Motif 576 (n=240)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NI72 | NCF1B | S247 | ochoa | Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B) | May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}. |
| A8MVU1 | NCF1C | S222 | ochoa | Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C) | May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}. |
| H0YC42 | None | S171 | ochoa | Tumor protein D52 | None |
| O15031 | PLXNB2 | S1244 | ochoa | Plexin-B2 (MM1) | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:B2RXS4, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:15184888, ECO:0000269|PubMed:29100074, ECO:0000269|PubMed:32510170}. |
| O15169 | AXIN1 | S469 | psp | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O15534 | PER1 | S601 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43157 | PLXNB1 | S1535 | ochoa | Plexin-B1 (Semaphorin receptor SEP) | Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
| O43491 | EPB41L2 | S47 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43491 | EPB41L2 | S881 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43493 | TGOLN2 | S315 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O60271 | SPAG9 | S329 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75121 | MFAP3L | S360 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75152 | ZC3H11A | S533 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75153 | CLUH | S670 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75334 | PPFIA2 | S687 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
| O75665 | OFD1 | S899 | ochoa|psp | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75665 | OFD1 | S951 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75762 | TRPA1 | S35 | ochoa | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75914 | PAK3 | S435 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O94763 | URI1 | S449 | ochoa | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| O94880 | PHF14 | S91 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94880 | PHF14 | S147 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94888 | UBXN7 | S305 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O95239 | KIF4A | S1136 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95260 | ATE1 | S110 | ochoa | Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) | Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250|UniProtKB:Q9Z2A5, ECO:0000269|PubMed:34893540}. |
| O95279 | KCNK5 | S438 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
| O95551 | TDP2 | S95 | ochoa | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| O95674 | CDS2 | S41 | ochoa | Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) | Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}. |
| P04406 | GAPDH | S98 | psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P06703 | S100A6 | S46 | ochoa | Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6) | May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269|PubMed:22399290}. |
| P07476 | IVL | Y98 | ochoa | Involucrin | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| P07814 | EPRS1 | S739 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07951 | TPM2 | S245 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P10451 | SPP1 | S270 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11055 | MYH3 | S1479 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11217 | PYGM | S789 | ochoa | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}. |
| P12882 | MYH1 | S1482 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1832 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1478 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1480 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1481 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14598 | NCF1 | S246 | ochoa | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P15056 | BRAF | S76 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P16591 | FER | S408 | ochoa | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}. |
| P20810 | CAST | S297 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20810 | CAST | S379 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23193 | TCEA1 | S107 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P24593 | IGFBP5 | S125 | ochoa | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}. |
| P27635 | RPL10 | S54 | ochoa | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| P27816 | MAP4 | S330 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28066 | PSMA5 | S56 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P28290 | ITPRID2 | S366 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P31645 | SLC6A4 | S611 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P35442 | THBS2 | S238 | ochoa | Thrombospondin-2 | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}. |
| P35579 | MYH9 | S1628 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1161 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1635 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S1009 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40926 | MDH2 | S317 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P42696 | RBM34 | S167 | ochoa | RNA-binding protein 34 (RNA-binding motif protein 34) | None |
| P43307 | SSR1 | S247 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P43487 | RANBP1 | S21 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P46939 | UTRN | S295 | ochoa|psp | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46939 | UTRN | S784 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48637 | GSS | S149 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P49321 | NASP | S189 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49321 | NASP | S229 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P50579 | METAP2 | S60 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P51955 | NEK2 | S397 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P54132 | BLM | S282 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55265 | ADAR | S588 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P59923 | ZNF445 | S665 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P60709 | ACTB | T229 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61278 | SST | S74 | ochoa | Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] | [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}. |
| P62736 | ACTA2 | T231 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | T229 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | T230 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T231 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | T231 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78312 | FAM193A | S965 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78559 | MAP1A | S1654 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98164 | LRP2 | S4527 | psp | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000250|UniProtKB:C0HL13, ECO:0000250|UniProtKB:P98158, ECO:0000269|PubMed:15126248, ECO:0000269|PubMed:23825075}. |
| Q00987 | MDM2 | S395 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01484 | ANK2 | S2661 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02790 | FKBP4 | S258 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02952 | AKAP12 | S441 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S660 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q07817 | BCL2L1 | S49 | psp | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. |
| Q12802 | AKAP13 | S944 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | S1168 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S674 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12986 | NFX1 | S346 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13105 | ZBTB17 | S156 | ochoa | Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}. |
| Q13153 | PAK1 | S422 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13177 | PAK2 | S401 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q14151 | SAFB2 | S321 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14444 | CAPRIN1 | S307 | ochoa | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| Q14566 | MCM6 | S324 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14676 | MDC1 | S397 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15004 | PCLAF | S89 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15061 | WDR43 | S431 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15311 | RALBP1 | S463 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15424 | SAFB | S322 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15651 | HMGN3 | S78 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
| Q15652 | JMJD1C | S1628 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15785 | TOMM34 | S231 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16666 | IFI16 | S575 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q16891 | IMMT | S192 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2KHM9 | KIAA0753 | S772 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q2M1Z3 | ARHGAP31 | S1071 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2NKX8 | ERCC6L | S1036 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2TB10 | ZNF800 | S160 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q32MZ4 | LRRFIP1 | S613 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q5F1R6 | DNAJC21 | S302 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5H9R7 | PPP6R3 | S823 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5S007 | LRRK2 | S1292 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SW79 | CEP170 | S252 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T0F9 | CC2D1B | S613 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
| Q5T200 | ZC3H13 | S1433 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T4S7 | UBR4 | S4458 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5TB80 | CEP162 | S184 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q5VV52 | ZNF691 | S75 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5VZL5 | ZMYM4 | S1100 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6GYQ0 | RALGAPA1 | S711 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6IQ55 | TTBK2 | S794 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6KC79 | NIPBL | S1196 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P1M3 | LLGL2 | S680 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6P6B1 | ERICH5 | S354 | ochoa | Glutamate-rich protein 5 | None |
| Q6PKG0 | LARP1 | S215 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6S8J3 | POTEE | T929 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6UB99 | ANKRD11 | S429 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWE0 | LRSAM1 | S494 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q6ZVM7 | TOM1L2 | S457 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q7RTP6 | MICAL3 | S1321 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z3K6 | MIER3 | S123 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S960 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6Z7 | HUWE1 | S2362 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TI0 | TBC1D1 | S275 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UD5 | SLC9B2 | S49 | ochoa | Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) | Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:18508966, PubMed:22948142, PubMed:28154142, PubMed:36177733). Uses the proton gradient/membrane potential to extrude sodium (PubMed:22948142). Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (PubMed:22948142). May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). {ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142, ECO:0000269|PubMed:28154142, ECO:0000269|PubMed:36177733}. |
