Motif 563 (n=260)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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A8MSY1 | STIMATE-MUSTN1 | S268 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
H0YHG0 | None | S146 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
O00533 | CHL1 | S1127 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
O14647 | CHD2 | S130 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
O15234 | CASC3 | S126 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
O15240 | VGF | S420 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
O15397 | IPO8 | S903 | ochoa | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
O43719 | HTATSF1 | S481 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
O60293 | ZFC3H1 | S1046 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
O75116 | ROCK2 | S937 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
O75410 | TACC1 | S218 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
O75410 | TACC1 | S576 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
O75420 | GIGYF1 | S443 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O94880 | PHF14 | S84 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
O95197 | RTN3 | S560 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
O95218 | ZRANB2 | S120 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
P02730 | SLC4A1 | S29 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
P04920 | SLC4A2 | S65 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
P05060 | CHGB | S380 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
P05114 | HMGN1 | T81 | ochoa | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
P05120 | SERPINB2 | S136 | ochoa | Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor) | Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. |
P10645 | CHGA | S113 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
P12956 | XRCC6 | S237 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
P15374 | UCHL3 | S151 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
P15374 | UCHL3 | S161 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
P16383 | GCFC2 | S40 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
P16389 | KCNA2 | Y132 | psp | Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11211111, PubMed:19912772, PubMed:23769686, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20220134, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). {ECO:0000250|UniProtKB:P63141, ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:32833227, ECO:0000269|PubMed:35439054, ECO:0000269|PubMed:37883018, ECO:0000269|PubMed:8495559, ECO:0000305}. |
P17980 | PSMC3 | S37 | ochoa | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
P19237 | TNNI1 | S169 | ochoa | Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
P19338 | NCL | S41 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
P19338 | NCL | S496 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
P22059 | OSBP | S193 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
P24593 | IGFBP5 | S125 | ochoa | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}. |
P24821 | TNC | S86 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
P27824 | CANX | S554 | ochoa|psp | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
P31749 | AKT1 | S129 | ochoa|psp | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960, PubMed:29343641, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915, PubMed:12172553). Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 (PubMed:31548394, PubMed:33594058). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (By similarity). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF1 (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (PubMed:30504268). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:30504268, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}. |
P35222 | CTNNB1 | S646 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
P35609 | ACTN2 | S433 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
P39880 | CUX1 | S1357 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
P40337 | VHL | S38 | psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
P40425 | PBX2 | S105 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
P41214 | EIF2D | S237 | ochoa | Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) | Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}. |
P42566 | EPS15 | S595 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
P43003 | SLC1A3 | S512 | ochoa | Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}. |
P43355 | MAGEA1 | S82 | ochoa | Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen) | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}. |
P46100 | ATRX | S1326 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46821 | MAP1B | Y1170 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P48426 | PIP4K2A | S304 | psp | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}. |
P49321 | NASP | S189 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
P49792 | RANBP2 | S2925 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P50851 | LRBA | S1118 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
P51858 | HDGF | S132 | ochoa|psp | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
P52565 | ARHGDIA | S34 | ochoa|psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
P52597 | HNRNPF | S186 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
P54132 | BLM | S282 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
P55087 | AQP4 | S276 | ochoa|psp | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
P57768 | SNX16 | S299 | ochoa | Sorting nexin-16 | May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}. |
P63104 | YWHAZ | S99 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
P78527 | PRKDC | S3365 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
Q00341 | HDLBP | S622 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
Q01082 | SPTBN1 | S825 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
Q02224 | CENPE | S2513 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
Q02410 | APBA1 | Y264 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
Q03188 | CENPC | S679 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
Q05682 | CALD1 | Y160 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
Q07617 | SPAG1 | S347 | ochoa | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
Q08499 | PDE4D | S754 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
Q08AD1 | CAMSAP2 | S496 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
Q0ZGT2 | NEXN | S160 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
Q0ZGT2 | NEXN | S218 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
Q12983 | BNIP3 | S93 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
Q13029 | PRDM2 | S1118 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
Q13129 | RLF | S1277 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
Q13277 | STX3 | S207 | ochoa | Syntaxin-3 | Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}. |
Q13426 | XRCC4 | S232 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
Q13428 | TCOF1 | S484 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q13433 | SLC39A6 | S478 | ochoa | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}. |
Q13435 | SF3B2 | S307 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
Q13435 | SF3B2 | S309 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
Q13459 | MYO9B | S1972 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
Q13523 | PRP4K | S23 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
Q13610 | PWP1 | S50 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
Q13610 | PWP1 | S57 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
Q14126 | DSG2 | S782 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
Q14151 | SAFB2 | S234 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14152 | EIF3A | S1198 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
Q14160 | SCRIB | S688 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14515 | SPARCL1 | S231 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
Q14515 | SPARCL1 | S414 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
Q14761 | PTPRCAP | S153 | psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
Q14789 | GOLGB1 | S538 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
Q14978 | NOLC1 | S432 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
Q15149 | PLEC | S1554 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q15149 | PLEC | S4054 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q15233 | NONO | S262 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
Q15424 | SAFB | S235 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
Q16643 | DBN1 | S601 | ochoa|psp | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
Q2TBE0 | CWF19L2 | S454 | ochoa | CWF19-like protein 2 | None |
Q5FWF6 | ZNF789 | S146 | ochoa | Zinc finger protein 789 | May be involved in transcriptional regulation. |
Q5H9R7 | PPP6R3 | S666 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
Q5JRA6 | MIA3 | S407 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
Q5JSH3 | WDR44 | S66 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
Q5R3F8 | ELFN2 | S530 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
Q5SSJ5 | HP1BP3 | S446 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
Q5SYE7 | NHSL1 | S166 | ochoa | NHS-like protein 1 | None |
Q5T5X7 | BEND3 | S36 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
Q5UIP0 | RIF1 | S2393 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q5VT52 | RPRD2 | S356 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q5VWN6 | TASOR2 | S1172 | ochoa | Protein TASOR 2 | None |
Q5VZL5 | ZMYM4 | S1071 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Q63HN8 | RNF213 | S3525 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
Q63HQ0 | AP1AR | S226 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
Q641Q2 | WASHC2A | S619 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q6IBW4 | NCAPH2 | S466 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
Q6KC79 | NIPBL | S2491 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
Q6NWY9 | PRPF40B | S852 | ochoa | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}. |
Q6P158 | DHX57 | S132 | ochoa | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
Q6PJT7 | ZC3H14 | S268 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
Q6PL18 | ATAD2 | S1302 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
Q6QNY0 | BLOC1S3 | S33 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
Q6UN15 | FIP1L1 | S500 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
Q6Y2X3 | DNAJC14 | S516 | ochoa | DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) | Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}. |
Q6ZT12 | UBR3 | S1053 | ochoa | E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). {ECO:0000250|UniProtKB:Q5U430, ECO:0000269|PubMed:27331610}. |
Q6ZUM4 | ARHGAP27 | S481 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
Q70CQ2 | USP34 | S3359 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
Q70J99 | UNC13D | S1029 | ochoa | Protein unc-13 homolog D (Munc13-4) | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}. |
