Motif 583 (n=80)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1V8 | PPAN-P2RY11 | S364 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| A0JNW5 | BLTP3B | S987 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A0JNW5 | BLTP3B | S1007 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A6NMY6 | ANXA2P2 | S234 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O00299 | CLIC1 | S146 | ochoa | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}. |
| O14640 | DVL1 | S115 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O43639 | NCK2 | S90 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O60271 | SPAG9 | S363 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60506 | SYNCRIP | S159 | ochoa | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| P02545 | LMNA | S426 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P07355 | ANXA2 | S234 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08758 | ANXA5 | S116 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P09651 | HNRNPA1 | S95 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0DMV8 | HSPA1A | S40 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S40 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DPH7 | TUBA3C | S48 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S48 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11142 | HSPA8 | S40 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P13611 | VCAN | S1349 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P15036 | ETS2 | S220 | psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P17066 | HSPA6 | S42 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P22626 | HNRNPA2B1 | S102 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23284 | PPIB | S189 | ochoa | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
| P31645 | SLC6A4 | S611 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P34931 | HSPA1L | S42 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35555 | FBN1 | S2709 | ochoa | Fibrillin-1 [Cleaved into: Asprosin] | [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}. |
| P35610 | SOAT1 | S84 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P46777 | RPL5 | S185 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P48741 | HSPA7 | S42 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P51991 | HNRNPA3 | S116 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P52597 | HNRNPF | S21 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P54652 | HSPA2 | S41 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P55201 | BRPF1 | S844 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P68363 | TUBA1B | S48 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S48 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00403 | GTF2B | S70 | ochoa | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q00536 | CDK16 | S64 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q02410 | APBA1 | S246 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q09028 | RBBP4 | S110 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q09666 | AHNAK | S5577 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13151 | HNRNPA0 | S88 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q15334 | LLGL1 | S510 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q16576 | RBBP7 | S109 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16625 | OCLN | S45 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2WGJ9 | FER1L6 | S60 | ochoa | Fer-1-like protein 6 | None |
| Q32P51 | HNRNPA1L2 | S95 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q49A88 | CCDC14 | S124 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q5JSZ5 | PRRC2B | S194 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q6PEY2 | TUBA3E | S48 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q70J99 | UNC13D | S784 | ochoa | Protein unc-13 homolog D (Munc13-4) | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}. |
| Q71U36 | TUBA1A | S48 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z6I6 | ARHGAP30 | S820 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z739 | YTHDF3 | S383 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86SQ0 | PHLDB2 | S932 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q8NC51 | SERBP1 | S328 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCE2 | MTMR14 | S575 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q92888 | ARHGEF1 | S255 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q92945 | KHSRP | S129 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96J02 | ITCH | S221 | ochoa | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}. |
| Q96QT4 | TRPM7 | S1446 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T23 | RSF1 | S1391 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99460 | PSMD1 | S294 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99708 | RBBP8 | S345 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99759 | MAP3K3 | S520 | psp | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9BQE3 | TUBA1C | S48 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9C0C2 | TNKS1BP1 | S1073 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0K0 | BCL11B | S97 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0L4 | CSTF2T | S561 | ochoa | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9H773 | DCTPP1 | S24 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H8K7 | PAAT | S253 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9NP66 | HMG20A | S100 | ochoa | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}. |
| Q9NQ55 | PPAN | S364 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NTI5 | PDS5B | S1259 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9UHB7 | AFF4 | S526 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9Y2U5 | MAP3K2 | S514 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y4H2 | IRS2 | S518 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6C2 | EMILIN1 | S281 | ochoa | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity. {ECO:0000269|PubMed:36351433}. |
| A0A2R8Y4L2 | HNRNPA1L3 | S95 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| P78347 | GTF2I | S764 | EPSD | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P15121 | AKR1B1 | S264 | Sugiyama | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.110223e-16 | 15.955 |
| R-HSA-2262752 | Cellular responses to stress | 1.110223e-16 | 15.955 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.241540e-13 | 12.649 |
| R-HSA-9833482 | PKR-mediated signaling | 1.218359e-12 | 11.914 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.195518e-10 | 9.658 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.980515e-10 | 9.526 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.284616e-10 | 9.277 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.842366e-09 | 8.735 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.974520e-09 | 8.705 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.382081e-09 | 8.623 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.328684e-09 | 8.364 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.696153e-09 | 8.114 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.100406e-08 | 7.958 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.044866e-08 | 7.981 |
| R-HSA-190861 | Gap junction assembly | 1.544641e-08 | 7.811 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.050562e-08 | 7.516 |
