Motif 574 (n=199)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A075B6Q4 | None | S24 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000256|ARBA:ARBA00043887}. |
| A0A075B6Q4 | None | S35 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000256|ARBA:ARBA00043887}. |
| A6NKT7 | RGPD3 | S1262 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| B5ME19 | EIF3CL | S178 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| L7N2F9 | None | S61 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O00165 | HAX1 | S189 | ochoa | HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}. |
| O00629 | KPNA4 | S72 | ochoa | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Mediates nuclear import of AARS1, MRTFA and RANBP3 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:38512451). {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:28760339, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:38512451}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| O14646 | CHD1 | S1381 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14715 | RGPD8 | S1261 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14795 | UNC13B | S298 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15042 | U2SURP | S747 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O43719 | HTATSF1 | S713 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43815 | STRN | S259 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43815 | STRN | S264 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60293 | ZFC3H1 | S726 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60293 | ZFC3H1 | S729 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60841 | EIF5B | S66 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75128 | COBL | S440 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75152 | ZC3H11A | T177 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75152 | ZC3H11A | T179 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75643 | SNRNP200 | S225 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75717 | WDHD1 | S367 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O95235 | KIF20A | S556 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95391 | SLU7 | S256 | ochoa | Pre-mRNA-splicing factor SLU7 (hSlu7) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| O95400 | CD2BP2 | S68 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| O95622 | ADCY5 | S96 | ochoa | Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}. |
| O95684 | CEP43 | S348 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P00441 | SOD1 | S103 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P01130 | LDLR | S110 | ochoa | Low-density lipoprotein receptor (LDL receptor) | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021). {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:30443021, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.; FUNCTION: (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). {ECO:0000269|PubMed:38182887}.; FUNCTION: (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. {ECO:0000269|PubMed:38245515}. |
| P02545 | LMNA | S568 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P06400 | RB1 | S350 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06733 | ENO1 | S310 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P06748 | NPM1 | S195 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07384 | CAPN1 | S415 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P07900 | HSP90AA1 | S169 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07996 | THBS1 | S938 | ochoa | Thrombospondin-1 (Glycoprotein G) | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:14568985, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:19004835, PubMed:8550562). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:10613822, PubMed:11134179, PubMed:1371676). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:32679764). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:10613822, ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:1371676, ECO:0000269|PubMed:14568985, ECO:0000269|PubMed:15014436, ECO:0000269|PubMed:18285447, ECO:0000269|PubMed:19004835, ECO:0000269|PubMed:2430973, ECO:0000269|PubMed:24511121, ECO:0000269|PubMed:29042481, ECO:0000269|PubMed:32679764, ECO:0000269|PubMed:6489349, ECO:0000269|PubMed:8550562}. |
| P08172 | CHRM2 | S311 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08238 | HSP90AB1 | S164 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10451 | SPP1 | S117 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S120 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S123 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S126 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S129 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11388 | TOP2A | S1351 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P11388 | TOP2A | S1354 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P18583 | SON | S163 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19338 | NCL | S206 | psp | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19838 | NFKB1 | S932 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P20810 | CAST | S577 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20810 | CAST | S660 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23258 | TUBG1 | S131 | psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P23588 | EIF4B | S57 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S192 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S207 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S219 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23763 | VAMP1 | S63 | ochoa | Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1) | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| P24534 | EEF1B2 | S112 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P26232 | CTNNA2 | S651 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P26232 | CTNNA2 | S654 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27540 | ARNT | S68 | ochoa | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| P27694 | RPA1 | S315 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P32314 | FOXN2 | S365 | psp | Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor) | Binds to the purine-rich region in HTLV-I LTR. |
| P32314 | FOXN2 | S369 | psp | Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor) | Binds to the purine-rich region in HTLV-I LTR. |
| P35221 | CTNNA1 | S652 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35221 | CTNNA1 | S655 | ochoa|psp | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P43004 | SLC1A2 | S521 | ochoa | Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}. |
| P43243 | MATR3 | S234 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43243 | MATR3 | S766 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46100 | ATRX | S112 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49792 | RANBP2 | S2237 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52948 | NUP98 | S726 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54132 | BLM | S168 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | S579 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P63027 | VAMP2 | S61 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P78536 | ADAM17 | S785 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| P98175 | RBM10 | S69 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01538 | MYT1 | S108 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q02880 | TOP2B | S1400 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q03001 | DST | S6192 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03135 | CAV1 | S80 | psp | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q03188 | CENPC | S308 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03188 | CENPC | S311 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03188 | CENPC | S713 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04721 | NOTCH2 | S1855 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q06710 | PAX8 | S212 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q08752 | PPID | S201 | ochoa | Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}. |
| Q12872 | SFSWAP | S616 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12872 | SFSWAP | S618 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12906 | ILF3 | S73 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13144 | EIF2B5 | S469 | psp | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13415 | ORC1 | S76 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q14145 | KEAP1 | S599 | psp | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:19489739, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:37339955}. |
| Q14149 | MORC3 | S584 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14157 | UBAP2L | S262 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14568 | HSP90AA2P | S169 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q15047 | SETDB1 | S917 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15047 | SETDB1 | S920 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15424 | SAFB | S761 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15464 | SHB | S258 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15836 | VAMP3 | S44 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q16637 | SMN1 | S49 | psp | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q27J81 | INF2 | S1183 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q27J81 | INF2 | S1188 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q53H47 | SETMAR | S410 | ochoa | Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] | Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17403897, PubMed:17877369, PubMed:18263876, PubMed:20521842, PubMed:22231448, PubMed:24573677). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269|PubMed:16332963, ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897, ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842, ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448, ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}. |
