Motif 584 (n=68)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S422 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6NF01 | POM121B | S298 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | S691 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00560 | SDCBP | S54 | ochoa | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O14979 | HNRNPDL | S127 | ochoa | Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
| O60861 | GAS7 | S156 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
| O75363 | BCAS1 | S330 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O95071 | UBR5 | S2469 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| P00325 | ADH1B | S23 | ochoa | All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta) | Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387}. |
| P00326 | ADH1C | S23 | ochoa | Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma) | Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. {ECO:0000269|PubMed:6391957}. |
| P01871 | IGHM | S187 | ochoa | Immunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region BOT) (Ig mu chain C region GAL) (Ig mu chain C region OU) | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.; FUNCTION: [Isoform 1]: Constant region of secreted IgM (sIgM), also known as the Fc region of IgM antibody. Able to multimerize, forms high order polymers, mainly pentamers and occasionally hexamers, providing for multivalency and high avidity recognition of antigens (PubMed:32029689, PubMed:37095205). Natural sIgM are polyreactive and recognize conserved self- and pathogen-derived structures, whereas immune sIgM are secreted only upon exposure to pathogens and are antigen-specific. Both natural and immune sIgM are required for an efficient humoral immune response to infection (By similarity). Mediates sIgM effector functions mostly via Fc receptors and the complement system. On lymphoid cells binds high-affinity Fc receptor FCMR and promotes induction of an efficient neutralizing IgG response while maintaining tolerance to self-antigens. Recruits C1q complement component to initiate the classical complement pathway, facilitating the recognition and neutralization of pathogens by the host. Together with C1q and mannose-binding lectin promotes the phagocytosis of apoptotic cells by macrophages, ensuring the clearance of potential autoimmune epitopes from tissues (By similarity) (PubMed:12847249, PubMed:19006321, PubMed:28230186, PubMed:32029689). Involved in mucosal immunity. It is transported by transcytosis across mucosal epithelium by PIGR and secreted on the apical side in complex with PIGR secretory component to scan mucosal lining for pathogens. IgM-antigen complexes undergo FCMR-mediated retrotranscytosis across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (By similarity) (PubMed:32029689). {ECO:0000250|UniProtKB:P01872, ECO:0000269|PubMed:12847249, ECO:0000269|PubMed:19006321, ECO:0000269|PubMed:28230186, ECO:0000269|PubMed:32029689, ECO:0000269|PubMed:37095205}.; FUNCTION: [Isoform 2]: Constant region of membrane-bound IgM, part of the B cell receptor complex (BCR). IgM BCR provides constitutive tonic signaling for B cell survival. Mediates pre-BCR signaling that regulates B cell selection and rearrangement of Ig genes via allelic exclusion. {ECO:0000250|UniProtKB:P01872, ECO:0000269|PubMed:35981043}. |
| P04350 | TUBB4A | S75 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07327 | ADH1A | S23 | ochoa | Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha) | Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060). {ECO:0000269|PubMed:2738060}. |
| P07437 | TUBB | S75 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11766 | ADH5 | S21 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P13798 | APEH | S185 | ochoa | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}. |
| P14649 | MYL6B | S114 | ochoa | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| P14921 | ETS1 | S41 | ochoa | Protein C-ets-1 (p54) | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}. |
| P18583 | SON | S2178 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P53350 | PLK1 | S99 | psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P57721 | PCBP3 | S143 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P60660 | MYL6 | S57 | ochoa | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | Regulatory light chain of myosin. Does not bind calcium. |
| P68371 | TUBB4B | S75 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00872 | MYBPC1 | S550 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q05519 | SRSF11 | S464 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q08188 | TGM3 | S125 | ochoa | Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain] | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. {ECO:0000250}. |
| Q08AD1 | CAMSAP2 | S690 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13509 | TUBB3 | S75 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S75 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14315 | FLNC | S2461 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14966 | ZNF638 | S636 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15149 | PLEC | S584 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15365 | PCBP1 | S111 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S111 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15746 | MYLK | S343 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16594 | TAF9 | S181 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
| Q3ZCM7 | TUBB8 | S75 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q5H9L2 | TCEAL5 | S127 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
| Q659C4 | LARP1B | S335 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q6IPX3 | TCEAL6 | S121 | ochoa | Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) | May be involved in transcriptional regulation. |
