Motif 566 (n=197)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B5ME19 | EIF3CL | S166 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| B5ME19 | EIF3CL | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| B5ME19 | EIF3CL | S530 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| D6RIA3 | C4orf54 | S1165 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| O00273 | DFFA | S232 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00515 | LAD1 | S385 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14647 | CHD2 | S156 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O15061 | SYNM | S584 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15091 | PRORP | S94 | ochoa | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}. |
| O43561 | LAT | S213 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43683 | BUB1 | S318 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60231 | DHX16 | S103 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| O60271 | SPAG9 | S339 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75475 | PSIP1 | S347 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75643 | SNRNP200 | S756 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O94953 | KDM4B | S632 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95071 | UBR5 | S327 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95071 | UBR5 | S1990 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95299 | NDUFA10 | S250 | psp | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95425 | SVIL | S938 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P05107 | ITGB2 | S346 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
| P08133 | ANXA6 | S422 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P08240 | SRPRA | S142 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P12882 | MYH1 | S1714 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1710 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1712 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1713 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13631 | RARG | S176 | ochoa | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
| P19338 | NCL | S34 | ochoa|psp | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P21728 | DRD1 | S254 | psp | D(1A) dopamine receptor (Dopamine D1 receptor) | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| P21730 | C5AR1 | S327 | ochoa|psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P29597 | TYK2 | S613 | ochoa | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| P31431 | SDC4 | S179 | psp | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}. |
| P34741 | SDC2 | S178 | ochoa | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | Cell surface proteoglycan which regulates dendritic arbor morphogenesis. {ECO:0000250|UniProtKB:P43407}. |
| P34910 | EVI2B | S295 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35269 | GTF2F1 | S217 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35659 | DEK | S231 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35680 | HNF1B | S80 | ochoa | Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1) | Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:17924661, PubMed:7900999). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). {ECO:0000250|UniProtKB:Q03365, ECO:0000269|PubMed:17924661, ECO:0000269|PubMed:24204001, ECO:0000269|PubMed:7900999}. |
| P35716 | SOX11 | S71 | ochoa | Transcription factor SOX-11 | Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}. |
| P37173 | TGFBR2 | S213 | psp | TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.; FUNCTION: [Isoform 1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 3]: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. {ECO:0000269|PubMed:34568316}. |
| P41162 | ETV3 | S182 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P41227 | NAA10 | S216 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P43243 | MATR3 | S264 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46013 | MKI67 | S866 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S875 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P50402 | EMD | S98 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P51003 | PAPOLA | S672 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51398 | DAP3 | S185 | psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P54132 | BLM | S358 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54198 | HIRA | S611 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P55042 | RRAD | S214 | psp | GTP-binding protein RAD (RAD1) (Ras associated with diabetes) | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}. |
| P55197 | MLLT10 | S298 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P55210 | CASP7 | S21 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P61978 | HNRNPK | S430 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68104 | EEF1A1 | S83 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P78524 | DENND2B | S522 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q02952 | AKAP12 | S780 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S46 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04727 | TLE4 | S250 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q05086 | UBE3A | S100 | ochoa | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}. |
| Q06945 | SOX4 | S81 | ochoa | Transcription factor SOX-4 | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}. |
| Q07864 | POLE | S1201 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q12774 | ARHGEF5 | S474 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13009 | TIAM1 | S329 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13127 | REST | S1027 | psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13224 | GRIN2B | S1159 | psp | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q13769 | THOC5 | S307 | ochoa|psp | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14151 | SAFB2 | S234 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14517 | FAT1 | S4276 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14676 | MDC1 | S292 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14BN4 | SLMAP | S458 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q14DG7 | TMEM132B | S792 | ochoa | Transmembrane protein 132B | None |
| Q15018 | ABRAXAS2 | S79 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
| Q15021 | NCAPD2 | S608 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15024 | EXOSC7 | S177 | ochoa | Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Q15058 | KIF14 | S1292 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15139 | PRKD1 | S345 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15334 | LLGL1 | S1044 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15361 | TTF1 | S472 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15424 | SAFB | S235 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15554 | TERF2 | S416 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q2TBE0 | CWF19L2 | S454 | ochoa | CWF19-like protein 2 | None |
| Q32MZ4 | LRRFIP1 | S467 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4G163 | FBXO43 | S344 | ochoa | F-box only protein 43 (Endogenous meiotic inhibitor 2) | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}. |
| Q53S48 | STON1-GTF2A1L | S1023 | ochoa | Stonin-1 (Stoned B-like factor) | May be involved in the endocytic machinery. {ECO:0000256|ARBA:ARBA00059680}. |
| Q58DX5 | NAALADL2 | S104 | ochoa | Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2) | May be catalytically inactive. |
| Q5JSH3 | WDR44 | S871 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5QJE6 | DNTTIP2 | S88 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | S239 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T7B8 | KIF24 | S1012 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TH69 | ARFGEF3 | S1848 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5UIP0 | RIF1 | S1760 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VTE0 | EEF1A1P5 | S83 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q63HR2 | TNS2 | S466 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q641Q2 | WASHC2A | S544 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68D51 | DENND2C | S445 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6AZW8 | ZNF660 | S23 | ochoa | Zinc finger protein 660 | May be involved in transcriptional regulation. |
| Q6BDS2 | BLTP3A | S936 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6KC79 | NIPBL | S1089 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P1M3 | LLGL2 | S680 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6P6C2 | ALKBH5 | S375 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6PJF5 | RHBDF2 | S102 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6R327 | RICTOR | S1138 | ochoa|psp | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6VMQ6 | ATF7IP | S403 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6W2J9 | BCOR | S1404 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6WCQ1 | MPRIP | S977 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZU80 | CEP128 | S1033 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q709C8 | VPS13C | S1398 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q71DI3 | H3C15 | S97 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7Z5K2 | WAPL | S380 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z7B0 | FILIP1 | S138 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86U86 | PBRM1 | S987 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VP1 | TAX1BP1 | S691 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VR2 | RETREG3 | S313 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86WJ1 | CHD1L | S628 | ochoa | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34210977, PubMed:34486521, PubMed:34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888). {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:29220653, ECO:0000269|PubMed:33275888, ECO:0000269|PubMed:33357431, ECO:0000269|PubMed:34210977, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. |
| Q8IWU2 | LMTK2 | S601 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N1F7 | NUP93 | S165 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N9T8 | KRI1 | S171 | ochoa | Protein KRI1 homolog | None |
