Motif 573 (n=138)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L162 | ERICH2 | T63 | ochoa | Glutamate-rich protein 2 | None |
| A6NCL7 | ANKRD33B | S44 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| E9PAV3 | NACA | S1906 | psp | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00418 | EEF2K | S464 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O00533 | CHL1 | S1147 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| O00629 | KPNA4 | S72 | ochoa | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Mediates nuclear import of AARS1, MRTFA and RANBP3 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:38512451). {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:28760339, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:38512451}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| O43463 | SUV39H1 | S381 | ochoa | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126, ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776, ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:30111536}.; FUNCTION: (Microbial infection) Plays a role in defense against mycobacterial infections. Methylates M.tuberculosis HupB on 'Lys-140', probably methylates HupB of M.bovis also. Methylation has an inhibitory effect on mycobacterial growth in the host. Macrophages expressing about 60% SUV39H1 are slightly more susceptible to M.bovis or M.tuberculosis infection. Chaetocin (an inhibitor of this enzyme) increases macrophage survival of M.tuberculosis. This protein inhibits biofilm formation by M.tuberculosis via 'Lys-140' trimethylation. {ECO:0000269|PubMed:29170282}. |
| O43815 | STRN | S259 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43815 | STRN | T263 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60331 | PIP5K1C | S650 | psp | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| O60343 | TBC1D4 | S314 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60841 | EIF5B | S121 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60927 | PPP1R11 | S57 | ochoa | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}. |
| O60934 | NBN | S612 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75122 | CLASP2 | S1057 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75717 | WDHD1 | S367 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O94832 | MYO1D | S298 | ochoa | Unconventional myosin-Id | Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}. |
| O94880 | PHF14 | S246 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95810 | CAVIN2 | S218 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P08172 | CHRM2 | S311 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P10451 | SPP1 | S117 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S120 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S123 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10451 | SPP1 | S126 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10636 | MAPT | S232 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10914 | IRF1 | S282 | ochoa | Interferon regulatory factor 1 (IRF-1) | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essentail role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}. |
| P11277 | SPTB | S35 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P16220 | CREB1 | S107 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
| P18206 | VCL | S443 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18583 | SON | S160 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19338 | NCL | S41 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20810 | CAST | S577 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23588 | EIF4B | S57 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S192 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23759 | PAX7 | S207 | ochoa | Paired box protein Pax-7 (HuP1) | Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. {ECO:0000269|PubMed:31092906}. |
| P23760 | PAX3 | S209 | ochoa | Paired box protein Pax-3 (HuP2) | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}. |
| P26232 | CTNNA2 | S651 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27348 | YWHAQ | S214 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31327 | CPS1 | S848 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31946 | YWHAB | S216 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S216 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P35221 | CTNNA1 | S652 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P38398 | BRCA1 | S1164 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46821 | MAP1B | S1899 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P51149 | RAB7A | S111 | ochoa | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
| P54819 | AK2 | S176 | ochoa | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| P55196 | AFDN | T1590 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P61981 | YWHAG | S219 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S217 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S214 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P98175 | RBM10 | S69 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q03164 | KMT2A | S2833 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03188 | CENPC | S713 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04917 | YWHAH | S219 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q12830 | BPTF | S1133 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12872 | SFSWAP | S618 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13009 | TIAM1 | S1532 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13586 | STIM1 | S486 | psp | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14149 | MORC3 | S584 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14571 | ITPR2 | S1014 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q15398 | DLGAP5 | S806 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q27J81 | INF2 | S1188 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q27J81 | INF2 | S1201 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q3YEC7 | RABL6 | S454 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
| Q5JSZ5 | PRRC2B | S999 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SSJ5 | HP1BP3 | S446 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T200 | ZC3H13 | S1409 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T4S7 | UBR4 | S2743 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5UIP0 | RIF1 | S1149 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q659A1 | ICE2 | S496 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q6NT76 | HMBOX1 | S170 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q6WKZ4 | RAB11FIP1 | S389 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZMW3 | EML6 | S1296 | ochoa | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}. |
| Q6ZUJ8 | PIK3AP1 | S759 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q76FK4 | NOL8 | S378 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z2Z1 | TICRR | S1881 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3G6 | PRICKLE2 | S543 | ochoa | Prickle-like protein 2 | None |
| Q7Z3K6 | MIER3 | S165 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | S2391 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U86 | PBRM1 | S1119 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UZ6 | ZBTB46 | S326 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86V15 | CASZ1 | S1719 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86VR2 | RETREG3 | S285 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86X53 | ERICH1 | S238 | ochoa | Glutamate-rich protein 1 | None |
| Q8IVF5 | TIAM2 | S1583 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8N108 | MIER1 | S131 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N157 | AHI1 | S331 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8ND24 | RNF214 | S200 | ochoa | RING finger protein 214 | None |
| Q8NFC6 | BOD1L1 | S266 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TCU6 | PREX1 | S1169 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8WU17 | RNF139 | S634 | ochoa | E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) | E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569}. |