| Q5SSJ5 | HP1BP3 | S442 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T200 | ZC3H13 | S1386 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S1501 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T4S7 | UBR4 | S2743 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T5X7 | BEND3 | S516 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5VZL5 | ZMYM4 | S104 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q5W0B1 | OBI1 | S443 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q5XUX1 | FBXW9 | S22 | ochoa | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q6NT76 | HMBOX1 | S170 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q6NXT6 | TAPT1 | S549 | ochoa | Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) | Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}. |
| Q6P1J9 | CDC73 | S212 | ochoa | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6UB99 | ANKRD11 | S857 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6ZMW3 | EML6 | S1296 | ochoa | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}. |
| Q71H61 | ILDR2 | S595 | ochoa | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) | May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}. |
| Q76FK4 | NOL8 | S378 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7KZ85 | SUPT6H | S91 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7Z3J3 | RGPD4 | S1262 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K6 | MIER3 | S165 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q86U86 | PBRM1 | S178 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86V15 | CASZ1 | T1717 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86V15 | CASZ1 | S1719 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86V15 | CASZ1 | S1722 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q8IUI4 | SNX29P2 | S208 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IUI4 | SNX29P2 | S209 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IWU2 | LMTK2 | S1305 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IXW5 | RPAP2 | S426 | ochoa | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}. |
| Q8IY81 | FTSJ3 | S468 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8IZ21 | PHACTR4 | S533 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N108 | MIER1 | S136 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N157 | AHI1 | S331 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N328 | PGBD3 | S86 | ochoa | PiggyBac transposable element-derived protein 3 | Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}. |
| Q8NC54 | KCT2 | S165 | ochoa | Keratinocyte-associated transmembrane protein 2 | None |
| Q8NEL9 | DDHD1 | S240 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8TD26 | CHD6 | S1360 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TEQ0 | SNX29 | S361 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEQ0 | SNX29 | S362 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEV9 | SMCR8 | S639 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WXE1 | ATRIP | S68 | psp | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q92614 | MYO18A | S403 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92785 | DPF2 | S151 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92797 | SYMPK | S1221 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96GA3 | LTV1 | S200 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96GA3 | LTV1 | S211 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96K49 | TMEM87B | S480 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96KB5 | PBK | S264 | ochoa | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q96MY1 | NOL4L | S179 | ochoa | Nucleolar protein 4-like | None |
| Q96S55 | WRNIP1 | S110 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99613 | EIF3C | S178 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99666 | RGPD5 | S1261 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9GZR1 | SENP6 | S350 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H1E3 | NUCKS1 | S30 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H1E3 | NUCKS1 | S73 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H1E3 | NUCKS1 | S79 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2P0 | ADNP | S886 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H2P0 | ADNP | S970 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H3R0 | KDM4C | S482 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H501 | ESF1 | S485 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H6T3 | RPAP3 | S119 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9HAZ2 | PRDM16 | S1133 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HCD5 | NCOA5 | S96 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCD5 | NCOA5 | S151 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCK1 | ZDBF2 | S111 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NR09 | BIRC6 | S486 | ochoa|psp | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR09 | BIRC6 | S490 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9P2D6 | FAM135A | S636 | ochoa | Protein FAM135A | None |
| Q9P2K3 | RCOR3 | S171 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9UEY8 | ADD3 | S647 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UEY8 | ADD3 | S650 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UH62 | ARMCX3 | S61 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UH62 | ARMCX3 | S67 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UH62 | ARMCX3 | S72 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9ULK5 | VANGL2 | S79 | ochoa | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
| Q9UMZ2 | SYNRG | S469 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UMZ2 | SYNRG | S473 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UMZ2 | SYNRG | S789 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPS6 | SETD1B | T1124 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9Y2K6 | USP20 | S279 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2U8 | LEMD3 | S280 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W1 | THRAP3 | S444 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2W2 | WBP11 | S283 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y3B9 | RRP15 | S67 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y4F1 | FARP1 | S896 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4W2 | LAS1L | S612 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5T5 | USP16 | S423 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y5X1 | SNX9 | S176 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q9Y5X1 | SNX9 | Y177 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q9Y657 | SPIN1 | S196 | ochoa | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| P25205 | MCM3 | S34 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| Q9NPQ8 | RIC8A | S452 | Sugiyama | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| Q8ND56 | LSM14A | S368 | Sugiyama | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| P07384 | CAPN1 | S418 | EPSD|PSP | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| Q7KZ85 | SUPT6H | S73 | Sugiyama | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7KZ85 | SUPT6H | S78 | Sugiyama | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| P10109 | FDX1 | S148 | Sugiyama | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| Q8IW41 | MAPKAPK5 | S386 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 7.453285e-08 | 7.128 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.889399e-07 | 6.539 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.140964e-05 | 4.943 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.782438e-05 | 4.056 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.019770e-04 | 3.695 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.228656e-04 | 3.652 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.833549e-04 | 3.737 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.189163e-04 | 3.925 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.228656e-04 | 3.652 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.019770e-04 | 3.695 |
| R-HSA-68886 | M Phase | 2.364164e-04 | 3.626 |
| R-HSA-68875 | Mitotic Prophase | 1.694174e-04 | 3.771 |
| R-HSA-9700645 | ALK mutants bind TKIs | 3.761117e-04 | 3.425 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.643420e-04 | 3.438 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 8.215474e-04 | 3.085 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.086873e-04 | 3.042 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.086873e-04 | 3.042 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.102148e-03 | 2.958 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.102148e-03 | 2.958 |
| R-HSA-191859 | snRNP Assembly | 1.093831e-03 | 2.961 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.093831e-03 | 2.961 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.102148e-03 | 2.958 |
| R-HSA-3371556 | Cellular response to heat stress | 9.811998e-04 | 3.008 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.208956e-03 | 2.918 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.208956e-03 | 2.918 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.443942e-03 | 2.840 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.709035e-03 | 2.767 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.853472e-03 | 2.732 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.167321e-03 | 2.664 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.416968e-03 | 2.617 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.337205e-03 | 2.631 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.337205e-03 | 2.631 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.917767e-03 | 2.535 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.761027e-03 | 2.559 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 2.986522e-03 | 2.525 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.325492e-03 | 2.478 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.552514e-03 | 2.449 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.782733e-03 | 2.422 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.778387e-03 | 2.423 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.871838e-03 | 2.412 |
| R-HSA-8953854 | Metabolism of RNA | 4.272425e-03 | 2.369 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 4.863990e-03 | 2.313 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 4.863990e-03 | 2.313 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.845383e-03 | 2.315 |
