0.358 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.462314e-01 | 0.350 |
| R-HSA-419037 | NCAM1 interactions | 4.462314e-01 | 0.350 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 4.462314e-01 | 0.350 |
| R-HSA-8948216 | Collagen chain trimerization | 4.462314e-01 | 0.350 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.480340e-01 | 0.349 |
| R-HSA-1483255 | PI Metabolism | 4.480340e-01 | 0.349 |
| R-HSA-8939211 | ESR-mediated signaling | 4.527364e-01 | 0.344 |
| R-HSA-1566948 | Elastic fibre formation | 4.536302e-01 | 0.343 |
| R-HSA-8875878 | MET promotes cell motility | 4.536302e-01 | 0.343 |
| R-HSA-69541 | Stabilization of p53 | 4.609306e-01 | 0.336 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.609306e-01 | 0.336 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.609306e-01 | 0.336 |
| R-HSA-1280218 | Adaptive Immune System | 4.637424e-01 | 0.334 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.659830e-01 | 0.332 |
| R-HSA-202433 | Generation of second messenger molecules | 4.681338e-01 | 0.330 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.681338e-01 | 0.330 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.681338e-01 | 0.330 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.681338e-01 | 0.330 |
| R-HSA-5260271 | Diseases of Immune System | 4.681338e-01 | 0.330 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.681338e-01 | 0.330 |
| R-HSA-1500931 | Cell-Cell communication | 4.702344e-01 | 0.328 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.745638e-01 | 0.324 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.752413e-01 | 0.323 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.752413e-01 | 0.323 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.752413e-01 | 0.323 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.752413e-01 | 0.323 |
| R-HSA-9607240 | FLT3 Signaling | 4.752413e-01 | 0.323 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.788681e-01 | 0.320 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.789106e-01 | 0.320 |
| R-HSA-8953854 | Metabolism of RNA | 4.796341e-01 | 0.319 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.822542e-01 | 0.317 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.881437e-01 | 0.311 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.891738e-01 | 0.311 |
| R-HSA-73928 | Depyrimidination | 4.891738e-01 | 0.311 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.891738e-01 | 0.311 |
| R-HSA-165159 | MTOR signalling | 4.891738e-01 | 0.311 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.891738e-01 | 0.311 |
| R-HSA-421270 | Cell-cell junction organization | 4.933574e-01 | 0.307 |
| R-HSA-8854214 | TBC/RABGAPs | 4.960014e-01 | 0.305 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.960014e-01 | 0.305 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.960014e-01 | 0.305 |
| R-HSA-2172127 | DAP12 interactions | 5.027381e-01 | 0.299 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.027381e-01 | 0.299 |
| R-HSA-373752 | Netrin-1 signaling | 5.027381e-01 | 0.299 |
| R-HSA-9907900 | Proteasome assembly | 5.027381e-01 | 0.299 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.093852e-01 | 0.293 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.093852e-01 | 0.293 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 5.093852e-01 | 0.293 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.159438e-01 | 0.287 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.159438e-01 | 0.287 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.159438e-01 | 0.287 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.159438e-01 | 0.287 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.170250e-01 | 0.286 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.261617e-01 | 0.279 |
| R-HSA-983712 | Ion channel transport | 5.293965e-01 | 0.276 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.351007e-01 | 0.272 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.351007e-01 | 0.272 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.355954e-01 | 0.271 |
| R-HSA-68875 | Mitotic Prophase | 5.373902e-01 | 0.270 |
| R-HSA-912446 | Meiotic recombination | 5.474508e-01 | 0.262 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.535028e-01 | 0.257 |