| R-HSA-9646399 | Aggrephagy | 3.888179e-08 | 7.410 |
| R-HSA-190828 | Gap junction trafficking | 7.676932e-08 | 7.115 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.118320e-07 | 6.951 |
| R-HSA-437239 | Recycling pathway of L1 | 1.118320e-07 | 6.951 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.420344e-07 | 6.848 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.769382e-07 | 6.558 |
| R-HSA-9663891 | Selective autophagy | 3.573802e-07 | 6.447 |
| R-HSA-983189 | Kinesins | 4.599087e-07 | 6.337 |
| R-HSA-68882 | Mitotic Anaphase | 6.264048e-07 | 6.203 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.526024e-07 | 6.185 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.728328e-07 | 6.012 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.109933e-06 | 5.955 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.236943e-06 | 5.908 |
| R-HSA-1632852 | Macroautophagy | 1.375583e-06 | 5.862 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.457479e-06 | 5.836 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.809576e-06 | 5.742 |
| R-HSA-5620924 | Intraflagellar transport | 2.498684e-06 | 5.602 |
| R-HSA-9612973 | Autophagy | 2.999831e-06 | 5.523 |
| R-HSA-373760 | L1CAM interactions | 3.101348e-06 | 5.508 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.216165e-06 | 5.493 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.080529e-06 | 5.389 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.301191e-06 | 5.366 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.410316e-06 | 5.356 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.410316e-06 | 5.356 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.716266e-06 | 5.326 |
| R-HSA-391251 | Protein folding | 6.524154e-06 | 5.185 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.874396e-06 | 5.052 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.874396e-06 | 5.052 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.103787e-05 | 4.957 |
| R-HSA-69275 | G2/M Transition | 1.105401e-05 | 4.956 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.118406e-05 | 4.951 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.193076e-05 | 4.923 |
| R-HSA-9609690 | HCMV Early Events | 1.605762e-05 | 4.794 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.660254e-05 | 4.780 |
| R-HSA-913531 | Interferon Signaling | 1.859832e-05 | 4.731 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.944134e-05 | 4.711 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.446426e-05 | 4.611 |
| R-HSA-1640170 | Cell Cycle | 2.981818e-05 | 4.526 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.249409e-05 | 4.372 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.109226e-05 | 4.292 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.871422e-05 | 4.163 |
| R-HSA-68886 | M Phase | 8.935512e-05 | 4.049 |
| R-HSA-9609646 | HCMV Infection | 9.206030e-05 | 4.036 |
| R-HSA-68877 | Mitotic Prometaphase | 9.880754e-05 | 4.005 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.114163e-04 | 3.953 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.340726e-04 | 3.873 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.820952e-04 | 3.740 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.556011e-04 | 3.449 |
| R-HSA-422475 | Axon guidance | 4.328534e-04 | 3.364 |
| R-HSA-5617833 | Cilium Assembly | 5.519932e-04 | 3.258 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.964490e-04 | 3.224 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.251164e-04 | 3.140 |
| R-HSA-9675108 | Nervous system development | 7.536139e-04 | 3.123 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.644065e-04 | 3.117 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.376980e-03 | 2.861 |
| R-HSA-112316 | Neuronal System | 1.723148e-03 | 2.764 |
| R-HSA-9824446 | Viral Infection Pathways | 1.669813e-03 | 2.777 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.165430e-03 | 2.664 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.399165e-03 | 2.620 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.953358e-03 | 2.530 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.154100e-03 | 2.501 |
| R-HSA-449147 | Signaling by Interleukins | 4.172212e-03 | 2.380 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.627965e-03 | 2.250 |
| R-HSA-774815 | Nucleosome assembly | 5.627965e-03 | 2.250 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.187401e-03 | 2.087 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.066203e-02 | 1.972 |
| R-HSA-2559583 | Cellular Senescence | 1.125646e-02 | 1.949 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.470400e-02 | 1.833 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.444061e-02 | 1.840 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.546304e-02 | 1.811 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.574791e-02 | 1.803 |
| R-HSA-72172 | mRNA Splicing | 1.786473e-02 | 1.748 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 1.992125e-02 | 1.701 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.101967e-02 | 1.677 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.442377e-02 | 1.612 |
| R-HSA-1500620 | Meiosis | 2.510917e-02 | 1.600 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.546806e-02 | 1.594 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.597256e-02 | 1.585 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 2.647389e-02 | 1.577 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.727780e-02 | 1.564 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.298312e-02 | 1.482 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.418598e-02 | 1.466 |
| R-HSA-8953854 | Metabolism of RNA | 2.891604e-02 | 1.539 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.795394e-02 | 1.554 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.237301e-02 | 1.490 |
| R-HSA-168256 | Immune System | 2.817070e-02 | 1.550 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.002473e-02 | 1.523 |
| R-HSA-4641258 | Degradation of DVL | 3.564128e-02 | 1.448 |
| R-HSA-5663205 | Infectious disease | 3.615295e-02 | 1.442 |
| R-HSA-1566948 | Elastic fibre formation | 3.712025e-02 | 1.430 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.014766e-02 | 1.396 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.014766e-02 | 1.396 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.014766e-02 | 1.396 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.169537e-02 | 1.380 |
| R-HSA-6798695 | Neutrophil degranulation | 4.241830e-02 | 1.372 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.326526e-02 | 1.364 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.485698e-02 | 1.348 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.556278e-02 | 1.341 |
| R-HSA-74713 | IRS activation | 4.587251e-02 | 1.338 |
| R-HSA-9710421 | Defective pyroptosis | 4.647017e-02 | 1.333 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 5.859167e-02 | 1.232 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 5.859167e-02 | 1.232 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 5.859167e-02 | 1.232 |
| R-HSA-112412 | SOS-mediated signalling | 6.488810e-02 | 1.188 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.488810e-02 | 1.188 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 6.488810e-02 | 1.188 |
