Motif 556 (n=141)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S752 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| B5ME19 | EIF3CL | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| M0QZ92 | None | S40 | ochoa | SEC7 domain-containing protein | None |
| O00541 | PES1 | S307 | ochoa | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| O15078 | CEP290 | S2369 | ochoa | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}. |
| O43609 | SPRY1 | S169 | ochoa | Protein sprouty homolog 1 (Spry-1) | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}. |
| O43707 | ACTN4 | S159 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60231 | DHX16 | S106 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| O60701 | UGDH | S476 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60841 | EIF5B | S190 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60841 | EIF5B | S435 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75533 | SF3B1 | S488 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75554 | WBP4 | S323 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O75665 | OFD1 | S943 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O94874 | UFL1 | S429 | ochoa | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:27351204, PubMed:30626644, PubMed:30783677, PubMed:32160526, PubMed:32807901, PubMed:35394863, PubMed:36121123, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37311461, PubMed:37595036, PubMed:37795761, PubMed:38377992, PubMed:38383785, PubMed:38383789). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (PubMed:20018847, PubMed:20531390, PubMed:25219498, PubMed:30783677, PubMed:30886146, PubMed:32160526, PubMed:35753586, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37036982, PubMed:37595036, PubMed:38383785, PubMed:38383789). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:23152784, PubMed:32160526, PubMed:36543799). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (PubMed:20018847, PubMed:20531390). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (PubMed:38377992). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (PubMed:30783677, PubMed:30886146). Mediates ufmylation of TP53/p53, promoting its stability (PubMed:32807901). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CCJ3, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:20531390, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:27351204, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:30783677, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:32050156, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:32807901, ECO:0000269|PubMed:35394863, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:36893266, ECO:0000269|PubMed:37036982, ECO:0000269|PubMed:37311461, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38377992, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| O94885 | SASH1 | S135 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94988 | FAM13A | S555 | ochoa | Protein FAM13A | None |
| O95810 | CAVIN2 | S226 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P05814 | CSN2 | S23 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P07550 | ADRB2 | S246 | ochoa|psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07942 | LAMB1 | S1682 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P08238 | HSP90AB1 | S490 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09429 | HMGB1 | S42 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P09488 | GSTM1 | S27 | ochoa | Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16548513, ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:9084911}. |
| P10451 | SPP1 | S275 | ochoa | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11137 | MAP2 | S1134 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11171 | EPB41 | S674 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11388 | TOP2A | S1247 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12814 | ACTN1 | S140 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | S1041 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1037 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1039 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1040 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P18827 | SDC1 | S287 | ochoa | Syndecan-1 (SYND1) (CD antigen CD138) | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}. |
| P21728 | DRD1 | S254 | psp | D(1A) dopamine receptor (Dopamine D1 receptor) | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| P23497 | SP100 | S409 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P25685 | DNAJB1 | S171 | ochoa|psp | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P27816 | MAP4 | S941 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28161 | GSTM2 | S27 | ochoa | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276}. |
| P35609 | ACTN2 | S147 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35659 | DEK | S251 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P40926 | MDH2 | S309 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41236 | PPP1R2 | S122 | ochoa|psp | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P46100 | ATRX | S930 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S561 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46940 | IQGAP1 | S1441 | ochoa|psp | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49792 | RANBP2 | S1647 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P78380 | OLR1 | S95 | ochoa | Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form] | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. {ECO:0000269|PubMed:11821063, ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. {ECO:0000305|PubMed:27302108}. |
| P78527 | PRKDC | S503 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P98175 | RBM10 | S622 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00059 | TFAM | S124 | ochoa | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q01831 | XPC | S346 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02790 | FKBP4 | S217 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02952 | AKAP12 | S1259 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03013 | GSTM4 | S27 | ochoa | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}. |
| Q03468 | ERCC6 | S489 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q05D32 | CTDSPL2 | S36 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q08043 | ACTN3 | S154 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08431 | MFGE8 | S42 | ochoa | Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. {ECO:0000250, ECO:0000269|PubMed:19204935}.; FUNCTION: [Medin]: Main constituent of aortic medial amyloid. {ECO:0000269|PubMed:19204935}. |
| Q0VF96 | CGNL1 | S476 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q13277 | STX3 | S109 | ochoa | Syntaxin-3 | Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}. |