| R-HSA-72187 | mRNA 3'-end processing | 5.535028e-01 | 0.257 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.535028e-01 | 0.257 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.535028e-01 | 0.257 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.594742e-01 | 0.252 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.594742e-01 | 0.252 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.610416e-01 | 0.251 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.610416e-01 | 0.251 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.610416e-01 | 0.251 |
| R-HSA-194138 | Signaling by VEGF | 5.610416e-01 | 0.251 |
| R-HSA-72649 | Translation initiation complex formation | 5.653662e-01 | 0.248 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.653662e-01 | 0.248 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.653662e-01 | 0.248 |
| R-HSA-446728 | Cell junction organization | 5.678182e-01 | 0.246 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 5.711797e-01 | 0.243 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.711797e-01 | 0.243 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.733571e-01 | 0.242 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.769158e-01 | 0.239 |
| R-HSA-75893 | TNF signaling | 5.769158e-01 | 0.239 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.769158e-01 | 0.239 |
| R-HSA-5578775 | Ion homeostasis | 5.769158e-01 | 0.239 |
| R-HSA-177929 | Signaling by EGFR | 5.769158e-01 | 0.239 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.769158e-01 | 0.239 |
| R-HSA-1474165 | Reproduction | 5.838211e-01 | 0.234 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.881599e-01 | 0.231 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.912191e-01 | 0.228 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.936699e-01 | 0.226 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.936699e-01 | 0.226 |
| R-HSA-977443 | GABA receptor activation | 5.991065e-01 | 0.222 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.991065e-01 | 0.222 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.044707e-01 | 0.219 |
| R-HSA-211976 | Endogenous sterols | 6.044707e-01 | 0.219 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.097635e-01 | 0.215 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.097635e-01 | 0.215 |
| R-HSA-9707616 | Heme signaling | 6.097635e-01 | 0.215 |
| R-HSA-186797 | Signaling by PDGF | 6.097635e-01 | 0.215 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.149857e-01 | 0.211 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.149857e-01 | 0.211 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.149857e-01 | 0.211 |
| R-HSA-8848021 | Signaling by PTK6 | 6.149857e-01 | 0.211 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.198329e-01 | 0.208 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.201384e-01 | 0.208 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.302388e-01 | 0.200 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.351882e-01 | 0.197 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.351882e-01 | 0.197 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.400718e-01 | 0.194 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.400718e-01 | 0.194 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.496445e-01 | 0.187 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.496445e-01 | 0.187 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.496445e-01 | 0.187 |
| R-HSA-166520 | Signaling by NTRKs | 6.534093e-01 | 0.185 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.534093e-01 | 0.185 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.543354e-01 | 0.184 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.543354e-01 | 0.184 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.543354e-01 | 0.184 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.543354e-01 | 0.184 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.543354e-01 | 0.184 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.543354e-01 | 0.184 |
| R-HSA-9679506 | SARS-CoV Infections | 6.561694e-01 | 0.183 |
