Motif 568 (n=270)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0FGR8 | ESYT2 | S821 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A6NKT7 | RGPD3 | S1614 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E9PCH4 | None | S690 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| E9PCH4 | None | S1462 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| F6TDL0 | P3R3URF-PIK3R3 | S232 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. {ECO:0000256|ARBA:ARBA00057933}. |
| H0YC42 | None | S144 | ochoa | Tumor protein D52 | None |
| O00267 | SUPT5H | S120 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00429 | DNM1L | S607 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O00443 | PIK3C2A | S59 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O00533 | CHL1 | S1127 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| O00541 | PES1 | S530 | ochoa | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| O00571 | DDX3X | S152 | ochoa|psp | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14715 | RGPD8 | S1613 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14818 | PSMA7 | S93 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O14983 | ATP2A1 | S186 | ochoa|psp | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15155 | BET1 | S69 | ochoa | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15226 | NKRF | S192 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15523 | DDX3Y | S150 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43182 | ARHGAP6 | S939 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43399 | TPD52L2 | S134 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43426 | SYNJ1 | S1225 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43707 | ACTN4 | S642 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43865 | AHCYL1 | S29 | ochoa | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}. |
| O43934 | MFSD11 | S204 | ochoa | UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) | None |
| O60271 | SPAG9 | S1262 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60281 | ZNF292 | S1462 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60565 | GREM1 | S137 | ochoa | Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}. |
| O60749 | SNX2 | S227 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75369 | FLNB | S2126 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75469 | NR1I2 | S221 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O94804 | STK10 | S514 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O95235 | KIF20A | S238 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95359 | TACC2 | S2614 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95398 | RAPGEF3 | S267 | ochoa | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}. |
| O95793 | STAU1 | S390 | ochoa | Double-stranded RNA-binding protein Staufen homolog 1 | Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}. |
| O95980 | RECK | S621 | ochoa | Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) | Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). {ECO:0000250|UniProtKB:Q9Z0J1, ECO:0000269|PubMed:18194466, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:9789069}. |
| O96028 | NSD2 | S518 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P04899 | GNAI2 | S302 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P06493 | CDK1 | S233 | ochoa | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P07900 | HSP90AA1 | S476 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07947 | YES1 | S111 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P0DJD0 | RGPD1 | S1598 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1606 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DPH7 | TUBA3C | S158 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S158 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11055 | MYH3 | S1477 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11532 | DMD | S2993 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P12882 | MYH1 | S1480 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P13010 | XRCC5 | S175 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13535 | MYH8 | S1479 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14625 | HSP90B1 | S403 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P14625 | HSP90B1 | S501 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P16615 | ATP2A2 | S186 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P18583 | SON | S2190 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P25685 | DNAJB1 | S177 | ochoa | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P26358 | DNMT1 | S387 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P29401 | TKT | S276 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29590 | PML | S469 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30101 | PDIA3 | S424 | ochoa | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| P30622 | CLIP1 | S204 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P30622 | CLIP1 | S1371 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31946 | YWHAB | S136 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31949 | S100A11 | S41 | ochoa | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P35573 | AGL | S582 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35754 | GLRX | S34 | ochoa | Glutaredoxin-1 (Thioltransferase-1) (TTase-1) | Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. |
| P36896 | ACVR1B | S168 | ochoa | Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269|PubMed:12364468, ECO:0000269|PubMed:12639945, ECO:0000269|PubMed:18039968, ECO:0000269|PubMed:20226172, ECO:0000269|PubMed:8196624, ECO:0000269|PubMed:9032295, ECO:0000269|PubMed:9892009}. |
| P37275 | ZEB1 | S342 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P37802 | TAGLN2 | S94 | ochoa | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P38936 | CDKN1A | S31 | ochoa | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P42680 | TEC | S521 | ochoa | Tyrosine-protein kinase Tec (EC 2.7.10.2) | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}. |
| P46100 | ATRX | S313 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46108 | CRK | S119 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P48742 | LHX1 | S168 | ochoa | LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) | Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}. |
| P48764 | SLC9A3 | S592 | ochoa | Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) | Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773). {ECO:0000250|UniProtKB:G3X939, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:24622516, ECO:0000269|PubMed:26358773, ECO:0000269|PubMed:35613257}. |
| P49792 | RANBP2 | S1496 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2589 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51153 | RAB13 | S111 | ochoa|psp | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P51798 | CLCN7 | S632 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P51948 | MNAT1 | S189 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P52179 | MYOM1 | S236 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52701 | MSH6 | S274 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P52757 | CHN2 | S167 | psp | Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| P54296 | MYOM2 | S1042 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54296 | MYOM2 | S1392 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55082 | MFAP3 | S326 | ochoa | Microfibril-associated glycoprotein 3 | Component of the elastin-associated microfibrils. |
| P55884 | EIF3B | S453 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P61006 | RAB8A | S111 | ochoa|psp | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}. |
| P62851 | RPS25 | S93 | ochoa | Small ribosomal subunit protein eS25 (40S ribosomal protein S25) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P68363 | TUBA1B | S158 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S158 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78527 | PRKDC | S2998 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78527 | PRKDC | S3010 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P79483 | HLA-DRB3 | S208 | ochoa | HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3) | A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:16148104, PubMed:19531622, PubMed:19830726, PubMed:20368442, PubMed:22929521, PubMed:23569328, PubMed:2463305, PubMed:2788702, PubMed:30282837, PubMed:31020640, PubMed:31308093, PubMed:31333679). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity). {ECO:0000250|UniProtKB:P01911, ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2463305, PubMed:2788702). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:31020640}.; FUNCTION: ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:23569328, PubMed:31308093). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M.tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104). {ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:32341563}. |
| Q00325 | SLC25A3 | S297 | ochoa | Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) | Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250|UniProtKB:P12234, ECO:0000250|UniProtKB:P16036, ECO:0000269|PubMed:17273968, ECO:0000269|PubMed:29237729}. |
| Q00987 | MDM2 | S395 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01082 | SPTBN1 | S257 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01484 | ANK2 | S3765 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02487 | DSC2 | S828 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02880 | TOP2B | S1279 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q03188 | CENPC | S46 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06187 | BTK | S553 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08050 | FOXM1 | S567 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08170 | SRSF4 | S112 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08881 | ITK | S514 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q09666 | AHNAK | S148 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12834 | CDC20 | S92 | ochoa|psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12931 | TRAP1 | S195 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13007 | IL24 | S161 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13029 | PRDM2 | S464 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13127 | REST | S856 | ochoa | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13151 | HNRNPA0 | S119 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13243 | SRSF5 | S116 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13247 | SRSF6 | S118 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13315 | ATM | S1270 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13315 | ATM | S1981 | ochoa|psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13416 | ORC2 | S228 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13596 | SNX1 | S230 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13813 | SPTAN1 | S1041 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13905 | RAPGEF1 | S562 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14315 | FLNC | S2461 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14684 | RRP1B | S160 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14684 | RRP1B | S339 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14789 | GOLGB1 | S1258 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14980 | NUMA1 | S1278 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15024 | EXOSC7 | S177 | ochoa | Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Q15139 | PRKD1 | S473 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15303 | ERBB4 | S1124 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15424 | SAFB | S587 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15554 | TERF2 | S410 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q16821 | PPP1R3A | S266 | ochoa | Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}. |
| Q16851 | UGP2 | S320 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q27J81 | INF2 | S1147 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2KHR3 | QSER1 | S974 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2KHR3 | QSER1 | S991 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q3MII6 | TBC1D25 | S156 | ochoa | TBC1 domain family member 25 | Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}. |
| Q3SXY8 | ARL13B | S148 | ochoa | ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (PubMed:38219074). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (PubMed:23223633). {ECO:0000269|PubMed:23150559, ECO:0000269|PubMed:23223633, ECO:0000269|PubMed:38219074}. |
| Q4LE39 | ARID4B | S1256 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4VC05 | BCL7A | S154 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q53F19 | NCBP3 | S575 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q53S48 | STON1-GTF2A1L | S1023 | ochoa | Stonin-1 (Stoned B-like factor) | May be involved in the endocytic machinery. {ECO:0000256|ARBA:ARBA00059680}. |
| Q58FF3 | HSP90B2P | S60 | ochoa | Putative endoplasmin-like protein (Putative heat shock protein 90 kDa beta member 2) | Putative molecular chaperone. {ECO:0000250}. |
| Q58FF3 | HSP90B2P | S158 | ochoa | Putative endoplasmin-like protein (Putative heat shock protein 90 kDa beta member 2) | Putative molecular chaperone. {ECO:0000250}. |