| Q8IX01 | SUGP2 | S772 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q969E4 | TCEAL3 | S121 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q969G9 | NKD1 | S22 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q969X1 | TMBIM1 | S83 | ochoa | Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) | Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. |
| Q96G23 | CERS2 | S248 | psp | Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297) | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity). {ECO:0000250|UniProtKB:Q924Z4, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:19728861, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}. |
| Q96HA1 | POM121 | S714 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q9BSF0 | C2orf88 | S66 | ochoa|psp | Small membrane A-kinase anchor protein (Small membrane AKAP) (smAKAP) | Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane. {ECO:0000269|PubMed:23115245}. |
| Q9BUF5 | TUBB6 | S75 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S75 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9H2J7 | SLC6A15 | S648 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9NQS7 | INCENP | S214 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NW82 | WDR70 | S616 | ochoa | WD repeat-containing protein 70 | None |
| Q9UKV3 | ACIN1 | S700 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UQB8 | BAIAP2 | S311 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2H0 | DLGAP4 | S651 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2W1 | THRAP3 | S336 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| P07900 | HSP90AA1 | S164 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S159 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P13667 | PDIA4 | S383 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| Q14568 | HSP90AA2P | S164 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| P31948 | STIP1 | S459 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P21333 | FLNA | S732 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P05187 | ALPP | S192 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P10696 | ALPG | S189 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P09923 | ALPI | S189 | Sugiyama | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| Q96RE7 | NACC1 | S175 | Sugiyama | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q9UK32 | RPS6KA6 | S560 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| P55084 | HADHB | S284 | Sugiyama | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:29915090, PubMed:30850536, PubMed:8135828). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828). {ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.538414e-13 | 12.123 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.681211e-12 | 11.774 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.877321e-12 | 11.005 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.343659e-11 | 10.872 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.795675e-11 | 10.746 |
| R-HSA-9646399 | Aggrephagy | 4.232903e-11 | 10.373 |
| R-HSA-69275 | G2/M Transition | 9.725809e-11 | 10.012 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.085460e-10 | 9.964 |
| R-HSA-437239 | Recycling pathway of L1 | 1.448300e-10 | 9.839 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.996153e-10 | 9.700 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.126963e-10 | 9.290 |
| R-HSA-190861 | Gap junction assembly | 7.226393e-10 | 9.141 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.686071e-09 | 8.773 |
| R-HSA-68877 | Mitotic Prometaphase | 2.180907e-09 | 8.661 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.448576e-09 | 8.611 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.285928e-09 | 8.483 |
| R-HSA-190828 | Gap junction trafficking | 3.673705e-09 | 8.435 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.052364e-09 | 8.392 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.276160e-09 | 8.369 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.949591e-09 | 8.305 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 5.384677e-09 | 8.269 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.555555e-09 | 8.255 |
| R-HSA-373760 | L1CAM interactions | 6.077426e-09 | 8.216 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.867069e-09 | 8.163 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 8.390930e-09 | 8.076 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.084258e-08 | 7.965 |
| R-HSA-9663891 | Selective autophagy | 1.173947e-08 | 7.930 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.355537e-08 | 7.868 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.700990e-08 | 7.769 |
| R-HSA-68886 | M Phase | 1.886320e-08 | 7.724 |
| R-HSA-983189 | Kinesins | 2.274346e-08 | 7.643 |
| R-HSA-5617833 | Cilium Assembly | 2.645583e-08 | 7.577 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.864208e-08 | 7.543 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.769573e-08 | 7.424 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.256491e-08 | 7.204 |
| R-HSA-9612973 | Autophagy | 7.208150e-08 | 7.142 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.402239e-08 | 7.131 |
| R-HSA-68882 | Mitotic Anaphase | 8.132471e-08 | 7.090 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.454844e-08 | 7.073 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.051080e-07 | 6.978 |
| R-HSA-9833482 | PKR-mediated signaling | 1.291043e-07 | 6.889 |
| R-HSA-5620924 | Intraflagellar transport | 1.916607e-07 | 6.717 |
| R-HSA-9609690 | HCMV Early Events | 4.206173e-07 | 6.376 |
| R-HSA-1640170 | Cell Cycle | 4.624109e-07 | 6.335 |
| R-HSA-1632852 | Macroautophagy | 4.719944e-07 | 6.326 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.753399e-07 | 6.323 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.753399e-07 | 6.323 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.196577e-06 | 5.658 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.419749e-06 | 5.616 |