| R-HSA-72312 | rRNA processing | 6.585498e-01 | 0.181 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.630126e-01 | 0.178 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.635304e-01 | 0.178 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.680362e-01 | 0.175 |
| R-HSA-1989781 | PPARA activates gene expression | 6.754845e-01 | 0.170 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.768684e-01 | 0.169 |
| R-HSA-5689603 | UCH proteinases | 6.768684e-01 | 0.169 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.815791e-01 | 0.166 |
| R-HSA-1643685 | Disease | 6.847575e-01 | 0.164 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.854667e-01 | 0.164 |
| R-HSA-877300 | Interferon gamma signaling | 6.875804e-01 | 0.163 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.938372e-01 | 0.159 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.938372e-01 | 0.159 |
| R-HSA-977225 | Amyloid fiber formation | 6.979389e-01 | 0.156 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.979389e-01 | 0.156 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.979389e-01 | 0.156 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.019860e-01 | 0.154 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.059790e-01 | 0.151 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.059790e-01 | 0.151 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.099188e-01 | 0.149 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.138061e-01 | 0.146 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.138061e-01 | 0.146 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.174194e-01 | 0.144 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.243596e-01 | 0.140 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.271768e-01 | 0.138 |
| R-HSA-156902 | Peptide chain elongation | 7.288434e-01 | 0.137 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.288434e-01 | 0.137 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.296831e-01 | 0.137 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.310672e-01 | 0.136 |
| R-HSA-73884 | Base Excision Repair | 7.360644e-01 | 0.133 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.360644e-01 | 0.133 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.360644e-01 | 0.133 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.396028e-01 | 0.131 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.430940e-01 | 0.129 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.437799e-01 | 0.129 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.465386e-01 | 0.127 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.465386e-01 | 0.127 |
| R-HSA-2559583 | Cellular Senescence | 7.476354e-01 | 0.126 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.499373e-01 | 0.125 |
| R-HSA-1474290 | Collagen formation | 7.532905e-01 | 0.123 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.562121e-01 | 0.121 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.565990e-01 | 0.121 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.565990e-01 | 0.121 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.571477e-01 | 0.121 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.598634e-01 | 0.119 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.598634e-01 | 0.119 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.630841e-01 | 0.117 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.661994e-01 | 0.116 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.693972e-01 | 0.114 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.693972e-01 | 0.114 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.693972e-01 | 0.114 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.724907e-01 | 0.112 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.737831e-01 | 0.111 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.755428e-01 | 0.110 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.760395e-01 | 0.110 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.785542e-01 | 0.109 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.785542e-01 | 0.109 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.785542e-01 | 0.109 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.804936e-01 | 0.108 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.815254e-01 | 0.107 |