| Q5F1R6 | DNAJC21 | S436 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5R372 | RABGAP1L | S128 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SW79 | CEP170 | S654 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TB80 | CEP162 | S157 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q5UIP0 | RIF1 | S1564 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUA4 | ZNF318 | S501 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q6P0N0 | MIS18BP1 | S19 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6VMQ6 | ATF7IP | S310 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6VMQ6 | ATF7IP | S926 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZS30 | NBEAL1 | S1349 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q71F23 | CENPU | S206 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71U36 | TUBA1A | S158 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q76FK4 | NOL8 | S378 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L0J3 | SV2A | S411 | psp | Synaptic vesicle glycoprotein 2A | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}. |
| Q7Z3J3 | RGPD4 | S1614 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6Z7 | HUWE1 | S2388 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TC9 | MYPN | S197 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86UT8 | CENATAC | S182 | ochoa | Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) | Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype (PubMed:34009673). Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). {ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34009673}. |
| Q86XZ4 | SPATS2 | S120 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IYA6 | CKAP2L | S109 | ochoa | Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis) | Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. {ECO:0000269|PubMed:25439729}. |
| Q8IZE3 | SCYL3 | S569 | ochoa | Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) | May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}. |
| Q8N302 | AGGF1 | S351 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4C6 | NIN | S1538 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5C8 | TAB3 | S126 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NC44 | RETREG2 | S316 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NHV4 | NEDD1 | S389 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI08 | NCOA7 | S441 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TEU7 | RAPGEF6 | S640 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEU7 | RAPGEF6 | S1412 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WVC0 | LEO1 | S151 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WW38 | ZFPM2 | S586 | ochoa | Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. |
| Q8WXX7 | AUTS2 | S261 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92569 | PIK3R3 | S186 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| Q92610 | ZNF592 | S1227 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92794 | KAT6A | S892 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92794 | KAT6A | S893 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92973 | TNPO1 | S32 | ochoa | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q92997 | DVL3 | S61 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q92997 | DVL3 | S311 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96CC6 | RHBDF1 | S346 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96FV9 | THOC1 | S560 | ochoa | THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96GN5 | CDCA7L | S237 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96Q89 | KIF20B | S1586 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RS6 | NUDCD1 | S270 | ochoa | NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) | None |
| Q99666 | RGPD5 | S1613 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQE3 | TUBA1C | S158 | ochoa|psp | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BX66 | SORBS1 | S108 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXW9 | FANCD2 | S126 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BXW9 | FANCD2 | T608 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BY89 | KIAA1671 | S1387 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C010 | PKIB | S53 | ochoa | cAMP-dependent protein kinase inhibitor beta (PKI-beta) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}. |
| Q9C026 | TRIM9 | S76 | psp | E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}. |
| Q9GZU2 | PEG3 | S222 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9H2P0 | ADNP | S874 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4Z3 | PCIF1 | S121 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H582 | ZNF644 | S1138 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6A9 | PCNX3 | S171 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H7N4 | SCAF1 | S846 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HCK1 | ZDBF2 | S1574 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NQ75 | CASS4 | S311 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQ75 | CASS4 | S328 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NR48 | ASH1L | S2951 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NS68 | TNFRSF19 | S387 | ochoa | Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) | Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. |
| Q9NWQ8 | PAG1 | S229 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NX24 | NHP2 | S19 | ochoa | H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}. |
| Q9NZU5 | LMCD1 | S42 | ochoa | LIM and cysteine-rich domains protein 1 (Dyxin) | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}. |
| Q9NZV7 | ZIM2 | S97 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9P0K7 | RAI14 | S479 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P219 | CCDC88C | S951 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2W9 | STX18 | S187 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UHB6 | LIMA1 | S704 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UKS6 | PACSIN3 | S303 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9UKV3 | ACIN1 | S132 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1482 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1480 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULJ3 | ZBTB21 | S739 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULU4 | ZMYND8 | S1102 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULW0 | TPX2 | S322 | psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULW0 | TPX2 | S646 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UNF0 | PACSIN2 | S305 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UNN4 | GTF2A1L | S319 | ochoa | TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}. |
| Q9UNZ2 | NSFL1C | S165 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPM8 | AP4E1 | S700 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPM8 | AP4E1 | S868 | psp | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPT8 | ZC3H4 | S815 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPV0 | CEP164 | S1205 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPV9 | TRAK1 | S393 | ochoa | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}. |
| Q9Y485 | DMXL1 | S682 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y490 | TLN1 | S446 | ochoa|psp | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S428 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y4X4 | KLF12 | S42 | ochoa | Krueppel-like factor 12 (Transcriptional repressor AP-2rep) | Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. |
| Q9Y623 | MYH4 | S1480 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y657 | SPIN1 | S109 | psp | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q9Y666 | SLC12A7 | S62 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y678 | COPG1 | S246 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| Q9Y6D5 | ARFGEF2 | S1498 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q96RT7 | TUBGCP6 | S1176 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P00338 | LDHA | S105 | Sugiyama | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P07195 | LDHB | S106 | Sugiyama | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P05556 | ITGB1 | S509 | Sugiyama | Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). {ECO:0000250|UniProtKB:P07228, ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.; FUNCTION: (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760). {ECO:0000269|PubMed:32487760}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis. {ECO:0000305|PubMed:21471204}.; FUNCTION: (Microbial infection) Facilitates rabies infection in a fibronectin-dependent manner and participates in rabies virus traffic after internalization. {ECO:0000269|PubMed:31666383}. |
| P08238 | HSP90AB1 | S474 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| O15111 | CHUK | S249 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P52597 | HNRNPF | S63 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P07947 | YES1 | S133 | Sugiyama | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P14625 | HSP90B1 | S256 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P08684 | CYP3A4 | S100 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| Q01518 | CAP1 | S431 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q5SW79 | CEP170 | S223 | Sugiyama | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q96PZ0 | PUS7 | S135 | Sugiyama | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| P29320 | EPHA3 | S939 | Sugiyama | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P42681 | TXK | S422 | Sugiyama | Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) | Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}. |
| P30101 | PDIA3 | S169 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| Q15181 | PPA1 | S127 | Sugiyama | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| Q9P032 | NDUFAF4 | S45 | Sugiyama | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882, ECO:0000269|PubMed:28853723}. |
| P51813 | BMX | S568 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| O60610 | DIAPH1 | S793 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| Q01973 | ROR1 | S642 | Sugiyama | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350, ECO:0000269|PubMed:36949068}. |
| Q02763 | TEK | S862 | Sugiyama | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) | Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}. |
| Q13882 | PTK6 | S28 | Sugiyama | Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. {ECO:0000269|PubMed:20554524}.; FUNCTION: [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
| P13073 | COX4I1 | S34 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P08174 | CD55 | S78 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q8IY84 | NIM1K | S124 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q8NE71 | ABCF1 | S293 | Sugiyama | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}. |
| Q04726 | TLE3 | S743 | Sugiyama | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q8NFH4 | NUP37 | S142 | Sugiyama | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900, ECO:0000269|PubMed:30179222}. |
| Q92900 | UPF1 | S274 | Sugiyama | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96PE3 | INPP4A | S788 | Sugiyama | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q9UKI8 | TLK1 | S54 | Sugiyama | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 9.409866e-10 | 9.026 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.896946e-08 | 7.722 |
| R-HSA-69275 | G2/M Transition | 1.407277e-08 | 7.852 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.637828e-08 | 7.786 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.069945e-07 | 6.971 |
| R-HSA-68877 | Mitotic Prometaphase | 1.231853e-07 | 6.909 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.942765e-07 | 6.712 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.557714e-07 | 6.449 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.969299e-06 | 5.706 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.846812e-06 | 5.734 |
| R-HSA-9646399 | Aggrephagy | 3.323273e-06 | 5.478 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.424675e-06 | 5.465 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.171179e-06 | 5.499 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.114593e-06 | 5.386 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.290491e-06 | 5.277 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 8.461574e-06 | 5.073 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.340338e-05 | 4.631 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.405239e-05 | 4.619 |
| R-HSA-68886 | M Phase | 2.380136e-05 | 4.623 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 3.809004e-05 | 4.419 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.668772e-05 | 4.435 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.189302e-05 | 4.378 |
| R-HSA-5617833 | Cilium Assembly | 4.246059e-05 | 4.372 |
| R-HSA-68882 | Mitotic Anaphase | 4.101584e-05 | 4.387 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.299637e-05 | 4.367 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.665009e-05 | 4.331 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.538261e-05 | 4.343 |
| R-HSA-373760 | L1CAM interactions | 3.689188e-05 | 4.433 |
| R-HSA-983189 | Kinesins | 4.583521e-05 | 4.339 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.400850e-05 | 4.131 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.275650e-05 | 4.138 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.636126e-05 | 4.117 |
| R-HSA-438064 | Post NMDA receptor activation events | 8.748000e-05 | 4.058 |
| R-HSA-5620924 | Intraflagellar transport | 9.437368e-05 | 4.025 |
| R-HSA-9663891 | Selective autophagy | 9.452209e-05 | 4.024 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 9.844584e-05 | 4.007 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.150735e-04 | 3.939 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.279731e-04 | 3.893 |
| R-HSA-190861 | Gap junction assembly | 1.289020e-04 | 3.890 |
| R-HSA-199991 | Membrane Trafficking | 1.336920e-04 | 3.874 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.792699e-04 | 3.746 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.931063e-04 | 3.714 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 2.039745e-04 | 3.690 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 2.039745e-04 | 3.690 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.245931e-04 | 3.649 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.261669e-04 | 3.646 |