| R-HSA-9609646 | HCMV Infection | 2.706460e-06 | 5.568 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.001381e-06 | 5.398 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.245593e-06 | 5.372 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.216685e-06 | 5.283 |
| R-HSA-422475 | Axon guidance | 5.651957e-06 | 5.248 |
| R-HSA-391251 | Protein folding | 5.984837e-06 | 5.223 |
| R-HSA-71384 | Ethanol oxidation | 7.647165e-06 | 5.116 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.913745e-06 | 5.102 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.081681e-06 | 5.092 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.640555e-06 | 5.016 |
| R-HSA-913531 | Interferon Signaling | 9.902245e-06 | 5.004 |
| R-HSA-9675108 | Nervous system development | 1.065841e-05 | 4.972 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.588896e-05 | 4.799 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.588896e-05 | 4.799 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.934614e-05 | 4.713 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.273191e-05 | 4.643 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.969419e-05 | 4.527 |
| R-HSA-380287 | Centrosome maturation | 3.332163e-05 | 4.477 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.160124e-05 | 4.287 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.409797e-05 | 4.267 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.155126e-05 | 4.211 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.624963e-05 | 4.118 |
| R-HSA-9824446 | Viral Infection Pathways | 1.038369e-04 | 3.984 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.234398e-04 | 3.909 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.303100e-04 | 3.638 |
| R-HSA-112316 | Neuronal System | 2.676307e-04 | 3.572 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.279470e-04 | 3.484 |
| R-HSA-2262752 | Cellular responses to stress | 4.895489e-04 | 3.310 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 9.055157e-04 | 3.043 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.296646e-03 | 2.887 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.420174e-03 | 2.848 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.517497e-03 | 2.819 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.402846e-03 | 2.619 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.462147e-03 | 2.609 |
| R-HSA-5663205 | Infectious disease | 2.400249e-03 | 2.620 |
| R-HSA-168256 | Immune System | 2.892024e-03 | 2.539 |
| R-HSA-3371556 | Cellular response to heat stress | 2.917186e-03 | 2.535 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.942386e-03 | 2.531 |
| R-HSA-72172 | mRNA Splicing | 2.979779e-03 | 2.526 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.144018e-03 | 2.503 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.187488e-03 | 2.497 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.187488e-03 | 2.497 |
| R-HSA-373755 | Semaphorin interactions | 3.764389e-03 | 2.424 |
| R-HSA-1266738 | Developmental Biology | 3.926363e-03 | 2.406 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 4.618895e-03 | 2.335 |
| R-HSA-156711 | Polo-like kinase mediated events | 4.618895e-03 | 2.335 |
| R-HSA-6798695 | Neutrophil degranulation | 4.751905e-03 | 2.323 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.308911e-03 | 2.275 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.419919e-03 | 2.266 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.288534e-03 | 2.201 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 6.294442e-03 | 2.201 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.231726e-03 | 2.141 |
| R-HSA-109582 | Hemostasis | 8.018959e-03 | 2.096 |
| R-HSA-199991 | Membrane Trafficking | 8.454120e-03 | 2.073 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.091285e-02 | 1.962 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.149550e-02 | 1.939 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.149550e-02 | 1.939 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.270098e-02 | 1.896 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.270098e-02 | 1.896 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.270098e-02 | 1.896 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.096696e-02 | 1.960 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.209159e-02 | 1.918 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.618665e-03 | 2.017 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.715695e-03 | 2.013 |
| R-HSA-9679506 | SARS-CoV Infections | 1.256255e-02 | 1.901 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.332357e-02 | 1.875 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.332357e-02 | 1.875 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.395921e-02 | 1.855 |
| R-HSA-5365859 | RA biosynthesis pathway | 1.395921e-02 | 1.855 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.460781e-02 | 1.835 |
| R-HSA-3371511 | HSF1 activation | 1.526922e-02 | 1.816 |
| R-HSA-211000 | Gene Silencing by RNA | 1.529487e-02 | 1.815 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.594334e-02 | 1.797 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.663004e-02 | 1.779 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.663004e-02 | 1.779 |
