Motif 560 (n=215)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2991 | ochoa | Snf2 related CREBBP activator protein | None |
| A4FU49 | SH3D21 | S336 | ochoa | SH3 domain-containing protein 21 | None |
| A6NHT5 | HMX3 | S185 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| A6NKD9 | CCDC85C | S372 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| E9PAV3 | NACA | S2029 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| H7C1W4 | None | S200 | ochoa | Uncharacterized protein | None |
| O00193 | SMAP | S147 | ochoa | Small acidic protein | None |
| O14646 | CHD1 | S1406 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14979 | HNRNPDL | S127 | ochoa | Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
| O15042 | U2SURP | S767 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15061 | SYNM | S1379 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15488 | GYG2 | S468 | ochoa | Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) | Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. {ECO:0000269|PubMed:9346895, ECO:0000269|PubMed:9857012}. |
| O15527 | OGG1 | S232 | psp | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| O43395 | PRPF3 | S619 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}. |
| O43670 | ZNF207 | S371 | ochoa | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}. |
| O43683 | BUB1 | S250 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43734 | TRAF3IP2 | S36 | ochoa | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}. |
| O43852 | CALU | S125 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60341 | KDM1A | Y136 | ochoa | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| O75362 | ZNF217 | S662 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75683 | SURF6 | S206 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O75923 | DYSF | S1729 | ochoa | Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}. |
| O94782 | USP1 | S471 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O95747 | OXSR1 | S347 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| O95810 | CAVIN2 | S218 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P01833 | PIGR | S735 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
| P04075 | ALDOA | S245 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05060 | CHGB | S263 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05060 | CHGB | S311 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05060 | CHGB | S405 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05408 | SCG5 | S141 | ochoa | Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}. |
| P08833 | IGFBP1 | S194 | ochoa|psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P10244 | MYBL2 | S241 | ochoa|psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P12643 | BMP2 | S117 | ochoa | Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:24362451, PubMed:31019025). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:16771708, PubMed:20851880). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). {ECO:0000250|UniProtKB:P21274, ECO:0000269|PubMed:15064755, ECO:0000269|PubMed:17295905, ECO:0000269|PubMed:18436533, ECO:0000269|PubMed:20851880, ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:31019025, ECO:0000269|PubMed:31800957, ECO:0000269|PubMed:3201241, ECO:0000269|PubMed:7791754}. |
| P12956 | XRCC6 | S560 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P16220 | CREB1 | S142 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
| P16435 | POR | S68 | ochoa | NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) | This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}. |
| P18583 | SON | S1783 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19532 | TFE3 | S334 | ochoa | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
| P23497 | SP100 | S410 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P25325 | MPST | S225 | ochoa | 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) | Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. {ECO:0000250|UniProtKB:P97532}. |
| P26358 | DNMT1 | S394 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P28290 | ITPRID2 | S1174 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28290 | ITPRID2 | S1175 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28715 | ERCC5 | S453 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29374 | ARID4A | S427 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30414 | NKTR | S1061 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P35269 | GTF2F1 | S311 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P36383 | GJC1 | S326 | ochoa | Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P42166 | TMPO | S436 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P43243 | MATR3 | S264 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48681 | NES | S1175 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S1282 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S428 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P50851 | LRBA | S1236 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P53985 | SLC16A1 | S461 | ochoa | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) | Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}. |
| P55072 | VCP | S197 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q01484 | ANK2 | S1736 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S3764 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01804 | OTUD4 | S1024 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q01860 | POU5F1 | S93 | psp | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
| Q01968 | OCRL | S709 | ochoa | Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) | Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:25869668, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:15474001, ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:7761412, ECO:0000269|PubMed:9430698}. |
| Q02224 | CENPE | S2389 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q02952 | AKAP12 | S803 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03111 | MLLT1 | S359 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q03164 | KMT2A | S2508 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08945 | SSRP1 | S688 | psp | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q12872 | SFSWAP | S610 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12906 | ILF3 | S482 | ochoa|psp | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13029 | PRDM2 | S1256 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13136 | PPFIA1 | S244 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13315 | ATM | S1993 | ochoa | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13428 | TCOF1 | S417 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S482 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S765 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S769 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S875 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13459 | MYO9B | S1114 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13546 | RIPK1 | S296 | ochoa|psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13547 | HDAC1 | S393 | ochoa | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q13615 | MTMR3 | S701 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13765 | NACA | S166 | psp | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| Q14151 | SAFB2 | S207 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14151 | SAFB2 | S233 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14151 | SAFB2 | S330 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14315 | FLNC | S762 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14457 | BECN1 | S64 | ochoa | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}. |
| Q14684 | RRP1B | S458 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14D04 | VEPH1 | S529 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15021 | NCAPD2 | S1370 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15424 | SAFB | S234 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15424 | SAFB | S331 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15435 | PPP1R7 | S27 | ochoa|psp | Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) | Regulatory subunit of protein phosphatase 1. {ECO:0000250}. |
| Q16288 | NTRK3 | S472 | ochoa | NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}. |
| Q16625 | OCLN | S471 | psp | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2TAL5 | SMTNL2 | S141 | ochoa | Smoothelin-like protein 2 | None |
| Q53T59 | HS1BP3 | S194 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q562E7 | WDR81 | S1118 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q567U6 | CCDC93 | S301 | ochoa | Coiled-coil domain-containing protein 93 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| Q5BKX8 | CAVIN4 | S315 | ochoa | Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) | Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}. |
| Q5QJE6 | DNTTIP2 | Y135 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S654 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T1M5 | FKBP15 | S1139 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5VZ89 | DENND4C | S1606 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5VZK9 | CARMIL1 | S1135 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68D51 | DENND2C | S445 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6AWC2 | WWC2 | S883 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6P0N0 | MIS18BP1 | S776 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P0N0 | MIS18BP1 | S824 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P4F7 | ARHGAP11A | S638 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PJG2 | MIDEAS | S898 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6WN34 | CHRDL2 | S182 | ochoa | Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) | May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}. |
| Q6ZRI8 | ARHGAP36 | S479 | ochoa | Rho GTPase-activating protein 36 | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q6ZRS2 | SRCAP | S3168 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7Z5K2 | WAPL | S380 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z5K2 | WAPL | S1076 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6Z7 | HUWE1 | S1736 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86SQ0 | PHLDB2 | S493 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86W92 | PPFIBP1 | S434 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IX12 | CCAR1 | S992 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8IX90 | SKA3 | S124 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8N1F7 | NUP93 | S726 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N3D4 | EHBP1L1 | S998 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3K9 | CMYA5 | S3294 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3S3 | PHTF2 | S335 | ochoa | Protein PHTF2 | None |