| R-HSA-1221632 | Meiotic synapsis | 6.370716e-02 | 1.196 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 5.225323e-02 | 1.282 |
| R-HSA-447041 | CHL1 interactions | 6.488810e-02 | 1.188 |
| R-HSA-73886 | Chromosome Maintenance | 6.298659e-02 | 1.201 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.189806e-02 | 1.208 |
| R-HSA-1266738 | Developmental Biology | 6.488615e-02 | 1.188 |
| R-HSA-75153 | Apoptotic execution phase | 5.143505e-02 | 1.289 |
| R-HSA-5357801 | Programmed Cell Death | 6.544974e-02 | 1.184 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.737843e-02 | 1.171 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.111837e-02 | 1.148 |
| R-HSA-5652227 | Fructose biosynthesis | 7.114282e-02 | 1.148 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 7.114282e-02 | 1.148 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.114282e-02 | 1.148 |
| R-HSA-1474165 | Reproduction | 7.567468e-02 | 1.121 |
| R-HSA-9613354 | Lipophagy | 7.735608e-02 | 1.112 |
| R-HSA-201688 | WNT mediated activation of DVL | 7.735608e-02 | 1.112 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 8.352816e-02 | 1.078 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 8.352816e-02 | 1.078 |
| R-HSA-2022923 | DS-GAG biosynthesis | 9.574986e-02 | 1.019 |
| R-HSA-428540 | Activation of RAC1 | 9.574986e-02 | 1.019 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.018000e-01 | 0.992 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.078101e-01 | 0.967 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.685171e-02 | 1.114 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.272606e-02 | 1.082 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.272606e-02 | 1.082 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 8.873364e-02 | 1.052 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.032277e-01 | 0.986 |
| R-HSA-380287 | Centrosome maturation | 1.074818e-01 | 0.969 |
| R-HSA-198203 | PI3K/AKT activation | 8.352816e-02 | 1.078 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.053488e-01 | 0.977 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 9.574986e-02 | 1.019 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.018000e-01 | 0.992 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 9.486693e-02 | 1.023 |
| R-HSA-74749 | Signal attenuation | 8.352816e-02 | 1.078 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 9.574986e-02 | 1.019 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 9.902203e-02 | 1.004 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.685171e-02 | 1.114 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 8.873364e-02 | 1.052 |
| R-HSA-69242 | S Phase | 1.013436e-01 | 0.994 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.137803e-01 | 0.944 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 9.693804e-02 | 1.014 |
| R-HSA-5632684 | Hedgehog 'on' state | 9.902203e-02 | 1.004 |
| R-HSA-2586552 | Signaling by Leptin | 8.352816e-02 | 1.078 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.011187e-01 | 0.995 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 9.693804e-02 | 1.014 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.096264e-01 | 0.960 |
| R-HSA-4839726 | Chromatin organization | 1.077417e-01 | 0.968 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.685171e-02 | 1.114 |
| R-HSA-6807070 | PTEN Regulation | 8.810878e-02 | 1.055 |
| R-HSA-199991 | Membrane Trafficking | 8.114150e-02 | 1.091 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.693804e-02 | 1.014 |
| R-HSA-1280218 | Adaptive Immune System | 1.025590e-01 | 0.989 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 8.965933e-02 | 1.047 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.810878e-02 | 1.055 |
| R-HSA-109582 | Hemostasis | 9.185143e-02 | 1.037 |
| R-HSA-4086400 | PCP/CE pathway | 1.139495e-01 | 0.943 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.139495e-01 | 0.943 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.197109e-01 | 0.922 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.256022e-01 | 0.901 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 1.314544e-01 | 0.881 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 1.314544e-01 | 0.881 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 1.372679e-01 | 0.862 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.487793e-01 | 0.827 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.544778e-01 | 0.811 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.544778e-01 | 0.811 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.544778e-01 | 0.811 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.544778e-01 | 0.811 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.544778e-01 | 0.811 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.544778e-01 | 0.811 |
| R-HSA-2022870 | CS-GAG biosynthesis | 1.657618e-01 | 0.781 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.878839e-01 | 0.726 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.094247e-01 | 0.679 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.094247e-01 | 0.679 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.094247e-01 | 0.679 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.663409e-01 | 0.779 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.430280e-01 | 0.845 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.592751e-01 | 0.798 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.314544e-01 | 0.881 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.256022e-01 | 0.901 |
| R-HSA-9664420 | Killing mechanisms | 1.256022e-01 | 0.901 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.303993e-01 | 0.638 |
| R-HSA-3928664 | Ephrin signaling | 1.430427e-01 | 0.845 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.355562e-01 | 0.628 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.303993e-01 | 0.638 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.987260e-01 | 0.702 |
| R-HSA-1538133 | G0 and Early G1 | 2.252079e-01 | 0.647 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.199818e-01 | 0.658 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.430427e-01 | 0.845 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.430427e-01 | 0.845 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.713476e-01 | 0.766 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.824085e-01 | 0.739 |
| R-HSA-525793 | Myogenesis | 1.933230e-01 | 0.714 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.252079e-01 | 0.647 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.271724e-01 | 0.896 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.830301e-01 | 0.737 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.830301e-01 | 0.737 |
| R-HSA-429947 | Deadenylation of mRNA | 1.824085e-01 | 0.739 |
| R-HSA-2024101 | CS/DS degradation | 2.355562e-01 | 0.628 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.197109e-01 | 0.922 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.147208e-01 | 0.668 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.355562e-01 | 0.628 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.933230e-01 | 0.714 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.758454e-01 | 0.755 |
| R-HSA-70370 | Galactose catabolism | 1.314544e-01 | 0.881 |
| R-HSA-373753 | Nephrin family interactions | 1.544778e-01 | 0.811 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.878839e-01 | 0.726 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.878839e-01 | 0.726 |