| R-HSA-8863678 | Neurodegenerative Diseases | 5.061966e-03 | 2.296 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 5.061966e-03 | 2.296 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.138606e-03 | 2.289 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 5.960478e-03 | 2.225 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 5.960478e-03 | 2.225 |
| R-HSA-69481 | G2/M Checkpoints | 6.016730e-03 | 2.221 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 6.042861e-03 | 2.219 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 6.572886e-03 | 2.182 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 7.713786e-03 | 2.113 |
| R-HSA-68962 | Activation of the pre-replicative complex | 8.325275e-03 | 2.080 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 8.456666e-03 | 2.073 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.310982e-03 | 2.080 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 8.456666e-03 | 2.073 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.899871e-03 | 2.102 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.727288e-03 | 2.059 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 9.851575e-03 | 2.006 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 9.851575e-03 | 2.006 |
| R-HSA-69275 | G2/M Transition | 9.486757e-03 | 2.023 |
| R-HSA-8939211 | ESR-mediated signaling | 9.652524e-03 | 2.015 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.859769e-03 | 2.006 |
| R-HSA-70171 | Glycolysis | 9.180634e-03 | 2.037 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.966669e-03 | 2.001 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.032713e-02 | 1.986 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.043861e-02 | 1.981 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.130036e-02 | 1.947 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.180350e-02 | 1.928 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.210281e-02 | 1.917 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.180350e-02 | 1.928 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.210281e-02 | 1.917 |
| R-HSA-68877 | Mitotic Prometaphase | 1.124380e-02 | 1.949 |
| R-HSA-211000 | Gene Silencing by RNA | 1.210281e-02 | 1.917 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.258482e-02 | 1.900 |
| R-HSA-3371511 | HSF1 activation | 1.339511e-02 | 1.873 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.365337e-02 | 1.865 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.422549e-02 | 1.847 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.510317e-02 | 1.821 |
| R-HSA-380287 | Centrosome maturation | 1.541483e-02 | 1.812 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.788562e-02 | 1.747 |
| R-HSA-70326 | Glucose metabolism | 1.757862e-02 | 1.755 |
| R-HSA-74160 | Gene expression (Transcription) | 1.662876e-02 | 1.779 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.865657e-02 | 1.729 |
| R-HSA-73886 | Chromosome Maintenance | 1.971635e-02 | 1.705 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.971635e-02 | 1.705 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.013178e-02 | 1.696 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.247371e-02 | 1.648 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.247371e-02 | 1.648 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.247371e-02 | 1.648 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.247371e-02 | 1.648 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.247371e-02 | 1.648 |
| R-HSA-69206 | G1/S Transition | 2.261965e-02 | 1.646 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.142705e-02 | 1.669 |
| R-HSA-9675135 | Diseases of DNA repair | 2.425030e-02 | 1.615 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.385854e-02 | 1.622 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.484858e-02 | 1.605 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.549049e-02 | 1.594 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.613420e-02 | 1.583 |
| R-HSA-168255 | Influenza Infection | 2.651453e-02 | 1.577 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.718818e-02 | 1.566 |
| R-HSA-2262752 | Cellular responses to stress | 2.810747e-02 | 1.551 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.864581e-02 | 1.543 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.864581e-02 | 1.543 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.864581e-02 | 1.543 |
| R-HSA-72187 | mRNA 3'-end processing | 3.168255e-02 | 1.499 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.096300e-02 | 1.509 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.352148e-02 | 1.475 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.581019e-02 | 1.446 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.352148e-02 | 1.475 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.096300e-02 | 1.509 |
| R-HSA-4839726 | Chromatin organization | 3.514927e-02 | 1.454 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.335176e-02 | 1.477 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.142184e-02 | 1.503 |
| R-HSA-9679506 | SARS-CoV Infections | 3.269594e-02 | 1.486 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.587290e-02 | 1.445 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.777401e-02 | 1.423 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.833643e-02 | 1.416 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.444506e-02 | 1.352 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.444506e-02 | 1.352 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.444506e-02 | 1.352 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.444506e-02 | 1.352 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.444506e-02 | 1.352 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.444506e-02 | 1.352 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.444506e-02 | 1.352 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.444506e-02 | 1.352 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.803183e-02 | 1.318 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.803183e-02 | 1.318 |
| R-HSA-72172 | mRNA Splicing | 4.393896e-02 | 1.357 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.480253e-02 | 1.349 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.092865e-02 | 1.388 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.908341e-02 | 1.309 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.908341e-02 | 1.309 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.630389e-02 | 1.334 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.317597e-02 | 1.365 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.868311e-02 | 1.313 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 4.092865e-02 | 1.388 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.486074e-02 | 1.348 |
| R-HSA-9830364 | Formation of the nephric duct | 4.908341e-02 | 1.309 |
| R-HSA-525793 | Myogenesis | 5.192191e-02 | 1.285 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.308401e-02 | 1.275 |
| R-HSA-68882 | Mitotic Anaphase | 5.394201e-02 | 1.268 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.406446e-02 | 1.267 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 5.481773e-02 | 1.261 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 5.481773e-02 | 1.261 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.482284e-02 | 1.261 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.483314e-02 | 1.261 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.524584e-02 | 1.258 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.658872e-02 | 1.247 |
| R-HSA-622312 | Inflammasomes | 5.776923e-02 | 1.238 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.069915e-02 | 1.217 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 6.077479e-02 | 1.216 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 6.592520e-02 | 1.181 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 6.592520e-02 | 1.181 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.692507e-02 | 1.061 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.692507e-02 | 1.061 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.724824e-02 | 1.012 |
| R-HSA-8964026 | Chylomicron clearance | 9.724824e-02 | 1.012 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 9.724824e-02 | 1.012 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 9.724824e-02 | 1.012 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.074553e-01 | 0.969 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.074553e-01 | 0.969 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.074553e-01 | 0.969 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.663319e-01 | 0.779 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.663319e-01 | 0.779 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.663319e-01 | 0.779 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.757619e-01 | 0.755 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.757619e-01 | 0.755 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.757619e-01 | 0.755 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 7.010013e-02 | 1.154 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.943050e-01 | 0.712 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.034203e-01 | 0.692 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.034203e-01 | 0.692 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.124331e-01 | 0.673 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.124331e-01 | 0.673 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.213444e-01 | 0.655 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.213444e-01 | 0.655 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.301555e-01 | 0.638 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.388674e-01 | 0.622 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.388674e-01 | 0.622 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.474812e-01 | 0.606 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.474812e-01 | 0.606 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.474812e-01 | 0.606 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.474812e-01 | 0.606 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.474812e-01 | 0.606 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.474812e-01 | 0.606 |
| R-HSA-774815 | Nucleosome assembly | 1.224458e-01 | 0.912 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.224458e-01 | 0.912 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.493192e-01 | 0.826 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.493192e-01 | 0.826 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.532508e-01 | 0.815 |