Q71RC2 | LARP4 | S74 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
Q76I76 | SSH2 | S690 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
Q7L014 | DDX46 | S295 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
Q7L0Y3 | TRMT10C | S73 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
Q7L8S5 | OTUD6A | S74 | psp | OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2) | Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. {ECO:0000269|PubMed:23827681}. |
Q7LG56 | RRM2B | S20 | ochoa | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}. |
Q7RTP6 | MICAL3 | S1512 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q7Z2K8 | GPRIN1 | S134 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z2K8 | GPRIN1 | S381 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z591 | AKNA | S40 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
Q7Z6E9 | RBBP6 | S245 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
Q7Z6E9 | RBBP6 | S246 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
Q86T82 | USP37 | S457 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
Q86T82 | USP37 | S770 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
Q86TL2 | STIMATE | S268 | ochoa | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. |
Q86X53 | ERICH1 | S339 | ochoa | Glutamate-rich protein 1 | None |
Q86XK7 | VSIG1 | S306 | ochoa | V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34) | None |
Q8IUW5 | RELL1 | S109 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
Q8IWV8 | UBR2 | S171 | ochoa | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:20835242, PubMed:28392261). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (PubMed:38225265). {ECO:0000250|UniProtKB:Q6WKZ8, ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0000269|PubMed:38225265}. |
Q8IWZ3 | ANKHD1 | S208 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
Q8IXT5 | RBM12B | S829 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
Q8IY92 | SLX4 | S287 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
Q8IYB3 | SRRM1 | S234 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q8IYW5 | RNF168 | S134 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
Q8IYW5 | RNF168 | S174 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
Q8N108 | MIER1 | S53 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
Q8N163 | CCAR2 | S681 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
Q8N3C0 | ASCC3 | S452 | ochoa | Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
Q8N3V7 | SYNPO | S263 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N573 | OXR1 | S354 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
Q8N960 | CEP120 | S935 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
Q8NG31 | KNL1 | S634 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
Q8TAQ2 | SMARCC2 | S841 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q8TCU6 | PREX1 | S1169 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
Q8TDJ6 | DMXL2 | S1288 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
Q8WU90 | ZC3H15 | S381 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
Q8WVC0 | LEO1 | S212 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
Q8WWI1 | LMO7 | S1388 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q8WXI2 | CNKSR2 | S687 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
Q8WYP5 | AHCTF1 | S1541 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
Q92551 | IP6K1 | S145 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
Q92610 | ZNF592 | S1205 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
Q92614 | MYO18A | S35 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
Q92766 | RREB1 | S1598 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
Q92889 | ERCC4 | S524 | ochoa | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}. |
Q92932 | PTPRN2 | S436 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
Q96BT3 | CENPT | S343 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
Q96CC6 | RHBDF1 | S283 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
Q96CT7 | CCDC124 | S155 | ochoa | Coiled-coil domain-containing protein 124 | Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:32687489}. |
Q96G23 | CERS2 | S349 | ochoa|psp | Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297) | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity). {ECO:0000250|UniProtKB:Q924Z4, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:19728861, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}. |
Q96GA3 | LTV1 | S331 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
Q96GA3 | LTV1 | S355 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
Q96JG6 | VPS50 | S546 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
Q96JW4 | SLC41A2 | S137 | ochoa | Solute carrier family 41 member 2 | Acts as a plasma-membrane magnesium transporter (PubMed:16984228). Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (By similarity). {ECO:0000250|UniProtKB:Q8BYR8, ECO:0000269|PubMed:16984228}. |
Q96PN7 | TRERF1 | S975 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
Q96PY6 | NEK1 | S1126 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
Q96QT4 | TRPM7 | S1191 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
Q96RV3 | PCNX1 | S485 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
Q96SB4 | SRPK1 | S555 | psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
Q96SI9 | STRBP | S474 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
Q99700 | ATXN2 | S479 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
Q99742 | NPAS1 | S478 | ochoa | Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) | May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97459}. |
Q9BQS8 | FYCO1 | S609 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
Q9BRP8 | PYM1 | S117 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
Q9BTC0 | DIDO1 | S809 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BTC0 | DIDO1 | T1432 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BUR4 | WRAP53 | S112 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
Q9BV36 | MLPH | S403 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BW71 | HIRIP3 | S142 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
Q9BYW2 | SETD2 | S1988 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9BZF1 | OSBPL8 | S364 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
Q9C0C2 | TNKS1BP1 | S1008 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9GZR1 | SENP6 | S55 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
Q9GZU2 | PEG3 | S222 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
Q9H063 | MAF1 | S238 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
Q9H0E9 | BRD8 | S610 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Q9H0X9 | OSBPL5 | S327 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
Q9H1E5 | TMX4 | S251 | ochoa | Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13) | None |
Q9H2P0 | ADNP | S921 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
Q9H3Z4 | DNAJC5 | S177 | ochoa | DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}. |
Q9H444 | CHMP4B | S184 | ochoa | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:33349255}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. |
Q9H501 | ESF1 | S180 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
Q9H6S1 | AZI2 | S83 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
Q9H8V3 | ECT2 | S40 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
Q9HA82 | CERS4 | S349 | psp | Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) | Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
Q9HAU0 | PLEKHA5 | S822 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
Q9HCC9 | ZFYVE28 | S394 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
Q9NUQ6 | SPATS2L | S135 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
Q9NW97 | TMEM51 | S133 | ochoa | Transmembrane protein 51 | None |
Q9NWQ8 | PAG1 | S301 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
Q9NXV6 | CDKN2AIP | S151 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
Q9NXX6 | NSMCE4A | S63 | ochoa | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
Q9NYF8 | BCLAF1 | S198 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
Q9NZ71 | RTEL1 | S882 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
Q9NZV7 | ZIM2 | S97 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
Q9P2D1 | CHD7 | S2255 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
Q9P2R6 | RERE | S56 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
Q9UBW5 | BIN2 | S331 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
Q9UGY1 | NOL12 | S139 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
Q9UH99 | SUN2 | S84 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
Q9UHB6 | LIMA1 | S326 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
Q9UHB7 | AFF4 | S694 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
Q9UIG0 | BAZ1B | S161 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
Q9UJY4 | GGA2 | S233 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
Q9UKJ3 | GPATCH8 | S1107 | ochoa | G patch domain-containing protein 8 | None |
Q9UKL3 | CASP8AP2 | S1667 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
Q9UKL3 | CASP8AP2 | S1674 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
Q9UKY1 | ZHX1 | S639 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
Q9UKY1 | ZHX1 | S640 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
Q9UPN6 | SCAF8 | S779 | ochoa | SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
Q9UPQ0 | LIMCH1 | S435 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UPQ7 | PDZRN3 | S825 | ochoa | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}. |
Q9UQL6 | HDAC5 | S611 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
Q9Y2I9 | TBC1D30 | S30 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
Q9Y3E1 | HDGFL3 | S178 | ochoa | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}. |
Q9Y3X0 | CCDC9 | S60 | ochoa | Coiled-coil domain-containing protein 9 | Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}. |
Q9Y6P5 | SESN1 | S314 | ochoa | Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26) | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}. |
V9GYY5 | None | S132 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
Q04695 | KRT17 | S277 | Sugiyama | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}. |
Q8IZ69 | TRMT2A | S480 | Sugiyama | tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}. |
Q9H2G2 | SLK | S362 | Sugiyama | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
Q6UB35 | MTHFD1L | S401 | Sugiyama | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
P23396 | RPS3 | S35 | Sugiyama | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
P42167 | TMPO | S167 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
P61163 | ACTR1A | S247 | Sugiyama | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
O96013 | PAK4 | S41 | Sugiyama | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
P18206 | VCL | S1101 | GPS6|SIGNOR|ELM|EPSD | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
P09960 | LTA4H | S236 | Sugiyama | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