| R-HSA-192823 | Viral mRNA Translation | 7.844569e-01 | 0.105 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.851798e-01 | 0.105 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.873493e-01 | 0.104 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.873493e-01 | 0.104 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.873493e-01 | 0.104 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.902030e-01 | 0.102 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.902030e-01 | 0.102 |
| R-HSA-9833110 | RSV-host interactions | 7.902030e-01 | 0.102 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.930186e-01 | 0.101 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.930186e-01 | 0.101 |
| R-HSA-418346 | Platelet homeostasis | 7.957965e-01 | 0.099 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.976984e-01 | 0.098 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.985374e-01 | 0.098 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.985374e-01 | 0.098 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.012416e-01 | 0.096 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.012416e-01 | 0.096 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.012416e-01 | 0.096 |
| R-HSA-72172 | mRNA Splicing | 8.036320e-01 | 0.095 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.039097e-01 | 0.095 |
| R-HSA-202403 | TCR signaling | 8.065422e-01 | 0.093 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.065422e-01 | 0.093 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.065422e-01 | 0.093 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.065422e-01 | 0.093 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.117020e-01 | 0.091 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.117020e-01 | 0.091 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.117020e-01 | 0.091 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.142304e-01 | 0.089 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.167249e-01 | 0.088 |
| R-HSA-397014 | Muscle contraction | 8.190796e-01 | 0.087 |
| R-HSA-166663 | Initial triggering of complement | 8.191861e-01 | 0.087 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.216143e-01 | 0.085 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.240101e-01 | 0.084 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.263739e-01 | 0.083 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.263739e-01 | 0.083 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.287061e-01 | 0.082 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.287061e-01 | 0.082 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.287061e-01 | 0.082 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.332773e-01 | 0.079 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.332773e-01 | 0.079 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.377271e-01 | 0.077 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.399075e-01 | 0.076 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.399075e-01 | 0.076 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.420587e-01 | 0.075 |
| R-HSA-977606 | Regulation of Complement cascade | 8.462752e-01 | 0.072 |
| R-HSA-114608 | Platelet degranulation | 8.523907e-01 | 0.069 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.543749e-01 | 0.068 |
| R-HSA-9843745 | Adipogenesis | 8.620497e-01 | 0.064 |
| R-HSA-5576891 | Cardiac conduction | 8.620497e-01 | 0.064 |
| R-HSA-9909396 | Circadian clock | 8.639046e-01 | 0.064 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.657347e-01 | 0.063 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.745243e-01 | 0.058 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.762122e-01 | 0.057 |
| R-HSA-6807070 | PTEN Regulation | 8.778776e-01 | 0.057 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.843188e-01 | 0.053 |
| R-HSA-6798695 | Neutrophil degranulation | 8.856077e-01 | 0.053 |
| R-HSA-166658 | Complement cascade | 8.889268e-01 | 0.051 |
| R-HSA-5663205 | Infectious disease | 8.892403e-01 | 0.051 |
| R-HSA-2187338 | Visual phototransduction | 8.918968e-01 | 0.050 |
| R-HSA-9758941 | Gastrulation | 8.947878e-01 | 0.048 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.989806e-01 | 0.046 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.989806e-01 | 0.046 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.030070e-01 | 0.044 |