| R-HSA-9833482 | PKR-mediated signaling | 2.634497e-04 | 3.579 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.899766e-04 | 3.538 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.050467e-04 | 3.516 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.121170e-04 | 3.506 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.325094e-04 | 3.478 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 3.773587e-04 | 3.423 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.092711e-04 | 3.388 |
| R-HSA-190828 | Gap junction trafficking | 4.537685e-04 | 3.343 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 4.617908e-04 | 3.336 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.025185e-04 | 3.299 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.691009e-04 | 3.245 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.070114e-04 | 3.217 |
| R-HSA-437239 | Recycling pathway of L1 | 6.070114e-04 | 3.217 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 7.296004e-04 | 3.137 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 7.296004e-04 | 3.137 |
| R-HSA-157858 | Gap junction trafficking and regulation | 7.296004e-04 | 3.137 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.748302e-04 | 3.111 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.492161e-04 | 3.071 |
| R-HSA-380287 | Centrosome maturation | 9.767507e-04 | 3.010 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.124080e-03 | 2.949 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.094371e-03 | 2.961 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.082528e-03 | 2.966 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.096836e-03 | 2.960 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.174592e-03 | 2.930 |
| R-HSA-9612973 | Autophagy | 1.634298e-03 | 2.787 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.748255e-03 | 2.757 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.815773e-03 | 2.741 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.815773e-03 | 2.741 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.204670e-03 | 2.657 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.204670e-03 | 2.657 |
| R-HSA-8848021 | Signaling by PTK6 | 2.204670e-03 | 2.657 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.204670e-03 | 2.657 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.204670e-03 | 2.657 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.214647e-03 | 2.655 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.452430e-03 | 2.610 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.506796e-03 | 2.601 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.758320e-03 | 2.559 |
| R-HSA-1632852 | Macroautophagy | 2.917487e-03 | 2.535 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.085600e-03 | 2.511 |
| R-HSA-391251 | Protein folding | 3.087718e-03 | 2.510 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 3.379000e-03 | 2.471 |
| R-HSA-2262752 | Cellular responses to stress | 3.166272e-03 | 2.499 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.961664e-03 | 2.402 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.044211e-03 | 2.393 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.180582e-03 | 2.379 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.231322e-03 | 2.374 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.231394e-03 | 2.374 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.669314e-03 | 2.331 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.649471e-03 | 2.333 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.669314e-03 | 2.331 |
| R-HSA-422475 | Axon guidance | 4.490431e-03 | 2.348 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.862655e-03 | 2.313 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 5.434817e-03 | 2.265 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.470049e-03 | 2.262 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.636341e-03 | 2.249 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.163403e-03 | 2.210 |
| R-HSA-169893 | Prolonged ERK activation events | 6.254467e-03 | 2.204 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 6.254467e-03 | 2.204 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 7.143973e-03 | 2.146 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.871746e-03 | 2.163 |
| R-HSA-9609690 | HCMV Early Events | 7.100893e-03 | 2.149 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 7.143973e-03 | 2.146 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.466248e-03 | 2.127 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 7.579768e-03 | 2.120 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 8.401329e-03 | 2.076 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 8.401329e-03 | 2.076 |
| R-HSA-913531 | Interferon Signaling | 8.591763e-03 | 2.066 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.606981e-03 | 2.065 |
| R-HSA-9682385 | FLT3 signaling in disease | 8.606981e-03 | 2.065 |
| R-HSA-176417 | Phosphorylation of Emi1 | 9.781665e-03 | 2.010 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.137872e-03 | 2.039 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 9.781665e-03 | 2.010 |
| R-HSA-9675108 | Nervous system development | 8.724957e-03 | 2.059 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.005238e-02 | 1.998 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.080468e-02 | 1.966 |
| R-HSA-373753 | Nephrin family interactions | 1.142571e-02 | 1.942 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.161043e-02 | 1.935 |
| R-HSA-3371568 | Attenuation phase | 1.161043e-02 | 1.935 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.223204e-02 | 1.913 |
| R-HSA-9830369 | Kidney development | 1.319494e-02 | 1.880 |
| R-HSA-3371556 | Cellular response to heat stress | 1.328066e-02 | 1.877 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.401453e-02 | 1.853 |
| R-HSA-109582 | Hemostasis | 1.451686e-02 | 1.838 |
| R-HSA-447041 | CHL1 interactions | 1.492116e-02 | 1.826 |
| R-HSA-8849473 | PTK6 Expression | 1.492116e-02 | 1.826 |
| R-HSA-69206 | G1/S Transition | 1.588049e-02 | 1.799 |
| R-HSA-9830674 | Formation of the ureteric bud | 1.690936e-02 | 1.772 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.492116e-02 | 1.826 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.690936e-02 | 1.772 |
| R-HSA-449147 | Signaling by Interleukins | 1.720889e-02 | 1.764 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.725487e-02 | 1.763 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.767432e-02 | 1.753 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.830538e-02 | 1.737 |
| R-HSA-75153 | Apoptotic execution phase | 1.833497e-02 | 1.737 |
| R-HSA-9620244 | Long-term potentiation | 2.011347e-02 | 1.697 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.061960e-02 | 1.686 |
| R-HSA-74160 | Gene expression (Transcription) | 2.068269e-02 | 1.684 |
| R-HSA-170984 | ARMS-mediated activation | 2.097815e-02 | 1.678 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 2.097815e-02 | 1.678 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.432788e-02 | 1.614 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.362843e-02 | 1.627 |
| R-HSA-72187 | mRNA 3'-end processing | 2.569390e-02 | 1.590 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.706945e-02 | 1.568 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.436142e-02 | 1.613 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 2.432788e-02 | 1.614 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.432788e-02 | 1.614 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.665809e-02 | 1.574 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.581525e-02 | 1.588 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.660014e-02 | 1.575 |
| R-HSA-9609646 | HCMV Infection | 2.931515e-02 | 1.533 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.948356e-02 | 1.530 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 3.162645e-02 | 1.500 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 3.162645e-02 | 1.500 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 3.162645e-02 | 1.500 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 3.162645e-02 | 1.500 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.347042e-02 | 1.475 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.377315e-02 | 1.471 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.393894e-02 | 1.469 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.609797e-02 | 1.443 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.609797e-02 | 1.443 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.609797e-02 | 1.443 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.609797e-02 | 1.443 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.609797e-02 | 1.443 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 3.609797e-02 | 1.443 |
| R-HSA-390522 | Striated Muscle Contraction | 3.836826e-02 | 1.416 |
| R-HSA-73886 | Chromosome Maintenance | 4.010418e-02 | 1.397 |
| R-HSA-354192 | Integrin signaling | 3.603275e-02 | 1.443 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.141543e-02 | 1.383 |
| R-HSA-170968 | Frs2-mediated activation | 3.966874e-02 | 1.402 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.966874e-02 | 1.402 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.964534e-02 | 1.402 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.662852e-02 | 1.436 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 3.966874e-02 | 1.402 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.731189e-02 | 1.428 |
| R-HSA-373755 | Semaphorin interactions | 4.322969e-02 | 1.364 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.326479e-02 | 1.364 |
| R-HSA-187687 | Signalling to ERKs | 4.326479e-02 | 1.364 |
| R-HSA-3371511 | HSF1 activation | 4.582455e-02 | 1.339 |
| R-HSA-168256 | Immune System | 4.605276e-02 | 1.337 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.699058e-02 | 1.328 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.815179e-02 | 1.317 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 4.839194e-02 | 1.315 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 4.839194e-02 | 1.315 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.839194e-02 | 1.315 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 4.839194e-02 | 1.315 |
| R-HSA-69481 | G2/M Checkpoints | 4.900553e-02 | 1.310 |
| R-HSA-8875878 | MET promotes cell motility | 5.116348e-02 | 1.291 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 5.299022e-02 | 1.276 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.365695e-02 | 1.270 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.365695e-02 | 1.270 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 6.262468e-02 | 1.203 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.607945e-02 | 1.180 |
| R-HSA-69541 | Stabilization of p53 | 5.394109e-02 | 1.268 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.153450e-02 | 1.211 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 5.365695e-02 | 1.270 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 5.365695e-02 | 1.270 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.716145e-02 | 1.243 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.922190e-02 | 1.228 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.607945e-02 | 1.180 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.153450e-02 | 1.211 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.153450e-02 | 1.211 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.970835e-02 | 1.224 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 6.262468e-02 | 1.203 |
| R-HSA-397014 | Muscle contraction | 6.704680e-02 | 1.174 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.480859e-02 | 1.261 |
| R-HSA-1483255 | PI Metabolism | 5.922190e-02 | 1.228 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 5.773676e-02 | 1.239 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.454389e-02 | 1.263 |
| R-HSA-9831926 | Nephron development | 6.764729e-02 | 1.170 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 6.764729e-02 | 1.170 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 6.764729e-02 | 1.170 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.784667e-02 | 1.168 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.835633e-02 | 1.165 |
| R-HSA-1433557 | Signaling by SCF-KIT | 6.887542e-02 | 1.162 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.941205e-02 | 1.159 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 7.089712e-02 | 1.149 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 7.089712e-02 | 1.149 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 7.089712e-02 | 1.149 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 7.089712e-02 | 1.149 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 7.089712e-02 | 1.149 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 7.089712e-02 | 1.149 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 7.089712e-02 | 1.149 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 7.089712e-02 | 1.149 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 7.089712e-02 | 1.149 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 7.089712e-02 | 1.149 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 7.089712e-02 | 1.149 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 7.089712e-02 | 1.149 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 7.206480e-02 | 1.142 |
| R-HSA-69231 | Cyclin D associated events in G1 | 7.206480e-02 | 1.142 |
| R-HSA-69236 | G1 Phase | 7.206480e-02 | 1.142 |
| R-HSA-212436 | Generic Transcription Pathway | 7.242331e-02 | 1.140 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 7.279810e-02 | 1.138 |