Q9UNN4 | GTF2A1L | S357 | SIGNOR|ELM|iPTMNet | TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}. |
Q9NPI1 | BRD7 | S336 | Sugiyama | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
P14868 | DARS1 | S369 | Sugiyama | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}. |
Q96RT6 | CTAGE1 | Y76 | Sugiyama | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
Q13428 | TCOF1 | S341 | Sugiyama | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
P07711 | CTSL | S301 | Sugiyama | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07154, ECO:0000250|UniProtKB:P25975, ECO:0000269|PubMed:10716919, ECO:0000305}.; FUNCTION: (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell (PubMed:16339146, PubMed:18562523, PubMed:32142651, PubMed:32221306, PubMed:37990007). Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins (PubMed:16081529, PubMed:18562523, PubMed:26953343). {ECO:0000269|PubMed:16081529, ECO:0000269|PubMed:16339146, ECO:0000269|PubMed:18562523, ECO:0000269|PubMed:26953343, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:37990007}.; FUNCTION: [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor (PubMed:15099520). Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties (PubMed:15099520). {ECO:0000269|PubMed:15099520}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.002488 | 2.604 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.004909 | 2.309 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.004909 | 2.309 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.004659 | 2.332 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.000609 | 3.215 |
R-HSA-73886 | Chromosome Maintenance | 0.001940 | 2.712 |
R-HSA-1640170 | Cell Cycle | 0.004754 | 2.323 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.005616 | 2.251 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.009768 | 2.010 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.009246 | 2.034 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.010607 | 1.974 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.011232 | 1.950 |
R-HSA-72172 | mRNA Splicing | 0.012492 | 1.903 |
R-HSA-164843 | 2-LTR circle formation | 0.019674 | 1.706 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.018982 | 1.722 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.016204 | 1.790 |
R-HSA-9766229 | Degradation of CDH1 | 0.015036 | 1.823 |
R-HSA-68882 | Mitotic Anaphase | 0.016931 | 1.771 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.017347 | 1.761 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.019244 | 1.716 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.014390 | 1.842 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.015585 | 1.807 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.017530 | 1.756 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.016469 | 1.783 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.022575 | 1.646 |
R-HSA-425381 | Bicarbonate transporters | 0.022575 | 1.646 |
R-HSA-447115 | Interleukin-12 family signaling | 0.021886 | 1.660 |
R-HSA-180786 | Extension of Telomeres | 0.025334 | 1.596 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.024980 | 1.602 |
R-HSA-162592 | Integration of provirus | 0.025641 | 1.591 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.025278 | 1.597 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.027007 | 1.569 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.028797 | 1.541 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.032259 | 1.491 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.032259 | 1.491 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.032259 | 1.491 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.032259 | 1.491 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.032259 | 1.491 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.031851 | 1.497 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.033138 | 1.480 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.035767 | 1.447 |
R-HSA-157579 | Telomere Maintenance | 0.033797 | 1.471 |
R-HSA-68886 | M Phase | 0.035583 | 1.449 |
R-HSA-9682385 | FLT3 signaling in disease | 0.034535 | 1.462 |
R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.047998 | 1.319 |
R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.078714 | 1.104 |
R-HSA-209563 | Axonal growth stimulation | 0.078714 | 1.104 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.108443 | 0.965 |
R-HSA-5619062 | Defective SLC1A3 causes episodic ataxia 6 (EA6) | 0.108443 | 0.965 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.122947 | 0.910 |
R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.122947 | 0.910 |
R-HSA-447041 | CHL1 interactions | 0.151254 | 0.820 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.151254 | 0.820 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.151254 | 0.820 |
R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.165064 | 0.782 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.165064 | 0.782 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.178651 | 0.748 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.073207 | 1.135 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.073207 | 1.135 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.205166 | 0.688 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.082709 | 1.082 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.218102 | 0.661 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.092564 | 1.034 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.230829 | 0.637 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.230829 | 0.637 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.230829 | 0.637 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.230829 | 0.637 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.230829 | 0.637 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.230829 | 0.637 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.243349 | 0.614 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.057540 | 1.240 |
R-HSA-774815 | Nucleosome assembly | 0.057540 | 1.240 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.267783 | 0.572 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.267783 | 0.572 |
R-HSA-72187 | mRNA 3'-end processing | 0.076978 | 1.114 |
R-HSA-390522 | Striated Muscle Contraction | 0.140442 | 0.853 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.291431 | 0.535 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.062082 | 1.207 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.174703 | 0.758 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.180539 | 0.743 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.325484 | 0.487 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.336469 | 0.473 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.336469 | 0.473 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.336469 | 0.473 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.336469 | 0.473 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.336469 | 0.473 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.148975 | 0.827 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.368366 | 0.434 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.258221 | 0.588 |
R-HSA-72649 | Translation initiation complex formation | 0.270306 | 0.568 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.282386 | 0.549 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.294449 | 0.531 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.436975 | 0.360 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.446150 | 0.351 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.455176 | 0.342 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.455176 | 0.342 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.108443 | 0.965 |
R-HSA-9762292 | Regulation of CDH11 function | 0.192017 | 0.717 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.336376 | 0.473 |
R-HSA-6798695 | Neutrophil degranulation | 0.384294 | 0.415 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.036570 | 1.437 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.092564 | 1.034 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.092564 | 1.034 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.134885 | 0.870 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.368366 | 0.434 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.252181 | 0.598 |
R-HSA-9754189 | Germ layer formation at gastrulation | 0.325484 | 0.487 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.134885 | 0.870 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.163128 | 0.787 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.192297 | 0.716 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.126592 | 0.898 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.264264 | 0.578 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.058045 | 1.236 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.039432 | 1.404 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.428827 | 0.368 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.140442 | 0.853 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.192297 | 0.716 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.336469 | 0.473 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.222073 | 0.654 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.222073 | 0.654 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.222073 | 0.654 |
R-HSA-525793 | Myogenesis | 0.408530 | 0.389 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.455176 | 0.342 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.102739 | 0.988 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.229257 | 0.640 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.045307 | 1.344 |
R-HSA-5693538 | Homology Directed Repair | 0.067874 | 1.168 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.450906 | 0.346 |
R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.093700 | 1.028 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.151254 | 0.820 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.055397 | 1.257 |
R-HSA-193697 | p75NTR regulates axonogenesis | 0.178651 | 0.748 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.043034 | 1.366 |
R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.255666 | 0.592 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.105564 | 0.976 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.368366 | 0.434 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.388776 | 0.410 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.418167 | 0.379 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.436975 | 0.360 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.436975 | 0.360 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.256931 | 0.590 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.455176 | 0.342 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.455176 | 0.342 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.360014 | 0.444 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.073207 | 1.135 |
R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.230829 | 0.637 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.176539 | 0.753 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.117239 | 0.931 |