| R-HSA-5652084 | Fructose metabolism | 1.713476e-01 | 0.766 |
| R-HSA-3295583 | TRP channels | 1.933230e-01 | 0.714 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.040931e-01 | 0.690 |
| R-HSA-3214847 | HATs acetylate histones | 1.687085e-01 | 0.773 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.874803e-01 | 0.727 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.256022e-01 | 0.901 |
| R-HSA-196108 | Pregnenolone biosynthesis | 1.544778e-01 | 0.811 |
| R-HSA-112311 | Neurotransmitter clearance | 2.147208e-01 | 0.668 |
| R-HSA-8876725 | Protein methylation | 1.197109e-01 | 0.922 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.430280e-01 | 0.845 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.375513e-01 | 0.862 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.824504e-01 | 0.739 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.303993e-01 | 0.638 |
| R-HSA-68875 | Mitotic Prophase | 2.268898e-01 | 0.644 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.183161e-01 | 0.927 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.199818e-01 | 0.658 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.713476e-01 | 0.766 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.097084e-01 | 0.678 |
| R-HSA-1474244 | Extracellular matrix organization | 2.102511e-01 | 0.677 |
| R-HSA-186763 | Downstream signal transduction | 2.199818e-01 | 0.658 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.730803e-01 | 0.762 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.620739e-01 | 0.790 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.931212e-01 | 0.714 |
| R-HSA-8964038 | LDL clearance | 1.713476e-01 | 0.766 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.758454e-01 | 0.755 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.824085e-01 | 0.739 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.824085e-01 | 0.739 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.390830e-01 | 0.857 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.390830e-01 | 0.857 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.257351e-01 | 0.646 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.987260e-01 | 0.702 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.878839e-01 | 0.726 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.768965e-01 | 0.752 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.734609e-01 | 0.761 |
| R-HSA-1500931 | Cell-Cell communication | 1.896725e-01 | 0.722 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.758031e-01 | 0.755 |
| R-HSA-418990 | Adherens junctions interactions | 2.148813e-01 | 0.668 |
| R-HSA-190236 | Signaling by FGFR | 1.663409e-01 | 0.779 |
| R-HSA-1643685 | Disease | 1.964294e-01 | 0.707 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.279826e-01 | 0.642 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.339151e-01 | 0.873 |
| R-HSA-109581 | Apoptosis | 1.211076e-01 | 0.917 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.476332e-01 | 0.831 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.421638e-01 | 0.847 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 2.406789e-01 | 0.619 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.406789e-01 | 0.619 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.406789e-01 | 0.619 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.406789e-01 | 0.619 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.406789e-01 | 0.619 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.406789e-01 | 0.619 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.406789e-01 | 0.619 |
| R-HSA-69206 | G1/S Transition | 2.416979e-01 | 0.617 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.430783e-01 | 0.614 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.457675e-01 | 0.609 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.457675e-01 | 0.609 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.457675e-01 | 0.609 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.457675e-01 | 0.609 |
| R-HSA-169911 | Regulation of Apoptosis | 2.457675e-01 | 0.609 |
| R-HSA-381042 | PERK regulates gene expression | 2.457675e-01 | 0.609 |
| R-HSA-114608 | Platelet degranulation | 2.466453e-01 | 0.608 |
| R-HSA-69481 | G2/M Checkpoints | 2.466453e-01 | 0.608 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.508224e-01 | 0.601 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.508224e-01 | 0.601 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.508224e-01 | 0.601 |
| R-HSA-8853659 | RET signaling | 2.508224e-01 | 0.601 |
| R-HSA-4641257 | Degradation of AXIN | 2.558437e-01 | 0.592 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.558437e-01 | 0.592 |
| R-HSA-9843745 | Adipogenesis | 2.590289e-01 | 0.587 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.608317e-01 | 0.584 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.608317e-01 | 0.584 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.639860e-01 | 0.578 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.657865e-01 | 0.575 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.657865e-01 | 0.575 |
| R-HSA-69541 | Stabilization of p53 | 2.657865e-01 | 0.575 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.657865e-01 | 0.575 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.657865e-01 | 0.575 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.707084e-01 | 0.567 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.707084e-01 | 0.567 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.707084e-01 | 0.567 |
| R-HSA-421270 | Cell-cell junction organization | 2.736586e-01 | 0.563 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.739012e-01 | 0.562 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.755977e-01 | 0.560 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.755977e-01 | 0.560 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.755977e-01 | 0.560 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.755977e-01 | 0.560 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.788577e-01 | 0.555 |
| R-HSA-167161 | HIV Transcription Initiation | 2.804544e-01 | 0.552 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.804544e-01 | 0.552 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.804544e-01 | 0.552 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.804544e-01 | 0.552 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.804544e-01 | 0.552 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.804544e-01 | 0.552 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 2.804544e-01 | 0.552 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.827384e-01 | 0.549 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.900714e-01 | 0.537 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.900714e-01 | 0.537 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.900714e-01 | 0.537 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.948320e-01 | 0.530 |
| R-HSA-9907900 | Proteasome assembly | 2.948320e-01 | 0.530 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.948320e-01 | 0.530 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.995610e-01 | 0.524 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 2.995610e-01 | 0.524 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.995610e-01 | 0.524 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.995610e-01 | 0.524 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.995610e-01 | 0.524 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.995610e-01 | 0.524 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.995610e-01 | 0.524 |