| R-HSA-392517 | Rap1 signalling | 7.279810e-02 | 1.138 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 7.279810e-02 | 1.138 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 7.279810e-02 | 1.138 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 7.279810e-02 | 1.138 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 7.531928e-02 | 1.123 |
| R-HSA-774815 | Nucleosome assembly | 7.531928e-02 | 1.123 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 7.531928e-02 | 1.123 |
| R-HSA-202403 | TCR signaling | 7.643094e-02 | 1.117 |
| R-HSA-8849472 | PTK6 Down-Regulation | 1.207620e-01 | 0.918 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 1.367836e-01 | 0.864 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.525143e-01 | 0.817 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.525143e-01 | 0.817 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.679592e-01 | 0.775 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.831236e-01 | 0.737 |
| R-HSA-8875656 | MET receptor recycling | 1.831236e-01 | 0.737 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.831236e-01 | 0.737 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.980125e-01 | 0.703 |
| R-HSA-164843 | 2-LTR circle formation | 2.126309e-01 | 0.672 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.126309e-01 | 0.672 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 9.456010e-02 | 1.024 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.002611e-01 | 0.999 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.002611e-01 | 0.999 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.549120e-01 | 0.594 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.300595e-01 | 0.886 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.684966e-01 | 0.571 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.362434e-01 | 0.866 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.424911e-01 | 0.846 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.487983e-01 | 0.827 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.487983e-01 | 0.827 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.949298e-01 | 0.530 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.949298e-01 | 0.530 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.949298e-01 | 0.530 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.615746e-01 | 0.792 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.615746e-01 | 0.792 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9.982985e-02 | 1.001 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 9.982985e-02 | 1.001 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.680357e-01 | 0.775 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.077872e-01 | 0.512 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.035644e-01 | 0.985 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.035644e-01 | 0.985 |
| R-HSA-72649 | Translation initiation complex formation | 1.073535e-01 | 0.969 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.111961e-01 | 0.954 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.810843e-01 | 0.742 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.150908e-01 | 0.939 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.075882e-01 | 0.683 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.142795e-01 | 0.669 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.142795e-01 | 0.669 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.142795e-01 | 0.669 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.615176e-01 | 0.582 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.682912e-01 | 0.571 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.150908e-01 | 0.939 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.882877e-01 | 0.725 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.300595e-01 | 0.886 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.831236e-01 | 0.737 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.142795e-01 | 0.669 |
| R-HSA-167169 | HIV Transcription Elongation | 2.142795e-01 | 0.669 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 1.207620e-01 | 0.918 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.239441e-01 | 0.907 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.277187e-01 | 0.643 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.615176e-01 | 0.582 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.615176e-01 | 0.582 |
| R-HSA-9664873 | Pexophagy | 2.126309e-01 | 0.672 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 9.456010e-02 | 1.024 |
| R-HSA-72086 | mRNA Capping | 1.362434e-01 | 0.866 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.300595e-01 | 0.886 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.075882e-01 | 0.683 |
| R-HSA-6798695 | Neutrophil degranulation | 1.059686e-01 | 0.975 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.405086e-02 | 1.027 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.615176e-01 | 0.582 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.239441e-01 | 0.907 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.949298e-01 | 0.530 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.789081e-01 | 0.747 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.789081e-01 | 0.747 |
| R-HSA-4641265 | Repression of WNT target genes | 2.549120e-01 | 0.594 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.394835e-01 | 0.855 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.926695e-01 | 0.715 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.085504e-01 | 0.681 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.525143e-01 | 0.817 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.679592e-01 | 0.775 |
| R-HSA-9664420 | Killing mechanisms | 3.077872e-01 | 0.512 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 3.077872e-01 | 0.512 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.942776e-01 | 0.712 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.209906e-01 | 0.656 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.277187e-01 | 0.643 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.344609e-01 | 0.630 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.547454e-01 | 0.594 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.682912e-01 | 0.571 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.367836e-01 | 0.864 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 1.367836e-01 | 0.864 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 1.525143e-01 | 0.817 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 1.525143e-01 | 0.817 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.980125e-01 | 0.703 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.179016e-01 | 0.928 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.551609e-01 | 0.809 |
| R-HSA-9930044 | Nuclear RNA decay | 1.615746e-01 | 0.792 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.682912e-01 | 0.571 |
| R-HSA-4641258 | Degradation of DVL | 1.942776e-01 | 0.712 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.789081e-01 | 0.747 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 1.207620e-01 | 0.918 |
| R-HSA-9864848 | Complex IV assembly | 2.953548e-01 | 0.530 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.077872e-01 | 0.512 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.148904e-02 | 1.039 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.810843e-01 | 0.742 |
| R-HSA-8875513 | MET interacts with TNS proteins | 8.782426e-02 | 1.056 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.367836e-01 | 0.864 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.367836e-01 | 0.864 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.831236e-01 | 0.737 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.126309e-01 | 0.672 |
| R-HSA-192905 | vRNP Assembly | 2.269838e-01 | 0.644 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.549120e-01 | 0.594 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.684966e-01 | 0.571 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.684966e-01 | 0.571 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.684966e-01 | 0.571 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.949298e-01 | 0.530 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.949298e-01 | 0.530 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.077872e-01 | 0.512 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.942776e-01 | 0.712 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.547454e-01 | 0.594 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.021025e-01 | 0.520 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.993591e-01 | 0.524 |
| R-HSA-9830364 | Formation of the nephric duct | 1.119370e-01 | 0.951 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.083444e-01 | 0.965 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.142795e-01 | 0.669 |
| R-HSA-5260271 | Diseases of Immune System | 2.142795e-01 | 0.669 |
| R-HSA-162587 | HIV Life Cycle | 2.216149e-01 | 0.654 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.980125e-01 | 0.703 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.239441e-01 | 0.907 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.818344e-01 | 0.550 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.949298e-01 | 0.530 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.680357e-01 | 0.775 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.745401e-01 | 0.758 |
| R-HSA-9766229 | Degradation of CDH1 | 2.818335e-01 | 0.550 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.953548e-01 | 0.530 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.190364e-01 | 0.924 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.818344e-01 | 0.550 |
| R-HSA-4086400 | PCP/CE pathway | 2.114081e-01 | 0.675 |
| R-HSA-73894 | DNA Repair | 2.673673e-01 | 0.573 |
| R-HSA-9669938 | Signaling by KIT in disease | 9.456010e-02 | 1.024 |
| R-HSA-162906 | HIV Infection | 3.033484e-01 | 0.518 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 8.782426e-02 | 1.056 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 1.207620e-01 | 0.918 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.980125e-01 | 0.703 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.410759e-01 | 0.618 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 7.863780e-02 | 1.104 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.949298e-01 | 0.530 |
| R-HSA-9754706 | Atorvastatin ADME | 3.077872e-01 | 0.512 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.230316e-01 | 0.910 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.142795e-01 | 0.669 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.209231e-01 | 0.656 |
| R-HSA-8953854 | Metabolism of RNA | 1.114032e-01 | 0.953 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.194665e-01 | 0.923 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.363302e-01 | 0.865 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 1.487983e-01 | 0.827 |
| R-HSA-1502540 | Signaling by Activin | 2.949298e-01 | 0.530 |
| R-HSA-68875 | Mitotic Prophase | 2.340969e-01 | 0.631 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.549120e-01 | 0.594 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.615746e-01 | 0.792 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.745401e-01 | 0.758 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.812019e-01 | 0.742 |
| R-HSA-1280218 | Adaptive Immune System | 8.836826e-02 | 1.054 |
| R-HSA-114608 | Platelet degranulation | 1.231450e-01 | 0.910 |
| R-HSA-69242 | S Phase | 1.925955e-01 | 0.715 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.525143e-01 | 0.817 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.679592e-01 | 0.775 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.679592e-01 | 0.775 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.679592e-01 | 0.775 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.831236e-01 | 0.737 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.980125e-01 | 0.703 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 2.126309e-01 | 0.672 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.410759e-01 | 0.618 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.410759e-01 | 0.618 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.549120e-01 | 0.594 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.549120e-01 | 0.594 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.549120e-01 | 0.594 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.818344e-01 | 0.550 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.142795e-01 | 0.669 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.142795e-01 | 0.669 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.209906e-01 | 0.656 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.021025e-01 | 0.520 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.680406e-01 | 0.775 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.574779e-02 | 1.019 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.910909e-02 | 1.102 |
| R-HSA-1566948 | Elastic fibre formation | 2.009199e-01 | 0.697 |
| R-HSA-202433 | Generation of second messenger molecules | 2.142795e-01 | 0.669 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.119370e-01 | 0.951 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.980125e-01 | 0.703 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.745401e-01 | 0.758 |
| R-HSA-162592 | Integration of provirus | 2.410759e-01 | 0.618 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 1.179016e-01 | 0.928 |
| R-HSA-8854214 | TBC/RABGAPs | 2.412145e-01 | 0.618 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.420388e-01 | 0.848 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.973147e-01 | 0.705 |
| R-HSA-2559583 | Cellular Senescence | 3.042640e-01 | 0.517 |
| R-HSA-202424 | Downstream TCR signaling | 2.745324e-01 | 0.561 |