R-HSA-1234174 | Cellular response to hypoxia | 0.336376 | 0.473 |
R-HSA-9948299 | Ribosome-associated quality control | 0.467361 | 0.330 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.178651 | 0.748 |
R-HSA-6802949 | Signaling by RAS mutants | 0.222073 | 0.654 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.365877 | 0.437 |
R-HSA-9620244 | Long-term potentiation | 0.092564 | 1.034 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.216083 | 0.665 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.374964 | 0.426 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.039432 | 1.404 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.043233 | 1.364 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.368366 | 0.434 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.408530 | 0.389 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.464056 | 0.333 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.377540 | 0.423 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.424769 | 0.372 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.243349 | 0.614 |
R-HSA-73942 | DNA Damage Reversal | 0.267783 | 0.572 |
R-HSA-5689603 | UCH proteinases | 0.400590 | 0.397 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.389113 | 0.410 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.312486 | 0.505 |
R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.151254 | 0.820 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.165064 | 0.782 |
R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.165064 | 0.782 |
R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.165064 | 0.782 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.205166 | 0.688 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.082709 | 1.082 |
R-HSA-9018681 | Biosynthesis of protectins | 0.255666 | 0.592 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.314319 | 0.503 |
R-HSA-9834899 | Specification of the neural plate border | 0.325484 | 0.487 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.222073 | 0.654 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.152823 | 0.816 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.388776 | 0.410 |
R-HSA-1221632 | Meiotic synapsis | 0.264264 | 0.578 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.294449 | 0.531 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.300470 | 0.522 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.306483 | 0.514 |
R-HSA-6809371 | Formation of the cornified envelope | 0.192420 | 0.716 |
R-HSA-9615710 | Late endosomal microautophagy | 0.436975 | 0.360 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.464056 | 0.333 |
R-HSA-68875 | Mitotic Prophase | 0.376663 | 0.424 |
R-HSA-68877 | Mitotic Prometaphase | 0.062159 | 1.206 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.413115 | 0.384 |
R-HSA-9824272 | Somitogenesis | 0.216083 | 0.665 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.464056 | 0.333 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.398734 | 0.399 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.288420 | 0.540 |
R-HSA-195721 | Signaling by WNT | 0.268442 | 0.571 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.057540 | 1.240 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.151700 | 0.819 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.154237 | 0.812 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.122127 | 0.913 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.176539 | 0.753 |
R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.230829 | 0.637 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.134885 | 0.870 |
R-HSA-392517 | Rap1 signalling | 0.325484 | 0.487 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.192297 | 0.716 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.264264 | 0.578 |
R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.418167 | 0.379 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.418167 | 0.379 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.436975 | 0.360 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.354132 | 0.451 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.134885 | 0.870 |
R-HSA-8953854 | Metabolism of RNA | 0.044233 | 1.354 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.325484 | 0.487 |
R-HSA-182971 | EGFR downregulation | 0.455176 | 0.342 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.348231 | 0.458 |
R-HSA-2132295 | MHC class II antigen presentation | 0.189129 | 0.723 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.332265 | 0.479 |
R-HSA-389356 | Co-stimulation by CD28 | 0.234090 | 0.631 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.136852 | 0.864 |
R-HSA-444821 | Relaxin receptors | 0.122947 | 0.910 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.165064 | 0.782 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.073207 | 1.135 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.082709 | 1.082 |
R-HSA-428540 | Activation of RAC1 | 0.218102 | 0.661 |
R-HSA-1236977 | Endosomal/Vacuolar pathway | 0.218102 | 0.661 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.218102 | 0.661 |
R-HSA-9796292 | Formation of axial mesoderm | 0.243349 | 0.614 |
R-HSA-432047 | Passive transport by Aquaporins | 0.291431 | 0.535 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.258221 | 0.588 |
R-HSA-429947 | Deadenylation of mRNA | 0.388776 | 0.410 |
R-HSA-445355 | Smooth Muscle Contraction | 0.264264 | 0.578 |
R-HSA-1500620 | Meiosis | 0.197025 | 0.705 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.418167 | 0.379 |
R-HSA-5694530 | Cargo concentration in the ER | 0.455176 | 0.342 |
R-HSA-9659379 | Sensory processing of sound | 0.417614 | 0.379 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.144353 | 0.841 |
R-HSA-6787450 | tRNA modification in the mitochondrion | 0.291431 | 0.535 |
R-HSA-446728 | Cell junction organization | 0.219784 | 0.658 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.221134 | 0.655 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.283354 | 0.548 |
R-HSA-73894 | DNA Repair | 0.050716 | 1.295 |
R-HSA-199991 | Membrane Trafficking | 0.305364 | 0.515 |
R-HSA-69481 | G2/M Checkpoints | 0.205759 | 0.687 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.098308 | 1.007 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.098308 | 1.007 |
R-HSA-418990 | Adherens junctions interactions | 0.198476 | 0.702 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.122947 | 0.910 |
R-HSA-8964011 | HDL clearance | 0.137216 | 0.863 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.039432 | 1.404 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.178651 | 0.748 |
R-HSA-389513 | Co-inhibition by CTLA4 | 0.064091 | 1.193 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.243349 | 0.614 |
R-HSA-9678110 | Attachment and Entry | 0.279704 | 0.553 |
R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 0.302969 | 0.519 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.152823 | 0.816 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.168521 | 0.773 |
R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.446150 | 0.351 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.383338 | 0.416 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.440811 | 0.356 |
R-HSA-421270 | Cell-cell junction organization | 0.286537 | 0.543 |
R-HSA-1500931 | Cell-Cell communication | 0.104127 | 0.982 |
R-HSA-8852135 | Protein ubiquitination | 0.156703 | 0.805 |
R-HSA-9694614 | Attachment and Entry | 0.357907 | 0.446 |
R-HSA-9018676 | Biosynthesis of D-series resolvins | 0.368366 | 0.434 |
R-HSA-72312 | rRNA processing | 0.397016 | 0.401 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.047639 | 1.322 |
R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.178651 | 0.748 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.073207 | 1.135 |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.230829 | 0.637 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.267783 | 0.572 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.314319 | 0.503 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.378654 | 0.422 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.297495 | 0.527 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.170296 | 0.769 |
R-HSA-114452 | Activation of BH3-only proteins | 0.118535 | 0.926 |
R-HSA-9823730 | Formation of definitive endoderm | 0.336469 | 0.473 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.145159 | 0.838 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.264264 | 0.578 |
R-HSA-9020956 | Interleukin-27 signaling | 0.192017 | 0.717 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.357907 | 0.446 |
R-HSA-9635465 | Suppression of apoptosis | 0.205166 | 0.688 |
R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.205166 | 0.688 |
R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 0.255666 | 0.592 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.267783 | 0.572 |
R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.325484 | 0.487 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.357907 | 0.446 |
R-HSA-193648 | NRAGE signals death through JNK | 0.282386 | 0.549 |
R-HSA-3295583 | TRP channels | 0.408530 | 0.389 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.418167 | 0.379 |
R-HSA-177929 | Signaling by EGFR | 0.282386 | 0.549 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.163500 | 0.786 |
R-HSA-112310 | Neurotransmitter release cycle | 0.222312 | 0.653 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.216083 | 0.665 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.395706 | 0.403 |
R-HSA-438064 | Post NMDA receptor activation events | 0.467146 | 0.331 |
R-HSA-194138 | Signaling by VEGF | 0.199055 | 0.701 |
R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.165064 | 0.782 |
R-HSA-9683686 | Maturation of spike protein | 0.192017 | 0.717 |
R-HSA-1482801 | Acyl chain remodelling of PS | 0.092564 | 1.034 |
R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.230829 | 0.637 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.267783 | 0.572 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 0.314319 | 0.503 |
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.325484 | 0.487 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.408530 | 0.389 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.418167 | 0.379 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.446150 | 0.351 |
R-HSA-6807070 | PTEN Regulation | 0.254322 | 0.595 |
R-HSA-4086400 | PCP/CE pathway | 0.411966 | 0.385 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.416013 | 0.381 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.137627 | 0.861 |
R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 0.436975 | 0.360 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.458949 | 0.338 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.334347 | 0.476 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.102204 | 0.991 |
R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 0.347276 | 0.459 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.141376 | 0.850 |
