Motif 569 (n=176)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S383 | ochoa | Golgin A8 family member Q | None |
| A2VDJ0 | TMEM131L | S1276 | ochoa | Transmembrane protein 131-like | [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}. |
| H0YC42 | None | S72 | ochoa | Tumor protein D52 | None |
| H3BSY2 | GOLGA8M | S383 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S382 | ochoa | Golgin subfamily A member 8R | None |
| O14646 | CHD1 | S1040 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14791 | APOL1 | S311 | ochoa|psp | Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) | May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. |
| O15061 | SYNM | S754 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15355 | PPM1G | S201 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43491 | EPB41L2 | S170 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43719 | HTATSF1 | S467 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43765 | SGTA | S88 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| O43837 | IDH3B | S173 | ochoa | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}. |
| O60437 | PPL | S1331 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O75154 | RAB11FIP3 | S451 | psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O75475 | PSIP1 | S434 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75791 | GRAP2 | S41 | ochoa | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| O75844 | ZMPSTE24 | S310 | ochoa | CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33293369, PubMed:33315887). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33293369, PubMed:33315887). Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28169297, PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811). {ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:28246125, ECO:0000269|PubMed:33293369, ECO:0000269|PubMed:33315887, ECO:0000269|PubMed:35283811}. |
| O94885 | SASH1 | S285 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| P10451 | SPP1 | S239 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11142 | HSPA8 | S511 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12882 | MYH1 | S1132 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1611 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S851 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1469 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1607 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1471 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1609 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13639 | EEF2 | S584 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P16157 | ANK1 | S1617 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17931 | LGALS3 | S188 | ochoa | Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076, ECO:0000269|PubMed:27693506}. |
| P23327 | HRC | S170 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P23327 | HRC | S431 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P24593 | IGFBP5 | S116 | ochoa|psp | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}. |
| P24821 | TNC | S72 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P24821 | TNC | S616 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P25054 | APC | S246 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27797 | CALR | S195 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P30307 | CDC25C | S191 | psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P31327 | CPS1 | S1021 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31947 | SFN | S69 | psp | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P31947 | SFN | S74 | ochoa|psp | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P35579 | MYH9 | S1126 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | S1013 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35659 | DEK | S232 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P42224 | STAT1 | S162 | ochoa | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}. |
| P42261 | GRIA1 | S567 | psp | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| P43243 | MATR3 | S631 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46821 | MAP1B | S1156 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S2024 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S564 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S1128 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S229 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49792 | RANBP2 | S2925 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50502 | ST13 | S76 | ochoa|psp | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P51608 | MECP2 | S313 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P52566 | ARHGDIB | S20 | ochoa|psp | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P54132 | BLM | S1196 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P98175 | RBM10 | S50 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| P98175 | RBM10 | S738 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q02410 | APBA1 | S248 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q02952 | AKAP12 | S841 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03001 | DST | S2491 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q05209 | PTPN12 | S704 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08945 | SSRP1 | S673 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09028 | RBBP4 | S355 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q12888 | TP53BP1 | S860 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1202 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12906 | ILF3 | S56 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12906 | ILF3 | S73 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13043 | STK4 | S320 | ochoa|psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13098 | GPS1 | S240 | ochoa | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q13177 | PAK2 | S64 | ochoa|psp | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13501 | SQSTM1 | S355 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13796 | SHROOM2 | S1425 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14562 | DHX8 | S385 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14680 | MELK | S407 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14690 | PDCD11 | S1454 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14839 | CHD4 | S1576 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q14978 | NOLC1 | S432 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14980 | NUMA1 | S934 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15424 | SAFB | S209 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16543 | CDC37 | S140 | ochoa | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16576 | RBBP7 | S354 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16666 | IFI16 | S568 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q52LW3 | ARHGAP29 | S176 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5JTZ5 | C9orf152 | S87 | ochoa | Uncharacterized protein C9orf152 | None |
| Q5T4S7 | UBR4 | S1634 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5VTR2 | RNF20 | S136 | ochoa | E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| Q5VV52 | ZNF691 | S77 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5VV67 | PPRC1 | S415 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q658Y4 | FAM91A1 | S340 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6IQ55 | TTBK2 | S781 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NTE8 | MRNIP | S115 | psp | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
| Q6P0Q8 | MAST2 | S1503 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P444 | MTFR2 | S328 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
| Q6PJF5 | RHBDF2 | S166 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6WKZ4 | RAB11FIP1 | S686 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q71F23 | CENPU | S158 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z3K6 | MIER3 | S165 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z4S6 | KIF21A | S710 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z7L8 | C11orf96 | S385 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86TV6 | TTC7B | S657 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86VM9 | ZC3H18 | S179 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IW35 | CEP97 | S724 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IY42 | C4orf19 | S216 | ochoa | PDCD10 and GCKIII kinases-associated protein 1 | Acts as a tumor suppressor (PubMed:36882524, PubMed:38517886). Acts as a tumor suppressor for colorectal cancer cell proliferation by targeting KEAP1/USP17/ELK1/CDK6 axis (PubMed:36882524). {ECO:0000269|PubMed:36882524, ECO:0000269|PubMed:38517886}. |
| Q8IZP2 | ST13P4 | S72 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8IZT6 | ASPM | S211 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N108 | MIER1 | S166 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N128 | FAM177A1 | S70 | ochoa | Protein FAM177A1 | None |
| Q8N3K9 | CMYA5 | S3307 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3S3 | PHTF2 | S336 | ochoa | Protein PHTF2 | None |
| Q8N5C6 | SRBD1 | S151 | ochoa | S1 RNA-binding domain-containing protein 1 | None |
| Q8N5P1 | ZC3H8 | S83 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8NFC6 | BOD1L1 | S545 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHP6 | MOSPD2 | S267 | ochoa | Motile sperm domain-containing protein 2 | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}. |