| R-HSA-9675135 | Diseases of DNA repair | 2.615176e-01 | 0.582 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.353518e-01 | 0.628 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 2.126309e-01 | 0.672 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.269838e-01 | 0.644 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.269838e-01 | 0.644 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.269838e-01 | 0.644 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.818344e-01 | 0.550 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.818344e-01 | 0.550 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.949298e-01 | 0.530 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.949298e-01 | 0.530 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.077872e-01 | 0.512 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.009199e-01 | 0.697 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.615176e-01 | 0.582 |
| R-HSA-9634597 | GPER1 signaling | 2.750639e-01 | 0.561 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 9.982985e-02 | 1.001 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.548341e-01 | 0.594 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.958983e-01 | 0.708 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.949298e-01 | 0.530 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.928578e-01 | 0.715 |
| R-HSA-9658195 | Leishmania infection | 1.928578e-01 | 0.715 |
| R-HSA-5578775 | Ion homeostasis | 1.150908e-01 | 0.939 |
| R-HSA-6806834 | Signaling by MET | 2.209231e-01 | 0.656 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.479741e-01 | 0.830 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.367836e-01 | 0.864 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.684966e-01 | 0.571 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.818344e-01 | 0.550 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.818344e-01 | 0.550 |
| R-HSA-9845576 | Glycosphingolipid transport | 1.876646e-01 | 0.727 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.075882e-01 | 0.683 |
| R-HSA-8939211 | ESR-mediated signaling | 1.972711e-01 | 0.705 |
| R-HSA-4839726 | Chromatin organization | 2.284777e-01 | 0.641 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.750639e-01 | 0.561 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.698652e-01 | 0.569 |
| R-HSA-9659379 | Sensory processing of sound | 2.161544e-01 | 0.665 |
| R-HSA-162582 | Signal Transduction | 1.062973e-01 | 0.973 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.709711e-02 | 1.113 |
| R-HSA-597592 | Post-translational protein modification | 3.026904e-01 | 0.519 |
| R-HSA-210990 | PECAM1 interactions | 2.269838e-01 | 0.644 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.949298e-01 | 0.530 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.654341e-01 | 0.781 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.353518e-01 | 0.628 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.988304e-02 | 1.046 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.396062e-01 | 0.855 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.684966e-01 | 0.571 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.362434e-01 | 0.866 |
| R-HSA-186763 | Downstream signal transduction | 1.487983e-01 | 0.827 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.077872e-01 | 0.512 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.973147e-01 | 0.705 |
| R-HSA-1266738 | Developmental Biology | 2.727467e-01 | 0.564 |
| R-HSA-416700 | Other semaphorin interactions | 2.949298e-01 | 0.530 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.199040e-02 | 1.036 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.533689e-01 | 0.814 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.297774e-01 | 0.887 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.980125e-01 | 0.703 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 8.895765e-02 | 1.051 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.450617e-01 | 0.611 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.007311e-01 | 0.997 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.043419e-01 | 0.517 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 9.982985e-02 | 1.001 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.338021e-01 | 0.874 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.060551e-01 | 0.974 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.743832e-01 | 0.758 |
| R-HSA-8982491 | Glycogen metabolism | 2.142795e-01 | 0.669 |
| R-HSA-1500931 | Cell-Cell communication | 2.793800e-01 | 0.554 |
| R-HSA-1538133 | G0 and Early G1 | 1.551609e-01 | 0.809 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.876646e-01 | 0.727 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.462518e-01 | 0.835 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.479768e-01 | 0.606 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 3.077872e-01 | 0.512 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.745401e-01 | 0.758 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.809452e-01 | 0.551 |
| R-HSA-109581 | Apoptosis | 1.170206e-01 | 0.932 |
| R-HSA-5357801 | Programmed Cell Death | 1.238448e-01 | 0.907 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.001772e-01 | 0.523 |
| R-HSA-112316 | Neuronal System | 2.907945e-01 | 0.536 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.965510e-02 | 1.002 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.173623e-01 | 0.930 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.075882e-01 | 0.683 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.088390e-01 | 0.510 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.088390e-01 | 0.510 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.093284e-01 | 0.510 |
| R-HSA-163685 | Integration of energy metabolism | 3.106198e-01 | 0.508 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.149567e-01 | 0.502 |
| R-HSA-157579 | Telomere Maintenance | 3.193087e-01 | 0.496 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.204109e-01 | 0.494 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.204109e-01 | 0.494 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.204109e-01 | 0.494 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.204109e-01 | 0.494 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 3.204109e-01 | 0.494 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.204109e-01 | 0.494 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.204109e-01 | 0.494 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.222712e-01 | 0.492 |
| R-HSA-422356 | Regulation of insulin secretion | 3.243008e-01 | 0.489 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.257063e-01 | 0.487 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.269134e-01 | 0.486 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.271016e-01 | 0.485 |
| R-HSA-9664407 | Parasite infection | 3.271016e-01 | 0.485 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.271016e-01 | 0.485 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.289635e-01 | 0.483 |
| R-HSA-75893 | TNF signaling | 3.289635e-01 | 0.483 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.328052e-01 | 0.478 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.328052e-01 | 0.478 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.328052e-01 | 0.478 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.328052e-01 | 0.478 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.328052e-01 | 0.478 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.328052e-01 | 0.478 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.328052e-01 | 0.478 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.328052e-01 | 0.478 |
| R-HSA-2028269 | Signaling by Hippo | 3.328052e-01 | 0.478 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.356378e-01 | 0.474 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.392746e-01 | 0.469 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.392746e-01 | 0.469 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.394993e-01 | 0.469 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.422923e-01 | 0.466 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.436361e-01 | 0.464 |
| R-HSA-210993 | Tie2 Signaling | 3.449742e-01 | 0.462 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.449742e-01 | 0.462 |
| R-HSA-5358508 | Mismatch Repair | 3.449742e-01 | 0.462 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.449742e-01 | 0.462 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.449742e-01 | 0.462 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.449742e-01 | 0.462 |
| R-HSA-180292 | GAB1 signalosome | 3.449742e-01 | 0.462 |
| R-HSA-180786 | Extension of Telomeres | 3.489258e-01 | 0.457 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.489258e-01 | 0.457 |
| R-HSA-191859 | snRNP Assembly | 3.489258e-01 | 0.457 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.489258e-01 | 0.457 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.489258e-01 | 0.457 |
| R-HSA-168249 | Innate Immune System | 3.524745e-01 | 0.453 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.542276e-01 | 0.451 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.545062e-01 | 0.450 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.555367e-01 | 0.449 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.569219e-01 | 0.447 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.569219e-01 | 0.447 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.569219e-01 | 0.447 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.569219e-01 | 0.447 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.569219e-01 | 0.447 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.569219e-01 | 0.447 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.621236e-01 | 0.441 |
| R-HSA-450294 | MAP kinase activation | 3.621236e-01 | 0.441 |
| R-HSA-166520 | Signaling by NTRKs | 3.643303e-01 | 0.439 |
| R-HSA-9824446 | Viral Infection Pathways | 3.651683e-01 | 0.438 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.685821e-01 | 0.433 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.686525e-01 | 0.433 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.686525e-01 | 0.433 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.686525e-01 | 0.433 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.686525e-01 | 0.433 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.686525e-01 | 0.433 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.686525e-01 | 0.433 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.686525e-01 | 0.433 |
| R-HSA-1181150 | Signaling by NODAL | 3.686525e-01 | 0.433 |
| R-HSA-445144 | Signal transduction by L1 | 3.686525e-01 | 0.433 |
| R-HSA-3322077 | Glycogen synthesis | 3.686525e-01 | 0.433 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.686853e-01 | 0.433 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.686853e-01 | 0.433 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.686853e-01 | 0.433 |
| R-HSA-186797 | Signaling by PDGF | 3.686853e-01 | 0.433 |
| R-HSA-9679506 | SARS-CoV Infections | 3.707485e-01 | 0.431 |
| R-HSA-211000 | Gene Silencing by RNA | 3.740965e-01 | 0.427 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.767382e-01 | 0.424 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.790466e-01 | 0.421 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.790466e-01 | 0.421 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.801697e-01 | 0.420 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.801697e-01 | 0.420 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.801697e-01 | 0.420 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.801697e-01 | 0.420 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.801697e-01 | 0.420 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.801697e-01 | 0.420 |
| R-HSA-210991 | Basigin interactions | 3.801697e-01 | 0.420 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.801697e-01 | 0.420 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.817279e-01 | 0.418 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.882064e-01 | 0.411 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.914776e-01 | 0.407 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.914776e-01 | 0.407 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.914776e-01 | 0.407 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.932469e-01 | 0.405 |
| R-HSA-72172 | mRNA Splicing | 3.942624e-01 | 0.404 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.010724e-01 | 0.397 |
| R-HSA-112040 | G-protein mediated events | 4.010724e-01 | 0.397 |
| R-HSA-6803529 | FGFR2 alternative splicing | 4.025799e-01 | 0.395 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 4.025799e-01 | 0.395 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.025799e-01 | 0.395 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 4.025799e-01 | 0.395 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.025799e-01 | 0.395 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.055871e-01 | 0.392 |
| R-HSA-167172 | Transcription of the HIV genome | 4.074578e-01 | 0.390 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.074578e-01 | 0.390 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.085514e-01 | 0.389 |
| R-HSA-877300 | Interferon gamma signaling | 4.096904e-01 | 0.388 |
| R-HSA-8854691 | Interleukin-20 family signaling | 4.134803e-01 | 0.384 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.134803e-01 | 0.384 |
| R-HSA-9018682 | Biosynthesis of maresins | 4.134803e-01 | 0.384 |
| R-HSA-3000170 | Syndecan interactions | 4.134803e-01 | 0.384 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.182966e-01 | 0.379 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.201286e-01 | 0.377 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.201286e-01 | 0.377 |