R-HSA-9031628 | NGF-stimulated transcription | 0.234090 | 0.631 |
R-HSA-9830364 | Formation of the nephric duct | 0.398734 | 0.399 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.377540 | 0.423 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.377540 | 0.423 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.389113 | 0.410 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.178651 | 0.748 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.243349 | 0.614 |
R-HSA-9629569 | Protein hydroxylation | 0.336469 | 0.473 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.270105 | 0.568 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.365877 | 0.437 |
R-HSA-376176 | Signaling by ROBO receptors | 0.300659 | 0.522 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.418167 | 0.379 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.335768 | 0.474 |
R-HSA-180292 | GAB1 signalosome | 0.314319 | 0.503 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.318478 | 0.497 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.450906 | 0.346 |
R-HSA-1474165 | Reproduction | 0.429084 | 0.367 |
R-HSA-6807004 | Negative regulation of MET activity | 0.336469 | 0.473 |
R-HSA-180024 | DARPP-32 events | 0.436975 | 0.360 |
R-HSA-210745 | Regulation of gene expression in beta cells | 0.436975 | 0.360 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.377540 | 0.423 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.177833 | 0.750 |
R-HSA-373753 | Nephrin family interactions | 0.064091 | 1.193 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 0.068598 | 1.164 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.097614 | 1.010 |
R-HSA-8984722 | Interleukin-35 Signalling | 0.230829 | 0.637 |
R-HSA-435354 | Zinc transporters | 0.255666 | 0.592 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.300470 | 0.522 |
R-HSA-162906 | HIV Infection | 0.380890 | 0.419 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.325484 | 0.487 |
R-HSA-425410 | Metal ion SLC transporters | 0.234090 | 0.631 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.368366 | 0.434 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.446150 | 0.351 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.134885 | 0.870 |
R-HSA-3000170 | Syndecan interactions | 0.378654 | 0.422 |
R-HSA-2024096 | HS-GAG degradation | 0.464056 | 0.333 |
R-HSA-162587 | HIV Life Cycle | 0.323291 | 0.490 |
R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.108443 | 0.965 |
R-HSA-449836 | Other interleukin signaling | 0.325484 | 0.487 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.383338 | 0.416 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.291431 | 0.535 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.095618 | 1.019 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.059689 | 1.224 |
R-HSA-75153 | Apoptotic execution phase | 0.060155 | 1.221 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.155536 | 0.808 |
R-HSA-109581 | Apoptosis | 0.077935 | 1.108 |
R-HSA-75205 | Dissolution of Fibrin Clot | 0.205166 | 0.688 |
R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.243349 | 0.614 |
R-HSA-168268 | Virus Assembly and Release | 0.279704 | 0.553 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.168898 | 0.772 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.133448 | 0.875 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.282386 | 0.549 |
R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.302969 | 0.519 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.101955 | 0.992 |
R-HSA-9694635 | Translation of Structural Proteins | 0.406291 | 0.391 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.072495 | 1.140 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.133448 | 0.875 |
R-HSA-5620971 | Pyroptosis | 0.427648 | 0.369 |
R-HSA-5357801 | Programmed Cell Death | 0.079398 | 1.100 |
R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.255666 | 0.592 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.086084 | 1.065 |
R-HSA-9020591 | Interleukin-12 signaling | 0.050714 | 1.295 |
R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.325484 | 0.487 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.314319 | 0.503 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.368366 | 0.434 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.254322 | 0.595 |
R-HSA-9679506 | SARS-CoV Infections | 0.471828 | 0.326 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.472792 | 0.325 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.472792 | 0.325 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.472792 | 0.325 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.472792 | 0.325 |
R-HSA-9930044 | Nuclear RNA decay | 0.472792 | 0.325 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.472792 | 0.325 |
R-HSA-9733709 | Cardiogenesis | 0.472792 | 0.325 |
R-HSA-354192 | Integrin signaling | 0.472792 | 0.325 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.481385 | 0.318 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.481385 | 0.318 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.481385 | 0.318 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 0.481385 | 0.318 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.488350 | 0.311 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.489840 | 0.310 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.489840 | 0.310 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.489840 | 0.310 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.489840 | 0.310 |
R-HSA-203615 | eNOS activation | 0.489840 | 0.310 |
R-HSA-180746 | Nuclear import of Rev protein | 0.489840 | 0.310 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.489840 | 0.310 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.489840 | 0.310 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.489840 | 0.310 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.489840 | 0.310 |
R-HSA-597592 | Post-translational protein modification | 0.492784 | 0.307 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.498156 | 0.303 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.498156 | 0.303 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.498156 | 0.303 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.498156 | 0.303 |
R-HSA-169911 | Regulation of Apoptosis | 0.498156 | 0.303 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.498753 | 0.302 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.506338 | 0.296 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.506338 | 0.296 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.506338 | 0.296 |
R-HSA-6805567 | Keratinization | 0.507960 | 0.294 |
R-HSA-1474290 | Collagen formation | 0.509021 | 0.293 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.514103 | 0.289 |
R-HSA-1296072 | Voltage gated Potassium channels | 0.514387 | 0.289 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.514387 | 0.289 |
R-HSA-4641258 | Degradation of DVL | 0.514387 | 0.289 |
R-HSA-4641257 | Degradation of AXIN | 0.514387 | 0.289 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.514387 | 0.289 |
R-HSA-196757 | Metabolism of folate and pterines | 0.514387 | 0.289 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.519151 | 0.285 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.520530 | 0.284 |
R-HSA-6785470 | tRNA processing in the mitochondrion | 0.522305 | 0.282 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.522305 | 0.282 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.522305 | 0.282 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.522305 | 0.282 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.524501 | 0.280 |
R-HSA-397014 | Muscle contraction | 0.528426 | 0.277 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.528455 | 0.277 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.529141 | 0.276 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.530095 | 0.276 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.530095 | 0.276 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.530095 | 0.276 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.530095 | 0.276 |
R-HSA-69541 | Stabilization of p53 | 0.530095 | 0.276 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.530095 | 0.276 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.530095 | 0.276 |
R-HSA-73887 | Death Receptor Signaling | 0.536308 | 0.271 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.537758 | 0.269 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.537758 | 0.269 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.537758 | 0.269 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.537758 | 0.269 |
R-HSA-8868766 | rRNA processing in the mitochondrion | 0.537758 | 0.269 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.537758 | 0.269 |
R-HSA-9614085 | FOXO-mediated transcription | 0.538989 | 0.268 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.545296 | 0.263 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.545296 | 0.263 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.545296 | 0.263 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.545296 | 0.263 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.545296 | 0.263 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.545296 | 0.263 |
R-HSA-9694548 | Maturation of spike protein | 0.545296 | 0.263 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.545296 | 0.263 |
R-HSA-9607240 | FLT3 Signaling | 0.545296 | 0.263 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.545518 | 0.263 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.552712 | 0.258 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.552712 | 0.258 |
R-HSA-6811438 | Intra-Golgi traffic | 0.552712 | 0.258 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.552712 | 0.258 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.552712 | 0.258 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.552712 | 0.258 |
R-HSA-9683701 | Translation of Structural Proteins | 0.552712 | 0.258 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.553495 | 0.257 |
R-HSA-1483255 | PI Metabolism | 0.553495 | 0.257 |
R-HSA-8951664 | Neddylation | 0.558330 | 0.253 |
R-HSA-5683057 | MAPK family signaling cascades | 0.558890 | 0.253 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.560008 | 0.252 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.560008 | 0.252 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.560008 | 0.252 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.560008 | 0.252 |
R-HSA-165159 | MTOR signalling | 0.560008 | 0.252 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.567185 | 0.246 |
R-HSA-8854214 | TBC/RABGAPs | 0.567185 | 0.246 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 0.567185 | 0.246 |
R-HSA-9907900 | Proteasome assembly | 0.574245 | 0.241 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.574245 | 0.241 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.574245 | 0.241 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.574245 | 0.241 |