| Q13557 | CAMK2D | S330 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13576 | IQGAP2 | S1356 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q13601 | KRR1 | S238 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13772 | NCOA4 | S507 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q13813 | SPTAN1 | S1075 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14162 | SCARF1 | S680 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14203 | DCTN1 | S541 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14680 | MELK | S505 | ochoa|psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14692 | BMS1 | Y651 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q15054 | POLD3 | S269 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15061 | WDR43 | S437 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15424 | SAFB | S209 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15910 | EZH2 | S474 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q16533 | SNAPC1 | S292 | ochoa | snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q27J81 | INF2 | S1229 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q49A26 | GLYR1 | S223 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q4G0J3 | LARP7 | S337 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q562F6 | SGO2 | S1181 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JSZ5 | PRRC2B | S168 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T0N5 | FNBP1L | S302 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5VT52 | RPRD2 | S374 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q659C4 | LARP1B | S60 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q6NXS1 | PPP1R2B | S122 | ochoa|psp | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6NYC1 | JMJD6 | S136 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6P1J9 | CDC73 | S178 | ochoa | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6P6C2 | ALKBH5 | S69 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6UWE0 | LRSAM1 | S243 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q70Z53 | FRA10AC1 | S283 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q71F23 | CENPU | S141 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q76FK4 | NOL8 | S707 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L014 | DDX46 | S346 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
| Q86UE4 | MTDH | S415 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86VG3 | IFTAP | S193 | ochoa | Intraflagellar transport-associated protein (Protein HEPIS) | Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. {ECO:0000269|PubMed:30476139}. |
| Q8IV48 | ERI1 | S34 | ochoa | 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}. |
| Q8IWS0 | PHF6 | S145 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8N344 | MIER2 | S177 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8NCP5 | ZBTB44 | S168 | ochoa | Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q8NFC6 | BOD1L1 | S1703 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TBZ6 | TRMT10A | S28 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
| Q8WVM8 | SCFD1 | S297 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WXX7 | AUTS2 | S149 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q8WYP5 | AHCTF1 | S1827 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92541 | RTF1 | S58 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92766 | RREB1 | S1479 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q96HI0 | SENP5 | S176 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96L73 | NSD1 | S486 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96SB4 | SRPK1 | S587 | psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99418 | CYTH2 | S56 | ochoa | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
| Q99459 | CDC5L | S253 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99496 | RNF2 | S143 | ochoa | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:21772249, PubMed:25355358, PubMed:25519132, PubMed:26151332, PubMed:33864376). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q9CQJ4, ECO:0000269|PubMed:11513855, ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:20696397, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:33864376, ECO:0000305}. |
| Q99613 | EIF3C | S181 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99986 | VRK1 | S342 | ochoa|psp | Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) | Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (PubMed:14645249, PubMed:18617507, PubMed:19103756, PubMed:33076429). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (PubMed:31527692, PubMed:37179361). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (PubMed:21920476, PubMed:31090908, PubMed:31527692). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (PubMed:19103756). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336). Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425). Phosphorylates JUN (PubMed:31527692). {ECO:0000250|UniProtKB:Q80X41, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:21920476, ECO:0000269|PubMed:31090908, ECO:0000269|PubMed:31527692, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:37179361}. |
| Q9BQ39 | DDX50 | S45 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BW30 | TPPP3 | S158 | ochoa | Tubulin polymerization-promoting protein family member 3 (TPPP/p20) | Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (PubMed:30667362). {ECO:0000250|UniProtKB:Q9CRB6, ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818, ECO:0000269|PubMed:30667362}. |
| Q9BXY4 | RSPO3 | S241 | ochoa | R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}. |
| Q9BYT3 | STK33 | S43 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9C0B9 | ZCCHC2 | S493 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9H0G5 | NSRP1 | S446 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9NQW6 | ANLN | S344 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NVI1 | FANCI | T1310 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9UKJ3 | GPATCH8 | S469 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKV3 | ACIN1 | S898 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1043 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULG1 | INO80 | S236 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9ULH0 | KIDINS220 | S1526 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9UM21 | MGAT4A | S474 | ochoa | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form] | Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:Q812G0, ECO:0000269|PubMed:17006639}. |
| Q9UQM7 | CAMK2A | S330 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2J2 | EPB41L3 | S88 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3E1 | HDGFL3 | S121 | ochoa | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}. |
| Q9Y3T9 | NOC2L | S635 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y623 | MYH4 | S1041 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6J0 | CABIN1 | S386 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P61604 | HSPE1 | S21 | Sugiyama | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