| Q8TC05 | MDM1 | S263 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q92547 | TOPBP1 | S747 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92574 | TSC1 | S472 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92974 | ARHGEF2 | S932 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q969Z0 | TBRG4 | S64 | ochoa | FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) | Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}. |
| Q96CT7 | CCDC124 | S141 | ochoa | Coiled-coil domain-containing protein 124 | Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}. |
| Q96FF9 | CDCA5 | S126 | ochoa|psp | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96IZ7 | RSRC1 | S239 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96JM3 | CHAMP1 | S633 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96N64 | PWWP2A | S534 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96PY6 | NEK1 | S874 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RL1 | UIMC1 | S343 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RU3 | FNBP1 | S527 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q96SD1 | DCLRE1C | S655 | psp | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q96T23 | RSF1 | S229 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99460 | PSMD1 | S296 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9BPX3 | NCAPG | S680 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BQE9 | BCL7B | S148 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BVI0 | PHF20 | S225 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BWH6 | RPAP1 | S277 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BXP5 | SRRT | S570 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BY89 | KIAA1671 | S1675 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0C2 | TNKS1BP1 | S237 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0E3 | SAP130 | S855 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H0M4 | ZCWPW1 | S610 | ochoa | Zinc finger CW-type PWWP domain protein 1 | Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:20826339, PubMed:32744506). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity). {ECO:0000250|UniProtKB:Q6IR42, ECO:0000269|PubMed:20826339, ECO:0000269|PubMed:32744506}. |
| Q9H1P3 | OSBPL2 | S52 | ochoa | Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2) | Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}. |
| Q9H2Y7 | ZNF106 | S1031 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H6T3 | RPAP3 | S116 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H6T3 | RPAP3 | S121 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H7Z3 | NRDE2 | S210 | ochoa | Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) | Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. |
| Q9HB71 | CACYBP | S180 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HBF4 | ZFYVE1 | S129 | ochoa | Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) | Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:30970241, PubMed:31293035). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11256955, PubMed:11739631). {ECO:0000269|PubMed:11256955, ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication. {ECO:0000269|PubMed:35551511}. |
| Q9NR30 | DDX21 | S121 | ochoa|psp | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR30 | DDX21 | S168 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR45 | NANS | S253 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NYI0 | PSD3 | S562 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NYL2 | MAP3K20 | S754 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P2W9 | STX18 | S283 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UBC2 | EPS15L1 | S402 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBC2 | EPS15L1 | S434 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UHB6 | LIMA1 | S671 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UIG0 | BAZ1B | S167 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKX2 | MYH2 | S1134 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1613 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD2 | MTUS1 | S1083 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULI0 | ATAD2B | S1314 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UN19 | DAPP1 | S137 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9Y2K1 | ZBTB1 | S313 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y343 | SNX24 | S122 | ochoa | Sorting nexin-24 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
| Q9Y485 | DMXL1 | S421 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4B5 | MTCL1 | S778 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y623 | MYH4 | S1132 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P19338 | NCL | S532 | Sugiyama | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| Q13601 | KRR1 | S284 | Sugiyama | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| P14314 | PRKCSH | S108 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q9UQE7 | SMC3 | Y471 | Sugiyama | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9UBS5 | GABBR1 | S868 | SIGNOR | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:24305054, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9844003, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:24305054, PubMed:9844003, PubMed:9872316). {ECO:0000250|UniProtKB:Q9Z0U4, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10773016, ECO:0000269|PubMed:10906333, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:36103875, ECO:0000269|PubMed:9844003, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.; FUNCTION: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. |
| Q7Z417 | NUFIP2 | S671 | Sugiyama | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q8WVC0 | LEO1 | S72 | Sugiyama | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| O60763 | USO1 | S776 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.000111 | 3.955 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000256 | 3.592 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.000329 | 3.483 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.000400 | 3.398 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.000651 | 3.187 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000981 | 3.008 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001002 | 2.999 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.001124 | 2.949 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.001563 | 2.806 |
| R-HSA-69481 | G2/M Checkpoints | 0.001350 | 2.870 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.001473 | 2.832 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.001486 | 2.828 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.001715 | 2.766 |
| R-HSA-1640170 | Cell Cycle | 0.001880 | 2.726 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.002234 | 2.651 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.002234 | 2.651 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.002646 | 2.577 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.002646 | 2.577 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.003018 | 2.520 |
| R-HSA-774815 | Nucleosome assembly | 0.003391 | 2.470 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.003391 | 2.470 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.003630 | 2.440 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003913 | 2.407 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.004153 | 2.382 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.004677 | 2.330 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.006024 | 2.220 |
| R-HSA-447041 | CHL1 interactions | 0.006024 | 2.220 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.006024 | 2.220 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.007234 | 2.141 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.008057 | 2.094 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.009955 | 2.002 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.009955 | 2.002 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.010724 | 1.970 |
| R-HSA-373755 | Semaphorin interactions | 0.009328 | 2.030 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.010480 | 1.980 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011362 | 1.945 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.011459 | 1.941 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.014746 | 1.831 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.014746 | 1.831 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.014746 | 1.831 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.014746 | 1.831 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.014415 | 1.841 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.014746 | 1.831 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.013057 | 1.884 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.012218 | 1.913 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.016524 | 1.782 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.016524 | 1.782 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.016524 | 1.782 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.016232 | 1.790 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.017173 | 1.765 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.017173 | 1.765 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.017173 | 1.765 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.019697 | 1.706 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.020337 | 1.692 |
| R-HSA-8876725 | Protein methylation | 0.020337 | 1.692 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.020172 | 1.695 |
| R-HSA-73886 | Chromosome Maintenance | 0.020131 | 1.696 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.021232 | 1.673 |