| R-HSA-5357801 | Programmed Cell Death | 1.684370e-02 | 1.774 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 1.723989e-02 | 1.763 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 1.723989e-02 | 1.763 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 1.723989e-02 | 1.763 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 1.723989e-02 | 1.763 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 1.723989e-02 | 1.763 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 1.723989e-02 | 1.763 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 1.723989e-02 | 1.763 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 1.723989e-02 | 1.763 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 1.723989e-02 | 1.763 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 1.723989e-02 | 1.763 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 1.723989e-02 | 1.763 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 1.723989e-02 | 1.763 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.732920e-02 | 1.761 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.732920e-02 | 1.761 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.732920e-02 | 1.761 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.804071e-02 | 1.744 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.804071e-02 | 1.744 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.804071e-02 | 1.744 |
| R-HSA-3371568 | Attenuation phase | 1.804071e-02 | 1.744 |
| R-HSA-397014 | Muscle contraction | 1.861742e-02 | 1.730 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.876445e-02 | 1.727 |
| R-HSA-68875 | Mitotic Prophase | 2.086073e-02 | 1.681 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.256256e-02 | 1.647 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.309629e-02 | 1.636 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.335726e-02 | 1.632 |
| R-HSA-75153 | Apoptotic execution phase | 2.335726e-02 | 1.632 |
| R-HSA-446107 | Type I hemidesmosome assembly | 4.670752e-02 | 1.331 |
| R-HSA-444257 | RSK activation | 4.670752e-02 | 1.331 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.418673e-02 | 1.466 |
| R-HSA-176417 | Phosphorylation of Emi1 | 3.418673e-02 | 1.466 |
| R-HSA-191859 | snRNP Assembly | 3.468896e-02 | 1.460 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.468896e-02 | 1.460 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.658870e-02 | 1.437 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.178925e-02 | 1.498 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 3.837824e-02 | 1.416 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.750005e-02 | 1.561 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.987547e-02 | 1.399 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.771948e-02 | 1.321 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.281205e-02 | 1.484 |
| R-HSA-447043 | Neurofascin interactions | 3.837824e-02 | 1.416 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.755337e-02 | 1.425 |
| R-HSA-162587 | HIV Life Cycle | 4.102550e-02 | 1.387 |
| R-HSA-5218859 | Regulated Necrosis | 4.354246e-02 | 1.361 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 3.563386e-02 | 1.448 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.050543e-02 | 1.392 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.836169e-02 | 1.547 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 5.084545e-02 | 1.294 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 5.084545e-02 | 1.294 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.094465e-02 | 1.293 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.203681e-02 | 1.284 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.212053e-02 | 1.283 |
| R-HSA-168255 | Influenza Infection | 5.543593e-02 | 1.256 |
| R-HSA-597592 | Post-translational protein modification | 5.756483e-02 | 1.240 |
| R-HSA-192905 | vRNP Assembly | 5.906827e-02 | 1.229 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 6.315331e-02 | 1.200 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.340547e-02 | 1.198 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.340547e-02 | 1.198 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.577215e-02 | 1.182 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 6.722087e-02 | 1.172 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 6.722087e-02 | 1.172 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 6.722087e-02 | 1.172 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 6.722087e-02 | 1.172 |
| R-HSA-8983711 | OAS antiviral response | 6.722087e-02 | 1.172 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 7.127101e-02 | 1.147 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.304584e-02 | 1.136 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 7.530382e-02 | 1.123 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 7.530382e-02 | 1.123 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 7.530382e-02 | 1.123 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 7.530382e-02 | 1.123 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.712214e-02 | 1.113 |
| R-HSA-8953854 | Metabolism of RNA | 7.810167e-02 | 1.107 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.929641e-02 | 1.101 |
| R-HSA-176412 | Phosphorylation of the APC/C | 8.331773e-02 | 1.079 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.441349e-02 | 1.074 |
| R-HSA-70171 | Glycolysis | 8.441349e-02 | 1.074 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.565705e-02 | 1.067 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.700921e-02 | 1.060 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 8.729897e-02 | 1.059 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 8.729897e-02 | 1.059 |
| R-HSA-211859 | Biological oxidations | 8.804005e-02 | 1.055 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 9.094756e-02 | 1.041 |
| R-HSA-1280218 | Adaptive Immune System | 9.118940e-02 | 1.040 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 9.126317e-02 | 1.040 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 9.126317e-02 | 1.040 |
| R-HSA-162906 | HIV Infection | 9.292716e-02 | 1.032 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 9.521039e-02 | 1.021 |
| R-HSA-3928664 | Ephrin signaling | 9.521039e-02 | 1.021 |
| R-HSA-844456 | The NLRP3 inflammasome | 9.914071e-02 | 1.004 |