| Q9UGY1 | NOL12 | S21 | Sugiyama | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q14192 | FHL2 | S238 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| P55036 | PSMD4 | S115 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| Q9BZC7 | ABCA2 | S1113 | Sugiyama | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9Y5K3 | PCYT1B | S260 | GPS6 | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| P31949 | S100A11 | S35 | Sugiyama | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| Q8IY84 | NIM1K | S82 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-373753 | Nephrin family interactions | 2.697579e-07 | 6.569 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.865004e-06 | 5.543 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.811316e-04 | 3.742 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.811316e-04 | 3.742 |
| R-HSA-3371568 | Attenuation phase | 1.302137e-04 | 3.885 |
| R-HSA-3371556 | Cellular response to heat stress | 8.016628e-05 | 4.096 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.811316e-04 | 3.742 |
| R-HSA-9620244 | Long-term potentiation | 3.050548e-04 | 3.516 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 3.384835e-04 | 3.470 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.178313e-04 | 3.144 |
| R-HSA-390522 | Striated Muscle Contraction | 7.881570e-04 | 3.103 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.632130e-04 | 3.064 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.592041e-03 | 2.798 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.654562e-03 | 2.781 |
| R-HSA-72172 | mRNA Splicing | 2.171078e-03 | 2.663 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.640119e-03 | 2.439 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 3.884936e-03 | 2.411 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 4.764594e-03 | 2.322 |
| R-HSA-156590 | Glutathione conjugation | 5.295236e-03 | 2.276 |
| R-HSA-68877 | Mitotic Prometaphase | 6.162631e-03 | 2.210 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.089461e-03 | 2.149 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.082992e-03 | 2.092 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.767024e-03 | 2.110 |
| R-HSA-3371511 | HSF1 activation | 9.823732e-03 | 2.008 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.246182e-03 | 2.034 |
| R-HSA-111933 | Calmodulin induced events | 9.823732e-03 | 2.008 |
| R-HSA-111997 | CaM pathway | 9.823732e-03 | 2.008 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.305892e-02 | 1.884 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.582581e-02 | 1.801 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.582581e-02 | 1.801 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.474586e-02 | 1.831 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.391426e-02 | 1.857 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.795825e-02 | 1.746 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.795825e-02 | 1.746 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.795825e-02 | 1.746 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.795825e-02 | 1.746 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.695429e-02 | 1.771 |
| R-HSA-8953854 | Metabolism of RNA | 1.367444e-02 | 1.864 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.685047e-02 | 1.773 |
| R-HSA-111996 | Ca-dependent events | 1.467644e-02 | 1.833 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.710271e-02 | 1.767 |
| R-HSA-75153 | Apoptotic execution phase | 1.795825e-02 | 1.746 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.004236e-02 | 1.698 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.004236e-02 | 1.698 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.004236e-02 | 1.698 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.004236e-02 | 1.698 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.004236e-02 | 1.698 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.948187e-02 | 1.710 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.460570e-02 | 1.609 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.358540e-02 | 1.627 |
| R-HSA-449836 | Other interleukin signaling | 2.503062e-02 | 1.602 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.551102e-02 | 1.593 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.702027e-02 | 1.568 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.858198e-02 | 1.544 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.858198e-02 | 1.544 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.698307e-02 | 1.569 |
| R-HSA-163282 | Mitochondrial transcription initiation | 2.991331e-02 | 1.524 |
| R-HSA-397014 | Muscle contraction | 3.156223e-02 | 1.501 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.609771e-02 | 1.443 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.609771e-02 | 1.443 |
| R-HSA-3000170 | Syndecan interactions | 3.537362e-02 | 1.451 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.535837e-02 | 1.452 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.446473e-02 | 1.463 |
| R-HSA-1640170 | Cell Cycle | 3.483303e-02 | 1.458 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.609771e-02 | 1.443 |
| R-HSA-2262752 | Cellular responses to stress | 3.493730e-02 | 1.457 |
| R-HSA-112043 | PLC beta mediated events | 3.361297e-02 | 1.473 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.867450e-02 | 1.413 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 3.968544e-02 | 1.401 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.999720e-02 | 1.398 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.694964e-02 | 1.328 |
| R-HSA-72312 | rRNA processing | 4.414961e-02 | 1.355 |
| R-HSA-73894 | DNA Repair | 4.053840e-02 | 1.392 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.462948e-02 | 1.350 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.100119e-02 | 1.387 |
| R-HSA-112040 | G-protein mediated events | 4.134263e-02 | 1.384 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.706904e-02 | 1.327 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.988667e-02 | 1.302 |
| R-HSA-380287 | Centrosome maturation | 5.291136e-02 | 1.276 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.291136e-02 | 1.276 |
| R-HSA-6798695 | Neutrophil degranulation | 5.525935e-02 | 1.258 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.291136e-02 | 1.276 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.927516e-02 | 1.307 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.466962e-02 | 1.262 |
| R-HSA-68886 | M Phase | 5.366786e-02 | 1.270 |
| R-HSA-8852135 | Protein ubiquitination | 5.291136e-02 | 1.276 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.896358e-02 | 1.310 |
| R-HSA-1538133 | G0 and Early G1 | 5.729319e-02 | 1.242 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.729319e-02 | 1.242 |
| R-HSA-1500931 | Cell-Cell communication | 5.597182e-02 | 1.252 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.761037e-02 | 1.239 |