| R-HSA-212436 | Generic Transcription Pathway | 0.021538 | 1.667 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.022595 | 1.646 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.024479 | 1.611 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.028549 | 1.544 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.026982 | 1.569 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.028934 | 1.539 |
| R-HSA-3928664 | Ephrin signaling | 0.028934 | 1.539 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.044682 | 1.350 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.044682 | 1.350 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.044682 | 1.350 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.044682 | 1.350 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.044682 | 1.350 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.044682 | 1.350 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.044682 | 1.350 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.044682 | 1.350 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.044682 | 1.350 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.044682 | 1.350 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.044682 | 1.350 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.044682 | 1.350 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.033480 | 1.475 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.036683 | 1.436 |
| R-HSA-72172 | mRNA Splicing | 0.044908 | 1.348 |
| R-HSA-68877 | Mitotic Prometaphase | 0.035988 | 1.444 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.036286 | 1.440 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.041332 | 1.384 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.042250 | 1.374 |
| R-HSA-8953854 | Metabolism of RNA | 0.037217 | 1.429 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.041332 | 1.384 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.046756 | 1.330 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.043813 | 1.358 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.046756 | 1.330 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.041628 | 1.381 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.045069 | 1.346 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.041332 | 1.384 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.033684 | 1.473 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.041332 | 1.384 |
| R-HSA-597592 | Post-translational protein modification | 0.044012 | 1.356 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.040431 | 1.393 |
| R-HSA-186797 | Signaling by PDGF | 0.047025 | 1.328 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.049561 | 1.305 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.030374 | 1.517 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.052425 | 1.280 |
| R-HSA-399710 | Activation of AMPA receptors | 0.076886 | 1.114 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.097753 | 1.010 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.108010 | 0.967 |
| R-HSA-9613354 | Lipophagy | 0.128177 | 0.892 |
| R-HSA-4839744 | Signaling by APC mutants | 0.147890 | 0.830 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.147890 | 0.830 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.157580 | 0.802 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.157580 | 0.802 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.157580 | 0.802 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.167160 | 0.777 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.167160 | 0.777 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.061357 | 1.212 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.067577 | 1.170 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.195256 | 0.709 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.087383 | 1.059 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.090836 | 1.042 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.231255 | 0.636 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.240002 | 0.620 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.248650 | 0.604 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.248650 | 0.604 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.248650 | 0.604 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.248650 | 0.604 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.298519 | 0.525 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.298519 | 0.525 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.298519 | 0.525 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.298519 | 0.525 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.314399 | 0.503 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.314399 | 0.503 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.314399 | 0.503 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.322205 | 0.492 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.322205 | 0.492 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.291550 | 0.535 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.291550 | 0.535 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.257199 | 0.590 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.257199 | 0.590 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.222408 | 0.653 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.222408 | 0.653 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.306504 | 0.514 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.312531 | 0.505 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.057289 | 1.242 |
| R-HSA-169911 | Regulation of Apoptosis | 0.083972 | 1.076 |
| R-HSA-9857492 | Protein lipoylation | 0.195256 | 0.709 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.087383 | 1.059 |
| R-HSA-162592 | Integration of provirus | 0.157580 | 0.802 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.248650 | 0.604 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.171796 | 0.765 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.248650 | 0.604 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.073997 | 1.131 |
| R-HSA-6783984 | Glycine degradation | 0.213460 | 0.671 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.224225 | 0.649 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.070295 | 1.153 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.224225 | 0.649 |
| R-HSA-9930044 | Nuclear RNA decay | 0.073997 | 1.131 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.057584 | 1.240 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.211699 | 0.674 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.080603 | 1.094 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.292167 | 0.534 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.114199 | 0.942 |
| R-HSA-5693538 | Homology Directed Repair | 0.065909 | 1.181 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.066273 | 1.179 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.118150 | 0.928 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.157580 | 0.802 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.157580 | 0.802 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.157580 | 0.802 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.157580 | 0.802 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.167160 | 0.777 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.176632 | 0.753 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.080603 | 1.094 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.101425 | 0.994 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.150607 | 0.822 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.154567 | 0.811 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.059058 | 1.229 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.140289 | 0.853 |
| R-HSA-1500620 | Meiosis | 0.287343 | 0.542 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.231255 | 0.636 |
| R-HSA-202433 | Generation of second messenger molecules | 0.101425 | 0.994 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.118150 | 0.928 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.167160 | 0.777 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.195256 | 0.709 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.295754 | 0.529 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.167160 | 0.777 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.265652 | 0.576 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.184129 | 0.735 |
| R-HSA-447043 | Neurofascin interactions | 0.097753 | 1.010 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.064441 | 1.191 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.241009 | 0.618 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.128177 | 0.892 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.195256 | 0.709 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.094328 | 1.025 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.265652 | 0.576 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.274010 | 0.562 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.213194 | 0.671 |
| R-HSA-3371556 | Cellular response to heat stress | 0.201420 | 0.696 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.308343 | 0.511 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.097753 | 1.010 |
| R-HSA-164843 | 2-LTR circle formation | 0.138089 | 0.860 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.157580 | 0.802 |
| R-HSA-9710421 | Defective pyroptosis | 0.116038 | 0.935 |
| R-HSA-182971 | EGFR downregulation | 0.067577 | 1.170 |
| R-HSA-9664873 | Pexophagy | 0.138089 | 0.860 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.290442 | 0.537 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.128177 | 0.892 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.185997 | 0.730 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.083972 | 1.076 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.314399 | 0.503 |