| R-HSA-9824272 | Somitogenesis | 2.995610e-01 | 0.524 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.011260e-01 | 0.521 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.042585e-01 | 0.517 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.042585e-01 | 0.517 |
| R-HSA-9675135 | Diseases of DNA repair | 3.042585e-01 | 0.517 |
| R-HSA-9758941 | Gastrulation | 3.085276e-01 | 0.511 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.089249e-01 | 0.510 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.109917e-01 | 0.507 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.159146e-01 | 0.500 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.159146e-01 | 0.500 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.159146e-01 | 0.500 |
| R-HSA-9766229 | Degradation of CDH1 | 3.181647e-01 | 0.497 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.181647e-01 | 0.497 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.181647e-01 | 0.497 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.227387e-01 | 0.491 |
| R-HSA-109704 | PI3K Cascade | 3.227387e-01 | 0.491 |
| R-HSA-446728 | Cell junction organization | 3.229424e-01 | 0.491 |
| R-HSA-912446 | Meiotic recombination | 3.272822e-01 | 0.485 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.272822e-01 | 0.485 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.272822e-01 | 0.485 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.272822e-01 | 0.485 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.317955e-01 | 0.479 |
| R-HSA-72187 | mRNA 3'-end processing | 3.317955e-01 | 0.479 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.317955e-01 | 0.479 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.317955e-01 | 0.479 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.317955e-01 | 0.479 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.317955e-01 | 0.479 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.362788e-01 | 0.473 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.362788e-01 | 0.473 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.362788e-01 | 0.473 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.362788e-01 | 0.473 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.362788e-01 | 0.473 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.362788e-01 | 0.473 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.407324e-01 | 0.468 |
| R-HSA-9679506 | SARS-CoV Infections | 3.439320e-01 | 0.464 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 3.451563e-01 | 0.462 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.451563e-01 | 0.462 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.495508e-01 | 0.456 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.495508e-01 | 0.456 |
| R-HSA-112399 | IRS-mediated signalling | 3.539161e-01 | 0.451 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.539161e-01 | 0.451 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.539161e-01 | 0.451 |
| R-HSA-74160 | Gene expression (Transcription) | 3.558623e-01 | 0.449 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.625597e-01 | 0.441 |
| R-HSA-212436 | Generic Transcription Pathway | 3.642456e-01 | 0.439 |
| R-HSA-351202 | Metabolism of polyamines | 3.668385e-01 | 0.436 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.710888e-01 | 0.431 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.710888e-01 | 0.431 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.710888e-01 | 0.431 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.710888e-01 | 0.431 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.753109e-01 | 0.426 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.753109e-01 | 0.426 |
| R-HSA-186797 | Signaling by PDGF | 3.753109e-01 | 0.426 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.795048e-01 | 0.421 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.836709e-01 | 0.416 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.836709e-01 | 0.416 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.836709e-01 | 0.416 |
| R-HSA-168255 | Influenza Infection | 3.837596e-01 | 0.416 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.878092e-01 | 0.411 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.878092e-01 | 0.411 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.878092e-01 | 0.411 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.932381e-01 | 0.405 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.960035e-01 | 0.402 |
| R-HSA-196071 | Metabolism of steroid hormones | 3.960035e-01 | 0.402 |
| R-HSA-167172 | Transcription of the HIV genome | 4.000598e-01 | 0.398 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 4.000598e-01 | 0.398 |
| R-HSA-5218859 | Regulated Necrosis | 4.000598e-01 | 0.398 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.080916e-01 | 0.389 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.080916e-01 | 0.389 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.120675e-01 | 0.385 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.120675e-01 | 0.385 |
| R-HSA-3000178 | ECM proteoglycans | 4.120675e-01 | 0.385 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.143227e-01 | 0.383 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.160169e-01 | 0.381 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 4.160169e-01 | 0.381 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.199400e-01 | 0.377 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.199400e-01 | 0.377 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.212609e-01 | 0.375 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.238370e-01 | 0.373 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.238370e-01 | 0.373 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.238370e-01 | 0.373 |
| R-HSA-5689603 | UCH proteinases | 4.315533e-01 | 0.365 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.315533e-01 | 0.365 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.391673e-01 | 0.357 |
| R-HSA-5619084 | ABC transporter disorders | 4.391673e-01 | 0.357 |
| R-HSA-216083 | Integrin cell surface interactions | 4.391673e-01 | 0.357 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.503992e-01 | 0.346 |
| R-HSA-597592 | Post-translational protein modification | 4.543131e-01 | 0.343 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.577630e-01 | 0.339 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.650290e-01 | 0.333 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.650290e-01 | 0.333 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.650290e-01 | 0.333 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.686258e-01 | 0.329 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.721986e-01 | 0.326 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.721986e-01 | 0.326 |
| R-HSA-156902 | Peptide chain elongation | 4.792730e-01 | 0.319 |
| R-HSA-8951664 | Neddylation | 4.818245e-01 | 0.317 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.827748e-01 | 0.316 |