| Q86UP2 | KTN1 | S1313 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86W50 | METTL16 | S483 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86Y07 | VRK2 | S396 | ochoa | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) | Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}. |
| Q8IV38 | ANKMY2 | S419 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8IVF2 | AHNAK2 | S5515 | ochoa | Protein AHNAK2 | None |
| Q8IWA0 | WDR75 | S779 | ochoa | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8IWB9 | TEX2 | S408 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IY18 | SMC5 | S506 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8N884 | CGAS | S221 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8N9B5 | JMY | S723 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NFC6 | BOD1L1 | S277 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI08 | NCOA7 | S500 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TBZ6 | TRMT10A | S28 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
| Q8TCN5 | ZNF507 | S721 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TD16 | BICD2 | S102 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TD16 | BICD2 | S418 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TEM1 | NUP210 | S150 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TEV9 | SMCR8 | S638 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WU90 | ZC3H15 | S381 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q8WUM9 | SLC20A1 | S318 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WW12 | PCNP | S48 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q92576 | PHF3 | S1063 | ochoa | PHD finger protein 3 | None |
| Q92614 | MYO18A | S1942 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92783 | STAM | S191 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q92805 | GOLGA1 | S160 | ochoa | Golgin subfamily A member 1 (Golgin-97) | Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23 (PubMed:29084197, PubMed:38552021). Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers (PubMed:34969853). {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:38552021}.; FUNCTION: (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly. {ECO:0000269|PubMed:17276477}. |
| Q96AC1 | FERMT2 | S363 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96FV9 | THOC1 | S537 | ochoa | THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96G01 | BICD1 | S399 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96HH9 | GRAMD2B | S26 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96IQ7 | VSIG2 | S281 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96ME7 | ZNF512 | S537 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96PE5 | OPALIN | S88 | ochoa | Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10) | Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. {ECO:0000250|UniProtKB:Q7M750}. |
| Q96T88 | UHRF1 | S108 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99460 | PSMD1 | S305 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99590 | SCAF11 | S413 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S608 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99808 | SLC29A1 | S269 | ochoa | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BXL6 | CARD14 | S500 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BYF1 | ACE2 | S783 | psp | Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}. |
| Q9BZI7 | UPF3B | S416 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0C2 | TNKS1BP1 | S1248 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0G5 | NSRP1 | S146 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H252 | KCNH6 | S199 | ochoa | Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-gated potassium channel subunit Kv11.2) | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Activates even more slowly than KCNH2. {ECO:0000250|UniProtKB:O54853}. |
| Q9H2P0 | ADNP | S876 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H3D4 | TP63 | S68 | psp | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H4L7 | SMARCAD1 | S242 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H5H4 | ZNF768 | S160 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H6S1 | AZI2 | S83 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9H6Z4 | RANBP3 | S35 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9HA90 | EFCC1 | S394 | ochoa | EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48) | None |
| Q9NPC7 | MYNN | S539 | ochoa | Myoneurin (Zinc finger and BTB domain-containing protein 31) | None |
| Q9NQ84 | GPRC5C | S335 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQT8 | KIF13B | S858 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR30 | DDX21 | S458 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NSI6 | BRWD1 | S1276 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NSY1 | BMP2K | S1039 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NYF8 | BCLAF1 | S485 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P0K7 | RAI14 | S624 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P219 | CCDC88C | S953 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2I0 | CPSF2 | S419 | ochoa | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
| Q9UDY8 | MALT1 | S573 | psp | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}. |
| Q9UHB6 | LIMA1 | S326 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHL9 | GTF2IRD1 | S113 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UKL3 | CASP8AP2 | S1278 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S1834 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1482 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UL54 | TAOK2 | S486 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULF5 | SLC39A10 | S591 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9ULI0 | ATAD2B | S1321 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULI0 | ATAD2B | S1338 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULW0 | TPX2 | S285 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UNF1 | MAGED2 | S157 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UPM8 | AP4E1 | S847 | ochoa|psp | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPN9 | TRIM33 | S852 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UQ35 | SRRM2 | S1264 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y496 | KIF3A | S383 | ochoa | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}. |
| Q9Y5P4 | CERT1 | S315 | ochoa|psp | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y5Q9 | GTF3C3 | S43 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| Q9Y623 | MYH4 | S1482 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y666 | SLC12A7 | S62 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9C0C2 | TNKS1BP1 | S804 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P33176 | KIF5B | S527 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P35579 | MYH9 | S1154 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q04695 | KRT17 | S277 | Sugiyama | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}. |
| Q15643 | TRIP11 | S1001 | Sugiyama | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q92796 | DLG3 | S615 | Sugiyama | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| O14965 | AURKA | S226 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| Q7Z7G1 | CLNK | S331 | Sugiyama | Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) | An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QZE2}. |
| P48637 | GSS | Y395 | Sugiyama | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| O43615 | TIMM44 | Y104 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| P05771 | PRKCB | S311 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| Q9BRS2 | RIOK1 | S504 | Sugiyama | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}. |
| O75663 | TIPRL | S94 | Sugiyama | TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}. |
| P10809 | HSPD1 | S159 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| Q96ES7 | SGF29 | S31 | Sugiyama | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}. |
| Q9UPN9 | TRIM33 | S787 | Sugiyama | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9BW91 | NUDT9 | S238 | Sugiyama | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q8WUM4 | PDCD6IP | S454 | Sugiyama | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| P02533 | KRT14 | S321 | Sugiyama | Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}. |
| Q04695 | KRT17 | S290 | Sugiyama | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}. |
| Q14524 | SCN5A | S42 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.508901e-07 | 6.821 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.587563e-06 | 5.799 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.145561e-06 | 5.502 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.406525e-05 | 4.468 |
| R-HSA-390522 | Striated Muscle Contraction | 5.791285e-05 | 4.237 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.010704e-05 | 4.221 |
| R-HSA-397014 | Muscle contraction | 1.354602e-04 | 3.868 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.787192e-04 | 3.320 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.491505e-04 | 3.260 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.891995e-04 | 3.230 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.685410e-04 | 3.061 |
| R-HSA-373755 | Semaphorin interactions | 1.194231e-03 | 2.923 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.564783e-03 | 2.806 |
| R-HSA-428540 | Activation of RAC1 | 2.000717e-03 | 2.699 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.224600e-03 | 2.653 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.843876e-03 | 2.546 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.487138e-03 | 2.458 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.876977e-03 | 2.412 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.876977e-03 | 2.412 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.630861e-03 | 2.334 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.630861e-03 | 2.334 |
| R-HSA-983189 | Kinesins | 5.440118e-03 | 2.264 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.655759e-03 | 2.248 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.619553e-03 | 2.250 |
| R-HSA-373760 | L1CAM interactions | 5.852226e-03 | 2.233 |
| R-HSA-3928664 | Ephrin signaling | 6.558482e-03 | 2.183 |
| R-HSA-199991 | Membrane Trafficking | 7.098883e-03 | 2.149 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 8.225436e-03 | 2.085 |
| R-HSA-194138 | Signaling by VEGF | 8.592854e-03 | 2.066 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 9.699695e-03 | 2.013 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.388916e-03 | 2.027 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.699695e-03 | 2.013 |
| R-HSA-69481 | G2/M Checkpoints | 9.238110e-03 | 2.034 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.339620e-03 | 2.030 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.102745e-02 | 1.958 |