| Q8NAP3 | ZBTB38 | S1166 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NF91 | SYNE1 | S6268 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S2964 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFZ5 | TNIP2 | S186 | ochoa | TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
| Q8TBA6 | GOLGA5 | S453 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TBZ6 | TRMT10A | S28 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
| Q8TC05 | MDM1 | S601 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TCJ2 | STT3B | S498 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). STT3B is present in a small subset of OST complexes (OST-B) and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A (PubMed:19167329, PubMed:22607976, PubMed:31296534, PubMed:39509507). STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins (PubMed:19167329, PubMed:22607976, PubMed:39509507). Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:19167329, PubMed:22607976). Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976). {ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:31296534, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39509507}. |
| Q8TD26 | CHD6 | S1359 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TDM6 | DLG5 | S932 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDX6 | CSGALNACT1 | S90 | ochoa | Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1) | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773, ECO:0000269|PubMed:31705726}. |
| Q8TF76 | HASPIN | S211 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUM0 | NUP133 | S489 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WYP5 | AHCTF1 | S1952 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92543 | SNX19 | S371 | ochoa | Sorting nexin-19 | Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}. |
| Q96H22 | CENPN | S226 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96JJ7 | TMX3 | S433 | ochoa | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) | Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (PubMed:15623505). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:31304984). {ECO:0000269|PubMed:15623505, ECO:0000269|PubMed:31304984}. |
| Q96L91 | EP400 | S928 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96LX8 | ZNF597 | S322 | ochoa | Zinc finger protein 597 | May be involved in transcriptional regulation. |
| Q96M11 | HYLS1 | S147 | ochoa | Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) | Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. |
| Q96RU2 | USP28 | S67 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96T23 | RSF1 | S1310 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99613 | EIF3C | S166 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99613 | EIF3C | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99613 | EIF3C | S529 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99742 | NPAS1 | S478 | ochoa | Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) | May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97459}. |
| Q9BRK0 | REEP2 | S208 | ochoa | Receptor expression-enhancing protein 2 | Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:24388663}. |
| Q9BYW2 | SETD2 | S1888 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZE4 | GTPBP4 | S300 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9GZZ9 | UBA5 | S381 | ochoa | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q9H1E3 | NUCKS1 | S58 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2G9 | BLZF1 | S353 | ochoa | Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) | Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}. |
| Q9H4A3 | WNK1 | S2005 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4L7 | SMARCAD1 | S127 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H6A9 | PCNX3 | S1025 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6Z4 | RANBP3 | S341 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H7P6 | MVB12B | S46 | psp | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. |
| Q9HBM0 | VEZT | S668 | ochoa | Vezatin | Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}. |
| Q9HCB6 | SPON1 | S747 | ochoa | Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) | Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}. |
| Q9HCH5 | SYTL2 | S571 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCK1 | ZDBF2 | S957 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NPG3 | UBN1 | S660 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQW6 | ANLN | S553 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NS56 | TOPORS | S498 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NTZ6 | RBM12 | S375 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NTZ6 | RBM12 | S525 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NZN8 | CNOT2 | S270 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9UHB6 | LIMA1 | S178 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHI6 | DDX20 | S677 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UIG0 | BAZ1B | S705 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKL3 | CASP8AP2 | S29 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S1716 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UN19 | DAPP1 | S137 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9UNF1 | MAGED2 | S70 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UNN4 | GTF2A1L | S319 | ochoa | TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}. |
| Q9Y2W2 | WBP11 | S353 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y3B9 | RRP15 | S85 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y5J1 | UTP18 | S121 | ochoa | U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| O60841 | EIF5B | S178 | Sugiyama | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75534 | CSDE1 | S74 | Sugiyama | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| P05455 | SSB | S83 | Sugiyama | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P07737 | PFN1 | S85 | Sugiyama | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| Q9UNF1 | MAGED2 | S52 | Sugiyama | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| P50897 | PPT1 | S262 | Sugiyama | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.2) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) | Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (PubMed:12855696). {ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:26731412, ECO:0000269|PubMed:8816748}. |
| P50416 | CPT1A | S612 | Sugiyama | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}. |
| Q9GZZ9 | UBA5 | S24 | Sugiyama | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q8TA86 | RP9 | S167 | Sugiyama | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity). {ECO:0000250}. |
| O43813 | LANCL1 | Y21 | Sugiyama | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}. |
| P21802 | FGFR2 | S587 | Sugiyama | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
| P23443 | RPS6KB1 | S75 | Sugiyama | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| Q04864 | REL | S272 | Sugiyama | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| P21980 | TGM2 | S365 | Sugiyama | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P49321 | NASP | S432 | Sugiyama | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| Q8WYR1 | PIK3R5 | S446 | Sugiyama | Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}. |
| O60563 | CCNT1 | S444 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| P54760 | EPHB4 | S735 | Sugiyama | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| Q6XUX3 | DSTYK | S337 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q14566 | MCM6 | S341 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q96RR4 | CAMKK2 | S503 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.000001 | 5.969 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.000002 | 5.643 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.000016 | 4.806 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.000018 | 4.753 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.000387 | 3.412 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 0.000449 | 3.348 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.000861 | 3.065 |
| R-HSA-1640170 | Cell Cycle | 0.000850 | 3.071 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.001083 | 2.965 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.001208 | 2.918 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.001626 | 2.789 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001795 | 2.746 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001795 | 2.746 |
| R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 0.002123 | 2.673 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.002589 | 2.587 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.002452 | 2.610 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.002375 | 2.624 |
| R-HSA-68886 | M Phase | 0.003269 | 2.486 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 0.003799 | 2.420 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.004152 | 2.382 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.004044 | 2.393 |
| R-HSA-68882 | Mitotic Anaphase | 0.004827 | 2.316 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.004958 | 2.305 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.005489 | 2.260 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.006088 | 2.215 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.006304 | 2.200 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.006924 | 2.160 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.008127 | 2.090 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.007427 | 2.129 |
| R-HSA-68877 | Mitotic Prometaphase | 0.008175 | 2.088 |
| R-HSA-109704 | PI3K Cascade | 0.007989 | 2.097 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.009375 | 2.028 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.009110 | 2.040 |
| R-HSA-73886 | Chromosome Maintenance | 0.010093 | 1.996 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.011826 | 1.927 |