| R-HSA-162582 | Signal Transduction | 1.005471e-01 | 0.998 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.016985e-01 | 0.993 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.030542e-01 | 0.987 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.069509e-01 | 0.971 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.069509e-01 | 0.971 |
| R-HSA-2161541 | Abacavir metabolism | 1.069509e-01 | 0.971 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.085892e-01 | 0.964 |
| R-HSA-70326 | Glucose metabolism | 1.113799e-01 | 0.953 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.212931e-01 | 0.916 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.223717e-01 | 0.912 |
| R-HSA-194138 | Signaling by VEGF | 1.241649e-01 | 0.906 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.261857e-01 | 0.899 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 1.261857e-01 | 0.899 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.299833e-01 | 0.886 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.299833e-01 | 0.886 |
| R-HSA-2161522 | Abacavir ADME | 1.299833e-01 | 0.886 |
| R-HSA-168249 | Innate Immune System | 1.301282e-01 | 0.886 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.337647e-01 | 0.874 |
| R-HSA-9843745 | Adipogenesis | 1.343436e-01 | 0.872 |
| R-HSA-622312 | Inflammasomes | 1.375299e-01 | 0.862 |
| R-HSA-446728 | Cell junction organization | 1.403043e-01 | 0.853 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.412789e-01 | 0.850 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.432146e-01 | 0.844 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.447052e-01 | 0.840 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.450119e-01 | 0.839 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.450119e-01 | 0.839 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 1.450119e-01 | 0.839 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.487289e-01 | 0.828 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.561152e-01 | 0.807 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.561152e-01 | 0.807 |
| R-HSA-390522 | Striated Muscle Contraction | 1.597846e-01 | 0.796 |
| R-HSA-203615 | eNOS activation | 1.634382e-01 | 0.787 |
| R-HSA-1643685 | Disease | 1.655696e-01 | 0.781 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.658992e-01 | 0.780 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.670763e-01 | 0.777 |
| R-HSA-9610379 | HCMV Late Events | 1.766951e-01 | 0.753 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.778970e-01 | 0.750 |
| R-HSA-1500931 | Cell-Cell communication | 1.799018e-01 | 0.745 |
| R-HSA-109581 | Apoptosis | 1.844747e-01 | 0.734 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.850337e-01 | 0.733 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.885791e-01 | 0.725 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.885791e-01 | 0.725 |
| R-HSA-167161 | HIV Transcription Initiation | 1.921093e-01 | 0.716 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.921093e-01 | 0.716 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.921093e-01 | 0.716 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.921093e-01 | 0.716 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.921093e-01 | 0.716 |
| R-HSA-5619102 | SLC transporter disorders | 1.923044e-01 | 0.716 |
| R-HSA-72306 | tRNA processing | 1.986005e-01 | 0.702 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.991244e-01 | 0.701 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.060794e-01 | 0.686 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 2.060794e-01 | 0.686 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.095346e-01 | 0.679 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 2.095346e-01 | 0.679 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 2.095346e-01 | 0.679 |
| R-HSA-72187 | mRNA 3'-end processing | 2.299564e-01 | 0.638 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.299564e-01 | 0.638 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.299564e-01 | 0.638 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.333091e-01 | 0.632 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.336179e-01 | 0.631 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.432810e-01 | 0.614 |
| R-HSA-8935690 | Digestion | 2.432810e-01 | 0.614 |
| R-HSA-1483166 | Synthesis of PA | 2.465765e-01 | 0.608 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 2.512862e-01 | 0.600 |
| R-HSA-392499 | Metabolism of proteins | 2.516609e-01 | 0.599 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.531252e-01 | 0.597 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 2.531252e-01 | 0.597 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.563784e-01 | 0.591 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 2.563784e-01 | 0.591 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.596177e-01 | 0.586 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.628430e-01 | 0.580 |
| R-HSA-8963743 | Digestion and absorption | 2.660545e-01 | 0.575 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.689981e-01 | 0.570 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 2.692523e-01 | 0.570 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.692523e-01 | 0.570 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 2.787632e-01 | 0.555 |
| R-HSA-167172 | Transcription of the HIV genome | 2.819064e-01 | 0.550 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.912550e-01 | 0.536 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.912550e-01 | 0.536 |
| R-HSA-8978934 | Metabolism of cofactors | 2.912550e-01 | 0.536 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.004836e-01 | 0.522 |
| R-HSA-8939211 | ESR-mediated signaling | 3.075962e-01 | 0.512 |
| R-HSA-449147 | Signaling by Interleukins | 3.089647e-01 | 0.510 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.235904e-01 | 0.490 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.333195e-01 | 0.477 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.391243e-01 | 0.470 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.391243e-01 | 0.470 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.410823e-01 | 0.467 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.618493e-01 | 0.441 |