| Q8N5B7 | CERS5 | S355 | ochoa|psp | Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
| Q8N9T8 | KRI1 | S171 | ochoa | Protein KRI1 homolog | None |
| Q8N9T8 | KRI1 | S536 | ochoa | Protein KRI1 homolog | None |
| Q8NBU5 | ATAD1 | S322 | ochoa | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) | Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q9D5T0, ECO:0000269|PubMed:24843043}. |
| Q8NDX5 | PHC3 | S862 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEM0 | MCPH1 | S548 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NEZ4 | KMT2C | S89 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NI27 | THOC2 | S1364 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAD7 | OCC1 | S28 | ochoa | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | None |
| Q8TBB5 | KLHDC4 | S418 | ochoa | Kelch domain-containing protein 4 | None |
| Q8WW12 | PCNP | S53 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WXF7 | ATL1 | S22 | ochoa|psp | Atlastin-1 (ATL-1) (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A) | Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:14506257, PubMed:18270207, PubMed:19665976, PubMed:27619977, PubMed:34817557, PubMed:38509071). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (PubMed:14506257, PubMed:21220294, PubMed:21368113, PubMed:23334294, PubMed:38509071). May also regulate more or less directly Golgi biogenesis (PubMed:17321752). Indirectly regulates axonal development (By similarity). {ECO:0000250|UniProtKB:Q6PST4, ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:21368113, ECO:0000269|PubMed:23334294, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557, ECO:0000269|PubMed:38509071}. |
| Q8WXI7 | MUC16 | S6984 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92540 | SMG7 | S510 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92543 | SNX19 | S705 | ochoa | Sorting nexin-19 | Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}. |
| Q92890 | UFD1 | S209 | ochoa | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| Q93075 | TATDN2 | S257 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96C86 | DCPS | S24 | ochoa | m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172, ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679, ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270, ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. |
| Q96EB6 | SIRT1 | S162 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96EV2 | RBM33 | S205 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96GX5 | MASTL | S598 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96GX5 | MASTL | S602 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96JG8 | MAGED4 | S359 | ochoa | Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| Q96KC8 | DNAJC1 | S484 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96PY6 | NEK1 | Y1125 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RY5 | CRAMP1 | S27 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96T58 | SPEN | S2416 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99543 | DNAJC2 | S63 | ochoa | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| Q99590 | SCAF11 | S680 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BSI4 | TINF2 | S305 | ochoa | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}. |
| Q9BU64 | CENPO | S263 | ochoa | Centromere protein O (CENP-O) (Interphase centromere complex protein 36) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}. |
| Q9BV36 | MLPH | S402 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BV36 | MLPH | S484 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BV44 | THUMPD3 | S216 | ochoa | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-) | Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960). {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}. |
| Q9BVS4 | RIOK2 | S380 | ochoa|psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BW71 | HIRIP3 | S159 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BW71 | HIRIP3 | S199 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXK5 | BCL2L13 | S420 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BY89 | KIAA1671 | S1701 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H009 | NACA2 | S166 | ochoa | Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| Q9H2J7 | SLC6A15 | S55 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H3C7 | GGNBP2 | S360 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H3R0 | KDM4C | S428 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H582 | ZNF644 | S394 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H5J8 | TAF1D | S211 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6A9 | PCNX3 | S1025 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6S3 | EPS8L2 | S240 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H6W3 | RIOX1 | S66 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H6X2 | ANTXR1 | S362 | ochoa | Anthrax toxin receptor 1 (Tumor endothelial marker 8) | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478). {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269|PubMed:11700562, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:20585457}.; FUNCTION: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. {ECO:0000269|PubMed:33924774}. |
| Q9H9J4 | USP42 | S759 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HCB6 | SPON1 | S747 | ochoa | Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) | Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}. |
| Q9NPC7 | MYNN | S289 | ochoa | Myoneurin (Zinc finger and BTB domain-containing protein 31) | None |
| Q9NQB0 | TCF7L2 | S31 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NQB0 | TCF7L2 | S82 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NQZ2 | UTP3 | S396 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9NR30 | DDX21 | S121 | ochoa|psp | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NW68 | BSDC1 | S313 | ochoa | BSD domain-containing protein 1 | None |
| Q9NWH9 | SLTM | S904 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9P1Y5 | CAMSAP3 | S870 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P244 | LRFN1 | S659 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P2E9 | RRBP1 | S37 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UBN7 | HDAC6 | S458 | psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UDY2 | TJP2 | S1067 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHH9 | IP6K2 | S359 | psp | Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}. |
| Q9UKL3 | CASP8AP2 | S1270 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9ULW3 | ABT1 | S32 | ochoa | Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) | Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}. |
| Q9UPV0 | CEP164 | S359 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2J2 | EPB41L3 | S833 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2K7 | KDM2A | S692 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2W1 | THRAP3 | S494 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3R5 | DOP1B | S654 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y3R5 | DOP1B | S1085 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y4A5 | TRRAP | S2554 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| Q9Y4D1 | DAAM1 | S1027 | ochoa | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| Q9Y4D1 | DAAM1 | S1030 | ochoa | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| Q9Y4L1 | HYOU1 | S567 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y5A6 | ZSCAN21 | S208 | ochoa | Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) | Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}. |
| R4GMW8 | BIVM-ERCC5 | S907 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q6UXH1 | CRELD2 | S295 | Sugiyama | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| O60566 | BUB1B | S411 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9UMY4 | SNX12 | S114 | Sugiyama | Sorting nexin-12 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
| P11168 | SLC2A2 | S491 | ELM|iPTMNet|EPSD | Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}. |
| Q76KP1 | B4GALNT4 | S79 | Sugiyama | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (NGalNAc-T1) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4) | Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. |
| P31946 | YWHAB | S158 | Sugiyama | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P51151 | RAB9A | S134 | Sugiyama | Ras-related protein Rab-9A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:34793709}. |
| Q13111 | CHAF1A | S806 | Sugiyama | Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}. |
| Q9BRK5 | SDF4 | S142 | Sugiyama | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Q9BSV6 | TSEN34 | S93 | Sugiyama | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q96RR4 | CAMKK2 | S503 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q9Y2T3 | GDA | S49 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9656249 | Defective Base Excision Repair Associated with OGG1 | 0.000866 | 3.063 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.002996 | 2.523 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.002361 | 2.627 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.007572 | 2.121 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.003368 | 2.473 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005878 | 2.231 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.002996 | 2.523 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007371 | 2.132 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.002595 | 2.586 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 0.005878 | 2.231 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.005569 | 2.254 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.007872 | 2.104 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.002977 | 2.526 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.006442 | 2.191 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.003566 | 2.448 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.007271 | 2.138 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.007271 | 2.138 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.005284 | 2.277 |
| R-HSA-4839726 | Chromatin organization | 0.005287 | 2.277 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.005398 | 2.268 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.005029 | 2.299 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.008636 | 2.064 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.008537 | 2.069 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.009017 | 2.045 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.010811 | 1.966 |
| R-HSA-3214842 | HDMs demethylate histones | 0.009966 | 2.001 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.010767 | 1.968 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.010850 | 1.965 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.010811 | 1.966 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.012680 | 1.897 |