| R-HSA-72649 | Translation initiation complex formation | 1.572025e-01 | 0.804 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.273726e-02 | 1.033 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.273726e-02 | 1.033 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.651627e-01 | 0.782 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.572363e-01 | 0.803 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.141435e-01 | 0.669 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.850859e-01 | 0.733 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.567945e-01 | 0.805 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.943050e-01 | 0.712 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.850859e-01 | 0.733 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.213444e-01 | 0.655 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.388674e-01 | 0.622 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.532508e-01 | 0.815 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.695193e-01 | 0.771 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.471486e-01 | 0.832 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.567945e-01 | 0.805 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.207574e-02 | 1.207 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.599481e-01 | 0.796 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.207574e-02 | 1.207 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.737156e-01 | 0.760 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.040838e-01 | 0.983 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.335243e-01 | 0.874 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 9.346913e-02 | 1.029 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.190432e-02 | 1.087 |
| R-HSA-203615 | eNOS activation | 7.985671e-02 | 1.098 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.307826e-01 | 0.637 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 8.692507e-02 | 1.061 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.724824e-02 | 1.012 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 1.074553e-01 | 0.969 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.175476e-01 | 0.930 |
| R-HSA-176974 | Unwinding of DNA | 1.275265e-01 | 0.894 |
| R-HSA-192905 | vRNP Assembly | 1.471486e-01 | 0.832 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.567945e-01 | 0.805 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.663319e-01 | 0.779 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.757619e-01 | 0.755 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.943050e-01 | 0.712 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.301555e-01 | 0.638 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.113340e-01 | 0.953 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.493192e-01 | 0.826 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.532508e-01 | 0.815 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.731923e-01 | 0.761 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.349566e-01 | 0.629 |
| R-HSA-5693538 | Homology Directed Repair | 1.906572e-01 | 0.720 |
| R-HSA-9843745 | Adipogenesis | 8.794176e-02 | 1.056 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.943050e-01 | 0.712 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.266136e-01 | 0.645 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.041278e-01 | 0.982 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 7.648449e-02 | 1.116 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.373930e-01 | 0.862 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.850859e-01 | 0.733 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.943050e-01 | 0.712 |
| R-HSA-912446 | Meiotic recombination | 1.454087e-01 | 0.837 |
| R-HSA-196108 | Pregnenolone biosynthesis | 2.474812e-01 | 0.606 |
| R-HSA-69239 | Synthesis of DNA | 1.545392e-01 | 0.811 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.391350e-01 | 0.621 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.338138e-01 | 0.873 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.175476e-01 | 0.930 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.175476e-01 | 0.930 |
| R-HSA-69190 | DNA strand elongation | 7.010013e-02 | 1.154 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 2.474812e-01 | 0.606 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.833521e-02 | 1.054 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.105218e-01 | 0.677 |
| R-HSA-194138 | Signaling by VEGF | 7.673610e-02 | 1.115 |
| R-HSA-1500620 | Meiosis | 9.052494e-02 | 1.043 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.992817e-01 | 0.701 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.651627e-01 | 0.782 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 9.724824e-02 | 1.012 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.275265e-01 | 0.894 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.005096e-01 | 0.998 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.005096e-01 | 0.998 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.076923e-01 | 0.968 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.360937e-01 | 0.866 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 7.330638e-02 | 1.135 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.709352e-01 | 0.767 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 7.330638e-02 | 1.135 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.301555e-01 | 0.638 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.680508e-02 | 1.061 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 8.692507e-02 | 1.061 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.567945e-01 | 0.805 |
| R-HSA-9857492 | Protein lipoylation | 1.943050e-01 | 0.712 |
| R-HSA-163615 | PKA activation | 2.301555e-01 | 0.638 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.454087e-01 | 0.837 |
| R-HSA-9609690 | HCMV Early Events | 1.000273e-01 | 1.000 |
| R-HSA-157579 | Telomere Maintenance | 1.259212e-01 | 0.900 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.213444e-01 | 0.655 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.076923e-01 | 0.968 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 2.266136e-01 | 0.645 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.262082e-01 | 0.899 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.262082e-01 | 0.899 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 6.592520e-02 | 1.181 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 7.648449e-02 | 1.116 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 8.692507e-02 | 1.061 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.692507e-02 | 1.061 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.692507e-02 | 1.061 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.692507e-02 | 1.061 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 1.175476e-01 | 0.930 |
| R-HSA-448706 | Interleukin-1 processing | 1.275265e-01 | 0.894 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.943050e-01 | 0.712 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 8.319792e-02 | 1.080 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.213444e-01 | 0.655 |
| R-HSA-3371568 | Attenuation phase | 1.005096e-01 | 0.998 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.599481e-01 | 0.796 |
| R-HSA-69242 | S Phase | 1.220129e-01 | 0.914 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.301555e-01 | 0.638 |
| R-HSA-5358508 | Mismatch Repair | 2.301555e-01 | 0.638 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.663319e-01 | 0.779 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.663319e-01 | 0.779 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.850859e-01 | 0.733 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.773993e-02 | 1.169 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.120345e-01 | 0.951 |
| R-HSA-9609646 | HCMV Infection | 1.949907e-01 | 0.710 |
| R-HSA-5617833 | Cilium Assembly | 2.152450e-01 | 0.667 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.807377e-02 | 1.008 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.943050e-01 | 0.712 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.373930e-01 | 0.862 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.943050e-01 | 0.712 |
| R-HSA-180786 | Extension of Telomeres | 1.772309e-01 | 0.751 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.266136e-01 | 0.645 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.134818e-02 | 1.147 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.224458e-01 | 0.912 |
| R-HSA-1474165 | Reproduction | 2.316360e-01 | 0.635 |
| R-HSA-211976 | Endogenous sterols | 1.853515e-01 | 0.732 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.976283e-01 | 0.704 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.950693e-02 | 1.002 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.253170e-02 | 1.139 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 7.655906e-02 | 1.116 |
| R-HSA-9610379 | HCMV Late Events | 1.398582e-01 | 0.854 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.391350e-01 | 0.621 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.894318e-01 | 0.723 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.388674e-01 | 0.622 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.306778e-01 | 0.637 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 7.330638e-02 | 1.135 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.064697e-01 | 0.973 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.184821e-01 | 0.926 |
| R-HSA-1538133 | G0 and Early G1 | 7.010013e-02 | 1.154 |
| R-HSA-69205 | G1/S-Specific Transcription | 8.658131e-02 | 1.063 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.301555e-01 | 0.638 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.737156e-01 | 0.760 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.518570e-01 | 0.819 |
| R-HSA-449836 | Other interleukin signaling | 2.388674e-01 | 0.622 |
| R-HSA-162906 | HIV Infection | 1.519663e-01 | 0.818 |
| R-HSA-373755 | Semaphorin interactions | 1.935243e-01 | 0.713 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.757619e-01 | 0.755 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.213444e-01 | 0.655 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.497188e-02 | 1.022 |