| R-HSA-1474290 | Collagen formation | 3.646352e-01 | 0.438 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 3.674091e-01 | 0.435 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.701710e-01 | 0.432 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.771935e-01 | 0.423 |
| R-HSA-9658195 | Leishmania infection | 3.771935e-01 | 0.423 |
| R-HSA-3214847 | HATs acetylate histones | 3.811005e-01 | 0.419 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.864950e-01 | 0.413 |
| R-HSA-1483257 | Phospholipid metabolism | 3.987933e-01 | 0.399 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.024017e-01 | 0.395 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.501386e-01 | 0.347 |
| R-HSA-114608 | Platelet degranulation | 4.620631e-01 | 0.335 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.783303e-01 | 0.320 |
| R-HSA-9664407 | Parasite infection | 4.963282e-01 | 0.304 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.963282e-01 | 0.304 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.963282e-01 | 0.304 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 5.200796e-01 | 0.284 |
| R-HSA-1989781 | PPARA activates gene expression | 5.305073e-01 | 0.275 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.346156e-01 | 0.272 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.362156e-01 | 0.271 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.366565e-01 | 0.270 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.407117e-01 | 0.267 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.719187e-01 | 0.243 |
| R-HSA-2559583 | Cellular Senescence | 5.812352e-01 | 0.236 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.165861e-01 | 0.210 |
| R-HSA-428157 | Sphingolipid metabolism | 6.182298e-01 | 0.209 |
| R-HSA-9748784 | Drug ADME | 6.473614e-01 | 0.189 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.714094e-01 | 0.173 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.757350e-01 | 0.170 |
| R-HSA-4839726 | Chromatin organization | 6.924829e-01 | 0.160 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.246834e-01 | 0.140 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.674716e-01 | 0.115 |
| R-HSA-1474244 | Extracellular matrix organization | 7.861921e-01 | 0.104 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.153844e-01 | 0.089 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.413496e-01 | 0.075 |
| R-HSA-8978868 | Fatty acid metabolism | 8.482765e-01 | 0.071 |
| R-HSA-72766 | Translation | 8.624833e-01 | 0.064 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.829538e-01 | 0.054 |
| R-HSA-556833 | Metabolism of lipids | 9.035096e-01 | 0.044 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.064876e-01 | 0.043 |
| R-HSA-1430728 | Metabolism | 9.193505e-01 | 0.037 |
| R-HSA-74160 | Gene expression (Transcription) | 9.438436e-01 | 0.025 |
| R-HSA-382551 | Transport of small molecules | 9.888590e-01 | 0.005 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.964757e-01 | 0.002 |
| R-HSA-212436 | Generic Transcription Pathway | 9.992499e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.764 | 0.181 | 2 | 0.733 |
DSTYK |
0.750 | 0.147 | 2 | 0.791 |
FAM20C |
0.747 | 0.223 | 2 | 0.655 |
IKKE |
0.747 | 0.043 | 1 | 0.670 |
TBK1 |
0.747 | 0.029 | 1 | 0.665 |
CDC7 |
0.747 | 0.030 | 1 | 0.678 |
ERK5 |
0.747 | 0.094 | 1 | 0.668 |
MOS |
0.746 | 0.118 | 1 | 0.685 |
PRKD1 |
0.746 | 0.087 | -3 | 0.627 |
PRPK |
0.745 | 0.035 | -1 | 0.763 |
ULK2 |
0.744 | 0.028 | 2 | 0.681 |
IKKB |
0.744 | -0.002 | -2 | 0.672 |
NLK |
0.743 | 0.074 | 1 | 0.715 |
KIS |
0.742 | 0.085 | 1 | 0.622 |
CLK3 |
0.742 | 0.073 | 1 | 0.675 |
MLK1 |
0.741 | 0.121 | 2 | 0.754 |
CDK8 |
0.741 | 0.095 | 1 | 0.620 |
IKKA |
0.741 | 0.051 | -2 | 0.663 |
GCN2 |
0.740 | -0.039 | 2 | 0.683 |
CAMK2G |
0.740 | 0.020 | 2 | 0.682 |
RAF1 |
0.740 | 0.018 | 1 | 0.701 |
NEK6 |
0.740 | 0.051 | -2 | 0.788 |
PDHK4 |
0.739 | -0.064 | 1 | 0.711 |
MTOR |
0.739 | -0.047 | 1 | 0.665 |
GRK1 |
0.738 | 0.084 | -2 | 0.699 |
PRKD2 |
0.738 | 0.040 | -3 | 0.590 |
PDHK1 |
0.738 | -0.004 | 1 | 0.726 |
MST4 |
0.737 | 0.064 | 2 | 0.781 |
PIM3 |
0.737 | 0.003 | -3 | 0.640 |
MLK3 |
0.737 | 0.135 | 2 | 0.740 |
TGFBR2 |
0.736 | 0.019 | -2 | 0.756 |
NEK7 |
0.736 | 0.001 | -3 | 0.661 |
CAMK2D |
0.735 | 0.032 | -3 | 0.651 |
NDR2 |
0.735 | -0.030 | -3 | 0.656 |
BCKDK |
0.735 | -0.002 | -1 | 0.663 |
CDK19 |
0.735 | 0.090 | 1 | 0.590 |
PKN3 |
0.735 | 0.024 | -3 | 0.625 |
MLK4 |
0.734 | 0.157 | 2 | 0.712 |
GRK6 |
0.734 | 0.083 | 1 | 0.682 |
CDKL5 |
0.734 | 0.057 | -3 | 0.584 |
BMPR1B |
0.734 | 0.133 | 1 | 0.634 |
ATR |
0.733 | -0.007 | 1 | 0.682 |
BMPR2 |
0.733 | -0.049 | -2 | 0.819 |
CAMK2B |
0.733 | 0.077 | 2 | 0.654 |
CHAK2 |
0.733 | 0.026 | -1 | 0.660 |
GRK4 |
0.733 | 0.041 | -2 | 0.749 |
GRK5 |
0.733 | 0.018 | -3 | 0.720 |
HIPK4 |
0.733 | 0.039 | 1 | 0.644 |
MLK2 |
0.733 | 0.088 | 2 | 0.722 |
MARK4 |
0.732 | -0.002 | 4 | 0.736 |
CAMK1B |
0.732 | -0.036 | -3 | 0.676 |
ULK1 |
0.732 | -0.051 | -3 | 0.660 |
NEK9 |
0.732 | 0.053 | 2 | 0.751 |
PKCD |
0.732 | 0.064 | 2 | 0.743 |
CDKL1 |
0.731 | 0.011 | -3 | 0.591 |
RSK2 |
0.731 | -0.003 | -3 | 0.570 |
NIK |
0.730 | 0.011 | -3 | 0.705 |
CDK18 |
0.730 | 0.117 | 1 | 0.530 |
ATM |
0.730 | 0.050 | 1 | 0.628 |
TGFBR1 |
0.730 | 0.092 | -2 | 0.743 |
PKN2 |
0.729 | 0.031 | -3 | 0.660 |
ICK |
0.728 | 0.054 | -3 | 0.631 |
P38B |
0.728 | 0.125 | 1 | 0.575 |
CAMK2A |
0.728 | 0.045 | 2 | 0.661 |
RIPK3 |
0.727 | -0.035 | 3 | 0.707 |
CDK7 |
0.727 | 0.059 | 1 | 0.599 |
TTBK2 |
0.727 | -0.032 | 2 | 0.663 |
RSK3 |
0.727 | -0.027 | -3 | 0.557 |
CDK5 |
0.727 | 0.106 | 1 | 0.597 |
SKMLCK |
0.727 | -0.007 | -2 | 0.744 |
CDK1 |
0.727 | 0.094 | 1 | 0.556 |
P90RSK |
0.727 | -0.030 | -3 | 0.565 |
PIM1 |
0.726 | 0.001 | -3 | 0.602 |
P38A |