| R-HSA-390651 | Dopamine receptors | 5.893714e-02 | 1.230 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.995986e-02 | 1.222 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.995986e-02 | 1.222 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.995986e-02 | 1.222 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.109359e-02 | 1.214 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.643963e-02 | 1.117 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.930943e-02 | 1.159 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.757660e-02 | 1.170 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 6.820738e-02 | 1.166 |
| R-HSA-5673000 | RAF activation | 6.541805e-02 | 1.184 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 7.283511e-02 | 1.138 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.780522e-02 | 1.109 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.780522e-02 | 1.109 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.974146e-02 | 1.098 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.012155e-02 | 1.096 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.078218e-02 | 1.093 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.271405e-02 | 1.082 |
| R-HSA-381070 | IRE1alpha activates chaperones | 8.387940e-02 | 1.076 |
| R-HSA-170984 | ARMS-mediated activation | 1.144208e-01 | 0.941 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 1.495910e-01 | 0.825 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 1.495910e-01 | 0.825 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.495910e-01 | 0.825 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.581645e-01 | 0.801 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.666520e-01 | 0.778 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 1.916077e-01 | 0.718 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 1.916077e-01 | 0.718 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.997601e-01 | 0.699 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 1.997601e-01 | 0.699 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.078307e-01 | 0.682 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.315605e-01 | 0.635 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.393124e-01 | 0.621 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.393124e-01 | 0.621 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.469865e-01 | 0.607 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.376498e-01 | 0.861 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.445523e-01 | 0.840 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.842182e-01 | 0.546 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.056729e-01 | 0.515 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.126815e-01 | 0.505 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.126815e-01 | 0.505 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.264883e-01 | 0.486 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.264883e-01 | 0.486 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.332881e-01 | 0.477 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.500833e-01 | 0.602 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.750545e-01 | 0.757 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.400196e-01 | 0.468 |
| R-HSA-3000157 | Laminin interactions | 2.695503e-01 | 0.569 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.044107e-01 | 0.981 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.400196e-01 | 0.468 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.315605e-01 | 0.635 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.078307e-01 | 0.682 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.238554e-01 | 0.650 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.495910e-01 | 0.825 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.997601e-01 | 0.699 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.240809e-01 | 0.906 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.621047e-01 | 0.582 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.274418e-01 | 0.895 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.842182e-01 | 0.546 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.948750e-01 | 0.530 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.532748e-01 | 0.596 |
| R-HSA-69190 | DNA strand elongation | 3.196197e-01 | 0.495 |
| R-HSA-9694614 | Attachment and Entry | 2.393124e-01 | 0.621 |
| R-HSA-73886 | Chromosome Maintenance | 1.578315e-01 | 0.802 |
| R-HSA-390696 | Adrenoceptors | 1.054046e-01 | 0.977 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.769212e-01 | 0.558 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.196197e-01 | 0.495 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.332881e-01 | 0.477 |
| R-HSA-157579 | Telomere Maintenance | 2.985985e-01 | 0.525 |
| R-HSA-2024096 | HS-GAG degradation | 3.196197e-01 | 0.495 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.018831e-01 | 0.695 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.750545e-01 | 0.757 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.621047e-01 | 0.582 |
| R-HSA-169893 | Prolonged ERK activation events | 1.833728e-01 | 0.737 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.769212e-01 | 0.558 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.056729e-01 | 0.515 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.400196e-01 | 0.468 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.400196e-01 | 0.468 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.126815e-01 | 0.505 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.245617e-01 | 0.489 |
| R-HSA-9026762 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | 9.629728e-02 | 1.016 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.233466e-01 | 0.909 |
| R-HSA-69091 | Polymerase switching | 1.495910e-01 | 0.825 |
| R-HSA-69109 | Leading Strand Synthesis | 1.495910e-01 | 0.825 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.621047e-01 | 0.582 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.145030e-01 | 0.941 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.836897e-01 | 0.547 |
| R-HSA-3214842 | HDMs demethylate histones | 2.695503e-01 | 0.569 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.410919e-01 | 0.850 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.344782e-01 | 0.630 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.158205e-01 | 0.666 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.985933e-01 | 0.525 |
| R-HSA-68882 | Mitotic Anaphase | 9.299323e-02 | 1.032 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.425033e-02 | 1.026 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.240299e-01 | 0.650 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 9.629728e-02 | 1.016 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.144208e-01 | 0.941 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 1.233466e-01 | 0.909 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.666520e-01 | 0.778 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.750545e-01 | 0.757 |