| R-HSA-9675108 | Nervous system development | 1.054690e-02 | 1.977 |
| R-HSA-446728 | Cell junction organization | 1.041767e-02 | 1.982 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.184832e-02 | 1.926 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.138691e-02 | 1.944 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.184832e-02 | 1.926 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 1.613911e-02 | 1.792 |
| R-HSA-196025 | Formation of annular gap junctions | 1.418508e-02 | 1.848 |
| R-HSA-190873 | Gap junction degradation | 1.670340e-02 | 1.777 |
| R-HSA-72187 | mRNA 3'-end processing | 1.734406e-02 | 1.761 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.663247e-02 | 1.779 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.461114e-02 | 1.835 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.641891e-02 | 1.785 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.418508e-02 | 1.848 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.383181e-02 | 1.859 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.672215e-02 | 1.777 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.418508e-02 | 1.848 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.504127e-02 | 1.823 |
| R-HSA-1640170 | Cell Cycle | 1.675345e-02 | 1.776 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.430694e-02 | 1.844 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.418508e-02 | 1.848 |
| R-HSA-202403 | TCR signaling | 1.562481e-02 | 1.806 |
| R-HSA-422475 | Axon guidance | 1.207672e-02 | 1.918 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.588330e-02 | 1.799 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.339909e-02 | 1.873 |
| R-HSA-418990 | Adherens junctions interactions | 1.700613e-02 | 1.769 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.885540e-02 | 1.725 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.939686e-02 | 1.712 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.044104e-02 | 1.689 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.044104e-02 | 1.689 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.315369e-02 | 1.635 |
| R-HSA-1500931 | Cell-Cell communication | 2.300620e-02 | 1.638 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.528429e-02 | 1.597 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.571256e-02 | 1.590 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 3.201873e-02 | 1.495 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.201873e-02 | 1.495 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.201873e-02 | 1.495 |
| R-HSA-169911 | Regulation of Apoptosis | 3.194461e-02 | 1.496 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.194461e-02 | 1.496 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 3.201873e-02 | 1.495 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.713786e-02 | 1.566 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.968253e-02 | 1.527 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.194461e-02 | 1.496 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.178373e-02 | 1.498 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 3.179908e-02 | 1.498 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.068778e-02 | 1.513 |
| R-HSA-74160 | Gene expression (Transcription) | 3.235318e-02 | 1.490 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.029673e-02 | 1.519 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.287547e-02 | 1.483 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.375609e-02 | 1.472 |
| R-HSA-421270 | Cell-cell junction organization | 3.489376e-02 | 1.457 |
| R-HSA-4641257 | Degradation of AXIN | 3.588333e-02 | 1.445 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.588333e-02 | 1.445 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.006004e-02 | 1.397 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.966992e-02 | 1.402 |
| R-HSA-69541 | Stabilization of p53 | 4.006004e-02 | 1.397 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.813962e-02 | 1.419 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.966992e-02 | 1.402 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.006004e-02 | 1.397 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 3.889535e-02 | 1.410 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.446848e-02 | 1.352 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.676432e-02 | 1.330 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.676432e-02 | 1.330 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 4.652949e-02 | 1.332 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.676432e-02 | 1.330 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.223667e-02 | 1.374 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.123484e-02 | 1.385 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.123484e-02 | 1.385 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.447159e-02 | 1.352 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.613717e-02 | 1.336 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 4.652949e-02 | 1.332 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.613717e-02 | 1.336 |
| R-HSA-202433 | Generation of second messenger molecules | 4.223667e-02 | 1.374 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.959033e-02 | 1.305 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 6.301605e-02 | 1.201 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 6.301605e-02 | 1.201 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 7.814186e-02 | 1.107 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.501991e-01 | 0.823 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.501991e-01 | 0.823 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.639225e-01 | 0.785 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.639225e-01 | 0.785 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 5.889912e-02 | 1.230 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 6.324769e-02 | 1.199 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.324769e-02 | 1.199 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 6.324769e-02 | 1.199 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 6.324769e-02 | 1.199 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.907107e-01 | 0.720 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.907107e-01 | 0.720 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 7.690497e-02 | 1.114 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.037824e-01 | 0.691 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.037824e-01 | 0.691 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.037824e-01 | 0.691 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.166437e-01 | 0.664 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.166437e-01 | 0.664 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.166437e-01 | 0.664 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 9.138893e-02 | 1.039 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.292981e-01 | 0.640 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.292981e-01 | 0.640 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.292981e-01 | 0.640 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.292981e-01 | 0.640 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.292981e-01 | 0.640 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.117995e-01 | 0.952 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.907630e-02 | 1.229 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.907630e-02 | 1.229 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.907630e-02 | 1.229 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.660523e-01 | 0.575 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 7.857489e-02 | 1.105 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.895797e-01 | 0.538 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.895797e-01 | 0.538 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.895797e-01 | 0.538 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.726753e-01 | 0.763 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.784568e-01 | 0.748 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.174650e-01 | 0.930 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.038232e-01 | 0.984 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.047136e-02 | 1.043 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.059848e-01 | 0.514 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.466138e-01 | 0.608 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.970604e-02 | 1.099 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.941004e-01 | 0.712 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 9.626793e-02 | 1.017 |
| R-HSA-3371568 | Attenuation phase | 1.784568e-01 | 0.748 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.907630e-02 | 1.229 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.443009e-01 | 0.841 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.168060e-01 | 0.664 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.555334e-01 | 0.808 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.220753e-01 | 0.913 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.292981e-01 | 0.640 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.224090e-01 | 0.912 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.721995e-02 | 1.012 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.878092e-02 | 1.231 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.387518e-01 | 0.858 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.362512e-01 | 0.866 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.332513e-01 | 0.875 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.332513e-01 | 0.875 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 7.857489e-02 | 1.105 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 7.857489e-02 | 1.105 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.959683e-01 | 0.708 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.726753e-01 | 0.763 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.513275e-01 | 0.820 |
| R-HSA-9907900 | Proteasome assembly | 2.077583e-01 | 0.682 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.494824e-01 | 0.603 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 9.638152e-02 | 1.016 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.076676e-01 | 0.968 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 2.779114e-01 | 0.556 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.245370e-01 | 0.905 |
| R-HSA-5620924 | Intraflagellar transport | 2.315372e-01 | 0.635 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.554754e-01 | 0.593 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.614712e-01 | 0.583 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.278027e-01 | 0.893 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.225095e-01 | 0.912 |
| R-HSA-5693538 | Homology Directed Repair | 1.697797e-01 | 0.770 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.485563e-01 | 0.828 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.241197e-01 | 0.906 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 6.301605e-02 | 1.201 |
| R-HSA-75102 | C6 deamination of adenosine | 6.301605e-02 | 1.201 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 7.814186e-02 | 1.107 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.501991e-01 | 0.823 |