| R-HSA-8951664 | Neddylation | 0.297378 | 0.527 |
| R-HSA-68886 | M Phase | 0.092823 | 1.032 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.231255 | 0.636 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.105028 | 0.979 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.257199 | 0.590 |
| R-HSA-447038 | NrCAM interactions | 0.076886 | 1.114 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.138089 | 0.860 |
| R-HSA-9683686 | Maturation of spike protein | 0.138089 | 0.860 |
| R-HSA-428540 | Activation of RAC1 | 0.157580 | 0.802 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.055347 | 1.257 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 0.195256 | 0.709 |
| R-HSA-429947 | Deadenylation of mRNA | 0.290442 | 0.537 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.298519 | 0.525 |
| R-HSA-913531 | Interferon Signaling | 0.316194 | 0.500 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.080603 | 1.094 |
| R-HSA-199991 | Membrane Trafficking | 0.083526 | 1.078 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.138858 | 0.857 |
| R-HSA-162906 | HIV Infection | 0.154379 | 0.811 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.094480 | 1.025 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.182795 | 0.738 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.064441 | 1.191 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.080603 | 1.094 |
| R-HSA-9663891 | Selective autophagy | 0.304151 | 0.517 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.150607 | 0.822 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.055546 | 1.255 |
| R-HSA-9612973 | Autophagy | 0.320110 | 0.495 |
| R-HSA-164944 | Nef and signal transduction | 0.097753 | 1.010 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.108010 | 0.967 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.147890 | 0.830 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.176632 | 0.753 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.185997 | 0.730 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.195256 | 0.709 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.195256 | 0.709 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.195256 | 0.709 |
| R-HSA-2028269 | Signaling by Hippo | 0.222408 | 0.653 |
| R-HSA-3214847 | HATs acetylate histones | 0.132507 | 0.878 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.236806 | 0.626 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.282273 | 0.549 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.204410 | 0.689 |
| R-HSA-9945266 | Differentiation of T cells | 0.204410 | 0.689 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.322205 | 0.492 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.245215 | 0.610 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.074827 | 1.126 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.137142 | 0.863 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.236806 | 0.626 |
| R-HSA-202403 | TCR signaling | 0.164502 | 0.784 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.186889 | 0.728 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.176632 | 0.753 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.176632 | 0.753 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.185997 | 0.730 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.306504 | 0.514 |
| R-HSA-69242 | S Phase | 0.123770 | 0.907 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.098424 | 1.007 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.091649 | 1.038 |
| R-HSA-9843745 | Adipogenesis | 0.237035 | 0.625 |
| R-HSA-73894 | DNA Repair | 0.146848 | 0.833 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.222755 | 0.652 |
| R-HSA-9675135 | Diseases of DNA repair | 0.127325 | 0.895 |
| R-HSA-216083 | Integrin cell surface interactions | 0.257850 | 0.589 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.185997 | 0.730 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.195256 | 0.709 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.195256 | 0.709 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.195256 | 0.709 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.060987 | 1.215 |
| R-HSA-9620244 | Long-term potentiation | 0.298519 | 0.525 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.314399 | 0.503 |
| R-HSA-177929 | Signaling by EGFR | 0.166563 | 0.778 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.304572 | 0.516 |
| R-HSA-422475 | Axon guidance | 0.321057 | 0.493 |
| R-HSA-1632852 | Macroautophagy | 0.270559 | 0.568 |
| R-HSA-69541 | Stabilization of p53 | 0.097858 | 1.009 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.270908 | 0.567 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.128177 | 0.892 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.204410 | 0.689 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.231255 | 0.636 |
| R-HSA-9833482 | PKR-mediated signaling | 0.080816 | 1.093 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.150607 | 0.822 |
| R-HSA-70635 | Urea cycle | 0.306504 | 0.514 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.195116 | 0.710 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.069455 | 1.158 |
| R-HSA-68882 | Mitotic Anaphase | 0.135156 | 0.869 |
| R-HSA-4839726 | Chromatin organization | 0.089812 | 1.047 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.136857 | 0.864 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.135689 | 0.867 |
| R-HSA-68875 | Mitotic Prophase | 0.198511 | 0.702 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.096144 | 1.017 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.232607 | 0.633 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.107765 | 0.968 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.135689 | 0.867 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.312531 | 0.505 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.240002 | 0.620 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.134988 | 0.870 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.232607 | 0.633 |
| R-HSA-449147 | Signaling by Interleukins | 0.123351 | 0.909 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.072581 | 1.139 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.091649 | 1.038 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.306504 | 0.514 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.224225 | 0.649 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.240002 | 0.620 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.138858 | 0.857 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.138858 | 0.857 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.290442 | 0.537 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.290442 | 0.537 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.290442 | 0.537 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.195116 | 0.710 |
| R-HSA-75153 | Apoptotic execution phase | 0.127325 | 0.895 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.067355 | 1.172 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.112326 | 0.950 |
| R-HSA-9824446 | Viral Infection Pathways | 0.165100 | 0.782 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.265652 | 0.576 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.314399 | 0.503 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.167174 | 0.777 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.100726 | 0.997 |
| R-HSA-446728 | Cell junction organization | 0.128205 | 0.892 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.101757 | 0.992 |
| R-HSA-109581 | Apoptosis | 0.152273 | 0.817 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.099609 | 1.002 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.156181 | 0.806 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.064441 | 1.191 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.231255 | 0.636 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.076649 | 1.115 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.282273 | 0.549 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.182795 | 0.738 |
| R-HSA-6807070 | PTEN Regulation | 0.104973 | 0.979 |
| R-HSA-418990 | Adherens junctions interactions | 0.138568 | 0.858 |
| R-HSA-1500931 | Cell-Cell communication | 0.188438 | 0.725 |
| R-HSA-421270 | Cell-cell junction organization | 0.199878 | 0.699 |
| R-HSA-5357801 | Programmed Cell Death | 0.117096 | 0.931 |
| R-HSA-3000170 | Syndecan interactions | 0.282273 | 0.549 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.178491 | 0.748 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.178491 | 0.748 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.134988 | 0.870 |
| R-HSA-8852135 | Protein ubiquitination | 0.245215 | 0.610 |
| R-HSA-162582 | Signal Transduction | 0.106784 | 0.971 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.258295 | 0.588 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.076886 | 1.114 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.224225 | 0.649 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.191266 | 0.718 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.282273 | 0.549 |
| R-HSA-168268 | Virus Assembly and Release | 0.204410 | 0.689 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.105028 | 0.979 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.127407 | 0.895 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.201420 | 0.696 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.248028 | 0.605 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.131665 | 0.881 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.203388 | 0.692 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.301468 | 0.521 |