| R-HSA-3371556 | Cellular response to heat stress | 0.012912 | 1.889 |
| R-HSA-9656255 | Defective OGG1 Substrate Binding | 0.013998 | 1.854 |
| R-HSA-9657050 | Defective OGG1 Localization | 0.013998 | 1.854 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.014824 | 1.829 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.014824 | 1.829 |
| R-HSA-1640170 | Cell Cycle | 0.015851 | 1.800 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.017093 | 1.767 |
| R-HSA-1538133 | G0 and Early G1 | 0.017093 | 1.767 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.016310 | 1.788 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.018291 | 1.738 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.018477 | 1.733 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.020266 | 1.693 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.020785 | 1.682 |
| R-HSA-4641265 | Repression of WNT target genes | 0.021847 | 1.661 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.026441 | 1.578 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.026411 | 1.578 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.026411 | 1.578 |
| R-HSA-73927 | Depurination | 0.026441 | 1.578 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.024221 | 1.616 |
| R-HSA-9656256 | Defective OGG1 Substrate Processing | 0.027801 | 1.556 |
| R-HSA-68886 | M Phase | 0.029025 | 1.537 |
| R-HSA-201556 | Signaling by ALK | 0.027959 | 1.553 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 0.041412 | 1.383 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.041412 | 1.383 |
| R-HSA-9034013 | NTF3 activates NTRK3 signaling | 0.054833 | 1.261 |
| R-HSA-3858516 | Glycogen storage disease type 0 (liver GYS2) | 0.054833 | 1.261 |
| R-HSA-3878781 | Glycogen storage disease type IV (GBE1) | 0.054833 | 1.261 |
| R-HSA-5619098 | Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) | 0.054833 | 1.261 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.068067 | 1.167 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.081117 | 1.091 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.106673 | 0.972 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.119184 | 0.924 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.131521 | 0.881 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.131521 | 0.881 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.131521 | 0.881 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.131521 | 0.881 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.131521 | 0.881 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.131521 | 0.881 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.131521 | 0.881 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.131521 | 0.881 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.143685 | 0.843 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.143685 | 0.843 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.155680 | 0.808 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.167508 | 0.776 |
| R-HSA-164843 | 2-LTR circle formation | 0.167508 | 0.776 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.179171 | 0.747 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.179171 | 0.747 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.190671 | 0.720 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.190671 | 0.720 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.202011 | 0.695 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.079678 | 1.099 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.079678 | 1.099 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.083826 | 1.077 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.083826 | 1.077 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.235089 | 0.629 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.235089 | 0.629 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.053902 | 1.268 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.245809 | 0.609 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.245809 | 0.609 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.056079 | 1.251 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.256380 | 0.591 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.256380 | 0.591 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.067577 | 1.170 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.266803 | 0.574 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.266803 | 0.574 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.045135 | 1.345 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.045135 | 1.345 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.142727 | 0.845 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.287214 | 0.542 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.287214 | 0.542 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.287214 | 0.542 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.297207 | 0.527 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.297207 | 0.527 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.297207 | 0.527 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.297207 | 0.527 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.307060 | 0.513 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.307060 | 0.513 |
| R-HSA-774815 | Nucleosome assembly | 0.172193 | 0.764 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.172193 | 0.764 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.316775 | 0.499 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.187277 | 0.728 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.326355 | 0.486 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.335802 | 0.474 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.335802 | 0.474 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.335802 | 0.474 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.212785 | 0.672 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.354300 | 0.451 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.372286 | 0.429 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.372286 | 0.429 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.372286 | 0.429 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.372286 | 0.429 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.248975 | 0.604 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.381091 | 0.419 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.381091 | 0.419 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.389772 | 0.409 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.389772 | 0.409 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.199980 | 0.699 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.316387 | 0.500 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.362319 | 0.441 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.277611 | 0.557 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.353353 | 0.452 |
| R-HSA-72172 | mRNA Splicing | 0.388290 | 0.411 |
| R-HSA-167172 | Transcription of the HIV genome | 0.290530 | 0.537 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.248083 | 0.605 |
| R-HSA-167169 | HIV Transcription Elongation | 0.142727 | 0.845 |
| R-HSA-72086 | mRNA Capping | 0.389772 | 0.409 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.075597 | 1.121 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.142727 | 0.845 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.073365 | 1.135 |
| R-HSA-9664873 | Pexophagy | 0.167508 | 0.776 |
| R-HSA-73886 | Chromosome Maintenance | 0.296994 | 0.527 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.128442 | 0.891 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.137928 | 0.860 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.381091 | 0.419 |
| R-HSA-199920 | CREB phosphorylation | 0.119184 | 0.924 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.155680 | 0.808 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.190671 | 0.720 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.235089 | 0.629 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.256380 | 0.591 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.372286 | 0.429 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.110646 | 0.956 |
| R-HSA-8849473 | PTK6 Expression | 0.131521 | 0.881 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.034485 | 1.462 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.256380 | 0.591 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.354300 | 0.451 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.122733 | 0.911 |
| R-HSA-68877 | Mitotic Prometaphase | 0.031943 | 1.496 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.093450 | 1.029 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.043612 | 1.360 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.081117 | 1.091 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.116630 | 0.933 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.147562 | 0.831 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.245809 | 0.609 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.334288 | 0.476 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.068067 | 1.167 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.143685 | 0.843 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.143685 | 0.843 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.155680 | 0.808 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.167508 | 0.776 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.190671 | 0.720 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.202011 | 0.695 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.224218 | 0.649 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.235089 | 0.629 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.245809 | 0.609 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.277080 | 0.557 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.277080 | 0.557 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.142727 | 0.845 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.287214 | 0.542 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.077163 | 1.113 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.345116 | 0.462 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.254168 | 0.595 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.114456 | 0.941 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.277080 | 0.557 |
| R-HSA-201451 | Signaling by BMP | 0.372286 | 0.429 |
| R-HSA-9646399 | Aggrephagy | 0.142727 | 0.845 |
| R-HSA-170968 | Frs2-mediated activation | 0.213192 | 0.671 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.045703 | 1.340 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.147562 | 0.831 |
| R-HSA-9843745 | Adipogenesis | 0.342952 | 0.465 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.131521 | 0.881 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.259364 | 0.586 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.306065 | 0.514 |