| R-HSA-176974 | Unwinding of DNA | 1.774252e-01 | 0.751 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 2.037824e-01 | 0.691 |
| R-HSA-4839744 | Signaling by APC mutants | 2.037824e-01 | 0.691 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.166437e-01 | 0.664 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 9.138893e-02 | 1.039 |
| R-HSA-5689901 | Metalloprotease DUBs | 9.638152e-02 | 1.016 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.292981e-01 | 0.640 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.417488e-01 | 0.617 |
| R-HSA-68949 | Orc1 removal from chromatin | 7.563540e-02 | 1.121 |
| R-HSA-9678110 | Attachment and Entry | 2.779114e-01 | 0.556 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.779114e-01 | 0.556 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.443009e-01 | 0.841 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.669259e-01 | 0.777 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.196201e-01 | 0.658 |
| R-HSA-170968 | Frs2-mediated activation | 2.417488e-01 | 0.617 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.784568e-01 | 0.748 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 5.466005e-02 | 1.262 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.391247e-01 | 0.857 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.734645e-01 | 0.563 |
| R-HSA-169893 | Prolonged ERK activation events | 2.779114e-01 | 0.556 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 5.466005e-02 | 1.262 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 9.302442e-02 | 1.031 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.501991e-01 | 0.823 |
| R-HSA-9766229 | Degradation of CDH1 | 6.712051e-02 | 1.173 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.669259e-01 | 0.777 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.466263e-01 | 0.834 |
| R-HSA-912446 | Meiotic recombination | 2.494824e-01 | 0.603 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.941004e-01 | 0.712 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 8.460107e-02 | 1.073 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.081826e-02 | 1.042 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.174825e-01 | 0.930 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.663780e-02 | 1.116 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.712051e-02 | 1.173 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.712051e-02 | 1.173 |
| R-HSA-72312 | rRNA processing | 2.295611e-01 | 0.639 |
| R-HSA-437239 | Recycling pathway of L1 | 6.170424e-02 | 1.210 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.361374e-01 | 0.627 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.404537e-01 | 0.619 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 1.220753e-01 | 0.913 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.220753e-01 | 0.913 |
| R-HSA-75072 | mRNA Editing | 1.774252e-01 | 0.751 |
| R-HSA-170984 | ARMS-mediated activation | 1.774252e-01 | 0.751 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.907107e-01 | 0.720 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.907107e-01 | 0.720 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.278027e-01 | 0.893 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.332513e-01 | 0.875 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.498957e-01 | 0.824 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 8.768619e-02 | 1.057 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.901057e-01 | 0.721 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.255728e-01 | 0.647 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.554754e-01 | 0.593 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.900035e-01 | 0.721 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.533842e-01 | 0.596 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.574830e-01 | 0.589 |
| R-HSA-5617833 | Cilium Assembly | 1.281940e-01 | 0.892 |
| R-HSA-202424 | Downstream TCR signaling | 2.191123e-01 | 0.659 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.539991e-01 | 0.595 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.498957e-01 | 0.824 |
| R-HSA-4641258 | Degradation of DVL | 1.612110e-01 | 0.793 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.726753e-01 | 0.763 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.642695e-01 | 0.578 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.650271e-02 | 1.248 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.650271e-02 | 1.248 |
| R-HSA-182971 | EGFR downregulation | 1.224090e-01 | 0.912 |
| R-HSA-5689603 | UCH proteinases | 1.581184e-01 | 0.801 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.901057e-01 | 0.721 |
| R-HSA-844455 | The NLRP1 inflammasome | 7.814186e-02 | 1.107 |
| R-HSA-447038 | NrCAM interactions | 1.076676e-01 | 0.968 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.220753e-01 | 0.913 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.501991e-01 | 0.823 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.166437e-01 | 0.664 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.014499e-01 | 0.994 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 1.117995e-01 | 0.952 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.555334e-01 | 0.808 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.555334e-01 | 0.808 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.612110e-01 | 0.793 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.674680e-01 | 0.573 |
| R-HSA-8953854 | Metabolism of RNA | 6.810595e-02 | 1.167 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.958666e-02 | 1.099 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.332513e-01 | 0.875 |
| R-HSA-68886 | M Phase | 1.248286e-01 | 0.904 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.219352e-02 | 1.035 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.149870e-01 | 0.668 |
| R-HSA-73894 | DNA Repair | 2.801371e-01 | 0.553 |
| R-HSA-9758890 | Transport of RCbl within the body | 2.037824e-01 | 0.691 |
| R-HSA-5635838 | Activation of SMO | 2.779114e-01 | 0.556 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.536455e-01 | 0.596 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.536455e-01 | 0.596 |
| R-HSA-9664407 | Parasite infection | 2.536455e-01 | 0.596 |
| R-HSA-69239 | Synthesis of DNA | 3.059848e-01 | 0.514 |
| R-HSA-69275 | G2/M Transition | 1.201106e-01 | 0.920 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.543476e-01 | 0.812 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.078983e-01 | 0.682 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.241197e-01 | 0.906 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 5.889912e-02 | 1.230 |
| R-HSA-8982491 | Glycogen metabolism | 1.784568e-01 | 0.748 |
| R-HSA-9675135 | Diseases of DNA repair | 2.196201e-01 | 0.658 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.663780e-02 | 1.116 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.264115e-02 | 1.279 |
| R-HSA-164944 | Nef and signal transduction | 1.362512e-01 | 0.866 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.417488e-01 | 0.617 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.539991e-01 | 0.595 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.660523e-01 | 0.575 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.660523e-01 | 0.575 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.387518e-01 | 0.858 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.779114e-01 | 0.556 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.443009e-01 | 0.841 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.443009e-01 | 0.841 |
| R-HSA-1483148 | Synthesis of PG | 2.895797e-01 | 0.538 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.901057e-01 | 0.721 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.901057e-01 | 0.721 |
| R-HSA-190828 | Gap junction trafficking | 2.077583e-01 | 0.682 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.197129e-01 | 0.922 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.434938e-01 | 0.614 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.554754e-01 | 0.593 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.953364e-01 | 0.530 |
| R-HSA-1266695 | Interleukin-7 signaling | 9.138893e-02 | 1.039 |
| R-HSA-9909396 | Circadian clock | 9.594588e-02 | 1.018 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.090065e-01 | 0.963 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.639554e-01 | 0.785 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.660523e-01 | 0.575 |
| R-HSA-162906 | HIV Infection | 1.110225e-01 | 0.955 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.639225e-01 | 0.785 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.774252e-01 | 0.751 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.539991e-01 | 0.595 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.779114e-01 | 0.556 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.784568e-01 | 0.748 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.842677e-01 | 0.735 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.842677e-01 | 0.735 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.375115e-01 | 0.624 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.982192e-01 | 0.703 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.059848e-01 | 0.514 |
| R-HSA-9659379 | Sensory processing of sound | 1.698770e-01 | 0.770 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.255728e-01 | 0.647 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.460507e-01 | 0.835 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.014499e-01 | 0.994 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.539991e-01 | 0.595 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.281298e-01 | 0.892 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.018532e-01 | 0.695 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.077583e-01 | 0.682 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.136813e-01 | 0.670 |
| R-HSA-5688426 | Deubiquitination | 8.271934e-02 | 1.082 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.059848e-01 | 0.514 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.354246e-01 | 0.868 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.466138e-01 | 0.608 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 8.768619e-02 | 1.057 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.136813e-01 | 0.670 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.050440e-01 | 0.688 |
| R-HSA-177929 | Signaling by EGFR | 2.794589e-01 | 0.554 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.779114e-01 | 0.556 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.398412e-02 | 1.268 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 6.770117e-02 | 1.169 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.037824e-01 | 0.691 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.292981e-01 | 0.640 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.842677e-01 | 0.735 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.136813e-01 | 0.670 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.255728e-01 | 0.647 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.391247e-01 | 0.857 |
| R-HSA-180786 | Extension of Telomeres | 2.974153e-01 | 0.527 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 3.010601e-01 | 0.521 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.002169e-01 | 0.523 |