| R-HSA-202424 | Downstream TCR signaling | 4.862534e-01 | 0.313 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.897087e-01 | 0.310 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.931411e-01 | 0.307 |
| R-HSA-162906 | HIV Infection | 4.947558e-01 | 0.306 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.965505e-01 | 0.304 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.965505e-01 | 0.304 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.965505e-01 | 0.304 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.965505e-01 | 0.304 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.999373e-01 | 0.301 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.033014e-01 | 0.298 |
| R-HSA-1474290 | Collagen formation | 5.033014e-01 | 0.298 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.066432e-01 | 0.295 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.066432e-01 | 0.295 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.099626e-01 | 0.292 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.099626e-01 | 0.292 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.132600e-01 | 0.290 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.165353e-01 | 0.287 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.165353e-01 | 0.287 |
| R-HSA-157118 | Signaling by NOTCH | 5.220719e-01 | 0.282 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.230206e-01 | 0.281 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.262309e-01 | 0.279 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.294198e-01 | 0.276 |
| R-HSA-1483255 | PI Metabolism | 5.325874e-01 | 0.274 |
| R-HSA-192823 | Viral mRNA Translation | 5.357338e-01 | 0.271 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.388593e-01 | 0.269 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.388593e-01 | 0.269 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.511541e-01 | 0.259 |
| R-HSA-69239 | Synthesis of DNA | 5.511541e-01 | 0.259 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.541768e-01 | 0.256 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.541768e-01 | 0.256 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.541768e-01 | 0.256 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.541768e-01 | 0.256 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.571792e-01 | 0.254 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.582525e-01 | 0.253 |
| R-HSA-202403 | TCR signaling | 5.601616e-01 | 0.252 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.660669e-01 | 0.247 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.660669e-01 | 0.247 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.679561e-01 | 0.246 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.718936e-01 | 0.243 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.718936e-01 | 0.243 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.804886e-01 | 0.236 |
| R-HSA-162582 | Signal Transduction | 5.826064e-01 | 0.235 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.833154e-01 | 0.234 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.833154e-01 | 0.234 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.887669e-01 | 0.230 |
| R-HSA-5693538 | Homology Directed Repair | 5.889126e-01 | 0.230 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.889126e-01 | 0.230 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.916831e-01 | 0.228 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.971689e-01 | 0.224 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.025817e-01 | 0.220 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.025817e-01 | 0.220 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.034358e-01 | 0.219 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.052610e-01 | 0.218 |
| R-HSA-194138 | Signaling by VEGF | 6.105660e-01 | 0.214 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.159484e-01 | 0.210 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.183914e-01 | 0.209 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.235215e-01 | 0.205 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.281604e-01 | 0.202 |
| R-HSA-9909396 | Circadian clock | 6.310889e-01 | 0.200 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.310889e-01 | 0.200 |
| R-HSA-195721 | Signaling by WNT | 6.315945e-01 | 0.200 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.457745e-01 | 0.190 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.598806e-01 | 0.181 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.621769e-01 | 0.179 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.644579e-01 | 0.178 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.724723e-01 | 0.172 |
| R-HSA-166520 | Signaling by NTRKs | 6.734301e-01 | 0.172 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.800028e-01 | 0.167 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.843117e-01 | 0.165 |
| R-HSA-69306 | DNA Replication | 6.843117e-01 | 0.165 |
| R-HSA-73887 | Death Receptor Signaling | 6.864445e-01 | 0.163 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.885630e-01 | 0.162 |
| R-HSA-162587 | HIV Life Cycle | 6.927577e-01 | 0.159 |
| R-HSA-168249 | Innate Immune System | 6.928652e-01 | 0.159 |
| R-HSA-9711097 | Cellular response to starvation | 6.948340e-01 | 0.158 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.948340e-01 | 0.158 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.989449e-01 | 0.156 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.011286e-01 | 0.154 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.070029e-01 | 0.151 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.082226e-01 | 0.150 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.205935e-01 | 0.142 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.224833e-01 | 0.141 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.262250e-01 | 0.139 |
| R-HSA-3781865 | Diseases of glycosylation | 7.459286e-01 | 0.127 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.527396e-01 | 0.123 |
| R-HSA-983712 | Ion channel transport | 7.544139e-01 | 0.122 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.569750e-01 | 0.121 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 7.609994e-01 | 0.119 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.767077e-01 | 0.110 |
| R-HSA-397014 | Muscle contraction | 7.913925e-01 | 0.102 |
| R-HSA-72766 | Translation | 8.077345e-01 | 0.093 |
| R-HSA-72312 | rRNA processing | 8.179518e-01 | 0.087 |
| R-HSA-15869 | Metabolism of nucleotides | 8.228470e-01 | 0.085 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.320970e-01 | 0.080 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.356463e-01 | 0.078 |
| R-HSA-5688426 | Deubiquitination | 8.443752e-01 | 0.073 |
| R-HSA-392499 | Metabolism of proteins | 8.470292e-01 | 0.072 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.575903e-01 | 0.067 |
| R-HSA-9658195 | Leishmania infection | 8.696928e-01 | 0.061 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.696928e-01 | 0.061 |
| R-HSA-1483257 | Phospholipid metabolism | 8.815882e-01 | 0.055 |
| R-HSA-8957322 | Metabolism of steroids | 9.029130e-01 | 0.044 |
| R-HSA-382551 | Transport of small molecules | 9.095692e-01 | 0.041 |
| R-HSA-73894 | DNA Repair | 9.241613e-01 | 0.034 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.310972e-01 | 0.031 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.416024e-01 | 0.026 |
| R-HSA-5668914 | Diseases of metabolism | 9.525104e-01 | 0.021 |