| Q8WWQ0 | PHIP | S1296 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92614 | MYO18A | S403 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92785 | DPF2 | S151 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92797 | SYMPK | S1221 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96CW6 | SLC7A6OS | S258 | ochoa | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q96GX5 | MASTL | S602 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96JG6 | VPS50 | Y571 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
| Q96K31 | C8orf76 | S25 | ochoa | Uncharacterized protein C8orf76 | None |
| Q96K49 | TMEM87B | S522 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96MY1 | NOL4L | S179 | ochoa | Nucleolar protein 4-like | None |
| Q96SI9 | STRBP | S474 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
| Q96SU4 | OSBPL9 | S304 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q9C0D0 | PHACTR1 | S177 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9H0H5 | RACGAP1 | S169 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H1E3 | NUCKS1 | S30 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2G2 | SLK | S446 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H501 | ESF1 | S298 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H6T3 | RPAP3 | S119 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H8T0 | AKTIP | S237 | psp | AKT-interacting protein (Ft1) (Fused toes protein homolog) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9HAZ2 | PRDM16 | S1133 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HC44 | GPBP1L1 | S353 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9HCK8 | CHD8 | S562 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HD67 | MYO10 | S1007 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9NR09 | BIRC6 | S490 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRL3 | STRN4 | S284 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9P0K7 | RAI14 | S335 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9UDY2 | TJP2 | S415 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UEY8 | ADD3 | S647 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | S698 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHH9 | IP6K2 | S359 | psp | Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}. |
| Q9UJU5 | FOXD3 | S46 | ochoa | Forkhead box protein D3 (HNF3/FH transcription factor genesis) | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:11891324). Also acts as a transcriptional activator (PubMed:11891324). Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). Promotes development of neural crest cells from neural tube progenitors (PubMed:11891324). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:11891324). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:11891324). {ECO:0000269|PubMed:11891324, ECO:0000269|PubMed:22306510}. |
| Q9Y2W1 | THRAP3 | S584 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y450 | HBS1L | S33 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y450 | HBS1L | S69 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y5T5 | USP16 | S423 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y6D6 | ARFGEF1 | S289 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6J0 | CABIN1 | S1752 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6R1 | SLC4A4 | S77 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6R4 | MAP3K4 | S84 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| Q14247 | CTTN | S331 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q8WVC0 | LEO1 | S75 | Sugiyama | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| O94768 | STK17B | S347 | Sugiyama | Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) | Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}. |
| Q15906 | VPS72 | S71 | ELM | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| P62081 | RPS7 | S137 | Sugiyama | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q13765 | NACA | S43 | SIGNOR|ELM|iPTMNet|EPSD | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| Q8IW41 | MAPKAPK5 | S386 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q6ULP2 | AFTPH | S582 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 9.709658e-10 | 9.013 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 4.528975e-10 | 9.344 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 9.709658e-10 | 9.013 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 9.709658e-10 | 9.013 |
| R-HSA-114452 | Activation of BH3-only proteins | 7.433516e-08 | 7.129 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 9.188209e-08 | 7.037 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.254235e-07 | 6.902 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 3.014546e-07 | 6.521 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.393325e-06 | 5.856 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.021793e-06 | 5.520 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.338712e-06 | 5.476 |
| R-HSA-69481 | G2/M Checkpoints | 1.082049e-05 | 4.966 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.100918e-05 | 4.678 |
| R-HSA-5357801 | Programmed Cell Death | 7.012313e-05 | 4.154 |
| R-HSA-109581 | Apoptosis | 6.731822e-05 | 4.172 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.501449e-05 | 4.071 |
| R-HSA-9834899 | Specification of the neural plate border | 9.302758e-05 | 4.031 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.573538e-04 | 3.589 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.111942e-04 | 3.214 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.604266e-04 | 3.065 |
| R-HSA-2028269 | Signaling by Hippo | 1.304882e-03 | 2.884 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.580170e-03 | 2.588 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.838310e-03 | 2.547 |
| R-HSA-1266738 | Developmental Biology | 3.490846e-03 | 2.457 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 4.267179e-03 | 2.370 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 4.267179e-03 | 2.370 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.342116e-03 | 2.362 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.131150e-03 | 2.290 |
| R-HSA-199991 | Membrane Trafficking | 5.169753e-03 | 2.287 |
| R-HSA-9700645 | ALK mutants bind TKIs | 6.068514e-03 | 2.217 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.903353e-03 | 2.102 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.941518e-03 | 2.100 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.131938e-02 | 1.946 |
| R-HSA-165159 | MTOR signalling | 1.261921e-02 | 1.899 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.894628e-02 | 1.722 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.894628e-02 | 1.722 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.916833e-02 | 1.717 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.757382e-02 | 1.755 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.701333e-02 | 1.769 |
| R-HSA-4839726 | Chromatin organization | 1.543419e-02 | 1.812 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 1.757382e-02 | 1.755 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.253151e-02 | 1.647 |
| R-HSA-392517 | Rap1 signalling | 2.253151e-02 | 1.647 |
| R-HSA-1640170 | Cell Cycle | 2.333192e-02 | 1.632 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.189048e-02 | 1.660 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.429771e-02 | 1.614 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.429771e-02 | 1.614 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.429771e-02 | 1.614 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.429771e-02 | 1.614 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.404266e-02 | 1.619 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.628946e-02 | 1.580 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.828524e-02 | 1.548 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.839873e-02 | 1.547 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.600462e-02 | 1.444 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.813002e-02 | 1.419 |