| R-HSA-2262752 | Cellular responses to stress | 2.502496e-01 | 0.602 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.669259e-01 | 0.777 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.322660e-01 | 0.879 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.895797e-01 | 0.538 |
| R-HSA-1266738 | Developmental Biology | 1.126624e-01 | 0.948 |
| R-HSA-212436 | Generic Transcription Pathway | 2.052944e-01 | 0.688 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.981375e-02 | 1.223 |
| R-HSA-109581 | Apoptosis | 7.577735e-02 | 1.120 |
| R-HSA-6807004 | Negative regulation of MET activity | 6.324769e-02 | 1.199 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 8.647600e-02 | 1.063 |
| R-HSA-4086400 | PCP/CE pathway | 1.659293e-01 | 0.780 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.494824e-01 | 0.603 |
| R-HSA-5357801 | Programmed Cell Death | 7.698299e-02 | 1.114 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 7.225505e-02 | 1.141 |
| R-HSA-435354 | Zinc transporters | 2.539991e-01 | 0.595 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.614712e-01 | 0.583 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.494824e-01 | 0.603 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.918516e-01 | 0.717 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 8.768619e-02 | 1.057 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.726753e-01 | 0.763 |
| R-HSA-351202 | Metabolism of polyamines | 3.033872e-01 | 0.518 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.443009e-01 | 0.841 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.947039e-01 | 0.531 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.438587e-02 | 1.191 |
| R-HSA-9824272 | Somitogenesis | 2.136813e-01 | 0.670 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.854498e-01 | 0.544 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.357954e-01 | 0.627 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.077583e-01 | 0.682 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.140495e-01 | 0.669 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.554754e-01 | 0.593 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.857277e-01 | 0.731 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.792899e-01 | 0.746 |
| R-HSA-1474244 | Extracellular matrix organization | 1.220376e-01 | 0.914 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.130036e-01 | 0.947 |
| R-HSA-6805567 | Keratinization | 3.079148e-01 | 0.512 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.093501e-01 | 0.510 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.093501e-01 | 0.510 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.104011e-01 | 0.508 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.123556e-01 | 0.505 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.123556e-01 | 0.505 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.123556e-01 | 0.505 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.123556e-01 | 0.505 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 3.123556e-01 | 0.505 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.148194e-01 | 0.502 |
| R-HSA-1268020 | Mitochondrial protein import | 3.153028e-01 | 0.501 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.153028e-01 | 0.501 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.153028e-01 | 0.501 |
| R-HSA-186797 | Signaling by PDGF | 3.153028e-01 | 0.501 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.181837e-01 | 0.497 |
| R-HSA-162587 | HIV Life Cycle | 3.184123e-01 | 0.497 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.212440e-01 | 0.493 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.212440e-01 | 0.493 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.212440e-01 | 0.493 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.220632e-01 | 0.492 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.234694e-01 | 0.490 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.234694e-01 | 0.490 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.259628e-01 | 0.487 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.280805e-01 | 0.484 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.280805e-01 | 0.484 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.330872e-01 | 0.477 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.330872e-01 | 0.477 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.344041e-01 | 0.476 |
| R-HSA-9629569 | Protein hydroxylation | 3.344041e-01 | 0.476 |
| R-HSA-445144 | Signal transduction by L1 | 3.344041e-01 | 0.476 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 3.389871e-01 | 0.470 |
| R-HSA-68882 | Mitotic Anaphase | 3.396609e-01 | 0.469 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.428526e-01 | 0.465 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.448709e-01 | 0.462 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.451628e-01 | 0.462 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.451628e-01 | 0.462 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.468816e-01 | 0.460 |
| R-HSA-5218859 | Regulated Necrosis | 3.507379e-01 | 0.455 |
| R-HSA-8951664 | Neddylation | 3.556388e-01 | 0.449 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.557483e-01 | 0.449 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.557483e-01 | 0.449 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.557483e-01 | 0.449 |
| R-HSA-9694614 | Attachment and Entry | 3.557483e-01 | 0.449 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.557483e-01 | 0.449 |
| R-HSA-9755088 | Ribavirin ADME | 3.557483e-01 | 0.449 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.557483e-01 | 0.449 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 3.557483e-01 | 0.449 |
| R-HSA-174403 | Glutathione synthesis and recycling | 3.557483e-01 | 0.449 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.624169e-01 | 0.441 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.661632e-01 | 0.436 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.661632e-01 | 0.436 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.661632e-01 | 0.436 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.661632e-01 | 0.436 |
| R-HSA-68875 | Mitotic Prophase | 3.721776e-01 | 0.429 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.740167e-01 | 0.427 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.740167e-01 | 0.427 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.740167e-01 | 0.427 |
| R-HSA-1280218 | Adaptive Immune System | 3.760164e-01 | 0.425 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.764105e-01 | 0.424 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.764105e-01 | 0.424 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.764105e-01 | 0.424 |
| R-HSA-3371556 | Cellular response to heat stress | 3.765645e-01 | 0.424 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.797848e-01 | 0.420 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.855305e-01 | 0.414 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.864927e-01 | 0.413 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.864927e-01 | 0.413 |
| R-HSA-429947 | Deadenylation of mRNA | 3.864927e-01 | 0.413 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.864927e-01 | 0.413 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.864927e-01 | 0.413 |
| R-HSA-380287 | Centrosome maturation | 3.912530e-01 | 0.408 |
| R-HSA-9620244 | Long-term potentiation | 3.964125e-01 | 0.402 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.964125e-01 | 0.402 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.964125e-01 | 0.402 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.964125e-01 | 0.402 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.969517e-01 | 0.401 |
| R-HSA-69206 | G1/S Transition | 3.983972e-01 | 0.400 |
| R-HSA-3295583 | TRP channels | 4.061725e-01 | 0.391 |
| R-HSA-525793 | Myogenesis | 4.061725e-01 | 0.391 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.061725e-01 | 0.391 |
| R-HSA-9845614 | Sphingolipid catabolism | 4.061725e-01 | 0.391 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.082746e-01 | 0.389 |
| R-HSA-5619084 | ABC transporter disorders | 4.082746e-01 | 0.389 |
| R-HSA-195721 | Signaling by WNT | 4.148298e-01 | 0.382 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.157752e-01 | 0.381 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.157752e-01 | 0.381 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.157752e-01 | 0.381 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.157752e-01 | 0.381 |
| R-HSA-8949613 | Cristae formation | 4.157752e-01 | 0.381 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.157752e-01 | 0.381 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.157752e-01 | 0.381 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.157752e-01 | 0.381 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.157752e-01 | 0.381 |
| R-HSA-264876 | Insulin processing | 4.157752e-01 | 0.381 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.170968e-01 | 0.380 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.194937e-01 | 0.377 |
| R-HSA-6806834 | Signaling by MET | 4.194937e-01 | 0.377 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.252233e-01 | 0.371 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.252233e-01 | 0.371 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.252233e-01 | 0.371 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 4.252233e-01 | 0.371 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.252233e-01 | 0.371 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.252233e-01 | 0.371 |
| R-HSA-5620971 | Pyroptosis | 4.252233e-01 | 0.371 |
| R-HSA-622312 | Inflammasomes | 4.252233e-01 | 0.371 |
| R-HSA-5334118 | DNA methylation | 4.345192e-01 | 0.362 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.345192e-01 | 0.362 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.345192e-01 | 0.362 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.361171e-01 | 0.360 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.416012e-01 | 0.355 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.436652e-01 | 0.353 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.436652e-01 | 0.353 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.436652e-01 | 0.353 |
| R-HSA-112311 | Neurotransmitter clearance | 4.436652e-01 | 0.353 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.436652e-01 | 0.353 |
| R-HSA-1500620 | Meiosis | 4.470560e-01 | 0.350 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.526639e-01 | 0.344 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.526639e-01 | 0.344 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.526639e-01 | 0.344 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.526639e-01 | 0.344 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.540521e-01 | 0.343 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.540521e-01 | 0.343 |
| R-HSA-69190 | DNA strand elongation | 4.615176e-01 | 0.336 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.615176e-01 | 0.336 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.632393e-01 | 0.334 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.685720e-01 | 0.329 |