| R-HSA-162587 | HIV Life Cycle | 9.056022e-01 | 0.043 |
| R-HSA-9711097 | Cellular response to starvation | 9.068737e-01 | 0.042 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.141527e-01 | 0.039 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.175769e-01 | 0.037 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.240228e-01 | 0.034 |
| R-HSA-1483257 | Phospholipid metabolism | 9.255522e-01 | 0.034 |
| R-HSA-168255 | Influenza Infection | 9.309114e-01 | 0.031 |
| R-HSA-3781865 | Diseases of glycosylation | 9.354477e-01 | 0.029 |
| R-HSA-449147 | Signaling by Interleukins | 9.364354e-01 | 0.029 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.428787e-01 | 0.026 |
| R-HSA-8957322 | Metabolism of steroids | 9.461309e-01 | 0.024 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.480642e-01 | 0.023 |
| R-HSA-428157 | Sphingolipid metabolism | 9.487657e-01 | 0.023 |
| R-HSA-168256 | Immune System | 9.502334e-01 | 0.022 |
| R-HSA-8951664 | Neddylation | 9.615010e-01 | 0.017 |
| R-HSA-162906 | HIV Infection | 9.645221e-01 | 0.016 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.690417e-01 | 0.014 |
| R-HSA-157118 | Signaling by NOTCH | 9.702823e-01 | 0.013 |
| R-HSA-168249 | Innate Immune System | 9.759795e-01 | 0.011 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.769590e-01 | 0.010 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.823093e-01 | 0.008 |
| R-HSA-72766 | Translation | 9.841829e-01 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 9.923863e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.933024e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.945368e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.945560e-01 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.962447e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.977447e-01 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.984680e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.994027e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.997615e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.998409e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999928e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999956e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.868 | 0.833 | 2 | 0.817 |
CLK3 |
0.814 | 0.200 | 1 | 0.877 |
COT |
0.811 | 0.058 | 2 | 0.173 |
MOS |
0.801 | 0.052 | 1 | 0.844 |
CDC7 |
0.801 | -0.008 | 1 | 0.820 |
PIM3 |
0.799 | 0.039 | -3 | 0.826 |
MARK4 |
0.798 | 0.090 | 4 | 0.922 |
ERK5 |
0.798 | 0.053 | 1 | 0.868 |
PRPK |
0.798 | -0.009 | -1 | 0.856 |
SKMLCK |
0.797 | 0.109 | -2 | 0.889 |
ATR |
0.797 | 0.074 | 1 | 0.857 |
NLK |
0.797 | 0.016 | 1 | 0.845 |
HIPK4 |
0.796 | 0.054 | 1 | 0.833 |
CAMK1B |
0.796 | 0.023 | -3 | 0.847 |
CAMK2G |
0.796 | 0.064 | 2 | 0.241 |
DSTYK |
0.796 | 0.069 | 2 | 0.221 |
CDKL1 |
0.795 | 0.038 | -3 | 0.805 |
CDKL5 |
0.795 | 0.046 | -3 | 0.795 |
PRKD1 |
0.794 | 0.031 | -3 | 0.808 |
NDR2 |
0.794 | -0.013 | -3 | 0.827 |
ATM |
0.793 | 0.149 | 1 | 0.816 |
KIS |
0.793 | 0.062 | 1 | 0.772 |
GCN2 |
0.793 | -0.145 | 2 | 0.107 |
TSSK2 |
0.791 | 0.053 | -5 | 0.873 |
GRK1 |
0.791 | 0.087 | -2 | 0.826 |
IKKB |
0.791 | -0.026 | -2 | 0.767 |
PDHK4 |
0.791 | 0.023 | 1 | 0.807 |
CAMK2B |
0.791 | 0.183 | 2 | 0.330 |
BMPR2 |
0.790 | -0.011 | -2 | 0.890 |
CAMLCK |
0.789 | 0.039 | -2 | 0.887 |
SRPK1 |
0.789 | 0.072 | -3 | 0.751 |
RAF1 |
0.789 | -0.090 | 1 | 0.779 |
RSK2 |
0.789 | 0.036 | -3 | 0.776 |
TBK1 |
0.788 | -0.071 | 1 | 0.668 |
ICK |
0.788 | 0.047 | -3 | 0.834 |
PIM1 |
0.788 | 0.057 | -3 | 0.768 |
ULK2 |
0.787 | -0.165 | 2 | 0.110 |
AMPKA1 |
0.787 | -0.000 | -3 | 0.821 |
PKN3 |
0.787 | -0.017 | -3 | 0.807 |
TSSK1 |
0.787 | 0.024 | -3 | 0.839 |
MTOR |
0.787 | -0.085 | 1 | 0.768 |
CAMK2D |
0.786 | 0.099 | -3 | 0.819 |
PRKD2 |
0.786 | 0.017 | -3 | 0.758 |
TGFBR2 |
0.786 | -0.046 | -2 | 0.824 |
NUAK2 |
0.786 | -0.019 | -3 | 0.820 |
MLK1 |
0.786 | -0.102 | 2 | 0.122 |
P90RSK |
0.785 | 0.013 | -3 | 0.777 |
NDR1 |
0.785 | -0.040 | -3 | 0.816 |
DAPK2 |
0.785 | 0.010 | -3 | 0.851 |
CDK8 |
0.785 | 0.054 | 1 | 0.746 |
RSK3 |
0.784 | 0.008 | -3 | 0.771 |