| R-HSA-162587 | HIV Life Cycle | 0.234757 | 0.629 |
| R-HSA-3295583 | TRP channels | 0.363356 | 0.440 |
| R-HSA-169893 | Prolonged ERK activation events | 0.245809 | 0.609 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.335802 | 0.474 |
| R-HSA-3322077 | Glycogen synthesis | 0.297207 | 0.527 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.155680 | 0.808 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.235089 | 0.629 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.277080 | 0.557 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.326355 | 0.486 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.116623 | 0.933 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.142727 | 0.845 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.142727 | 0.845 |
| R-HSA-376172 | DSCAM interactions | 0.054833 | 1.261 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.106673 | 0.972 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.143685 | 0.843 |
| R-HSA-170984 | ARMS-mediated activation | 0.155680 | 0.808 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.179171 | 0.747 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.190671 | 0.720 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.235089 | 0.629 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.128442 | 0.891 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.287214 | 0.542 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.307060 | 0.513 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.345116 | 0.462 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.381091 | 0.419 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.321535 | 0.493 |
| R-HSA-9612973 | Autophagy | 0.101517 | 0.993 |
| R-HSA-9663891 | Selective autophagy | 0.158220 | 0.801 |
| R-HSA-73894 | DNA Repair | 0.091378 | 1.039 |
| R-HSA-1500620 | Meiosis | 0.377386 | 0.423 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.233420 | 0.632 |
| R-HSA-9909396 | Circadian clock | 0.346780 | 0.460 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.039106 | 1.408 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.119120 | 0.924 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.137928 | 0.860 |
| R-HSA-9675135 | Diseases of DNA repair | 0.041729 | 1.380 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.363356 | 0.440 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.155680 | 0.808 |
| R-HSA-392517 | Rap1 signalling | 0.287214 | 0.542 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.307060 | 0.513 |
| R-HSA-983189 | Kinesins | 0.248975 | 0.604 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.259364 | 0.586 |
| R-HSA-5334118 | DNA methylation | 0.389772 | 0.409 |
| R-HSA-8953854 | Metabolism of RNA | 0.229150 | 0.640 |
| R-HSA-1632852 | Macroautophagy | 0.074513 | 1.128 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.099748 | 1.001 |
| R-HSA-9834899 | Specification of the neural plate border | 0.287214 | 0.542 |
| R-HSA-111933 | Calmodulin induced events | 0.123760 | 0.907 |
| R-HSA-112307 | Transmission across Electrical Synapses | 0.081117 | 1.091 |
| R-HSA-112303 | Electric Transmission Across Gap Junctions | 0.081117 | 1.091 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.045703 | 1.340 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.155680 | 0.808 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.235089 | 0.629 |
| R-HSA-111997 | CaM pathway | 0.123760 | 0.907 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.326355 | 0.486 |
| R-HSA-429947 | Deadenylation of mRNA | 0.345116 | 0.462 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.354300 | 0.451 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.354300 | 0.451 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.363356 | 0.440 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.077483 | 1.111 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.200876 | 0.697 |
| R-HSA-68875 | Mitotic Prophase | 0.122626 | 0.911 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.202011 | 0.695 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.202011 | 0.695 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.087986 | 1.056 |
| R-HSA-111996 | Ca-dependent events | 0.157328 | 0.803 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.300893 | 0.522 |
| R-HSA-162592 | Integration of provirus | 0.190671 | 0.720 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.075597 | 1.121 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.128442 | 0.891 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.128442 | 0.891 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.172193 | 0.764 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.136617 | 0.864 |
| R-HSA-74160 | Gene expression (Transcription) | 0.304119 | 0.517 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.054257 | 1.266 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.106673 | 0.972 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.179171 | 0.747 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.202011 | 0.695 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.202011 | 0.695 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.202011 | 0.695 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.213192 | 0.671 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.235089 | 0.629 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.235089 | 0.629 |
| R-HSA-3229121 | Glycogen storage diseases | 0.266803 | 0.574 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.093310 | 1.030 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.056151 | 1.251 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.363356 | 0.440 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.243785 | 0.613 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.316387 | 0.500 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.387349 | 0.412 |
| R-HSA-68882 | Mitotic Anaphase | 0.051428 | 1.289 |
| R-HSA-112043 | PLC beta mediated events | 0.254168 | 0.595 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.389772 | 0.409 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.326674 | 0.486 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.301161 | 0.521 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.277080 | 0.557 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.052373 | 1.281 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.058297 | 1.234 |
| R-HSA-8963676 | Intestinal absorption | 0.143685 | 0.843 |
| R-HSA-5689877 | Josephin domain DUBs | 0.167508 | 0.776 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.213192 | 0.671 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.256380 | 0.591 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.277080 | 0.557 |
| R-HSA-1474165 | Reproduction | 0.152716 | 0.816 |
| R-HSA-5688426 | Deubiquitination | 0.096427 | 1.016 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.297207 | 0.527 |
| R-HSA-9659379 | Sensory processing of sound | 0.347119 | 0.460 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.056295 | 1.250 |
| R-HSA-73893 | DNA Damage Bypass | 0.047622 | 1.322 |
| R-HSA-112040 | G-protein mediated events | 0.285342 | 0.545 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.083826 | 1.077 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.235089 | 0.629 |
| R-HSA-3371511 | HSF1 activation | 0.123760 | 0.907 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.266803 | 0.574 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.316775 | 0.499 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.389772 | 0.409 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.290530 | 0.537 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.300893 | 0.522 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.266555 | 0.574 |
| R-HSA-8939211 | ESR-mediated signaling | 0.030599 | 1.514 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.058432 | 1.233 |
| R-HSA-212436 | Generic Transcription Pathway | 0.294011 | 0.532 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.147562 | 0.831 |
| R-HSA-2028269 | Signaling by Hippo | 0.039106 | 1.408 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.307060 | 0.513 |
| R-HSA-112316 | Neuronal System | 0.385135 | 0.414 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.172193 | 0.764 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.131521 | 0.881 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.228248 | 0.642 |
| R-HSA-9758941 | Gastrulation | 0.211053 | 0.676 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.352200 | 0.453 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.283842 | 0.547 |
| R-HSA-73884 | Base Excision Repair | 0.164984 | 0.783 |
| R-HSA-9707616 | Heme signaling | 0.259364 | 0.586 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.372425 | 0.429 |
| R-HSA-1483255 | PI Metabolism | 0.214445 | 0.669 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.155680 | 0.808 |
| R-HSA-8876725 | Protein methylation | 0.235089 | 0.629 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.287214 | 0.542 |
| R-HSA-189200 | Cellular hexose transport | 0.326355 | 0.486 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.259364 | 0.586 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.039106 | 1.408 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.251495 | 0.599 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.243809 | 0.613 |
| R-HSA-9842663 | Signaling by LTK | 0.202011 | 0.695 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.235089 | 0.629 |
| R-HSA-9678110 | Attachment and Entry | 0.245809 | 0.609 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.157328 | 0.803 |
| R-HSA-9629569 | Protein hydroxylation | 0.297207 | 0.527 |
| R-HSA-210991 | Basigin interactions | 0.307060 | 0.513 |
| R-HSA-73928 | Depyrimidination | 0.157328 | 0.803 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.114526 | 0.941 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.148243 | 0.829 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.175901 | 0.755 |
| R-HSA-381042 | PERK regulates gene expression | 0.119120 | 0.924 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.266803 | 0.574 |
| R-HSA-9694614 | Attachment and Entry | 0.316775 | 0.499 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.207654 | 0.683 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.363356 | 0.440 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.032994 | 1.482 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.085691 | 1.067 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.088039 | 1.055 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.277080 | 0.557 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.297207 | 0.527 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.300893 | 0.522 |
| R-HSA-913531 | Interferon Signaling | 0.344221 | 0.463 |