| R-HSA-112399 | IRS-mediated signalling | 0.011733 | 1.931 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.013013 | 1.886 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.013154 | 1.881 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.013481 | 1.870 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.013809 | 1.860 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.014304 | 1.845 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 0.015383 | 1.813 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.014998 | 1.824 |
| R-HSA-190236 | Signaling by FGFR | 0.016175 | 1.791 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.016449 | 1.784 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.016449 | 1.784 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.017206 | 1.764 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.017507 | 1.757 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.019747 | 1.705 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.019747 | 1.705 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.021710 | 1.663 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.021792 | 1.662 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 0.022100 | 1.656 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.022207 | 1.654 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.026351 | 1.579 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.026351 | 1.579 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.026351 | 1.579 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.026351 | 1.579 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.026351 | 1.579 |
| R-HSA-3642279 | TGFBR2 MSI Frameshift Mutants in Cancer | 0.026351 | 1.579 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.025711 | 1.590 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.028315 | 1.548 |
| R-HSA-4839726 | Chromatin organization | 0.029230 | 1.534 |
| R-HSA-162587 | HIV Life Cycle | 0.031168 | 1.506 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.029805 | 1.526 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.028986 | 1.538 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.031218 | 1.506 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.032578 | 1.487 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.032578 | 1.487 |
| R-HSA-774815 | Nucleosome assembly | 0.034814 | 1.458 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.034814 | 1.458 |
| R-HSA-68875 | Mitotic Prophase | 0.034966 | 1.456 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.035448 | 1.450 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.039267 | 1.406 |
| R-HSA-8853333 | Signaling by FGFR2 fusions | 0.039267 | 1.406 |
| R-HSA-1500620 | Meiosis | 0.037030 | 1.431 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.037859 | 1.422 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.039910 | 1.399 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.038412 | 1.416 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.052011 | 1.284 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.052011 | 1.284 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.052011 | 1.284 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.076998 | 1.114 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.089245 | 1.049 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.089245 | 1.049 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.101330 | 0.994 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.113255 | 0.946 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.159401 | 0.798 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.181569 | 0.741 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.072595 | 1.139 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.072595 | 1.139 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.072595 | 1.139 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.076409 | 1.117 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.076409 | 1.117 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.084222 | 1.075 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.088216 | 1.054 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.088216 | 1.054 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.096368 | 1.016 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.096368 | 1.016 |
| R-HSA-390522 | Striated Muscle Contraction | 0.100522 | 0.998 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.100522 | 0.998 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.049191 | 1.308 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.104725 | 0.980 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.108975 | 0.963 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.244644 | 0.611 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.254675 | 0.594 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.061586 | 1.211 |
| R-HSA-191859 | snRNP Assembly | 0.061586 | 1.211 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.126406 | 0.898 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.126406 | 0.898 |
| R-HSA-3928664 | Ephrin signaling | 0.264574 | 0.577 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.264574 | 0.577 |
| R-HSA-167169 | HIV Transcription Elongation | 0.130862 | 0.883 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.130862 | 0.883 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.130862 | 0.883 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.130862 | 0.883 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.130862 | 0.883 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.130862 | 0.883 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.274342 | 0.562 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.274342 | 0.562 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.283981 | 0.547 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.283981 | 0.547 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.283981 | 0.547 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.283981 | 0.547 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.293492 | 0.532 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.095421 | 1.020 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.162966 | 0.788 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.302878 | 0.519 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.302878 | 0.519 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.302878 | 0.519 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.312139 | 0.506 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.321278 | 0.493 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.321278 | 0.493 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.120382 | 0.919 |
| R-HSA-72187 | mRNA 3'-end processing | 0.191467 | 0.718 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.191467 | 0.718 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.196282 | 0.707 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.339195 | 0.470 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.205955 | 0.686 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.356642 | 0.448 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.356642 | 0.448 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.365192 | 0.437 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.365192 | 0.437 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.067707 | 1.169 |
| R-HSA-72172 | mRNA Splicing | 0.081576 | 1.088 |
| R-HSA-167172 | Transcription of the HIV genome | 0.269667 | 0.569 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.274590 | 0.561 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.279511 | 0.554 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.113270 | 0.946 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.084222 | 1.075 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.167663 | 0.776 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.213736 | 0.670 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.104725 | 0.980 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.104725 | 0.980 |
| R-HSA-157579 | Telomere Maintenance | 0.176269 | 0.754 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.224176 | 0.649 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.139880 | 0.854 |
| R-HSA-3214842 | HDMs demethylate histones | 0.065162 | 1.186 |
| R-HSA-9831926 | Nephron development | 0.264574 | 0.577 |
| R-HSA-180786 | Extension of Telomeres | 0.225444 | 0.647 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.362223 | 0.441 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.048956 | 1.310 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.312139 | 0.506 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.365192 | 0.437 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.224176 | 0.649 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.113255 | 0.946 |
| R-HSA-162592 | Integration of provirus | 0.181569 | 0.741 |
| R-HSA-4641265 | Repression of WNT target genes | 0.192434 | 0.716 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.283981 | 0.547 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.284430 | 0.546 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.299164 | 0.524 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.203156 | 0.692 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.064828 | 1.188 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.330296 | 0.481 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.244644 | 0.611 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.111810 | 0.952 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.339195 | 0.470 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.328469 | 0.484 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.177255 | 0.751 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.203156 | 0.692 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.312139 | 0.506 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.061586 | 1.211 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.089245 | 1.049 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.244644 | 0.611 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.237780 | 0.624 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.333324 | 0.477 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.136635 | 0.864 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.159401 | 0.798 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.264744 | 0.577 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.192434 | 0.716 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.135354 | 0.869 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.302878 | 0.519 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.347826 | 0.459 |