| R-HSA-525793 | Myogenesis | 3.813002e-02 | 1.419 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.600462e-02 | 1.444 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.600462e-02 | 1.444 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.392713e-02 | 1.469 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.392713e-02 | 1.469 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.030226e-02 | 1.395 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.618778e-02 | 1.441 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.611750e-02 | 1.442 |
| R-HSA-74160 | Gene expression (Transcription) | 3.843260e-02 | 1.415 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.669902e-02 | 1.331 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.367163e-02 | 1.133 |
| R-HSA-447041 | CHL1 interactions | 9.123074e-02 | 1.040 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 9.123074e-02 | 1.040 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 9.988589e-02 | 1.000 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 9.988589e-02 | 1.000 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.336951e-01 | 0.874 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.419484e-01 | 0.848 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.501235e-01 | 0.824 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.501235e-01 | 0.824 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.478297e-02 | 1.349 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.820575e-01 | 0.740 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.127990e-01 | 0.672 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.497455e-02 | 1.022 |
| R-HSA-429947 | Deadenylation of mRNA | 2.496163e-01 | 0.603 |
| R-HSA-72649 | Translation initiation complex formation | 1.193216e-01 | 0.923 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.256310e-01 | 0.901 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.482951e-01 | 0.829 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.482951e-01 | 0.829 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.582480e-01 | 0.801 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.086866e-01 | 0.964 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.819175e-01 | 0.740 |
| R-HSA-380287 | Centrosome maturation | 1.887759e-01 | 0.724 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.270287e-01 | 0.644 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.270287e-01 | 0.644 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.375688e-01 | 0.624 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.481347e-01 | 0.605 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.021112e-02 | 1.154 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.095475e-01 | 0.679 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.352398e-01 | 0.869 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.060008e-02 | 1.094 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.497455e-02 | 1.022 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.497455e-02 | 1.022 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.615933e-01 | 0.792 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.549162e-01 | 0.810 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.336951e-01 | 0.874 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.924087e-02 | 1.227 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.497455e-02 | 1.022 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.235228e-01 | 0.651 |
| R-HSA-199920 | CREB phosphorylation | 8.249292e-02 | 1.084 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.084591e-01 | 0.965 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.820575e-01 | 0.740 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.708802e-01 | 0.567 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.253036e-01 | 0.647 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.426028e-02 | 1.266 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.699254e-02 | 1.174 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.060008e-02 | 1.094 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.778342e-01 | 0.556 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.673123e-02 | 1.246 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.638596e-01 | 0.579 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.293371e-01 | 0.888 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.426028e-02 | 1.266 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.293371e-01 | 0.888 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.869440e-01 | 0.542 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.450070e-01 | 0.839 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.615933e-01 | 0.792 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.005939e-01 | 0.698 |
| R-HSA-9636569 | Suppression of autophagy | 6.476608e-02 | 1.189 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 9.123074e-02 | 1.040 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 1.582213e-01 | 0.801 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.924087e-02 | 1.227 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.496163e-01 | 0.603 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.320184e-01 | 0.879 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.708802e-01 | 0.567 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.352398e-01 | 0.869 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.683221e-01 | 0.774 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.622458e-01 | 0.581 |
| R-HSA-170968 | Frs2-mediated activation | 1.501235e-01 | 0.824 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.084591e-01 | 0.965 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.288152e-01 | 0.890 |
| R-HSA-1500620 | Meiosis | 2.235228e-01 | 0.651 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.975745e-01 | 0.704 |
| R-HSA-9843745 | Adipogenesis | 1.672479e-01 | 0.777 |
| R-HSA-169893 | Prolonged ERK activation events | 1.741875e-01 | 0.759 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.423924e-01 | 0.615 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 6.476608e-02 | 1.189 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.169513e-01 | 0.932 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.582213e-01 | 0.801 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.662424e-01 | 0.779 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 6.964762e-02 | 1.157 |
| R-HSA-912446 | Meiotic recombination | 1.100157e-01 | 0.959 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.235228e-01 | 0.651 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.478297e-02 | 1.349 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.450070e-01 | 0.839 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.697773e-02 | 1.114 |
| R-HSA-205025 | NADE modulates death signalling | 5.577548e-02 | 1.254 |
| R-HSA-170984 | ARMS-mediated activation | 1.084591e-01 | 0.965 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.582213e-01 | 0.801 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.662424e-01 | 0.779 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.052230e-01 | 0.688 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.060678e-01 | 0.686 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.200213e-01 | 0.658 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.904677e-01 | 0.537 |
| R-HSA-68877 | Mitotic Prometaphase | 1.466779e-01 | 0.834 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.753190e-01 | 0.560 |
| R-HSA-5578775 | Ion homeostasis | 1.256310e-01 | 0.901 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.178826e-02 | 1.209 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 6.699254e-02 | 1.174 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 7.505915e-02 | 1.125 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 7.505915e-02 | 1.125 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.203033e-01 | 0.657 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.445550e-01 | 0.840 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 9.204322e-02 | 1.036 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 9.123074e-02 | 1.040 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.084591e-01 | 0.965 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.169513e-01 | 0.932 |