| R-HSA-6811438 | Intra-Golgi traffic | 8.875915e-02 | 1.052 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.769212e-01 | 0.558 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.545837e-01 | 0.594 |
| R-HSA-182971 | EGFR downregulation | 3.126815e-01 | 0.505 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.609044e-01 | 0.793 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.079343e-01 | 0.967 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.233466e-01 | 0.909 |
| R-HSA-975577 | N-Glycan antennae elongation | 1.833728e-01 | 0.737 |
| R-HSA-375280 | Amine ligand-binding receptors | 9.806232e-02 | 1.008 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.695503e-01 | 0.569 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.869210e-01 | 0.728 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.095773e-01 | 0.679 |
| R-HSA-9659379 | Sensory processing of sound | 2.203238e-01 | 0.657 |
| R-HSA-69275 | G2/M Transition | 1.555581e-01 | 0.808 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.593638e-01 | 0.798 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.666520e-01 | 0.778 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.393124e-01 | 0.621 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 2.769212e-01 | 0.558 |
| R-HSA-622312 | Inflammasomes | 2.914420e-01 | 0.535 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.126815e-01 | 0.505 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.800209e-01 | 0.745 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.624463e-01 | 0.581 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 8.572027e-02 | 1.067 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.515258e-01 | 0.820 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.535875e-02 | 1.021 |
| R-HSA-877300 | Interferon gamma signaling | 1.063003e-01 | 0.973 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.376498e-01 | 0.861 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.277409e-01 | 0.643 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.032148e-01 | 0.986 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.997601e-01 | 0.699 |
| R-HSA-9833110 | RSV-host interactions | 3.282527e-01 | 0.484 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.240809e-01 | 0.906 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.144208e-01 | 0.941 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.750545e-01 | 0.757 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.997601e-01 | 0.699 |
| R-HSA-9629569 | Protein hydroxylation | 2.237302e-01 | 0.650 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.769212e-01 | 0.558 |
| R-HSA-2559583 | Cellular Senescence | 1.443548e-01 | 0.841 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.158205e-01 | 0.666 |
| R-HSA-114608 | Platelet degranulation | 1.749894e-01 | 0.757 |
| R-HSA-74160 | Gene expression (Transcription) | 1.500643e-01 | 0.824 |
| R-HSA-597592 | Post-translational protein modification | 1.264041e-01 | 0.898 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.392926e-01 | 0.469 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.495910e-01 | 0.825 |
| R-HSA-9026395 | Biosynthesis of DHA-derived sulfido conjugates | 2.078307e-01 | 0.682 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.332881e-01 | 0.477 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.158205e-01 | 0.666 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.926425e-01 | 0.715 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.392926e-01 | 0.469 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.108128e-01 | 0.508 |
| R-HSA-73942 | DNA Damage Reversal | 1.750545e-01 | 0.757 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.426243e-01 | 0.615 |
| R-HSA-5358508 | Mismatch Repair | 2.078307e-01 | 0.682 |
| R-HSA-5578775 | Ion homeostasis | 1.376498e-01 | 0.861 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.656636e-01 | 0.781 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.874203e-01 | 0.541 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.158205e-01 | 0.666 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.055159e-01 | 0.687 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.189677e-01 | 0.496 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.129280e-01 | 0.672 |
| R-HSA-5620971 | Pyroptosis | 2.914420e-01 | 0.535 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.018831e-01 | 0.695 |
| R-HSA-162582 | Signal Transduction | 1.760900e-01 | 0.754 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.051481e-01 | 0.515 |
| R-HSA-111885 | Opioid Signalling | 1.121798e-01 | 0.950 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.762240e-01 | 0.559 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 1.240548e-01 | 0.906 |
| R-HSA-109581 | Apoptosis | 2.750103e-01 | 0.561 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.394632e-01 | 0.621 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.985985e-01 | 0.525 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.107204e-01 | 0.676 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.687544e-01 | 0.571 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.429607e-01 | 0.465 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.466835e-01 | 0.460 |
| R-HSA-187687 | Signalling to ERKs | 3.466835e-01 | 0.460 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.532805e-01 | 0.452 |
| R-HSA-2022928 | HS-GAG biosynthesis | 3.532805e-01 | 0.452 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.532805e-01 | 0.452 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.532805e-01 | 0.452 |
| R-HSA-5617833 | Cilium Assembly | 3.547715e-01 | 0.450 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.598114e-01 | 0.444 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.598114e-01 | 0.444 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.662767e-01 | 0.436 |
| R-HSA-9931953 | Biofilm formation | 3.662767e-01 | 0.436 |
| R-HSA-8875878 | MET promotes cell motility | 3.662767e-01 | 0.436 |
| R-HSA-199991 | Membrane Trafficking | 3.665838e-01 | 0.436 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.726771e-01 | 0.429 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.726771e-01 | 0.429 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.726771e-01 | 0.429 |
| R-HSA-112316 | Neuronal System | 3.750848e-01 | 0.426 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.790132e-01 | 0.421 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.790132e-01 | 0.421 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.790132e-01 | 0.421 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.790132e-01 | 0.421 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.790132e-01 | 0.421 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.790132e-01 | 0.421 |
| R-HSA-5260271 | Diseases of Immune System | 3.790132e-01 | 0.421 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.790132e-01 | 0.421 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 3.790132e-01 | 0.421 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.792522e-01 | 0.421 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.792522e-01 | 0.421 |