0.726 | 0.112 | 1 | 0.616 |
PKCA |
0.726 | 0.092 | 2 | 0.730 |
P70S6KB |
0.726 | -0.015 | -3 | 0.604 |
YSK4 |
0.726 | 0.106 | 1 | 0.661 |
MAPKAPK2 |
0.726 | 0.007 | -3 | 0.544 |
PKCB |
0.726 | 0.076 | 2 | 0.734 |
NUAK2 |
0.725 | -0.031 | -3 | 0.657 |
P38G |
0.725 | 0.101 | 1 | 0.504 |
JNK2 |
0.725 | 0.091 | 1 | 0.574 |
WNK1 |
0.725 | -0.042 | -2 | 0.766 |
ANKRD3 |
0.724 | 0.049 | 1 | 0.722 |
MAPKAPK3 |
0.724 | -0.037 | -3 | 0.589 |
P38D |
0.724 | 0.115 | 1 | 0.528 |
PKCG |
0.724 | 0.054 | 2 | 0.730 |
ERK1 |
0.724 | 0.096 | 1 | 0.569 |
CDK17 |
0.724 | 0.095 | 1 | 0.497 |
NDR1 |
0.723 | -0.069 | -3 | 0.646 |
PHKG1 |
0.723 | 0.009 | -3 | 0.646 |
GRK7 |
0.723 | 0.078 | 1 | 0.588 |
WNK3 |
0.723 | -0.136 | 1 | 0.676 |
MASTL |
0.723 | -0.133 | -2 | 0.775 |
LATS1 |
0.723 | 0.079 | -3 | 0.648 |
ALK4 |
0.722 | 0.023 | -2 | 0.769 |
CAMLCK |
0.722 | -0.055 | -2 | 0.754 |
PLK1 |
0.722 | 0.027 | -2 | 0.743 |
CK1E |
0.721 | 0.117 | -3 | 0.586 |
PLK3 |
0.721 | 0.034 | 2 | 0.633 |
CK2A2 |
0.721 | 0.175 | 1 | 0.601 |
DAPK2 |
0.721 | -0.059 | -3 | 0.672 |
SIK |
0.720 | -0.018 | -3 | 0.575 |
DLK |
0.720 | -0.020 | 1 | 0.710 |
AMPKA1 |
0.720 | -0.048 | -3 | 0.678 |
LATS2 |
0.720 | -0.063 | -5 | 0.567 |
ACVR2A |
0.720 | 0.060 | -2 | 0.751 |
JNK3 |
0.720 | 0.068 | 1 | 0.589 |
HUNK |
0.720 | -0.123 | 2 | 0.655 |
DYRK2 |
0.720 | 0.037 | 1 | 0.611 |
ACVR2B |
0.720 | 0.062 | -2 | 0.750 |
PRKD3 |
0.719 | -0.011 | -3 | 0.551 |
QSK |
0.719 | -0.013 | 4 | 0.719 |
CDK16 |
0.719 | 0.107 | 1 | 0.499 |
ALK2 |
0.718 | 0.064 | -2 | 0.763 |
TSSK2 |
0.718 | -0.014 | -5 | 0.687 |
BMPR1A |
0.718 | 0.091 | 1 | 0.628 |
CDK13 |
0.718 | 0.035 | 1 | 0.571 |
MARK2 |
0.718 | -0.004 | 4 | 0.671 |
NIM1 |
0.718 | -0.087 | 3 | 0.734 |
DNAPK |
0.718 | 0.015 | 1 | 0.629 |
SRPK1 |
0.717 | -0.036 | -3 | 0.545 |
CDK3 |
0.717 | 0.092 | 1 | 0.508 |
TSSK1 |
0.717 | -0.022 | -3 | 0.695 |
RSK4 |
0.717 | -0.009 | -3 | 0.542 |
ZAK |
0.717 | 0.094 | 1 | 0.702 |
CK1D |
0.717 | 0.124 | -3 | 0.554 |
PRP4 |
0.716 | 0.068 | -3 | 0.613 |
PKACG |
0.716 | -0.058 | -2 | 0.623 |
IRE2 |
0.716 | -0.033 | 2 | 0.673 |
MARK3 |
0.716 | -0.002 | 4 | 0.684 |
MEKK1 |
0.715 | 0.087 | 1 | 0.714 |
NEK2 |
0.715 | -0.000 | 2 | 0.749 |
ERK7 |
0.715 | 0.177 | 2 | 0.663 |
CK1A2 |
0.715 | 0.122 | -3 | 0.547 |
CDK2 |
0.715 | 0.047 | 1 | 0.619 |
PAK1 |
0.714 | -0.043 | -2 | 0.666 |
PKCH |
0.714 | 0.011 | 2 | 0.703 |
QIK |
0.714 | -0.071 | -3 | 0.647 |
HIPK2 |
0.714 | 0.058 | 1 | 0.534 |
PKR |
0.714 | 0.014 | 1 | 0.665 |
CHAK1 |
0.713 | -0.067 | 2 | 0.691 |
AMPKA2 |
0.713 | -0.064 | -3 | 0.644 |
CK1G1 |
0.713 | 0.085 | -3 | 0.560 |
AURC |
0.713 | -0.025 | -2 | 0.546 |
SRPK2 |
0.713 | -0.039 | -3 | 0.469 |
MSK2 |
0.713 | -0.065 | -3 | 0.535 |
MST3 |
0.713 | 0.114 | 2 | 0.772 |
CDK12 |
0.713 | 0.038 | 1 | 0.561 |
PLK4 |
0.713 | -0.050 | 2 | 0.490 |
PAK6 |
0.712 | -0.001 | -2 | 0.606 |
TLK2 |
0.712 | -0.036 | 1 | 0.662 |
MNK2 |
0.712 | -0.034 | -2 | 0.672 |
PKCZ |
0.712 | 0.001 | 2 | 0.741 |
IRE1 |
0.712 | -0.083 | 1 | 0.600 |
MARK1 |
0.712 | -0.019 | 4 | 0.700 |
MEK1 |
0.711 | -0.067 | 2 | 0.669 |
TAO3 |
0.711 | 0.078 | 1 | 0.676 |
DRAK1 |
0.711 | -0.009 | 1 | 0.632 |
PAK3 |
0.711 | -0.079 | -2 | 0.665 |
GRK2 |
0.711 | 0.009 | -2 | 0.633 |
VRK2 |
0.711 | -0.071 | 1 | 0.722 |
HIPK1 |
0.711 | 0.040 | 1 | 0.615 |
BRSK1 |
0.711 | -0.061 | -3 | 0.600 |
SMG1 |
0.711 | -0.053 | 1 | 0.641 |
MELK |
0.710 | -0.068 | -3 | 0.625 |
SRPK3 |
0.710 | -0.044 | -3 | 0.514 |
CDK14 |
0.710 | 0.070 | 1 | 0.566 |
ERK2 |
0.710 | 0.040 | 1 | 0.584 |
AURA |
0.710 | -0.010 | -2 | 0.514 |
SGK3 |
0.710 | -0.019 | -3 | 0.566 |
CK2A1 |
0.709 | 0.149 | 1 | 0.591 |
PKACB |
0.709 | -0.020 | -2 | 0.543 |
CAMK4 |
0.709 | -0.105 | -3 | 0.650 |
CLK4 |
0.708 | -0.027 | -3 | 0.577 |
CDK9 |
0.708 | 0.014 | 1 | 0.580 |
DYRK1A |
0.707 | 0.020 | 1 | 0.642 |
BRAF |
0.707 | 0.028 | -4 | 0.631 |
CLK2 |
0.707 | 0.010 | -3 | 0.563 |
MNK1 |
0.707 | -0.045 | -2 | 0.688 |
CLK1 |
0.706 | -0.021 | -3 | 0.561 |
PKG2 |
0.706 | -0.033 | -2 | 0.553 |
HRI |
0.706 | -0.058 | -2 | 0.808 |
RIPK1 |
0.706 | -0.168 | 1 | 0.647 |
PERK |
0.706 | -0.051 | -2 | 0.817 |
NUAK1 |
0.706 | -0.096 | -3 | 0.606 |
CHK1 |
0.706 | -0.048 | -3 | 0.653 |
BRSK2 |
0.706 | -0.104 | -3 | 0.636 |
MEKK3 |
0.706 | -0.026 | 1 | 0.693 |
PLK2 |
0.706 | 0.068 | -3 | 0.663 |
NEK5 |
0.705 | -0.003 | 1 | 0.667 |
DYRK4 |
0.705 | 0.038 | 1 | 0.560 |
TTBK1 |
0.705 | -0.074 | 2 | 0.581 |
MEKK2 |
0.705 | 0.019 | 2 | 0.690 |
PHKG2 |
0.705 | -0.036 | -3 | 0.630 |
GRK3 |
0.705 | 0.029 | -2 | 0.580 |
MSK1 |
0.704 | -0.053 | -3 | 0.545 |
MST2 |
0.704 | 0.136 | 1 | 0.701 |
PKCT |
0.704 | -0.005 | 2 | 0.705 |
HIPK3 |
0.703 | 0.004 | 1 | 0.633 |
JNK1 |
0.703 | 0.056 | 1 | 0.547 |
GSK3A |
0.703 | 0.033 | 4 | 0.373 |
TLK1 |
0.703 | -0.005 | -2 | 0.741 |
PIM2 |
0.703 | -0.035 | -3 | 0.552 |
PAK2 |
0.703 | -0.097 | -2 | 0.663 |
AKT2 |
0.703 | -0.044 | -3 | 0.498 |
MYLK4 |
0.702 | -0.065 | -2 | 0.650 |
CDK10 |
0.702 | 0.057 | 1 | 0.552 |
AURB |
0.702 | -0.051 | -2 | 0.541 |
MEK5 |
0.701 | -0.102 | 2 | 0.693 |
GSK3B |
0.701 | -0.000 | 4 | 0.366 |
MAPKAPK5 |
0.700 | -0.127 | -3 | 0.500 |
DYRK1B |
0.700 | 0.013 | 1 | 0.569 |
PRKX |
0.700 | -0.030 | -3 | 0.507 |
TAO2 |
0.700 | 0.017 | 2 | 0.772 |
SSTK |
0.697 | -0.050 | 4 | 0.720 |
AKT1 |
0.697 | -0.034 | -3 | 0.518 |
IRAK4 |
0.697 | -0.082 | 1 | 0.627 |
WNK4 |
0.697 | -0.109 | -2 | 0.782 |
P70S6K |
0.697 | -0.069 | -3 | 0.505 |
DCAMKL1 |
0.696 | -0.082 | -3 | 0.606 |
CAMKK2 |
0.696 | -0.011 | -2 | 0.751 |
NEK8 |
0.696 | -0.029 | 2 | 0.737 |
CAMK1G |
0.696 | -0.095 | -3 | 0.567 |
PINK1 |
0.696 | -0.131 | 1 | 0.633 |
CDK6 |
0.696 | 0.053 | 1 | 0.554 |
NEK11 |
0.696 | -0.064 | 1 | 0.691 |
MAK |
0.696 | 0.101 | -2 | 0.791 |
MPSK1 |
0.695 | 0.000 | 1 | 0.570 |
EEF2K |
0.694 | 0.069 | 3 | 0.716 |
GCK |
0.694 | 0.045 | 1 | 0.690 |
PKCI |
0.694 | -0.013 | 2 | 0.735 |
DYRK3 |
0.694 | -0.016 | 1 | 0.625 |
SNRK |
0.694 | -0.195 | 2 | 0.542 |
PKCE |
0.694 | 0.012 | 2 | 0.728 |