| R-HSA-425381 | Bicarbonate transporters | 1.253630e-01 | 0.902 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.662424e-01 | 0.779 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.419484e-01 | 0.848 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.582480e-01 | 0.801 |
| R-HSA-9675135 | Diseases of DNA repair | 9.497455e-02 | 1.022 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.367163e-02 | 1.133 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.084591e-01 | 0.965 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.741875e-01 | 0.759 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.626268e-01 | 0.789 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.378768e-01 | 0.624 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.847224e-01 | 0.546 |
| R-HSA-1489509 | DAG and IP3 signaling | 9.204322e-02 | 1.036 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.023626e-02 | 1.299 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.125463e-01 | 0.949 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.278078e-01 | 0.642 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.501235e-01 | 0.824 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.582213e-01 | 0.801 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.567719e-01 | 0.590 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.638596e-01 | 0.579 |
| R-HSA-112043 | PLC beta mediated events | 1.417347e-01 | 0.849 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.169513e-01 | 0.932 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.785028e-01 | 0.748 |
| R-HSA-166520 | Signaling by NTRKs | 2.128693e-01 | 0.672 |
| R-HSA-2559583 | Cellular Senescence | 2.969562e-01 | 0.527 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.847224e-01 | 0.546 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.270287e-01 | 0.644 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.839898e-01 | 0.547 |
| R-HSA-3214847 | HATs acetylate histones | 2.834185e-01 | 0.548 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.340520e-01 | 0.631 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.741875e-01 | 0.759 |
| R-HSA-70635 | Urea cycle | 2.638596e-01 | 0.579 |
| R-HSA-112040 | G-protein mediated events | 1.615933e-01 | 0.792 |
| R-HSA-418990 | Adherens junctions interactions | 1.947152e-01 | 0.711 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.542151e-01 | 0.595 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.288152e-01 | 0.890 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.481347e-01 | 0.605 |
| R-HSA-421270 | Cell-cell junction organization | 2.614296e-01 | 0.583 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.052230e-01 | 0.688 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.708802e-01 | 0.567 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.450070e-01 | 0.839 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.762342e-01 | 0.559 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.988589e-02 | 1.000 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.988589e-02 | 1.000 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.084591e-01 | 0.965 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.496163e-01 | 0.603 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.638596e-01 | 0.579 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.788171e-01 | 0.555 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.788171e-01 | 0.555 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.336245e-01 | 0.874 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.708934e-02 | 1.327 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.052230e-01 | 0.688 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.203033e-01 | 0.657 |
| R-HSA-422475 | Axon guidance | 1.764368e-01 | 0.753 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.277365e-01 | 0.643 |
| R-HSA-5620971 | Pyroptosis | 2.778342e-01 | 0.556 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.375688e-01 | 0.624 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.708802e-01 | 0.567 |
| R-HSA-9675108 | Nervous system development | 2.214365e-01 | 0.655 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.372982e-02 | 1.196 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.638596e-01 | 0.579 |
| R-HSA-1989781 | PPARA activates gene expression | 2.303174e-01 | 0.638 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.871824e-02 | 1.104 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.939893e-01 | 0.532 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.662293e-01 | 0.575 |
| R-HSA-1280218 | Adaptive Immune System | 1.433876e-01 | 0.843 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.023626e-02 | 1.299 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.353520e-01 | 0.628 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.500130e-02 | 1.022 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.233678e-02 | 1.141 |
| R-HSA-162582 | Signal Transduction | 6.858006e-02 | 1.164 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.638596e-01 | 0.579 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 6.964762e-02 | 1.157 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.423924e-01 | 0.615 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.224662e-01 | 0.912 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.182900e-02 | 1.285 |
| R-HSA-212436 | Generic Transcription Pathway | 1.725708e-01 | 0.763 |
| R-HSA-913531 | Interferon Signaling | 1.917399e-01 | 0.717 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.372982e-02 | 1.196 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.066979e-01 | 0.972 |
| R-HSA-9758941 | Gastrulation | 7.740563e-02 | 1.111 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.355935e-02 | 1.133 |
| R-HSA-157118 | Signaling by NOTCH | 2.386404e-01 | 0.622 |
| R-HSA-75153 | Apoptotic execution phase | 9.497455e-02 | 1.022 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.066979e-01 | 0.972 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.763636e-01 | 0.559 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.429405e-01 | 0.615 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.884984e-01 | 0.725 |
| R-HSA-73887 | Death Receptor Signaling | 8.407947e-02 | 1.075 |
| R-HSA-9679506 | SARS-CoV Infections | 1.881706e-01 | 0.725 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.983035e-01 | 0.525 |
| R-HSA-111885 | Opioid Signalling | 3.010254e-01 | 0.521 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.047545e-01 | 0.516 |
| R-HSA-418346 | Platelet homeostasis | 3.115576e-01 | 0.506 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.116283e-01 | 0.506 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.116283e-01 | 0.506 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.116283e-01 | 0.506 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.116283e-01 | 0.506 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.116283e-01 | 0.506 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.116283e-01 | 0.506 |
| R-HSA-69275 | G2/M Transition | 3.125622e-01 | 0.505 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.177709e-01 | 0.498 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.181962e-01 | 0.497 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.181962e-01 | 0.497 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.181962e-01 | 0.497 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.185613e-01 | 0.497 |
| R-HSA-446728 | Cell junction organization | 3.188622e-01 | 0.496 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.220571e-01 | 0.492 |
| R-HSA-5617833 | Cilium Assembly | 3.229814e-01 | 0.491 |