| R-HSA-9679506 | SARS-CoV Infections | 0.215052 | 0.667 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.264418 | 0.578 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.249425 | 0.603 |
| R-HSA-162587 | HIV Life Cycle | 0.323219 | 0.491 |
| R-HSA-72312 | rRNA processing | 0.325567 | 0.487 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.329922 | 0.482 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.329922 | 0.482 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.329922 | 0.482 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.329922 | 0.482 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.337551 | 0.472 |
| R-HSA-2424491 | DAP12 signaling | 0.337551 | 0.472 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.337551 | 0.472 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.337551 | 0.472 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.337551 | 0.472 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.337551 | 0.472 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.337551 | 0.472 |
| R-HSA-8939211 | ESR-mediated signaling | 0.338447 | 0.471 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.345095 | 0.462 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.345095 | 0.462 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.345095 | 0.462 |
| R-HSA-186763 | Downstream signal transduction | 0.345095 | 0.462 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.345802 | 0.461 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.345802 | 0.461 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.352553 | 0.453 |
| R-HSA-1538133 | G0 and Early G1 | 0.352553 | 0.453 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.352553 | 0.453 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.352553 | 0.453 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.352553 | 0.453 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.352553 | 0.453 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.358151 | 0.446 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.359926 | 0.444 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.359926 | 0.444 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.359926 | 0.444 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.359926 | 0.444 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.359926 | 0.444 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.359926 | 0.444 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.359926 | 0.444 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.359926 | 0.444 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.359926 | 0.444 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.362249 | 0.441 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.366337 | 0.436 |
| R-HSA-390522 | Striated Muscle Contraction | 0.367216 | 0.435 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.367216 | 0.435 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.367216 | 0.435 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.367216 | 0.435 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.367216 | 0.435 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.367216 | 0.435 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.367216 | 0.435 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.367216 | 0.435 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.370415 | 0.431 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.370415 | 0.431 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.374423 | 0.427 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.374423 | 0.427 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.374423 | 0.427 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.374423 | 0.427 |
| R-HSA-5205647 | Mitophagy | 0.374423 | 0.427 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.378540 | 0.422 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.381549 | 0.418 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.381549 | 0.418 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.381549 | 0.418 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.381549 | 0.418 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.381549 | 0.418 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.382586 | 0.417 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.382586 | 0.417 |
| R-HSA-9675108 | Nervous system development | 0.384589 | 0.415 |
| R-HSA-8853659 | RET signaling | 0.388594 | 0.411 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.388594 | 0.411 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.388594 | 0.411 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.388594 | 0.411 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.388594 | 0.411 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.395043 | 0.403 |
| R-HSA-4641258 | Degradation of DVL | 0.395559 | 0.403 |
| R-HSA-4641257 | Degradation of AXIN | 0.395559 | 0.403 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.395559 | 0.403 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.395559 | 0.403 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.395559 | 0.403 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.398657 | 0.399 |
| R-HSA-5663205 | Infectious disease | 0.399733 | 0.398 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.402445 | 0.395 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.402445 | 0.395 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.402645 | 0.395 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.406633 | 0.391 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.409254 | 0.388 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.409254 | 0.388 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.409254 | 0.388 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.409254 | 0.388 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.409254 | 0.388 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.409254 | 0.388 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.409254 | 0.388 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.414533 | 0.382 |
| R-HSA-69275 | G2/M Transition | 0.415755 | 0.381 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.415985 | 0.381 |
| R-HSA-3371568 | Attenuation phase | 0.415985 | 0.381 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.415985 | 0.381 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.415985 | 0.381 |
| R-HSA-167169 | HIV Transcription Elongation | 0.415985 | 0.381 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.415985 | 0.381 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.415985 | 0.381 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.415985 | 0.381 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.415985 | 0.381 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.421812 | 0.375 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.422394 | 0.374 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.422639 | 0.374 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.422639 | 0.374 |
| R-HSA-9694548 | Maturation of spike protein | 0.422639 | 0.374 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.422639 | 0.374 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.422639 | 0.374 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.422639 | 0.374 |
| R-HSA-9607240 | FLT3 Signaling | 0.422639 | 0.374 |
| R-HSA-5617833 | Cilium Assembly | 0.427848 | 0.369 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.429219 | 0.367 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.429219 | 0.367 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.429219 | 0.367 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.429219 | 0.367 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.429219 | 0.367 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.429219 | 0.367 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.429219 | 0.367 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.429219 | 0.367 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.429219 | 0.367 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.430200 | 0.366 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.434082 | 0.362 |
| R-HSA-977444 | GABA B receptor activation | 0.435724 | 0.361 |
| R-HSA-991365 | Activation of GABAB receptors | 0.435724 | 0.361 |
| R-HSA-165159 | MTOR signalling | 0.435724 | 0.361 |
| R-HSA-373760 | L1CAM interactions | 0.437950 | 0.359 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.442155 | 0.354 |
| R-HSA-8854214 | TBC/RABGAPs | 0.442155 | 0.354 |
| R-HSA-9609690 | HCMV Early Events | 0.445822 | 0.351 |
| R-HSA-2172127 | DAP12 interactions | 0.448513 | 0.348 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.448513 | 0.348 |
| R-HSA-9907900 | Proteasome assembly | 0.448513 | 0.348 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.448513 | 0.348 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.448513 | 0.348 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.454799 | 0.342 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.454799 | 0.342 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.454799 | 0.342 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.454799 | 0.342 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.454799 | 0.342 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.454799 | 0.342 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.454799 | 0.342 |
| R-HSA-9824272 | Somitogenesis | 0.454799 | 0.342 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.461014 | 0.336 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.461014 | 0.336 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.461014 | 0.336 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.461014 | 0.336 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.461014 | 0.336 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.463571 | 0.334 |