| R-HSA-373760 | L1CAM interactions | 3.792522e-01 | 0.421 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.821803e-01 | 0.418 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.828377e-01 | 0.417 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.852858e-01 | 0.414 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.852858e-01 | 0.414 |
| R-HSA-9694548 | Maturation of spike protein | 3.852858e-01 | 0.414 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.852858e-01 | 0.414 |
| R-HSA-913531 | Interferon Signaling | 3.888407e-01 | 0.410 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.914953e-01 | 0.407 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.914953e-01 | 0.407 |
| R-HSA-68875 | Mitotic Prophase | 3.935406e-01 | 0.405 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.976426e-01 | 0.401 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.976426e-01 | 0.401 |
| R-HSA-5357801 | Programmed Cell Death | 3.985099e-01 | 0.400 |
| R-HSA-9710421 | Defective pyroptosis | 4.037281e-01 | 0.394 |
| R-HSA-9907900 | Proteasome assembly | 4.097524e-01 | 0.387 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.097524e-01 | 0.387 |
| R-HSA-392499 | Metabolism of proteins | 4.121876e-01 | 0.385 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.157163e-01 | 0.381 |
| R-HSA-774815 | Nucleosome assembly | 4.157163e-01 | 0.381 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.157163e-01 | 0.381 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.157163e-01 | 0.381 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.157163e-01 | 0.381 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.216203e-01 | 0.375 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.216203e-01 | 0.375 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.216203e-01 | 0.375 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.216203e-01 | 0.375 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.216203e-01 | 0.375 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.274650e-01 | 0.369 |
| R-HSA-1483191 | Synthesis of PC | 4.274650e-01 | 0.369 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.332510e-01 | 0.363 |
| R-HSA-5576891 | Cardiac conduction | 4.388963e-01 | 0.358 |
| R-HSA-73893 | DNA Damage Bypass | 4.389789e-01 | 0.358 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.423103e-01 | 0.354 |
| R-HSA-9748787 | Azathioprine ADME | 4.446493e-01 | 0.352 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.558196e-01 | 0.341 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.584039e-01 | 0.339 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.592076e-01 | 0.338 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.633378e-01 | 0.334 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.658838e-01 | 0.332 |
| R-HSA-72649 | Translation initiation complex formation | 4.667667e-01 | 0.331 |
| R-HSA-156588 | Glucuronidation | 4.667667e-01 | 0.331 |
| R-HSA-6807070 | PTEN Regulation | 4.692038e-01 | 0.329 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.721578e-01 | 0.326 |
| R-HSA-9753281 | Paracetamol ADME | 4.721578e-01 | 0.326 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.724768e-01 | 0.326 |
| R-HSA-211859 | Biological oxidations | 4.736915e-01 | 0.325 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.754313e-01 | 0.323 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.758070e-01 | 0.323 |
| R-HSA-1474244 | Extracellular matrix organization | 4.760501e-01 | 0.322 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.774948e-01 | 0.321 |
| R-HSA-177929 | Signaling by EGFR | 4.774948e-01 | 0.321 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.823607e-01 | 0.317 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.880084e-01 | 0.312 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.880084e-01 | 0.312 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.880084e-01 | 0.312 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 4.931861e-01 | 0.307 |
| R-HSA-191859 | snRNP Assembly | 4.931861e-01 | 0.307 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.931861e-01 | 0.307 |
| R-HSA-180786 | Extension of Telomeres | 4.931861e-01 | 0.307 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.953166e-01 | 0.305 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.983118e-01 | 0.302 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.033859e-01 | 0.298 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.080668e-01 | 0.294 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.084090e-01 | 0.294 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.084090e-01 | 0.294 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.084090e-01 | 0.294 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.084090e-01 | 0.294 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.084090e-01 | 0.294 |
| R-HSA-186797 | Signaling by PDGF | 5.084090e-01 | 0.294 |
| R-HSA-373755 | Semaphorin interactions | 5.133816e-01 | 0.290 |
| R-HSA-4839726 | Chromatin organization | 5.134535e-01 | 0.289 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.174918e-01 | 0.286 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.183042e-01 | 0.285 |
| R-HSA-1989781 | PPARA activates gene expression | 5.237088e-01 | 0.281 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.280015e-01 | 0.277 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.280015e-01 | 0.277 |
| R-HSA-9679506 | SARS-CoV Infections | 5.292171e-01 | 0.276 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.298723e-01 | 0.276 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.327771e-01 | 0.273 |
| R-HSA-5218859 | Regulated Necrosis | 5.375046e-01 | 0.270 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.421847e-01 | 0.266 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.468177e-01 | 0.262 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.468177e-01 | 0.262 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.468177e-01 | 0.262 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.514040e-01 | 0.259 |
| R-HSA-3000178 | ECM proteoglycans | 5.514040e-01 | 0.259 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.514040e-01 | 0.259 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.559443e-01 | 0.255 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.604388e-01 | 0.251 |
| R-HSA-4086398 | Ca2+ pathway | 5.604388e-01 | 0.251 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.692928e-01 | 0.245 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.692928e-01 | 0.245 |
| R-HSA-72306 | tRNA processing | 5.714908e-01 | 0.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.734357e-01 | 0.242 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.736530e-01 | 0.241 |
| R-HSA-5689603 | UCH proteinases | 5.736530e-01 | 0.241 |
| R-HSA-418555 | G alpha (s) signalling events | 5.743601e-01 | 0.241 |