| R-HSA-3000170 | Syndecan interactions | 0.058006 | 1.237 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.225444 | 0.647 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.220286 | 0.657 |
| R-HSA-5693538 | Homology Directed Repair | 0.259071 | 0.587 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.101330 | 0.994 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.101330 | 0.994 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.125022 | 0.903 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.125022 | 0.903 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.136635 | 0.864 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.148093 | 0.829 |
| R-HSA-176974 | Unwinding of DNA | 0.148093 | 0.829 |
| R-HSA-68952 | DNA replication initiation | 0.159401 | 0.798 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.203156 | 0.692 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.224176 | 0.649 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.066011 | 1.180 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.264574 | 0.577 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.080123 | 1.096 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.158294 | 0.801 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.321278 | 0.493 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.330296 | 0.481 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.330296 | 0.481 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.330296 | 0.481 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.356642 | 0.448 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.235242 | 0.628 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.318732 | 0.497 |
| R-HSA-9694614 | Attachment and Entry | 0.051149 | 1.291 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.153647 | 0.813 |
| R-HSA-9609646 | HCMV Infection | 0.293855 | 0.532 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.259821 | 0.585 |
| R-HSA-162906 | HIV Infection | 0.115277 | 0.938 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.117608 | 0.930 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.264574 | 0.577 |
| R-HSA-9620244 | Long-term potentiation | 0.339195 | 0.470 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.191467 | 0.718 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.159401 | 0.798 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.213736 | 0.670 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.092266 | 1.035 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.100522 | 0.998 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.092793 | 1.032 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.312139 | 0.506 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.158294 | 0.801 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.264574 | 0.577 |
| R-HSA-9610379 | HCMV Late Events | 0.086984 | 1.061 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.321278 | 0.493 |
| R-HSA-525793 | Myogenesis | 0.347976 | 0.458 |
| R-HSA-8953854 | Metabolism of RNA | 0.067764 | 1.169 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.089245 | 1.049 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.113255 | 0.946 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.148093 | 0.829 |
| R-HSA-164843 | 2-LTR circle formation | 0.159401 | 0.798 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.170559 | 0.768 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.181569 | 0.741 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.072595 | 1.139 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.203156 | 0.692 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.274342 | 0.562 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.365192 | 0.437 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.352638 | 0.453 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.347976 | 0.458 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.057306 | 1.242 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.172383 | 0.764 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.101330 | 0.994 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.136635 | 0.864 |
| R-HSA-912446 | Meiotic recombination | 0.186668 | 0.729 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.330296 | 0.481 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.308961 | 0.510 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.136635 | 0.864 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.104725 | 0.980 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.112618 | 0.948 |
| R-HSA-114608 | Platelet degranulation | 0.295052 | 0.530 |
| R-HSA-73894 | DNA Repair | 0.070624 | 1.151 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.055717 | 1.254 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.293492 | 0.532 |
| R-HSA-390651 | Dopamine receptors | 0.076998 | 1.114 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.089245 | 1.049 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.159401 | 0.798 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.224176 | 0.649 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.130862 | 0.883 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.135354 | 0.869 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.302878 | 0.519 |
| R-HSA-429947 | Deadenylation of mRNA | 0.330296 | 0.481 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.299164 | 0.524 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.304066 | 0.517 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.159401 | 0.798 |
| R-HSA-75153 | Apoptotic execution phase | 0.162966 | 0.788 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.148093 | 0.829 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.170559 | 0.768 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.084222 | 1.075 |
| R-HSA-8876725 | Protein methylation | 0.224176 | 0.649 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.244644 | 0.611 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.302878 | 0.519 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.320434 | 0.494 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.264574 | 0.577 |
| R-HSA-69481 | G2/M Checkpoints | 0.295052 | 0.530 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.089245 | 1.049 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.148093 | 0.829 |
| R-HSA-448706 | Interleukin-1 processing | 0.148093 | 0.829 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.234478 | 0.630 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.121987 | 0.914 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.162966 | 0.788 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.225444 | 0.647 |
| R-HSA-2024096 | HS-GAG degradation | 0.092266 | 1.035 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.254675 | 0.594 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.264574 | 0.577 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.213736 | 0.670 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.224176 | 0.649 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.126406 | 0.898 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.264574 | 0.577 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.312139 | 0.506 |
| R-HSA-1221632 | Meiotic synapsis | 0.196282 | 0.707 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.347976 | 0.458 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.114810 | 0.940 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.172383 | 0.764 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.192434 | 0.716 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.220557 | 0.656 |
| R-HSA-8939211 | ESR-mediated signaling | 0.260797 | 0.584 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.264574 | 0.577 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.293492 | 0.532 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.302878 | 0.519 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.210812 | 0.676 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.365192 | 0.437 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.240150 | 0.620 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.309359 | 0.510 |
| R-HSA-2559583 | Cellular Senescence | 0.129533 | 0.888 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.072595 | 1.139 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.302878 | 0.519 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.113270 | 0.946 |
| R-HSA-186712 | Regulation of beta-cell development | 0.225444 | 0.647 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.240150 | 0.620 |
| R-HSA-9833110 | RSV-host interactions | 0.203076 | 0.692 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.284430 | 0.546 |
| R-HSA-72306 | tRNA processing | 0.246838 | 0.608 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.092793 | 1.032 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.108975 | 0.963 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.046273 | 1.335 |
| R-HSA-200425 | Carnitine shuttle | 0.321278 | 0.493 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.279511 | 0.554 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.357437 | 0.447 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.330296 | 0.481 |
| R-HSA-1474165 | Reproduction | 0.133006 | 0.876 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.333324 | 0.477 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.181569 | 0.741 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.279511 | 0.554 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.068845 | 1.162 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.192434 | 0.716 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.339195 | 0.470 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.312139 | 0.506 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.152302 | 0.817 |