| R-HSA-418990 | Adherens junctions interactions | 0.122315 | 0.913 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.307060 | 0.513 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.136910 | 0.864 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.136910 | 0.864 |
| R-HSA-421270 | Cell-cell junction organization | 0.185942 | 0.731 |
| R-HSA-446728 | Cell junction organization | 0.130701 | 0.884 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.105482 | 0.977 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.147562 | 0.831 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.326355 | 0.486 |
| R-HSA-6807070 | PTEN Regulation | 0.179699 | 0.745 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.249433 | 0.603 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.285988 | 0.544 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.235089 | 0.629 |
| R-HSA-1500931 | Cell-Cell communication | 0.198545 | 0.702 |
| R-HSA-109581 | Apoptosis | 0.249887 | 0.602 |
| R-HSA-190861 | Gap junction assembly | 0.114526 | 0.941 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.245809 | 0.609 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.281737 | 0.550 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.047622 | 1.322 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.335802 | 0.474 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.090877 | 1.042 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.101037 | 0.996 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.287214 | 0.542 |
| R-HSA-190828 | Gap junction trafficking | 0.167212 | 0.777 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.072454 | 1.140 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.072454 | 1.140 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.072454 | 1.140 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.072454 | 1.140 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.167212 | 0.777 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.046591 | 1.332 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.192346 | 0.716 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.381091 | 0.419 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.372286 | 0.429 |
| R-HSA-186712 | Regulation of beta-cell development | 0.243785 | 0.613 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.055868 | 1.253 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.293228 | 0.533 |
| R-HSA-75153 | Apoptotic execution phase | 0.177199 | 0.752 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.277080 | 0.557 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.326355 | 0.486 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.274955 | 0.561 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.238600 | 0.622 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.072454 | 1.140 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.116630 | 0.933 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.331802 | 0.479 |
| R-HSA-5357801 | Programmed Cell Death | 0.391457 | 0.407 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.392305 | 0.406 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.392305 | 0.406 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.392461 | 0.406 |
| R-HSA-2262752 | Cellular responses to stress | 0.394491 | 0.404 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.397242 | 0.401 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.398333 | 0.400 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.398333 | 0.400 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.406774 | 0.391 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.406774 | 0.391 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.406774 | 0.391 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.407527 | 0.390 |
| R-HSA-166520 | Signaling by NTRKs | 0.415020 | 0.382 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.415097 | 0.382 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.415097 | 0.382 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.423304 | 0.373 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.423304 | 0.373 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.423304 | 0.373 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.423304 | 0.373 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.423304 | 0.373 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.423304 | 0.373 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.423304 | 0.373 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.423304 | 0.373 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.423304 | 0.373 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.423304 | 0.373 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.423304 | 0.373 |
| R-HSA-9679506 | SARS-CoV Infections | 0.424452 | 0.372 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.431396 | 0.365 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.431396 | 0.365 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.431396 | 0.365 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.431396 | 0.365 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.431396 | 0.365 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.431396 | 0.365 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.437308 | 0.359 |
| R-HSA-73887 | Death Receptor Signaling | 0.437308 | 0.359 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.437308 | 0.359 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.439375 | 0.357 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.439375 | 0.357 |
| R-HSA-5673000 | RAF activation | 0.439375 | 0.357 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.439375 | 0.357 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.439375 | 0.357 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.439375 | 0.357 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.439375 | 0.357 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.439375 | 0.357 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.439375 | 0.357 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.440797 | 0.356 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.445532 | 0.351 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.447243 | 0.349 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.447243 | 0.349 |
| R-HSA-187687 | Signalling to ERKs | 0.447243 | 0.349 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.447243 | 0.349 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.455001 | 0.342 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.455001 | 0.342 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.455001 | 0.342 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.455001 | 0.342 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.455001 | 0.342 |
| R-HSA-3214847 | HATs acetylate histones | 0.459600 | 0.338 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.459600 | 0.338 |
| R-HSA-162906 | HIV Infection | 0.460261 | 0.337 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.462650 | 0.335 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.462650 | 0.335 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.462650 | 0.335 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.462650 | 0.335 |
| R-HSA-70171 | Glycolysis | 0.464243 | 0.333 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.470193 | 0.328 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.470193 | 0.328 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.470193 | 0.328 |
| R-HSA-1566948 | Elastic fibre formation | 0.470193 | 0.328 |
| R-HSA-199991 | Membrane Trafficking | 0.470338 | 0.328 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.473459 | 0.325 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.473459 | 0.325 |
| R-HSA-72312 | rRNA processing | 0.475559 | 0.323 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.477630 | 0.321 |
| R-HSA-69541 | Stabilization of p53 | 0.477630 | 0.321 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.477630 | 0.321 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.477630 | 0.321 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.477630 | 0.321 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.477630 | 0.321 |
| R-HSA-111885 | Opioid Signalling | 0.482580 | 0.316 |
| R-HSA-5619102 | SLC transporter disorders | 0.484432 | 0.315 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.484963 | 0.314 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.484963 | 0.314 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.484963 | 0.314 |
| R-HSA-8982491 | Glycogen metabolism | 0.484963 | 0.314 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.484963 | 0.314 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.484963 | 0.314 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.484963 | 0.314 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.491603 | 0.308 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.492193 | 0.308 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.492193 | 0.308 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.492193 | 0.308 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.492193 | 0.308 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.496077 | 0.304 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.499323 | 0.302 |
| R-HSA-167161 | HIV Transcription Initiation | 0.499323 | 0.302 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.499323 | 0.302 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.499323 | 0.302 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.499323 | 0.302 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.499323 | 0.302 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.499323 | 0.302 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.499323 | 0.302 |
| R-HSA-157118 | Signaling by NOTCH | 0.499688 | 0.301 |
| R-HSA-597592 | Post-translational protein modification | 0.504324 | 0.297 |
| R-HSA-165159 | MTOR signalling | 0.506353 | 0.296 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.506353 | 0.296 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.513284 | 0.290 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.513284 | 0.290 |
| R-HSA-9710421 | Defective pyroptosis | 0.513284 | 0.290 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.513723 | 0.289 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.513723 | 0.289 |
| R-HSA-373752 | Netrin-1 signaling | 0.520119 | 0.284 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.520405 | 0.284 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.526858 | 0.278 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.526858 | 0.278 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.526858 | 0.278 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.526858 | 0.278 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.526858 | 0.278 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.526858 | 0.278 |