| R-HSA-156902 | Peptide chain elongation | 4.685720e-01 | 0.329 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.702287e-01 | 0.328 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.702287e-01 | 0.328 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 4.702287e-01 | 0.328 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.702287e-01 | 0.328 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.702287e-01 | 0.328 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.702287e-01 | 0.328 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.702287e-01 | 0.328 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.702287e-01 | 0.328 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.702287e-01 | 0.328 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.738732e-01 | 0.324 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.787993e-01 | 0.320 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.787993e-01 | 0.320 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.787993e-01 | 0.320 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.787993e-01 | 0.320 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.843793e-01 | 0.315 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.843793e-01 | 0.315 |
| R-HSA-5673000 | RAF activation | 4.872318e-01 | 0.312 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.872318e-01 | 0.312 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.872318e-01 | 0.312 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 4.872318e-01 | 0.312 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.895836e-01 | 0.310 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.913159e-01 | 0.309 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.947550e-01 | 0.306 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.955284e-01 | 0.305 |
| R-HSA-187687 | Signalling to ERKs | 4.955284e-01 | 0.305 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.955284e-01 | 0.305 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.994289e-01 | 0.302 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.036912e-01 | 0.298 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.036912e-01 | 0.298 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.036912e-01 | 0.298 |
| R-HSA-3371511 | HSF1 activation | 5.036912e-01 | 0.298 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.049979e-01 | 0.297 |
| R-HSA-69242 | S Phase | 5.074763e-01 | 0.295 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.100688e-01 | 0.292 |
| R-HSA-9758941 | Gastrulation | 5.114749e-01 | 0.291 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 5.117225e-01 | 0.291 |
| R-HSA-1296072 | Voltage gated Potassium channels | 5.117225e-01 | 0.291 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.117225e-01 | 0.291 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.151057e-01 | 0.288 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.151057e-01 | 0.288 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.154564e-01 | 0.288 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.196242e-01 | 0.284 |
| R-HSA-157579 | Telomere Maintenance | 5.250766e-01 | 0.280 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.258481e-01 | 0.279 |
| R-HSA-69306 | DNA Replication | 5.272965e-01 | 0.278 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.273986e-01 | 0.278 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.273986e-01 | 0.278 |
| R-HSA-9648002 | RAS processing | 5.273986e-01 | 0.278 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.312077e-01 | 0.275 |
| R-HSA-3214847 | HATs acetylate histones | 5.349090e-01 | 0.272 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.350477e-01 | 0.272 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.350477e-01 | 0.272 |
| R-HSA-167169 | HIV Transcription Elongation | 5.350477e-01 | 0.272 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.350477e-01 | 0.272 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.351008e-01 | 0.272 |
| R-HSA-70171 | Glycolysis | 5.397729e-01 | 0.268 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.397729e-01 | 0.268 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.425734e-01 | 0.266 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.425734e-01 | 0.266 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.425734e-01 | 0.266 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.425734e-01 | 0.266 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.425734e-01 | 0.266 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.446016e-01 | 0.264 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.446016e-01 | 0.264 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.493950e-01 | 0.260 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.499777e-01 | 0.260 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.499777e-01 | 0.260 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.499777e-01 | 0.260 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.499777e-01 | 0.260 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.499777e-01 | 0.260 |
| R-HSA-192823 | Viral mRNA Translation | 5.541530e-01 | 0.256 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.572627e-01 | 0.254 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.572627e-01 | 0.254 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.588755e-01 | 0.253 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.644301e-01 | 0.248 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.644301e-01 | 0.248 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.682137e-01 | 0.245 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.692983e-01 | 0.245 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.692983e-01 | 0.245 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 5.714820e-01 | 0.243 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.784201e-01 | 0.238 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.784201e-01 | 0.238 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.784201e-01 | 0.238 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.819527e-01 | 0.235 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.819527e-01 | 0.235 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.819527e-01 | 0.235 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.852463e-01 | 0.233 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.852463e-01 | 0.233 |
| R-HSA-75153 | Apoptotic execution phase | 5.852463e-01 | 0.233 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.852463e-01 | 0.233 |
| R-HSA-72306 | tRNA processing | 5.948049e-01 | 0.226 |
| R-HSA-70263 | Gluconeogenesis | 5.985702e-01 | 0.223 |
| R-HSA-425410 | Metal ion SLC transporters | 5.985702e-01 | 0.223 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.997686e-01 | 0.222 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.019109e-01 | 0.220 |
| R-HSA-73893 | DNA Damage Bypass | 6.050713e-01 | 0.218 |
| R-HSA-9748787 | Azathioprine ADME | 6.114676e-01 | 0.214 |
| R-HSA-157118 | Signaling by NOTCH | 6.120160e-01 | 0.213 |
| R-HSA-2514856 | The phototransduction cascade | 6.177606e-01 | 0.209 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.212298e-01 | 0.207 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.239521e-01 | 0.205 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.239521e-01 | 0.205 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.239521e-01 | 0.205 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.254144e-01 | 0.204 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.254144e-01 | 0.204 |
| R-HSA-168255 | Influenza Infection | 6.261323e-01 | 0.203 |
| R-HSA-70326 | Glucose metabolism | 6.295632e-01 | 0.201 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.295632e-01 | 0.201 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.300437e-01 | 0.201 |
| R-HSA-1221632 | Meiotic synapsis | 6.300437e-01 | 0.201 |
| R-HSA-597592 | Post-translational protein modification | 6.357992e-01 | 0.197 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.377538e-01 | 0.195 |
| R-HSA-418597 | G alpha (z) signalling events | 6.419336e-01 | 0.193 |
| R-HSA-73886 | Chromosome Maintenance | 6.458021e-01 | 0.190 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.477350e-01 | 0.189 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.477350e-01 | 0.189 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.477350e-01 | 0.189 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.477350e-01 | 0.189 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.477350e-01 | 0.189 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.537089e-01 | 0.185 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.575122e-01 | 0.182 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.590583e-01 | 0.181 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.590583e-01 | 0.181 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.645833e-01 | 0.177 |
| R-HSA-191859 | snRNP Assembly | 6.645833e-01 | 0.177 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.645833e-01 | 0.177 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.700190e-01 | 0.174 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.700190e-01 | 0.174 |
| R-HSA-379724 | tRNA Aminoacylation | 6.700190e-01 | 0.174 |
| R-HSA-156590 | Glutathione conjugation | 6.700190e-01 | 0.174 |
| R-HSA-68877 | Mitotic Prometaphase | 6.714873e-01 | 0.173 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.745680e-01 | 0.171 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.753670e-01 | 0.170 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.806287e-01 | 0.167 |
| R-HSA-162582 | Signal Transduction | 6.834878e-01 | 0.165 |
| R-HSA-112316 | Neuronal System | 6.849708e-01 | 0.164 |
| R-HSA-8848021 | Signaling by PTK6 | 6.858054e-01 | 0.164 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.858054e-01 | 0.164 |
| R-HSA-1474165 | Reproduction | 6.875600e-01 | 0.163 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.908985e-01 | 0.161 |
| R-HSA-5576891 | Cardiac conduction | 6.911491e-01 | 0.160 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.926073e-01 | 0.160 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.947043e-01 | 0.158 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.982258e-01 | 0.156 |
| R-HSA-72172 | mRNA Splicing | 7.070594e-01 | 0.151 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.104615e-01 | 0.148 |
| R-HSA-167172 | Transcription of the HIV genome | 7.104615e-01 | 0.148 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.197754e-01 | 0.143 |
| R-HSA-6807070 | PTEN Regulation | 7.219446e-01 | 0.141 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.228831e-01 | 0.141 |
| R-HSA-9658195 | Leishmania infection | 7.228831e-01 | 0.141 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.243198e-01 | 0.140 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 7.243198e-01 | 0.140 |
| R-HSA-975634 | Retinoid metabolism and transport | 7.243198e-01 | 0.140 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.243198e-01 | 0.140 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.287908e-01 | 0.137 |