| R-HSA-3371556 | Cellular response to heat stress | 0.269813 | 0.569 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.114141 | 0.943 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.220557 | 0.656 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.318732 | 0.497 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.360328 | 0.443 |
| R-HSA-73942 | DNA Damage Reversal | 0.224176 | 0.649 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.304066 | 0.517 |
| R-HSA-166520 | Signaling by NTRKs | 0.073263 | 1.135 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.229347 | 0.640 |
| R-HSA-449836 | Other interleukin signaling | 0.274342 | 0.562 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.294257 | 0.531 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.131153 | 0.882 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.274342 | 0.562 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.321278 | 0.493 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.356443 | 0.448 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.339195 | 0.470 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.339195 | 0.470 |
| R-HSA-211000 | Gene Silencing by RNA | 0.213365 | 0.671 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.298672 | 0.525 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.225374 | 0.647 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.132684 | 0.877 |
| R-HSA-622312 | Inflammasomes | 0.365192 | 0.437 |
| R-HSA-9679506 | SARS-CoV Infections | 0.363532 | 0.439 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.048956 | 1.310 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.221516 | 0.655 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.324447 | 0.489 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.362223 | 0.441 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.345841 | 0.461 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.233425 | 0.632 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.366996 | 0.435 |
| R-HSA-5334118 | DNA methylation | 0.373629 | 0.428 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.373629 | 0.428 |
| R-HSA-72086 | mRNA Capping | 0.373629 | 0.428 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.373629 | 0.428 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.373629 | 0.428 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.373629 | 0.428 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.373629 | 0.428 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.373629 | 0.428 |
| R-HSA-73884 | Base Excision Repair | 0.381231 | 0.419 |
| R-HSA-2424491 | DAP12 signaling | 0.381955 | 0.418 |
| R-HSA-69242 | S Phase | 0.381968 | 0.418 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.381968 | 0.418 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.385946 | 0.413 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.389148 | 0.410 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.390170 | 0.409 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.390170 | 0.409 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.390170 | 0.409 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.390646 | 0.408 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.395330 | 0.403 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.396307 | 0.402 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.398277 | 0.400 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.398277 | 0.400 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.398277 | 0.400 |
| R-HSA-69190 | DNA strand elongation | 0.398277 | 0.400 |
| R-HSA-69306 | DNA Replication | 0.399879 | 0.398 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.399997 | 0.398 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.403445 | 0.394 |
| R-HSA-73887 | Death Receptor Signaling | 0.403445 | 0.394 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.404204 | 0.393 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.406277 | 0.391 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.406277 | 0.391 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.406277 | 0.391 |
| R-HSA-9930044 | Nuclear RNA decay | 0.406277 | 0.391 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.406277 | 0.391 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.406277 | 0.391 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.406277 | 0.391 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.406277 | 0.391 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.406277 | 0.391 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.406277 | 0.391 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.407005 | 0.390 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.409281 | 0.388 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.414170 | 0.383 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.414170 | 0.383 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.421960 | 0.375 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.421960 | 0.375 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.421960 | 0.375 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.421960 | 0.375 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.421960 | 0.375 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.422662 | 0.374 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.423074 | 0.374 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.427635 | 0.369 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.427635 | 0.369 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.427635 | 0.369 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.429646 | 0.367 |
| R-HSA-381042 | PERK regulates gene expression | 0.429646 | 0.367 |
| R-HSA-3214847 | HATs acetylate histones | 0.432177 | 0.364 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.432177 | 0.364 |
| R-HSA-72312 | rRNA processing | 0.434515 | 0.362 |
| R-HSA-70171 | Glycolysis | 0.436701 | 0.360 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.437230 | 0.359 |
| R-HSA-3371511 | HSF1 activation | 0.437230 | 0.359 |
| R-HSA-111933 | Calmodulin induced events | 0.437230 | 0.359 |
| R-HSA-111997 | CaM pathway | 0.437230 | 0.359 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.437230 | 0.359 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.437230 | 0.359 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.437230 | 0.359 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.441204 | 0.355 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.444714 | 0.352 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.444714 | 0.352 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.444714 | 0.352 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 0.444714 | 0.352 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.444714 | 0.352 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.444714 | 0.352 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.445688 | 0.351 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.445688 | 0.351 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.445688 | 0.351 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.452099 | 0.345 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.452099 | 0.345 |
| R-HSA-73927 | Depurination | 0.452099 | 0.345 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.459019 | 0.338 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.459019 | 0.338 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.459386 | 0.338 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.462975 | 0.334 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.463421 | 0.334 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.463421 | 0.334 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.466577 | 0.331 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.466577 | 0.331 |
| R-HSA-202433 | Generation of second messenger molecules | 0.466577 | 0.331 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.466577 | 0.331 |
| R-HSA-5260271 | Diseases of Immune System | 0.466577 | 0.331 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.466577 | 0.331 |
| R-HSA-9824446 | Viral Infection Pathways | 0.466641 | 0.331 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.469817 | 0.328 |
| R-HSA-69239 | Synthesis of DNA | 0.472163 | 0.326 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.473672 | 0.325 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.473672 | 0.325 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.473672 | 0.325 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.473672 | 0.325 |
| R-HSA-9694548 | Maturation of spike protein | 0.473672 | 0.325 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.473672 | 0.325 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.473672 | 0.325 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.476502 | 0.322 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.476502 | 0.322 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.480674 | 0.318 |
| R-HSA-167161 | HIV Transcription Initiation | 0.480674 | 0.318 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.480674 | 0.318 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.480674 | 0.318 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.480674 | 0.318 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.480674 | 0.318 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.480819 | 0.318 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.485114 | 0.314 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.485114 | 0.314 |
| R-HSA-165159 | MTOR signalling | 0.487583 | 0.312 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.487583 | 0.312 |
| R-HSA-111996 | Ca-dependent events | 0.487583 | 0.312 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.487583 | 0.312 |
| R-HSA-73928 | Depyrimidination | 0.487583 | 0.312 |
| R-HSA-168255 | Influenza Infection | 0.493451 | 0.307 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.493639 | 0.307 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.494400 | 0.306 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.494400 | 0.306 |
| R-HSA-9710421 | Defective pyroptosis | 0.494400 | 0.306 |
| R-HSA-74160 | Gene expression (Transcription) | 0.495324 | 0.305 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.497868 | 0.303 |
| R-HSA-2172127 | DAP12 interactions | 0.501127 | 0.300 |