R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.574245 | 0.241 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.574245 | 0.241 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.576949 | 0.239 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.580873 | 0.236 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.581191 | 0.236 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.581191 | 0.236 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.581191 | 0.236 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.581191 | 0.236 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.581191 | 0.236 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.581191 | 0.236 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.581191 | 0.236 |
R-HSA-211000 | Gene Silencing by RNA | 0.581530 | 0.235 |
R-HSA-5619102 | SLC transporter disorders | 0.585480 | 0.232 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.586076 | 0.232 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.586076 | 0.232 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.586076 | 0.232 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.588023 | 0.231 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.588023 | 0.231 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.588023 | 0.231 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.588023 | 0.231 |
R-HSA-9675135 | Diseases of DNA repair | 0.588023 | 0.231 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.588023 | 0.231 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.594745 | 0.226 |
R-HSA-202403 | TCR signaling | 0.595057 | 0.225 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.603892 | 0.219 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.603892 | 0.219 |
R-HSA-5653656 | Vesicle-mediated transport | 0.604550 | 0.219 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.607862 | 0.216 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.607862 | 0.216 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.607862 | 0.216 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.607862 | 0.216 |
R-HSA-5689880 | Ub-specific processing proteases | 0.610547 | 0.214 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.614261 | 0.212 |
R-HSA-449147 | Signaling by Interleukins | 0.617286 | 0.210 |
R-HSA-157118 | Signaling by NOTCH | 0.617946 | 0.209 |
R-HSA-912446 | Meiotic recombination | 0.620556 | 0.207 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.620556 | 0.207 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.620556 | 0.207 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.626749 | 0.203 |
R-HSA-68949 | Orc1 removal from chromatin | 0.626749 | 0.203 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.626749 | 0.203 |
R-HSA-6794361 | Neurexins and neuroligins | 0.626749 | 0.203 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.629523 | 0.201 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.629523 | 0.201 |
R-HSA-373760 | L1CAM interactions | 0.629523 | 0.201 |
R-HSA-168255 | Influenza Infection | 0.631216 | 0.200 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.632841 | 0.199 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.632841 | 0.199 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.632841 | 0.199 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.632841 | 0.199 |
R-HSA-9007101 | Rab regulation of trafficking | 0.633667 | 0.198 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.637776 | 0.195 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.638607 | 0.195 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.638834 | 0.195 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.638834 | 0.195 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.641848 | 0.193 |
R-HSA-4839726 | Chromatin organization | 0.644376 | 0.191 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.644730 | 0.191 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.644730 | 0.191 |
R-HSA-3371556 | Cellular response to heat stress | 0.649884 | 0.187 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.650529 | 0.187 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.650529 | 0.187 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.656235 | 0.183 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.657777 | 0.182 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.657777 | 0.182 |
R-HSA-5688426 | Deubiquitination | 0.661319 | 0.180 |
R-HSA-162909 | Host Interactions of HIV factors | 0.661671 | 0.179 |
R-HSA-6782135 | Dual incision in TC-NER | 0.661847 | 0.179 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.664001 | 0.178 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.664089 | 0.178 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.667369 | 0.176 |
R-HSA-191859 | snRNP Assembly | 0.667369 | 0.176 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.667369 | 0.176 |
R-HSA-186712 | Regulation of beta-cell development | 0.667369 | 0.176 |
R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.667369 | 0.176 |
R-HSA-69206 | G1/S Transition | 0.669350 | 0.174 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.672800 | 0.172 |
R-HSA-379724 | tRNA Aminoacylation | 0.672800 | 0.172 |
R-HSA-983189 | Kinesins | 0.672800 | 0.172 |
R-HSA-351202 | Metabolism of polyamines | 0.672800 | 0.172 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.672800 | 0.172 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.672800 | 0.172 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.672800 | 0.172 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.672800 | 0.172 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.672800 | 0.172 |
R-HSA-1227986 | Signaling by ERBB2 | 0.672800 | 0.172 |
R-HSA-114608 | Platelet degranulation | 0.676889 | 0.169 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.678143 | 0.169 |
R-HSA-445717 | Aquaporin-mediated transport | 0.678143 | 0.169 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.678143 | 0.169 |
R-HSA-1442490 | Collagen degradation | 0.678143 | 0.169 |
R-HSA-1280218 | Adaptive Immune System | 0.679162 | 0.168 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.680606 | 0.167 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.683399 | 0.165 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.683399 | 0.165 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.683399 | 0.165 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.683399 | 0.165 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.688570 | 0.162 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.688570 | 0.162 |
R-HSA-373755 | Semaphorin interactions | 0.688570 | 0.162 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.688570 | 0.162 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.688570 | 0.162 |
R-HSA-8848021 | Signaling by PTK6 | 0.688570 | 0.162 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.692382 | 0.160 |
R-HSA-112316 | Neuronal System | 0.692471 | 0.160 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.697483 | 0.156 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.698669 | 0.156 |
R-HSA-428157 | Sphingolipid metabolism | 0.700402 | 0.155 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.702179 | 0.154 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.703582 | 0.153 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.703582 | 0.153 |
R-HSA-9830369 | Kidney development | 0.708425 | 0.150 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.708425 | 0.150 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.711312 | 0.148 |
R-HSA-422475 | Axon guidance | 0.712260 | 0.147 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.713188 | 0.147 |
R-HSA-5218859 | Regulated Necrosis | 0.713188 | 0.147 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.714747 | 0.146 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.719223 | 0.143 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.722484 | 0.141 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.722484 | 0.141 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.727018 | 0.138 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.727018 | 0.138 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.727018 | 0.138 |
R-HSA-3000178 | ECM proteoglycans | 0.727018 | 0.138 |
R-HSA-8978934 | Metabolism of cofactors | 0.727018 | 0.138 |
R-HSA-5632684 | Hedgehog 'on' state | 0.727018 | 0.138 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.731479 | 0.136 |
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.731479 | 0.136 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.733779 | 0.134 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.735310 | 0.134 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.735867 | 0.133 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.735867 | 0.133 |
R-HSA-4086398 | Ca2+ pathway | 0.735867 | 0.133 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.738588 | 0.132 |
R-HSA-380287 | Centrosome maturation | 0.744430 | 0.128 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.744430 | 0.128 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.744430 | 0.128 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.744430 | 0.128 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.748607 | 0.126 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.750858 | 0.124 |
R-HSA-216083 | Integrin cell surface interactions | 0.756759 | 0.121 |
R-HSA-5619084 | ABC transporter disorders | 0.756759 | 0.121 |
R-HSA-69242 | S Phase | 0.756806 | 0.121 |
R-HSA-166520 | Signaling by NTRKs | 0.756806 | 0.121 |
R-HSA-9758941 | Gastrulation | 0.759734 | 0.119 |
R-HSA-1483257 | Phospholipid metabolism | 0.760081 | 0.119 |
R-HSA-5654738 | Signaling by FGFR2 | 0.764647 | 0.117 |
R-HSA-6806834 | Signaling by MET | 0.764647 | 0.117 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.768335 | 0.114 |
R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.768495 | 0.114 |
R-HSA-977225 | Amyloid fiber formation | 0.768495 | 0.114 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.768950 | 0.114 |
R-HSA-9675108 | Nervous system development | 0.774447 | 0.111 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.776004 | 0.110 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.776668 | 0.110 |
R-HSA-74160 | Gene expression (Transcription) | 0.776950 | 0.110 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.779667 | 0.108 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.779667 | 0.108 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.779667 | 0.108 |
R-HSA-9610379 | HCMV Late Events | 0.782078 | 0.107 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.783270 | 0.106 |
R-HSA-9711097 | Cellular response to starvation | 0.784739 | 0.105 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.786815 | 0.104 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.786815 | 0.104 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.787296 | 0.104 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.790302 | 0.102 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.790302 | 0.102 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.790302 | 0.102 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.793732 | 0.100 |
R-HSA-70268 | Pyruvate metabolism | 0.793732 | 0.100 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.797106 | 0.098 |