| R-HSA-448424 | Interleukin-17 signaling | 4.201286e-01 | 0.377 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.231496e-01 | 0.374 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.241824e-01 | 0.372 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.241824e-01 | 0.372 |
| R-HSA-429947 | Deadenylation of mRNA | 4.241824e-01 | 0.372 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 4.241824e-01 | 0.372 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.279889e-01 | 0.369 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.279889e-01 | 0.369 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.326602e-01 | 0.364 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.326602e-01 | 0.364 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.328140e-01 | 0.364 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.346899e-01 | 0.362 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.346899e-01 | 0.362 |
| R-HSA-3000157 | Laminin interactions | 4.346899e-01 | 0.362 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.346899e-01 | 0.362 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.346899e-01 | 0.362 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 4.346899e-01 | 0.362 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.346899e-01 | 0.362 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.346899e-01 | 0.362 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.346899e-01 | 0.362 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.388717e-01 | 0.358 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.424190e-01 | 0.354 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.424190e-01 | 0.354 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.450063e-01 | 0.352 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 4.450063e-01 | 0.352 |
| R-HSA-525793 | Myogenesis | 4.450063e-01 | 0.352 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.450063e-01 | 0.352 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.450063e-01 | 0.352 |
| R-HSA-70635 | Urea cycle | 4.450063e-01 | 0.352 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.450063e-01 | 0.352 |
| R-HSA-8852135 | Protein ubiquitination | 4.511826e-01 | 0.346 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.519607e-01 | 0.345 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.551351e-01 | 0.342 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.551351e-01 | 0.342 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.551351e-01 | 0.342 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.551351e-01 | 0.342 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.551351e-01 | 0.342 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.551351e-01 | 0.342 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.551351e-01 | 0.342 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.551351e-01 | 0.342 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.567065e-01 | 0.340 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.567065e-01 | 0.340 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.572805e-01 | 0.340 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.614351e-01 | 0.336 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.623826e-01 | 0.335 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.650797e-01 | 0.332 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.650797e-01 | 0.332 |
| R-HSA-622312 | Inflammasomes | 4.650797e-01 | 0.332 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.650797e-01 | 0.332 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.650797e-01 | 0.332 |
| R-HSA-9757110 | Prednisone ADME | 4.650797e-01 | 0.332 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.661460e-01 | 0.331 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.748433e-01 | 0.323 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.748433e-01 | 0.323 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.748433e-01 | 0.323 |
| R-HSA-5334118 | DNA methylation | 4.748433e-01 | 0.323 |
| R-HSA-194138 | Signaling by VEGF | 4.755130e-01 | 0.323 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.807362e-01 | 0.318 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.844293e-01 | 0.315 |
| R-HSA-2424491 | DAP12 signaling | 4.844293e-01 | 0.315 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.844293e-01 | 0.315 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.844293e-01 | 0.315 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.844293e-01 | 0.315 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.871707e-01 | 0.312 |
| R-HSA-611105 | Respiratory electron transport | 4.900871e-01 | 0.310 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.938409e-01 | 0.306 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.938409e-01 | 0.306 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.938409e-01 | 0.306 |
| R-HSA-168255 | Influenza Infection | 4.939981e-01 | 0.306 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.985914e-01 | 0.302 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 5.030813e-01 | 0.298 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.030813e-01 | 0.298 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.046068e-01 | 0.297 |
| R-HSA-5576891 | Cardiac conduction | 5.076793e-01 | 0.294 |
| R-HSA-1500620 | Meiosis | 5.103332e-01 | 0.292 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.121535e-01 | 0.291 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.121535e-01 | 0.291 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.121535e-01 | 0.291 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.121535e-01 | 0.291 |
| R-HSA-397795 | G-protein beta:gamma signalling | 5.121535e-01 | 0.291 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.121535e-01 | 0.291 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.121535e-01 | 0.291 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.121535e-01 | 0.291 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.121535e-01 | 0.291 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.160162e-01 | 0.287 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.210607e-01 | 0.283 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.210607e-01 | 0.283 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.210607e-01 | 0.283 |
| R-HSA-70268 | Pyruvate metabolism | 5.272507e-01 | 0.278 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.272507e-01 | 0.278 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.286033e-01 | 0.277 |
| R-HSA-5673000 | RAF activation | 5.298058e-01 | 0.276 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.298058e-01 | 0.276 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.298058e-01 | 0.276 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.298058e-01 | 0.276 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.298058e-01 | 0.276 |
| R-HSA-203615 | eNOS activation | 5.298058e-01 | 0.276 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.298058e-01 | 0.276 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.298058e-01 | 0.276 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.298058e-01 | 0.276 |
| R-HSA-392518 | Signal amplification | 5.298058e-01 | 0.276 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.298058e-01 | 0.276 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.298058e-01 | 0.276 |
| R-HSA-195721 | Signaling by WNT | 5.305629e-01 | 0.275 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.344171e-01 | 0.272 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.383917e-01 | 0.269 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.383917e-01 | 0.269 |
| R-HSA-169911 | Regulation of Apoptosis | 5.383917e-01 | 0.269 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.383917e-01 | 0.269 |
| R-HSA-381042 | PERK regulates gene expression | 5.383917e-01 | 0.269 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.398826e-01 | 0.268 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.468214e-01 | 0.262 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.468214e-01 | 0.262 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.468214e-01 | 0.262 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.468214e-01 | 0.262 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.468214e-01 | 0.262 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.468214e-01 | 0.262 |
| R-HSA-8853659 | RET signaling | 5.468214e-01 | 0.262 |
| R-HSA-6807070 | PTEN Regulation | 5.474759e-01 | 0.262 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.545576e-01 | 0.256 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.550976e-01 | 0.256 |
| R-HSA-4641257 | Degradation of AXIN | 5.550976e-01 | 0.256 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.550976e-01 | 0.256 |
| R-HSA-110331 | Cleavage of the damaged purine | 5.550976e-01 | 0.256 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.550976e-01 | 0.256 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.581158e-01 | 0.253 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.598838e-01 | 0.252 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.632232e-01 | 0.249 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.632232e-01 | 0.249 |
| R-HSA-73927 | Depurination | 5.632232e-01 | 0.249 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.632232e-01 | 0.249 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.632232e-01 | 0.249 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.651645e-01 | 0.248 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.651645e-01 | 0.248 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.712009e-01 | 0.243 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.712009e-01 | 0.243 |
| R-HSA-71336 | Pentose phosphate pathway | 5.712009e-01 | 0.243 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.712009e-01 | 0.243 |
| R-HSA-201556 | Signaling by ALK | 5.712009e-01 | 0.243 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.729407e-01 | 0.242 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.790333e-01 | 0.237 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.790333e-01 | 0.237 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.790333e-01 | 0.237 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.790333e-01 | 0.237 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.867232e-01 | 0.232 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.867232e-01 | 0.232 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 5.867232e-01 | 0.232 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.867232e-01 | 0.232 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.867232e-01 | 0.232 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.894166e-01 | 0.230 |
| R-HSA-9758941 | Gastrulation | 5.934716e-01 | 0.227 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.942731e-01 | 0.226 |
| R-HSA-167161 | HIV Transcription Initiation | 5.942731e-01 | 0.226 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.942731e-01 | 0.226 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.942731e-01 | 0.226 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.942731e-01 | 0.226 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.942731e-01 | 0.226 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 5.942731e-01 | 0.226 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.942731e-01 | 0.226 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.942731e-01 | 0.226 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.942731e-01 | 0.226 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.958890e-01 | 0.225 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.958890e-01 | 0.225 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.958890e-01 | 0.225 |
| R-HSA-991365 | Activation of GABAB receptors | 6.016854e-01 | 0.221 |
| R-HSA-977444 | GABA B receptor activation | 6.016854e-01 | 0.221 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.016854e-01 | 0.221 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 6.016854e-01 | 0.221 |
| R-HSA-165159 | MTOR signalling | 6.016854e-01 | 0.221 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 6.016854e-01 | 0.221 |
| R-HSA-73928 | Depyrimidination | 6.016854e-01 | 0.221 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 6.016854e-01 | 0.221 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.054804e-01 | 0.218 |
| R-HSA-70171 | Glycolysis | 6.057638e-01 | 0.218 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.057638e-01 | 0.218 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.089629e-01 | 0.215 |
| R-HSA-9710421 | Defective pyroptosis | 6.089629e-01 | 0.215 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.089629e-01 | 0.215 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.089629e-01 | 0.215 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.154552e-01 | 0.211 |
| R-HSA-9907900 | Proteasome assembly | 6.161078e-01 | 0.210 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.161078e-01 | 0.210 |
| R-HSA-2172127 | DAP12 interactions | 6.161078e-01 | 0.210 |
| R-HSA-5683826 | Surfactant metabolism | 6.161078e-01 | 0.210 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.231225e-01 | 0.205 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.231225e-01 | 0.205 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.231225e-01 | 0.205 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.231225e-01 | 0.205 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.231225e-01 | 0.205 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.231225e-01 | 0.205 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.231225e-01 | 0.205 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.231225e-01 | 0.205 |
| R-HSA-9824272 | Somitogenesis | 6.231225e-01 | 0.205 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.231225e-01 | 0.205 |