| R-HSA-216083 | Integrin cell surface interactions | 5.822424e-01 | 0.235 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.822424e-01 | 0.235 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.828847e-01 | 0.234 |
| R-HSA-6806834 | Signaling by MET | 5.906597e-01 | 0.229 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 5.948050e-01 | 0.226 |
| R-HSA-977225 | Amyloid fiber formation | 5.948050e-01 | 0.226 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 5.948050e-01 | 0.226 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.989085e-01 | 0.223 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.077060e-01 | 0.216 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.109729e-01 | 0.214 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.188148e-01 | 0.208 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.188148e-01 | 0.208 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.230892e-01 | 0.205 |
| R-HSA-983712 | Ion channel transport | 6.236260e-01 | 0.205 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.264995e-01 | 0.203 |
| R-HSA-195721 | Signaling by WNT | 6.265473e-01 | 0.203 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.302839e-01 | 0.200 |
| R-HSA-73884 | Base Excision Repair | 6.340302e-01 | 0.198 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.346096e-01 | 0.197 |
| R-HSA-9609690 | HCMV Early Events | 6.415674e-01 | 0.193 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.585440e-01 | 0.181 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.592189e-01 | 0.181 |
| R-HSA-422356 | Regulation of insulin secretion | 6.694793e-01 | 0.174 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.694793e-01 | 0.174 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.694793e-01 | 0.174 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.694793e-01 | 0.174 |
| R-HSA-70171 | Glycolysis | 6.761484e-01 | 0.170 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.761484e-01 | 0.170 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.761484e-01 | 0.170 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.794326e-01 | 0.168 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.922418e-01 | 0.160 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.922418e-01 | 0.160 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.953638e-01 | 0.158 |
| R-HSA-69239 | Synthesis of DNA | 7.015136e-01 | 0.154 |
| R-HSA-211000 | Gene Silencing by RNA | 7.015136e-01 | 0.154 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.045421e-01 | 0.152 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.045421e-01 | 0.152 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.045421e-01 | 0.152 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.075401e-01 | 0.150 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.105078e-01 | 0.148 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.105078e-01 | 0.148 |
| R-HSA-6803157 | Antimicrobial peptides | 7.134456e-01 | 0.147 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.163538e-01 | 0.145 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.172055e-01 | 0.144 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.192326e-01 | 0.143 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.220824e-01 | 0.141 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.220824e-01 | 0.141 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.276960e-01 | 0.138 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.277442e-01 | 0.138 |
| R-HSA-212436 | Generic Transcription Pathway | 7.315977e-01 | 0.136 |
| R-HSA-8939211 | ESR-mediated signaling | 7.353752e-01 | 0.133 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.353752e-01 | 0.133 |
| R-HSA-70326 | Glucose metabolism | 7.359058e-01 | 0.133 |
| R-HSA-5693538 | Homology Directed Repair | 7.385873e-01 | 0.132 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.412418e-01 | 0.130 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.412418e-01 | 0.130 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.490456e-01 | 0.125 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.490456e-01 | 0.125 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.515946e-01 | 0.124 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.515946e-01 | 0.124 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.541177e-01 | 0.123 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.590880e-01 | 0.120 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.590880e-01 | 0.120 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.590880e-01 | 0.120 |
| R-HSA-9609646 | HCMV Infection | 7.598700e-01 | 0.119 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.663567e-01 | 0.116 |
| R-HSA-5688426 | Deubiquitination | 7.687596e-01 | 0.114 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.779900e-01 | 0.109 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.784170e-01 | 0.109 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.890474e-01 | 0.103 |
| R-HSA-163685 | Integration of energy metabolism | 7.890474e-01 | 0.103 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.974979e-01 | 0.098 |
| R-HSA-9664407 | Parasite infection | 7.974979e-01 | 0.098 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.974979e-01 | 0.098 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.036141e-01 | 0.095 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.056118e-01 | 0.094 |
| R-HSA-446728 | Cell junction organization | 8.060695e-01 | 0.094 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.105230e-01 | 0.091 |
| R-HSA-9658195 | Leishmania infection | 8.105230e-01 | 0.091 |
| R-HSA-418594 | G alpha (i) signalling events | 8.105276e-01 | 0.091 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.119872e-01 | 0.090 |
| R-HSA-168249 | Innate Immune System | 8.126628e-01 | 0.090 |
| R-HSA-2187338 | Visual phototransduction | 8.134025e-01 | 0.090 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.153012e-01 | 0.089 |
| R-HSA-69242 | S Phase | 8.153012e-01 | 0.089 |
| R-HSA-166520 | Signaling by NTRKs | 8.153012e-01 | 0.089 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.190412e-01 | 0.087 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.227059e-01 | 0.085 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.227059e-01 | 0.085 |
| R-HSA-69306 | DNA Replication | 8.245104e-01 | 0.084 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.262968e-01 | 0.083 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.280650e-01 | 0.082 |
| R-HSA-9612973 | Autophagy | 8.298154e-01 | 0.081 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.301280e-01 | 0.081 |
| R-HSA-9610379 | HCMV Late Events | 8.315481e-01 | 0.080 |
| R-HSA-162587 | HIV Life Cycle | 8.315481e-01 | 0.080 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.366415e-01 | 0.077 |
| R-HSA-5619102 | SLC transporter disorders | 8.479388e-01 | 0.072 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.570019e-01 | 0.067 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.584593e-01 | 0.066 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.584593e-01 | 0.066 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.584593e-01 | 0.066 |