CAMKK1 |
0.693 | -0.043 | -2 | 0.734 |
PASK |
0.693 | -0.041 | -3 | 0.653 |
MINK |
0.692 | 0.044 | 1 | 0.687 |
TNIK |
0.692 | 0.036 | 3 | 0.744 |
NEK4 |
0.692 | -0.026 | 1 | 0.669 |
CAMK1D |
0.692 | -0.056 | -3 | 0.509 |
PAK4 |
0.692 | -0.039 | -2 | 0.558 |
HGK |
0.692 | 0.013 | 3 | 0.735 |
SMMLCK |
0.692 | -0.076 | -3 | 0.622 |
MST1 |
0.692 | 0.053 | 1 | 0.688 |
PKN1 |
0.692 | -0.021 | -3 | 0.529 |
PAK5 |
0.691 | -0.054 | -2 | 0.548 |
PKACA |
0.691 | -0.050 | -2 | 0.501 |
DCAMKL2 |
0.690 | -0.088 | -3 | 0.633 |
MAP3K15 |
0.690 | -0.016 | 1 | 0.677 |
CDK4 |
0.690 | 0.040 | 1 | 0.547 |
CK1A |
0.690 | 0.096 | -3 | 0.486 |
TAK1 |
0.689 | 0.036 | 1 | 0.685 |
HPK1 |
0.688 | 0.021 | 1 | 0.681 |
YSK1 |
0.688 | 0.044 | 2 | 0.758 |
IRAK1 |
0.688 | -0.171 | -1 | 0.589 |
MOK |
0.687 | 0.048 | 1 | 0.592 |
KHS1 |
0.687 | 0.040 | 1 | 0.680 |
PDK1 |
0.686 | -0.101 | 1 | 0.661 |
DAPK3 |
0.686 | -0.047 | -3 | 0.613 |
NEK1 |
0.686 | -0.031 | 1 | 0.650 |
LOK |
0.686 | -0.017 | -2 | 0.705 |
AKT3 |
0.685 | -0.043 | -3 | 0.434 |
LKB1 |
0.684 | -0.108 | -3 | 0.666 |
KHS2 |
0.684 | 0.045 | 1 | 0.689 |
SGK1 |
0.683 | -0.042 | -3 | 0.418 |
MEKK6 |
0.683 | -0.081 | 1 | 0.682 |
BUB1 |
0.683 | 0.021 | -5 | 0.706 |
CAMK1A |
0.683 | -0.049 | -3 | 0.473 |
GAK |
0.683 | -0.078 | 1 | 0.627 |
LRRK2 |
0.682 | -0.068 | 2 | 0.754 |
ROCK2 |
0.682 | -0.016 | -3 | 0.604 |
OSR1 |
0.682 | 0.065 | 2 | 0.679 |
DAPK1 |
0.681 | -0.053 | -3 | 0.595 |
RIPK2 |
0.681 | -0.135 | 1 | 0.669 |
TTK |
0.680 | 0.075 | -2 | 0.765 |
MRCKB |
0.680 | -0.051 | -3 | 0.556 |
NEK3 |
0.679 | -0.043 | 1 | 0.674 |
VRK1 |
0.679 | -0.073 | 2 | 0.687 |
SBK |
0.678 | -0.045 | -3 | 0.390 |
CHK2 |
0.677 | -0.069 | -3 | 0.452 |
SLK |
0.677 | -0.056 | -2 | 0.654 |
PDHK3_TYR |
0.676 | 0.184 | 4 | 0.755 |
MRCKA |
0.676 | -0.062 | -3 | 0.567 |
STK33 |
0.676 | -0.126 | 2 | 0.537 |
MEK2 |
0.676 | -0.159 | 2 | 0.653 |
ALPHAK3 |
0.674 | 0.058 | -1 | 0.781 |
YANK3 |
0.674 | 0.001 | 2 | 0.368 |
TAO1 |
0.674 | -0.006 | 1 | 0.643 |
MYO3A |
0.673 | 0.040 | 1 | 0.657 |
EPHB4 |
0.671 | 0.175 | -1 | 0.801 |
MAP2K4_TYR |
0.670 | 0.117 | -1 | 0.787 |
PBK |
0.670 | -0.086 | 1 | 0.574 |
EPHA6 |
0.670 | 0.157 | -1 | 0.797 |
MYO3B |
0.669 | 0.009 | 2 | 0.768 |
BMPR2_TYR |
0.668 | 0.106 | -1 | 0.787 |
MAP2K6_TYR |
0.668 | 0.113 | -1 | 0.780 |
ASK1 |
0.668 | -0.056 | 1 | 0.661 |
ROCK1 |
0.668 | -0.043 | -3 | 0.571 |
JAK2 |
0.667 | 0.086 | 1 | 0.694 |
PDHK1_TYR |
0.666 | 0.093 | -1 | 0.790 |
TYK2 |
0.665 | 0.056 | 1 | 0.675 |
RET |
0.665 | 0.059 | 1 | 0.676 |
PKMYT1_TYR |
0.665 | 0.009 | 3 | 0.786 |
ABL2 |
0.665 | 0.090 | -1 | 0.746 |
DMPK1 |
0.664 | -0.046 | -3 | 0.581 |
JAK1 |
0.664 | 0.089 | 1 | 0.664 |
PDHK4_TYR |
0.664 | 0.027 | 2 | 0.701 |
PKG1 |
0.664 | -0.094 | -2 | 0.463 |
ROS1 |
0.663 | 0.053 | 3 | 0.707 |
TESK1_TYR |
0.663 | -0.032 | 3 | 0.803 |
CK1G3 |
0.662 | 0.071 | -3 | 0.445 |
MST1R |
0.662 | 0.045 | 3 | 0.755 |
TXK |
0.662 | 0.090 | 1 | 0.715 |
JAK3 |
0.662 | 0.110 | 1 | 0.660 |
MAP2K7_TYR |
0.661 | -0.096 | 2 | 0.709 |
ABL1 |
0.661 | 0.072 | -1 | 0.731 |
EPHB2 |
0.661 | 0.120 | -1 | 0.790 |
INSRR |
0.661 | 0.100 | 3 | 0.706 |
LIMK2_TYR |
0.660 | -0.005 | -3 | 0.720 |
TNNI3K_TYR |
0.660 | 0.127 | 1 | 0.746 |
EPHB1 |
0.660 | 0.088 | 1 | 0.722 |
CRIK |
0.659 | -0.070 | -3 | 0.509 |
BIKE |
0.659 | -0.058 | 1 | 0.506 |
CSF1R |
0.659 | 0.036 | 3 | 0.720 |
STLK3 |
0.658 | -0.057 | 1 | 0.673 |
FER |
0.658 | 0.007 | 1 | 0.705 |
EPHB3 |
0.658 | 0.083 | -1 | 0.778 |
PDGFRB |
0.657 | 0.052 | 3 | 0.728 |
KDR |
0.657 | 0.088 | 3 | 0.704 |
FGFR1 |
0.656 | 0.069 | 3 | 0.722 |
EPHA4 |
0.656 | 0.054 | 2 | 0.632 |
TYRO3 |
0.656 | -0.025 | 3 | 0.722 |
INSR |
0.656 | 0.092 | 3 | 0.688 |
NTRK1 |
0.656 | 0.072 | -1 | 0.795 |
HASPIN |
0.656 | -0.090 | -1 | 0.478 |
FGR |
0.655 | 0.016 | 1 | 0.682 |
ALK |
0.655 | 0.045 | 3 | 0.683 |
BMX |
0.655 | 0.059 | -1 | 0.691 |
FGFR2 |
0.654 | 0.058 | 3 | 0.749 |
LCK |
0.654 | 0.014 | -1 | 0.709 |
ITK |
0.654 | 0.019 | -1 | 0.693 |
NTRK3 |
0.654 | 0.084 | -1 | 0.780 |
LTK |
0.654 | 0.029 | 3 | 0.705 |
MET |
0.654 | 0.060 | 3 | 0.728 |
SRMS |
0.653 | -0.007 | 1 | 0.699 |
PINK1_TYR |
0.653 | -0.160 | 1 | 0.658 |
LIMK1_TYR |
0.653 | -0.105 | 2 | 0.739 |
KIT |
0.652 | 0.029 | 3 | 0.711 |
DDR1 |
0.652 | -0.059 | 4 | 0.678 |
HCK |
0.652 | -0.026 | -1 | 0.711 |
EGFR |
0.652 | 0.078 | 1 | 0.564 |
MERTK |
0.651 | 0.018 | 3 | 0.721 |
FLT3 |
0.651 | 0.008 | 3 | 0.704 |
NTRK2 |
0.651 | 0.041 | 3 | 0.705 |
BLK |
0.650 | 0.015 | -1 | 0.707 |
FLT1 |
0.650 | 0.098 | -1 | 0.829 |
YES1 |
0.650 | -0.044 | -1 | 0.711 |
EPHA3 |
0.650 | 0.047 | 2 | 0.619 |
EPHA7 |
0.650 | 0.056 | 2 | 0.647 |
FGFR4 |
0.650 | 0.087 | -1 | 0.801 |
PTK6 |
0.649 | -0.040 | -1 | 0.678 |
TNK2 |
0.648 | -0.024 | 3 | 0.707 |
FGFR3 |
0.648 | 0.048 | 3 | 0.732 |
FLT4 |
0.647 | 0.043 | 3 | 0.696 |
AXL |
0.646 | -0.034 | 3 | 0.720 |
PDGFRA |
0.646 | -0.039 | 3 | 0.721 |
CK1G2 |
0.646 | 0.050 | -3 | 0.510 |
EPHA5 |
0.645 | 0.074 | 2 | 0.613 |
TEC |
0.645 | -0.041 | -1 | 0.649 |
ERBB2 |
0.645 | -0.008 | 1 | 0.633 |
TEK |
0.645 | -0.066 | 3 | 0.664 |
YANK2 |
0.644 | -0.013 | 2 | 0.383 |
PTK2 |
0.644 | 0.111 | -1 | 0.767 |
AAK1 |
0.643 | -0.039 | 1 | 0.415 |
MATK |
0.643 | 0.018 | -1 | 0.718 |
SYK |
0.643 | 0.084 | -1 | 0.789 |
DDR2 |
0.642 | 0.046 | 3 | 0.707 |
WEE1_TYR |
0.642 | -0.025 | -1 | 0.689 |
EPHA8 |
0.640 | 0.014 | -1 | 0.759 |
FYN |
0.640 | -0.028 | -1 | 0.688 |
BTK |
0.640 | -0.114 | -1 | 0.649 |
NEK10_TYR |
0.640 | -0.116 | 1 | 0.548 |
LYN |
0.640 | -0.050 | 3 | 0.649 |
EPHA1 |
0.640 | -0.031 | 3 | 0.697 |
IGF1R |
0.639 | 0.047 | 3 | 0.634 |
PTK2B |
0.639 | -0.023 | -1 | 0.658 |
EPHA2 |
0.638 | 0.063 | -1 | 0.795 |
CSK |
0.638 | -0.012 | 2 | 0.645 |
TNK1 |
0.637 | -0.113 | 3 | 0.707 |
FRK |
0.637 | -0.063 | -1 | 0.717 |
SRC |
0.632 | -0.063 | -1 | 0.692 |
ERBB4 |
0.631 | 0.025 | 1 | 0.572 |
MUSK |
0.628 | -0.055 | 1 | 0.523 |
FES |
0.625 | -0.002 | -1 | 0.682 |
ZAP70 |
0.624 | 0.042 | -1 | 0.725 |