| R-HSA-9830369 | Kidney development | 2.100013e-01 | 0.678 |
| R-HSA-913531 | Interferon Signaling | 1.784275e-01 | 0.749 |
| R-HSA-1474244 | Extracellular matrix organization | 2.113823e-01 | 0.675 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.850859e-01 | 0.733 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.960410e-02 | 1.048 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.088322e-01 | 0.963 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.388674e-01 | 0.622 |
| R-HSA-186797 | Signaling by PDGF | 1.894318e-01 | 0.723 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.017429e-01 | 0.695 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.107029e-01 | 0.956 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.806140e-01 | 0.743 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.460280e-01 | 0.836 |
| R-HSA-72306 | tRNA processing | 1.695193e-01 | 0.771 |
| R-HSA-162587 | HIV Life Cycle | 1.398582e-01 | 0.854 |
| R-HSA-5619102 | SLC transporter disorders | 1.608253e-01 | 0.794 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 9.697092e-02 | 1.013 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.475024e-01 | 0.606 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.475024e-01 | 0.606 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.557366e-01 | 0.592 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.558800e-01 | 0.592 |
| R-HSA-216083 | Integrin cell surface interactions | 2.558800e-01 | 0.592 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.559981e-01 | 0.592 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.559981e-01 | 0.592 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.559981e-01 | 0.592 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.559981e-01 | 0.592 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.559981e-01 | 0.592 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.559981e-01 | 0.592 |
| R-HSA-210991 | Basigin interactions | 2.559981e-01 | 0.592 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.587751e-01 | 0.587 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.618185e-01 | 0.582 |
| R-HSA-9833482 | PKR-mediated signaling | 2.642631e-01 | 0.578 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.642631e-01 | 0.578 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.644191e-01 | 0.578 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.644191e-01 | 0.578 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.727453e-01 | 0.564 |
| R-HSA-8964038 | LDL clearance | 2.727453e-01 | 0.564 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.727453e-01 | 0.564 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.727453e-01 | 0.564 |
| R-HSA-3000170 | Syndecan interactions | 2.809778e-01 | 0.551 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.809778e-01 | 0.551 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.852162e-01 | 0.545 |
| R-HSA-429947 | Deadenylation of mRNA | 2.891176e-01 | 0.539 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.891176e-01 | 0.539 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.891176e-01 | 0.539 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.891176e-01 | 0.539 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.891176e-01 | 0.539 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.891176e-01 | 0.539 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.971657e-01 | 0.527 |
| R-HSA-3214842 | HDMs demethylate histones | 2.971657e-01 | 0.527 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.971657e-01 | 0.527 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.977643e-01 | 0.526 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.986350e-01 | 0.525 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.051232e-01 | 0.516 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.051232e-01 | 0.516 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.051232e-01 | 0.516 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.051232e-01 | 0.516 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.051232e-01 | 0.516 |
| R-HSA-70635 | Urea cycle | 3.051232e-01 | 0.516 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.051232e-01 | 0.516 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.051232e-01 | 0.516 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.067341e-01 | 0.513 |
| R-HSA-69306 | DNA Replication | 3.078967e-01 | 0.512 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.078967e-01 | 0.512 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.109867e-01 | 0.507 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.129911e-01 | 0.504 |
| R-HSA-264876 | Insulin processing | 3.129911e-01 | 0.504 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.207704e-01 | 0.494 |
| R-HSA-72312 | rRNA processing | 3.220433e-01 | 0.492 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.268931e-01 | 0.486 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.284621e-01 | 0.484 |
| R-HSA-209968 | Thyroxine biosynthesis | 3.284621e-01 | 0.484 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.284621e-01 | 0.484 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.360672e-01 | 0.474 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.360672e-01 | 0.474 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.360672e-01 | 0.474 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.360672e-01 | 0.474 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.360672e-01 | 0.474 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.419085e-01 | 0.466 |
| R-HSA-157118 | Signaling by NOTCH | 3.425388e-01 | 0.465 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.434010e-01 | 0.464 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.435866e-01 | 0.464 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.475087e-01 | 0.459 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.510213e-01 | 0.455 |
| R-HSA-422356 | Regulation of insulin secretion | 3.516079e-01 | 0.454 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.556983e-01 | 0.449 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.556983e-01 | 0.449 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 3.583722e-01 | 0.446 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.583722e-01 | 0.446 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.583722e-01 | 0.446 |
| R-HSA-9930044 | Nuclear RNA decay | 3.583722e-01 | 0.446 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.583722e-01 | 0.446 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.583722e-01 | 0.446 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.605069e-01 | 0.443 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.638599e-01 | 0.439 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.656403e-01 | 0.437 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.656403e-01 | 0.437 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.656403e-01 | 0.437 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.656403e-01 | 0.437 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.679137e-01 | 0.434 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.727343e-01 | 0.429 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.728266e-01 | 0.428 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.728266e-01 | 0.428 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.728266e-01 | 0.428 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.728266e-01 | 0.428 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.760078e-01 | 0.425 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.799319e-01 | 0.420 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.799319e-01 | 0.420 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.869571e-01 | 0.412 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.869571e-01 | 0.412 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.869571e-01 | 0.412 |
| R-HSA-163560 | Triglyceride catabolism | 3.869571e-01 | 0.412 |
| R-HSA-111933 | Calmodulin induced events | 3.869571e-01 | 0.412 |
| R-HSA-111997 | CaM pathway | 3.869571e-01 | 0.412 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 3.939031e-01 | 0.405 |
| R-HSA-2559583 | Cellular Senescence | 3.941594e-01 | 0.404 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.960527e-01 | 0.402 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.007709e-01 | 0.397 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.075613e-01 | 0.390 |
| R-HSA-1643685 | Disease | 4.105047e-01 | 0.387 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.142751e-01 | 0.383 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.142751e-01 | 0.383 |
| R-HSA-5260271 | Diseases of Immune System | 4.142751e-01 | 0.383 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.142751e-01 | 0.383 |
| R-HSA-9646399 | Aggrephagy | 4.142751e-01 | 0.383 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.142751e-01 | 0.383 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.209133e-01 | 0.376 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.209133e-01 | 0.376 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.209133e-01 | 0.376 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.209133e-01 | 0.376 |
| R-HSA-9824446 | Viral Infection Pathways | 4.321833e-01 | 0.364 |
| R-HSA-991365 | Activation of GABAB receptors | 4.339660e-01 | 0.363 |
| R-HSA-977444 | GABA B receptor activation | 4.339660e-01 | 0.363 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.339660e-01 | 0.363 |
| R-HSA-111996 | Ca-dependent events | 4.339660e-01 | 0.363 |
| R-HSA-165159 | MTOR signalling | 4.339660e-01 | 0.363 |
| R-HSA-446728 | Cell junction organization | 4.394938e-01 | 0.357 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.403822e-01 | 0.356 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.423426e-01 | 0.354 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.467260e-01 | 0.350 |
| R-HSA-69236 | G1 Phase | 4.467260e-01 | 0.350 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.467260e-01 | 0.350 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.467260e-01 | 0.350 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.467260e-01 | 0.350 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.470191e-01 | 0.350 |