IKKA |
0.784 | 0.010 | -2 | 0.750 |
DYRK2 |
0.784 | 0.081 | 1 | 0.771 |
NIK |
0.784 | -0.071 | -3 | 0.854 |
MARK2 |
0.784 | 0.090 | 4 | 0.861 |
LATS1 |
0.783 | 0.168 | -3 | 0.852 |
NIM1 |
0.783 | -0.061 | 3 | 0.802 |
BMPR1B |
0.783 | 0.104 | 1 | 0.744 |
NEK6 |
0.782 | -0.105 | -2 | 0.848 |
PDHK1 |
0.782 | -0.142 | 1 | 0.792 |
RIPK3 |
0.782 | -0.074 | 3 | 0.762 |
IKKE |
0.782 | -0.088 | 1 | 0.661 |
PKCD |
0.782 | -0.040 | 2 | 0.102 |
AMPKA2 |
0.782 | 0.004 | -3 | 0.795 |
HUNK |
0.782 | -0.121 | 2 | 0.111 |
BRSK1 |
0.782 | 0.015 | -3 | 0.774 |
QSK |
0.782 | 0.036 | 4 | 0.911 |
WNK1 |
0.782 | -0.051 | -2 | 0.891 |
NEK7 |
0.781 | -0.145 | -3 | 0.843 |
MST4 |
0.781 | -0.060 | 2 | 0.123 |
MLK3 |
0.781 | -0.070 | 2 | 0.097 |
P70S6KB |
0.780 | -0.010 | -3 | 0.786 |
WNK3 |
0.780 | -0.144 | 1 | 0.774 |
CDK5 |
0.780 | 0.070 | 1 | 0.766 |
CAMK2A |
0.780 | 0.072 | 2 | 0.249 |
SRPK2 |
0.780 | 0.057 | -3 | 0.685 |
BCKDK |
0.780 | -0.077 | -1 | 0.807 |
MAPKAPK2 |
0.779 | 0.049 | -3 | 0.728 |
MARK3 |
0.779 | 0.064 | 4 | 0.887 |
CLK2 |
0.779 | 0.123 | -3 | 0.742 |
SIK |
0.779 | 0.022 | -3 | 0.752 |
CLK4 |
0.779 | 0.073 | -3 | 0.756 |
CHAK2 |
0.779 | -0.095 | -1 | 0.826 |
RSK4 |
0.778 | 0.044 | -3 | 0.751 |
CDK7 |
0.778 | 0.042 | 1 | 0.749 |
CDK19 |
0.778 | 0.047 | 1 | 0.714 |
TGFBR1 |
0.778 | 0.080 | -2 | 0.844 |
TTBK2 |
0.778 | -0.159 | 2 | 0.082 |
ULK1 |
0.778 | -0.170 | -3 | 0.796 |
PAK1 |
0.777 | -0.028 | -2 | 0.834 |
DYRK4 |
0.777 | 0.100 | 1 | 0.707 |
GRK4 |
0.777 | -0.059 | -2 | 0.839 |
SSTK |
0.777 | 0.040 | 4 | 0.889 |
GRK6 |
0.777 | -0.024 | 1 | 0.770 |
LATS2 |
0.777 | -0.022 | -5 | 0.747 |
PKACG |
0.777 | -0.002 | -2 | 0.790 |
CDK1 |
0.777 | 0.088 | 1 | 0.695 |
MSK2 |
0.777 | 0.020 | -3 | 0.745 |
PRKD3 |
0.777 | 0.006 | -3 | 0.741 |
ALK2 |
0.777 | 0.144 | -2 | 0.855 |
PKN2 |
0.777 | -0.086 | -3 | 0.801 |
MAPKAPK3 |
0.776 | -0.015 | -3 | 0.760 |
ERK7 |
0.776 | -0.015 | 2 | 0.059 |
IRE2 |
0.776 | -0.093 | 2 | 0.090 |
MARK1 |
0.776 | 0.063 | 4 | 0.893 |
JNK3 |
0.776 | 0.069 | 1 | 0.725 |
PAK3 |
0.776 | -0.053 | -2 | 0.832 |
GRK5 |
0.776 | -0.127 | -3 | 0.818 |
DNAPK |
0.776 | 0.141 | 1 | 0.738 |
BRSK2 |
0.776 | -0.027 | -3 | 0.787 |
QIK |
0.775 | -0.040 | -3 | 0.814 |
SRPK3 |
0.775 | 0.036 | -3 | 0.731 |
JNK2 |
0.775 | 0.074 | 1 | 0.690 |
AURC |
0.775 | 0.015 | -2 | 0.716 |
IRE1 |
0.775 | -0.135 | 1 | 0.771 |
MLK2 |
0.774 | -0.135 | 2 | 0.115 |
HIPK1 |
0.774 | 0.069 | 1 | 0.780 |
CLK1 |
0.774 | 0.059 | -3 | 0.738 |
MLK4 |
0.774 | -0.083 | 2 | 0.104 |
MASTL |
0.774 | -0.185 | -2 | 0.817 |
RIPK1 |
0.774 | -0.090 | 1 | 0.762 |
MSK1 |
0.774 | 0.051 | -3 | 0.742 |
MNK2 |
0.773 | -0.016 | -2 | 0.824 |
PLK3 |
0.773 | 0.024 | 2 | 0.210 |
MELK |
0.773 | -0.054 | -3 | 0.780 |
ANKRD3 |
0.773 | -0.148 | 1 | 0.802 |
HIPK2 |
0.773 | 0.072 | 1 | 0.695 |
MYLK4 |
0.773 | 0.028 | -2 | 0.822 |
NUAK1 |
0.772 | -0.038 | -3 | 0.780 |
PKCB |
0.772 | -0.067 | 2 | 0.080 |
P38B |
0.772 | 0.082 | 1 | 0.727 |
ALK4 |
0.772 | -0.007 | -2 | 0.870 |
SMG1 |
0.772 | 0.035 | 1 | 0.827 |
P38A |
0.772 | 0.059 | 1 | 0.783 |
PKR |
0.772 | -0.047 | 1 | 0.806 |
CDK18 |
0.772 | 0.049 | 1 | 0.685 |
PAK2 |
0.771 | -0.044 | -2 | 0.821 |
DYRK1A |
0.771 | 0.048 | 1 | 0.797 |
PKCA |
0.771 | -0.075 | 2 | 0.078 |
DLK |
0.770 | -0.146 | 1 | 0.773 |
BMPR1A |
0.770 | 0.103 | 1 | 0.729 |
MNK1 |
0.770 | -0.021 | -2 | 0.835 |
CAMK4 |
0.770 | -0.080 | -3 | 0.794 |
ERK2 |
0.770 | 0.028 | 1 | 0.746 |
CDK3 |
0.770 | 0.113 | 1 | 0.650 |
NEK9 |
0.770 | -0.203 | 2 | 0.100 |
ERK1 |
0.770 | 0.042 | 1 | 0.714 |
SNRK |
0.769 | -0.130 | 2 | 0.085 |
PKACB |
0.769 | 0.038 | -2 | 0.729 |
PKG2 |
0.769 | 0.007 | -2 | 0.731 |
CHK1 |
0.769 | 0.009 | -3 | 0.816 |
AURB |
0.769 | 0.008 | -2 | 0.712 |
PIM2 |
0.768 | 0.026 | -3 | 0.742 |
GRK7 |
0.768 | 0.013 | 1 | 0.717 |
VRK2 |
0.767 | -0.178 | 1 | 0.854 |
ACVR2B |
0.767 | 0.022 | -2 | 0.824 |
HIPK3 |
0.767 | 0.037 | 1 | 0.778 |
PHKG1 |
0.767 | -0.109 | -3 | 0.800 |
CDK2 |
0.767 | 0.062 | 1 | 0.745 |
PKCH |
0.767 | -0.093 | 2 | 0.078 |
ACVR2A |
0.767 | 0.012 | -2 | 0.808 |
PKCG |
0.767 | -0.094 | 2 | 0.079 |
MEK1 |
0.766 | -0.136 | 2 | 0.150 |
P38G |
0.766 | 0.053 | 1 | 0.626 |
PAK6 |
0.766 | -0.031 | -2 | 0.762 |
DYRK1B |
0.766 | 0.071 | 1 | 0.723 |
CDK17 |
0.766 | 0.047 | 1 | 0.628 |