| R-HSA-388396 | GPCR downstream signalling | 9.957805e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.976544e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.997048e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.778 | 0.231 | 1 | 0.757 |
COT |
0.774 | 0.136 | 2 | 0.745 |
KIS |
0.771 | 0.220 | 1 | 0.638 |
HIPK4 |
0.764 | 0.239 | 1 | 0.741 |
NDR2 |
0.764 | 0.104 | -3 | 0.782 |
GCN2 |
0.763 | 0.118 | 2 | 0.651 |
CLK2 |
0.762 | 0.221 | -3 | 0.728 |
PRKD1 |
0.761 | 0.180 | -3 | 0.773 |
MOS |
0.760 | 0.144 | 1 | 0.803 |
PIM3 |
0.758 | 0.089 | -3 | 0.794 |
SRPK1 |
0.758 | 0.126 | -3 | 0.749 |
IKKB |
0.758 | 0.028 | -2 | 0.713 |
MTOR |
0.758 | 0.020 | 1 | 0.776 |
DSTYK |
0.757 | 0.102 | 2 | 0.752 |
DYRK2 |
0.756 | 0.176 | 1 | 0.669 |
PRKD2 |
0.756 | 0.168 | -3 | 0.724 |
RSK2 |
0.755 | 0.096 | -3 | 0.753 |
CDC7 |
0.755 | -0.020 | 1 | 0.740 |
GRK1 |
0.754 | 0.082 | -2 | 0.795 |
NEK6 |
0.753 | 0.077 | -2 | 0.859 |
CAMK2G |
0.753 | 0.027 | 2 | 0.675 |
RAF1 |
0.753 | 0.058 | 1 | 0.775 |
TBK1 |
0.752 | 0.029 | 1 | 0.716 |
IKKA |
0.752 | 0.055 | -2 | 0.709 |
PRPK |
0.751 | -0.020 | -1 | 0.682 |
CDKL1 |
0.751 | 0.088 | -3 | 0.790 |
CDKL5 |
0.751 | 0.106 | -3 | 0.786 |
IKKE |
0.750 | 0.022 | 1 | 0.701 |
SKMLCK |
0.750 | 0.098 | -2 | 0.806 |
DYRK4 |
0.749 | 0.184 | 1 | 0.581 |
P90RSK |
0.749 | 0.076 | -3 | 0.758 |
RSK3 |
0.749 | 0.070 | -3 | 0.747 |
LATS2 |
0.749 | 0.050 | -5 | 0.657 |
TGFBR1 |
0.749 | 0.191 | -2 | 0.851 |
GRK7 |
0.749 | 0.135 | 1 | 0.781 |
CAMK2B |
0.749 | 0.094 | 2 | 0.662 |
CAMK1B |
0.749 | 0.053 | -3 | 0.811 |
ATR |
0.748 | 0.031 | 1 | 0.790 |
PKN3 |
0.748 | 0.070 | -3 | 0.786 |
TGFBR2 |
0.748 | 0.079 | -2 | 0.880 |
SRPK2 |
0.748 | 0.102 | -3 | 0.682 |
LATS1 |
0.748 | 0.165 | -3 | 0.796 |
CAMK2A |
0.747 | 0.095 | 2 | 0.703 |
FAM20C |
0.747 | 0.034 | 2 | 0.476 |
BMPR2 |
0.747 | 0.071 | -2 | 0.867 |
PDHK4 |
0.746 | -0.103 | 1 | 0.810 |
AURC |
0.746 | 0.098 | -2 | 0.643 |
ATM |
0.746 | 0.065 | 1 | 0.732 |
MAPKAPK2 |
0.745 | 0.109 | -3 | 0.696 |
PIM1 |
0.745 | 0.077 | -3 | 0.749 |
CLK4 |
0.744 | 0.144 | -3 | 0.737 |
GRK5 |
0.744 | -0.028 | -3 | 0.789 |
CAMK2D |
0.744 | 0.044 | -3 | 0.786 |
NDR1 |
0.744 | 0.018 | -3 | 0.782 |
ERK5 |
0.744 | 0.034 | 1 | 0.779 |
BMPR1B |
0.744 | 0.154 | 1 | 0.671 |
HUNK |
0.744 | -0.006 | 2 | 0.711 |
MSK1 |
0.744 | 0.111 | -3 | 0.732 |
SRPK3 |
0.744 | 0.086 | -3 | 0.727 |
CHAK2 |
0.743 | 0.028 | -1 | 0.705 |
NEK7 |
0.742 | -0.034 | -3 | 0.762 |
MSK2 |
0.742 | 0.076 | -3 | 0.725 |
ULK2 |
0.742 | -0.080 | 2 | 0.605 |
ICK |
0.742 | 0.081 | -3 | 0.802 |
GRK4 |
0.742 | 0.016 | -2 | 0.822 |
PKACG |
0.741 | 0.050 | -2 | 0.719 |
PDHK1 |
0.741 | -0.058 | 1 | 0.798 |
GRK6 |
0.741 | 0.010 | 1 | 0.794 |
RIPK3 |
0.741 | -0.043 | 3 | 0.448 |
CAMLCK |
0.740 | 0.042 | -2 | 0.809 |
HIPK2 |
0.740 | 0.148 | 1 | 0.571 |
RSK4 |
0.740 | 0.081 | -3 | 0.723 |
P70S6KB |
0.740 | 0.054 | -3 | 0.763 |
ALK4 |
0.740 | 0.128 | -2 | 0.871 |
NUAK2 |
0.740 | 0.007 | -3 | 0.783 |
DNAPK |
0.739 | 0.070 | 1 | 0.692 |
PKN2 |
0.739 | 0.017 | -3 | 0.786 |
ALK2 |
0.739 | 0.169 | -2 | 0.856 |
DAPK2 |
0.739 | 0.045 | -3 | 0.817 |
PLK3 |
0.739 | 0.083 | 2 | 0.663 |
MASTL |
0.738 | -0.074 | -2 | 0.787 |
PKACB |
0.738 | 0.106 | -2 | 0.655 |
CLK1 |
0.738 | 0.119 | -3 | 0.709 |
WNK1 |
0.738 | -0.048 | -2 | 0.802 |
NIK |
0.737 | -0.027 | -3 | 0.815 |
PRKX |
0.737 | 0.106 | -3 | 0.652 |
MAPKAPK3 |
0.737 | 0.060 | -3 | 0.729 |
MLK1 |
0.737 | -0.070 | 2 | 0.657 |
MST4 |
0.737 | -0.036 | 2 | 0.698 |
PLK1 |
0.737 | 0.070 | -2 | 0.843 |
NLK |
0.737 | -0.055 | 1 | 0.771 |
CDK1 |
0.735 | 0.044 | 1 | 0.570 |
PRP4 |
0.735 | 0.204 | -3 | 0.814 |
PKCD |
0.735 | 0.003 | 2 | 0.632 |
ULK1 |
0.734 | -0.078 | -3 | 0.735 |
BCKDK |
0.734 | -0.089 | -1 | 0.639 |
PAK1 |
0.734 | 0.029 | -2 | 0.744 |
MNK2 |
0.733 | 0.032 | -2 | 0.743 |
ACVR2B |
0.733 | 0.114 | -2 | 0.862 |
AURA |
0.733 | 0.077 | -2 | 0.623 |
YSK4 |
0.733 | 0.063 | 1 | 0.721 |
AMPKA1 |
0.733 | -0.039 | -3 | 0.791 |
CDK18 |
0.733 | 0.059 | 1 | 0.553 |
ANKRD3 |
0.733 | -0.003 | 1 | 0.826 |
HIPK1 |
0.732 | 0.120 | 1 | 0.678 |
MARK4 |
0.732 | -0.082 | 4 | 0.620 |
DYRK1A |
0.732 | 0.113 | 1 | 0.684 |
P38B |
0.732 | 0.086 | 1 | 0.603 |
ACVR2A |
0.732 | 0.098 | -2 | 0.863 |
DLK |
0.732 | -0.026 | 1 | 0.783 |
TLK2 |
0.731 | 0.071 | 1 | 0.765 |
CAMK4 |
0.731 | 0.008 | -3 | 0.754 |
DYRK3 |
0.731 | 0.128 | 1 | 0.689 |
MNK1 |
0.730 | 0.026 | -2 | 0.752 |
CDK8 |
0.730 | 0.021 | 1 | 0.609 |
NEK9 |
0.730 | -0.068 | 2 | 0.659 |
CDK19 |
0.730 | 0.046 | 1 | 0.569 |
DYRK1B |
0.730 | 0.107 | 1 | 0.610 |
PASK |
0.730 | 0.137 | -3 | 0.803 |
SGK3 |
0.729 | 0.065 | -3 | 0.735 |
MLK3 |
0.729 | -0.029 | 2 | 0.591 |
PRKD3 |
0.729 | 0.066 | -3 | 0.704 |
MLK2 |
0.729 | -0.043 | 2 | 0.640 |
AMPKA2 |
0.729 | -0.025 | -3 | 0.768 |
PKCZ |
0.729 | 0.003 | 2 | 0.611 |
AURB |
0.728 | 0.047 | -2 | 0.643 |
AKT2 |
0.728 | 0.077 | -3 | 0.675 |
PKCB |
0.728 | -0.008 | 2 | 0.593 |
P38D |
0.728 | 0.102 | 1 | 0.514 |
P38A |
0.728 | 0.062 | 1 | 0.662 |
PKCG |
0.727 | -0.023 | 2 | 0.594 |
PKCA |
0.727 | 0.004 | 2 | 0.583 |
TSSK2 |
0.727 | -0.040 | -5 | 0.769 |
CK2A2 |
0.727 | 0.075 | 1 | 0.612 |
CDK3 |
0.727 | 0.035 | 1 | 0.521 |
TSSK1 |
0.726 | -0.036 | -3 | 0.811 |
CDK7 |
0.726 | -0.003 | 1 | 0.609 |
PAK3 |
0.726 | -0.020 | -2 | 0.735 |
BMPR1A |
0.725 | 0.112 | 1 | 0.651 |
DRAK1 |
0.725 | 0.026 | 1 | 0.722 |
TTBK2 |
0.725 | -0.129 | 2 | 0.523 |
PKR |
0.725 | -0.002 | 1 | 0.797 |
RIPK1 |
0.725 | -0.114 | 1 | 0.792 |
GSK3A |
0.725 | 0.037 | 4 | 0.391 |
PHKG1 |
0.724 | -0.001 | -3 | 0.767 |
NIM1 |
0.724 | -0.093 | 3 | 0.464 |
CHK1 |
0.724 | 0.025 | -3 | 0.758 |
MYLK4 |
0.724 | 0.030 | -2 | 0.727 |
JNK2 |
0.723 | 0.038 | 1 | 0.553 |
WNK3 |
0.723 | -0.217 | 1 | 0.789 |
PKACA |
0.723 | 0.085 | -2 | 0.606 |
DCAMKL1 |
0.723 | 0.042 | -3 | 0.727 |
PERK |
0.723 | 0.040 | -2 | 0.866 |
IRE1 |
0.723 | -0.103 | 1 | 0.764 |
CDK13 |
0.723 | -0.003 | 1 | 0.590 |
SMG1 |
0.722 | -0.040 | 1 | 0.749 |
CDK17 |
0.722 | 0.026 | 1 | 0.505 |
MEK1 |
0.722 | -0.072 | 2 | 0.684 |
PKG2 |
0.722 | 0.032 | -2 | 0.652 |
PAK2 |
0.722 | -0.013 | -2 | 0.742 |
NUAK1 |
0.722 | -0.040 | -3 | 0.738 |
PAK6 |
0.722 | 0.007 | -2 | 0.676 |
CDK5 |
0.722 | -0.006 | 1 | 0.633 |
PLK2 |
0.721 | 0.074 | -3 | 0.700 |
ERK1 |
0.721 | 0.029 | 1 | 0.583 |
CDK2 |
0.721 | -0.016 | 1 | 0.682 |
JNK3 |
0.721 | 0.013 | 1 | 0.609 |
PLK4 |
0.721 | -0.048 | 2 | 0.486 |
P38G |
0.720 | 0.036 | 1 | 0.491 |
TLK1 |
0.720 | 0.079 | -2 | 0.845 |
QSK |
0.720 | -0.056 | 4 | 0.587 |
HIPK3 |
0.720 | 0.086 | 1 | 0.680 |
GSK3B |
0.719 | 0.002 | 4 | 0.375 |
PKCH |
0.719 | -0.048 | 2 | 0.572 |
NEK2 |
0.719 | -0.064 | 2 | 0.633 |
HRI |
0.718 | -0.025 | -2 | 0.872 |
PIM2 |
0.718 | 0.042 | -3 | 0.722 |
MLK4 |
0.718 | -0.076 | 2 | 0.564 |
CAMK1G |
0.718 | 0.014 | -3 | 0.728 |
VRK2 |
0.718 | -0.139 | 1 | 0.835 |
CK2A1 |
0.718 | 0.060 | 1 | 0.585 |
CDK12 |
0.718 | -0.001 | 1 | 0.565 |
IRE2 |
0.717 | -0.114 | 2 | 0.577 |
MELK |
0.716 | -0.054 | -3 | 0.755 |
CDK14 |
0.716 | 0.020 | 1 | 0.595 |
MAPKAPK5 |
0.715 | -0.010 | -3 | 0.709 |
BRSK1 |
0.715 | -0.057 | -3 | 0.741 |
SIK |
0.715 | -0.057 | -3 | 0.710 |
CDK9 |
0.715 | -0.013 | 1 | 0.599 |
GRK2 |
0.715 | -0.046 | -2 | 0.713 |
DCAMKL2 |
0.714 | 0.011 | -3 | 0.744 |
MEKK3 |
0.714 | -0.071 | 1 | 0.752 |
TAO3 |
0.714 | 0.003 | 1 | 0.746 |
NEK5 |
0.713 | -0.009 | 1 | 0.806 |
MEKK1 |
0.713 | -0.059 | 1 | 0.777 |
BRSK2 |