| R-HSA-9658195 | Leishmania infection | 4.470191e-01 | 0.350 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.529984e-01 | 0.344 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.529984e-01 | 0.344 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.529984e-01 | 0.344 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.529984e-01 | 0.344 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.529984e-01 | 0.344 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.592000e-01 | 0.338 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.592000e-01 | 0.338 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.592000e-01 | 0.338 |
| R-HSA-75153 | Apoptotic execution phase | 4.592000e-01 | 0.338 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.618204e-01 | 0.336 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.653317e-01 | 0.332 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.653317e-01 | 0.332 |
| R-HSA-9634597 | GPER1 signaling | 4.713942e-01 | 0.327 |
| R-HSA-70263 | Gluconeogenesis | 4.713942e-01 | 0.327 |
| R-HSA-73893 | DNA Damage Bypass | 4.773884e-01 | 0.321 |
| R-HSA-9766229 | Degradation of CDH1 | 4.773884e-01 | 0.321 |
| R-HSA-114608 | Platelet degranulation | 4.803684e-01 | 0.318 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.891746e-01 | 0.311 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.891746e-01 | 0.311 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.949683e-01 | 0.305 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.949683e-01 | 0.305 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.949683e-01 | 0.305 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.006965e-01 | 0.300 |
| R-HSA-1221632 | Meiotic synapsis | 5.006965e-01 | 0.300 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.015799e-01 | 0.300 |
| R-HSA-162582 | Signal Transduction | 5.034520e-01 | 0.298 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.056703e-01 | 0.296 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.063602e-01 | 0.296 |
| R-HSA-418990 | Adherens junctions interactions | 5.088132e-01 | 0.293 |
| R-HSA-418597 | G alpha (z) signalling events | 5.119599e-01 | 0.291 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.174965e-01 | 0.286 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 5.174965e-01 | 0.286 |
| R-HSA-177929 | Signaling by EGFR | 5.174965e-01 | 0.286 |
| R-HSA-75893 | TNF signaling | 5.174965e-01 | 0.286 |
| R-HSA-163685 | Integration of energy metabolism | 5.197681e-01 | 0.284 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.229706e-01 | 0.282 |
| R-HSA-1483166 | Synthesis of PA | 5.229706e-01 | 0.282 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.229706e-01 | 0.282 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.283829e-01 | 0.277 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.283829e-01 | 0.277 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.283829e-01 | 0.277 |
| R-HSA-1500931 | Cell-Cell communication | 5.320356e-01 | 0.274 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.337342e-01 | 0.273 |
| R-HSA-8979227 | Triglyceride metabolism | 5.337342e-01 | 0.273 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.337342e-01 | 0.273 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.370120e-01 | 0.270 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.390250e-01 | 0.268 |
| R-HSA-977443 | GABA receptor activation | 5.390250e-01 | 0.268 |
| R-HSA-983189 | Kinesins | 5.390250e-01 | 0.268 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.390250e-01 | 0.268 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.390250e-01 | 0.268 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.390250e-01 | 0.268 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.390250e-01 | 0.268 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.390250e-01 | 0.268 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.390250e-01 | 0.268 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.413554e-01 | 0.267 |
| R-HSA-450294 | MAP kinase activation | 5.442562e-01 | 0.264 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.442562e-01 | 0.264 |
| R-HSA-112043 | PLC beta mediated events | 5.442562e-01 | 0.264 |
| R-HSA-1442490 | Collagen degradation | 5.442562e-01 | 0.264 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.482838e-01 | 0.261 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.494283e-01 | 0.260 |
| R-HSA-211981 | Xenobiotics | 5.595980e-01 | 0.252 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.645969e-01 | 0.248 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.645969e-01 | 0.248 |
| R-HSA-9758941 | Gastrulation | 5.669697e-01 | 0.246 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.695394e-01 | 0.244 |
| R-HSA-112040 | G-protein mediated events | 5.744261e-01 | 0.241 |
| R-HSA-196071 | Metabolism of steroid hormones | 5.744261e-01 | 0.241 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.744261e-01 | 0.241 |
| R-HSA-5663205 | Infectious disease | 5.788160e-01 | 0.237 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.792576e-01 | 0.237 |
| R-HSA-5218859 | Regulated Necrosis | 5.792576e-01 | 0.237 |
| R-HSA-72766 | Translation | 5.819781e-01 | 0.235 |
| R-HSA-73887 | Death Receptor Signaling | 5.830037e-01 | 0.234 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.838684e-01 | 0.234 |
| R-HSA-1989781 | PPARA activates gene expression | 5.861579e-01 | 0.232 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.887576e-01 | 0.230 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.887576e-01 | 0.230 |
| R-HSA-448424 | Interleukin-17 signaling | 5.887576e-01 | 0.230 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.887576e-01 | 0.230 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.887576e-01 | 0.230 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.887576e-01 | 0.230 |
| R-HSA-9612973 | Autophagy | 5.892946e-01 | 0.230 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.924136e-01 | 0.227 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.934273e-01 | 0.227 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.934273e-01 | 0.227 |
| R-HSA-8978934 | Metabolism of cofactors | 5.934273e-01 | 0.227 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.934273e-01 | 0.227 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.934273e-01 | 0.227 |
| R-HSA-421270 | Cell-cell junction organization | 5.964334e-01 | 0.224 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.980442e-01 | 0.223 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.026090e-01 | 0.220 |
| R-HSA-5688426 | Deubiquitination | 6.063457e-01 | 0.217 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.071223e-01 | 0.217 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.071223e-01 | 0.217 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.115845e-01 | 0.214 |
| R-HSA-8852135 | Protein ubiquitination | 6.115845e-01 | 0.214 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.115845e-01 | 0.214 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.159964e-01 | 0.210 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 6.226383e-01 | 0.206 |
| R-HSA-212436 | Generic Transcription Pathway | 6.226635e-01 | 0.206 |
| R-HSA-4086400 | PCP/CE pathway | 6.246711e-01 | 0.204 |
| R-HSA-9659379 | Sensory processing of sound | 6.289351e-01 | 0.201 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 6.289351e-01 | 0.201 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.315762e-01 | 0.200 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.331509e-01 | 0.198 |
| R-HSA-6798695 | Neutrophil degranulation | 6.352422e-01 | 0.197 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.373191e-01 | 0.196 |
| R-HSA-597592 | Post-translational protein modification | 6.395254e-01 | 0.194 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.414401e-01 | 0.193 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.427537e-01 | 0.192 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.427537e-01 | 0.192 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.427537e-01 | 0.192 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.427537e-01 | 0.192 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.455578e-01 | 0.190 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.495431e-01 | 0.187 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.496837e-01 | 0.187 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.535260e-01 | 0.185 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 6.601751e-01 | 0.180 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.613573e-01 | 0.180 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.652067e-01 | 0.177 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.689784e-01 | 0.175 |
| R-HSA-9663891 | Selective autophagy | 6.690125e-01 | 0.175 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.700188e-01 | 0.174 |
| R-HSA-3781865 | Diseases of glycosylation | 6.726512e-01 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.727753e-01 | 0.172 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.761633e-01 | 0.170 |
| R-HSA-202424 | Downstream TCR signaling | 6.764956e-01 | 0.170 |
| R-HSA-73884 | Base Excision Repair | 6.764956e-01 | 0.170 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.874059e-01 | 0.163 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.874059e-01 | 0.163 |
| R-HSA-391251 | Protein folding | 6.874059e-01 | 0.163 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.931045e-01 | 0.159 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.944753e-01 | 0.158 |
| R-HSA-1474290 | Collagen formation | 6.944753e-01 | 0.158 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.013857e-01 | 0.154 |
| R-HSA-195721 | Signaling by WNT | 7.025305e-01 | 0.153 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.047824e-01 | 0.152 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.047824e-01 | 0.152 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.114609e-01 | 0.148 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.114609e-01 | 0.148 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.114609e-01 | 0.148 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.114609e-01 | 0.148 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.124984e-01 | 0.147 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.179891e-01 | 0.144 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.211980e-01 | 0.142 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.243705e-01 | 0.140 |