| R-HSA-6798695 | Neutrophil degranulation | 0.465723 | 0.332 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.466506 | 0.331 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.467158 | 0.331 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.473232 | 0.325 |
| R-HSA-194138 | Signaling by VEGF | 0.475819 | 0.323 |
| R-HSA-69206 | G1/S Transition | 0.475819 | 0.323 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.479238 | 0.319 |
| R-HSA-9766229 | Degradation of CDH1 | 0.479238 | 0.319 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.485176 | 0.314 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.485899 | 0.313 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.491046 | 0.309 |
| R-HSA-912446 | Meiotic recombination | 0.491046 | 0.309 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.491046 | 0.309 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.491046 | 0.309 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.491046 | 0.309 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.495452 | 0.305 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.496850 | 0.304 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.496850 | 0.304 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.496850 | 0.304 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.496850 | 0.304 |
| R-HSA-1474165 | Reproduction | 0.497791 | 0.303 |
| R-HSA-1221632 | Meiotic synapsis | 0.502588 | 0.299 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.502588 | 0.299 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.502588 | 0.299 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.502588 | 0.299 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.502588 | 0.299 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.502588 | 0.299 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.504984 | 0.297 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.508261 | 0.294 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513869 | 0.289 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.513869 | 0.289 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.519414 | 0.284 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.519414 | 0.284 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.519414 | 0.284 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.519414 | 0.284 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.519414 | 0.284 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.524896 | 0.280 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.524896 | 0.280 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.530316 | 0.275 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.534625 | 0.272 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.535674 | 0.271 |
| R-HSA-191859 | snRNP Assembly | 0.535674 | 0.271 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.535674 | 0.271 |
| R-HSA-4085001 | Sialic acid metabolism | 0.535674 | 0.271 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.535674 | 0.271 |
| R-HSA-180786 | Extension of Telomeres | 0.535674 | 0.271 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.536521 | 0.270 |
| R-HSA-9664407 | Parasite infection | 0.536521 | 0.270 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.536521 | 0.270 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.539940 | 0.268 |
| R-HSA-977443 | GABA receptor activation | 0.540972 | 0.267 |
| R-HSA-983189 | Kinesins | 0.540972 | 0.267 |
| R-HSA-351202 | Metabolism of polyamines | 0.540972 | 0.267 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.545642 | 0.263 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.546209 | 0.263 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.546209 | 0.263 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.546725 | 0.262 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.551387 | 0.259 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.551387 | 0.259 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.551387 | 0.259 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.551387 | 0.259 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.552574 | 0.258 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.560086 | 0.252 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.566571 | 0.247 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.573165 | 0.242 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.577303 | 0.239 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.581243 | 0.236 |
| R-HSA-167172 | Transcription of the HIV genome | 0.581243 | 0.236 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.581243 | 0.236 |
| R-HSA-5218859 | Regulated Necrosis | 0.581243 | 0.236 |
| R-HSA-73887 | Death Receptor Signaling | 0.585961 | 0.232 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.590750 | 0.229 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.590750 | 0.229 |
| R-HSA-392499 | Metabolism of proteins | 0.594093 | 0.226 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.595146 | 0.225 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.595422 | 0.225 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.595422 | 0.225 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.595422 | 0.225 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.595422 | 0.225 |
| R-HSA-3000178 | ECM proteoglycans | 0.595422 | 0.225 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.595422 | 0.225 |
| R-HSA-9609646 | HCMV Infection | 0.597609 | 0.224 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.598473 | 0.223 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.600041 | 0.222 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.600041 | 0.222 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.600041 | 0.222 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.604608 | 0.219 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.604608 | 0.219 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.605947 | 0.218 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.609123 | 0.215 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.609123 | 0.215 |
| R-HSA-5688426 | Deubiquitination | 0.610016 | 0.215 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.613587 | 0.212 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.613587 | 0.212 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.613587 | 0.212 |
| R-HSA-5689603 | UCH proteinases | 0.617999 | 0.209 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.622362 | 0.206 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.626676 | 0.203 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.626676 | 0.203 |
| R-HSA-5619084 | ABC transporter disorders | 0.626676 | 0.203 |
| R-HSA-4086400 | PCP/CE pathway | 0.626676 | 0.203 |
| R-HSA-9659379 | Sensory processing of sound | 0.630940 | 0.200 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.635156 | 0.197 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.639322 | 0.194 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.639324 | 0.194 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.640031 | 0.194 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.641074 | 0.193 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.643444 | 0.191 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.645686 | 0.190 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.645686 | 0.190 |
| R-HSA-2262752 | Cellular responses to stress | 0.645939 | 0.190 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.647518 | 0.189 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.648487 | 0.188 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.651270 | 0.186 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.651270 | 0.186 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.651545 | 0.186 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.651545 | 0.186 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.659463 | 0.181 |
| R-HSA-112316 | Neuronal System | 0.659684 | 0.181 |
| R-HSA-168255 | Influenza Infection | 0.662230 | 0.179 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.663355 | 0.178 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.663355 | 0.178 |
| R-HSA-2559583 | Cellular Senescence | 0.664927 | 0.177 |
| R-HSA-70268 | Pyruvate metabolism | 0.667203 | 0.176 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.667203 | 0.176 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.670368 | 0.174 |
| R-HSA-9658195 | Leishmania infection | 0.670368 | 0.174 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.671006 | 0.173 |
| R-HSA-156902 | Peptide chain elongation | 0.671006 | 0.173 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.671006 | 0.173 |
| R-HSA-202424 | Downstream TCR signaling | 0.678484 | 0.168 |
| R-HSA-1280218 | Adaptive Immune System | 0.680232 | 0.167 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.685794 | 0.164 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.689386 | 0.162 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.689386 | 0.162 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.692937 | 0.159 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.692937 | 0.159 |
| R-HSA-1474290 | Collagen formation | 0.696449 | 0.157 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.703351 | 0.153 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.703351 | 0.153 |
| R-HSA-195721 | Signaling by WNT | 0.705999 | 0.151 |
| R-HSA-1296071 | Potassium Channels | 0.706744 | 0.151 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.706744 | 0.151 |