| R-HSA-111885 | Opioid Signalling | 6.249634e-01 | 0.204 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.300096e-01 | 0.201 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.300096e-01 | 0.201 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.300096e-01 | 0.201 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.300096e-01 | 0.201 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.300096e-01 | 0.201 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.300096e-01 | 0.201 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.300096e-01 | 0.201 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.300096e-01 | 0.201 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.342892e-01 | 0.198 |
| R-HSA-5663205 | Infectious disease | 6.367094e-01 | 0.196 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.388838e-01 | 0.195 |
| R-HSA-418346 | Platelet homeostasis | 6.388838e-01 | 0.195 |
| R-HSA-446728 | Cell junction organization | 6.411679e-01 | 0.193 |
| R-HSA-9031628 | NGF-stimulated transcription | 6.434096e-01 | 0.192 |
| R-HSA-425410 | Metal ion SLC transporters | 6.434096e-01 | 0.192 |
| R-HSA-69239 | Synthesis of DNA | 6.434331e-01 | 0.191 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.479372e-01 | 0.188 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.479372e-01 | 0.188 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.499271e-01 | 0.187 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.499271e-01 | 0.187 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.523962e-01 | 0.185 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.523962e-01 | 0.185 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 6.529977e-01 | 0.185 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.563259e-01 | 0.183 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.568102e-01 | 0.183 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.568102e-01 | 0.183 |
| R-HSA-912446 | Meiotic recombination | 6.626081e-01 | 0.179 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 6.626081e-01 | 0.179 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.626081e-01 | 0.179 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.655041e-01 | 0.177 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.655041e-01 | 0.177 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.687758e-01 | 0.175 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.687758e-01 | 0.175 |
| R-HSA-1643685 | Disease | 6.691169e-01 | 0.174 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.697842e-01 | 0.174 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.697842e-01 | 0.174 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.740201e-01 | 0.171 |
| R-HSA-1221632 | Meiotic synapsis | 6.748312e-01 | 0.171 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.748312e-01 | 0.171 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.759696e-01 | 0.170 |
| R-HSA-72306 | tRNA processing | 6.759696e-01 | 0.170 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.807763e-01 | 0.167 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.807763e-01 | 0.167 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.807763e-01 | 0.167 |
| R-HSA-156588 | Glucuronidation | 6.807763e-01 | 0.167 |
| R-HSA-72312 | rRNA processing | 6.815878e-01 | 0.166 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.823597e-01 | 0.166 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.862093e-01 | 0.164 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.862093e-01 | 0.164 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.862093e-01 | 0.164 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.862093e-01 | 0.164 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.862093e-01 | 0.164 |
| R-HSA-418597 | G alpha (z) signalling events | 6.866130e-01 | 0.163 |
| R-HSA-1483257 | Phospholipid metabolism | 6.884173e-01 | 0.162 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.923433e-01 | 0.160 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.923433e-01 | 0.160 |
| R-HSA-177929 | Signaling by EGFR | 6.923433e-01 | 0.160 |
| R-HSA-70326 | Glucose metabolism | 6.945420e-01 | 0.158 |
| R-HSA-5693538 | Homology Directed Repair | 6.985164e-01 | 0.156 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.034926e-01 | 0.153 |
| R-HSA-157118 | Signaling by NOTCH | 7.048213e-01 | 0.152 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.142392e-01 | 0.146 |
| R-HSA-977443 | GABA receptor activation | 7.142392e-01 | 0.146 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.142392e-01 | 0.146 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.142392e-01 | 0.146 |
| R-HSA-351202 | Metabolism of polyamines | 7.142392e-01 | 0.146 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 7.142392e-01 | 0.146 |
| R-HSA-379724 | tRNA Aminoacylation | 7.142392e-01 | 0.146 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.194660e-01 | 0.143 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.194660e-01 | 0.143 |
| R-HSA-112043 | PLC beta mediated events | 7.194660e-01 | 0.143 |
| R-HSA-6799198 | Complex I biogenesis | 7.296355e-01 | 0.137 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.296355e-01 | 0.137 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.323881e-01 | 0.135 |
| R-HSA-211981 | Xenobiotics | 7.345816e-01 | 0.134 |
| R-HSA-983712 | Ion channel transport | 7.367517e-01 | 0.133 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.394375e-01 | 0.131 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.442049e-01 | 0.128 |
| R-HSA-5688426 | Deubiquitination | 7.450324e-01 | 0.128 |
| R-HSA-392499 | Metabolism of proteins | 7.473990e-01 | 0.126 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.475590e-01 | 0.126 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.488853e-01 | 0.126 |
| R-HSA-1474165 | Reproduction | 7.497753e-01 | 0.125 |
| R-HSA-5218859 | Regulated Necrosis | 7.534804e-01 | 0.123 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.566707e-01 | 0.121 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.567542e-01 | 0.121 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.624207e-01 | 0.118 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.624207e-01 | 0.118 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.624207e-01 | 0.118 |
| R-HSA-3000178 | ECM proteoglycans | 7.667689e-01 | 0.115 |
| R-HSA-8978934 | Metabolism of cofactors | 7.667689e-01 | 0.115 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.667689e-01 | 0.115 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.667689e-01 | 0.115 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.710378e-01 | 0.113 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.710378e-01 | 0.113 |
| R-HSA-9749641 | Aspirin ADME | 7.752288e-01 | 0.111 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.755175e-01 | 0.110 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.755769e-01 | 0.110 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.786337e-01 | 0.109 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.793434e-01 | 0.108 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.833829e-01 | 0.106 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.833829e-01 | 0.106 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.833829e-01 | 0.106 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.873487e-01 | 0.104 |
| R-HSA-5689603 | UCH proteinases | 7.873487e-01 | 0.104 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.873487e-01 | 0.104 |
| R-HSA-216083 | Integrin cell surface interactions | 7.950645e-01 | 0.100 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.950645e-01 | 0.100 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.950645e-01 | 0.100 |
| R-HSA-5619084 | ABC transporter disorders | 7.950645e-01 | 0.100 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.988171e-01 | 0.098 |
| R-HSA-5654738 | Signaling by FGFR2 | 8.025012e-01 | 0.096 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.025012e-01 | 0.096 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 8.061181e-01 | 0.094 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.096690e-01 | 0.092 |
| R-HSA-418990 | Adherens junctions interactions | 8.139721e-01 | 0.089 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.151710e-01 | 0.089 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.165775e-01 | 0.088 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.202893e-01 | 0.086 |
| R-HSA-8951664 | Neddylation | 8.205286e-01 | 0.086 |
| R-HSA-69306 | DNA Replication | 8.228006e-01 | 0.085 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 8.232360e-01 | 0.084 |
| R-HSA-73887 | Death Receptor Signaling | 8.252805e-01 | 0.083 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.264744e-01 | 0.083 |
| R-HSA-9610379 | HCMV Late Events | 8.325345e-01 | 0.080 |
| R-HSA-156902 | Peptide chain elongation | 8.327748e-01 | 0.079 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.327748e-01 | 0.079 |
| R-HSA-73884 | Base Excision Repair | 8.388472e-01 | 0.076 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.388472e-01 | 0.076 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.395163e-01 | 0.076 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.418005e-01 | 0.075 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.475462e-01 | 0.072 |
| R-HSA-2029481 | FCGR activation | 8.503405e-01 | 0.070 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.522662e-01 | 0.069 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.530839e-01 | 0.069 |
| R-HSA-5619102 | SLC transporter disorders | 8.547951e-01 | 0.068 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.557771e-01 | 0.068 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.584211e-01 | 0.066 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.584211e-01 | 0.066 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.635650e-01 | 0.064 |
| R-HSA-418555 | G alpha (s) signalling events | 8.648854e-01 | 0.063 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.660667e-01 | 0.062 |
| R-HSA-190236 | Signaling by FGFR | 8.660667e-01 | 0.062 |
| R-HSA-3214847 | HATs acetylate histones | 8.685227e-01 | 0.061 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.695278e-01 | 0.061 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.724916e-01 | 0.059 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.733008e-01 | 0.059 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.756246e-01 | 0.058 |
| R-HSA-421270 | Cell-cell junction organization | 8.759203e-01 | 0.058 |
| R-HSA-192823 | Viral mRNA Translation | 8.779059e-01 | 0.057 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.801454e-01 | 0.055 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 8.823441e-01 | 0.054 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.845025e-01 | 0.053 |
| R-HSA-1474244 | Extracellular matrix organization | 8.874712e-01 | 0.052 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.887017e-01 | 0.051 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.907438e-01 | 0.050 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.934661e-01 | 0.049 |
| R-HSA-6803157 | Antimicrobial peptides | 8.966490e-01 | 0.047 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.040306e-01 | 0.044 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.075220e-01 | 0.042 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.117591e-01 | 0.040 |
| R-HSA-72766 | Translation | 9.178922e-01 | 0.037 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.202662e-01 | 0.036 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.217309e-01 | 0.035 |
| R-HSA-977606 | Regulation of Complement cascade | 9.231687e-01 | 0.035 |
| R-HSA-9909396 | Circadian clock | 9.349804e-01 | 0.029 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.387012e-01 | 0.027 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.489190e-01 | 0.023 |
| R-HSA-166658 | Complement cascade | 9.507812e-01 | 0.022 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.567819e-01 | 0.019 |
| R-HSA-9711097 | Cellular response to starvation | 9.613413e-01 | 0.017 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.654211e-01 | 0.015 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.672972e-01 | 0.014 |
| R-HSA-416476 | G alpha (q) signalling events | 9.674243e-01 | 0.014 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.707503e-01 | 0.013 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.738751e-01 | 0.011 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.816296e-01 | 0.008 |
| R-HSA-428157 | Sphingolipid metabolism | 9.829541e-01 | 0.007 |
| R-HSA-6805567 | Keratinization | 9.847578e-01 | 0.007 |
| R-HSA-9748784 | Drug ADME | 9.878143e-01 | 0.005 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.900759e-01 | 0.004 |
| R-HSA-15869 | Metabolism of nucleotides | 9.912920e-01 | 0.004 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.917666e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.955119e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.963032e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.968724e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.975270e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.989999e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.990657e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.992105e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.994527e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999891e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999997e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.823 | 0.148 | 2 | 0.864 |
GCN2 |
0.814 | 0.110 | 2 | 0.807 |
PRKD1 |
0.812 | 0.028 | -3 | 0.082 |
PRKD2 |
0.811 | 0.009 | -3 | 0.074 |
CLK3 |
0.810 | 0.088 | 1 | 0.829 |
DSTYK |
0.809 | 0.025 | 2 | 0.887 |
CDC7 |
0.808 | 0.012 | 1 | 0.839 |
PRPK |
0.807 | 0.001 | -1 | 0.894 |
PIM3 |
0.806 | -0.026 | -3 | 0.121 |
MOS |
0.806 | 0.062 | 1 | 0.872 |
TGFBR2 |
0.806 | 0.105 | -2 | 0.891 |
BMPR2 |
0.805 | 0.110 | -2 | 0.928 |
CAMK1B |
0.805 | -0.026 | -3 | 0.117 |
CAMK2G |
0.805 | 0.030 | 2 | 0.874 |
MAPKAPK2 |
0.804 | -0.011 | -3 | 0.080 |
PLK2 |
0.804 | 0.501 | -3 | 0.550 |
CDKL1 |
0.804 | -0.032 | -3 | 0.105 |
PIM1 |
0.804 | -0.004 | -3 | 0.097 |
SRPK2 |