CDK13 |
0.766 | 0.021 | 1 | 0.724 |
AKT2 |
0.765 | 0.020 | -3 | 0.690 |
AURA |
0.765 | 0.027 | -2 | 0.683 |
PRKX |
0.765 | 0.054 | -3 | 0.668 |
PLK4 |
0.765 | -0.143 | 2 | 0.079 |
DYRK3 |
0.764 | 0.064 | 1 | 0.780 |
PKCZ |
0.764 | -0.098 | 2 | 0.087 |
TLK2 |
0.764 | -0.081 | 1 | 0.785 |
PLK1 |
0.763 | -0.103 | -2 | 0.799 |
CHAK1 |
0.763 | -0.163 | 2 | 0.072 |
CAMK1G |
0.763 | -0.032 | -3 | 0.755 |
P38D |
0.762 | 0.065 | 1 | 0.677 |
DCAMKL1 |
0.761 | -0.049 | -3 | 0.763 |
SGK3 |
0.761 | -0.032 | -3 | 0.738 |
PERK |
0.761 | -0.134 | -2 | 0.851 |
BRAF |
0.761 | -0.030 | -4 | 0.846 |
CAMK1D |
0.761 | 0.042 | -3 | 0.684 |
CDK14 |
0.761 | 0.035 | 1 | 0.711 |
PLK2 |
0.760 | 0.068 | -3 | 0.855 |
MAK |
0.759 | 0.097 | -2 | 0.775 |
IRAK4 |
0.759 | -0.133 | 1 | 0.782 |
DCAMKL2 |
0.759 | -0.069 | -3 | 0.793 |
CDK12 |
0.759 | 0.019 | 1 | 0.699 |
MAPKAPK5 |
0.759 | -0.028 | -3 | 0.714 |
MPSK1 |
0.759 | -0.004 | 1 | 0.769 |
CDK16 |
0.759 | 0.047 | 1 | 0.650 |
CDK9 |
0.758 | 0.008 | 1 | 0.729 |
NEK2 |
0.758 | -0.177 | 2 | 0.087 |
PRP4 |
0.758 | -0.013 | -3 | 0.677 |
YSK4 |
0.758 | -0.165 | 1 | 0.711 |
PINK1 |
0.758 | -0.089 | 1 | 0.826 |
TTBK1 |
0.757 | -0.141 | 2 | 0.067 |
MEKK2 |
0.757 | -0.133 | 2 | 0.110 |
SMMLCK |
0.757 | -0.001 | -3 | 0.805 |
PKCT |
0.757 | -0.080 | 2 | 0.077 |
PASK |
0.757 | 0.005 | -3 | 0.848 |
GRK2 |
0.756 | -0.056 | -2 | 0.740 |
TLK1 |
0.756 | -0.092 | -2 | 0.838 |
WNK4 |
0.756 | -0.119 | -2 | 0.879 |
MEKK1 |
0.756 | -0.156 | 1 | 0.773 |
AKT1 |
0.755 | 0.009 | -3 | 0.699 |
PKACA |
0.755 | 0.029 | -2 | 0.682 |
MEK5 |
0.755 | -0.214 | 2 | 0.124 |
CK1E |
0.755 | -0.050 | -3 | 0.507 |
DAPK3 |
0.755 | 0.046 | -3 | 0.784 |
IRAK1 |
0.755 | -0.080 | -1 | 0.765 |
HRI |
0.754 | -0.163 | -2 | 0.856 |
MEKK3 |
0.754 | -0.150 | 1 | 0.743 |
JNK1 |
0.754 | 0.053 | 1 | 0.669 |
ZAK |
0.753 | -0.158 | 1 | 0.724 |
P70S6K |
0.753 | -0.036 | -3 | 0.707 |
NEK5 |
0.753 | -0.147 | 1 | 0.805 |
MOK |
0.753 | 0.074 | 1 | 0.807 |
CDK10 |
0.752 | 0.028 | 1 | 0.700 |
DRAK1 |
0.751 | -0.136 | 1 | 0.651 |
PHKG2 |
0.750 | -0.105 | -3 | 0.768 |
PKCE |
0.749 | -0.049 | 2 | 0.072 |
MST3 |
0.748 | -0.132 | 2 | 0.091 |
GAK |
0.748 | -0.026 | 1 | 0.806 |
CDK6 |
0.748 | 0.027 | 1 | 0.702 |
PKCI |
0.748 | -0.090 | 2 | 0.078 |
CK1D |
0.747 | -0.028 | -3 | 0.450 |
TAO3 |
0.747 | -0.105 | 1 | 0.742 |
SBK |
0.746 | 0.055 | -3 | 0.583 |
AKT3 |
0.746 | 0.020 | -3 | 0.630 |
PAK4 |
0.745 | -0.041 | -2 | 0.702 |
NEK8 |
0.745 | -0.170 | 2 | 0.099 |
CDK4 |
0.745 | 0.028 | 1 | 0.687 |
GRK3 |
0.745 | -0.048 | -2 | 0.704 |
CK1G1 |
0.744 | -0.086 | -3 | 0.504 |
YANK3 |
0.744 | -0.059 | 2 | 0.074 |
CAMK1A |
0.744 | 0.005 | -3 | 0.653 |
SGK1 |
0.744 | 0.021 | -3 | 0.615 |
DAPK1 |
0.744 | 0.016 | -3 | 0.768 |
PAK5 |
0.744 | -0.052 | -2 | 0.700 |
EEF2K |
0.743 | -0.084 | 3 | 0.824 |
CK2A2 |
0.743 | 0.034 | 1 | 0.629 |
GSK3A |
0.743 | -0.011 | 4 | 0.403 |
PKN1 |
0.743 | -0.060 | -3 | 0.716 |
BUB1 |
0.742 | 0.004 | -5 | 0.848 |
PDK1 |
0.742 | -0.105 | 1 | 0.737 |
TAO2 |
0.742 | -0.132 | 2 | 0.124 |
LKB1 |
0.742 | -0.108 | -3 | 0.795 |
CAMKK1 |
0.742 | -0.126 | -2 | 0.781 |
CHK2 |
0.741 | -0.019 | -3 | 0.633 |
MEKK6 |
0.741 | -0.161 | 1 | 0.779 |
CK1A2 |
0.740 | -0.056 | -3 | 0.451 |
GSK3B |
0.740 | -0.040 | 4 | 0.396 |
ROCK2 |
0.740 | 0.005 | -3 | 0.761 |
TAK1 |
0.739 | -0.118 | 1 | 0.775 |
MST2 |
0.739 | -0.112 | 1 | 0.750 |
MAP3K15 |
0.738 | -0.151 | 1 | 0.716 |
MRCKB |
0.738 | -0.006 | -3 | 0.722 |
TNIK |
0.738 | -0.062 | 3 | 0.859 |
NEK11 |
0.737 | -0.223 | 1 | 0.719 |
STK33 |
0.737 | -0.144 | 2 | 0.076 |
LRRK2 |
0.736 | -0.157 | 2 | 0.121 |
MRCKA |
0.736 | -0.012 | -3 | 0.740 |
NEK4 |
0.736 | -0.175 | 1 | 0.750 |
HGK |
0.736 | -0.102 | 3 | 0.848 |
CAMKK2 |
0.735 | -0.133 | -2 | 0.778 |
MINK |
0.735 | -0.087 | 1 | 0.731 |
ALPHAK3 |
0.735 | 0.108 | -1 | 0.769 |
VRK1 |
0.734 | -0.181 | 2 | 0.110 |
GCK |
0.734 | -0.102 | 1 | 0.721 |
PKG1 |
0.734 | -0.014 | -2 | 0.657 |
TTK |
0.734 | -0.042 | -2 | 0.820 |
NEK1 |
0.733 | -0.155 | 1 | 0.764 |
DMPK1 |
0.732 | 0.028 | -3 | 0.742 |
PBK |
0.732 | -0.043 | 1 | 0.756 |
CK2A1 |
0.732 | 0.021 | 1 | 0.597 |
LOK |
0.731 | -0.139 | -2 | 0.784 |
MEK2 |
0.730 | -0.195 | 2 | 0.115 |
CRIK |
0.729 | 0.014 | -3 | 0.704 |
RIPK2 |