| R-HSA-157579 | Telomere Maintenance | 0.710098 | 0.149 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.710098 | 0.149 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.715299 | 0.146 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.716692 | 0.145 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.716692 | 0.145 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.719933 | 0.143 |
| R-HSA-70171 | Glycolysis | 0.719933 | 0.143 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.719933 | 0.143 |
| R-HSA-1643685 | Disease | 0.721406 | 0.142 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.722284 | 0.141 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.732532 | 0.135 |
| R-HSA-9833110 | RSV-host interactions | 0.735593 | 0.133 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.738618 | 0.132 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.741610 | 0.130 |
| R-HSA-397014 | Muscle contraction | 0.744536 | 0.128 |
| R-HSA-69239 | Synthesis of DNA | 0.744567 | 0.128 |
| R-HSA-211000 | Gene Silencing by RNA | 0.744567 | 0.128 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.750381 | 0.125 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.753239 | 0.123 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.758856 | 0.120 |
| R-HSA-1474244 | Extracellular matrix organization | 0.766681 | 0.115 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.772350 | 0.112 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.777535 | 0.109 |
| R-HSA-70326 | Glucose metabolism | 0.777535 | 0.109 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.777535 | 0.109 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.792395 | 0.101 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.794774 | 0.100 |
| R-HSA-157118 | Signaling by NOTCH | 0.798895 | 0.098 |
| R-HSA-168256 | Immune System | 0.803459 | 0.095 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.806268 | 0.094 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.810788 | 0.091 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.815000 | 0.089 |
| R-HSA-9909396 | Circadian clock | 0.817121 | 0.088 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.817121 | 0.088 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.827370 | 0.082 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.831307 | 0.080 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.831307 | 0.080 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.842570 | 0.074 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.844399 | 0.073 |
| R-HSA-166520 | Signaling by NTRKs | 0.851420 | 0.070 |
| R-HSA-9758941 | Gastrulation | 0.853126 | 0.069 |
| R-HSA-168249 | Innate Immune System | 0.853177 | 0.069 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.854812 | 0.068 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.858127 | 0.066 |
| R-HSA-9609507 | Protein localization | 0.859756 | 0.066 |
| R-HSA-69306 | DNA Replication | 0.859756 | 0.066 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.861345 | 0.065 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.862958 | 0.064 |
| R-HSA-9610379 | HCMV Late Events | 0.866088 | 0.062 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.866088 | 0.062 |
| R-HSA-877300 | Interferon gamma signaling | 0.869147 | 0.061 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.869849 | 0.061 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.870650 | 0.060 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.877875 | 0.057 |
| R-HSA-5619102 | SLC transporter disorders | 0.880702 | 0.055 |
| R-HSA-72306 | tRNA processing | 0.886093 | 0.053 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.889976 | 0.051 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.919498 | 0.036 |
| R-HSA-428157 | Sphingolipid metabolism | 0.920432 | 0.036 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.922255 | 0.035 |
| R-HSA-6805567 | Keratinization | 0.925776 | 0.033 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.931561 | 0.031 |
| R-HSA-1266738 | Developmental Biology | 0.947762 | 0.023 |
| R-HSA-72766 | Translation | 0.965823 | 0.015 |
| R-HSA-1483257 | Phospholipid metabolism | 0.973616 | 0.012 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.978290 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 0.981189 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.991411 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992964 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995998 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.999050 | 0.000 |
| R-HSA-109582 | Hemostasis | 0.999148 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999179 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999616 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999993 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999997 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.804 | 0.500 | 2 | 0.904 |
COT |
0.780 | 0.210 | 2 | 0.600 |
CLK3 |
0.771 | 0.150 | 1 | 0.804 |
GRK1 |
0.766 | 0.143 | -2 | 0.822 |
PLK2 |
0.763 | 0.469 | -3 | 0.604 |
BMPR1B |
0.760 | 0.242 | 1 | 0.797 |
MOS |
0.757 | 0.120 | 1 | 0.850 |
DSTYK |
0.757 | 0.095 | 2 | 0.620 |
IKKA |
0.756 | 0.138 | -2 | 0.714 |
CDC7 |
0.754 | 0.041 | 1 | 0.847 |
PIM3 |
0.753 | -0.005 | -3 | 0.180 |
CAMK2G |
0.753 | 0.077 | 2 | 0.609 |
BMPR1A |
0.751 | 0.272 | 1 | 0.785 |
KIS |
0.751 | 0.067 | 1 | 0.647 |
IKKB |
0.750 | 0.030 | -2 | 0.727 |
PLK3 |
0.750 | 0.281 | 2 | 0.568 |
GRK6 |
0.750 | 0.119 | 1 | 0.815 |
GRK7 |
0.750 | 0.138 | 1 | 0.736 |
PRPK |
0.749 | 0.034 | -1 | 0.808 |
TGFBR1 |
0.749 | 0.207 | -2 | 0.878 |
CAMK2B |
0.748 | 0.107 | 2 | 0.657 |
GCN2 |
0.746 | 0.006 | 2 | 0.496 |
ATM |
0.746 | 0.125 | 1 | 0.772 |
GRK4 |
0.745 | 0.079 | -2 | 0.847 |
NDR2 |
0.745 | -0.046 | -3 | 0.167 |
ALK2 |
0.745 | 0.245 | -2 | 0.893 |
PIM1 |
0.743 | -0.007 | -3 | 0.151 |
SKMLCK |
0.743 | 0.016 | -2 | 0.832 |
RAF1 |
0.743 | -0.036 | 1 | 0.815 |
TBK1 |
0.743 | 0.022 | 1 | 0.705 |
ATR |
0.743 | 0.017 | 1 | 0.812 |
RSK2 |
0.742 | -0.025 | -3 | 0.145 |
BMPR2 |
0.742 | 0.071 | -2 | 0.873 |
LATS1 |
0.742 | 0.095 | -3 | 0.175 |
CAMK1B |
0.742 | -0.051 | -3 | 0.177 |
GRK5 |
0.742 | -0.018 | -3 | 0.208 |
SRPK1 |
0.741 | -0.010 | -3 | 0.135 |
CLK2 |
0.741 | 0.053 | -3 | 0.154 |
PDHK4 |
0.740 | -0.063 | 1 | 0.811 |
ACVR2B |
0.740 | 0.175 | -2 | 0.845 |
PRKX |
0.739 | 0.018 | -3 | 0.112 |
IKKE |
0.739 | 0.003 | 1 | 0.706 |
MTOR |
0.739 | -0.067 | 1 | 0.736 |
ULK2 |
0.738 | -0.137 | 2 | 0.503 |
MAPKAPK2 |
0.738 | -0.020 | -3 | 0.129 |
NEK6 |
0.737 | -0.069 | -2 | 0.839 |
CDKL1 |
0.737 | -0.059 | -3 | 0.159 |
TGFBR2 |
0.737 | 0.022 | -2 | 0.863 |
SRPK2 |
0.737 | -0.020 | -3 | 0.123 |
PKN3 |
0.736 | -0.064 | -3 | 0.158 |
ACVR2A |
0.736 | 0.158 | -2 | 0.838 |
RSK4 |
0.736 | -0.008 | -3 | 0.146 |
ULK1 |
0.736 | -0.114 | -3 | 0.168 |
ALK4 |
0.736 | 0.124 | -2 | 0.894 |
MARK4 |
0.735 | -0.035 | 4 | 0.780 |
MLK1 |
0.735 | -0.027 | 2 | 0.512 |
CHAK2 |
0.735 | -0.033 | -1 | 0.810 |
PLK1 |
0.734 | 0.047 | -2 | 0.819 |
CAMK2A |
0.734 | 0.014 | 2 | 0.595 |
HUNK |
0.734 | -0.087 | 2 | 0.523 |
NEK7 |
0.734 | -0.117 | -3 | 0.165 |
LATS2 |
0.733 | -0.050 | -5 | 0.695 |
PKCD |
0.733 | -0.044 | 2 | 0.501 |
CK2A2 |
0.733 | 0.148 | 1 | 0.699 |
P90RSK |
0.733 | -0.060 | -3 | 0.149 |
CK1E |
0.732 | -0.043 | -3 | 0.139 |
PRKD1 |
0.731 | -0.075 | -3 | 0.135 |
NDR1 |
0.731 | -0.092 | -3 | 0.159 |
NLK |
0.731 | -0.090 | 1 | 0.782 |
MLK4 |
0.731 | 0.055 | 2 | 0.469 |
GRK2 |
0.731 | 0.060 | -2 | 0.755 |
PDHK1 |
0.731 | -0.135 | 1 | 0.804 |
CAMK2D |
0.731 | -0.030 | -3 | 0.132 |
PKACB |
0.730 | -0.006 | -2 | 0.699 |
PRKD2 |
0.730 | -0.070 | -3 | 0.123 |
RSK3 |
0.730 | -0.056 | -3 | 0.166 |
MSK2 |
0.730 | -0.044 | -3 | 0.128 |
CAMLCK |
0.730 | -0.046 | -2 | 0.837 |
P70S6KB |
0.729 | -0.070 | -3 | 0.145 |
MLK3 |
0.728 | -0.010 | 2 | 0.462 |
BCKDK |
0.728 | -0.074 | -1 | 0.753 |
NIK |
0.728 | -0.130 | -3 | 0.184 |
SRPK3 |
0.728 | -0.030 | -3 | 0.141 |
MSK1 |
0.728 | -0.011 | -3 | 0.129 |
PKACG |
0.727 | -0.052 | -2 | 0.756 |
CK1D |
0.727 | -0.041 | -3 | 0.099 |
GRK3 |
0.727 | 0.065 | -2 | 0.731 |
MST4 |
0.727 | -0.076 | 2 | 0.521 |
CDK1 |
0.727 | 0.039 | 1 | 0.599 |
HIPK4 |
0.726 | -0.059 | 1 | 0.762 |
ICK |
0.726 | -0.063 | -3 | 0.156 |
AMPKA1 |
0.726 | -0.100 | -3 | 0.155 |
ERK5 |
0.725 | -0.073 | 1 | 0.723 |
CDKL5 |
0.725 | -0.080 | -3 | 0.145 |
RIPK3 |
0.725 | -0.120 | 3 | 0.713 |
DAPK2 |
0.725 | -0.095 | -3 | 0.166 |
TTBK2 |
0.725 | -0.088 | 2 | 0.434 |
CLK4 |
0.725 | -0.017 | -3 | 0.141 |
NUAK2 |
0.724 | -0.111 | -3 | 0.161 |
PKN2 |
0.724 | -0.125 | -3 | 0.137 |
TSSK2 |
0.724 | -0.058 | -5 | 0.721 |
AURC |
0.724 | -0.018 | -2 | 0.693 |
TLK2 |
0.724 | 0.040 | 1 | 0.764 |
DLK |
0.723 | -0.100 | 1 | 0.779 |
DNAPK |
0.723 | 0.066 | 1 | 0.717 |
PKR |
0.722 | 0.011 | 1 | 0.814 |
PAK1 |
0.722 | -0.054 | -2 | 0.761 |
MAPKAPK3 |
0.722 | -0.112 | -3 | 0.118 |
PKCB |
0.722 | -0.076 | 2 | 0.453 |
ANKRD3 |
0.721 | -0.111 | 1 | 0.805 |
AURA |
0.721 | 0.025 | -2 | 0.673 |
CDK8 |
0.720 | -0.017 | 1 | 0.614 |
CK1G1 |
0.720 | -0.073 | -3 | 0.138 |
WNK1 |
0.720 | -0.142 | -2 | 0.815 |
TSSK1 |
0.720 | -0.078 | -3 | 0.166 |
CK1A2 |
0.720 | -0.061 | -3 | 0.102 |
BRSK1 |
0.720 | -0.076 | -3 | 0.141 |
CK2A1 |
0.719 | 0.111 | 1 | 0.677 |
AMPKA2 |
0.719 | -0.104 | -3 | 0.143 |
CLK1 |
0.719 | -0.034 | -3 | 0.130 |
MARK2 |
0.718 | -0.028 | 4 | 0.697 |
QSK |
0.718 | -0.071 | 4 | 0.757 |
DYRK2 |
0.718 | -0.031 | 1 | 0.667 |
JNK3 |
0.718 | 0.017 | 1 | 0.609 |
NIM1 |
0.718 | -0.122 | 3 | 0.769 |
MARK3 |
0.718 | -0.038 | 4 | 0.719 |
IRE2 |
0.718 | -0.060 | 2 | 0.469 |
CDK5 |
0.718 | 0.007 | 1 | 0.647 |
AKT2 |
0.718 | -0.052 | -3 | 0.112 |
MASTL |
0.717 | -0.212 | -2 | 0.772 |
NEK9 |
0.717 | -0.196 | 2 | 0.506 |
BRAF |
0.716 | 0.018 | -4 | 0.825 |