| R-HSA-5357801 | Programmed Cell Death | 7.263657e-01 | 0.139 |
| R-HSA-111885 | Opioid Signalling | 7.306082e-01 | 0.136 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.367054e-01 | 0.133 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.367054e-01 | 0.133 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.455950e-01 | 0.127 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.455950e-01 | 0.127 |
| R-HSA-449147 | Signaling by Interleukins | 7.462707e-01 | 0.127 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.484913e-01 | 0.126 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.513548e-01 | 0.124 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.513548e-01 | 0.124 |
| R-HSA-202403 | TCR signaling | 7.513548e-01 | 0.124 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.597523e-01 | 0.119 |
| R-HSA-8951664 | Neddylation | 7.606129e-01 | 0.119 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.651934e-01 | 0.116 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.678677e-01 | 0.115 |
| R-HSA-199991 | Membrane Trafficking | 7.754317e-01 | 0.110 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.757104e-01 | 0.110 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.782657e-01 | 0.109 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.807919e-01 | 0.107 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.807919e-01 | 0.107 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.807919e-01 | 0.107 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.857589e-01 | 0.105 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.882003e-01 | 0.103 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.882003e-01 | 0.103 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.906139e-01 | 0.102 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.906139e-01 | 0.102 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.930003e-01 | 0.101 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.976921e-01 | 0.098 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.976921e-01 | 0.098 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.976921e-01 | 0.098 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.999982e-01 | 0.097 |
| R-HSA-392499 | Metabolism of proteins | 8.004942e-01 | 0.097 |
| R-HSA-73894 | DNA Repair | 8.083753e-01 | 0.092 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.089640e-01 | 0.092 |
| R-HSA-112316 | Neuronal System | 8.090317e-01 | 0.092 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.154250e-01 | 0.089 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.257139e-01 | 0.083 |
| R-HSA-5173105 | O-linked glycosylation | 8.277022e-01 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 8.354323e-01 | 0.078 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.359927e-01 | 0.078 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.428173e-01 | 0.074 |
| R-HSA-2187338 | Visual phototransduction | 8.481389e-01 | 0.072 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.488753e-01 | 0.071 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.498727e-01 | 0.071 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.532814e-01 | 0.069 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.532814e-01 | 0.069 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.566130e-01 | 0.067 |
| R-HSA-9609507 | Protein localization | 8.582506e-01 | 0.066 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.661633e-01 | 0.062 |
| R-HSA-109581 | Apoptosis | 8.721759e-01 | 0.059 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.860579e-01 | 0.053 |
| R-HSA-418555 | G alpha (s) signalling events | 8.860579e-01 | 0.053 |
| R-HSA-5668914 | Diseases of metabolism | 8.862716e-01 | 0.052 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.873607e-01 | 0.052 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.911811e-01 | 0.050 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.094823e-01 | 0.041 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.183954e-01 | 0.037 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.187761e-01 | 0.037 |
| R-HSA-428157 | Sphingolipid metabolism | 9.193302e-01 | 0.037 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.211680e-01 | 0.036 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.211680e-01 | 0.036 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.224884e-01 | 0.035 |
| R-HSA-6805567 | Keratinization | 9.247195e-01 | 0.034 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.297507e-01 | 0.032 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.305560e-01 | 0.031 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.339543e-01 | 0.030 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.473555e-01 | 0.023 |
| R-HSA-211859 | Biological oxidations | 9.484699e-01 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 9.566535e-01 | 0.019 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.577330e-01 | 0.019 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.730896e-01 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 9.730896e-01 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 9.807779e-01 | 0.008 |
| R-HSA-1266738 | Developmental Biology | 9.825040e-01 | 0.008 |
| R-HSA-109582 | Hemostasis | 9.829395e-01 | 0.007 |
| R-HSA-1280218 | Adaptive Immune System | 9.839290e-01 | 0.007 |
| R-HSA-422475 | Axon guidance | 9.890138e-01 | 0.005 |
| R-HSA-168256 | Immune System | 9.891082e-01 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.915875e-01 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.918768e-01 | 0.004 |
| R-HSA-9675108 | Nervous system development | 9.924790e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.948177e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.970224e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.990058e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.991472e-01 | 0.000 |
| R-HSA-168249 | Innate Immune System | 9.995496e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.995957e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.996125e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999943e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.303 | 2 | 0.859 |
CLK3 |
0.863 | 0.240 | 1 | 0.808 |
MOS |
0.859 | 0.306 | 1 | 0.914 |
CDC7 |
0.859 | 0.209 | 1 | 0.894 |
DSTYK |
0.855 | 0.245 | 2 | 0.884 |
BMPR1B |
0.854 | 0.356 | 1 | 0.818 |
FAM20C |
0.854 | 0.244 | 2 | 0.662 |
CAMK2G |
0.852 | 0.189 | 2 | 0.846 |
GRK1 |
0.852 | 0.230 | -2 | 0.744 |
GRK6 |
0.851 | 0.259 | 1 | 0.851 |
GCN2 |
0.848 | 0.065 | 2 | 0.814 |
GRK7 |
0.848 | 0.273 | 1 | 0.780 |
PIM3 |
0.847 | 0.083 | -3 | 0.780 |
NEK6 |
0.846 | 0.176 | -2 | 0.906 |
BMPR1A |
0.845 | 0.366 | 1 | 0.821 |
IKKB |
0.845 | 0.041 | -2 | 0.705 |
ACVR2B |
0.844 | 0.344 | -2 | 0.902 |
GRK4 |
0.844 | 0.189 | -2 | 0.828 |
NDR2 |
0.844 | 0.053 | -3 | 0.774 |
PRPK |
0.843 | -0.067 | -1 | 0.758 |
GRK5 |
0.843 | 0.100 | -3 | 0.833 |
ALK2 |
0.843 | 0.335 | -2 | 0.879 |
RAF1 |
0.842 | 0.018 | 1 | 0.843 |
IKKA |
0.842 | 0.148 | -2 | 0.696 |
TGFBR1 |
0.842 | 0.260 | -2 | 0.865 |
BMPR2 |
0.842 | 0.146 | -2 | 0.896 |
CK2A2 |
0.841 | 0.323 | 1 | 0.772 |
ACVR2A |
0.841 | 0.309 | -2 | 0.906 |
CAMK2B |
0.841 | 0.193 | 2 | 0.832 |
PLK1 |
0.840 | 0.258 | -2 | 0.905 |
MTOR |
0.839 | -0.066 | 1 | 0.786 |
NEK7 |
0.839 | 0.079 | -3 | 0.793 |
PLK3 |
0.839 | 0.243 | 2 | 0.778 |
CAMK1B |
0.839 | 0.012 | -3 | 0.819 |
TGFBR2 |
0.838 | 0.124 | -2 | 0.920 |
RSK2 |
0.838 | 0.069 | -3 | 0.721 |
LATS1 |
0.838 | 0.211 | -3 | 0.789 |
PDHK4 |
0.837 | -0.137 | 1 | 0.853 |
TBK1 |
0.836 | -0.044 | 1 | 0.742 |
ALK4 |
0.835 | 0.199 | -2 | 0.887 |
IKKE |
0.835 | -0.023 | 1 | 0.736 |
PIM1 |
0.835 | 0.075 | -3 | 0.736 |
PKN3 |
0.835 | 0.030 | -3 | 0.771 |
ATR |
0.835 | -0.028 | 1 | 0.801 |
ATM |
0.834 | 0.085 | 1 | 0.748 |
CAMK2A |
0.834 | 0.155 | 2 | 0.847 |
ULK2 |
0.834 | -0.086 | 2 | 0.775 |
MLK1 |
0.834 | 0.004 | 2 | 0.809 |
PDHK1 |
0.833 | -0.081 | 1 | 0.841 |
KIS |
0.833 | 0.061 | 1 | 0.648 |
LATS2 |
0.832 | 0.035 | -5 | 0.729 |
SRPK1 |
0.829 | 0.035 | -3 | 0.706 |
NDR1 |
0.829 | -0.032 | -3 | 0.773 |
CDKL1 |
0.829 | -0.031 | -3 | 0.755 |
P90RSK |
0.829 | 0.007 | -3 | 0.727 |
RSK3 |
0.829 | 0.016 | -3 | 0.719 |
SKMLCK |
0.828 | -0.008 | -2 | 0.816 |
ANKRD3 |
0.828 | 0.074 | 1 | 0.848 |
NIK |
0.828 | -0.090 | -3 | 0.833 |
ULK1 |
0.828 | -0.062 | -3 | 0.782 |
CK2A1 |
0.828 | 0.270 | 1 | 0.747 |
HUNK |
0.828 | -0.055 | 2 | 0.809 |
BCKDK |
0.827 | -0.055 | -1 | 0.755 |
MST4 |
0.827 | -0.038 | 2 | 0.841 |
CAMLCK |
0.827 | -0.025 | -2 | 0.834 |
RSK4 |
0.827 | 0.077 | -3 | 0.687 |
PLK2 |
0.827 | 0.261 | -3 | 0.833 |
DLK |
0.827 | -0.010 | 1 | 0.830 |
SRPK2 |
0.827 | 0.051 | -3 | 0.636 |
P70S6KB |
0.826 | 0.017 | -3 | 0.749 |
NLK |
0.826 | -0.112 | 1 | 0.795 |
CAMK2D |
0.826 | 0.003 | -3 | 0.775 |
PKCD |
0.825 | 0.006 | 2 | 0.782 |
CHAK2 |
0.825 | -0.074 | -1 | 0.767 |
MLK3 |
0.825 | 0.033 | 2 | 0.738 |
TLK2 |
0.825 | 0.136 | 1 | 0.779 |
DAPK2 |
0.824 | -0.047 | -3 | 0.817 |
CLK2 |
0.824 | 0.125 | -3 | 0.713 |
MLK4 |
0.824 | 0.075 | 2 | 0.722 |
NUAK2 |
0.824 | -0.049 | -3 | 0.790 |
PRKX |
0.823 | 0.116 | -3 | 0.625 |
MAPKAPK2 |
0.823 | 0.034 | -3 | 0.666 |
MARK4 |
0.822 | -0.051 | 4 | 0.845 |
RIPK3 |
0.822 | -0.155 | 3 | 0.636 |
PKACG |
0.822 | -0.010 | -2 | 0.732 |
PKN2 |
0.822 | -0.050 | -3 | 0.779 |
PRKD1 |
0.821 | -0.052 | -3 | 0.745 |
MSK1 |
0.821 | 0.062 | -3 | 0.691 |
AURA |
0.821 | 0.083 | -2 | 0.654 |
YSK4 |
0.821 | 0.018 | 1 | 0.777 |
MSK2 |
0.820 | 0.011 | -3 | 0.690 |
SRPK3 |
0.820 | 0.036 | -3 | 0.688 |
AMPKA1 |
0.820 | -0.062 | -3 | 0.792 |
WNK1 |
0.819 | -0.142 | -2 | 0.806 |
AURC |
0.819 | 0.034 | -2 | 0.668 |
PRKD2 |
0.819 | -0.031 | -3 | 0.706 |
NEK9 |
0.818 | -0.139 | 2 | 0.820 |
CDK1 |
0.818 | 0.041 | 1 | 0.583 |
ERK5 |
0.818 | -0.126 | 1 | 0.727 |
BRAF |
0.818 | 0.119 | -4 | 0.831 |
GRK2 |
0.818 | 0.027 | -2 | 0.708 |
ICK |
0.818 | -0.049 | -3 | 0.780 |
PKACB |
0.817 | 0.063 | -2 | 0.682 |
PKR |
0.817 | -0.020 | 1 | 0.832 |
MEK1 |
0.817 | -0.056 | 2 | 0.837 |
TLK1 |
0.817 | 0.150 | -2 | 0.875 |
MASTL |
0.817 | -0.267 | -2 | 0.782 |
TSSK2 |
0.817 | -0.063 | -5 | 0.753 |
HIPK4 |
0.817 | -0.056 | 1 | 0.765 |
CLK4 |
0.816 | 0.033 | -3 | 0.732 |
CDKL5 |
0.816 | -0.066 | -3 | 0.740 |
GSK3A |
0.815 | 0.138 | 4 | 0.550 |
TTBK2 |
0.815 | -0.133 | 2 | 0.672 |
DNAPK |
0.815 | 0.023 | 1 | 0.674 |
PAK1 |
0.814 | -0.026 | -2 | 0.756 |
CAMK4 |