| R-HSA-5683826 | Surfactant metabolism | 0.501127 | 0.300 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.501127 | 0.300 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.501127 | 0.300 |
| R-HSA-5688426 | Deubiquitination | 0.501133 | 0.300 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.506722 | 0.295 |
| R-HSA-162582 | Signal Transduction | 0.507288 | 0.295 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.507765 | 0.294 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.507765 | 0.294 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.507765 | 0.294 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.507765 | 0.294 |
| R-HSA-3781865 | Diseases of glycosylation | 0.510012 | 0.292 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.510419 | 0.292 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.514315 | 0.289 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.514315 | 0.289 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.514315 | 0.289 |
| R-HSA-9675135 | Diseases of DNA repair | 0.514315 | 0.289 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.514315 | 0.289 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.514315 | 0.289 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.514315 | 0.289 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.518672 | 0.285 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.518672 | 0.285 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.520778 | 0.283 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.522764 | 0.282 |
| R-HSA-70326 | Glucose metabolism | 0.522764 | 0.282 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.523056 | 0.281 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.530878 | 0.275 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.530878 | 0.275 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.532714 | 0.274 |
| R-HSA-73893 | DNA Damage Bypass | 0.533449 | 0.273 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.533449 | 0.273 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.535909 | 0.271 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.539092 | 0.268 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.542873 | 0.265 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.542873 | 0.265 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.545787 | 0.263 |
| R-HSA-9609690 | HCMV Early Events | 0.548566 | 0.261 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.551833 | 0.258 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.551833 | 0.258 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.551833 | 0.258 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.551833 | 0.258 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.557799 | 0.254 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.557799 | 0.254 |
| R-HSA-72766 | Translation | 0.557932 | 0.253 |
| R-HSA-69206 | G1/S Transition | 0.558534 | 0.253 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.561020 | 0.251 |
| R-HSA-72649 | Translation initiation complex formation | 0.563686 | 0.249 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.563686 | 0.249 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.563686 | 0.249 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.569495 | 0.245 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.569495 | 0.245 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.575228 | 0.240 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.575228 | 0.240 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.575228 | 0.240 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.575228 | 0.240 |
| R-HSA-75893 | TNF signaling | 0.575228 | 0.240 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.575228 | 0.240 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.580884 | 0.236 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.586465 | 0.232 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.586465 | 0.232 |
| R-HSA-9909396 | Circadian clock | 0.588701 | 0.230 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.597406 | 0.224 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.597406 | 0.224 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.597406 | 0.224 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.597406 | 0.224 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.597406 | 0.224 |
| R-HSA-397014 | Muscle contraction | 0.600034 | 0.222 |
| R-HSA-450294 | MAP kinase activation | 0.602769 | 0.220 |
| R-HSA-112043 | PLC beta mediated events | 0.602769 | 0.220 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.602940 | 0.220 |
| R-HSA-1268020 | Mitochondrial protein import | 0.608060 | 0.216 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.608060 | 0.216 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.608060 | 0.216 |
| R-HSA-6799198 | Complex I biogenesis | 0.613281 | 0.212 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.613281 | 0.212 |
| R-HSA-195721 | Signaling by WNT | 0.615292 | 0.211 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.618432 | 0.209 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.623516 | 0.205 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.628532 | 0.202 |
| R-HSA-9830369 | Kidney development | 0.633481 | 0.198 |
| R-HSA-112040 | G-protein mediated events | 0.633481 | 0.198 |
| R-HSA-109582 | Hemostasis | 0.636629 | 0.196 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.638365 | 0.195 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.644393 | 0.191 |
| R-HSA-2187338 | Visual phototransduction | 0.647669 | 0.189 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.647939 | 0.188 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.647939 | 0.188 |
| R-HSA-448424 | Interleukin-17 signaling | 0.647939 | 0.188 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.647939 | 0.188 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.652631 | 0.185 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.652631 | 0.185 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.652631 | 0.185 |
| R-HSA-8978934 | Metabolism of cofactors | 0.652631 | 0.185 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.657261 | 0.182 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.657355 | 0.182 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.661829 | 0.179 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.663694 | 0.178 |
| R-HSA-9609507 | Protein localization | 0.666828 | 0.176 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.668460 | 0.175 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.669938 | 0.174 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.670785 | 0.173 |
| R-HSA-1989781 | PPARA activates gene expression | 0.673025 | 0.172 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.675174 | 0.171 |
| R-HSA-5689603 | UCH proteinases | 0.675174 | 0.171 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.675174 | 0.171 |
| R-HSA-9612973 | Autophagy | 0.676089 | 0.170 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.679129 | 0.168 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.679505 | 0.168 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.682146 | 0.166 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.683778 | 0.165 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.683778 | 0.165 |
| R-HSA-216083 | Integrin cell surface interactions | 0.683778 | 0.165 |
| R-HSA-4086400 | PCP/CE pathway | 0.683778 | 0.165 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.688112 | 0.162 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.688112 | 0.162 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.692155 | 0.160 |
| R-HSA-109581 | Apoptosis | 0.693985 | 0.159 |
| R-HSA-977225 | Amyloid fiber formation | 0.696260 | 0.157 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.700311 | 0.155 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.704308 | 0.152 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.708252 | 0.150 |
| R-HSA-5619102 | SLC transporter disorders | 0.708271 | 0.150 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.712144 | 0.147 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.715984 | 0.145 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.719772 | 0.143 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.721999 | 0.141 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.723511 | 0.141 |
| R-HSA-156902 | Peptide chain elongation | 0.727200 | 0.138 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.727200 | 0.138 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.730182 | 0.137 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.732587 | 0.135 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.734432 | 0.134 |
| R-HSA-2262752 | Cellular responses to stress | 0.737358 | 0.132 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.737976 | 0.132 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.744923 | 0.128 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.748327 | 0.126 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.758272 | 0.120 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.761499 | 0.118 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.761499 | 0.118 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.763867 | 0.117 |
| R-HSA-9658195 | Leishmania infection | 0.767401 | 0.115 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.767401 | 0.115 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.767826 | 0.115 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.767826 | 0.115 |
| R-HSA-1280218 | Adaptive Immune System | 0.769064 | 0.114 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.769341 | 0.114 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.779981 | 0.108 |
| R-HSA-1483255 | PI Metabolism | 0.779981 | 0.108 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.782920 | 0.106 |
| R-HSA-111885 | Opioid Signalling | 0.785820 | 0.105 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.785820 | 0.105 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.786575 | 0.104 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.794289 | 0.100 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.797038 | 0.099 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.797038 | 0.099 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.797038 | 0.099 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.799749 | 0.097 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.799749 | 0.097 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.802425 | 0.096 |