0.713 | -0.083 | -3 | 0.752 |
QIK |
0.713 | -0.137 | -3 | 0.771 |
AKT1 |
0.712 | 0.051 | -3 | 0.685 |
MARK3 |
0.712 | -0.082 | 4 | 0.548 |
CK1E |
0.712 | -0.036 | -3 | 0.478 |
CHAK1 |
0.712 | -0.142 | 2 | 0.564 |
MAK |
0.711 | 0.112 | -2 | 0.728 |
ZAK |
0.711 | -0.067 | 1 | 0.745 |
MST3 |
0.711 | -0.021 | 2 | 0.704 |
SMMLCK |
0.711 | 0.012 | -3 | 0.784 |
BRAF |
0.710 | -0.045 | -4 | 0.731 |
ERK2 |
0.709 | -0.028 | 1 | 0.620 |
CDK16 |
0.709 | 0.012 | 1 | 0.528 |
MPSK1 |
0.709 | 0.010 | 1 | 0.765 |
SGK1 |
0.708 | 0.075 | -3 | 0.616 |
PAK5 |
0.708 | -0.002 | -2 | 0.649 |
WNK4 |
0.708 | -0.109 | -2 | 0.803 |
P70S6K |
0.708 | 0.005 | -3 | 0.697 |
CDK10 |
0.708 | 0.009 | 1 | 0.578 |
PKCT |
0.708 | -0.038 | 2 | 0.569 |
GAK |
0.707 | 0.055 | 1 | 0.801 |
MEK5 |
0.707 | -0.167 | 2 | 0.655 |
GCK |
0.707 | 0.059 | 1 | 0.722 |
MARK2 |
0.707 | -0.115 | 4 | 0.525 |
NEK11 |
0.706 | -0.046 | 1 | 0.757 |
MEKK2 |
0.706 | -0.100 | 2 | 0.624 |
GRK3 |
0.706 | -0.038 | -2 | 0.685 |
PKCI |
0.706 | -0.033 | 2 | 0.584 |
MST2 |
0.705 | 0.040 | 1 | 0.744 |
CAMK1D |
0.705 | 0.030 | -3 | 0.640 |
JNK1 |
0.705 | 0.002 | 1 | 0.561 |
PKCE |
0.705 | -0.002 | 2 | 0.583 |
NEK8 |
0.705 | -0.059 | 2 | 0.650 |
ERK7 |
0.705 | 0.008 | 2 | 0.442 |
CK1D |
0.704 | -0.020 | -3 | 0.427 |
PAK4 |
0.704 | -0.011 | -2 | 0.648 |
PDK1 |
0.704 | 0.007 | 1 | 0.819 |
SNRK |
0.704 | -0.161 | 2 | 0.517 |
CAMKK2 |
0.704 | -0.001 | -2 | 0.699 |
AKT3 |
0.704 | 0.057 | -3 | 0.624 |
LKB1 |
0.703 | 0.015 | -3 | 0.772 |
TTBK1 |
0.703 | -0.130 | 2 | 0.462 |
CK1G1 |
0.703 | -0.067 | -3 | 0.473 |
PINK1 |
0.703 | -0.132 | 1 | 0.782 |
EEF2K |
0.703 | -0.029 | 3 | 0.488 |
MARK1 |
0.702 | -0.121 | 4 | 0.570 |
ROCK2 |
0.702 | 0.075 | -3 | 0.745 |
MRCKA |
0.702 | 0.046 | -3 | 0.714 |
PHKG2 |
0.702 | -0.067 | -3 | 0.742 |
CAMKK1 |
0.701 | -0.064 | -2 | 0.699 |
DAPK3 |
0.701 | 0.025 | -3 | 0.753 |
DAPK1 |
0.701 | 0.031 | -3 | 0.749 |
PKN1 |
0.701 | 0.017 | -3 | 0.700 |
SLK |
0.700 | 0.024 | -2 | 0.734 |
CK1A2 |
0.700 | -0.043 | -3 | 0.429 |
BUB1 |
0.700 | 0.138 | -5 | 0.657 |
TAO2 |
0.699 | -0.083 | 2 | 0.684 |
MOK |
0.699 | 0.078 | 1 | 0.715 |
SBK |
0.699 | 0.082 | -3 | 0.568 |
IRAK4 |
0.698 | -0.167 | 1 | 0.771 |
TAK1 |
0.697 | -0.014 | 1 | 0.767 |
TNIK |
0.697 | -0.018 | 3 | 0.576 |
MRCKB |
0.697 | 0.033 | -3 | 0.707 |
CHK2 |
0.697 | 0.039 | -3 | 0.618 |
LOK |
0.695 | -0.010 | -2 | 0.749 |
MST1 |
0.695 | -0.004 | 1 | 0.737 |
HPK1 |
0.694 | -0.018 | 1 | 0.701 |
SSTK |
0.694 | -0.108 | 4 | 0.610 |
LRRK2 |
0.694 | -0.093 | 2 | 0.680 |
MAP3K15 |
0.693 | -0.069 | 1 | 0.742 |
NEK4 |
0.692 | -0.100 | 1 | 0.742 |
NEK1 |
0.692 | -0.050 | 1 | 0.775 |
YANK3 |
0.691 | -0.036 | 2 | 0.335 |
HGK |
0.691 | -0.079 | 3 | 0.557 |
MINK |
0.691 | -0.079 | 1 | 0.728 |
VRK1 |
0.691 | -0.097 | 2 | 0.679 |
CAMK1A |
0.690 | 0.019 | -3 | 0.626 |
MEKK6 |
0.690 | -0.103 | 1 | 0.747 |
CDK6 |
0.690 | -0.036 | 1 | 0.575 |
KHS1 |
0.690 | -0.017 | 1 | 0.719 |
PBK |
0.690 | 0.028 | 1 | 0.751 |
CDK4 |
0.689 | -0.028 | 1 | 0.557 |
STK33 |
0.689 | -0.114 | 2 | 0.488 |
KHS2 |
0.689 | -0.019 | 1 | 0.716 |
OSR1 |
0.688 | 0.033 | 2 | 0.632 |
PDHK3_TYR |
0.688 | 0.205 | 4 | 0.721 |
DMPK1 |
0.688 | 0.053 | -3 | 0.718 |
ROCK1 |
0.687 | 0.049 | -3 | 0.718 |
IRAK1 |
0.687 | -0.255 | -1 | 0.571 |
TTK |
0.686 | 0.024 | -2 | 0.871 |
MEK2 |
0.685 | -0.142 | 2 | 0.621 |
MAP2K4_TYR |
0.684 | 0.211 | -1 | 0.717 |
MAP2K6_TYR |
0.683 | 0.182 | -1 | 0.718 |
RIPK2 |
0.682 | -0.175 | 1 | 0.713 |
YSK1 |
0.682 | -0.097 | 2 | 0.633 |
CRIK |
0.682 | 0.041 | -3 | 0.685 |
PKG1 |
0.681 | -0.006 | -2 | 0.568 |
PDHK4_TYR |
0.681 | 0.135 | 2 | 0.750 |
NEK3 |
0.678 | -0.091 | 1 | 0.744 |
EPHB4 |
0.677 | 0.181 | -1 | 0.678 |
ABL2 |
0.677 | 0.201 | -1 | 0.601 |
BMPR2_TYR |
0.676 | 0.082 | -1 | 0.700 |
ALPHAK3 |
0.676 | -0.025 | -1 | 0.642 |
EPHA6 |
0.675 | 0.124 | -1 | 0.687 |
PDHK1_TYR |
0.675 | 0.071 | -1 | 0.717 |
TESK1_TYR |
0.675 | 0.021 | 3 | 0.588 |
MYO3B |
0.675 | -0.037 | 2 | 0.640 |
EPHA4 |
0.675 | 0.140 | 2 | 0.699 |
MAP2K7_TYR |
0.674 | -0.039 | 2 | 0.701 |
PKMYT1_TYR |
0.674 | -0.012 | 3 | 0.569 |
TAO1 |
0.671 | -0.066 | 1 | 0.691 |
ABL1 |
0.671 | 0.171 | -1 | 0.593 |
BIKE |
0.671 | 0.006 | 1 | 0.706 |
RET |
0.671 | 0.072 | 1 | 0.796 |
ASK1 |
0.670 | -0.092 | 1 | 0.733 |
DDR1 |
0.670 | 0.043 | 4 | 0.696 |
MST1R |
0.670 | 0.054 | 3 | 0.545 |
LIMK2_TYR |
0.669 | 0.021 | -3 | 0.821 |
HASPIN |
0.669 | -0.075 | -1 | 0.537 |
CSF1R |
0.668 | 0.053 | 3 | 0.526 |
CK1A |
0.668 | -0.057 | -3 | 0.344 |
PINK1_TYR |
0.667 | -0.102 | 1 | 0.813 |
JAK2 |
0.667 | 0.029 | 1 | 0.785 |
FGR |
0.666 | 0.038 | 1 | 0.826 |
EPHB2 |
0.666 | 0.122 | -1 | 0.656 |
EPHB3 |
0.665 | 0.111 | -1 | 0.648 |
MYO3A |
0.665 | -0.106 | 1 | 0.723 |
JAK3 |
0.665 | 0.069 | 1 | 0.786 |
FLT1 |
0.665 | 0.136 | -1 | 0.708 |
FGFR2 |
0.664 | 0.052 | 3 | 0.508 |
SRMS |
0.664 | 0.044 | 1 | 0.789 |
KIT |
0.663 | 0.054 | 3 | 0.520 |
TNK2 |
0.663 | -0.006 | 3 | 0.509 |
EPHB1 |
0.662 | 0.061 | 1 | 0.785 |
TYK2 |
0.662 | -0.082 | 1 | 0.797 |
KDR |
0.662 | 0.030 | 3 | 0.485 |
FER |
0.662 | -0.013 | 1 | 0.823 |
YES1 |
0.662 | -0.029 | -1 | 0.643 |
PTK2 |
0.661 | 0.139 | -1 | 0.672 |
EPHA5 |
0.661 | 0.127 | 2 | 0.683 |
LIMK1_TYR |
0.660 | -0.122 | 2 | 0.663 |
BLK |
0.660 | 0.026 | -1 | 0.612 |
MET |
0.660 | 0.066 | 3 | 0.542 |
INSRR |
0.660 | -0.004 | 3 | 0.446 |
EPHA3 |
0.659 | 0.062 | 2 | 0.653 |
TXK |
0.659 | 0.040 | 1 | 0.743 |
DDR2 |
0.659 | 0.072 | 3 | 0.447 |
ROS1 |
0.659 | -0.090 | 3 | 0.464 |
TYRO3 |
0.659 | -0.085 | 3 | 0.504 |
MERTK |
0.658 | 0.015 | 3 | 0.524 |
AAK1 |
0.657 | 0.035 | 1 | 0.610 |
EPHA7 |
0.657 | 0.036 | 2 | 0.682 |
FGFR3 |
0.657 | 0.041 | 3 | 0.484 |
HCK |
0.657 | -0.044 | -1 | 0.606 |
LCK |
0.657 | -0.005 | -1 | 0.607 |
FYN |
0.657 | 0.026 | -1 | 0.582 |
STLK3 |
0.656 | -0.130 | 1 | 0.702 |
FLT3 |
0.655 | -0.022 | 3 | 0.501 |
FGFR1 |
0.655 | -0.018 | 3 | 0.478 |
ITK |
0.655 | 0.001 | -1 | 0.584 |
EGFR |
0.655 | 0.089 | 1 | 0.747 |
PTK2B |
0.655 | 0.074 | -1 | 0.552 |
SYK |
0.654 | 0.137 | -1 | 0.631 |
NTRK1 |
0.654 | -0.003 | -1 | 0.655 |
YANK2 |
0.653 | -0.071 | 2 | 0.340 |
ERBB2 |
0.653 | 0.003 | 1 | 0.803 |
FLT4 |
0.653 | 0.002 | 3 | 0.473 |
TNK1 |
0.652 | -0.059 | 3 | 0.504 |
JAK1 |
0.652 | -0.056 | 1 | 0.740 |
TEK |
0.652 | -0.075 | 3 | 0.442 |
FGFR4 |
0.652 | 0.043 | -1 | 0.632 |
EPHA2 |
0.652 | 0.107 | -1 | 0.615 |
EPHA8 |
0.652 | 0.047 | -1 | 0.611 |
TNNI3K_TYR |
0.650 | -0.040 | 1 | 0.792 |
CK1G3 |
0.650 | -0.060 | -3 | 0.302 |
AXL |
0.650 | -0.073 | 3 | 0.504 |
PDGFRB |
0.649 | -0.092 | 3 | 0.505 |
EPHA1 |
0.649 | -0.014 | 3 | 0.517 |
FRK |
0.648 | -0.010 | -1 | 0.607 |
NTRK3 |
0.648 | -0.011 | -1 | 0.607 |
LTK |
0.648 | -0.082 | 3 | 0.471 |
NEK10_TYR |
0.647 | -0.064 | 1 | 0.655 |
BMX |
0.647 | -0.037 | -1 | 0.499 |
LYN |
0.646 | -0.060 | 3 | 0.437 |
PDGFRA |
0.645 | -0.106 | 3 | 0.510 |
SRC |
0.645 | -0.031 | -1 | 0.586 |
ZAP70 |
0.644 | 0.142 | -1 | 0.534 |
INSR |
0.644 | -0.057 | 3 | 0.437 |
CK1G2 |
0.644 | -0.040 | -3 | 0.391 |
TEC |
0.644 | -0.081 | -1 | 0.517 |
ALK |
0.643 | -0.115 | 3 | 0.431 |
WEE1_TYR |
0.643 | -0.106 | -1 | 0.563 |
CSK |
0.642 | -0.037 | 2 | 0.663 |
MATK |
0.642 | -0.039 | -1 | 0.552 |
NTRK2 |
0.642 | -0.083 | 3 | 0.464 |
ERBB4 |
0.641 | 0.060 | 1 | 0.739 |
BTK |
0.641 | -0.157 | -1 | 0.542 |
PTK6 |
0.639 | -0.157 | -1 | 0.545 |
IGF1R |
0.636 | -0.034 | 3 | 0.386 |
MUSK |
0.633 | -0.014 | 1 | 0.755 |
FES |
0.618 | -0.115 | -1 | 0.492 |