0.814 | -0.083 | -3 | 0.766 |
PASK |
0.813 | 0.095 | -3 | 0.790 |
MLK2 |
0.813 | -0.172 | 2 | 0.811 |
AMPKA2 |
0.812 | -0.066 | -3 | 0.757 |
WNK3 |
0.812 | -0.298 | 1 | 0.813 |
MAPKAPK3 |
0.812 | -0.100 | -3 | 0.707 |
TSSK1 |
0.812 | -0.070 | -3 | 0.810 |
MEKK3 |
0.812 | -0.015 | 1 | 0.786 |
PERK |
0.811 | 0.018 | -2 | 0.902 |
JNK3 |
0.810 | 0.019 | 1 | 0.615 |
GRK3 |
0.810 | 0.052 | -2 | 0.672 |
CDK8 |
0.810 | -0.052 | 1 | 0.626 |
IRE2 |
0.810 | -0.085 | 2 | 0.740 |
AURB |
0.809 | 0.009 | -2 | 0.670 |
RIPK1 |
0.808 | -0.265 | 1 | 0.817 |
DRAK1 |
0.808 | -0.053 | 1 | 0.773 |
HRI |
0.808 | -0.021 | -2 | 0.911 |
NIM1 |
0.807 | -0.170 | 3 | 0.693 |
MYLK4 |
0.807 | -0.030 | -2 | 0.751 |
CLK1 |
0.807 | 0.004 | -3 | 0.704 |
VRK2 |
0.807 | -0.273 | 1 | 0.859 |
GSK3B |
0.807 | 0.073 | 4 | 0.540 |
PKCB |
0.807 | -0.070 | 2 | 0.727 |
ZAK |
0.806 | -0.047 | 1 | 0.795 |
AKT2 |
0.806 | 0.007 | -3 | 0.649 |
QSK |
0.806 | -0.055 | 4 | 0.819 |
IRE1 |
0.806 | -0.177 | 1 | 0.783 |
DYRK2 |
0.806 | -0.037 | 1 | 0.656 |
BRSK1 |
0.806 | -0.038 | -3 | 0.737 |
PKCG |
0.806 | -0.084 | 2 | 0.727 |
NUAK1 |
0.806 | -0.090 | -3 | 0.740 |
MEKK2 |
0.805 | -0.013 | 2 | 0.795 |
PAK3 |
0.805 | -0.101 | -2 | 0.751 |
PLK4 |
0.805 | -0.054 | 2 | 0.633 |
PKCA |
0.805 | -0.066 | 2 | 0.723 |
JNK2 |
0.804 | 0.003 | 1 | 0.568 |
MEKK1 |
0.804 | -0.076 | 1 | 0.802 |
SMG1 |
0.804 | -0.115 | 1 | 0.745 |
CHK1 |
0.804 | -0.065 | -3 | 0.760 |
PRP4 |
0.804 | 0.019 | -3 | 0.747 |
PKCH |
0.804 | -0.083 | 2 | 0.718 |
CK1E |
0.804 | 0.009 | -3 | 0.601 |
PIM2 |
0.804 | -0.009 | -3 | 0.699 |
TAO3 |
0.804 | -0.001 | 1 | 0.788 |
SIK |
0.803 | -0.063 | -3 | 0.714 |
PAK2 |
0.803 | -0.080 | -2 | 0.749 |
MNK2 |
0.803 | -0.085 | -2 | 0.770 |
NEK2 |
0.803 | -0.170 | 2 | 0.792 |
CDK5 |
0.803 | -0.032 | 1 | 0.645 |
CDK2 |
0.803 | -0.033 | 1 | 0.669 |
PRKD3 |
0.802 | -0.083 | -3 | 0.693 |
MNK1 |
0.802 | -0.068 | -2 | 0.782 |
MARK2 |
0.802 | -0.040 | 4 | 0.751 |
DCAMKL1 |
0.802 | -0.046 | -3 | 0.732 |
PKCZ |
0.802 | -0.116 | 2 | 0.761 |
MARK3 |
0.802 | -0.039 | 4 | 0.786 |
SGK3 |
0.801 | -0.025 | -3 | 0.697 |
GAK |
0.801 | 0.037 | 1 | 0.822 |
PAK6 |
0.801 | -0.023 | -2 | 0.695 |
CAMK1G |
0.801 | -0.060 | -3 | 0.719 |
PINK1 |
0.801 | -0.124 | 1 | 0.813 |
PKACA |
0.801 | 0.035 | -2 | 0.634 |
CHAK1 |
0.801 | -0.202 | 2 | 0.743 |
NEK8 |
0.800 | -0.024 | 2 | 0.803 |
CDK3 |
0.800 | 0.017 | 1 | 0.523 |
PHKG1 |
0.800 | -0.122 | -3 | 0.767 |
PKG2 |
0.800 | -0.030 | -2 | 0.676 |
CK1D |
0.799 | 0.033 | -3 | 0.550 |
CDK19 |
0.799 | -0.071 | 1 | 0.581 |
MEK5 |
0.799 | -0.239 | 2 | 0.816 |
MELK |
0.799 | -0.141 | -3 | 0.742 |
CDK13 |
0.798 | -0.078 | 1 | 0.605 |
QIK |
0.798 | -0.195 | -3 | 0.775 |
NEK5 |
0.798 | -0.125 | 1 | 0.808 |
P38G |
0.798 | -0.015 | 1 | 0.494 |
MST2 |
0.797 | 0.063 | 1 | 0.780 |
P38B |
0.797 | -0.026 | 1 | 0.565 |
EEF2K |
0.797 | 0.028 | 3 | 0.753 |
TAK1 |
0.796 | 0.053 | 1 | 0.827 |
MARK1 |
0.796 | -0.065 | 4 | 0.801 |
MST3 |
0.796 | -0.093 | 2 | 0.819 |
DCAMKL2 |
0.795 | -0.060 | -3 | 0.759 |
SMMLCK |
0.795 | -0.062 | -3 | 0.765 |
CK1A2 |
0.795 | 0.016 | -3 | 0.552 |
BRSK2 |
0.795 | -0.137 | -3 | 0.756 |
P38A |
0.795 | -0.074 | 1 | 0.639 |
HIPK2 |
0.794 | -0.023 | 1 | 0.572 |
AKT1 |
0.794 | 0.005 | -3 | 0.655 |
CAMKK1 |
0.794 | -0.117 | -2 | 0.724 |
CDK7 |
0.793 | -0.116 | 1 | 0.631 |
DAPK3 |
0.793 | 0.012 | -3 | 0.752 |
CK1G1 |
0.793 | -0.020 | -3 | 0.606 |
CAMK1D |
0.793 | -0.023 | -3 | 0.639 |
P70S6K |
0.793 | -0.044 | -3 | 0.658 |
HIPK1 |
0.792 | -0.051 | 1 | 0.677 |
P38D |
0.791 | 0.002 | 1 | 0.511 |
DYRK4 |
0.791 | -0.013 | 1 | 0.582 |
SNRK |
0.791 | -0.233 | 2 | 0.678 |
GCK |
0.791 | -0.040 | 1 | 0.768 |
ERK2 |
0.791 | -0.086 | 1 | 0.612 |
MAPKAPK5 |
0.791 | -0.164 | -3 | 0.665 |
CDK18 |
0.790 | -0.071 | 1 | 0.556 |
ERK1 |
0.790 | -0.064 | 1 | 0.559 |
TAO2 |
0.790 | -0.123 | 2 | 0.835 |
CDK12 |
0.789 | -0.084 | 1 | 0.576 |
PKCT |
0.789 | -0.099 | 2 | 0.724 |
DYRK1A |
0.789 | -0.069 | 1 | 0.702 |
JNK1 |
0.788 | -0.003 | 1 | 0.567 |
TTK |
0.788 | 0.186 | -2 | 0.923 |
CAMKK2 |
0.788 | -0.129 | -2 | 0.716 |
DAPK1 |
0.788 | 0.002 | -3 | 0.738 |
CDK17 |
0.788 | -0.068 | 1 | 0.504 |
WNK4 |
0.788 | -0.241 | -2 | 0.809 |
SSTK |
0.787 | -0.097 | 4 | 0.803 |
PDK1 |
0.787 | -0.094 | 1 | 0.832 |
ALPHAK3 |
0.787 | 0.161 | -1 | 0.739 |
TTBK1 |
0.786 | -0.174 | 2 | 0.593 |
TNIK |
0.786 | -0.056 | 3 | 0.759 |
DYRK3 |
0.786 | -0.035 | 1 | 0.683 |
LKB1 |
0.786 | -0.163 | -3 | 0.779 |
SGK1 |
0.785 | 0.018 | -3 | 0.564 |
MST1 |
0.785 | -0.025 | 1 | 0.767 |
DYRK1B |
0.785 | -0.053 | 1 | 0.604 |
IRAK4 |
0.784 | -0.248 | 1 | 0.792 |
NEK11 |
0.784 | -0.239 | 1 | 0.791 |
PAK5 |
0.784 | -0.055 | -2 | 0.645 |
PKCI |
0.784 | -0.112 | 2 | 0.730 |
MINK |
0.783 | -0.103 | 1 | 0.771 |
AKT3 |
0.783 | 0.010 | -3 | 0.578 |
PHKG2 |
0.783 | -0.131 | -3 | 0.750 |
OSR1 |
0.783 | 0.068 | 2 | 0.788 |
PAK4 |
0.783 | -0.033 | -2 | 0.653 |
CDK9 |
0.783 | -0.131 | 1 | 0.611 |
PKCE |
0.782 | -0.057 | 2 | 0.714 |
MRCKA |
0.782 | -0.011 | -3 | 0.702 |
HGK |
0.781 | -0.119 | 3 | 0.754 |
MPSK1 |
0.781 | -0.157 | 1 | 0.776 |
SLK |
0.780 | -0.087 | -2 | 0.690 |
ERK7 |
0.780 | -0.039 | 2 | 0.539 |
PDHK3_TYR |
0.780 | 0.306 | 4 | 0.908 |
CDK10 |
0.779 | -0.059 | 1 | 0.585 |
CDK16 |
0.779 | -0.054 | 1 | 0.525 |
LRRK2 |
0.778 | -0.225 | 2 | 0.831 |
ROCK2 |
0.778 | -0.022 | -3 | 0.726 |
HPK1 |
0.778 | -0.131 | 1 | 0.752 |
CDK14 |
0.778 | -0.099 | 1 | 0.600 |
MRCKB |
0.777 | -0.031 | -3 | 0.687 |
HIPK3 |
0.777 | -0.119 | 1 | 0.667 |
IRAK1 |
0.777 | -0.333 | -1 | 0.650 |
VRK1 |
0.776 | -0.203 | 2 | 0.817 |
NEK4 |
0.775 | -0.257 | 1 | 0.766 |
MAP2K6_TYR |
0.775 | 0.264 | -1 | 0.825 |
KHS2 |
0.775 | -0.067 | 1 | 0.760 |
LOK |
0.774 | -0.156 | -2 | 0.741 |
MEK2 |
0.774 | -0.220 | 2 | 0.800 |
PDHK4_TYR |
0.774 | 0.211 | 2 | 0.883 |
NEK1 |
0.774 | -0.226 | 1 | 0.790 |
PKN1 |
0.774 | -0.080 | -3 | 0.674 |
MAP3K15 |
0.773 | -0.242 | 1 | 0.778 |
DMPK1 |
0.773 | 0.010 | -3 | 0.712 |
KHS1 |
0.773 | -0.116 | 1 | 0.755 |
CAMK1A |
0.773 | -0.049 | -3 | 0.606 |
BMPR2_TYR |
0.772 | 0.194 | -1 | 0.829 |
CHK2 |
0.772 | -0.078 | -3 | 0.595 |
STK33 |
0.772 | -0.189 | 2 | 0.604 |
RIPK2 |
0.770 | -0.256 | 1 | 0.759 |
SBK |
0.770 | -0.028 | -3 | 0.533 |
YSK1 |
0.770 | -0.163 | 2 | 0.791 |
PDHK1_TYR |
0.769 | 0.189 | -1 | 0.832 |
MAP2K4_TYR |
0.769 | 0.136 | -1 | 0.802 |
YANK3 |
0.768 | -0.041 | 2 | 0.385 |
MAK |
0.767 | -0.032 | -2 | 0.680 |
MEKK6 |
0.767 | -0.324 | 1 | 0.764 |
CDK6 |
0.767 | -0.085 | 1 | 0.581 |
PBK |
0.765 | -0.119 | 1 | 0.730 |
CDK4 |
0.764 | -0.091 | 1 | 0.565 |
CRIK |
0.764 | -0.012 | -3 | 0.643 |
EPHA6 |
0.764 | 0.144 | -1 | 0.832 |
TESK1_TYR |
0.764 | -0.079 | 3 | 0.787 |
ROCK1 |
0.763 | -0.040 | -3 | 0.700 |
CK1A |
0.762 | -0.002 | -3 | 0.472 |
MAP2K7_TYR |
0.761 | -0.133 | 2 | 0.860 |
PINK1_TYR |
0.760 | -0.094 | 1 | 0.849 |
BUB1 |
0.760 | -0.115 | -5 | 0.697 |
ASK1 |
0.758 | -0.189 | 1 | 0.779 |
MOK |
0.758 | -0.085 | 1 | 0.673 |
MYO3A |
0.758 | -0.113 | 1 | 0.764 |
HASPIN |
0.757 | -0.095 | -1 | 0.597 |
PKG1 |
0.756 | -0.075 | -2 | 0.603 |
MYO3B |
0.756 | -0.144 | 2 | 0.802 |
BIKE |
0.756 | -0.061 | 1 | 0.695 |
EPHA4 |
0.756 | 0.115 | 2 | 0.783 |
EPHB4 |
0.755 | 0.084 | -1 | 0.798 |
FLT1 |
0.755 | 0.173 | -1 | 0.855 |
PKMYT1_TYR |
0.755 | -0.216 | 3 | 0.755 |
NEK3 |
0.755 | -0.273 | 1 | 0.754 |
INSRR |
0.754 | 0.084 | 3 | 0.625 |
STLK3 |
0.753 | -0.122 | 1 | 0.748 |
JAK3 |
0.753 | 0.064 | 1 | 0.803 |
TAO1 |
0.753 | -0.167 | 1 | 0.727 |
CK1G3 |
0.752 | 0.030 | -3 | 0.428 |
RET |
0.752 | -0.093 | 1 | 0.802 |
TXK |
0.752 | 0.099 | 1 | 0.822 |
FGFR2 |
0.749 | 0.033 | 3 | 0.687 |
DDR1 |
0.749 | -0.109 | 4 | 0.836 |
EPHB2 |
0.748 | 0.115 | -1 | 0.782 |
FER |
0.748 | -0.028 | 1 | 0.854 |
LIMK2_TYR |
0.747 | -0.203 | -3 | 0.822 |
FGR |
0.747 | -0.047 | 1 | 0.805 |
EPHB1 |
0.746 | 0.039 | 1 | 0.827 |
CSF1R |
0.745 | -0.087 | 3 | 0.650 |
MST1R |
0.745 | -0.160 | 3 | 0.678 |
SYK |
0.745 | 0.184 | -1 | 0.794 |
YES1 |
0.745 | -0.046 | -1 | 0.703 |
TYK2 |
0.744 | -0.205 | 1 | 0.800 |
LIMK1_TYR |
0.744 | -0.286 | 2 | 0.842 |
KIT |
0.743 | -0.042 | 3 | 0.660 |
PTK2 |
0.743 | 0.149 | -1 | 0.825 |
FLT3 |
0.743 | -0.054 | 3 | 0.658 |
FGFR3 |
0.743 | 0.037 | 3 | 0.659 |
SRMS |
0.743 | -0.024 | 1 | 0.840 |
BLK |
0.742 | 0.046 | -1 | 0.725 |
EPHB3 |
0.742 | 0.010 | -1 | 0.777 |
KDR |
0.742 | -0.039 | 3 | 0.622 |
CK1G2 |
0.742 | 0.029 | -3 | 0.521 |
JAK2 |
0.741 | -0.182 | 1 | 0.796 |
ABL2 |
0.741 | -0.083 | -1 | 0.709 |
LCK |
0.741 | -0.009 | -1 | 0.715 |
ROS1 |
0.740 | -0.195 | 3 | 0.632 |
EGFR |
0.740 | 0.075 | 1 | 0.696 |
FYN |
0.740 | 0.057 | -1 | 0.686 |
TYRO3 |
0.740 | -0.220 | 3 | 0.664 |
EPHA5 |
0.740 | 0.106 | 2 | 0.774 |
HCK |
0.738 | -0.092 | -1 | 0.708 |
PDGFRB |
0.738 | -0.125 | 3 | 0.667 |
FGFR1 |
0.737 | -0.072 | 3 | 0.636 |
EPHA7 |
0.737 | 0.007 | 2 | 0.777 |
MET |
0.737 | -0.047 | 3 | 0.643 |
FLT4 |
0.737 | -0.022 | 3 | 0.633 |
NEK10_TYR |
0.736 | -0.130 | 1 | 0.713 |
EPHA3 |
0.736 | -0.021 | 2 | 0.755 |
ERBB2 |
0.735 | -0.064 | 1 | 0.777 |
YANK2 |
0.735 | -0.069 | 2 | 0.406 |
ABL1 |
0.735 | -0.131 | -1 | 0.690 |
NTRK1 |
0.734 | -0.070 | -1 | 0.770 |
ITK |
0.734 | -0.093 | -1 | 0.684 |
AAK1 |
0.734 | -0.042 | 1 | 0.581 |
FGFR4 |
0.732 | 0.026 | -1 | 0.733 |
EPHA8 |
0.732 | 0.012 | -1 | 0.760 |
TEC |
0.731 | -0.091 | -1 | 0.590 |
TEK |
0.730 | -0.196 | 3 | 0.603 |
BMX |
0.730 | -0.084 | -1 | 0.599 |
PTK6 |
0.729 | -0.161 | -1 | 0.608 |
INSR |
0.729 | -0.068 | 3 | 0.603 |
WEE1_TYR |
0.729 | -0.152 | -1 | 0.637 |
DDR2 |
0.729 | -0.044 | 3 | 0.618 |
TNNI3K_TYR |
0.728 | -0.136 | 1 | 0.787 |
FRK |
0.728 | -0.081 | -1 | 0.733 |
MERTK |
0.728 | -0.155 | 3 | 0.634 |
NTRK2 |
0.728 | -0.117 | 3 | 0.622 |
LYN |
0.727 | -0.074 | 3 | 0.593 |
BTK |
0.727 | -0.211 | -1 | 0.624 |
EPHA2 |
0.727 | 0.053 | -1 | 0.767 |
NTRK3 |
0.726 | -0.089 | -1 | 0.724 |
LTK |
0.726 | -0.158 | 3 | 0.614 |
TNK2 |
0.726 | -0.238 | 3 | 0.622 |
PDGFRA |
0.726 | -0.239 | 3 | 0.661 |
ALK |
0.726 | -0.169 | 3 | 0.586 |
JAK1 |
0.725 | -0.186 | 1 | 0.749 |
AXL |
0.723 | -0.254 | 3 | 0.635 |
SRC |
0.723 | -0.067 | -1 | 0.670 |
ERBB4 |
0.723 | 0.024 | 1 | 0.697 |
MATK |
0.723 | -0.117 | -1 | 0.656 |
IGF1R |
0.723 | -0.021 | 3 | 0.553 |
TNK1 |
0.722 | -0.275 | 3 | 0.650 |
CSK |
0.720 | -0.125 | 2 | 0.777 |
EPHA1 |
0.719 | -0.195 | 3 | 0.608 |
PTK2B |
0.718 | -0.131 | -1 | 0.626 |
ZAP70 |
0.712 | 0.008 | -1 | 0.685 |
MUSK |
0.707 | -0.170 | 1 | 0.674 |
FES |
0.692 | -0.178 | -1 | 0.575 |