| R-HSA-5673000 | RAF activation | 3.247018e-01 | 0.489 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.247018e-01 | 0.489 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.247018e-01 | 0.489 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.247018e-01 | 0.489 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.274837e-01 | 0.485 |
| R-HSA-187687 | Signalling to ERKs | 3.311457e-01 | 0.480 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.311457e-01 | 0.480 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.375285e-01 | 0.472 |
| R-HSA-3371511 | HSF1 activation | 3.375285e-01 | 0.472 |
| R-HSA-111933 | Calmodulin induced events | 3.375285e-01 | 0.472 |
| R-HSA-111997 | CaM pathway | 3.375285e-01 | 0.472 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.386131e-01 | 0.470 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.394663e-01 | 0.469 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.394663e-01 | 0.469 |
| R-HSA-68886 | M Phase | 3.423044e-01 | 0.466 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.438508e-01 | 0.464 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.490254e-01 | 0.457 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.498479e-01 | 0.456 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.501132e-01 | 0.456 |
| R-HSA-373760 | L1CAM interactions | 3.532966e-01 | 0.452 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.555851e-01 | 0.449 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.563161e-01 | 0.448 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.563161e-01 | 0.448 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.563161e-01 | 0.448 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.567389e-01 | 0.448 |
| R-HSA-5693538 | Homology Directed Repair | 3.601748e-01 | 0.443 |
| R-HSA-195721 | Signaling by WNT | 3.620767e-01 | 0.441 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.624603e-01 | 0.441 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.624603e-01 | 0.441 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.685462e-01 | 0.434 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.685462e-01 | 0.434 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.685462e-01 | 0.434 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.704417e-01 | 0.431 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.745743e-01 | 0.426 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.745743e-01 | 0.426 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.772506e-01 | 0.423 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.805453e-01 | 0.420 |
| R-HSA-111996 | Ca-dependent events | 3.805453e-01 | 0.420 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.805453e-01 | 0.420 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.805453e-01 | 0.420 |
| R-HSA-397014 | Muscle contraction | 3.827227e-01 | 0.417 |
| R-HSA-8854214 | TBC/RABGAPs | 3.864596e-01 | 0.413 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.864596e-01 | 0.413 |
| R-HSA-194138 | Signaling by VEGF | 3.874070e-01 | 0.412 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.907766e-01 | 0.408 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.923179e-01 | 0.406 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.923179e-01 | 0.406 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.923179e-01 | 0.406 |
| R-HSA-373752 | Netrin-1 signaling | 3.923179e-01 | 0.406 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.974911e-01 | 0.401 |
| R-HSA-774815 | Nucleosome assembly | 3.981205e-01 | 0.400 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.981205e-01 | 0.400 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.981205e-01 | 0.400 |
| R-HSA-1500931 | Cell-Cell communication | 4.009381e-01 | 0.397 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.038681e-01 | 0.394 |
| R-HSA-1474165 | Reproduction | 4.074990e-01 | 0.390 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.095309e-01 | 0.388 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.095612e-01 | 0.388 |
| R-HSA-5576891 | Cardiac conduction | 4.108174e-01 | 0.386 |
| R-HSA-9909396 | Circadian clock | 4.141267e-01 | 0.383 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.141267e-01 | 0.383 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.152002e-01 | 0.382 |
| R-HSA-9824446 | Viral Infection Pathways | 4.180555e-01 | 0.379 |
| R-HSA-9766229 | Degradation of CDH1 | 4.207858e-01 | 0.376 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.207858e-01 | 0.376 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.337862e-01 | 0.363 |
| R-HSA-8953854 | Metabolism of RNA | 4.341237e-01 | 0.362 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.370290e-01 | 0.359 |
| R-HSA-72187 | mRNA 3'-end processing | 4.372264e-01 | 0.359 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.372264e-01 | 0.359 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.372264e-01 | 0.359 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.372264e-01 | 0.359 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.393831e-01 | 0.357 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.426029e-01 | 0.354 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.426029e-01 | 0.354 |
| R-HSA-1221632 | Meiotic synapsis | 4.426029e-01 | 0.354 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.426029e-01 | 0.354 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.479283e-01 | 0.349 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.687294e-01 | 0.329 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.788360e-01 | 0.320 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.788360e-01 | 0.320 |
| R-HSA-983189 | Kinesins | 4.788360e-01 | 0.320 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.838175e-01 | 0.315 |
| R-HSA-450294 | MAP kinase activation | 4.838175e-01 | 0.315 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.844199e-01 | 0.315 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.887516e-01 | 0.311 |
| R-HSA-9707616 | Heme signaling | 4.887516e-01 | 0.311 |
| R-HSA-186797 | Signaling by PDGF | 4.887516e-01 | 0.311 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.905529e-01 | 0.309 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.923984e-01 | 0.308 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.928176e-01 | 0.307 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.936389e-01 | 0.307 |
| R-HSA-373755 | Semaphorin interactions | 4.936389e-01 | 0.307 |
| R-HSA-877300 | Interferon gamma signaling | 5.056852e-01 | 0.296 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.173877e-01 | 0.286 |
| R-HSA-5218859 | Regulated Necrosis | 5.173877e-01 | 0.286 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.205258e-01 | 0.284 |
| R-HSA-448424 | Interleukin-17 signaling | 5.265744e-01 | 0.279 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.311023e-01 | 0.275 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.311023e-01 | 0.275 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.350960e-01 | 0.272 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.355873e-01 | 0.271 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.355873e-01 | 0.271 |
| R-HSA-2262752 | Cellular responses to stress | 5.380368e-01 | 0.269 |
| R-HSA-4086398 | Ca2+ pathway | 5.400296e-01 | 0.268 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.408015e-01 | 0.267 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.416599e-01 | 0.266 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.444297e-01 | 0.264 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.444297e-01 | 0.264 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.444297e-01 | 0.264 |
| R-HSA-8852135 | Protein ubiquitination | 5.487879e-01 | 0.261 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.487879e-01 | 0.261 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.493093e-01 | 0.260 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.493093e-01 | 0.260 |
| R-HSA-9658195 | Leishmania infection | 5.509992e-01 | 0.259 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.509992e-01 | 0.259 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.521208e-01 | 0.258 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.531048e-01 | 0.257 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.616158e-01 | 0.251 |