| R-HSA-5357801 | Programmed Cell Death | 0.803558 | 0.095 |
| R-HSA-202403 | TCR signaling | 0.805065 | 0.094 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.810241 | 0.091 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.812777 | 0.090 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.815280 | 0.089 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.817080 | 0.088 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.817749 | 0.087 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.822589 | 0.085 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.822589 | 0.085 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.822589 | 0.085 |
| R-HSA-5663205 | Infectious disease | 0.832263 | 0.080 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.834417 | 0.079 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.836355 | 0.078 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.841659 | 0.075 |
| R-HSA-1643685 | Disease | 0.841747 | 0.075 |
| R-HSA-977606 | Regulation of Complement cascade | 0.844937 | 0.073 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.847011 | 0.072 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.847011 | 0.072 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.847011 | 0.072 |
| R-HSA-194138 | Signaling by VEGF | 0.847011 | 0.072 |
| R-HSA-1474244 | Extracellular matrix organization | 0.849311 | 0.071 |
| R-HSA-212436 | Generic Transcription Pathway | 0.850368 | 0.070 |
| R-HSA-157118 | Signaling by NOTCH | 0.863218 | 0.064 |
| R-HSA-449147 | Signaling by Interleukins | 0.864832 | 0.063 |
| R-HSA-597592 | Post-translational protein modification | 0.866142 | 0.062 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.871593 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.872963 | 0.059 |
| R-HSA-5173105 | O-linked glycosylation | 0.873313 | 0.059 |
| R-HSA-5368287 | Mitochondrial translation | 0.875009 | 0.058 |
| R-HSA-422475 | Axon guidance | 0.876518 | 0.057 |
| R-HSA-6807070 | PTEN Regulation | 0.876683 | 0.057 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.878334 | 0.056 |
| R-HSA-9664407 | Parasite infection | 0.878334 | 0.056 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.878334 | 0.056 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.879964 | 0.056 |
| R-HSA-166658 | Complement cascade | 0.887791 | 0.052 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.888567 | 0.051 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.896516 | 0.047 |
| R-HSA-9675108 | Nervous system development | 0.907510 | 0.042 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.907672 | 0.042 |
| R-HSA-913531 | Interferon Signaling | 0.907672 | 0.042 |
| R-HSA-418555 | G alpha (s) signalling events | 0.922065 | 0.035 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.924143 | 0.034 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.924143 | 0.034 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.924143 | 0.034 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.924143 | 0.034 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.924143 | 0.034 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.925161 | 0.034 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.926166 | 0.033 |
| R-HSA-8978868 | Fatty acid metabolism | 0.926673 | 0.033 |
| R-HSA-611105 | Respiratory electron transport | 0.929099 | 0.032 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.936368 | 0.029 |
| R-HSA-983712 | Ion channel transport | 0.938898 | 0.027 |
| R-HSA-392499 | Metabolism of proteins | 0.939079 | 0.027 |
| R-HSA-5668914 | Diseases of metabolism | 0.939703 | 0.027 |
| R-HSA-5617833 | Cilium Assembly | 0.939719 | 0.027 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.944419 | 0.025 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.944548 | 0.025 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.947348 | 0.023 |
| R-HSA-428157 | Sphingolipid metabolism | 0.948056 | 0.023 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.949444 | 0.023 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.949444 | 0.023 |
| R-HSA-1266738 | Developmental Biology | 0.952557 | 0.021 |
| R-HSA-6798695 | Neutrophil degranulation | 0.955296 | 0.020 |
| R-HSA-388396 | GPCR downstream signalling | 0.956684 | 0.019 |
| R-HSA-418990 | Adherens junctions interactions | 0.959294 | 0.018 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.959664 | 0.018 |
| R-HSA-112316 | Neuronal System | 0.960007 | 0.018 |
| R-HSA-8951664 | Neddylation | 0.960916 | 0.017 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.964933 | 0.016 |
| R-HSA-421270 | Cell-cell junction organization | 0.973984 | 0.011 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.975603 | 0.011 |
| R-HSA-372790 | Signaling by GPCR | 0.978524 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 0.979027 | 0.009 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.979350 | 0.009 |
| R-HSA-199991 | Membrane Trafficking | 0.979642 | 0.009 |
| R-HSA-446728 | Cell junction organization | 0.981976 | 0.008 |
| R-HSA-1483257 | Phospholipid metabolism | 0.985699 | 0.006 |
| R-HSA-168249 | Innate Immune System | 0.987815 | 0.005 |
| R-HSA-1500931 | Cell-Cell communication | 0.989258 | 0.005 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.989828 | 0.004 |
| R-HSA-168256 | Immune System | 0.991950 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992363 | 0.003 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.996034 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.997515 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.997654 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999964 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
TGFBR1 |
0.796 | 0.698 | -2 | 0.587 |
BMPR1B |
0.795 | 0.573 | 1 | 0.866 |
BMPR1A |
0.792 | 0.625 | 1 | 0.872 |
ALK2 |
0.789 | 0.713 | -2 | 0.549 |
ALK4 |
0.781 | 0.670 | -2 | 0.542 |
ACVR2B |
0.779 | 0.525 | -2 | 0.493 |
ACVR2A |
0.779 | 0.519 | -2 | 0.510 |
TGFBR2 |
0.779 | 0.465 | -2 | 0.524 |
COT |
0.776 | 0.115 | 2 | 0.679 |
CLK3 |
0.774 | 0.160 | 1 | 0.788 |
CAMK2G |
0.772 | 0.202 | 2 | 0.781 |
CDC7 |
0.771 | 0.153 | 1 | 0.897 |
GRK1 |
0.770 | 0.128 | -2 | 0.176 |
DSTYK |
0.768 | 0.165 | 2 | 0.696 |
CAMK2B |
0.767 | 0.194 | 2 | 0.760 |
MOS |
0.765 | 0.135 | 1 | 0.861 |
GCN2 |
0.763 | 0.124 | 2 | 0.674 |
GRK7 |
0.760 | 0.168 | 1 | 0.768 |
NDR2 |
0.759 | 0.052 | -3 | 0.815 |
CAMK2A |
0.759 | 0.169 | 2 | 0.802 |
GRK6 |
0.759 | 0.132 | 1 | 0.834 |
IKKB |
0.758 | -0.048 | -2 | 0.145 |
FAM20C |
0.757 | 0.049 | 2 | 0.458 |
CK2A2 |
0.757 | 0.229 | 1 | 0.765 |
IKKA |
0.757 | 0.032 | -2 | 0.169 |
PIM3 |
0.757 | 0.001 | -3 | 0.816 |
NEK6 |
0.756 | 0.086 | -2 | 0.293 |
BMPR2 |
0.756 | 0.322 | -2 | 0.283 |
PLK1 |
0.756 | 0.173 | -2 | 0.335 |
PRPK |
0.756 | -0.019 | -1 | 0.817 |
GRK5 |
0.755 | 0.039 | -3 | 0.847 |
LATS2 |
0.754 | 0.112 | -5 | 0.727 |
CAMK2D |
0.753 | 0.082 | -3 | 0.831 |
PLK3 |
0.753 | 0.164 | 2 | 0.652 |
GRK4 |
0.751 | 0.074 | -2 | 0.245 |
NEK7 |
0.751 | 0.044 | -3 | 0.865 |
RSK2 |
0.751 | 0.010 | -3 | 0.750 |
KIS |
0.750 | 0.012 | 1 | 0.596 |
ULK2 |
0.750 | -0.082 | 2 | 0.615 |
RAF1 |
0.749 | -0.081 | 1 | 0.771 |
MAPKAPK2 |
0.749 | 0.048 | -3 | 0.714 |
CAMK1B |
0.749 | -0.041 | -3 | 0.850 |
MTOR |
0.748 | -0.076 | 1 | 0.687 |
TBK1 |
0.748 | -0.052 | 1 | 0.644 |
CLK2 |
0.747 | 0.099 | -3 | 0.727 |
PDHK4 |
0.747 | -0.133 | 1 | 0.759 |
PIM1 |
0.747 | 0.024 | -3 | 0.762 |
ATM |
0.747 | 0.094 | 1 | 0.716 |
ATR |
0.746 | -0.023 | 1 | 0.743 |
GRK2 |
0.746 | 0.059 | -2 | 0.243 |
ULK1 |
0.745 | -0.058 | -3 | 0.849 |
IKKE |
0.745 | -0.067 | 1 | 0.647 |
CK2A1 |
0.745 | 0.191 | 1 | 0.740 |
TLK2 |
0.743 | 0.229 | 1 | 0.709 |
CDKL1 |
0.742 | -0.027 | -3 | 0.793 |
PDHK1 |
0.742 | -0.127 | 1 | 0.739 |
LATS1 |
0.742 | 0.092 | -3 | 0.825 |
PKN3 |
0.742 | -0.048 | -3 | 0.818 |
SRPK2 |
0.741 | 0.047 | -3 | 0.658 |
PRKX |
0.741 | 0.023 | -3 | 0.643 |
SRPK1 |
0.741 | 0.020 | -3 | 0.731 |
P90RSK |
0.740 | -0.022 | -3 | 0.755 |
PRKD1 |
0.740 | -0.036 | -3 | 0.800 |
GRK3 |
0.740 | 0.067 | -2 | 0.262 |
NDR1 |
0.740 | -0.053 | -3 | 0.812 |
RSK4 |
0.739 | 0.013 | -3 | 0.720 |
HUNK |
0.739 | -0.092 | 2 | 0.616 |
AURC |
0.739 | -0.056 | -2 | 0.076 |
MARK4 |
0.738 | -0.069 | 4 | 0.750 |
TLK1 |
0.738 | 0.243 | -2 | 0.394 |
NIK |
0.738 | -0.110 | -3 | 0.870 |
NLK |
0.738 | -0.113 | 1 | 0.722 |
ERK5 |
0.737 | -0.099 | 1 | 0.699 |
CHAK2 |
0.737 | -0.090 | -1 | 0.797 |
PKACB |
0.737 | -0.021 | -2 | 0.079 |
PLK2 |
0.736 | 0.147 | -3 | 0.822 |
CAMLCK |
0.735 | -0.090 | -2 | 0.148 |
MLK1 |
0.735 | -0.104 | 2 | 0.638 |
DAPK2 |
0.735 | -0.086 | -3 | 0.853 |
MST4 |
0.735 | -0.089 | 2 | 0.688 |
PKCD |
0.735 | -0.062 | 2 | 0.646 |
AURA |
0.734 | -0.049 | -2 | 0.094 |
CDK8 |
0.734 | -0.036 | 1 | 0.577 |
SRPK3 |
0.734 | 0.036 | -3 | 0.711 |
PRKD2 |
0.734 | -0.049 | -3 | 0.753 |
CDKL5 |
0.734 | -0.056 | -3 | 0.780 |
DNAPK |
0.734 | 0.080 | 1 | 0.625 |
RSK3 |
0.734 | -0.046 | -3 | 0.749 |
SKMLCK |
0.734 | -0.099 | -2 | 0.127 |
CLK4 |
0.734 | 0.032 | -3 | 0.741 |
P70S6KB |
0.734 | -0.057 | -3 | 0.778 |
TTBK2 |
0.734 | -0.084 | 2 | 0.570 |
PKACG |
0.733 | -0.083 | -2 | 0.087 |
MSK1 |
0.733 | -0.011 | -3 | 0.725 |
ICK |
0.733 | -0.057 | -3 | 0.825 |
MSK2 |
0.733 | -0.035 | -3 | 0.722 |
ANKRD3 |
0.733 | -0.048 | 1 | 0.737 |
DLK |
0.733 | -0.097 | 1 | 0.747 |
WNK1 |
0.732 | -0.128 | -2 | 0.097 |
MAPKAPK3 |
0.732 | -0.066 | -3 | 0.756 |
NUAK2 |
0.732 | -0.098 | -3 | 0.821 |
BCKDK |
0.731 | -0.116 | -1 | 0.743 |
PERK |
0.731 | 0.156 | -2 | 0.364 |
NEK9 |
0.730 | -0.136 | 2 | 0.658 |
MASTL |
0.729 | -0.211 | -2 | 0.152 |
CLK1 |
0.729 | 0.027 | -3 | 0.723 |
CDK1 |
0.729 | -0.005 | 1 | 0.572 |
BRAF |
0.728 | 0.050 | -4 | 0.772 |
YSK4 |
0.728 | -0.076 | 1 | 0.679 |
MLK3 |
0.728 | -0.072 | 2 | 0.601 |
AURB |
0.727 | -0.077 | -2 | 0.079 |
HIPK4 |
0.727 | -0.084 | 1 | 0.674 |
MEK1 |
0.727 | -0.071 | 2 | 0.661 |
CHK1 |
0.727 | 0.003 | -3 | 0.810 |
MLK4 |
0.727 | -0.033 | 2 | 0.574 |
PKN2 |
0.727 | -0.132 | -3 | 0.816 |
TSSK2 |
0.726 | -0.101 | -5 | 0.800 |
CDK19 |
0.726 | -0.047 | 1 | 0.541 |
PAK1 |