R-HSA-156902 | Peptide chain elongation | 0.797106 | 0.098 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.800117 | 0.097 |
R-HSA-1236974 | ER-Phagosome pathway | 0.800425 | 0.097 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.803690 | 0.095 |
R-HSA-202424 | Downstream TCR signaling | 0.803690 | 0.095 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.806902 | 0.093 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.810062 | 0.091 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.813170 | 0.090 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.813170 | 0.090 |
R-HSA-391251 | Protein folding | 0.813170 | 0.090 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.813170 | 0.090 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.816227 | 0.088 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.816790 | 0.088 |
R-HSA-72306 | tRNA processing | 0.816824 | 0.088 |
R-HSA-418555 | G alpha (s) signalling events | 0.819106 | 0.087 |
R-HSA-392499 | Metabolism of proteins | 0.819921 | 0.086 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.821363 | 0.085 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.825103 | 0.083 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.825103 | 0.083 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.827966 | 0.082 |
R-HSA-1296071 | Potassium Channels | 0.827966 | 0.082 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.827966 | 0.082 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.827984 | 0.082 |
R-HSA-190236 | Signaling by FGFR | 0.833552 | 0.079 |
R-HSA-3214847 | HATs acetylate histones | 0.836277 | 0.078 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.836277 | 0.078 |
R-HSA-5610787 | Hedgehog 'off' state | 0.838957 | 0.076 |
R-HSA-70171 | Glycolysis | 0.838957 | 0.076 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.838957 | 0.076 |
R-HSA-2408557 | Selenocysteine synthesis | 0.841594 | 0.075 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.841594 | 0.075 |
R-HSA-9020702 | Interleukin-1 signaling | 0.841594 | 0.075 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.844188 | 0.074 |
R-HSA-162582 | Signal Transduction | 0.846152 | 0.073 |
R-HSA-192823 | Viral mRNA Translation | 0.846739 | 0.072 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.849249 | 0.071 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.849249 | 0.071 |
R-HSA-111885 | Opioid Signalling | 0.849249 | 0.071 |
R-HSA-9824446 | Viral Infection Pathways | 0.850344 | 0.070 |
R-HSA-69275 | G2/M Transition | 0.850414 | 0.070 |
R-HSA-9833110 | RSV-host interactions | 0.851718 | 0.070 |
R-HSA-9711123 | Cellular response to chemical stress | 0.852284 | 0.069 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.854147 | 0.068 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.854195 | 0.068 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.858886 | 0.066 |
R-HSA-69239 | Synthesis of DNA | 0.858886 | 0.066 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.861197 | 0.065 |
R-HSA-2672351 | Stimuli-sensing channels | 0.861197 | 0.065 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.861498 | 0.065 |
R-HSA-72766 | Translation | 0.862420 | 0.064 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.863471 | 0.064 |
R-HSA-8953897 | Cellular responses to stimuli | 0.865584 | 0.063 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.865708 | 0.063 |
R-HSA-6803157 | Antimicrobial peptides | 0.867908 | 0.062 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.875112 | 0.058 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.879892 | 0.056 |
R-HSA-70326 | Glucose metabolism | 0.884266 | 0.053 |
R-HSA-2980736 | Peptide hormone metabolism | 0.884266 | 0.053 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.891671 | 0.050 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.891671 | 0.050 |
R-HSA-212436 | Generic Transcription Pathway | 0.907757 | 0.042 |
R-HSA-9909396 | Circadian clock | 0.912630 | 0.040 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.912630 | 0.040 |
R-HSA-5358351 | Signaling by Hedgehog | 0.922187 | 0.035 |
R-HSA-2262752 | Cellular responses to stress | 0.923436 | 0.035 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.924721 | 0.034 |
R-HSA-9664407 | Parasite infection | 0.924721 | 0.034 |
R-HSA-9664417 | Leishmania phagocytosis | 0.924721 | 0.034 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.925958 | 0.033 |
R-HSA-1632852 | Macroautophagy | 0.925958 | 0.033 |
R-HSA-1474244 | Extracellular matrix organization | 0.928285 | 0.032 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.928369 | 0.032 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.929546 | 0.032 |
R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.929546 | 0.032 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.930703 | 0.031 |
R-HSA-9609646 | HCMV Infection | 0.936640 | 0.028 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.937259 | 0.028 |
R-HSA-2142753 | Arachidonate metabolism | 0.939304 | 0.027 |
R-HSA-446652 | Interleukin-1 family signaling | 0.939304 | 0.027 |
R-HSA-69306 | DNA Replication | 0.940301 | 0.027 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.941282 | 0.026 |
R-HSA-9612973 | Autophagy | 0.943197 | 0.025 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.945049 | 0.025 |
R-HSA-9734767 | Developmental Cell Lineages | 0.946947 | 0.024 |
R-HSA-388396 | GPCR downstream signalling | 0.951035 | 0.022 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.956434 | 0.019 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.958549 | 0.018 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.965553 | 0.015 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.966036 | 0.015 |
R-HSA-983712 | Ion channel transport | 0.967686 | 0.014 |
R-HSA-5617833 | Cilium Assembly | 0.968219 | 0.014 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.968742 | 0.014 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.969764 | 0.013 |
R-HSA-9609690 | HCMV Early Events | 0.971234 | 0.013 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.972989 | 0.012 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.974393 | 0.011 |
R-HSA-5663205 | Infectious disease | 0.976970 | 0.010 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.977066 | 0.010 |
R-HSA-372790 | Signaling by GPCR | 0.977428 | 0.010 |
R-HSA-168249 | Innate Immune System | 0.978341 | 0.010 |
R-HSA-109582 | Hemostasis | 0.979365 | 0.009 |
R-HSA-168256 | Immune System | 0.980272 | 0.009 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.983929 | 0.007 |
R-HSA-382551 | Transport of small molecules | 0.985088 | 0.007 |
R-HSA-15869 | Metabolism of nucleotides | 0.985458 | 0.006 |
R-HSA-8939211 | ESR-mediated signaling | 0.985698 | 0.006 |
R-HSA-1643685 | Disease | 0.986622 | 0.006 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.987268 | 0.006 |
R-HSA-1266738 | Developmental Biology | 0.989925 | 0.004 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.993136 | 0.003 |
R-HSA-9658195 | Leishmania infection | 0.993136 | 0.003 |
R-HSA-418594 | G alpha (i) signalling events | 0.993306 | 0.003 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.996425 | 0.002 |
R-HSA-8957322 | Metabolism of steroids | 0.996657 | 0.001 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.996719 | 0.001 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997486 | 0.001 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.998262 | 0.001 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998378 | 0.001 |
R-HSA-913531 | Interferon Signaling | 0.998779 | 0.001 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998985 | 0.000 |
R-HSA-8978868 | Fatty acid metabolism | 0.999185 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 0.999963 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999986 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CK2A2 |
0.810 | 0.537 | 1 | 0.801 |
FAM20C |
0.806 | 0.277 | 2 | 0.787 |
COT |
0.800 | 0.157 | 2 | 0.838 |
CK2A1 |
0.796 | 0.483 | 1 | 0.778 |
GRK1 |
0.793 | 0.242 | -2 | 0.786 |
GRK7 |
0.789 | 0.350 | 1 | 0.790 |
GRK6 |
0.789 | 0.334 | 1 | 0.870 |
CLK3 |
0.789 | 0.088 | 1 | 0.810 |
BMPR1B |
0.786 | 0.234 | 1 | 0.855 |
IKKA |
0.786 | 0.204 | -2 | 0.712 |
CAMK2G |
0.785 | 0.189 | 2 | 0.805 |
MOS |
0.785 | 0.126 | 1 | 0.913 |
CDC7 |
0.785 | 0.052 | 1 | 0.909 |
DSTYK |
0.783 | 0.100 | 2 | 0.849 |
TGFBR1 |
0.783 | 0.252 | -2 | 0.873 |
CAMK2B |
0.783 | 0.212 | 2 | 0.820 |
IKKB |
0.782 | 0.126 | -2 | 0.714 |
ALK2 |
0.780 | 0.284 | -2 | 0.877 |
BMPR1A |
0.778 | 0.236 | 1 | 0.850 |
PIM3 |
0.777 | 0.057 | -3 | 0.821 |
PRPK |
0.776 | 0.006 | -1 | 0.838 |
ATM |
0.776 | 0.112 | 1 | 0.784 |
RAF1 |
0.774 | -0.043 | 1 | 0.854 |
PLK3 |
0.774 | 0.237 | 2 | 0.744 |
NDR2 |
0.773 | 0.012 | -3 | 0.819 |
GRK4 |
0.772 | 0.119 | -2 | 0.828 |
GRK5 |
0.770 | 0.108 | -3 | 0.841 |
TBK1 |
0.770 | -0.027 | 1 | 0.746 |
BMPR2 |
0.770 | 0.007 | -2 | 0.881 |
ACVR2B |
0.770 | 0.179 | -2 | 0.860 |
ACVR2A |
0.770 | 0.183 | -2 | 0.856 |
ALK4 |
0.769 | 0.178 | -2 | 0.891 |
CAMK2A |
0.769 | 0.130 | 2 | 0.805 |
MTOR |
0.769 | -0.050 | 1 | 0.779 |
CAMK1B |
0.768 | -0.007 | -3 | 0.848 |
GCN2 |
0.768 | -0.100 | 2 | 0.714 |
IKKE |
0.768 | -0.022 | 1 | 0.739 |
ATR |
0.768 | 0.022 | 1 | 0.835 |
MAPKAPK2 |
0.767 | 0.116 | -3 | 0.720 |
PLK1 |
0.767 | 0.157 | -2 | 0.837 |
PDHK4 |
0.766 | -0.111 | 1 | 0.854 |
RSK2 |
0.766 | 0.046 | -3 | 0.763 |
HUNK |
0.765 | -0.021 | 2 | 0.737 |
PIM1 |
0.765 | 0.057 | -3 | 0.770 |
SKMLCK |
0.764 | 0.010 | -2 | 0.818 |
PKN3 |
0.764 | -0.013 | -3 | 0.820 |
TGFBR2 |
0.763 | -0.020 | -2 | 0.870 |
MARK4 |
0.762 | -0.041 | 4 | 0.684 |
CDKL1 |
0.762 | -0.016 | -3 | 0.797 |
LATS2 |
0.762 | 0.033 | -5 | 0.727 |
PLK2 |
0.762 | 0.213 | -3 | 0.882 |
LATS1 |
0.762 | 0.093 | -3 | 0.833 |
NEK6 |
0.762 | -0.065 | -2 | 0.864 |
NEK7 |
0.761 | -0.087 | -3 | 0.817 |
CAMK2D |
0.761 | 0.034 | -3 | 0.813 |
KIS |
0.760 | -0.002 | 1 | 0.650 |
ULK2 |
0.760 | -0.126 | 2 | 0.698 |
PRKD1 |
0.760 | -0.019 | -3 | 0.798 |
CAMLCK |
0.759 | -0.033 | -2 | 0.819 |
PDHK1 |
0.758 | -0.118 | 1 | 0.847 |
CLK2 |
0.757 | 0.059 | -3 | 0.742 |
ERK5 |
0.757 | -0.042 | 1 | 0.767 |
MLK1 |
0.756 | -0.083 | 2 | 0.736 |
RSK4 |
0.756 | 0.061 | -3 | 0.736 |
SRPK1 |
0.756 | -0.022 | -3 | 0.741 |
P90RSK |
0.756 | -0.004 | -3 | 0.767 |
DAPK2 |
0.755 | -0.060 | -3 | 0.848 |
NLK |
0.755 | -0.113 | 1 | 0.795 |
NUAK2 |
0.755 | -0.073 | -3 | 0.825 |
RIPK3 |
0.755 | -0.175 | 3 | 0.212 |
TSSK2 |
0.755 | -0.020 | -5 | 0.811 |
NDR1 |
0.755 | -0.067 | -3 | 0.814 |
NIK |
0.755 | -0.122 | -3 | 0.860 |
MST4 |
0.755 | -0.083 | 2 | 0.784 |
BCKDK |
0.755 | -0.056 | -1 | 0.779 |
DNAPK |
0.754 | 0.078 | 1 | 0.698 |
DLK |
0.754 | -0.048 | 1 | 0.850 |
ULK1 |
0.753 | -0.095 | -3 | 0.816 |
AMPKA1 |
0.753 | -0.062 | -3 | 0.828 |
MSK2 |
0.752 | 0.009 | -3 | 0.730 |
WNK1 |
0.752 | -0.115 | -2 | 0.819 |
P70S6KB |
0.752 | -0.024 | -3 | 0.785 |
PRKD2 |
0.752 | -0.025 | -3 | 0.754 |
CHAK2 |
0.751 | -0.102 | -1 | 0.835 |
MSK1 |
0.751 | 0.034 | -3 | 0.737 |
GRK2 |
0.751 | 0.046 | -2 | 0.723 |
RSK3 |
0.750 | -0.035 | -3 | 0.767 |
SRPK2 |
0.750 | -0.016 | -3 | 0.676 |
TSSK1 |
0.750 | -0.053 | -3 | 0.846 |
MAPKAPK3 |
0.750 | -0.000 | -3 | 0.754 |
PKCD |
0.749 | -0.057 | 2 | 0.714 |
ICK |
0.749 | -0.037 | -3 | 0.822 |
CDKL5 |