| R-HSA-216083 | Integrin cell surface interactions | 5.616158e-01 | 0.251 |
| R-HSA-168255 | Influenza Infection | 5.659939e-01 | 0.247 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.678216e-01 | 0.246 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.687808e-01 | 0.245 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.699657e-01 | 0.244 |
| R-HSA-9833482 | PKR-mediated signaling | 5.699657e-01 | 0.244 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.740812e-01 | 0.241 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.781576e-01 | 0.238 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.839844e-01 | 0.234 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.861944e-01 | 0.232 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.901856e-01 | 0.229 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.940791e-01 | 0.226 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.979653e-01 | 0.223 |
| R-HSA-156902 | Peptide chain elongation | 6.056271e-01 | 0.218 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.205183e-01 | 0.207 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.241529e-01 | 0.205 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.241529e-01 | 0.205 |
| R-HSA-72766 | Translation | 6.268047e-01 | 0.203 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.282652e-01 | 0.202 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.348507e-01 | 0.197 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.383489e-01 | 0.195 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.383489e-01 | 0.195 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.418138e-01 | 0.193 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.418138e-01 | 0.193 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.418138e-01 | 0.193 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.418138e-01 | 0.193 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.486451e-01 | 0.188 |
| R-HSA-422356 | Regulation of insulin secretion | 6.486451e-01 | 0.188 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.486451e-01 | 0.188 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.486451e-01 | 0.188 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.486451e-01 | 0.188 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.520120e-01 | 0.186 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.521021e-01 | 0.186 |
| R-HSA-109582 | Hemostasis | 6.541716e-01 | 0.184 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.586500e-01 | 0.181 |
| R-HSA-68882 | Mitotic Anaphase | 6.612934e-01 | 0.180 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.619217e-01 | 0.179 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.619217e-01 | 0.179 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.619217e-01 | 0.179 |
| R-HSA-1483255 | PI Metabolism | 6.619217e-01 | 0.179 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.635608e-01 | 0.178 |
| R-HSA-192823 | Viral mRNA Translation | 6.651622e-01 | 0.177 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.683719e-01 | 0.175 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.683719e-01 | 0.175 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.683719e-01 | 0.175 |
| R-HSA-9833110 | RSV-host interactions | 6.715509e-01 | 0.173 |
| R-HSA-6798695 | Neutrophil degranulation | 6.734949e-01 | 0.172 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.746997e-01 | 0.171 |
| R-HSA-5663205 | Infectious disease | 6.782099e-01 | 0.169 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.809076e-01 | 0.167 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.834250e-01 | 0.165 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.839673e-01 | 0.165 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.869978e-01 | 0.163 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.899995e-01 | 0.161 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.899995e-01 | 0.161 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.899995e-01 | 0.161 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.959172e-01 | 0.157 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.959172e-01 | 0.157 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.959172e-01 | 0.157 |
| R-HSA-72312 | rRNA processing | 6.961317e-01 | 0.157 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.988339e-01 | 0.156 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.045841e-01 | 0.152 |
| R-HSA-8939211 | ESR-mediated signaling | 7.063984e-01 | 0.151 |
| R-HSA-73894 | DNA Repair | 7.066463e-01 | 0.151 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.074182e-01 | 0.150 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.102252e-01 | 0.149 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.102252e-01 | 0.149 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.157593e-01 | 0.145 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.211883e-01 | 0.142 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.211883e-01 | 0.142 |
| R-HSA-68875 | Mitotic Prophase | 7.238641e-01 | 0.140 |
| R-HSA-73886 | Chromosome Maintenance | 7.265143e-01 | 0.139 |
| R-HSA-3371556 | Cellular response to heat stress | 7.265143e-01 | 0.139 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.265143e-01 | 0.139 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.291393e-01 | 0.137 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.291393e-01 | 0.137 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.317393e-01 | 0.136 |
| R-HSA-5688426 | Deubiquitination | 7.410016e-01 | 0.130 |
| R-HSA-114608 | Platelet degranulation | 7.443717e-01 | 0.128 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.552367e-01 | 0.122 |
| R-HSA-416476 | G alpha (q) signalling events | 7.569682e-01 | 0.121 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.587527e-01 | 0.120 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.610702e-01 | 0.119 |
| R-HSA-163685 | Integration of energy metabolism | 7.701208e-01 | 0.113 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.701208e-01 | 0.113 |
| R-HSA-388396 | GPCR downstream signalling | 7.765735e-01 | 0.110 |
| R-HSA-9664407 | Parasite infection | 7.788307e-01 | 0.109 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.788307e-01 | 0.109 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.788307e-01 | 0.109 |
| R-HSA-418594 | G alpha (i) signalling events | 7.791605e-01 | 0.108 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.809564e-01 | 0.107 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.817030e-01 | 0.107 |
| R-HSA-1643685 | Disease | 7.859527e-01 | 0.105 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.952789e-01 | 0.099 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.972476e-01 | 0.098 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.030413e-01 | 0.095 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.049358e-01 | 0.094 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.105113e-01 | 0.091 |
| R-HSA-9711097 | Cellular response to starvation | 8.159284e-01 | 0.088 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.263053e-01 | 0.083 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.287422e-01 | 0.082 |
| R-HSA-5619102 | SLC transporter disorders | 8.312736e-01 | 0.080 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.392424e-01 | 0.076 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.419972e-01 | 0.075 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.423242e-01 | 0.075 |
| R-HSA-372790 | Signaling by GPCR | 8.498694e-01 | 0.071 |
| R-HSA-1474244 | Extracellular matrix organization | 8.511978e-01 | 0.070 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.675476e-01 | 0.062 |
| R-HSA-168256 | Immune System | 8.677260e-01 | 0.062 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.713428e-01 | 0.060 |
| R-HSA-9609690 | HCMV Early Events | 8.738127e-01 | 0.059 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.786122e-01 | 0.056 |