0.726 | -0.104 | -2 | 0.085 |
NIM1 |
0.725 | -0.119 | 3 | 0.762 |
PKR |
0.725 | -0.068 | 1 | 0.728 |
RIPK3 |
0.724 | -0.199 | 3 | 0.730 |
AMPKA1 |
0.723 | -0.118 | -3 | 0.830 |
HRI |
0.723 | 0.077 | -2 | 0.333 |
PKACA |
0.722 | -0.040 | -2 | 0.065 |
JNK3 |
0.721 | -0.024 | 1 | 0.576 |
PLK4 |
0.721 | -0.059 | 2 | 0.490 |
MLK2 |
0.721 | -0.194 | 2 | 0.634 |
CAMK4 |
0.721 | -0.137 | -3 | 0.801 |
PKCG |
0.721 | -0.101 | 2 | 0.596 |
QSK |
0.721 | -0.079 | 4 | 0.715 |
CDK5 |
0.721 | -0.025 | 1 | 0.611 |
JNK2 |
0.720 | -0.023 | 1 | 0.538 |
WNK3 |
0.720 | -0.254 | 1 | 0.701 |
MARK3 |
0.720 | -0.072 | 4 | 0.678 |
PASK |
0.720 | 0.029 | -3 | 0.833 |
CDK18 |
0.719 | -0.032 | 1 | 0.526 |
TSSK1 |
0.719 | -0.106 | -3 | 0.845 |
NUAK1 |
0.719 | -0.090 | -3 | 0.776 |
IRE2 |
0.719 | -0.061 | 2 | 0.578 |
DCAMKL1 |
0.719 | 0.010 | -3 | 0.758 |
MNK1 |
0.719 | -0.095 | -2 | 0.104 |
PKCB |
0.718 | -0.090 | 2 | 0.587 |
CDK13 |
0.718 | -0.049 | 1 | 0.564 |
DRAK1 |
0.718 | -0.086 | 1 | 0.721 |
SIK |
0.718 | -0.079 | -3 | 0.743 |
PKCA |
0.718 | -0.096 | 2 | 0.587 |
MARK2 |
0.718 | -0.076 | 4 | 0.639 |
NEK2 |
0.718 | -0.148 | 2 | 0.631 |
PAK6 |
0.718 | -0.096 | -2 | 0.062 |
PKG2 |
0.718 | -0.102 | -2 | 0.065 |
MNK2 |
0.718 | -0.115 | -2 | 0.097 |
DYRK2 |
0.718 | -0.060 | 1 | 0.604 |
MYLK4 |
0.718 | -0.091 | -2 | 0.096 |
PIM2 |
0.718 | -0.039 | -3 | 0.727 |
PAK3 |
0.717 | -0.153 | -2 | 0.081 |
GSK3A |
0.717 | 0.030 | 4 | 0.471 |
BRSK1 |
0.717 | -0.072 | -3 | 0.772 |
CDK2 |
0.716 | -0.046 | 1 | 0.653 |
IRE1 |
0.716 | -0.145 | 1 | 0.662 |
AMPKA2 |
0.716 | -0.109 | -3 | 0.796 |
P38B |
0.716 | -0.039 | 1 | 0.556 |
VRK2 |
0.715 | -0.244 | 1 | 0.756 |
CDK17 |
0.715 | -0.033 | 1 | 0.493 |
PHKG1 |
0.715 | -0.058 | -3 | 0.803 |
DCAMKL2 |
0.715 | 0.000 | -3 | 0.788 |
PKCH |
0.715 | -0.115 | 2 | 0.571 |
MARK1 |
0.714 | -0.091 | 4 | 0.701 |
MEKK3 |
0.714 | -0.117 | 1 | 0.696 |
QIK |
0.714 | -0.165 | -3 | 0.819 |
P38G |
0.714 | -0.023 | 1 | 0.483 |
EEF2K |
0.714 | 0.081 | 3 | 0.811 |
SMG1 |
0.714 | -0.078 | 1 | 0.686 |
PAK2 |
0.714 | -0.143 | -2 | 0.087 |
CK1E |
0.714 | -0.039 | -3 | 0.520 |
ERK1 |
0.714 | -0.052 | 1 | 0.532 |
CDK3 |
0.713 | -0.005 | 1 | 0.512 |
P38A |
0.713 | -0.067 | 1 | 0.601 |
PRKD3 |
0.713 | -0.090 | -3 | 0.723 |
SGK3 |
0.713 | -0.088 | -3 | 0.732 |
CDK16 |
0.713 | -0.017 | 1 | 0.508 |
CDK7 |
0.713 | -0.075 | 1 | 0.590 |
PINK1 |
0.712 | -0.121 | 1 | 0.696 |
CAMK1G |
0.712 | -0.085 | -3 | 0.752 |
MAPKAPK5 |
0.711 | -0.096 | -3 | 0.709 |
ZAK |
0.711 | -0.116 | 1 | 0.671 |
AKT2 |
0.711 | -0.063 | -3 | 0.667 |
PRP4 |
0.711 | -0.046 | -3 | 0.740 |
CHAK1 |
0.711 | -0.181 | 2 | 0.578 |
GSK3B |
0.711 | -0.000 | 4 | 0.456 |
DYRK4 |
0.710 | -0.029 | 1 | 0.543 |
RIPK1 |
0.710 | -0.271 | 1 | 0.682 |
HIPK2 |
0.710 | -0.040 | 1 | 0.518 |
TTBK1 |
0.710 | -0.094 | 2 | 0.518 |
PKCZ |
0.709 | -0.147 | 2 | 0.604 |
MELK |
0.709 | -0.153 | -3 | 0.781 |
NEK5 |
0.709 | -0.090 | 1 | 0.702 |
MEKK1 |
0.709 | -0.132 | 1 | 0.689 |
CDK12 |
0.709 | -0.055 | 1 | 0.538 |
MST2 |
0.708 | -0.023 | 1 | 0.727 |
CAMKK1 |
0.708 | -0.140 | -2 | 0.112 |
HIPK1 |
0.708 | -0.061 | 1 | 0.608 |
MEKK2 |
0.708 | -0.131 | 2 | 0.627 |
P38D |
0.708 | -0.032 | 1 | 0.484 |
TAO3 |
0.707 | -0.083 | 1 | 0.694 |
SMMLCK |
0.707 | -0.096 | -3 | 0.805 |
BRSK2 |
0.707 | -0.117 | -3 | 0.797 |
ERK2 |
0.706 | -0.076 | 1 | 0.572 |
CK1D |
0.706 | -0.032 | -3 | 0.472 |
DAPK3 |
0.706 | -0.051 | -3 | 0.778 |
CAMK1D |
0.705 | -0.043 | -3 | 0.670 |
MEK5 |
0.705 | -0.240 | 2 | 0.639 |
CDK9 |
0.705 | -0.075 | 1 | 0.566 |
SNRK |
0.705 | -0.200 | 2 | 0.528 |
DYRK1A |
0.704 | -0.068 | 1 | 0.633 |
CAMKK2 |
0.703 | -0.138 | -2 | 0.104 |
GAK |
0.703 | -0.054 | 1 | 0.732 |
NEK8 |
0.703 | -0.114 | 2 | 0.636 |
P70S6K |
0.703 | -0.085 | -3 | 0.689 |
DYRK1B |
0.702 | -0.058 | 1 | 0.575 |
CDK14 |
0.702 | -0.063 | 1 | 0.563 |
JNK1 |
0.702 | -0.031 | 1 | 0.549 |
DAPK1 |
0.701 | -0.056 | -3 | 0.758 |
AKT1 |
0.701 | -0.078 | -3 | 0.681 |
MST3 |
0.701 | -0.149 | 2 | 0.648 |
PHKG2 |
0.700 | -0.121 | -3 | 0.774 |
TTK |
0.700 | 0.158 | -2 | 0.372 |
CK1G1 |
0.700 | -0.064 | -3 | 0.518 |
PAK5 |
0.700 | -0.116 | -2 | 0.056 |
SSTK |
0.699 | -0.122 | 4 | 0.699 |
GCK |
0.699 | -0.082 | 1 | 0.715 |
TAO2 |
0.698 | -0.123 | 2 | 0.677 |
PAK4 |
0.698 | -0.106 | -2 | 0.068 |
MST1 |
0.698 | -0.052 | 1 | 0.697 |
TAK1 |
0.698 | -0.062 | 1 | 0.735 |
CK1A2 |
0.698 | -0.048 | -3 | 0.469 |
WNK4 |
0.698 | -0.204 | -2 | 0.107 |
PKCT |
0.697 | -0.135 | 2 | 0.581 |
ERK7 |
0.697 | -0.048 | 2 | 0.447 |
HIPK3 |
0.697 | -0.097 | 1 | 0.591 |
DYRK3 |
0.696 | -0.074 | 1 | 0.605 |
CDK10 |
0.696 | -0.054 | 1 | 0.548 |
PDHK3_TYR |
0.696 | 0.187 | 4 | 0.854 |
PKCI |
0.695 | -0.133 | 2 | 0.586 |
MAK |
0.694 | -0.038 | -2 | 0.078 |
MPSK1 |
0.693 | -0.128 | 1 | 0.634 |
SGK1 |
0.693 | -0.047 | -3 | 0.584 |
MRCKA |
0.693 | -0.068 | -3 | 0.734 |
TNIK |
0.693 | -0.088 | 3 | 0.818 |
NEK11 |
0.693 | -0.213 | 1 | 0.686 |
PKCE |
0.693 | -0.095 | 2 | 0.577 |
IRAK4 |
0.692 | -0.219 | 1 | 0.661 |
LKB1 |
0.691 | -0.171 | -3 | 0.840 |
HGK |
0.691 | -0.114 | 3 | 0.818 |
SLK |
0.691 | -0.116 | -2 | 0.107 |
PDK1 |
0.691 | -0.146 | 1 | 0.683 |
AKT3 |
0.691 | -0.065 | -3 | 0.601 |
MINK |
0.690 | -0.132 | 1 | 0.683 |
MAP2K6_TYR |
0.690 | 0.173 | -1 | 0.844 |
LRRK2 |
0.690 | -0.189 | 2 | 0.667 |
NEK4 |
0.690 | -0.184 | 1 | 0.666 |
STK33 |
0.689 | -0.134 | 2 | 0.511 |
MEK2 |
0.689 | -0.137 | 2 | 0.629 |
MRCKB |
0.689 | -0.083 | -3 | 0.715 |
PDHK4_TYR |
0.689 | 0.126 | 2 | 0.715 |
CAMK1A |
0.688 | -0.071 | -3 | 0.639 |
PDHK1_TYR |
0.687 | 0.125 | -1 | 0.856 |
HPK1 |
0.687 | -0.127 | 1 | 0.697 |
NEK1 |
0.687 | -0.146 | 1 | 0.670 |
CDK6 |
0.687 | -0.061 | 1 | 0.533 |
ALPHAK3 |
0.686 | 0.003 | -1 | 0.748 |
MAP2K4_TYR |
0.686 | 0.108 | -1 | 0.845 |
DMPK1 |
0.686 | -0.041 | -3 | 0.740 |
MAP3K15 |
0.685 | -0.187 | 1 | 0.648 |
YANK3 |
0.685 | -0.038 | 2 | 0.361 |
SBK |
0.685 | -0.034 | -3 | 0.555 |
BMPR2_TYR |
0.685 | 0.046 | -1 | 0.849 |
ROCK2 |
0.684 | -0.090 | -3 | 0.756 |
LOK |
0.684 | -0.173 | -2 | 0.097 |
EPHA4 |
0.683 | 0.144 | 2 | 0.647 |
KHS1 |
0.683 | -0.103 | 1 | 0.681 |
IRAK1 |
0.683 | -0.257 | -1 | 0.682 |
CHK2 |
0.683 | -0.063 | -3 | 0.612 |
KHS2 |
0.683 | -0.081 | 1 | 0.696 |
CDK4 |
0.683 | -0.068 | 1 | 0.529 |
OSR1 |
0.682 | -0.053 | 2 | 0.620 |
PKN1 |
0.682 | -0.115 | -3 | 0.703 |
EPHA6 |
0.682 | 0.091 | -1 | 0.823 |
VRK1 |
0.681 | -0.221 | 2 | 0.631 |
MEKK6 |
0.681 | -0.233 | 1 | 0.678 |
PKG1 |
0.680 | -0.114 | -2 | 0.045 |
TESK1_TYR |
0.679 | -0.079 | 3 | 0.854 |
MAP2K7_TYR |
0.679 | -0.071 | 2 | 0.693 |
YSK1 |
0.678 | -0.162 | 2 | 0.638 |
MOK |
0.677 | -0.077 | 1 | 0.611 |
RIPK2 |
0.676 | -0.224 | 1 | 0.625 |
TXK |
0.676 | 0.130 | 1 | 0.816 |
BIKE |
0.675 | -0.028 | 1 | 0.602 |
BUB1 |
0.675 | -0.101 | -5 | 0.741 |
PBK |
0.674 | -0.116 | 1 | 0.647 |
SRMS |
0.674 | 0.121 | 1 | 0.847 |
PINK1_TYR |
0.674 | -0.113 | 1 | 0.741 |
CK1A |
0.674 | -0.043 | -3 | 0.381 |
EPHB4 |
0.674 | 0.019 | -1 | 0.789 |
PKMYT1_TYR |
0.673 | -0.114 | 3 | 0.822 |
EPHB2 |
0.673 | 0.111 | -1 | 0.769 |
ROCK1 |
0.672 | -0.096 | -3 | 0.726 |
FER |
0.672 | 0.067 | 1 | 0.852 |
NEK3 |
0.671 | -0.175 | 1 | 0.617 |
INSRR |
0.669 | 0.044 | 3 | 0.728 |
EPHB1 |
0.669 | 0.059 | 1 | 0.828 |
CRIK |
0.669 | -0.065 | -3 | 0.686 |
HASPIN |
0.669 | -0.063 | -1 | 0.678 |
MYO3A |
0.669 | -0.138 | 1 | 0.669 |
YES1 |
0.668 | 0.011 | -1 | 0.791 |
ASK1 |
0.667 | -0.163 | 1 | 0.642 |
BLK |
0.667 | 0.091 | -1 | 0.788 |
EPHA5 |
0.667 | 0.126 | 2 | 0.628 |
EPHB3 |
0.667 | 0.055 | -1 | 0.765 |
SYK |
0.666 | 0.114 | -1 | 0.756 |
MYO3B |
0.665 | -0.155 | 2 | 0.642 |
EPHA7 |
0.665 | 0.070 | 2 | 0.634 |
PTK2 |
0.664 | 0.081 | -1 | 0.784 |
FYN |
0.664 | 0.071 | -1 | 0.762 |
FGR |
0.664 | -0.050 | 1 | 0.758 |
TYK2 |
0.663 | -0.141 | 1 | 0.695 |
LIMK2_TYR |
0.663 | -0.175 | -3 | 0.884 |
HCK |
0.662 | 0.003 | -1 | 0.765 |
EPHA3 |
0.662 | 0.017 | 2 | 0.631 |
LCK |
0.662 | 0.035 | -1 | 0.771 |
AAK1 |
0.662 | -0.002 | 1 | 0.500 |
RET |
0.661 | -0.158 | 1 | 0.694 |
TAO1 |
0.661 | -0.155 | 1 | 0.609 |
LIMK1_TYR |
0.661 | -0.205 | 2 | 0.673 |
STLK3 |
0.660 | -0.145 | 1 | 0.643 |
ROS1 |
0.660 | -0.110 | 3 | 0.734 |
EPHA8 |
0.660 | 0.079 | -1 | 0.757 |
ABL2 |
0.660 | -0.035 | -1 | 0.746 |
FGFR2 |
0.659 | -0.019 | 3 | 0.781 |
JAK2 |
0.659 | -0.133 | 1 | 0.684 |
TEC |
0.659 | 0.052 | -1 | 0.658 |
MST1R |
0.659 | -0.161 | 3 | 0.773 |
JAK3 |
0.659 | -0.073 | 1 | 0.679 |
TYRO3 |
0.659 | -0.126 | 3 | 0.758 |
CSF1R |
0.658 | -0.089 | 3 | 0.761 |
EGFR |
0.658 | 0.053 | 1 | 0.637 |
ITK |
0.658 | -0.007 | -1 | 0.721 |
FLT1 |
0.657 | 0.016 | -1 | 0.804 |
KIT |
0.656 | -0.044 | 3 | 0.764 |
DDR1 |
0.656 | -0.166 | 4 | 0.755 |
FRK |
0.655 | 0.024 | -1 | 0.771 |
ABL1 |
0.655 | -0.062 | -1 | 0.737 |
ERBB2 |
0.654 | -0.018 | 1 | 0.711 |
NTRK1 |
0.654 | -0.034 | -1 | 0.759 |
MERTK |
0.654 | -0.029 | 3 | 0.751 |
YANK2 |
0.654 | -0.052 | 2 | 0.375 |
BMX |
0.654 | -0.004 | -1 | 0.646 |
EPHA2 |
0.653 | 0.091 | -1 | 0.725 |
KDR |
0.653 | -0.085 | 3 | 0.739 |
CK1G2 |
0.653 | 0.003 | -3 | 0.434 |
FLT3 |
0.653 | -0.091 | 3 | 0.757 |
TEK |
0.652 | -0.063 | 3 | 0.705 |
PTK2B |
0.652 | 0.021 | -1 | 0.701 |
FGFR3 |
0.652 | -0.011 | 3 | 0.753 |
PDGFRB |
0.652 | -0.127 | 3 | 0.772 |
TNK2 |
0.652 | -0.095 | 3 | 0.731 |
LYN |
0.651 | 0.006 | 3 | 0.690 |
MET |
0.651 | -0.053 | 3 | 0.753 |
LTK |
0.650 | -0.073 | 3 | 0.723 |
FGFR1 |
0.650 | -0.089 | 3 | 0.742 |
SRC |
0.650 | 0.012 | -1 | 0.759 |
CK1G3 |
0.649 | -0.044 | -3 | 0.335 |
ERBB4 |
0.648 | 0.048 | 1 | 0.697 |
PTK6 |
0.648 | -0.071 | -1 | 0.643 |
JAK1 |
0.647 | -0.127 | 1 | 0.631 |
NEK10_TYR |
0.647 | -0.122 | 1 | 0.563 |
ALK |
0.647 | -0.101 | 3 | 0.702 |
BTK |
0.646 | -0.094 | -1 | 0.666 |
FLT4 |
0.646 | -0.071 | 3 | 0.732 |
FGFR4 |
0.646 | 0.009 | -1 | 0.730 |
EPHA1 |
0.646 | -0.053 | 3 | 0.731 |
NTRK3 |
0.646 | -0.033 | -1 | 0.709 |
TNNI3K_TYR |
0.645 | -0.136 | 1 | 0.673 |
INSR |
0.645 | -0.075 | 3 | 0.694 |
AXL |
0.645 | -0.128 | 3 | 0.745 |
NTRK2 |
0.645 | -0.083 | 3 | 0.727 |
MATK |
0.644 | -0.056 | -1 | 0.688 |
PDGFRA |
0.643 | -0.195 | 3 | 0.768 |
TNK1 |
0.640 | -0.194 | 3 | 0.741 |
CSK |
0.640 | -0.071 | 2 | 0.642 |
WEE1_TYR |
0.640 | -0.138 | -1 | 0.674 |
IGF1R |
0.639 | -0.019 | 3 | 0.641 |
DDR2 |
0.636 | -0.119 | 3 | 0.727 |
MUSK |
0.630 | -0.068 | 1 | 0.623 |
ZAP70 |
0.625 | -0.009 | -1 | 0.670 |
FES |
0.625 | -0.044 | -1 | 0.629 |