0.749 | -0.045 | -3 | 0.785 |
TLK2 |
0.749 | 0.054 | 1 | 0.782 |
WNK3 |
0.749 | -0.188 | 1 | 0.807 |
PKACG |
0.749 | -0.022 | -2 | 0.715 |
TTBK2 |
0.748 | -0.037 | 2 | 0.614 |
MARK2 |
0.748 | -0.031 | 4 | 0.616 |
PRKX |
0.748 | 0.058 | -3 | 0.665 |
SRPK3 |
0.748 | -0.031 | -3 | 0.724 |
MASTL |
0.747 | -0.191 | -2 | 0.781 |
NIM1 |
0.747 | -0.101 | 3 | 0.268 |
ANKRD3 |
0.746 | -0.170 | 1 | 0.850 |
GRK3 |
0.746 | 0.080 | -2 | 0.690 |
JNK3 |
0.746 | 0.032 | 1 | 0.607 |
MEK1 |
0.746 | -0.064 | 2 | 0.769 |
BRAF |
0.746 | 0.016 | -4 | 0.742 |
PKN2 |
0.745 | -0.113 | -3 | 0.812 |
HIPK4 |
0.745 | -0.077 | 1 | 0.732 |
CDK8 |
0.745 | -0.030 | 1 | 0.627 |
QSK |
0.745 | -0.067 | 4 | 0.654 |
PKACB |
0.745 | 0.026 | -2 | 0.652 |
MARK3 |
0.745 | -0.043 | 4 | 0.629 |
PASK |
0.745 | 0.054 | -3 | 0.833 |
AMPKA2 |
0.744 | -0.075 | -3 | 0.799 |
AURA |
0.744 | 0.010 | -2 | 0.619 |
PAK1 |
0.744 | -0.015 | -2 | 0.740 |
MLK4 |
0.743 | -0.045 | 2 | 0.643 |
CLK4 |
0.743 | -0.007 | -3 | 0.757 |
NEK9 |
0.743 | -0.178 | 2 | 0.745 |
GSK3A |
0.743 | 0.029 | 4 | 0.361 |
JNK2 |
0.742 | 0.024 | 1 | 0.571 |
PKR |
0.742 | -0.094 | 1 | 0.823 |
MLK3 |
0.742 | -0.084 | 2 | 0.664 |
CDK1 |
0.742 | -0.029 | 1 | 0.584 |
DRAK1 |
0.742 | -0.024 | 1 | 0.781 |
RIPK1 |
0.741 | -0.208 | 1 | 0.797 |
CHK1 |
0.741 | -0.017 | -3 | 0.824 |
CAMK4 |
0.741 | -0.082 | -3 | 0.800 |
AURC |
0.740 | -0.032 | -2 | 0.641 |
NUAK1 |
0.740 | -0.090 | -3 | 0.782 |
MARK1 |
0.740 | -0.058 | 4 | 0.646 |
MYLK4 |
0.740 | -0.035 | -2 | 0.732 |
YSK4 |
0.739 | -0.101 | 1 | 0.787 |
SIK |
0.739 | -0.071 | -3 | 0.752 |
DYRK2 |
0.739 | -0.030 | 1 | 0.640 |
BRSK1 |
0.739 | -0.059 | -3 | 0.776 |
SMG1 |
0.737 | -0.040 | 1 | 0.783 |
MEKK3 |
0.737 | -0.062 | 1 | 0.808 |
VRK2 |
0.736 | -0.258 | 1 | 0.864 |
CLK1 |
0.736 | -0.025 | -3 | 0.735 |
IRE2 |
0.736 | -0.159 | 2 | 0.668 |
TLK1 |
0.736 | -0.030 | -2 | 0.857 |
MLK2 |
0.736 | -0.215 | 2 | 0.731 |
CDK19 |
0.735 | -0.042 | 1 | 0.585 |
CK1E |
0.734 | -0.020 | -3 | 0.531 |
CDK5 |
0.734 | -0.068 | 1 | 0.645 |
PLK4 |
0.734 | -0.072 | 2 | 0.543 |
QIK |
0.734 | -0.156 | -3 | 0.807 |
PRKD3 |
0.734 | -0.062 | -3 | 0.733 |
AURB |
0.734 | -0.039 | -2 | 0.638 |
PAK3 |
0.734 | -0.091 | -2 | 0.734 |
PAK2 |
0.733 | -0.056 | -2 | 0.727 |
CDK3 |
0.733 | -0.031 | 1 | 0.522 |
CDK2 |
0.733 | -0.083 | 1 | 0.673 |
PKCG |
0.733 | -0.095 | 2 | 0.654 |
PKCB |
0.733 | -0.094 | 2 | 0.660 |
IRE1 |
0.733 | -0.208 | 1 | 0.765 |
MNK2 |
0.732 | -0.093 | -2 | 0.751 |
SGK3 |
0.732 | -0.017 | -3 | 0.741 |
P38A |
0.732 | -0.038 | 1 | 0.649 |
P38B |
0.732 | -0.011 | 1 | 0.581 |
JNK1 |
0.732 | 0.019 | 1 | 0.562 |
GSK3B |
0.731 | -0.039 | 4 | 0.345 |
PKCA |
0.731 | -0.096 | 2 | 0.645 |
GAK |
0.731 | 0.036 | 1 | 0.845 |
PIM2 |
0.730 | -0.027 | -3 | 0.738 |
PERK |
0.730 | -0.116 | -2 | 0.864 |
MELK |
0.730 | -0.132 | -3 | 0.781 |
PAK6 |
0.730 | -0.028 | -2 | 0.666 |
MEKK1 |
0.730 | -0.157 | 1 | 0.817 |
P38G |
0.729 | -0.011 | 1 | 0.494 |
MAPKAPK5 |
0.729 | -0.077 | -3 | 0.709 |
DYRK4 |
0.729 | -0.002 | 1 | 0.570 |
DCAMKL1 |
0.729 | -0.050 | -3 | 0.769 |
NEK2 |
0.729 | -0.132 | 2 | 0.704 |
PKACA |
0.729 | 0.011 | -2 | 0.606 |
TAO3 |
0.728 | -0.077 | 1 | 0.798 |
MEKK2 |
0.728 | -0.117 | 2 | 0.719 |
PKCH |
0.728 | -0.110 | 2 | 0.636 |
CDK13 |
0.728 | -0.070 | 1 | 0.599 |
CAMK1G |
0.728 | -0.072 | -3 | 0.753 |
CDK7 |
0.728 | -0.087 | 1 | 0.631 |
ERK1 |
0.728 | -0.032 | 1 | 0.568 |
MNK1 |
0.728 | -0.092 | -2 | 0.763 |
PKG2 |
0.727 | -0.048 | -2 | 0.654 |
AKT2 |
0.727 | -0.036 | -3 | 0.684 |
ZAK |
0.727 | -0.138 | 1 | 0.805 |
HRI |
0.727 | -0.182 | -2 | 0.862 |
CAMK1D |
0.726 | -0.002 | -3 | 0.670 |
CHAK1 |
0.726 | -0.207 | 2 | 0.640 |
BRSK2 |
0.726 | -0.142 | -3 | 0.787 |
SSTK |
0.725 | -0.088 | 4 | 0.644 |
ERK2 |
0.725 | -0.053 | 1 | 0.611 |
PRP4 |
0.725 | -0.053 | -3 | 0.716 |
PINK1 |
0.725 | -0.129 | 1 | 0.783 |
DAPK3 |
0.725 | -0.015 | -3 | 0.782 |
SMMLCK |
0.725 | -0.070 | -3 | 0.802 |
MEK5 |
0.725 | -0.239 | 2 | 0.739 |
PKCZ |
0.725 | -0.147 | 2 | 0.684 |
HIPK2 |
0.725 | -0.026 | 1 | 0.547 |
WNK4 |
0.724 | -0.159 | -2 | 0.813 |
CK1D |
0.724 | -0.021 | -3 | 0.473 |
NEK5 |
0.723 | -0.172 | 1 | 0.814 |
DYRK1A |
0.723 | -0.043 | 1 | 0.687 |
P38D |
0.723 | -0.003 | 1 | 0.516 |
CAMKK1 |
0.722 | -0.083 | -2 | 0.716 |
DAPK1 |
0.722 | -0.006 | -3 | 0.765 |
HIPK1 |
0.722 | -0.050 | 1 | 0.661 |
PHKG1 |
0.722 | -0.169 | -3 | 0.798 |
CK1A2 |
0.721 | -0.032 | -3 | 0.475 |
CDK18 |
0.721 | -0.072 | 1 | 0.554 |
SNRK |
0.720 | -0.210 | 2 | 0.583 |
CDK12 |
0.720 | -0.069 | 1 | 0.568 |
MST2 |
0.720 | -0.070 | 1 | 0.813 |
DCAMKL2 |
0.720 | -0.074 | -3 | 0.792 |
EEF2K |
0.719 | -0.086 | 3 | 0.295 |
MST3 |
0.719 | -0.145 | 2 | 0.749 |
CK1G1 |
0.719 | -0.062 | -3 | 0.526 |
CDK17 |
0.718 | -0.067 | 1 | 0.502 |
TTBK1 |
0.718 | -0.087 | 2 | 0.539 |
DYRK1B |
0.718 | -0.031 | 1 | 0.591 |
P70S6K |
0.717 | -0.061 | -3 | 0.703 |
PDHK3_TYR |
0.717 | 0.222 | 4 | 0.749 |
NEK8 |
0.717 | -0.170 | 2 | 0.721 |
CDK9 |
0.716 | -0.094 | 1 | 0.605 |
CAMKK2 |
0.716 | -0.113 | -2 | 0.712 |
AKT1 |
0.716 | -0.042 | -3 | 0.694 |
TAK1 |
0.715 | -0.063 | 1 | 0.825 |
MPSK1 |
0.715 | -0.096 | 1 | 0.763 |
TAO2 |
0.715 | -0.158 | 2 | 0.769 |
GCK |
0.715 | -0.109 | 1 | 0.789 |
DYRK3 |
0.714 | -0.040 | 1 | 0.661 |
ALPHAK3 |
0.714 | 0.083 | -1 | 0.777 |
PKCT |
0.714 | -0.125 | 2 | 0.645 |
IRAK1 |
0.713 | -0.225 | -1 | 0.716 |
SGK1 |
0.713 | 0.009 | -3 | 0.607 |
IRAK4 |
0.712 | -0.236 | 1 | 0.779 |
NEK11 |
0.712 | -0.218 | 1 | 0.789 |
PDHK4_TYR |
0.711 | 0.179 | 2 | 0.826 |
PAK5 |
0.711 | -0.049 | -2 | 0.606 |
PDK1 |
0.711 | -0.122 | 1 | 0.779 |
MAP2K6_TYR |
0.711 | 0.158 | -1 | 0.869 |
TNIK |
0.711 | -0.121 | 3 | 0.269 |
HIPK3 |
0.710 | -0.095 | 1 | 0.653 |
PHKG2 |
0.710 | -0.154 | -3 | 0.780 |
LKB1 |
0.710 | -0.158 | -3 | 0.793 |
PAK4 |
0.709 | -0.048 | -2 | 0.618 |
CDK16 |
0.709 | -0.066 | 1 | 0.521 |
PDHK1_TYR |
0.709 | 0.158 | -1 | 0.887 |
MST1 |
0.708 | -0.112 | 1 | 0.789 |
MINK |
0.708 | -0.160 | 1 | 0.785 |
BMPR2_TYR |
0.707 | 0.085 | -1 | 0.880 |
VRK1 |
0.707 | -0.196 | 2 | 0.774 |
CDK14 |
0.706 | -0.096 | 1 | 0.597 |
TTK |
0.706 | -0.047 | -2 | 0.858 |
SBK |
0.705 | 0.006 | -3 | 0.574 |
MAP2K4_TYR |
0.705 | 0.052 | -1 | 0.858 |
ERK7 |
0.705 | -0.061 | 2 | 0.458 |
MRCKA |
0.704 | -0.049 | -3 | 0.738 |
HGK |
0.704 | -0.182 | 3 | 0.260 |
MAK |
0.704 | -0.009 | -2 | 0.722 |
PKCE |
0.703 | -0.102 | 2 | 0.635 |
MAP3K15 |
0.703 | -0.203 | 1 | 0.779 |
MRCKB |
0.703 | -0.045 | -3 | 0.724 |
ROCK2 |
0.703 | -0.047 | -3 | 0.763 |
NEK4 |
0.703 | -0.231 | 1 | 0.778 |
MEK2 |
0.703 | -0.183 | 2 | 0.723 |
CAMK1A |
0.703 | -0.051 | -3 | 0.650 |
PKCI |
0.703 | -0.150 | 2 | 0.652 |
LRRK2 |
0.703 | -0.216 | 2 | 0.752 |
EPHA6 |
0.702 | 0.008 | -1 | 0.866 |
CHK2 |
0.702 | -0.064 | -3 | 0.630 |
HPK1 |
0.702 | -0.153 | 1 | 0.770 |
AKT3 |
0.701 | -0.040 | -3 | 0.619 |
OSR1 |
0.701 | -0.072 | 2 | 0.707 |
RIPK2 |
0.701 | -0.217 | 1 | 0.762 |
CDK10 |
0.701 | -0.089 | 1 | 0.580 |
MAP2K7_TYR |
0.701 | 0.005 | 2 | 0.789 |
NEK1 |
0.700 | -0.216 | 1 | 0.789 |
TXK |
0.700 | 0.055 | 1 | 0.891 |
EPHA4 |
0.700 | 0.060 | 2 | 0.752 |
FER |
0.700 | 0.050 | 1 | 0.902 |
YANK3 |
0.699 | -0.046 | 2 | 0.365 |
KHS2 |
0.699 | -0.119 | 1 | 0.773 |
TESK1_TYR |
0.699 | -0.105 | 3 | 0.323 |
KHS1 |
0.699 | -0.141 | 1 | 0.765 |
MEKK6 |
0.699 | -0.257 | 1 | 0.793 |
PINK1_TYR |
0.698 | -0.049 | 1 | 0.842 |
SLK |
0.698 | -0.124 | -2 | 0.686 |
CDK4 |
0.698 | -0.083 | 1 | 0.556 |
EPHB4 |
0.698 | -0.021 | -1 | 0.830 |
FYN |
0.697 | 0.089 | -1 | 0.787 |
DMPK1 |
0.697 | -0.035 | -3 | 0.745 |
YES1 |
0.697 | 0.010 | -1 | 0.800 |
INSRR |
0.697 | -0.010 | 3 | 0.226 |
PKN1 |
0.697 | -0.109 | -3 | 0.711 |
PKMYT1_TYR |
0.696 | -0.150 | 3 | 0.291 |
CDK6 |
0.696 | -0.096 | 1 | 0.575 |
SRMS |
0.696 | 0.042 | 1 | 0.892 |
EPHB2 |
0.695 | 0.026 | -1 | 0.812 |
STK33 |
0.695 | -0.158 | 2 | 0.529 |
LOK |
0.695 | -0.180 | -2 | 0.731 |
BLK |
0.694 | 0.022 | -1 | 0.820 |
PBK |
0.694 | -0.088 | 1 | 0.764 |
YSK1 |
0.694 | -0.183 | 2 | 0.712 |
BUB1 |
0.693 | -0.088 | -5 | 0.765 |
MOK |
0.693 | -0.051 | 1 | 0.663 |
EPHB1 |
0.692 | -0.022 | 1 | 0.886 |
CK1A |
0.691 | -0.033 | -3 | 0.385 |
EPHB3 |
0.691 | -0.010 | -1 | 0.812 |
ABL2 |
0.690 | -0.057 | -1 | 0.795 |
BIKE |
0.690 | -0.026 | 1 | 0.724 |
LCK |
0.690 | -0.018 | -1 | 0.808 |
HCK |
0.690 | -0.042 | -1 | 0.798 |
RET |
0.689 | -0.112 | 1 | 0.802 |
CSF1R |
0.689 | -0.107 | 3 | 0.222 |
CRIK |
0.689 | -0.036 | -3 | 0.695 |
DDR1 |
0.688 | -0.111 | 4 | 0.688 |
FGR |
0.688 | -0.075 | 1 | 0.863 |
ROCK1 |
0.688 | -0.062 | -3 | 0.734 |
PKG1 |
0.688 | -0.070 | -2 | 0.576 |
EPHA5 |
0.687 | 0.038 | 2 | 0.744 |
ITK |
0.687 | -0.047 | -1 | 0.764 |
HASPIN |
0.686 | -0.077 | -1 | 0.707 |
ROS1 |
0.686 | -0.186 | 3 | 0.209 |
TYK2 |
0.686 | -0.167 | 1 | 0.801 |
ASK1 |
0.686 | -0.149 | 1 | 0.776 |
EPHA7 |
0.686 | -0.020 | 2 | 0.737 |
TYRO3 |
0.685 | -0.178 | 3 | 0.228 |
FGFR2 |
0.685 | -0.067 | 3 | 0.254 |
BMX |
0.685 | -0.022 | -1 | 0.710 |
MST1R |
0.684 | -0.217 | 3 | 0.231 |
JAK3 |
0.684 | -0.112 | 1 | 0.797 |
PTK2 |
0.684 | 0.067 | -1 | 0.807 |
JAK2 |
0.684 | -0.164 | 1 | 0.799 |
LYN |
0.684 | -0.026 | 3 | 0.206 |
KIT |
0.684 | -0.082 | 3 | 0.228 |
LIMK2_TYR |
0.684 | -0.185 | -3 | 0.855 |
SYK |
0.683 | 0.100 | -1 | 0.805 |
MERTK |
0.683 | -0.039 | 3 | 0.236 |
FLT3 |
0.682 | -0.111 | 3 | 0.222 |
EPHA8 |
0.682 | 0.008 | -1 | 0.816 |
ABL1 |
0.681 | -0.106 | -1 | 0.779 |
EGFR |
0.681 | 0.052 | 1 | 0.705 |
LIMK1_TYR |
0.681 | -0.241 | 2 | 0.769 |
TEC |
0.681 | -0.056 | -1 | 0.694 |
SRC |
0.681 | 0.002 | -1 | 0.773 |
EPHA3 |
0.681 | -0.052 | 2 | 0.713 |
MET |
0.681 | -0.082 | 3 | 0.220 |
STLK3 |
0.680 | -0.099 | 1 | 0.769 |
NTRK1 |
0.680 | -0.059 | -1 | 0.798 |
NEK3 |
0.680 | -0.262 | 1 | 0.754 |
FGFR3 |
0.679 | -0.045 | 3 | 0.244 |
TAO1 |
0.679 | -0.175 | 1 | 0.727 |
TEK |
0.678 | -0.148 | 3 | 0.210 |
TNK2 |
0.678 | -0.158 | 3 | 0.210 |
MYO3A |
0.678 | -0.181 | 1 | 0.760 |
KDR |
0.678 | -0.140 | 3 | 0.213 |
FRK |
0.678 | -0.061 | -1 | 0.825 |
FLT1 |
0.677 | -0.044 | -1 | 0.846 |
ERBB2 |
0.677 | -0.069 | 1 | 0.782 |
MYO3B |
0.677 | -0.194 | 2 | 0.722 |
INSR |
0.677 | -0.093 | 3 | 0.207 |
FGFR1 |
0.676 | -0.138 | 3 | 0.236 |
IGF1R |
0.676 | -0.011 | 3 | 0.197 |
PDGFRB |
0.676 | -0.174 | 3 | 0.227 |
ALK |
0.676 | -0.133 | 3 | 0.202 |
BTK |
0.675 | -0.123 | -1 | 0.716 |
AXL |
0.675 | -0.129 | 3 | 0.227 |
CSK |
0.675 | -0.013 | 2 | 0.732 |
LTK |
0.675 | -0.111 | 3 | 0.215 |
EPHA2 |
0.675 | 0.005 | -1 | 0.790 |
CK1G3 |
0.674 | -0.030 | -3 | 0.337 |
FGFR4 |
0.674 | 0.014 | -1 | 0.766 |
DDR2 |
0.674 | -0.076 | 3 | 0.218 |
NTRK3 |
0.673 | -0.055 | -1 | 0.759 |
PTK2B |
0.673 | -0.067 | -1 | 0.727 |
ERBB4 |
0.672 | 0.009 | 1 | 0.728 |
AAK1 |
0.671 | -0.008 | 1 | 0.614 |
NTRK2 |
0.671 | -0.133 | 3 | 0.216 |
FLT4 |
0.671 | -0.119 | 3 | 0.224 |
PTK6 |
0.671 | -0.082 | -1 | 0.682 |
CK1G2 |
0.670 | -0.031 | -3 | 0.438 |
MATK |
0.669 | -0.052 | -1 | 0.743 |
EPHA1 |
0.669 | -0.140 | 3 | 0.202 |
NEK10_TYR |
0.669 | -0.123 | 1 | 0.674 |
JAK1 |
0.669 | -0.168 | 1 | 0.750 |
TNK1 |
0.667 | -0.195 | 3 | 0.225 |
YANK2 |
0.664 | -0.069 | 2 | 0.387 |
TNNI3K_TYR |
0.664 | -0.170 | 1 | 0.819 |
WEE1_TYR |
0.664 | -0.135 | -1 | 0.725 |
PDGFRA |
0.661 | -0.266 | 3 | 0.218 |
FES |
0.653 | -0.078 | -1 | 0.675 |
ZAP70 |
0.647 | -0.014 | -1 | 0.730 |
MUSK |
0.643 | -0.160 | 1 | 0.679 |