| R-HSA-428157 | Sphingolipid metabolism | 8.797834e-01 | 0.056 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.809434e-01 | 0.055 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.820923e-01 | 0.054 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.833392e-01 | 0.054 |
| R-HSA-72172 | mRNA Splicing | 8.843571e-01 | 0.053 |
| R-HSA-8951664 | Neddylation | 9.019432e-01 | 0.045 |
| R-HSA-15869 | Metabolism of nucleotides | 9.152381e-01 | 0.038 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.238342e-01 | 0.034 |
| R-HSA-9609646 | HCMV Infection | 9.260244e-01 | 0.033 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.270271e-01 | 0.033 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.379117e-01 | 0.028 |
| R-HSA-112316 | Neuronal System | 9.495708e-01 | 0.022 |
| R-HSA-1483257 | Phospholipid metabolism | 9.522767e-01 | 0.021 |
| R-HSA-8957322 | Metabolism of steroids | 9.640444e-01 | 0.016 |
| R-HSA-168249 | Innate Immune System | 9.772338e-01 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.813443e-01 | 0.008 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.820625e-01 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.825831e-01 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.855787e-01 | 0.006 |
| R-HSA-449147 | Signaling by Interleukins | 9.864173e-01 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 9.970154e-01 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 9.973628e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.973865e-01 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 9.991276e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.994335e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.857 | 0.233 | 2 | 0.841 |
CLK3 |
0.851 | 0.227 | 1 | 0.877 |
MOS |
0.847 | 0.244 | 1 | 0.889 |
KIS |
0.845 | 0.226 | 1 | 0.770 |
BMPR1B |
0.845 | 0.306 | 1 | 0.829 |
CDC7 |
0.842 | 0.079 | 1 | 0.864 |
GRK1 |
0.842 | 0.195 | -2 | 0.806 |
DSTYK |
0.838 | 0.145 | 2 | 0.852 |
IKKB |
0.838 | 0.049 | -2 | 0.750 |
GRK7 |
0.837 | 0.245 | 1 | 0.754 |
GRK6 |
0.837 | 0.195 | 1 | 0.825 |
IKKA |
0.835 | 0.141 | -2 | 0.724 |
FAM20C |
0.834 | 0.170 | 2 | 0.599 |
BMPR1A |
0.834 | 0.293 | 1 | 0.813 |
GRK5 |
0.833 | 0.084 | -3 | 0.885 |
ACVR2B |
0.832 | 0.254 | -2 | 0.877 |
CAMK2G |
0.832 | 0.053 | 2 | 0.788 |
RAF1 |
0.832 | 0.029 | 1 | 0.810 |
PIM3 |
0.831 | 0.027 | -3 | 0.816 |
BMPR2 |
0.830 | 0.040 | -2 | 0.903 |
GCN2 |
0.830 | -0.034 | 2 | 0.776 |
GRK4 |
0.830 | 0.134 | -2 | 0.850 |
CK2A2 |
0.830 | 0.309 | 1 | 0.782 |
TGFBR1 |
0.830 | 0.201 | -2 | 0.869 |
ACVR2A |
0.829 | 0.220 | -2 | 0.872 |
NDR2 |
0.829 | 0.021 | -3 | 0.818 |
MTOR |
0.829 | -0.054 | 1 | 0.787 |
PRPK |
0.829 | -0.134 | -1 | 0.694 |
NEK6 |
0.829 | 0.082 | -2 | 0.875 |
CAMK1B |
0.828 | 0.027 | -3 | 0.837 |
NLK |
0.827 | 0.054 | 1 | 0.872 |
ATR |
0.826 | -0.014 | 1 | 0.781 |
PDHK4 |
0.825 | -0.140 | 1 | 0.826 |
NEK7 |
0.824 | 0.009 | -3 | 0.824 |
ALK2 |
0.824 | 0.213 | -2 | 0.878 |
ALK4 |
0.824 | 0.149 | -2 | 0.887 |
TGFBR2 |
0.823 | 0.020 | -2 | 0.886 |
LATS1 |
0.823 | 0.155 | -3 | 0.827 |
ATM |
0.822 | 0.065 | 1 | 0.716 |
PLK1 |
0.822 | 0.139 | -2 | 0.868 |
CDK1 |
0.822 | 0.175 | 1 | 0.751 |
IKKE |
0.821 | -0.052 | 1 | 0.681 |
PIM1 |
0.820 | 0.035 | -3 | 0.755 |
MLK1 |
0.820 | -0.023 | 2 | 0.787 |
TBK1 |
0.819 | -0.095 | 1 | 0.684 |
RSK2 |
0.819 | 0.032 | -3 | 0.738 |
ERK5 |
0.819 | -0.015 | 1 | 0.790 |
CDKL1 |
0.819 | -0.025 | -3 | 0.784 |
PKN3 |
0.819 | -0.020 | -3 | 0.796 |
PDHK1 |
0.818 | -0.101 | 1 | 0.795 |
SRPK1 |
0.818 | 0.038 | -3 | 0.731 |
HIPK4 |
0.818 | 0.051 | 1 | 0.845 |
CAMLCK |
0.817 | -0.005 | -2 | 0.892 |
NIK |
0.817 | -0.092 | -3 | 0.856 |
ULK2 |
0.817 | -0.144 | 2 | 0.759 |
SKMLCK |
0.817 | -0.008 | -2 | 0.881 |
DAPK2 |
0.816 | -0.002 | -3 | 0.836 |
GRK2 |
0.816 | 0.085 | -2 | 0.741 |
ANKRD3 |
0.816 | 0.068 | 1 | 0.801 |
CAMK2B |
0.816 | 0.075 | 2 | 0.759 |
CDK8 |
0.816 | 0.107 | 1 | 0.760 |
CK2A1 |
0.815 | 0.258 | 1 | 0.764 |
NDR1 |
0.815 | -0.046 | -3 | 0.798 |
BCKDK |
0.815 | -0.076 | -1 | 0.703 |
MST4 |
0.815 | -0.040 | 2 | 0.834 |
PLK3 |
0.814 | 0.113 | 2 | 0.725 |
DLK |
0.814 | -0.050 | 1 | 0.794 |
NUAK2 |
0.813 | -0.049 | -3 | 0.809 |
LATS2 |
0.813 | -0.026 | -5 | 0.667 |
PRKD1 |
0.813 | -0.019 | -3 | 0.756 |
P70S6KB |
0.812 | 0.003 | -3 | 0.762 |
PKN2 |
0.812 | -0.037 | -3 | 0.803 |
ICK |
0.812 | 0.009 | -3 | 0.801 |
HUNK |
0.811 | -0.107 | 2 | 0.760 |
CHAK2 |
0.811 | -0.086 | -1 | 0.669 |
AURC |
0.811 | 0.067 | -2 | 0.767 |
PRKX |
0.811 | 0.118 | -3 | 0.651 |
JNK3 |
0.811 | 0.152 | 1 | 0.750 |
SRPK2 |
0.811 | 0.032 | -3 | 0.655 |
CAMK2A |
0.811 | 0.059 | 2 | 0.772 |
TLK2 |
0.811 | 0.075 | 1 | 0.757 |
PRKD2 |
0.810 | -0.002 | -3 | 0.712 |
PKCD |
0.810 | -0.015 | 2 | 0.763 |
ULK1 |
0.810 | -0.116 | -3 | 0.783 |
GRK3 |
0.810 | 0.097 | -2 | 0.703 |
AURA |
0.810 | 0.095 | -2 | 0.732 |
MLK3 |
0.810 | 0.013 | 2 | 0.715 |
MARK4 |
0.809 | -0.070 | 4 | 0.855 |
SRPK3 |
0.809 | 0.017 | -3 | 0.729 |
PKACG |
0.809 | 0.004 | -2 | 0.840 |
CDK19 |
0.808 | 0.095 | 1 | 0.728 |
CLK2 |
0.808 | 0.115 | -3 | 0.727 |
CLK4 |
0.808 | 0.074 | -3 | 0.741 |
DYRK2 |
0.808 | 0.093 | 1 | 0.779 |
RIPK3 |
0.808 | -0.154 | 3 | 0.681 |
MLK4 |
0.808 | 0.032 | 2 | 0.697 |
RSK3 |
0.807 | -0.028 | -3 | 0.741 |
P90RSK |
0.807 | -0.037 | -3 | 0.738 |
AMPKA1 |
0.807 | -0.071 | -3 | 0.808 |
JNK2 |
0.807 | 0.138 | 1 | 0.724 |
CDK5 |
0.807 | 0.108 | 1 | 0.793 |
PKACB |
0.806 | 0.074 | -2 | 0.790 |
PKR |
0.805 | -0.049 | 1 | 0.809 |
CDKL5 |
0.805 | -0.048 | -3 | 0.757 |
MEK1 |
0.805 | -0.082 | 2 | 0.805 |
MAPKAPK2 |
0.805 | 0.003 | -3 | 0.675 |
P38G |
0.805 | 0.139 | 1 | 0.666 |
PINK1 |
0.805 | 0.013 | 1 | 0.859 |
YSK4 |
0.805 | -0.021 | 1 | 0.731 |
BRAF |
0.805 | 0.090 | -4 | 0.784 |
PLK2 |
0.804 | 0.186 | -3 | 0.888 |
RSK4 |
0.804 | 0.027 | -3 | 0.717 |
WNK1 |
0.804 | -0.166 | -2 | 0.851 |
TLK1 |
0.804 | 0.111 | -2 | 0.880 |
CDK2 |
0.804 | 0.085 | 1 | 0.803 |
CAMK2D |
0.804 | -0.091 | -3 | 0.781 |
TSSK2 |
0.803 | -0.064 | -5 | 0.683 |
NEK9 |
0.803 | -0.179 | 2 | 0.817 |
CAMK4 |
0.803 | -0.068 | -3 | 0.780 |
MSK2 |
0.802 | -0.012 | -3 | 0.711 |
CDK3 |
0.802 | 0.133 | 1 | 0.693 |
CDK18 |
0.802 | 0.099 | 1 | 0.716 |
TTBK2 |
0.802 | -0.146 | 2 | 0.669 |
HIPK2 |
0.802 | 0.118 | 1 | 0.721 |
ERK1 |
0.801 | 0.106 | 1 | 0.704 |
P38B |
0.801 | 0.117 | 1 | 0.705 |
MASTL |
0.801 | -0.299 | -2 | 0.812 |
AURB |
0.801 | 0.039 | -2 | 0.763 |
CDK13 |
0.801 | 0.066 | 1 | 0.753 |
P38D |
0.800 | 0.155 | 1 | 0.673 |
WNK3 |
0.800 | -0.273 | 1 | 0.770 |
CK1D |
0.800 | 0.069 | -3 | 0.575 |
MSK1 |
0.800 | 0.031 | -3 | 0.711 |
CDK7 |
0.800 | 0.045 | 1 | 0.779 |
CDK17 |
0.800 | 0.108 | 1 | 0.676 |
P38A |
0.800 | 0.082 | 1 | 0.770 |
TSSK1 |
0.800 | -0.059 | -3 | 0.824 |
MEKK3 |
0.800 | -0.019 | 1 | 0.755 |
CK1E |
0.800 | 0.030 | -3 | 0.630 |
PAK1 |
0.800 | -0.027 | -2 | 0.829 |
PRP4 |
0.799 | 0.056 | -3 | 0.729 |
PASK |
0.799 | 0.050 | -3 | 0.843 |
ERK2 |
0.799 | 0.088 | 1 | 0.749 |
MAPKAPK3 |
0.799 | -0.096 | -3 | 0.708 |
AMPKA2 |
0.799 | -0.077 | -3 | 0.775 |
CLK1 |
0.799 | 0.051 | -3 | 0.710 |
MLK2 |
0.799 | -0.188 | 2 | 0.795 |
HIPK1 |
0.798 | 0.085 | 1 | 0.794 |
MYLK4 |
0.798 | -0.008 | -2 | 0.849 |
QSK |
0.797 | -0.045 | 4 | 0.845 |
RIPK1 |
0.796 | -0.248 | 1 | 0.766 |
NUAK1 |
0.796 | -0.072 | -3 | 0.753 |
VRK2 |
0.796 | -0.249 | 1 | 0.836 |
PRKD3 |
0.795 | -0.043 | -3 | 0.710 |
AKT2 |
0.795 | 0.018 | -3 | 0.662 |
CK1A2 |
0.795 | 0.050 | -3 | 0.577 |
PERK |
0.795 | -0.083 | -2 | 0.884 |
DRAK1 |
0.795 | -0.049 | 1 | 0.773 |
IRE2 |
0.795 | -0.102 | 2 | 0.734 |
IRE1 |
0.794 | -0.175 | 1 | 0.757 |
DNAPK |
0.794 | -0.045 | 1 | 0.652 |
GSK3A |
0.794 | 0.058 | 4 | 0.414 |
PKCB |
0.794 | -0.070 | 2 | 0.717 |
PKCG |
0.794 | -0.076 | 2 | 0.704 |
SIK |
0.794 | -0.057 | -3 | 0.733 |
CDK12 |
0.793 | 0.063 | 1 | 0.727 |
NIM1 |
0.793 | -0.175 | 3 | 0.727 |
MARK2 |
0.793 | -0.038 | 4 | 0.770 |
MEKK2 |
0.793 | -0.036 | 2 | 0.777 |
JNK1 |
0.792 | 0.129 | 1 | 0.724 |
MEKK1 |
0.792 | -0.075 | 1 | 0.753 |
PIM2 |
0.792 | -0.020 | -3 | 0.708 |
CHK1 |
0.792 | -0.058 | -3 | 0.769 |
GAK |
0.792 | 0.044 | 1 | 0.833 |
PAK3 |
0.792 | -0.090 | -2 | 0.829 |
PKG2 |
0.792 | 0.015 | -2 | 0.792 |
TAO3 |
0.792 | -0.014 | 1 | 0.760 |