0.803 | -0.013 | -3 | 0.075 |
NEK6 |
0.802 | -0.016 | -2 | 0.921 |
TBK1 |
0.802 | 0.016 | 1 | 0.765 |
IKKB |
0.802 | -0.039 | -2 | 0.792 |
RSK2 |
0.802 | -0.030 | -3 | 0.090 |
PLK3 |
0.801 | 0.294 | 2 | 0.804 |
SRPK1 |
0.801 | -0.017 | -3 | 0.082 |
NDR2 |
0.801 | -0.046 | -3 | 0.107 |
ATR |
0.801 | 0.004 | 1 | 0.875 |
MAPKAPK3 |
0.801 | -0.049 | -3 | 0.065 |
ULK2 |
0.800 | -0.102 | 2 | 0.780 |
PDHK4 |
0.800 | -0.149 | 1 | 0.869 |
PRKD3 |
0.800 | -0.004 | -3 | 0.070 |
MTOR |
0.800 | -0.051 | 1 | 0.794 |
NUAK2 |
0.800 | -0.028 | -3 | 0.102 |
NEK7 |
0.799 | -0.072 | -3 | 0.104 |
PKN3 |
0.799 | -0.042 | -3 | 0.100 |
ATM |
0.799 | 0.092 | 1 | 0.818 |
BMPR1B |
0.799 | 0.184 | 1 | 0.781 |
RAF1 |
0.799 | -0.072 | 1 | 0.864 |
CAMK2D |
0.799 | -0.023 | -3 | 0.077 |
CAMK2B |
0.799 | 0.052 | 2 | 0.834 |
IKKE |
0.798 | -0.012 | 1 | 0.762 |
P90RSK |
0.798 | -0.046 | -3 | 0.091 |
TGFBR1 |
0.797 | 0.173 | -2 | 0.895 |
IKKA |
0.797 | 0.055 | -2 | 0.792 |
RSK3 |
0.797 | -0.041 | -3 | 0.111 |
CDKL5 |
0.797 | -0.035 | -3 | 0.092 |
CHK1 |
0.796 | 0.069 | -3 | 0.152 |
CAMK2A |
0.796 | 0.033 | 2 | 0.871 |
PDHK1 |
0.796 | -0.130 | 1 | 0.868 |
MLK1 |
0.795 | 0.019 | 2 | 0.812 |
NIK |
0.794 | -0.067 | -3 | 0.121 |
NLK |
0.794 | -0.053 | 1 | 0.823 |
ULK1 |
0.794 | -0.105 | -3 | 0.108 |
ACVR2A |
0.793 | 0.174 | -2 | 0.899 |
LATS2 |
0.793 | -0.047 | -5 | 0.667 |
GRK6 |
0.793 | 0.041 | 1 | 0.834 |
PKCD |
0.793 | -0.012 | 2 | 0.807 |
GRK4 |
0.793 | 0.034 | -2 | 0.853 |
FAM20C |
0.793 | 0.057 | 2 | 0.604 |
KIS |
0.792 | 0.042 | 1 | 0.674 |
GRK5 |
0.792 | -0.060 | -3 | 0.147 |
ACVR2B |
0.792 | 0.164 | -2 | 0.904 |
NUAK1 |
0.792 | -0.036 | -3 | 0.090 |
ALK4 |
0.792 | 0.137 | -2 | 0.910 |
TSSK2 |
0.792 | 0.022 | -5 | 0.868 |
MARK4 |
0.792 | -0.042 | 4 | 0.880 |
SRPK3 |
0.792 | -0.022 | -3 | 0.091 |
ERK5 |
0.792 | -0.026 | 1 | 0.794 |
NDR1 |
0.791 | -0.079 | -3 | 0.098 |
WNK1 |
0.791 | -0.086 | -2 | 0.834 |
TSSK1 |
0.791 | 0.006 | -3 | 0.106 |
CAMLCK |
0.791 | -0.060 | -2 | 0.845 |
BMPR1A |
0.790 | 0.221 | 1 | 0.764 |
PKN2 |
0.790 | -0.070 | -3 | 0.079 |
AMPKA1 |
0.790 | -0.057 | -3 | 0.095 |
MST4 |
0.790 | -0.033 | 2 | 0.833 |
SKMLCK |
0.789 | -0.066 | -2 | 0.829 |
NEK9 |
0.789 | -0.103 | 2 | 0.826 |
ALK2 |
0.789 | 0.163 | -2 | 0.890 |
DAPK2 |
0.788 | -0.089 | -3 | 0.105 |
PLK1 |
0.788 | 0.053 | -2 | 0.902 |
ICK |
0.788 | -0.052 | -3 | 0.100 |
CHAK2 |
0.787 | -0.038 | -1 | 0.860 |
AMPKA2 |
0.787 | -0.057 | -3 | 0.085 |
CLK1 |
0.787 | -0.017 | -3 | 0.076 |
MSK2 |
0.787 | -0.069 | -3 | 0.078 |
BCKDK |
0.787 | -0.105 | -1 | 0.826 |
SIK |
0.787 | -0.043 | -3 | 0.076 |
P70S6KB |
0.786 | -0.079 | -3 | 0.087 |
HIPK4 |
0.786 | -0.048 | 1 | 0.806 |
GRK1 |
0.786 | -0.005 | -2 | 0.751 |
CLK4 |
0.785 | -0.024 | -3 | 0.083 |
TLK2 |
0.785 | 0.080 | 1 | 0.859 |
MLK3 |
0.785 | 0.033 | 2 | 0.763 |
CAMK4 |
0.785 | -0.090 | -3 | 0.088 |
CDK8 |
0.785 | -0.009 | 1 | 0.654 |
RIPK3 |
0.785 | -0.110 | 3 | 0.795 |
ANKRD3 |
0.785 | -0.057 | 1 | 0.885 |
HUNK |
0.785 | -0.109 | 2 | 0.789 |
MLK4 |
0.783 | 0.086 | 2 | 0.724 |
PKR |
0.783 | 0.045 | 1 | 0.886 |
RSK4 |
0.783 | -0.041 | -3 | 0.091 |
CK1E |
0.783 | -0.064 | -3 | 0.101 |
MELK |
0.783 | -0.082 | -3 | 0.068 |
PKACG |
0.783 | -0.076 | -2 | 0.725 |
MAPKAPK5 |
0.782 | -0.095 | -3 | 0.055 |
DLK |
0.782 | -0.096 | 1 | 0.854 |
MSK1 |
0.782 | -0.045 | -3 | 0.077 |
TTBK2 |
0.782 | -0.066 | 2 | 0.726 |
WNK3 |
0.782 | -0.177 | 1 | 0.855 |
PRKX |
0.782 | -0.020 | -3 | 0.059 |
SMG1 |
0.782 | 0.003 | 1 | 0.839 |
LATS1 |
0.781 | -0.032 | -3 | 0.109 |
DNAPK |
0.781 | 0.034 | 1 | 0.764 |
CAMK1D |
0.781 | -0.032 | -3 | 0.063 |
MASTL |
0.780 | -0.191 | -2 | 0.820 |
IRE2 |
0.780 | -0.007 | 2 | 0.753 |
CAMK1G |
0.780 | -0.051 | -3 | 0.071 |
MLK2 |
0.780 | -0.083 | 2 | 0.803 |
IRE1 |
0.780 | -0.061 | 1 | 0.848 |
PKCB |
0.780 | -0.036 | 2 | 0.756 |
TLK1 |
0.780 | 0.068 | -2 | 0.915 |
GRK2 |
0.780 | 0.055 | -2 | 0.777 |
QSK |
0.780 | -0.046 | 4 | 0.855 |
PKACB |
0.779 | -0.041 | -2 | 0.659 |
MNK2 |
0.779 | -0.052 | -2 | 0.773 |
PHKG1 |
0.779 | -0.073 | -3 | 0.085 |
NIM1 |
0.779 | -0.088 | 3 | 0.834 |
CK1G1 |
0.779 | -0.070 | -3 | 0.093 |
AKT2 |
0.779 | -0.055 | -3 | 0.063 |
GRK7 |
0.778 | 0.053 | 1 | 0.750 |
BRSK1 |
0.778 | -0.071 | -3 | 0.085 |
HRI |
0.778 | -0.012 | -2 | 0.924 |
QIK |
0.778 | -0.097 | -3 | 0.075 |
YSK4 |
0.778 | -0.029 | 1 | 0.804 |
MYLK4 |
0.777 | -0.064 | -2 | 0.753 |
PERK |
0.777 | 0.042 | -2 | 0.889 |
PKCA |
0.777 | -0.041 | 2 | 0.748 |
CK1D |
0.777 | -0.077 | -3 | 0.066 |
CDK19 |
0.777 | -0.016 | 1 | 0.612 |
MEK1 |
0.777 | -0.070 | 2 | 0.817 |
AURC |
0.777 | -0.041 | -2 | 0.630 |
DCAMKL1 |
0.777 | -0.061 | -3 | 0.089 |
PIM2 |
0.776 | -0.057 | -3 | 0.074 |
CLK2 |
0.776 | 0.003 | -3 | 0.099 |
PKCG |
0.776 | -0.061 | 2 | 0.767 |
PAK1 |
0.776 | -0.076 | -2 | 0.755 |
CK1A2 |
0.775 | -0.074 | -3 | 0.071 |
CAMK1A |
0.775 | -0.020 | -3 | 0.058 |
NEK2 |
0.775 | -0.126 | 2 | 0.806 |
RIPK1 |
0.775 | -0.182 | 1 | 0.850 |
PKCH |
0.774 | -0.058 | 2 | 0.742 |
MARK3 |
0.774 | -0.033 | 4 | 0.818 |
MARK2 |
0.774 | -0.033 | 4 | 0.783 |
PAK3 |
0.773 | -0.108 | -2 | 0.760 |
PINK1 |
0.773 | -0.076 | 1 | 0.856 |
SGK3 |
0.773 | -0.075 | -3 | 0.060 |
PAK6 |
0.772 | -0.058 | -2 | 0.680 |
SBK |
0.772 | -0.035 | -3 | 0.045 |
VRK2 |
0.772 | -0.154 | 1 | 0.895 |
DCAMKL2 |
0.772 | -0.051 | -3 | 0.094 |
DYRK2 |
0.772 | -0.046 | 1 | 0.688 |
CHK2 |
0.771 | -0.046 | -3 | 0.048 |
PKACA |
0.771 | -0.048 | -2 | 0.608 |
BRSK2 |
0.771 | -0.105 | -3 | 0.069 |
MNK1 |
0.771 | -0.073 | -2 | 0.785 |
CDK1 |
0.771 | 0.017 | 1 | 0.596 |
GRK3 |
0.771 | 0.051 | -2 | 0.728 |
PKG2 |
0.771 | -0.066 | -2 | 0.657 |
CHAK1 |
0.770 | -0.083 | 2 | 0.767 |
MARK1 |
0.770 | -0.056 | 4 | 0.841 |
PRP4 |
0.770 | -0.058 | -3 | 0.097 |
AURB |
0.770 | -0.049 | -2 | 0.633 |
PKCZ |
0.769 | -0.083 | 2 | 0.783 |
BRAF |
0.769 | -0.017 | -4 | 0.827 |
CDK5 |
0.769 | 0.002 | 1 | 0.672 |
CDK2 |
0.768 | 0.001 | 1 | 0.682 |
P38A |
0.768 | 0.006 | 1 | 0.682 |
SMMLCK |
0.768 | -0.070 | -3 | 0.087 |
AURA |
0.768 | -0.026 | -2 | 0.608 |
MEKK1 |
0.768 | -0.032 | 1 | 0.854 |
PHKG2 |
0.768 | -0.082 | -3 | 0.074 |
CDK7 |
0.768 | -0.053 | 1 | 0.653 |
MEKK2 |
0.767 | 0.022 | 2 | 0.793 |
JNK2 |
0.767 | 0.012 | 1 | 0.585 |
JNK3 |
0.766 | -0.003 | 1 | 0.622 |
MEKK3 |
0.766 | -0.042 | 1 | 0.830 |
NEK5 |
0.766 | -0.093 | 1 | 0.872 |
AKT1 |
0.765 | -0.064 | -3 | 0.052 |
CDK13 |
0.765 | -0.044 | 1 | 0.619 |
P70S6K |
0.764 | -0.096 | -3 | 0.057 |
PAK2 |
0.764 | -0.109 | -2 | 0.742 |
ZAK |
0.764 | -0.041 | 1 | 0.822 |
CDK18 |
0.764 | -0.019 | 1 | 0.573 |
PLK4 |
0.764 | -0.075 | 2 | 0.622 |
SNRK |
0.764 | -0.171 | 2 | 0.689 |
DRAK1 |
0.764 | -0.083 | 1 | 0.758 |
DYRK1A |
0.763 | -0.062 | 1 | 0.725 |
ERK1 |
0.763 | -0.002 | 1 | 0.592 |
P38B |
0.763 | -0.002 | 1 | 0.599 |
CK2A2 |
0.762 | 0.077 | 1 | 0.698 |
PKCT |
0.762 | -0.074 | 2 | 0.745 |
HIPK1 |
0.761 | -0.046 | 1 | 0.708 |
P38G |
0.761 | 0.006 | 1 | 0.506 |
MEK5 |
0.761 | -0.154 | 2 | 0.809 |
MST2 |
0.761 | 0.053 | 1 | 0.835 |
ERK2 |
0.761 | -0.020 | 1 | 0.640 |
SGK1 |
0.761 | -0.056 | -3 | 0.051 |
TTBK1 |
0.761 | -0.081 | 2 | 0.661 |
WNK4 |
0.760 | -0.123 | -2 | 0.822 |
SSTK |
0.760 | -0.060 | 4 | 0.850 |
TAO3 |
0.760 | -0.042 | 1 | 0.821 |
HIPK2 |
0.760 | -0.029 | 1 | 0.593 |
PKN1 |
0.760 | -0.068 | -3 | 0.048 |
PASK |
0.760 | -0.048 | -3 | 0.120 |
AKT3 |
0.759 | -0.056 | -3 | 0.048 |
CDK17 |
0.759 | -0.019 | 1 | 0.513 |
HIPK3 |
0.757 | -0.065 | 1 | 0.701 |
DAPK3 |
0.757 | -0.063 | -3 | 0.087 |
IRAK4 |
0.757 | -0.122 | 1 | 0.854 |
EEF2K |
0.757 | 0.029 | 3 | 0.883 |
NEK8 |
0.757 | -0.094 | 2 | 0.822 |
PKCE |
0.756 | -0.047 | 2 | 0.749 |
GAK |
0.756 | -0.016 | 1 | 0.858 |
MST3 |
0.756 | -0.080 | 2 | 0.830 |
BUB1 |
0.756 | 0.043 | -5 | 0.848 |
CDK12 |
0.756 | -0.049 | 1 | 0.590 |
DYRK3 |
0.756 | -0.058 | 1 | 0.718 |
MPSK1 |
0.756 | -0.056 | 1 | 0.832 |
DYRK4 |
0.756 | -0.030 | 1 | 0.601 |
CDK3 |
0.756 | 0.015 | 1 | 0.532 |
PKCI |
0.754 | -0.082 | 2 | 0.752 |
TAO2 |
0.754 | -0.073 | 2 | 0.855 |
MRCKA |
0.753 | -0.061 | -3 | 0.065 |
CAMKK1 |
0.753 | -0.162 | -2 | 0.756 |
GSK3A |
0.753 | 0.014 | 4 | 0.488 |
MRCKB |
0.753 | -0.061 | -3 | 0.059 |
P38D |
0.753 | 0.003 | 1 | 0.544 |
CDK9 |
0.753 | -0.078 | 1 | 0.627 |
MST1 |
0.752 | -0.007 | 1 | 0.826 |
GSK3B |
0.752 | -0.019 | 4 | 0.478 |
CDK16 |
0.751 | -0.007 | 1 | 0.531 |
DYRK1B |
0.750 | -0.057 | 1 | 0.629 |
TNIK |
0.750 | -0.023 | 3 | 0.914 |
NEK4 |
0.750 | -0.139 | 1 | 0.839 |
DAPK1 |
0.750 | -0.070 | -3 | 0.082 |
GCK |
0.750 | -0.055 | 1 | 0.827 |
IRAK1 |
0.750 | -0.171 | -1 | 0.797 |
NEK11 |
0.750 | -0.158 | 1 | 0.816 |
CDK14 |
0.749 | -0.049 | 1 | 0.620 |
TAK1 |
0.749 | -0.079 | 1 | 0.865 |
HGK |
0.749 | -0.056 | 3 | 0.905 |
ERK7 |
0.749 | 0.000 | 2 | 0.562 |
PAK5 |
0.749 | -0.086 | -2 | 0.611 |
CK2A1 |
0.748 | 0.045 | 1 | 0.675 |
CAMKK2 |
0.748 | -0.181 | -2 | 0.749 |
MINK |
0.748 | -0.049 | 1 | 0.834 |
TTK |
0.747 | 0.136 | -2 | 0.902 |
LKB1 |
0.747 | -0.170 | -3 | 0.072 |
NEK1 |
0.746 | -0.133 | 1 | 0.843 |
ROCK2 |
0.746 | -0.065 | -3 | 0.070 |
MAK |
0.746 | -0.034 | -2 | 0.701 |
DMPK1 |
0.746 | -0.040 | -3 | 0.074 |
PDK1 |
0.746 | -0.126 | 1 | 0.811 |
PAK4 |
0.745 | -0.079 | -2 | 0.620 |
MAP3K15 |
0.745 | -0.098 | 1 | 0.801 |
MEKK6 |
0.745 | -0.123 | 1 | 0.835 |
LRRK2 |
0.745 | -0.128 | 2 | 0.849 |
JNK1 |
0.744 | -0.000 | 1 | 0.565 |
CDK10 |
0.744 | -0.050 | 1 | 0.605 |
CK1A |
0.744 | -0.089 | -3 | 0.060 |
LOK |
0.743 | -0.084 | -2 | 0.771 |
VRK1 |
0.742 | -0.113 | 2 | 0.819 |
SLK |
0.741 | -0.076 | -2 | 0.719 |
MEK2 |
0.740 | -0.125 | 2 | 0.781 |
CRIK |
0.740 | -0.063 | -3 | 0.056 |
HPK1 |
0.740 | -0.101 | 1 | 0.807 |
MOK |
0.739 | -0.057 | 1 | 0.727 |
PKG1 |
0.739 | -0.079 | -2 | 0.570 |
KHS1 |
0.738 | -0.070 | 1 | 0.815 |
BIKE |
0.738 | 0.019 | 1 | 0.736 |
CDK6 |
0.737 | -0.036 | 1 | 0.601 |
RIPK2 |
0.736 | -0.181 | 1 | 0.777 |
YSK1 |
0.736 | -0.089 | 2 | 0.804 |
KHS2 |
0.736 | -0.053 | 1 | 0.824 |
ROCK1 |
0.735 | -0.071 | -3 | 0.064 |
STK33 |
0.735 | -0.133 | 2 | 0.644 |
PDHK3_TYR |
0.735 | -0.011 | 4 | 0.943 |
PBK |
0.735 | -0.070 | 1 | 0.792 |
OSR1 |
0.735 | -0.009 | 2 | 0.766 |
NEK3 |
0.734 | -0.144 | 1 | 0.806 |
CDK4 |
0.732 | -0.050 | 1 | 0.579 |
CK1G3 |
0.730 | -0.088 | -3 | 0.048 |
BMPR2_TYR |
0.728 | 0.049 | -1 | 0.889 |
ALPHAK3 |
0.728 | 0.017 | -1 | 0.805 |
MAP2K6_TYR |
0.727 | -0.007 | -1 | 0.902 |
TXK |
0.727 | 0.203 | 1 | 0.829 |
MAP2K4_TYR |
0.727 | -0.062 | -1 | 0.909 |
MYO3B |
0.727 | -0.067 | 2 | 0.818 |
EPHA6 |
0.726 | 0.087 | -1 | 0.872 |
TESK1_TYR |
0.725 | -0.110 | 3 | 0.930 |
YANK3 |
0.725 | -0.054 | 2 | 0.444 |
MAP2K7_TYR |
0.725 | -0.124 | 2 | 0.865 |
PDHK4_TYR |
0.725 | -0.050 | 2 | 0.882 |
PKMYT1_TYR |
0.724 | -0.081 | 3 | 0.899 |
HASPIN |
0.724 | -0.046 | -1 | 0.715 |
EPHB4 |
0.724 | 0.101 | -1 | 0.859 |
MYO3A |
0.724 | -0.056 | 1 | 0.830 |
PDHK1_TYR |
0.724 | -0.018 | -1 | 0.906 |
AAK1 |
0.723 | 0.037 | 1 | 0.631 |
ASK1 |
0.723 | -0.110 | 1 | 0.785 |
RET |
0.723 | 0.050 | 1 | 0.830 |
YES1 |
0.722 | 0.159 | -1 | 0.872 |
TAO1 |
0.722 | -0.091 | 1 | 0.764 |
ABL2 |
0.721 | 0.114 | -1 | 0.848 |
SRMS |
0.721 | 0.142 | 1 | 0.841 |
PINK1_TYR |
0.720 | -0.112 | 1 | 0.850 |
FER |
0.719 | 0.088 | 1 | 0.862 |
TYRO3 |
0.719 | 0.021 | 3 | 0.849 |
CSF1R |
0.718 | 0.097 | 3 | 0.838 |
EPHB2 |
0.718 | 0.128 | -1 | 0.841 |
EPHA4 |
0.718 | 0.059 | 2 | 0.800 |
ABL1 |
0.718 | 0.098 | -1 | 0.847 |
FGR |
0.718 | 0.041 | 1 | 0.859 |
TYK2 |
0.717 | -0.058 | 1 | 0.830 |
LCK |
0.717 | 0.141 | -1 | 0.856 |
LIMK2_TYR |
0.717 | -0.131 | -3 | 0.104 |
HCK |
0.716 | 0.088 | -1 | 0.858 |
LIMK1_TYR |
0.716 | -0.147 | 2 | 0.851 |
BLK |
0.716 | 0.147 | -1 | 0.851 |
MST1R |
0.716 | -0.038 | 3 | 0.854 |
JAK2 |
0.716 | -0.039 | 1 | 0.825 |
ITK |
0.715 | 0.082 | -1 | 0.841 |
EPHB1 |
0.715 | 0.060 | 1 | 0.844 |
ROS1 |
0.715 | -0.033 | 3 | 0.822 |
FYN |
0.715 | 0.187 | -1 | 0.827 |
STLK3 |
0.713 | -0.108 | 1 | 0.788 |
INSRR |
0.713 | 0.047 | 3 | 0.795 |
FLT3 |
0.713 | 0.063 | 3 | 0.842 |
TEC |
0.712 | 0.086 | -1 | 0.790 |
BTK |
0.712 | 0.076 | -1 | 0.818 |
KIT |
0.712 | 0.050 | 3 | 0.839 |
EPHB3 |
0.711 | 0.022 | -1 | 0.840 |
JAK3 |
0.711 | -0.021 | 1 | 0.808 |
PDGFRB |
0.711 | 0.005 | 3 | 0.854 |
BMX |
0.711 | 0.062 | -1 | 0.769 |
DDR1 |
0.710 | -0.121 | 4 | 0.870 |
LYN |
0.710 | 0.151 | 3 | 0.763 |
FGFR2 |
0.709 | 0.029 | 3 | 0.842 |
MERTK |
0.709 | 0.057 | 3 | 0.823 |
TNNI3K_TYR |
0.708 | -0.030 | 1 | 0.868 |
TNK2 |
0.707 | -0.066 | 3 | 0.794 |
KDR |
0.707 | -0.013 | 3 | 0.812 |
JAK1 |
0.707 | -0.022 | 1 | 0.776 |
PTK6 |
0.707 | 0.053 | -1 | 0.782 |
EPHA7 |
0.706 | 0.047 | 2 | 0.799 |
FRK |
0.705 | 0.097 | -1 | 0.862 |
FLT1 |
0.704 | 0.021 | -1 | 0.845 |
CSK |
0.704 | 0.146 | 2 | 0.802 |
NTRK1 |
0.704 | 0.011 | -1 | 0.848 |
EPHA3 |
0.704 | -0.000 | 2 | 0.779 |
AXL |
0.704 | -0.023 | 3 | 0.820 |
MET |
0.704 | 0.033 | 3 | 0.828 |
FGFR1 |
0.704 | -0.024 | 3 | 0.813 |
LTK |
0.704 | 0.024 | 3 | 0.794 |
MATK |
0.703 | 0.050 | -1 | 0.773 |
EPHA5 |
0.703 | 0.082 | 2 | 0.785 |
PDGFRA |
0.703 | -0.045 | 3 | 0.855 |
TEK |
0.703 | -0.048 | 3 | 0.783 |
SRC |
0.703 | 0.134 | -1 | 0.829 |
ERBB2 |
0.702 | 0.023 | 1 | 0.771 |
PTK2B |
0.701 | 0.054 | -1 | 0.825 |
EPHA8 |
0.701 | 0.096 | -1 | 0.811 |
NEK10_TYR |
0.701 | -0.091 | 1 | 0.700 |
WEE1_TYR |
0.701 | -0.053 | -1 | 0.800 |
EGFR |
0.701 | 0.078 | 1 | 0.671 |
ALK |
0.701 | -0.001 | 3 | 0.769 |
EPHA1 |
0.701 | 0.002 | 3 | 0.803 |
CK1G2 |
0.700 | -0.082 | -3 | 0.073 |
NTRK2 |
0.700 | -0.008 | 3 | 0.802 |
FGFR3 |
0.699 | 0.022 | 3 | 0.814 |
TNK1 |
0.699 | -0.116 | 3 | 0.827 |
FLT4 |
0.698 | -0.024 | 3 | 0.804 |
PTK2 |
0.697 | 0.085 | -1 | 0.793 |
NTRK3 |
0.696 | -0.001 | -1 | 0.799 |
INSR |
0.696 | -0.007 | 3 | 0.766 |
FGFR4 |
0.696 | 0.081 | -1 | 0.803 |
SYK |
0.694 | 0.076 | -1 | 0.781 |
YANK2 |
0.694 | -0.061 | 2 | 0.460 |
DDR2 |
0.693 | -0.068 | 3 | 0.783 |
EPHA2 |
0.691 | 0.061 | -1 | 0.790 |
ERBB4 |
0.685 | 0.044 | 1 | 0.678 |
IGF1R |
0.684 | 0.009 | 3 | 0.708 |
MUSK |
0.679 | -0.069 | 1 | 0.660 |
FES |
0.676 | 0.006 | -1 | 0.752 |
ZAP70 |
0.663 | -0.020 | -1 | 0.718 |