0.729 | -0.181 | 1 | 0.677 |
PDHK3_TYR |
0.728 | 0.066 | 4 | 0.885 |
KHS1 |
0.727 | -0.093 | 1 | 0.718 |
HPK1 |
0.727 | -0.115 | 1 | 0.701 |
EPHA6 |
0.726 | 0.098 | -1 | 0.877 |
YSK1 |
0.726 | -0.167 | 2 | 0.085 |
MST1 |
0.726 | -0.162 | 1 | 0.728 |
KHS2 |
0.725 | -0.071 | 1 | 0.720 |
ROCK1 |
0.725 | -0.011 | -3 | 0.728 |
BIKE |
0.724 | 0.006 | 1 | 0.699 |
SLK |
0.723 | -0.133 | -2 | 0.724 |
EPHB4 |
0.723 | 0.073 | -1 | 0.875 |
NEK3 |
0.722 | -0.168 | 1 | 0.740 |
OSR1 |
0.721 | -0.120 | 2 | 0.095 |
TESK1_TYR |
0.721 | -0.026 | 3 | 0.873 |
EPHA4 |
0.720 | 0.094 | 2 | 0.219 |
PDHK4_TYR |
0.720 | 0.033 | 2 | 0.188 |
MAP2K4_TYR |
0.718 | -0.034 | -1 | 0.870 |
MAP2K6_TYR |
0.718 | 0.028 | -1 | 0.865 |
YES1 |
0.718 | 0.086 | -1 | 0.900 |
ASK1 |
0.718 | -0.141 | 1 | 0.701 |
TYRO3 |
0.718 | -0.010 | 3 | 0.812 |
HASPIN |
0.717 | -0.069 | -1 | 0.646 |
ABL2 |
0.717 | 0.077 | -1 | 0.838 |
MAP2K7_TYR |
0.716 | -0.124 | 2 | 0.166 |
PKMYT1_TYR |
0.716 | -0.085 | 3 | 0.842 |
SRMS |
0.716 | 0.118 | 1 | 0.814 |
BLK |
0.716 | 0.105 | -1 | 0.875 |
TXK |
0.716 | 0.073 | 1 | 0.779 |
BMPR2_TYR |
0.716 | 0.037 | -1 | 0.860 |
EPHB2 |
0.715 | 0.089 | -1 | 0.859 |
LIMK2_TYR |
0.715 | -0.048 | -3 | 0.857 |
PDHK1_TYR |
0.715 | -0.011 | -1 | 0.876 |
FER |
0.715 | 0.063 | 1 | 0.851 |
RET |
0.715 | -0.024 | 1 | 0.773 |
EPHB3 |
0.714 | 0.059 | -1 | 0.869 |
MYO3B |
0.714 | -0.129 | 2 | 0.097 |
HCK |
0.714 | 0.069 | -1 | 0.879 |
ROS1 |
0.713 | -0.066 | 3 | 0.792 |
EPHB1 |
0.713 | 0.038 | 1 | 0.819 |
LCK |
0.713 | 0.076 | -1 | 0.877 |
ABL1 |
0.712 | 0.034 | -1 | 0.839 |
ITK |
0.712 | 0.018 | -1 | 0.853 |
PINK1_TYR |
0.712 | -0.128 | 1 | 0.799 |
EPHA7 |
0.712 | 0.074 | 2 | 0.203 |
FGFR2 |
0.711 | 0.044 | 3 | 0.791 |
MYO3A |
0.711 | -0.135 | 1 | 0.727 |
YANK2 |
0.711 | -0.067 | 2 | 0.103 |
INSRR |
0.711 | 0.065 | 3 | 0.764 |
CSF1R |
0.711 | -0.012 | 3 | 0.794 |
DDR1 |
0.711 | 0.012 | 4 | 0.830 |
TYK2 |
0.710 | -0.098 | 1 | 0.776 |
JAK2 |
0.710 | -0.065 | 1 | 0.778 |
TNK2 |
0.710 | -0.011 | 3 | 0.774 |
AAK1 |
0.709 | 0.025 | 1 | 0.613 |
TAO1 |
0.709 | -0.148 | 1 | 0.678 |
MERTK |
0.709 | 0.022 | 3 | 0.778 |
MST1R |
0.709 | -0.082 | 3 | 0.810 |
LIMK1_TYR |
0.708 | -0.126 | 2 | 0.148 |
CK1A |
0.708 | -0.074 | -3 | 0.360 |
TEK |
0.708 | -0.001 | 3 | 0.758 |
EPHA5 |
0.708 | 0.113 | 2 | 0.242 |
FYN |
0.708 | 0.108 | -1 | 0.856 |
FGR |
0.708 | -0.011 | 1 | 0.817 |
AXL |
0.707 | -0.004 | 3 | 0.790 |
TEC |
0.707 | 0.028 | -1 | 0.812 |
LTK |
0.706 | 0.003 | 3 | 0.743 |
EPHA3 |
0.706 | 0.016 | 2 | 0.193 |
PDGFRB |
0.706 | -0.057 | 3 | 0.810 |
FGFR1 |
0.706 | -0.024 | 3 | 0.776 |
LYN |
0.705 | 0.090 | 3 | 0.714 |
BTK |
0.705 | 0.015 | -1 | 0.831 |
BMX |
0.705 | 0.023 | -1 | 0.774 |
JAK3 |
0.705 | -0.057 | 1 | 0.754 |
ALK |
0.703 | -0.038 | 3 | 0.729 |
EPHA1 |
0.703 | 0.013 | 3 | 0.760 |
KIT |
0.703 | -0.022 | 3 | 0.793 |
STLK3 |
0.702 | -0.189 | 1 | 0.696 |
FLT3 |
0.702 | -0.050 | 3 | 0.792 |
FGFR3 |
0.702 | 0.008 | 3 | 0.771 |
EPHA8 |
0.701 | 0.046 | -1 | 0.846 |
PTK2B |
0.700 | 0.010 | -1 | 0.839 |
INSR |
0.700 | 0.003 | 3 | 0.746 |
DDR2 |
0.700 | 0.072 | 3 | 0.748 |
TNNI3K_TYR |
0.699 | -0.086 | 1 | 0.818 |
MET |
0.699 | -0.044 | 3 | 0.788 |
KDR |
0.699 | -0.080 | 3 | 0.759 |
TNK1 |
0.699 | -0.098 | 3 | 0.785 |
PTK6 |
0.698 | -0.105 | -1 | 0.798 |
SRC |
0.697 | 0.043 | -1 | 0.867 |
PTK2 |
0.697 | 0.042 | -1 | 0.806 |
PDGFRA |
0.697 | -0.128 | 3 | 0.810 |
FRK |
0.697 | -0.034 | -1 | 0.873 |
JAK1 |
0.696 | -0.105 | 1 | 0.704 |
NTRK1 |
0.695 | -0.038 | -1 | 0.835 |
EPHA2 |
0.694 | 0.046 | -1 | 0.810 |
ERBB2 |
0.694 | -0.051 | 1 | 0.703 |
EGFR |
0.693 | 0.026 | 1 | 0.618 |
FGFR4 |
0.693 | 0.027 | -1 | 0.796 |
CSK |
0.692 | -0.022 | 2 | 0.181 |
NEK10_TYR |
0.691 | -0.124 | 1 | 0.645 |
MATK |
0.691 | -0.047 | -1 | 0.742 |
NTRK2 |
0.691 | -0.086 | 3 | 0.766 |
FLT4 |
0.688 | -0.102 | 3 | 0.750 |
WEE1_TYR |
0.688 | -0.108 | -1 | 0.763 |
FLT1 |
0.688 | -0.085 | -1 | 0.834 |
NTRK3 |
0.688 | -0.042 | -1 | 0.790 |
CK1G3 |
0.688 | -0.065 | -3 | 0.312 |
IGF1R |
0.687 | -0.005 | 3 | 0.689 |
SYK |
0.686 | 0.046 | -1 | 0.780 |
ERBB4 |
0.682 | 0.019 | 1 | 0.635 |
CK1G2 |
0.672 | -0.049 | -3 | 0.413 |
FES |
0.671 | -0.061 | -1 | 0.761 |
MUSK |
0.665 | -0.151 | 1 | 0.611 |
ZAP70 |
0.657 | -0.034 | -1 | 0.698 |