HRI |
0.792 | -0.107 | -2 | 0.892 |
PAK2 |
0.791 | -0.060 | -2 | 0.818 |
PKCA |
0.791 | -0.072 | 2 | 0.706 |
PAK6 |
0.791 | 0.010 | -2 | 0.764 |
MARK3 |
0.791 | -0.044 | 4 | 0.801 |
ZAK |
0.791 | -0.077 | 1 | 0.727 |
QIK |
0.790 | -0.166 | -3 | 0.793 |
NEK2 |
0.790 | -0.159 | 2 | 0.796 |
SMG1 |
0.790 | -0.142 | 1 | 0.725 |
DYRK4 |
0.790 | 0.100 | 1 | 0.730 |
SGK3 |
0.790 | -0.018 | -3 | 0.718 |
PKCH |
0.790 | -0.090 | 2 | 0.697 |
CDK14 |
0.789 | 0.079 | 1 | 0.754 |
CDK16 |
0.789 | 0.099 | 1 | 0.689 |
DYRK1B |
0.789 | 0.079 | 1 | 0.755 |
DYRK1A |
0.789 | 0.042 | 1 | 0.810 |
MST2 |
0.789 | 0.095 | 1 | 0.761 |
SMMLCK |
0.788 | -0.013 | -3 | 0.786 |
MEK5 |
0.788 | -0.213 | 2 | 0.793 |
MELK |
0.787 | -0.134 | -3 | 0.746 |
DAPK3 |
0.787 | 0.038 | -3 | 0.772 |
CAMK1G |
0.787 | -0.060 | -3 | 0.728 |
PKACA |
0.787 | 0.048 | -2 | 0.753 |
BRSK1 |
0.787 | -0.089 | -3 | 0.756 |
MNK2 |
0.786 | -0.088 | -2 | 0.844 |
MST3 |
0.786 | -0.074 | 2 | 0.806 |
PKCZ |
0.786 | -0.131 | 2 | 0.757 |
CHAK1 |
0.785 | -0.214 | 2 | 0.744 |
NEK8 |
0.785 | -0.061 | 2 | 0.791 |
TAK1 |
0.785 | 0.034 | 1 | 0.798 |
CK1G1 |
0.785 | -0.013 | -3 | 0.649 |
MARK1 |
0.785 | -0.076 | 4 | 0.820 |
PHKG1 |
0.785 | -0.145 | -3 | 0.780 |
DYRK3 |
0.784 | 0.063 | 1 | 0.788 |
HIPK3 |
0.784 | 0.035 | 1 | 0.772 |
NEK5 |
0.784 | -0.153 | 1 | 0.772 |
CDK9 |
0.784 | 0.019 | 1 | 0.753 |
PLK4 |
0.784 | -0.150 | 2 | 0.589 |
MNK1 |
0.783 | -0.083 | -2 | 0.859 |
DAPK1 |
0.783 | 0.037 | -3 | 0.762 |
GSK3B |
0.783 | -0.029 | 4 | 0.404 |
AKT1 |
0.781 | 0.011 | -3 | 0.667 |
DCAMKL1 |
0.781 | -0.097 | -3 | 0.746 |
CDK10 |
0.781 | 0.068 | 1 | 0.746 |
GCK |
0.780 | -0.038 | 1 | 0.783 |
CAMKK1 |
0.779 | -0.149 | -2 | 0.752 |
P70S6K |
0.778 | -0.062 | -3 | 0.668 |
CAMK1D |
0.777 | -0.026 | -3 | 0.638 |
MPSK1 |
0.777 | -0.094 | 1 | 0.787 |
MAPKAPK5 |
0.776 | -0.159 | -3 | 0.662 |
TAO2 |
0.775 | -0.144 | 2 | 0.823 |
ERK7 |
0.775 | 0.013 | 2 | 0.546 |
SNRK |
0.775 | -0.233 | 2 | 0.650 |
SSTK |
0.775 | -0.093 | 4 | 0.818 |
DCAMKL2 |
0.774 | -0.103 | -3 | 0.764 |
TTK |
0.774 | 0.096 | -2 | 0.885 |
TNIK |
0.774 | -0.062 | 3 | 0.784 |
CAMKK2 |
0.774 | -0.147 | -2 | 0.753 |
NEK11 |
0.773 | -0.227 | 1 | 0.758 |
PDK1 |
0.773 | -0.138 | 1 | 0.751 |
EEF2K |
0.773 | -0.061 | 3 | 0.764 |
MINK |
0.773 | -0.094 | 1 | 0.745 |
OSR1 |
0.773 | 0.069 | 2 | 0.773 |
SGK1 |
0.773 | 0.019 | -3 | 0.576 |
CDK6 |
0.773 | 0.062 | 1 | 0.732 |
PKCT |
0.772 | -0.110 | 2 | 0.708 |
WNK4 |
0.772 | -0.261 | -2 | 0.823 |
BRSK2 |
0.772 | -0.192 | -3 | 0.759 |
SLK |
0.772 | -0.068 | -2 | 0.749 |
MST1 |
0.771 | -0.038 | 1 | 0.739 |
LKB1 |
0.771 | -0.180 | -3 | 0.783 |
TTBK1 |
0.771 | -0.185 | 2 | 0.581 |
IRAK4 |
0.770 | -0.248 | 1 | 0.739 |
AKT3 |
0.770 | 0.016 | -3 | 0.590 |
PAK5 |
0.770 | -0.036 | -2 | 0.715 |
PKCE |
0.769 | -0.058 | 2 | 0.692 |
HGK |
0.769 | -0.120 | 3 | 0.779 |
PKCI |
0.768 | -0.110 | 2 | 0.725 |
HPK1 |
0.768 | -0.107 | 1 | 0.760 |
MAK |
0.768 | 0.047 | -2 | 0.693 |
ALPHAK3 |
0.768 | 0.071 | -1 | 0.686 |
MRCKA |
0.768 | -0.014 | -3 | 0.712 |
PAK4 |
0.767 | -0.016 | -2 | 0.723 |
BMPR2_TYR |
0.767 | 0.237 | -1 | 0.783 |
CDK4 |
0.767 | 0.052 | 1 | 0.719 |
MRCKB |
0.766 | -0.018 | -3 | 0.702 |
ROCK2 |
0.766 | -0.020 | -3 | 0.740 |
PDHK3_TYR |
0.766 | 0.200 | 4 | 0.888 |
IRAK1 |
0.766 | -0.300 | -1 | 0.592 |
PHKG2 |
0.766 | -0.145 | -3 | 0.761 |
LOK |
0.765 | -0.129 | -2 | 0.808 |
LRRK2 |
0.765 | -0.226 | 2 | 0.819 |
MAP2K6_TYR |
0.765 | 0.229 | -1 | 0.753 |
CK1A |
0.764 | 0.041 | -3 | 0.500 |
KHS2 |
0.764 | -0.064 | 1 | 0.763 |
CAMK1A |
0.764 | -0.027 | -3 | 0.623 |
DMPK1 |
0.763 | 0.019 | -3 | 0.730 |
NEK4 |
0.763 | -0.239 | 1 | 0.735 |
CHK2 |
0.762 | -0.057 | -3 | 0.595 |
PDHK4_TYR |
0.762 | 0.157 | 2 | 0.841 |
PDHK1_TYR |
0.762 | 0.188 | -1 | 0.769 |
BUB1 |
0.762 | -0.017 | -5 | 0.664 |
VRK1 |
0.761 | -0.248 | 2 | 0.805 |
SBK |
0.760 | -0.007 | -3 | 0.532 |
MAP2K4_TYR |
0.760 | 0.145 | -1 | 0.739 |
MAP3K15 |
0.760 | -0.253 | 1 | 0.710 |
PBK |
0.759 | -0.077 | 1 | 0.745 |
MEK2 |
0.759 | -0.242 | 2 | 0.785 |
KHS1 |
0.759 | -0.120 | 1 | 0.736 |
NEK1 |
0.758 | -0.245 | 1 | 0.741 |
PKN1 |
0.757 | -0.091 | -3 | 0.673 |
YSK1 |
0.756 | -0.160 | 2 | 0.792 |
MOK |
0.756 | -0.011 | 1 | 0.774 |
MEKK6 |
0.756 | -0.298 | 1 | 0.737 |
HASPIN |
0.754 | -0.058 | -1 | 0.550 |
RIPK2 |
0.754 | -0.252 | 1 | 0.677 |
TESK1_TYR |
0.752 | -0.084 | 3 | 0.831 |
EPHA6 |
0.752 | 0.133 | -1 | 0.796 |
MYO3A |
0.752 | -0.066 | 1 | 0.751 |
STK33 |
0.752 | -0.219 | 2 | 0.560 |
YANK3 |
0.752 | -0.057 | 2 | 0.351 |
ROCK1 |
0.752 | -0.028 | -3 | 0.707 |
CK1G3 |
0.751 | 0.054 | -3 | 0.464 |
MAP2K7_TYR |
0.750 | -0.133 | 2 | 0.822 |
CRIK |
0.750 | -0.031 | -3 | 0.657 |
PKG1 |
0.750 | -0.020 | -2 | 0.732 |
BIKE |
0.749 | -0.037 | 1 | 0.717 |
PINK1_TYR |
0.748 | -0.123 | 1 | 0.812 |
EPHB4 |
0.746 | 0.094 | -1 | 0.766 |
PKMYT1_TYR |
0.746 | -0.181 | 3 | 0.805 |
MYO3B |
0.745 | -0.129 | 2 | 0.807 |
INSRR |
0.744 | 0.109 | 3 | 0.692 |
PTK2 |
0.744 | 0.219 | -1 | 0.814 |
TXK |
0.744 | 0.076 | 1 | 0.823 |
SYK |
0.744 | 0.211 | -1 | 0.769 |
FER |
0.743 | -0.003 | 1 | 0.816 |
EPHA4 |
0.743 | 0.079 | 2 | 0.717 |
FLT1 |
0.743 | 0.174 | -1 | 0.824 |
NEK3 |
0.741 | -0.264 | 1 | 0.690 |
RET |
0.741 | -0.067 | 1 | 0.739 |
STLK3 |
0.741 | -0.123 | 1 | 0.688 |
ASK1 |
0.740 | -0.230 | 1 | 0.700 |
JAK3 |
0.740 | 0.074 | 1 | 0.724 |
EPHB2 |
0.739 | 0.108 | -1 | 0.761 |
FGR |
0.739 | -0.034 | 1 | 0.788 |
YES1 |
0.738 | -0.024 | -1 | 0.667 |
ABL2 |
0.738 | -0.033 | -1 | 0.676 |
EPHB1 |
0.738 | 0.067 | 1 | 0.777 |
LCK |
0.737 | 0.022 | -1 | 0.684 |
CK1G2 |
0.737 | 0.048 | -3 | 0.565 |
LIMK2_TYR |
0.737 | -0.171 | -3 | 0.833 |
BLK |
0.737 | 0.051 | -1 | 0.691 |
TAO1 |
0.737 | -0.182 | 1 | 0.674 |
MST1R |
0.736 | -0.109 | 3 | 0.758 |
LIMK1_TYR |
0.736 | -0.224 | 2 | 0.826 |
TYK2 |
0.735 | -0.156 | 1 | 0.730 |
FGFR2 |
0.735 | 0.030 | 3 | 0.750 |
FYN |
0.735 | 0.059 | -1 | 0.667 |
CSF1R |
0.734 | -0.071 | 3 | 0.725 |
SRMS |
0.734 | -0.037 | 1 | 0.802 |
KIT |
0.734 | -0.018 | 3 | 0.735 |
JAK2 |
0.734 | -0.116 | 1 | 0.726 |
HCK |
0.734 | -0.052 | -1 | 0.675 |
KDR |
0.734 | 0.017 | 3 | 0.689 |
EPHB3 |
0.732 | 0.010 | -1 | 0.747 |
ABL1 |
0.732 | -0.068 | -1 | 0.662 |
MET |
0.732 | 0.005 | 3 | 0.734 |
ROS1 |
0.732 | -0.144 | 3 | 0.698 |
FLT3 |
0.731 | -0.057 | 3 | 0.719 |
TYRO3 |
0.730 | -0.197 | 3 | 0.732 |
EGFR |
0.730 | 0.063 | 1 | 0.612 |
FGFR3 |
0.730 | 0.044 | 3 | 0.724 |
DDR1 |
0.729 | -0.160 | 4 | 0.793 |
AAK1 |
0.728 | -0.017 | 1 | 0.621 |
EPHA5 |
0.728 | 0.094 | 2 | 0.701 |
PDGFRB |
0.728 | -0.088 | 3 | 0.742 |
EPHA7 |
0.727 | 0.012 | 2 | 0.722 |
ERBB2 |
0.727 | -0.042 | 1 | 0.710 |
EPHA3 |
0.727 | 0.009 | 2 | 0.693 |
NTRK1 |
0.727 | -0.023 | -1 | 0.739 |
FGFR1 |
0.726 | -0.034 | 3 | 0.719 |
TEC |
0.725 | -0.075 | -1 | 0.570 |
FGFR4 |
0.725 | 0.049 | -1 | 0.713 |
ITK |
0.724 | -0.109 | -1 | 0.648 |
BMX |
0.724 | -0.077 | -1 | 0.581 |
FLT4 |
0.723 | -0.008 | 3 | 0.686 |
LYN |
0.723 | -0.040 | 3 | 0.664 |
INSR |
0.723 | -0.002 | 3 | 0.672 |
EPHA8 |
0.723 | 0.015 | -1 | 0.735 |
MATK |
0.722 | -0.054 | -1 | 0.630 |
PTK6 |
0.722 | -0.155 | -1 | 0.583 |
ALK |
0.722 | -0.078 | 3 | 0.678 |
WEE1_TYR |
0.721 | -0.123 | -1 | 0.590 |
NTRK3 |
0.721 | -0.037 | -1 | 0.695 |
SRC |
0.720 | -0.029 | -1 | 0.654 |
MERTK |
0.720 | -0.139 | 3 | 0.711 |
TEK |
0.719 | -0.177 | 3 | 0.675 |
NTRK2 |
0.719 | -0.061 | 3 | 0.698 |
YANK2 |
0.719 | -0.078 | 2 | 0.367 |
JAK1 |
0.719 | -0.138 | 1 | 0.675 |
EPHA2 |
0.719 | 0.075 | -1 | 0.753 |
LTK |
0.719 | -0.105 | 3 | 0.699 |
FRK |
0.718 | -0.084 | -1 | 0.691 |
NEK10_TYR |
0.718 | -0.188 | 1 | 0.643 |
TNK2 |
0.717 | -0.200 | 3 | 0.718 |
BTK |
0.717 | -0.215 | -1 | 0.586 |
TNNI3K_TYR |
0.717 | -0.134 | 1 | 0.729 |
ERBB4 |
0.715 | 0.031 | 1 | 0.646 |
PDGFRA |
0.715 | -0.198 | 3 | 0.735 |
PTK2B |
0.714 | -0.078 | -1 | 0.608 |
IGF1R |
0.714 | 0.019 | 3 | 0.623 |
AXL |
0.712 | -0.236 | 3 | 0.721 |
ZAP70 |
0.711 | 0.043 | -1 | 0.662 |
TNK1 |
0.710 | -0.253 | 3 | 0.710 |
DDR2 |
0.709 | -0.047 | 3 | 0.702 |
CSK |
0.709 | -0.117 | 2 | 0.729 |
EPHA1 |
0.707 | -0.193 | 3 | 0.704 |
FES |
0.695 | -0.099 | -1 | 0.567 |
MUSK |
0.695 | -0.166 | 1 | 0.594 |