| R-HSA-2559583 | Cellular Senescence | 0.532990 | 0.273 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.533503 | 0.273 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.533503 | 0.273 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.533503 | 0.273 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.533503 | 0.273 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.533503 | 0.273 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.533503 | 0.273 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.533503 | 0.273 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.533503 | 0.273 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.533503 | 0.273 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.533503 | 0.273 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.540055 | 0.268 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.543060 | 0.265 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.543611 | 0.265 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.546436 | 0.262 |
| R-HSA-5620924 | Intraflagellar transport | 0.546515 | 0.262 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.546515 | 0.262 |
| R-HSA-70263 | Gluconeogenesis | 0.546515 | 0.262 |
| R-HSA-70326 | Glucose metabolism | 0.551913 | 0.258 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.552885 | 0.257 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.552885 | 0.257 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.552885 | 0.257 |
| R-HSA-69275 | G2/M Transition | 0.553005 | 0.257 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.556025 | 0.255 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.559166 | 0.252 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.559563 | 0.252 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.560110 | 0.252 |
| R-HSA-912446 | Meiotic recombination | 0.565359 | 0.248 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.565359 | 0.248 |
| R-HSA-5617833 | Cilium Assembly | 0.566064 | 0.247 |
| R-HSA-72187 | mRNA 3'-end processing | 0.571466 | 0.243 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.571466 | 0.243 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.571466 | 0.243 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.571466 | 0.243 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.571466 | 0.243 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.571466 | 0.243 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.571466 | 0.243 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.576181 | 0.239 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.576181 | 0.239 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.577487 | 0.238 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.577487 | 0.238 |
| R-HSA-1221632 | Meiotic synapsis | 0.577487 | 0.238 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.577487 | 0.238 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.581157 | 0.236 |
| R-HSA-72649 | Translation initiation complex formation | 0.583424 | 0.234 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.587952 | 0.231 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.587952 | 0.231 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.587952 | 0.231 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.589277 | 0.230 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.595049 | 0.225 |
| R-HSA-75893 | TNF signaling | 0.595049 | 0.225 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.595049 | 0.225 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.595049 | 0.225 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.595049 | 0.225 |
| R-HSA-114608 | Platelet degranulation | 0.595664 | 0.225 |
| R-HSA-69481 | G2/M Checkpoints | 0.595664 | 0.225 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.597677 | 0.224 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.599480 | 0.222 |
| R-HSA-5621480 | Dectin-2 family | 0.600740 | 0.221 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.600740 | 0.221 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.606352 | 0.217 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.606352 | 0.217 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.606352 | 0.217 |
| R-HSA-180786 | Extension of Telomeres | 0.611885 | 0.213 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.611885 | 0.213 |
| R-HSA-191859 | snRNP Assembly | 0.611885 | 0.213 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.611885 | 0.213 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.611885 | 0.213 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.617340 | 0.209 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.617340 | 0.209 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.618153 | 0.209 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.621807 | 0.206 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.622719 | 0.206 |
| R-HSA-450294 | MAP kinase activation | 0.622719 | 0.206 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.622719 | 0.206 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.623967 | 0.205 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.628023 | 0.202 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.628023 | 0.202 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.633253 | 0.198 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.633253 | 0.198 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.633253 | 0.198 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.633253 | 0.198 |
| R-HSA-8848021 | Signaling by PTK6 | 0.633253 | 0.198 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.633253 | 0.198 |
| R-HSA-8963743 | Digestion and absorption | 0.633253 | 0.198 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.636153 | 0.196 |
| R-HSA-5173105 | O-linked glycosylation | 0.639673 | 0.194 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.643166 | 0.192 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.643493 | 0.191 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.648506 | 0.188 |
| R-HSA-1483257 | Phospholipid metabolism | 0.650011 | 0.187 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.653449 | 0.185 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.653449 | 0.185 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.653449 | 0.185 |
| R-HSA-195721 | Signaling by WNT | 0.657299 | 0.182 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.658323 | 0.182 |
| R-HSA-5218859 | Regulated Necrosis | 0.658323 | 0.182 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.660232 | 0.180 |
| R-HSA-8951664 | Neddylation | 0.661777 | 0.179 |
| R-HSA-448424 | Interleukin-17 signaling | 0.667867 | 0.175 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.672538 | 0.172 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.672538 | 0.172 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.672538 | 0.172 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.673345 | 0.172 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.677145 | 0.169 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.677145 | 0.169 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.677145 | 0.169 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.677145 | 0.169 |
| R-HSA-74259 | Purine catabolism | 0.677145 | 0.169 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.679844 | 0.168 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.680562 | 0.167 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.681686 | 0.166 |
| R-HSA-4086398 | Ca2+ pathway | 0.681686 | 0.166 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.681686 | 0.166 |
| R-HSA-9749641 | Aspirin ADME | 0.681686 | 0.166 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.686165 | 0.164 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.689300 | 0.162 |
| R-HSA-380287 | Centrosome maturation | 0.690580 | 0.161 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.690580 | 0.161 |
| R-HSA-8852135 | Protein ubiquitination | 0.690580 | 0.161 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.690580 | 0.161 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.695476 | 0.158 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.699226 | 0.155 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.701551 | 0.154 |
| R-HSA-5619084 | ABC transporter disorders | 0.703459 | 0.153 |
| R-HSA-4086400 | PCP/CE pathway | 0.703459 | 0.153 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.703459 | 0.153 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.707600 | 0.150 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.707632 | 0.150 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.711747 | 0.148 |
| R-HSA-9833482 | PKR-mediated signaling | 0.711747 | 0.148 |
| R-HSA-877300 | Interferon gamma signaling | 0.713400 | 0.147 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.715804 | 0.145 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.715804 | 0.145 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.716300 | 0.145 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.727637 | 0.138 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.727637 | 0.138 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.727637 | 0.138 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.731472 | 0.136 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.735252 | 0.134 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.738980 | 0.131 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.738980 | 0.131 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.738980 | 0.131 |
| R-HSA-70268 | Pyruvate metabolism | 0.742655 | 0.129 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.746279 | 0.127 |
| R-HSA-72306 | tRNA processing | 0.746607 | 0.127 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.753375 | 0.123 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.753375 | 0.123 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.765446 | 0.116 |
| R-HSA-168255 | Influenza Infection | 0.769306 | 0.114 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.770262 | 0.113 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.773499 | 0.112 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.776690 | 0.110 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.779837 | 0.108 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.779837 | 0.108 |
| R-HSA-3781865 | Diseases of glycosylation | 0.781140 | 0.107 |
| R-HSA-157579 | Telomere Maintenance | 0.782939 | 0.106 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.782939 | 0.106 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.782939 | 0.106 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.785998 | 0.105 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.785998 | 0.105 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.785998 | 0.105 |
| R-HSA-190236 | Signaling by FGFR | 0.785998 | 0.105 |