| R-HSA-74259 | Purine catabolism | 7.287908e-01 | 0.137 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.290959e-01 | 0.137 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.331896e-01 | 0.135 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.347819e-01 | 0.134 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.375172e-01 | 0.132 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.375172e-01 | 0.132 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.375172e-01 | 0.132 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.417750e-01 | 0.130 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.417750e-01 | 0.130 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.417750e-01 | 0.130 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.417750e-01 | 0.130 |
| R-HSA-72766 | Translation | 7.422833e-01 | 0.129 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.459639e-01 | 0.127 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.501181e-01 | 0.125 |
| R-HSA-2187338 | Visual phototransduction | 7.501181e-01 | 0.125 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.541398e-01 | 0.123 |
| R-HSA-216083 | Integrin cell surface interactions | 7.541398e-01 | 0.123 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.581289e-01 | 0.120 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.589504e-01 | 0.120 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.620535e-01 | 0.118 |
| R-HSA-9833482 | PKR-mediated signaling | 7.620535e-01 | 0.118 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.620535e-01 | 0.118 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.646881e-01 | 0.117 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 7.659147e-01 | 0.116 |
| R-HSA-9609507 | Protein localization | 7.675124e-01 | 0.115 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.703072e-01 | 0.113 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.771277e-01 | 0.110 |
| R-HSA-9711097 | Cellular response to starvation | 7.811967e-01 | 0.107 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.830138e-01 | 0.106 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.843041e-01 | 0.106 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.843041e-01 | 0.106 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.878055e-01 | 0.104 |
| R-HSA-8939211 | ESR-mediated signaling | 7.896367e-01 | 0.103 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.912503e-01 | 0.102 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.912503e-01 | 0.102 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.946394e-01 | 0.100 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.012540e-01 | 0.096 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.105144e-01 | 0.091 |
| R-HSA-391251 | Protein folding | 8.107800e-01 | 0.091 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.107800e-01 | 0.091 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.117081e-01 | 0.091 |
| R-HSA-4839726 | Chromatin organization | 8.144744e-01 | 0.089 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.247818e-01 | 0.084 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.256565e-01 | 0.083 |
| R-HSA-1296071 | Potassium Channels | 8.256565e-01 | 0.083 |
| R-HSA-449147 | Signaling by Interleukins | 8.277839e-01 | 0.082 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.284889e-01 | 0.082 |
| R-HSA-190236 | Signaling by FGFR | 8.312755e-01 | 0.080 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.340169e-01 | 0.079 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.367140e-01 | 0.077 |
| R-HSA-168249 | Innate Immune System | 8.404726e-01 | 0.075 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.419779e-01 | 0.075 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.419779e-01 | 0.075 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.419779e-01 | 0.075 |
| R-HSA-109582 | Hemostasis | 8.472251e-01 | 0.072 |
| R-HSA-392499 | Metabolism of proteins | 8.518413e-01 | 0.070 |
| R-HSA-983712 | Ion channel transport | 8.531289e-01 | 0.069 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.544098e-01 | 0.068 |
| R-HSA-211000 | Gene Silencing by RNA | 8.567767e-01 | 0.067 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.586340e-01 | 0.066 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 8.613961e-01 | 0.065 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.680484e-01 | 0.061 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.723056e-01 | 0.059 |
| R-HSA-428157 | Sphingolipid metabolism | 8.740392e-01 | 0.058 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.756524e-01 | 0.058 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.764259e-01 | 0.057 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.823594e-01 | 0.054 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.842735e-01 | 0.053 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.878953e-01 | 0.052 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 8.898315e-01 | 0.051 |
| R-HSA-6798695 | Neutrophil degranulation | 8.904869e-01 | 0.050 |
| R-HSA-114608 | Platelet degranulation | 9.017877e-01 | 0.045 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.033868e-01 | 0.044 |
| R-HSA-8956319 | Nucleotide catabolism | 9.049599e-01 | 0.043 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.126247e-01 | 0.040 |
| R-HSA-5173105 | O-linked glycosylation | 9.193534e-01 | 0.037 |
| R-HSA-166520 | Signaling by NTRKs | 9.337871e-01 | 0.030 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.350319e-01 | 0.029 |
| R-HSA-9824446 | Viral Infection Pathways | 9.375757e-01 | 0.028 |
| R-HSA-73887 | Death Receptor Signaling | 9.400076e-01 | 0.027 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.402394e-01 | 0.027 |
| R-HSA-9610379 | HCMV Late Events | 9.428959e-01 | 0.026 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.456457e-01 | 0.024 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.495179e-01 | 0.022 |
| R-HSA-5619102 | SLC transporter disorders | 9.515596e-01 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.520465e-01 | 0.021 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.529901e-01 | 0.021 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.568323e-01 | 0.019 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.568323e-01 | 0.019 |
| R-HSA-9679506 | SARS-CoV Infections | 9.589731e-01 | 0.018 |
| R-HSA-611105 | Respiratory electron transport | 9.602446e-01 | 0.018 |
| R-HSA-913531 | Interferon Signaling | 9.609570e-01 | 0.017 |
| R-HSA-2559583 | Cellular Senescence | 9.615330e-01 | 0.017 |
| R-HSA-3781865 | Diseases of glycosylation | 9.639864e-01 | 0.016 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.641969e-01 | 0.016 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.651540e-01 | 0.015 |
| R-HSA-168256 | Immune System | 9.663988e-01 | 0.015 |
| R-HSA-9609690 | HCMV Early Events | 9.704499e-01 | 0.013 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.710286e-01 | 0.013 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.736721e-01 | 0.012 |
| R-HSA-5663205 | Infectious disease | 9.747310e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.792825e-01 | 0.009 |
| R-HSA-9748784 | Drug ADME | 9.797828e-01 | 0.009 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.834185e-01 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 9.839751e-01 | 0.007 |
| R-HSA-15869 | Metabolism of nucleotides | 9.849842e-01 | 0.007 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.857108e-01 | 0.006 |
| R-HSA-9609646 | HCMV Infection | 9.880881e-01 | 0.005 |
| R-HSA-1643685 | Disease | 9.903257e-01 | 0.004 |
| R-HSA-1483257 | Phospholipid metabolism | 9.943490e-01 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.943670e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.947661e-01 | 0.002 |
| R-HSA-8957322 | Metabolism of steroids | 9.965092e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.966748e-01 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.973690e-01 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.982063e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.988232e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.989306e-01 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 9.991394e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.998771e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999596e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999934e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.804 | 0.140 | 2 | 0.860 |
CLK3 |
0.796 | 0.112 | 1 | 0.820 |
MOS |
0.790 | 0.068 | 1 | 0.882 |
CDC7 |
0.790 | 0.026 | 1 | 0.876 |
DSTYK |
0.790 | 0.110 | 2 | 0.885 |
FAM20C |
0.787 | 0.154 | 2 | 0.716 |
BMPR1B |
0.786 | 0.166 | 1 | 0.833 |
PIM3 |
0.786 | 0.021 | -3 | 0.867 |
PRPK |
0.784 | -0.045 | -1 | 0.838 |
RAF1 |
0.783 | 0.038 | 1 | 0.816 |
CAMK2G |
0.782 | 0.042 | 2 | 0.806 |
NDR2 |
0.782 | -0.012 | -3 | 0.863 |
IKKB |
0.781 | 0.030 | -2 | 0.713 |
GRK1 |
0.780 | 0.121 | -2 | 0.748 |
CAMK1B |
0.780 | -0.007 | -3 | 0.885 |
IKKA |
0.780 | 0.156 | -2 | 0.694 |
BMPR2 |
0.779 | -0.004 | -2 | 0.865 |
ATR |
0.777 | -0.001 | 1 | 0.804 |
PRKD1 |
0.777 | -0.019 | -3 | 0.853 |
GRK6 |
0.777 | 0.077 | 1 | 0.829 |
MTOR |
0.777 | -0.050 | 1 | 0.751 |
ERK5 |
0.777 | 0.030 | 1 | 0.841 |
CDKL1 |
0.777 | 0.012 | -3 | 0.832 |
LATS1 |
0.776 | 0.060 | -3 | 0.876 |
PIM1 |
0.776 | 0.037 | -3 | 0.823 |
PKN3 |
0.776 | -0.002 | -3 | 0.855 |
LATS2 |
0.776 | -0.029 | -5 | 0.106 |
GCN2 |
0.776 | -0.059 | 2 | 0.789 |
TGFBR1 |
0.775 | 0.114 | -2 | 0.817 |
NLK |
0.775 | -0.037 | 1 | 0.793 |
SKMLCK |
0.775 | 0.007 | -2 | 0.837 |
TBK1 |
0.775 | -0.023 | 1 | 0.702 |
BMPR1A |
0.774 | 0.166 | 1 | 0.814 |
RSK2 |
0.774 | 0.011 | -3 | 0.812 |
NEK6 |
0.774 | -0.002 | -2 | 0.833 |
PDHK4 |
0.774 | -0.155 | 1 | 0.819 |
ALK2 |
0.773 | 0.128 | -2 | 0.823 |
CAMK2B |
0.773 | 0.056 | 2 | 0.796 |
NEK7 |
0.773 | 0.008 | -3 | 0.821 |
IKKE |
0.772 | -0.011 | 1 | 0.697 |
ULK2 |
0.772 | -0.075 | 2 | 0.776 |
ATM |
0.772 | 0.038 | 1 | 0.750 |
PRKD2 |
0.771 | -0.006 | -3 | 0.811 |
MLK1 |
0.771 | -0.010 | 2 | 0.812 |
MAPKAPK2 |
0.771 | 0.004 | -3 | 0.786 |
NIK |
0.770 | -0.077 | -3 | 0.895 |
GRK7 |
0.770 | 0.127 | 1 | 0.753 |
CDKL5 |
0.770 | 0.006 | -3 | 0.825 |
CAMLCK |
0.770 | -0.023 | -2 | 0.840 |
TGFBR2 |
0.770 | -0.041 | -2 | 0.802 |
ACVR2B |
0.770 | 0.120 | -2 | 0.796 |
NDR1 |
0.770 | -0.052 | -3 | 0.865 |
GRK5 |
0.769 | -0.050 | -3 | 0.846 |
CHAK2 |
0.769 | 0.004 | -1 | 0.815 |
SRPK1 |
0.769 | 0.023 | -3 | 0.787 |
TSSK2 |
0.769 | -0.067 | -5 | 0.097 |
DAPK2 |
0.769 | -0.038 | -3 | 0.883 |
PKCD |
0.768 | 0.011 | 2 | 0.784 |
P70S6KB |
0.768 | -0.013 | -3 | 0.833 |
ACVR2A |
0.768 | 0.090 | -2 | 0.790 |
MST4 |
0.767 | -0.040 | 2 | 0.837 |
ALK4 |
0.767 | 0.034 | -2 | 0.833 |
CAMK2D |
0.767 | -0.054 | -3 | 0.861 |
KIS |
0.767 | 0.017 | 1 | 0.672 |
MAPKAPK3 |
0.767 | -0.060 | -3 | 0.821 |
PDHK1 |
0.767 | -0.153 | 1 | 0.805 |
HUNK |
0.767 | -0.069 | 2 | 0.779 |
PLK1 |
0.766 | 0.027 | -2 | 0.790 |
NUAK2 |
0.766 | -0.072 | -3 | 0.868 |
CAMK2A |
0.766 | 0.011 | 2 | 0.796 |
P90RSK |
0.766 | -0.027 | -3 | 0.816 |
ICK |
0.765 | -0.001 | -3 | 0.862 |
GRK4 |
0.765 | 0.021 | -2 | 0.790 |
RIPK3 |
0.765 | -0.106 | 3 | 0.768 |
PKN2 |
0.765 | -0.052 | -3 | 0.859 |
CLK2 |
0.764 | 0.076 | -3 | 0.796 |
ULK1 |
0.764 | -0.079 | -3 | 0.810 |
WNK1 |
0.764 | -0.096 | -2 | 0.845 |
RSK3 |
0.763 | -0.029 | -3 | 0.813 |
TSSK1 |
0.763 | -0.051 | -3 | 0.890 |
PKACG |
0.763 | -0.005 | -2 | 0.780 |
DLK |
0.763 | -0.051 | 1 | 0.795 |
RSK4 |
0.763 | 0.025 | -3 | 0.782 |
MARK4 |
0.762 | -0.074 | 4 | 0.697 |
AMPKA1 |
0.762 | -0.088 | -3 | 0.877 |
AURC |
0.761 | 0.004 | -2 | 0.693 |
PRKX |
0.761 | 0.078 | -3 | 0.728 |
ANKRD3 |
0.760 | -0.093 | 1 | 0.812 |