MLK2 |
0.716 | -0.140 | 2 | 0.518 |
PKCA |
0.716 | -0.086 | 2 | 0.443 |
PKCG |
0.716 | -0.100 | 2 | 0.447 |
SIK |
0.716 | -0.089 | -3 | 0.130 |
MNK1 |
0.715 | -0.070 | -2 | 0.792 |
CAMK4 |
0.714 | -0.136 | -3 | 0.144 |
YSK4 |
0.714 | -0.073 | 1 | 0.732 |
WNK3 |
0.714 | -0.220 | 1 | 0.771 |
MNK2 |
0.714 | -0.067 | -2 | 0.774 |
PKACA |
0.714 | -0.023 | -2 | 0.656 |
PRP4 |
0.714 | -0.048 | -3 | 0.160 |
MYLK4 |
0.713 | -0.057 | -2 | 0.773 |
RIPK1 |
0.713 | -0.173 | 1 | 0.778 |
TLK1 |
0.713 | 0.007 | -2 | 0.851 |
PRKD3 |
0.713 | -0.098 | -3 | 0.121 |
NUAK1 |
0.713 | -0.115 | -3 | 0.148 |
JNK2 |
0.713 | 0.015 | 1 | 0.579 |
MEK1 |
0.713 | -0.110 | 2 | 0.552 |
IRE1 |
0.713 | -0.127 | 1 | 0.764 |
MARK1 |
0.713 | -0.051 | 4 | 0.735 |
CDK19 |
0.712 | -0.024 | 1 | 0.579 |
CHK1 |
0.712 | -0.048 | -3 | 0.211 |
AURB |
0.712 | -0.029 | -2 | 0.689 |
CDK2 |
0.712 | 0.002 | 1 | 0.672 |
MEKK3 |
0.712 | -0.041 | 1 | 0.750 |
PKCH |
0.712 | -0.104 | 2 | 0.440 |
PIM2 |
0.711 | -0.065 | -3 | 0.128 |
PINK1 |
0.711 | -0.087 | 1 | 0.785 |
CDK3 |
0.711 | 0.034 | 1 | 0.537 |
PAK3 |
0.711 | -0.108 | -2 | 0.753 |
PASK |
0.711 | -0.015 | -3 | 0.178 |
CAMK1D |
0.711 | -0.055 | -3 | 0.111 |
CAMK1G |
0.710 | -0.097 | -3 | 0.122 |
HIPK2 |
0.710 | -0.020 | 1 | 0.585 |
PKCZ |
0.710 | -0.108 | 2 | 0.469 |
VRK2 |
0.709 | -0.217 | 1 | 0.822 |
SMG1 |
0.709 | -0.046 | 1 | 0.771 |
P38G |
0.709 | 0.009 | 1 | 0.509 |
PLK4 |
0.709 | -0.105 | 2 | 0.423 |
SGK3 |
0.709 | -0.087 | -3 | 0.115 |
PKG2 |
0.709 | -0.061 | -2 | 0.702 |
PERK |
0.708 | -0.057 | -2 | 0.854 |
DCAMKL1 |
0.708 | -0.104 | -3 | 0.145 |
CHAK1 |
0.708 | -0.126 | 2 | 0.431 |
MEKK2 |
0.707 | -0.026 | 2 | 0.506 |
QIK |
0.707 | -0.160 | -3 | 0.132 |
DYRK4 |
0.707 | -0.010 | 1 | 0.591 |
GSK3A |
0.707 | 0.011 | 4 | 0.389 |
PAK2 |
0.707 | -0.093 | -2 | 0.752 |
MELK |
0.707 | -0.158 | -3 | 0.126 |
HIPK1 |
0.706 | -0.043 | 1 | 0.683 |
MEKK1 |
0.705 | -0.081 | 1 | 0.760 |
BRSK2 |
0.705 | -0.140 | -3 | 0.125 |
CDK18 |
0.705 | -0.033 | 1 | 0.566 |
NEK2 |
0.704 | -0.195 | 2 | 0.474 |
CDK13 |
0.704 | -0.044 | 1 | 0.607 |
PAK6 |
0.703 | -0.076 | -2 | 0.694 |
ZAK |
0.703 | -0.091 | 1 | 0.729 |
AKT1 |
0.703 | -0.061 | -3 | 0.103 |
DYRK1A |
0.703 | -0.064 | 1 | 0.689 |
P38B |
0.703 | -0.008 | 1 | 0.579 |
DRAK1 |
0.702 | -0.104 | 1 | 0.726 |
TAO3 |
0.702 | -0.055 | 1 | 0.746 |
MST2 |
0.702 | 0.026 | 1 | 0.770 |
P38A |
0.702 | -0.020 | 1 | 0.642 |
SSTK |
0.702 | -0.082 | 4 | 0.735 |
DCAMKL2 |
0.701 | -0.109 | -3 | 0.152 |
ERK1 |
0.701 | -0.019 | 1 | 0.570 |
CDK17 |
0.701 | -0.027 | 1 | 0.518 |
ERK2 |
0.701 | -0.035 | 1 | 0.622 |
MAPKAPK5 |
0.700 | -0.139 | -3 | 0.102 |
SGK1 |
0.700 | -0.047 | -3 | 0.095 |
CDK7 |
0.700 | -0.069 | 1 | 0.629 |
GAK |
0.700 | -0.013 | 1 | 0.796 |
HRI |
0.700 | -0.134 | -2 | 0.838 |
SMMLCK |
0.700 | -0.082 | -3 | 0.143 |
PHKG1 |
0.700 | -0.169 | -3 | 0.142 |
NEK5 |
0.699 | -0.160 | 1 | 0.781 |
DYRK3 |
0.699 | -0.042 | 1 | 0.689 |
JNK1 |
0.699 | 0.017 | 1 | 0.570 |
CK1A |
0.699 | -0.061 | -3 | 0.087 |
P38D |
0.699 | 0.009 | 1 | 0.531 |
DAPK3 |
0.699 | -0.040 | -3 | 0.144 |
DYRK1B |
0.699 | -0.041 | 1 | 0.621 |
MEK5 |
0.699 | -0.201 | 2 | 0.525 |
SNRK |
0.698 | -0.211 | 2 | 0.443 |
PKCT |
0.697 | -0.114 | 2 | 0.450 |
P70S6K |
0.697 | -0.111 | -3 | 0.108 |
AKT3 |
0.697 | -0.053 | -3 | 0.091 |
GSK3B |
0.696 | -0.036 | 4 | 0.374 |
CAMKK1 |
0.695 | -0.134 | -2 | 0.743 |
CDK12 |
0.695 | -0.049 | 1 | 0.581 |
NEK8 |
0.694 | -0.141 | 2 | 0.497 |
CDK16 |
0.694 | -0.026 | 1 | 0.536 |
ALPHAK3 |
0.694 | 0.142 | -1 | 0.748 |
TTBK1 |
0.694 | -0.131 | 2 | 0.387 |
MST3 |
0.693 | -0.135 | 2 | 0.489 |
EEF2K |
0.693 | -0.031 | 3 | 0.841 |
SBK |
0.693 | -0.056 | -3 | 0.082 |
CAMK1A |
0.692 | -0.082 | -3 | 0.101 |
PKCE |
0.692 | -0.087 | 2 | 0.427 |
GCK |
0.691 | -0.054 | 1 | 0.769 |
DAPK1 |
0.691 | -0.049 | -3 | 0.137 |
MPSK1 |
0.690 | -0.091 | 1 | 0.734 |
IRAK4 |
0.690 | -0.183 | 1 | 0.770 |
TTK |
0.690 | 0.072 | -2 | 0.845 |
TNIK |
0.690 | -0.044 | 3 | 0.857 |
ERK7 |
0.689 | -0.055 | 2 | 0.302 |
HIPK3 |
0.689 | -0.087 | 1 | 0.666 |
MAK |
0.689 | -0.034 | -2 | 0.685 |
CDK14 |
0.689 | -0.065 | 1 | 0.614 |
WNK4 |
0.688 | -0.183 | -2 | 0.798 |
LKB1 |
0.688 | -0.168 | -3 | 0.133 |
CDK9 |
0.688 | -0.084 | 1 | 0.614 |
ROCK2 |
0.688 | -0.058 | -3 | 0.129 |
CHK2 |
0.688 | -0.105 | -3 | 0.091 |
TAO2 |
0.687 | -0.131 | 2 | 0.539 |
TAK1 |
0.687 | -0.105 | 1 | 0.779 |
PHKG2 |
0.687 | -0.158 | -3 | 0.130 |
PKCI |
0.687 | -0.129 | 2 | 0.437 |
YANK3 |
0.687 | -0.050 | 2 | 0.286 |
CAMKK2 |
0.687 | -0.170 | -2 | 0.735 |
CK1G3 |
0.686 | -0.050 | -3 | 0.072 |
MINK |
0.686 | -0.062 | 1 | 0.760 |
IRAK1 |
0.686 | -0.174 | -1 | 0.662 |
MST1 |
0.685 | -0.070 | 1 | 0.755 |
NEK11 |
0.685 | -0.201 | 1 | 0.748 |
MRCKA |
0.685 | -0.075 | -3 | 0.121 |
MRCKB |
0.685 | -0.072 | -3 | 0.112 |
PDHK3_TYR |
0.684 | 0.050 | 4 | 0.837 |
PAK5 |
0.684 | -0.088 | -2 | 0.637 |
PDK1 |
0.684 | -0.139 | 1 | 0.743 |
HGK |
0.683 | -0.101 | 3 | 0.845 |
OSR1 |
0.683 | -0.010 | 2 | 0.484 |
PAK4 |
0.683 | -0.076 | -2 | 0.651 |
CDK10 |
0.682 | -0.066 | 1 | 0.601 |
SLK |
0.681 | -0.091 | -2 | 0.681 |
STK33 |
0.681 | -0.140 | 2 | 0.389 |
DMPK1 |
0.680 | -0.046 | -3 | 0.126 |
BMPR2_TYR |
0.680 | 0.106 | -1 | 0.829 |
NEK4 |
0.680 | -0.202 | 1 | 0.761 |
MAP2K6_TYR |
0.680 | 0.088 | -1 | 0.834 |
VRK1 |
0.679 | -0.163 | 2 | 0.535 |
KHS2 |
0.678 | -0.057 | 1 | 0.774 |
PDHK4_TYR |
0.678 | 0.037 | 2 | 0.596 |
LRRK2 |
0.678 | -0.182 | 2 | 0.520 |
HPK1 |
0.678 | -0.112 | 1 | 0.767 |
PKN1 |
0.678 | -0.135 | -3 | 0.098 |
KHS1 |
0.677 | -0.083 | 1 | 0.760 |
MAP3K15 |
0.676 | -0.175 | 1 | 0.706 |
EPHA6 |
0.676 | 0.099 | -1 | 0.822 |
CDK6 |
0.676 | -0.049 | 1 | 0.588 |
MOK |
0.676 | -0.065 | 1 | 0.694 |
PDHK1_TYR |
0.675 | 0.050 | -1 | 0.847 |
NEK1 |
0.675 | -0.215 | 1 | 0.759 |
LOK |
0.674 | -0.141 | -2 | 0.730 |
MEKK6 |
0.673 | -0.218 | 1 | 0.730 |
PKG1 |
0.673 | -0.079 | -2 | 0.628 |
ROCK1 |
0.673 | -0.070 | -3 | 0.119 |
EPHA4 |
0.672 | 0.103 | 2 | 0.577 |
MAP2K4_TYR |
0.671 | -0.043 | -1 | 0.825 |
CDK4 |
0.671 | -0.056 | 1 | 0.573 |
TESK1_TYR |
0.671 | -0.098 | 3 | 0.869 |
MEK2 |
0.670 | -0.192 | 2 | 0.514 |
PBK |
0.670 | -0.093 | 1 | 0.706 |
CK1G2 |
0.670 | -0.029 | -3 | 0.108 |
MAP2K7_TYR |
0.669 | -0.120 | 2 | 0.575 |
CRIK |
0.669 | -0.075 | -3 | 0.104 |
BUB1 |
0.669 | -0.089 | -5 | 0.678 |
FER |
0.668 | 0.126 | 1 | 0.821 |
INSRR |
0.668 | 0.115 | 3 | 0.712 |
TXK |
0.667 | 0.152 | 1 | 0.781 |
EPHB4 |
0.667 | 0.080 | -1 | 0.787 |
HASPIN |
0.667 | -0.059 | -1 | 0.652 |
YSK1 |
0.666 | -0.170 | 2 | 0.474 |
YES1 |
0.665 | 0.139 | -1 | 0.768 |
SRMS |
0.665 | 0.154 | 1 | 0.810 |
FYN |
0.665 | 0.198 | -1 | 0.733 |
PKMYT1_TYR |
0.664 | -0.134 | 3 | 0.825 |
RIPK2 |
0.664 | -0.227 | 1 | 0.684 |
PINK1_TYR |
0.664 | -0.120 | 1 | 0.784 |
EPHB2 |
0.664 | 0.128 | -1 | 0.768 |
RET |
0.664 | 0.014 | 1 | 0.750 |
MYO3A |
0.663 | -0.090 | 1 | 0.772 |
SYK |
0.663 | 0.154 | -1 | 0.756 |
PTK2 |
0.661 | 0.119 | -1 | 0.770 |
FGFR2 |
0.661 | 0.069 | 3 | 0.760 |
BIKE |
0.661 | -0.031 | 1 | 0.681 |
BLK |
0.661 | 0.132 | -1 | 0.757 |
CSF1R |
0.661 | 0.058 | 3 | 0.745 |
MYO3B |
0.660 | -0.119 | 2 | 0.488 |
ABL2 |
0.660 | 0.078 | -1 | 0.752 |
FGR |
0.659 | 0.015 | 1 | 0.777 |
LCK |
0.659 | 0.109 | -1 | 0.751 |
LIMK2_TYR |
0.659 | -0.151 | -3 | 0.167 |
KIT |
0.658 | 0.043 | 3 | 0.752 |
EGFR |
0.658 | 0.112 | 1 | 0.611 |
EPHA5 |
0.658 | 0.131 | 2 | 0.598 |
TYRO3 |
0.657 | -0.046 | 3 | 0.763 |
EPHB1 |
0.657 | 0.034 | 1 | 0.796 |
ASK1 |
0.657 | -0.159 | 1 | 0.699 |
FLT3 |
0.656 | 0.033 | 3 | 0.751 |
NEK3 |
0.656 | -0.228 | 1 | 0.697 |
ROS1 |
0.656 | -0.080 | 3 | 0.729 |
JAK3 |
0.656 | -0.031 | 1 | 0.717 |
EPHB3 |
0.655 | 0.021 | -1 | 0.764 |
HCK |
0.655 | 0.057 | -1 | 0.740 |
FGFR3 |
0.655 | 0.063 | 3 | 0.735 |
LIMK1_TYR |
0.655 | -0.194 | 2 | 0.558 |
TYK2 |
0.655 | -0.115 | 1 | 0.749 |
EPHA7 |
0.654 | 0.056 | 2 | 0.571 |
YANK2 |
0.654 | -0.061 | 2 | 0.310 |
DDR1 |
0.654 | -0.100 | 4 | 0.741 |
STLK3 |
0.654 | -0.126 | 1 | 0.699 |
ABL1 |
0.653 | 0.032 | -1 | 0.741 |
MST1R |
0.653 | -0.107 | 3 | 0.764 |
EPHA8 |
0.652 | 0.104 | -1 | 0.749 |
ITK |
0.652 | 0.020 | -1 | 0.701 |
JAK2 |
0.652 | -0.095 | 1 | 0.738 |
FGFR4 |
0.652 | 0.111 | -1 | 0.741 |
MATK |
0.652 | 0.039 | -1 | 0.708 |
FLT1 |
0.651 | 0.010 | -1 | 0.813 |
PDGFRB |
0.651 | -0.041 | 3 | 0.761 |
NTRK1 |
0.650 | 0.031 | -1 | 0.778 |
ERBB2 |
0.650 | 0.024 | 1 | 0.707 |
TAO1 |
0.650 | -0.153 | 1 | 0.677 |
EPHA3 |
0.650 | -0.002 | 2 | 0.556 |
KDR |
0.649 | -0.049 | 3 | 0.711 |
TEK |
0.649 | -0.053 | 3 | 0.699 |
MET |
0.649 | 0.010 | 3 | 0.732 |
MERTK |
0.649 | 0.017 | 3 | 0.730 |
LYN |
0.649 | 0.123 | 3 | 0.670 |
FGFR1 |
0.649 | -0.031 | 3 | 0.723 |
SRC |
0.649 | 0.123 | -1 | 0.731 |
INSR |
0.648 | 0.025 | 3 | 0.688 |
BMX |
0.648 | 0.023 | -1 | 0.640 |
TEC |
0.647 | 0.019 | -1 | 0.636 |
PTK6 |
0.646 | -0.006 | -1 | 0.651 |
LTK |
0.646 | -0.006 | 3 | 0.689 |
CSK |
0.645 | 0.106 | 2 | 0.559 |
EPHA2 |
0.644 | 0.082 | -1 | 0.730 |
ALK |
0.644 | -0.026 | 3 | 0.663 |
BTK |
0.644 | 0.000 | -1 | 0.652 |
FRK |
0.644 | 0.035 | -1 | 0.753 |
FLT4 |
0.642 | -0.040 | 3 | 0.715 |
AXL |
0.642 | -0.064 | 3 | 0.732 |
ERBB4 |
0.642 | 0.070 | 1 | 0.653 |
AAK1 |
0.641 | -0.017 | 1 | 0.581 |
IGF1R |
0.641 | 0.051 | 3 | 0.631 |
NTRK3 |
0.641 | -0.001 | -1 | 0.740 |
PTK2B |
0.640 | 0.006 | -1 | 0.693 |
TNK2 |
0.639 | -0.133 | 3 | 0.702 |
WEE1_TYR |
0.639 | -0.091 | -1 | 0.677 |
NTRK2 |
0.639 | -0.048 | 3 | 0.709 |
TNNI3K_TYR |
0.638 | -0.133 | 1 | 0.745 |
PDGFRA |
0.638 | -0.129 | 3 | 0.759 |
DDR2 |
0.637 | -0.044 | 3 | 0.689 |
NEK10_TYR |
0.637 | -0.129 | 1 | 0.638 |
TNK1 |
0.637 | -0.163 | 3 | 0.741 |
JAK1 |
0.635 | -0.117 | 1 | 0.687 |
EPHA1 |
0.634 | -0.064 | 3 | 0.705 |
ZAP70 |
0.629 | 0.019 | -1 | 0.680 |
FES |
0.619 | -0.018 | -1 | 0.628 |
MUSK |
0.612 | -0.123 | 1 | 0.600 |