| R-HSA-422356 | Regulation of insulin secretion | 0.785998 | 0.105 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.791988 | 0.101 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.794919 | 0.100 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.796815 | 0.099 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.797810 | 0.098 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.799953 | 0.097 |
| R-HSA-1266738 | Developmental Biology | 0.803265 | 0.095 |
| R-HSA-109582 | Hemostasis | 0.804331 | 0.095 |
| R-HSA-6798695 | Neutrophil degranulation | 0.805949 | 0.094 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.806241 | 0.094 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.806241 | 0.094 |
| R-HSA-9833110 | RSV-host interactions | 0.806241 | 0.094 |
| R-HSA-9609690 | HCMV Early Events | 0.807398 | 0.093 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.808973 | 0.092 |
| R-HSA-211000 | Gene Silencing by RNA | 0.814322 | 0.089 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.816941 | 0.088 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.816941 | 0.088 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.816941 | 0.088 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.816941 | 0.088 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.819522 | 0.086 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.821392 | 0.085 |
| R-HSA-162582 | Signal Transduction | 0.822875 | 0.085 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.822976 | 0.085 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.827052 | 0.082 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.827052 | 0.082 |
| R-HSA-9824446 | Viral Infection Pathways | 0.828418 | 0.082 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.829491 | 0.081 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.831897 | 0.080 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.836607 | 0.077 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.836607 | 0.077 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.839808 | 0.076 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.841185 | 0.075 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.841185 | 0.075 |
| R-HSA-373760 | L1CAM interactions | 0.841185 | 0.075 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.843426 | 0.074 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.843426 | 0.074 |
| R-HSA-5693538 | Homology Directed Repair | 0.845636 | 0.073 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.847814 | 0.072 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.847814 | 0.072 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.854168 | 0.068 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.854168 | 0.068 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.856227 | 0.067 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.858256 | 0.066 |
| R-HSA-69206 | G1/S Transition | 0.862231 | 0.064 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.863583 | 0.064 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.864176 | 0.063 |
| R-HSA-8956319 | Nucleotide catabolism | 0.869849 | 0.061 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.871688 | 0.060 |
| R-HSA-163685 | Integration of energy metabolism | 0.885492 | 0.053 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.887111 | 0.052 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.888706 | 0.051 |
| R-HSA-1280218 | Adaptive Immune System | 0.891683 | 0.050 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.891830 | 0.050 |
| R-HSA-9664407 | Parasite infection | 0.891830 | 0.050 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.891830 | 0.050 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.893359 | 0.049 |
| R-HSA-9609646 | HCMV Infection | 0.895136 | 0.048 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.897818 | 0.047 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.903476 | 0.044 |
| R-HSA-69242 | S Phase | 0.904841 | 0.043 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.907514 | 0.042 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.910112 | 0.041 |
| R-HSA-9609507 | Protein localization | 0.911383 | 0.040 |
| R-HSA-1989781 | PPARA activates gene expression | 0.913873 | 0.039 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.914630 | 0.039 |
| R-HSA-9610379 | HCMV Late Events | 0.916293 | 0.038 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.916293 | 0.038 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.920338 | 0.036 |
| R-HSA-9658195 | Leishmania infection | 0.926544 | 0.033 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.926544 | 0.033 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.927415 | 0.033 |
| R-HSA-9675108 | Nervous system development | 0.929392 | 0.032 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.932411 | 0.030 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.934312 | 0.030 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.934312 | 0.030 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.935243 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.935480 | 0.029 |
| R-HSA-1643685 | Disease | 0.938919 | 0.027 |
| R-HSA-983712 | Ion channel transport | 0.947724 | 0.023 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.949037 | 0.023 |
| R-HSA-392499 | Metabolism of proteins | 0.952012 | 0.021 |
| R-HSA-5668914 | Diseases of metabolism | 0.952871 | 0.021 |
| R-HSA-72766 | Translation | 0.953859 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.955960 | 0.020 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.956585 | 0.019 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.957201 | 0.019 |
| R-HSA-422475 | Axon guidance | 0.959537 | 0.018 |
| R-HSA-397014 | Muscle contraction | 0.962904 | 0.016 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.965072 | 0.015 |
| R-HSA-9748784 | Drug ADME | 0.965955 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.971328 | 0.013 |
| R-HSA-15869 | Metabolism of nucleotides | 0.973689 | 0.012 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.974063 | 0.011 |
| R-HSA-5663205 | Infectious disease | 0.974095 | 0.011 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.980374 | 0.009 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.982134 | 0.008 |
| R-HSA-416476 | G alpha (q) signalling events | 0.982388 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.984097 | 0.007 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.985595 | 0.006 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.986806 | 0.006 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.987701 | 0.005 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.988878 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.993280 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.994182 | 0.003 |
| R-HSA-168256 | Immune System | 0.994556 | 0.002 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.994665 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 0.994916 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.995825 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.997189 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998711 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999591 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999870 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999898 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999958 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999986 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.781 | 0.474 | 2 | 0.934 |
BMPR1B |
0.755 | 0.472 | 1 | 0.829 |
CK2A2 |
0.754 | 0.445 | 1 | 0.744 |
BMPR1A |
0.753 | 0.508 | 1 | 0.820 |
TGFBR1 |
0.753 | 0.578 | -2 | 0.742 |
ALK2 |
0.748 | 0.598 | -2 | 0.706 |
CK2A1 |
0.742 | 0.397 | 1 | 0.721 |
COT |
0.740 | 0.131 | 2 | 0.616 |
GRK1 |
0.736 | 0.176 | -2 | 0.375 |
ALK4 |
0.734 | 0.518 | -2 | 0.708 |
ACVR2A |
0.734 | 0.406 | -2 | 0.660 |
ACVR2B |
0.733 | 0.395 | -2 | 0.648 |
GRK7 |
0.732 | 0.296 | 1 | 0.742 |
CLK3 |
0.731 | 0.116 | 1 | 0.778 |
DSTYK |
0.730 | 0.203 | 2 | 0.652 |
CAMK2B |
0.729 | 0.220 | 2 | 0.692 |
GRK6 |
0.728 | 0.260 | 1 | 0.812 |
CAMK2G |
0.728 | 0.164 | 2 | 0.645 |
IKKB |
0.728 | 0.077 | -2 | 0.336 |
IKKA |
0.727 | 0.138 | -2 | 0.347 |
TGFBR2 |
0.726 | 0.278 | -2 | 0.676 |
MOS |
0.724 | 0.095 | 1 | 0.872 |
PLK3 |
0.723 | 0.242 | 2 | 0.588 |
CDC7 |
0.722 | 0.048 | 1 | 0.872 |
PLK1 |
0.719 | 0.210 | -2 | 0.499 |
GRK4 |
0.718 | 0.113 | -2 | 0.432 |
PRPK |
0.715 | 0.001 | -1 | 0.747 |
PIM3 |
0.714 | 0.013 | -3 | 0.814 |
BMPR2 |
0.714 | 0.211 | -2 | 0.485 |
GRK5 |
0.714 | 0.085 | -3 | 0.832 |
GCN2 |
0.713 | -0.014 | 2 | 0.532 |
ATM |
0.713 | 0.108 | 1 | 0.689 |
CAMK2A |
0.712 | 0.115 | 2 | 0.643 |
TBK1 |
0.711 | -0.018 | 1 | 0.709 |
RAF1 |
0.711 | -0.077 | 1 | 0.815 |
NEK6 |
0.709 | 0.027 | -2 | 0.476 |
IKKE |
0.709 | -0.026 | 1 | 0.707 |
PLK2 |
0.707 | 0.182 | -3 | 0.807 |
MAPKAPK2 |
0.707 | 0.077 | -3 | 0.716 |
CAMK1B |
0.707 | -0.032 | -3 | 0.838 |
PDHK4 |
0.706 | -0.066 | 1 | 0.809 |
NEK7 |
0.706 | -0.013 | -3 | 0.803 |
NDR2 |
0.705 | -0.042 | -3 | 0.817 |
LATS1 |
0.705 | 0.131 | -3 | 0.831 |
KIS |
0.704 | -0.017 | 1 | 0.610 |
SKMLCK |
0.704 | -0.033 | -2 | 0.357 |
CAMK2D |
0.704 | 0.047 | -3 | 0.811 |
PIM1 |
0.704 | 0.015 | -3 | 0.767 |
GRK2 |
0.703 | 0.068 | -2 | 0.413 |
GRK3 |
0.703 | 0.101 | -2 | 0.419 |
MTOR |
0.703 | -0.100 | 1 | 0.740 |
RSK2 |
0.703 | -0.001 | -3 | 0.752 |
LATS2 |
0.702 | 0.026 | -5 | 0.674 |
ULK2 |
0.702 | -0.111 | 2 | 0.521 |
CLK2 |
0.702 | 0.064 | -3 | 0.741 |
PKN3 |
0.701 | -0.032 | -3 | 0.800 |
MLK1 |
0.700 | -0.089 | 2 | 0.541 |
HUNK |
0.699 | -0.081 | 2 | 0.538 |
ATR |
0.699 | -0.031 | 1 | 0.742 |
TLK2 |
0.699 | 0.163 | 1 | 0.720 |
AURA |
0.698 | -0.017 | -2 | 0.283 |
PDHK1 |
0.697 | -0.127 | 1 | 0.793 |
CAMLCK |
0.697 | -0.071 | -2 | 0.371 |
ULK1 |
0.697 | -0.074 | -3 | 0.779 |
MARK4 |
0.696 | -0.069 | 4 | 0.764 |
CDKL1 |
0.695 | -0.056 | -3 | 0.768 |
PRKD1 |
0.694 | -0.063 | -3 | 0.790 |
ERK5 |
0.694 | -0.091 | 1 | 0.746 |
NIK |
0.693 | -0.138 | -3 | 0.857 |
TLK1 |
0.693 | 0.168 | -2 | 0.565 |
PRKX |
0.693 | 0.002 | -3 | 0.675 |
TSSK2 |
0.692 | -0.057 | -5 | 0.730 |
RSK4 |
0.692 | 0.008 | -3 | 0.723 |
SRPK1 |
0.692 | -0.025 | -3 | 0.720 |
MLK4 |
0.692 | -0.034 | 2 | 0.477 |
RIPK3 |
0.692 | -0.197 | 3 | 0.286 |
CHAK2 |
0.692 | -0.127 | -1 | 0.717 |
TTBK2 |
0.691 | -0.057 | 2 | 0.448 |
BCKDK |
0.691 | -0.089 | -1 | 0.678 |
NLK |
0.691 | -0.144 | 1 | 0.751 |
P90RSK |
0.691 | -0.044 | -3 | 0.748 |
DNAPK |
0.691 | 0.058 | 1 | 0.624 |
ANKRD3 |
0.691 | -0.101 | 1 | 0.794 |
NDR1 |
0.691 | -0.110 | -3 | 0.814 |
DLK |
0.691 | -0.086 | 1 | 0.777 |
DAPK2 |
0.691 | -0.100 | -3 | 0.838 |
MLK3 |
0.690 | -0.081 | 2 | 0.483 |
MAPKAPK3 |
0.690 | -0.036 | -3 | 0.755 |
P70S6KB |
0.689 | -0.060 | -3 | 0.776 |
PKACG |
0.689 | -0.077 | -2 | 0.305 |
MST4 |
0.688 | -0.132 | 2 | 0.561 |
SRPK2 |
0.688 | -0.007 | -3 | 0.650 |
MASTL |
0.688 | -0.198 | -2 | 0.356 |
MSK2 |
0.688 | -0.040 | -3 | 0.709 |
PRKD2 |
0.688 | -0.068 | -3 | 0.756 |
MSK1 |
0.688 | -0.019 | -3 | 0.717 |
AURC |
0.688 | -0.074 | -2 | 0.281 |
PKCD |
0.688 | -0.099 | 2 | 0.518 |
NUAK2 |
0.687 | -0.113 | -3 | 0.825 |
PKACB |