PKR |
0.760 | -0.013 | 1 | 0.802 |
SRPK2 |
0.760 | 0.020 | -3 | 0.722 |
PKACB |
0.760 | 0.039 | -2 | 0.716 |
CLK1 |
0.759 | 0.027 | -3 | 0.789 |
PLK3 |
0.759 | 0.033 | 2 | 0.763 |
CLK4 |
0.759 | 0.016 | -3 | 0.808 |
MLK3 |
0.759 | -0.006 | 2 | 0.746 |
NEK9 |
0.759 | -0.104 | 2 | 0.825 |
WNK3 |
0.759 | -0.135 | 1 | 0.770 |
CAMK4 |
0.759 | -0.078 | -3 | 0.850 |
MLK4 |
0.759 | 0.042 | 2 | 0.728 |
CDK8 |
0.759 | 0.004 | 1 | 0.631 |
BCKDK |
0.758 | -0.120 | -1 | 0.765 |
MSK2 |
0.758 | -0.009 | -3 | 0.784 |
MSK1 |
0.758 | 0.016 | -3 | 0.793 |
CHK1 |
0.758 | -0.075 | -3 | 0.875 |
CDK1 |
0.758 | 0.036 | 1 | 0.612 |
HIPK4 |
0.758 | -0.040 | 1 | 0.750 |
PRKD3 |
0.757 | -0.027 | -3 | 0.785 |
SRPK3 |
0.757 | 0.006 | -3 | 0.758 |
AURA |
0.756 | 0.026 | -2 | 0.640 |
CK2A2 |
0.756 | 0.117 | 1 | 0.769 |
MEK1 |
0.756 | -0.068 | 2 | 0.836 |
PAK1 |
0.755 | -0.030 | -2 | 0.764 |
MASTL |
0.755 | -0.219 | -2 | 0.774 |
DNAPK |
0.754 | 0.007 | 1 | 0.679 |
PKCB |
0.754 | -0.026 | 2 | 0.745 |
DYRK2 |
0.754 | -0.004 | 1 | 0.675 |
JNK3 |
0.754 | 0.021 | 1 | 0.632 |
NIM1 |
0.754 | -0.088 | 3 | 0.785 |
IRE2 |
0.754 | -0.049 | 2 | 0.742 |
BRAF |
0.754 | 0.023 | -4 | 0.832 |
AMPKA2 |
0.753 | -0.086 | -3 | 0.851 |
MLK2 |
0.753 | -0.137 | 2 | 0.816 |
CDK5 |
0.753 | 0.011 | 1 | 0.665 |
JNK2 |
0.752 | 0.014 | 1 | 0.598 |
CDK19 |
0.752 | -0.002 | 1 | 0.595 |
RIPK1 |
0.752 | -0.165 | 1 | 0.764 |
AURB |
0.752 | -0.015 | -2 | 0.682 |
PKCA |
0.752 | -0.039 | 2 | 0.732 |
PKCG |
0.751 | -0.051 | 2 | 0.733 |
GRK2 |
0.751 | -0.001 | -2 | 0.692 |
P38A |
0.751 | -0.000 | 1 | 0.696 |
NUAK1 |
0.751 | -0.072 | -3 | 0.831 |
IRE1 |
0.751 | -0.103 | 1 | 0.748 |
YSK4 |
0.751 | -0.089 | 1 | 0.734 |
TLK2 |
0.751 | 0.005 | 1 | 0.750 |
TTBK2 |
0.751 | -0.118 | 2 | 0.687 |
PIM2 |
0.751 | -0.018 | -3 | 0.789 |
MYLK4 |
0.750 | -0.034 | -2 | 0.776 |
MELK |
0.750 | -0.082 | -3 | 0.838 |
PKCH |
0.750 | -0.043 | 2 | 0.727 |
QSK |
0.750 | -0.054 | 4 | 0.664 |
SGK3 |
0.750 | -0.007 | -3 | 0.802 |
PAK3 |
0.750 | -0.076 | -2 | 0.767 |
PINK1 |
0.749 | -0.010 | 1 | 0.769 |
CDK2 |
0.749 | 0.009 | 1 | 0.685 |
PKG2 |
0.749 | -0.008 | -2 | 0.732 |
VRK2 |
0.749 | -0.191 | 1 | 0.829 |
AKT2 |
0.749 | 0.005 | -3 | 0.735 |
DRAK1 |
0.748 | -0.032 | 1 | 0.750 |
ERK1 |
0.748 | 0.007 | 1 | 0.620 |
MNK2 |
0.748 | -0.069 | -2 | 0.795 |
PASK |
0.748 | 0.011 | -3 | 0.868 |
SMG1 |
0.748 | -0.061 | 1 | 0.752 |
P38B |
0.748 | 0.007 | 1 | 0.640 |
NEK2 |
0.748 | -0.102 | 2 | 0.804 |
CHAK1 |
0.747 | -0.082 | 2 | 0.750 |
MEKK3 |
0.747 | -0.076 | 1 | 0.764 |
SIK |
0.747 | -0.044 | -3 | 0.803 |
MARK2 |
0.746 | -0.046 | 4 | 0.591 |
GSK3A |
0.746 | 0.023 | 4 | 0.455 |
CDK18 |
0.746 | -0.010 | 1 | 0.579 |
PKACA |
0.746 | 0.030 | -2 | 0.682 |
PLK2 |
0.746 | 0.094 | -3 | 0.862 |
MEKK1 |
0.745 | -0.048 | 1 | 0.760 |
MNK1 |
0.745 | -0.052 | -2 | 0.808 |
SMMLCK |
0.745 | -0.038 | -3 | 0.843 |
PKCZ |
0.745 | -0.069 | 2 | 0.774 |
MEKK2 |
0.745 | -0.032 | 2 | 0.800 |
CDK13 |
0.745 | -0.028 | 1 | 0.621 |
P38G |
0.745 | 0.009 | 1 | 0.526 |
CDK3 |
0.745 | 0.036 | 1 | 0.551 |
CDK7 |
0.745 | -0.057 | 1 | 0.649 |
ERK2 |
0.744 | -0.019 | 1 | 0.652 |
GSK3B |
0.744 | -0.006 | 4 | 0.442 |
PRP4 |
0.744 | -0.002 | -3 | 0.764 |
BRSK1 |
0.744 | -0.070 | -3 | 0.831 |
QIK |
0.743 | -0.143 | -3 | 0.850 |
DCAMKL1 |
0.743 | -0.050 | -3 | 0.828 |
MAPKAPK5 |
0.743 | -0.083 | -3 | 0.762 |
CK2A1 |
0.743 | 0.084 | 1 | 0.746 |
CAMK1G |
0.743 | -0.057 | -3 | 0.796 |
PHKG1 |
0.743 | -0.113 | -3 | 0.856 |
PAK2 |
0.743 | -0.076 | -2 | 0.745 |
HIPK1 |
0.742 | -0.014 | 1 | 0.684 |
PERK |
0.742 | -0.116 | -2 | 0.819 |
GAK |
0.742 | 0.014 | 1 | 0.806 |
PAK6 |
0.742 | -0.028 | -2 | 0.689 |
MARK3 |
0.742 | -0.063 | 4 | 0.629 |
TLK1 |
0.742 | -0.071 | -2 | 0.818 |
TAO3 |
0.742 | 0.005 | 1 | 0.754 |
HIPK2 |
0.742 | 0.006 | 1 | 0.583 |
HRI |
0.741 | -0.145 | -2 | 0.831 |
CDK17 |
0.741 | -0.014 | 1 | 0.529 |
NEK5 |
0.741 | -0.091 | 1 | 0.787 |
MEK5 |
0.740 | -0.179 | 2 | 0.820 |
DYRK1A |
0.740 | -0.015 | 1 | 0.703 |
CAMK1D |
0.739 | -0.027 | -3 | 0.742 |
DYRK4 |
0.739 | 0.005 | 1 | 0.603 |
MARK1 |
0.739 | -0.075 | 4 | 0.651 |
DAPK3 |
0.739 | -0.002 | -3 | 0.834 |
GRK3 |
0.738 | -0.005 | -2 | 0.647 |
SSTK |
0.738 | -0.082 | 4 | 0.666 |
DCAMKL2 |
0.738 | -0.061 | -3 | 0.848 |
ZAK |
0.738 | -0.112 | 1 | 0.731 |
P70S6K |
0.738 | -0.050 | -3 | 0.752 |
CDK12 |
0.737 | -0.031 | 1 | 0.595 |
PLK4 |
0.737 | -0.089 | 2 | 0.618 |
MST3 |
0.737 | -0.081 | 2 | 0.819 |
AKT1 |
0.736 | -0.004 | -3 | 0.752 |
SNRK |
0.736 | -0.154 | 2 | 0.676 |
WNK4 |
0.736 | -0.138 | -2 | 0.822 |
P38D |
0.736 | 0.015 | 1 | 0.545 |
CAMKK1 |
0.735 | -0.061 | -2 | 0.735 |
MST2 |
0.735 | -0.010 | 1 | 0.780 |
CDK16 |
0.735 | -0.012 | 1 | 0.545 |
HIPK3 |
0.735 | -0.037 | 1 | 0.683 |
DYRK1B |
0.735 | -0.026 | 1 | 0.624 |
PKCT |
0.734 | -0.061 | 2 | 0.735 |
NEK8 |
0.734 | -0.078 | 2 | 0.803 |
BRSK2 |
0.734 | -0.138 | -3 | 0.847 |
CDK14 |
0.734 | -0.036 | 1 | 0.616 |
CDK9 |
0.734 | -0.059 | 1 | 0.628 |
DYRK3 |
0.733 | -0.014 | 1 | 0.684 |
IRAK4 |
0.733 | -0.143 | 1 | 0.755 |
EEF2K |
0.732 | -0.041 | 3 | 0.840 |
DAPK1 |
0.732 | -0.008 | -3 | 0.814 |
CK1E |
0.732 | -0.051 | -3 | 0.520 |
TAO2 |
0.731 | -0.080 | 2 | 0.838 |
TAK1 |
0.731 | -0.012 | 1 | 0.785 |
GCK |
0.731 | -0.042 | 1 | 0.769 |
PHKG2 |
0.731 | -0.092 | -3 | 0.828 |
CAMKK2 |
0.731 | -0.101 | -2 | 0.733 |
SGK1 |
0.730 | 0.012 | -3 | 0.665 |
PDK1 |
0.729 | -0.073 | 1 | 0.753 |
TNIK |
0.729 | -0.024 | 3 | 0.855 |
ERK7 |
0.729 | -0.010 | 2 | 0.541 |
CHK2 |
0.728 | -0.032 | -3 | 0.691 |
JNK1 |
0.728 | -0.005 | 1 | 0.586 |
NEK11 |
0.728 | -0.169 | 1 | 0.748 |
CDK10 |
0.727 | -0.040 | 1 | 0.603 |
PKCE |
0.726 | -0.046 | 2 | 0.717 |
PKCI |
0.726 | -0.085 | 2 | 0.741 |
MINK |
0.726 | -0.074 | 1 | 0.756 |
CK1D |
0.726 | -0.042 | -3 | 0.463 |
MPSK1 |
0.726 | -0.101 | 1 | 0.730 |
BUB1 |
0.725 | -0.044 | -5 | 0.095 |
LKB1 |
0.725 | -0.138 | -3 | 0.826 |
SBK |
0.725 | -0.013 | -3 | 0.630 |
CAMK1A |
0.725 | -0.039 | -3 | 0.708 |
IRAK1 |
0.724 | -0.187 | -1 | 0.718 |
AKT3 |
0.723 | -0.004 | -3 | 0.678 |
HGK |
0.723 | -0.092 | 3 | 0.854 |
MAK |
0.723 | 0.015 | -2 | 0.689 |
NEK4 |
0.723 | -0.145 | 1 | 0.751 |
MRCKB |
0.723 | -0.019 | -3 | 0.779 |
MRCKA |
0.723 | -0.039 | -3 | 0.799 |
ROCK2 |
0.723 | -0.023 | -3 | 0.826 |
TTK |
0.723 | 0.003 | -2 | 0.804 |
PKN1 |
0.722 | -0.062 | -3 | 0.767 |
MEKK6 |
0.722 | -0.138 | 1 | 0.761 |
LRRK2 |
0.722 | -0.142 | 2 | 0.831 |
MST1 |
0.721 | -0.079 | 1 | 0.757 |
CDK6 |
0.721 | -0.018 | 1 | 0.594 |
PAK5 |
0.721 | -0.056 | -2 | 0.617 |
HPK1 |
0.720 | -0.091 | 1 | 0.755 |
ALPHAK3 |
0.720 | 0.083 | -1 | 0.772 |
CK1A2 |
0.720 | -0.055 | -3 | 0.465 |
TTBK1 |
0.719 | -0.155 | 2 | 0.596 |
VRK1 |
0.718 | -0.140 | 2 | 0.808 |
MAP3K15 |
0.718 | -0.147 | 1 | 0.714 |
CDK4 |
0.718 | -0.025 | 1 | 0.580 |
NEK1 |
0.718 | -0.145 | 1 | 0.757 |
KHS1 |
0.718 | -0.061 | 1 | 0.748 |
DMPK1 |
0.718 | -0.012 | -3 | 0.797 |
LOK |
0.718 | -0.102 | -2 | 0.770 |
CK1G1 |
0.718 | -0.076 | -3 | 0.515 |
OSR1 |
0.717 | 0.018 | 2 | 0.795 |
PAK4 |
0.717 | -0.047 | -2 | 0.627 |
KHS2 |
0.717 | -0.046 | 1 | 0.759 |
SLK |
0.717 | -0.064 | -2 | 0.696 |
PDHK3_TYR |
0.716 | 0.100 | 4 | 0.806 |
MOK |
0.716 | -0.018 | 1 | 0.722 |
MEK2 |
0.714 | -0.163 | 2 | 0.808 |
PKG1 |
0.712 | -0.011 | -2 | 0.671 |
PBK |
0.712 | -0.075 | 1 | 0.740 |
CRIK |
0.712 | -0.025 | -3 | 0.750 |
RIPK2 |
0.711 | -0.179 | 1 | 0.692 |
YSK1 |
0.711 | -0.120 | 2 | 0.799 |
ROCK1 |
0.711 | -0.027 | -3 | 0.796 |
MAP2K6_TYR |
0.710 | 0.085 | -1 | 0.861 |
PDHK4_TYR |
0.708 | 0.047 | 2 | 0.863 |
BIKE |
0.708 | -0.039 | 1 | 0.683 |
PDHK1_TYR |
0.708 | 0.089 | -1 | 0.890 |
STK33 |
0.708 | -0.134 | 2 | 0.593 |
MAP2K4_TYR |
0.708 | 0.014 | -1 | 0.859 |
BMPR2_TYR |
0.707 | 0.040 | -1 | 0.865 |
TXK |
0.705 | 0.119 | 1 | 0.860 |
EPHA6 |
0.704 | 0.025 | -1 | 0.873 |
TESK1_TYR |
0.704 | -0.112 | 3 | 0.868 |
HASPIN |
0.704 | -0.052 | -1 | 0.680 |
MYO3B |
0.703 | -0.071 | 2 | 0.814 |
MYO3A |
0.703 | -0.050 | 1 | 0.736 |
NEK3 |
0.703 | -0.166 | 1 | 0.711 |
PINK1_TYR |
0.702 | -0.035 | 1 | 0.802 |
EPHB4 |
0.701 | 0.033 | -1 | 0.842 |
BLK |
0.701 | 0.113 | -1 | 0.858 |
MAP2K7_TYR |
0.700 | -0.152 | 2 | 0.842 |
YES1 |
0.699 | 0.045 | -1 | 0.843 |
PKMYT1_TYR |
0.699 | -0.137 | 3 | 0.842 |
ASK1 |
0.698 | -0.138 | 1 | 0.701 |
ABL2 |
0.698 | 0.054 | -1 | 0.820 |
FER |
0.698 | 0.054 | 1 | 0.878 |
TAO1 |
0.696 | -0.100 | 1 | 0.676 |
INSRR |
0.695 | 0.032 | 3 | 0.757 |
LCK |
0.695 | 0.058 | -1 | 0.845 |
SRMS |
0.695 | 0.054 | 1 | 0.862 |
LIMK2_TYR |
0.695 | -0.101 | -3 | 0.894 |
EPHA4 |
0.695 | 0.036 | 2 | 0.755 |
YANK3 |
0.694 | -0.059 | 2 | 0.376 |
RET |
0.694 | -0.081 | 1 | 0.760 |
FGR |
0.693 | -0.023 | 1 | 0.844 |
CSF1R |
0.693 | -0.017 | 3 | 0.800 |
TYRO3 |
0.693 | -0.061 | 3 | 0.796 |
HCK |
0.692 | 0.014 | -1 | 0.836 |
ROS1 |
0.692 | -0.058 | 3 | 0.773 |
AAK1 |
0.692 | -0.027 | 1 | 0.584 |
ABL1 |
0.691 | 0.011 | -1 | 0.811 |
EPHB2 |
0.691 | 0.039 | -1 | 0.832 |
EPHB1 |
0.691 | 0.016 | 1 | 0.855 |
FYN |
0.691 | 0.085 | -1 | 0.824 |
ITK |
0.691 | 0.013 | -1 | 0.794 |
DDR1 |
0.691 | -0.091 | 4 | 0.728 |
TYK2 |
0.690 | -0.110 | 1 | 0.760 |
EPHB3 |
0.690 | 0.004 | -1 | 0.829 |
STLK3 |
0.690 | -0.103 | 1 | 0.701 |
JAK3 |
0.688 | -0.049 | 1 | 0.740 |
TEC |
0.688 | 0.020 | -1 | 0.744 |
LIMK1_TYR |
0.688 | -0.169 | 2 | 0.838 |
JAK2 |
0.688 | -0.085 | 1 | 0.758 |
MST1R |
0.687 | -0.123 | 3 | 0.807 |
TNK2 |
0.687 | -0.042 | 3 | 0.775 |
CK1A |
0.686 | -0.057 | -3 | 0.370 |
MERTK |
0.685 | 0.008 | 3 | 0.774 |
BMX |
0.685 | 0.006 | -1 | 0.729 |
KIT |
0.684 | -0.042 | 3 | 0.803 |
EPHA7 |
0.684 | 0.004 | 2 | 0.760 |
FGFR2 |
0.683 | -0.054 | 3 | 0.800 |
FLT3 |
0.683 | -0.033 | 3 | 0.796 |
PDGFRB |
0.683 | -0.049 | 3 | 0.809 |
EPHA5 |
0.681 | 0.039 | 2 | 0.749 |
AXL |
0.680 | -0.054 | 3 | 0.779 |
KDR |
0.680 | -0.065 | 3 | 0.774 |
LTK |
0.680 | -0.033 | 3 | 0.750 |
FRK |
0.680 | -0.013 | -1 | 0.867 |
LYN |
0.680 | 0.010 | 3 | 0.725 |
MET |
0.680 | -0.039 | 3 | 0.786 |
PTK2 |
0.679 | 0.057 | -1 | 0.796 |
TEK |
0.679 | -0.096 | 3 | 0.746 |
JAK1 |
0.678 | -0.066 | 1 | 0.699 |
EPHA8 |
0.678 | 0.023 | -1 | 0.825 |
NTRK1 |
0.678 | -0.039 | -1 | 0.803 |
ALK |
0.678 | -0.057 | 3 | 0.731 |
BTK |
0.678 | -0.076 | -1 | 0.755 |
DDR2 |
0.677 | -0.013 | 3 | 0.758 |
EPHA3 |
0.677 | -0.050 | 2 | 0.728 |
FLT1 |
0.677 | -0.040 | -1 | 0.848 |
SRC |
0.676 | 0.022 | -1 | 0.821 |
FGFR1 |
0.676 | -0.092 | 3 | 0.771 |
SYK |
0.676 | 0.062 | -1 | 0.799 |
PTK2B |
0.675 | -0.017 | -1 | 0.779 |
FGFR3 |
0.675 | -0.039 | 3 | 0.778 |
MATK |
0.675 | -0.009 | -1 | 0.754 |
CK1G3 |
0.674 | -0.044 | -3 | 0.320 |
TNK1 |
0.674 | -0.112 | 3 | 0.774 |
PTK6 |
0.674 | -0.066 | -1 | 0.713 |
TNNI3K_TYR |
0.674 | -0.116 | 1 | 0.789 |
NEK10_TYR |
0.674 | -0.096 | 1 | 0.625 |
EPHA1 |
0.673 | -0.086 | 3 | 0.766 |
EGFR |
0.672 | 0.000 | 1 | 0.636 |
NTRK3 |
0.672 | -0.022 | -1 | 0.758 |
INSR |
0.672 | -0.056 | 3 | 0.730 |
ERBB2 |
0.672 | -0.075 | 1 | 0.724 |
CSK |
0.672 | -0.015 | 2 | 0.759 |
NTRK2 |
0.671 | -0.066 | 3 | 0.760 |
FLT4 |
0.670 | -0.081 | 3 | 0.762 |
PDGFRA |
0.670 | -0.170 | 3 | 0.808 |
FGFR4 |
0.668 | 0.012 | -1 | 0.782 |
WEE1_TYR |
0.668 | -0.096 | -1 | 0.724 |
EPHA2 |
0.666 | 0.000 | -1 | 0.791 |
IGF1R |
0.663 | -0.020 | 3 | 0.671 |
CK1G2 |
0.662 | -0.035 | -3 | 0.423 |
ERBB4 |
0.660 | -0.010 | 1 | 0.676 |
YANK2 |
0.659 | -0.082 | 2 | 0.399 |
MUSK |
0.650 | -0.111 | 1 | 0.623 |
FES |
0.647 | -0.061 | -1 | 0.703 |
ZAP70 |
0.642 | -0.024 | -1 | 0.701 |