0.687 | -0.032 | -2 | 0.285 |
CLK4 |
0.687 | -0.001 | -3 | 0.751 |
WNK1 |
0.687 | -0.160 | -2 | 0.335 |
AMPKA1 |
0.687 | -0.097 | -3 | 0.833 |
RSK3 |
0.686 | -0.067 | -3 | 0.745 |
PAK1 |
0.686 | -0.077 | -2 | 0.310 |
BRAF |
0.685 | 0.022 | -4 | 0.838 |
SRPK3 |
0.685 | -0.019 | -3 | 0.691 |
CDKL5 |
0.684 | -0.078 | -3 | 0.758 |
MEK1 |
0.684 | -0.090 | 2 | 0.575 |
PERK |
0.684 | 0.046 | -2 | 0.538 |
IRE2 |
0.684 | -0.097 | 2 | 0.489 |
PKN2 |
0.683 | -0.141 | -3 | 0.813 |
ICK |
0.683 | -0.087 | -3 | 0.803 |
YSK4 |
0.683 | -0.093 | 1 | 0.744 |
WNK3 |
0.683 | -0.236 | 1 | 0.763 |
NEK9 |
0.682 | -0.183 | 2 | 0.539 |
CAMK4 |
0.682 | -0.113 | -3 | 0.805 |
BRSK1 |
0.681 | -0.059 | -3 | 0.774 |
AURB |
0.681 | -0.080 | -2 | 0.281 |
TSSK1 |
0.681 | -0.099 | -3 | 0.853 |
PLK4 |
0.681 | -0.068 | 2 | 0.412 |
DRAK1 |
0.681 | -0.058 | 1 | 0.734 |
MYLK4 |
0.681 | -0.073 | -2 | 0.316 |
NIM1 |
0.681 | -0.165 | 3 | 0.309 |
CHK1 |
0.680 | -0.020 | -3 | 0.817 |
HIPK4 |
0.680 | -0.107 | 1 | 0.711 |
PKR |
0.680 | -0.103 | 1 | 0.790 |
MARK2 |
0.680 | -0.057 | 4 | 0.663 |
CDK8 |
0.680 | -0.059 | 1 | 0.576 |
CDK1 |
0.679 | -0.037 | 1 | 0.552 |
MARK3 |
0.679 | -0.066 | 4 | 0.697 |
MEKK3 |
0.679 | -0.085 | 1 | 0.753 |
AMPKA2 |
0.679 | -0.101 | -3 | 0.803 |
MLK2 |
0.679 | -0.211 | 2 | 0.537 |
JNK3 |
0.678 | -0.011 | 1 | 0.576 |
CLK1 |
0.678 | -0.020 | -3 | 0.733 |
PAK6 |
0.678 | -0.071 | -2 | 0.271 |
PAK2 |
0.677 | -0.109 | -2 | 0.307 |
HRI |
0.677 | -0.021 | -2 | 0.515 |
QSK |
0.677 | -0.104 | 4 | 0.735 |
PAK3 |
0.676 | -0.138 | -2 | 0.306 |
RIPK1 |
0.676 | -0.242 | 1 | 0.764 |
PASK |
0.676 | -0.004 | -3 | 0.820 |
CK1E |
0.676 | -0.022 | -3 | 0.555 |
MARK1 |
0.676 | -0.074 | 4 | 0.719 |
PKACA |
0.675 | -0.040 | -2 | 0.266 |
GSK3A |
0.674 | 0.021 | 4 | 0.429 |
DCAMKL1 |
0.674 | -0.026 | -3 | 0.780 |
IRE1 |
0.674 | -0.189 | 1 | 0.746 |
PKG2 |
0.673 | -0.092 | -2 | 0.276 |
DYRK2 |
0.673 | -0.060 | 1 | 0.615 |
JNK2 |
0.673 | -0.022 | 1 | 0.537 |
MNK2 |
0.673 | -0.123 | -2 | 0.322 |
PKCB |
0.673 | -0.119 | 2 | 0.469 |
PHKG1 |
0.673 | -0.100 | -3 | 0.808 |
PKCG |
0.672 | -0.130 | 2 | 0.470 |
NUAK1 |
0.672 | -0.123 | -3 | 0.778 |
PIM2 |
0.672 | -0.052 | -3 | 0.727 |
CDK5 |
0.671 | -0.068 | 1 | 0.609 |
VRK2 |
0.671 | -0.294 | 1 | 0.804 |
SIK |
0.671 | -0.109 | -3 | 0.746 |
CK1D |
0.671 | -0.004 | -3 | 0.502 |
DCAMKL2 |
0.671 | -0.033 | -3 | 0.802 |
PRKD3 |
0.670 | -0.094 | -3 | 0.723 |
QIK |
0.670 | -0.185 | -3 | 0.807 |
NEK2 |
0.670 | -0.159 | 2 | 0.513 |
MEKK2 |
0.670 | -0.132 | 2 | 0.526 |
SMG1 |
0.670 | -0.084 | 1 | 0.688 |
MELK |
0.670 | -0.155 | -3 | 0.787 |
PKCA |
0.670 | -0.129 | 2 | 0.466 |
PINK1 |
0.669 | -0.114 | 1 | 0.755 |
MNK1 |
0.669 | -0.118 | -2 | 0.331 |
CDK3 |
0.669 | -0.037 | 1 | 0.492 |
PKCH |
0.669 | -0.135 | 2 | 0.462 |
CAMK1D |
0.669 | -0.019 | -3 | 0.682 |
CDK2 |
0.668 | -0.086 | 1 | 0.624 |
BRSK2 |
0.668 | -0.120 | -3 | 0.798 |
CAMK1G |
0.668 | -0.092 | -3 | 0.742 |
CDK19 |
0.668 | -0.077 | 1 | 0.538 |
SGK3 |
0.668 | -0.081 | -3 | 0.739 |
SNRK |
0.668 | -0.197 | 2 | 0.446 |
ZAK |
0.667 | -0.141 | 1 | 0.725 |
MAPKAPK5 |
0.667 | -0.094 | -3 | 0.688 |
PRP4 |
0.667 | -0.047 | -3 | 0.728 |
P38B |
0.667 | -0.044 | 1 | 0.556 |
CHAK1 |
0.667 | -0.218 | 2 | 0.481 |
P38A |
0.667 | -0.074 | 1 | 0.626 |
DYRK4 |
0.666 | -0.031 | 1 | 0.544 |
TTBK1 |
0.666 | -0.085 | 2 | 0.398 |
AKT2 |
0.666 | -0.069 | -3 | 0.673 |
PKCZ |
0.666 | -0.167 | 2 | 0.496 |
EEF2K |
0.666 | -0.004 | 3 | 0.322 |
TAO3 |
0.665 | -0.112 | 1 | 0.749 |
SSTK |
0.665 | -0.098 | 4 | 0.715 |
NEK5 |
0.665 | -0.140 | 1 | 0.771 |
GSK3B |
0.665 | -0.024 | 4 | 0.414 |
MEKK1 |
0.665 | -0.175 | 1 | 0.744 |
P38G |
0.665 | -0.031 | 1 | 0.465 |
GAK |
0.665 | -0.027 | 1 | 0.803 |
CDK13 |
0.664 | -0.085 | 1 | 0.570 |
MEK5 |
0.664 | -0.245 | 2 | 0.547 |
CAMKK1 |
0.664 | -0.119 | -2 | 0.313 |
CK1A2 |
0.663 | -0.027 | -3 | 0.504 |
SMMLCK |
0.663 | -0.100 | -3 | 0.788 |
JNK1 |
0.663 | -0.019 | 1 | 0.528 |
DAPK3 |
0.663 | -0.051 | -3 | 0.784 |
ERK1 |
0.663 | -0.071 | 1 | 0.548 |
NEK8 |
0.662 | -0.130 | 2 | 0.528 |
CDK7 |
0.661 | -0.104 | 1 | 0.594 |
MST2 |
0.661 | -0.054 | 1 | 0.765 |
CK1G1 |
0.661 | -0.054 | -3 | 0.549 |
PAK4 |
0.661 | -0.087 | -2 | 0.266 |
ERK2 |
0.661 | -0.088 | 1 | 0.595 |
TTK |
0.661 | 0.072 | -2 | 0.539 |
HIPK2 |
0.661 | -0.063 | 1 | 0.534 |
P38D |
0.660 | -0.033 | 1 | 0.481 |
PAK5 |
0.659 | -0.095 | -2 | 0.257 |
DAPK1 |
0.659 | -0.049 | -3 | 0.759 |
DYRK1B |
0.657 | -0.058 | 1 | 0.578 |
MST3 |
0.657 | -0.180 | 2 | 0.528 |
AKT1 |
0.657 | -0.081 | -3 | 0.693 |
HIPK1 |
0.657 | -0.086 | 1 | 0.635 |
WNK4 |
0.657 | -0.210 | -2 | 0.336 |
CAMKK2 |
0.657 | -0.130 | -2 | 0.310 |
P70S6K |
0.656 | -0.093 | -3 | 0.682 |
DYRK1A |
0.656 | -0.083 | 1 | 0.657 |
ALPHAK3 |
0.656 | 0.076 | -1 | 0.719 |
CDK18 |
0.656 | -0.088 | 1 | 0.525 |
TAK1 |
0.656 | -0.090 | 1 | 0.775 |
IRAK1 |
0.656 | -0.205 | -1 | 0.628 |
PDHK3_TYR |
0.656 | 0.146 | 4 | 0.847 |
CDK12 |
0.655 | -0.088 | 1 | 0.542 |
TAO2 |
0.655 | -0.161 | 2 | 0.565 |
MAP2K6_TYR |
0.655 | 0.202 | -1 | 0.779 |
ERK7 |
0.654 | -0.064 | 2 | 0.355 |
PKCT |
0.654 | -0.155 | 2 | 0.465 |
PHKG2 |
0.654 | -0.143 | -3 | 0.787 |
PDHK1_TYR |
0.654 | 0.189 | -1 | 0.816 |
IRAK4 |
0.654 | -0.242 | 1 | 0.755 |
CDK17 |
0.654 | -0.079 | 1 | 0.471 |
PDHK4_TYR |
0.653 | 0.149 | 2 | 0.629 |
CDK9 |
0.652 | -0.107 | 1 | 0.579 |
GCK |
0.652 | -0.127 | 1 | 0.760 |
PDK1 |
0.652 | -0.135 | 1 | 0.760 |
DYRK3 |
0.651 | -0.077 | 1 | 0.636 |
SGK1 |
0.649 | -0.041 | -3 | 0.592 |
TNIK |
0.649 | -0.128 | 3 | 0.299 |
MST1 |
0.649 | -0.098 | 1 | 0.748 |
MPSK1 |
0.649 | -0.148 | 1 | 0.737 |
PKCI |
0.648 | -0.162 | 2 | 0.471 |
NEK11 |
0.648 | -0.235 | 1 | 0.743 |
MAP2K4_TYR |
0.647 | 0.086 | -1 | 0.767 |
CDK16 |
0.647 | -0.075 | 1 | 0.490 |
MINK |
0.647 | -0.158 | 1 | 0.756 |
PKCE |
0.647 | -0.120 | 2 | 0.458 |
LKB1 |
0.647 | -0.181 | -3 | 0.799 |
BMPR2_TYR |
0.647 | 0.068 | -1 | 0.782 |
SLK |
0.646 | -0.131 | -2 | 0.310 |
HIPK3 |
0.646 | -0.127 | 1 | 0.634 |
YANK3 |
0.646 | -0.050 | 2 | 0.282 |
EPHA4 |
0.646 | 0.093 | 2 | 0.598 |
INSRR |
0.645 | 0.067 | 3 | 0.285 |
EPHA6 |
0.645 | 0.041 | -1 | 0.802 |
OSR1 |
0.645 | -0.060 | 2 | 0.508 |
HGK |
0.645 | -0.173 | 3 | 0.293 |
CAMK1A |
0.645 | -0.071 | -3 | 0.642 |
RIPK2 |
0.644 | -0.206 | 1 | 0.696 |
AKT3 |
0.644 | -0.074 | -3 | 0.608 |
CDK14 |
0.644 | -0.111 | 1 | 0.567 |
NEK4 |
0.644 | -0.229 | 1 | 0.745 |
STK33 |
0.643 | -0.157 | 2 | 0.402 |
BLK |
0.643 | 0.083 | -1 | 0.768 |
SBK |
0.643 | -0.023 | -3 | 0.564 |
HPK1 |
0.643 | -0.156 | 1 | 0.753 |
TXK |
0.642 | 0.076 | 1 | 0.809 |
CHK2 |
0.642 | -0.073 | -3 | 0.626 |
MRCKB |
0.642 | -0.087 | -3 | 0.719 |
MRCKA |
0.642 | -0.089 | -3 | 0.741 |
VRK1 |
0.642 | -0.232 | 2 | 0.554 |
FYN |
0.642 | 0.095 | -1 | 0.723 |
MAP2K7_TYR |
0.642 | -0.024 | 2 | 0.603 |
ROCK2 |
0.642 | -0.091 | -3 | 0.768 |
MEK2 |
0.642 | -0.184 | 2 | 0.534 |
YES1 |
0.641 | 0.031 | -1 | 0.734 |
LRRK2 |
0.641 | -0.233 | 2 | 0.559 |
CK1A |
0.641 | -0.017 | -3 | 0.418 |
FER |
0.641 | 0.064 | 1 | 0.832 |
SRMS |
0.641 | 0.087 | 1 | 0.825 |
NEK1 |
0.641 | -0.204 | 1 | 0.753 |
MAK |
0.641 | -0.060 | -2 | 0.283 |
EPHB2 |
0.641 | 0.072 | -1 | 0.776 |
EPHB4 |
0.640 | -0.005 | -1 | 0.780 |
PKN1 |
0.640 | -0.121 | -3 | 0.705 |
TESK1_TYR |
0.639 | -0.095 | 3 | 0.360 |
KHS2 |
0.638 | -0.122 | 1 | 0.753 |
MAP3K15 |
0.638 | -0.236 | 1 | 0.715 |
PINK1_TYR |
0.638 | -0.079 | 1 | 0.794 |
LOK |
0.637 | -0.201 | -2 | 0.313 |
KHS1 |
0.637 | -0.150 | 1 | 0.747 |
CDK10 |
0.637 | -0.103 | 1 | 0.553 |
PKG1 |
0.637 | -0.108 | -2 | 0.250 |
CK1G2 |
0.637 | 0.030 | -3 | 0.466 |
EPHA5 |
0.636 | 0.091 | 2 | 0.604 |
LCK |
0.636 | 0.024 | -1 | 0.750 |
DMPK1 |
0.636 | -0.071 | -3 | 0.753 |
ABL2 |
0.636 | -0.006 | -1 | 0.734 |
HCK |
0.635 | 0.004 | -1 | 0.738 |
CDK6 |
0.635 | -0.102 | 1 | 0.548 |
EPHB3 |
0.635 | 0.022 | -1 | 0.771 |
EPHB1 |
0.634 | 0.004 | 1 | 0.811 |
SYK |
0.633 | 0.117 | -1 | 0.756 |
BUB1 |
0.633 | -0.115 | -5 | 0.701 |
FGR |
0.633 | -0.011 | 1 | 0.794 |
PKMYT1_TYR |
0.632 | -0.170 | 3 | 0.341 |
MEKK6 |
0.632 | -0.290 | 1 | 0.739 |
FGFR2 |
0.632 | 0.008 | 3 | 0.314 |
EPHA7 |
0.632 | 0.026 | 2 | 0.586 |
CDK4 |
0.632 | -0.099 | 1 | 0.526 |
BIKE |
0.631 | -0.025 | 1 | 0.691 |
YSK1 |
0.631 | -0.208 | 2 | 0.510 |
RET |
0.631 | -0.093 | 1 | 0.746 |
LYN |
0.630 | 0.022 | 3 | 0.271 |
CSF1R |
0.630 | -0.085 | 3 | 0.281 |
EGFR |
0.630 | 0.085 | 1 | 0.621 |
EPHA8 |
0.629 | 0.050 | -1 | 0.779 |
MOK |
0.629 | -0.087 | 1 | 0.658 |
FGFR3 |
0.629 | 0.017 | 3 | 0.306 |
PBK |
0.629 | -0.111 | 1 | 0.732 |
ITK |
0.628 | -0.032 | -1 | 0.703 |
KIT |
0.628 | -0.034 | 3 | 0.286 |
FLT1 |
0.628 | 0.019 | -1 | 0.804 |
MERTK |
0.628 | -0.039 | 3 | 0.298 |
JAK3 |
0.628 | -0.069 | 1 | 0.735 |
ROCK1 |
0.627 | -0.101 | -3 | 0.737 |
ABL1 |
0.627 | -0.061 | -1 | 0.718 |
PTK2 |
0.627 | 0.053 | -1 | 0.720 |
ROS1 |
0.627 | -0.148 | 3 | 0.266 |
SRC |
0.627 | 0.027 | -1 | 0.720 |
TYRO3 |
0.626 | -0.156 | 3 | 0.279 |
FGFR4 |
0.626 | 0.053 | -1 | 0.735 |
TEC |
0.626 | -0.010 | -1 | 0.641 |
ASK1 |
0.626 | -0.174 | 1 | 0.708 |
TYK2 |
0.626 | -0.158 | 1 | 0.749 |
EPHA3 |
0.625 | -0.029 | 2 | 0.566 |
CK1G3 |
0.625 | -0.006 | -3 | 0.371 |
BMX |
0.625 | -0.017 | -1 | 0.646 |
JAK2 |
0.625 | -0.143 | 1 | 0.740 |
CRIK |
0.625 | -0.073 | -3 | 0.685 |
HASPIN |
0.625 | -0.102 | -1 | 0.556 |
DDR1 |
0.625 | -0.108 | 4 | 0.751 |
EPHA2 |
0.624 | 0.054 | -1 | 0.748 |
ERBB2 |
0.624 | -0.014 | 1 | 0.713 |
STLK3 |
0.624 | -0.106 | 1 | 0.695 |
MYO3A |
0.623 | -0.177 | 1 | 0.738 |
LIMK2_TYR |
0.623 | -0.193 | -3 | 0.861 |
NTRK1 |
0.623 | -0.030 | -1 | 0.724 |
MST1R |
0.622 | -0.200 | 3 | 0.293 |
IGF1R |
0.622 | 0.012 | 3 | 0.260 |
NEK3 |
0.622 | -0.235 | 1 | 0.709 |
FRK |
0.622 | -0.011 | -1 | 0.783 |
KDR |
0.622 | -0.101 | 3 | 0.274 |
FLT3 |
0.622 | -0.094 | 3 | 0.273 |
TEK |
0.621 | -0.087 | 3 | 0.268 |
ERBB4 |
0.621 | 0.045 | 1 | 0.647 |
INSR |
0.621 | -0.050 | 3 | 0.271 |
FGFR1 |
0.621 | -0.078 | 3 | 0.297 |
MET |
0.620 | -0.067 | 3 | 0.280 |
LTK |
0.620 | -0.087 | 3 | 0.277 |
LIMK1_TYR |
0.620 | -0.233 | 2 | 0.585 |
MYO3B |
0.619 | -0.195 | 2 | 0.525 |
YANK2 |
0.619 | -0.057 | 2 | 0.311 |
PDGFRB |
0.619 | -0.131 | 3 | 0.283 |
TAO1 |
0.619 | -0.183 | 1 | 0.687 |
ALK |
0.619 | -0.106 | 3 | 0.259 |
FLT4 |
0.618 | -0.060 | 3 | 0.292 |
PTK2B |
0.618 | -0.028 | -1 | 0.671 |
AXL |
0.617 | -0.128 | 3 | 0.291 |
NTRK3 |
0.617 | -0.030 | -1 | 0.695 |
TNK2 |
0.617 | -0.146 | 3 | 0.274 |
CSK |
0.616 | -0.035 | 2 | 0.571 |
BTK |
0.616 | -0.101 | -1 | 0.652 |
PTK6 |
0.615 | -0.079 | -1 | 0.637 |
NTRK2 |
0.614 | -0.104 | 3 | 0.283 |
MATK |
0.613 | -0.040 | -1 | 0.695 |
NEK10_TYR |
0.613 | -0.107 | 1 | 0.665 |
AAK1 |
0.611 | -0.012 | 1 | 0.595 |
EPHA1 |
0.611 | -0.114 | 3 | 0.267 |
DDR2 |
0.611 | -0.081 | 3 | 0.279 |
JAK1 |
0.609 | -0.162 | 1 | 0.698 |
TNK1 |
0.606 | -0.217 | 3 | 0.279 |
WEE1_TYR |
0.605 | -0.142 | -1 | 0.648 |
PDGFRA |
0.604 | -0.224 | 3 | 0.276 |
TNNI3K_TYR |
0.602 | -0.160 | 1 | 0.736 |
ZAP70 |
0.597 | -0.010 | -1 | 0.653 |
FES |
0.595 | -0.073 | -1 | 0.621 |
MUSK |
0.593 | -0.094 | 1 | 0.619 |