| R-HSA-611105 | Respiratory electron transport | 8.655279e-01 | 0.063 |
| R-HSA-168255 | Influenza Infection | 8.668989e-01 | 0.062 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.710343e-01 | 0.060 |
| R-HSA-3781865 | Diseases of glycosylation | 8.735485e-01 | 0.059 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.823067e-01 | 0.054 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.846964e-01 | 0.053 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.881908e-01 | 0.051 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.926869e-01 | 0.049 |
| R-HSA-428157 | Sphingolipid metabolism | 8.937825e-01 | 0.049 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.959405e-01 | 0.048 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.959405e-01 | 0.048 |
| R-HSA-9824446 | Viral Infection Pathways | 9.010929e-01 | 0.045 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.017284e-01 | 0.045 |
| R-HSA-388396 | GPCR downstream signalling | 9.086761e-01 | 0.042 |
| R-HSA-418990 | Adherens junctions interactions | 9.117072e-01 | 0.040 |
| R-HSA-9748784 | Drug ADME | 9.117072e-01 | 0.040 |
| R-HSA-109582 | Hemostasis | 9.141102e-01 | 0.039 |
| R-HSA-8951664 | Neddylation | 9.143874e-01 | 0.039 |
| R-HSA-162906 | HIV Infection | 9.195075e-01 | 0.036 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.221060e-01 | 0.035 |
| R-HSA-168256 | Immune System | 9.231245e-01 | 0.035 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.246718e-01 | 0.034 |
| R-HSA-422475 | Axon guidance | 9.283052e-01 | 0.032 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.344748e-01 | 0.029 |
| R-HSA-421270 | Cell-cell junction organization | 9.371182e-01 | 0.028 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.402738e-01 | 0.027 |
| R-HSA-72766 | Translation | 9.439719e-01 | 0.025 |
| R-HSA-9675108 | Nervous system development | 9.457006e-01 | 0.024 |
| R-HSA-372790 | Signaling by GPCR | 9.459032e-01 | 0.024 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.523902e-01 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.551742e-01 | 0.020 |
| R-HSA-1483257 | Phospholipid metabolism | 9.600504e-01 | 0.018 |
| R-HSA-449147 | Signaling by Interleukins | 9.609886e-01 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.751711e-01 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.804362e-01 | 0.009 |
| R-HSA-5663205 | Infectious disease | 9.829429e-01 | 0.007 |
| R-HSA-1280218 | Adaptive Immune System | 9.852647e-01 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 9.863053e-01 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 9.899389e-01 | 0.004 |
| R-HSA-1266738 | Developmental Biology | 9.965936e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.980190e-01 | 0.001 |
| R-HSA-1643685 | Disease | 9.983371e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.995471e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998087e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.826 | 0.501 | 2 | 0.886 |
COT |
0.802 | 0.192 | 2 | 0.682 |
BMPR1B |
0.801 | 0.404 | 1 | 0.744 |
TGFBR1 |
0.794 | 0.459 | -2 | 0.889 |
DSTYK |
0.793 | 0.240 | 2 | 0.708 |
BMPR1A |
0.792 | 0.415 | 1 | 0.721 |
CLK3 |
0.790 | 0.148 | 1 | 0.818 |
ALK2 |
0.789 | 0.472 | -2 | 0.880 |
GRK7 |
0.788 | 0.329 | 1 | 0.717 |
GRK1 |
0.787 | 0.186 | -2 | 0.662 |
CAMK2G |
0.785 | 0.170 | 2 | 0.693 |
GRK6 |
0.784 | 0.258 | 1 | 0.779 |
ACVR2A |
0.784 | 0.355 | -2 | 0.867 |
CK2A2 |
0.783 | 0.412 | 1 | 0.645 |
ALK4 |
0.783 | 0.396 | -2 | 0.884 |
IKKA |
0.783 | 0.169 | -2 | 0.590 |
GRK4 |
0.782 | 0.142 | -2 | 0.728 |
IKKB |
0.782 | 0.070 | -2 | 0.586 |
ACVR2B |
0.780 | 0.330 | -2 | 0.867 |
TGFBR2 |
0.780 | 0.203 | -2 | 0.882 |
PLK3 |
0.780 | 0.257 | 2 | 0.638 |
ATM |
0.779 | 0.174 | 1 | 0.784 |
CDC7 |
0.775 | -0.007 | 1 | 0.786 |
GRK5 |
0.775 | 0.082 | -3 | 0.813 |
CK2A1 |
0.775 | 0.378 | 1 | 0.625 |
PLK1 |
0.775 | 0.215 | -2 | 0.775 |
BMPR2 |
0.774 | 0.164 | -2 | 0.764 |
PRPK |
0.774 | -0.032 | -1 | 0.830 |
CAMK2B |
0.773 | 0.184 | 2 | 0.745 |
MOS |
0.773 | 0.020 | 1 | 0.802 |
ATR |
0.772 | 0.070 | 1 | 0.831 |
GCN2 |
0.771 | -0.034 | 2 | 0.546 |
NEK6 |
0.771 | 0.060 | -2 | 0.762 |
NEK7 |
0.771 | 0.041 | -3 | 0.807 |
MTOR |
0.771 | -0.039 | 1 | 0.764 |
KIS |
0.770 | 0.030 | 1 | 0.674 |
TBK1 |
0.770 | -0.036 | 1 | 0.696 |
RAF1 |
0.770 | -0.070 | 1 | 0.789 |
PIM3 |
0.770 | -0.002 | -3 | 0.721 |
IKKE |
0.769 | -0.033 | 1 | 0.687 |
PDHK4 |
0.769 | -0.073 | 1 | 0.806 |
NDR2 |
0.767 | -0.031 | -3 | 0.713 |
PLK2 |
0.766 | 0.217 | -3 | 0.826 |
DNAPK |
0.765 | 0.150 | 1 | 0.738 |
ULK2 |
0.764 | -0.095 | 2 | 0.523 |
MLK1 |
0.763 | -0.064 | 2 | 0.569 |
SKMLCK |
0.762 | -0.024 | -2 | 0.644 |
CAMK1B |
0.762 | -0.065 | -3 | 0.756 |
GRK2 |
0.762 | 0.074 | -2 | 0.657 |
RSK2 |
0.761 | -0.001 | -3 | 0.641 |
HUNK |
0.761 | -0.069 | 2 | 0.600 |
GRK3 |
0.760 | 0.106 | -2 | 0.648 |
SRPK1 |
0.759 | -0.005 | -3 | 0.632 |
CLK2 |
0.759 | 0.082 | -3 | 0.630 |
NLK |
0.759 | -0.095 | 1 | 0.795 |
TLK2 |
0.759 | 0.154 | 1 | 0.755 |
ERK5 |
0.758 | -0.063 | 1 | 0.765 |
ULK1 |
0.758 | -0.075 | -3 | 0.777 |
PIM1 |
0.758 | 0.003 | -3 | 0.663 |
CDKL1 |
0.757 | -0.059 | -3 | 0.696 |
CAMK2A |
0.757 | 0.076 | 2 | 0.709 |
PDHK1 |
0.756 | -0.159 | 1 | 0.792 |
TTBK2 |
0.756 | -0.057 | 2 | 0.476 |
CAMLCK |
0.755 | -0.080 | -2 | 0.658 |
CAMK2D |
0.754 | 0.004 | -3 | 0.715 |
SRPK3 |
0.754 | -0.004 | -3 | 0.625 |
SRPK2 |
0.754 | 0.002 | -3 | 0.559 |
PKN3 |
0.753 | -0.073 | -3 | 0.715 |
LATS1 |
0.753 | 0.106 | -3 | 0.718 |
RIPK3 |
0.753 | -0.184 | 3 | 0.547 |
MARK4 |
0.753 | -0.056 | 4 | 0.783 |
LATS2 |
0.752 | -0.011 | -5 | 0.686 |
JNK3 |
0.751 | 0.044 | 1 | 0.635 |
MLK3 |
0.751 | -0.060 | 2 | 0.508 |
NIK |
0.751 | -0.181 | -3 | 0.782 |
CDK8 |
0.750 | -0.013 | 1 | 0.653 |
NDR1 |
0.750 | -0.117 | -3 | 0.705 |
P90RSK |
0.750 | -0.056 | -3 | 0.646 |
MLK4 |
0.750 | -0.024 | 2 | 0.486 |
DLK |
0.749 | -0.113 | 1 | 0.786 |
MST4 |
0.749 | -0.112 | 2 | 0.603 |
ANKRD3 |
0.749 | -0.117 | 1 | 0.809 |
WNK1 |
0.748 | -0.163 | -2 | 0.624 |
DAPK2 |
0.748 | -0.122 | -3 | 0.758 |
PKCD |
0.747 | -0.080 | 2 | 0.540 |
SMG1 |
0.747 | 0.007 | 1 | 0.799 |
CDK1 |
0.747 | 0.009 | 1 | 0.618 |
CLK4 |
0.747 | -0.005 | -3 | 0.644 |
RSK4 |
0.747 | -0.002 | -3 | 0.617 |
MASTL |
0.747 | -0.234 | -2 | 0.620 |
PKACG |
0.747 | -0.068 | -2 | 0.594 |
JNK2 |
0.746 | 0.032 | 1 | 0.604 |
NEK9 |
0.746 | -0.166 | 2 | 0.558 |
NUAK2 |
0.746 | -0.130 | -3 | 0.726 |
TLK1 |
0.746 | 0.092 | -2 | 0.815 |
GSK3A |
0.746 | 0.082 | 4 | 0.517 |
PRKX |
0.746 | 0.019 | -3 | 0.543 |
CHAK2 |
0.746 | -0.140 | -1 | 0.785 |
AURA |
0.745 | -0.025 | -2 | 0.496 |
ICK |
0.745 | -0.081 | -3 | 0.720 |
BCKDK |
0.745 | -0.139 | -1 | 0.741 |
MEK1 |
0.744 | -0.098 | 2 | 0.608 |
TSSK2 |
0.744 | -0.091 | -5 | 0.710 |
PKR |
0.744 | -0.082 | 1 | 0.804 |
CDKL5 |
0.743 | -0.091 | -3 | 0.676 |
NIM1 |
0.743 | -0.119 | 3 | 0.560 |
IRE2 |
0.743 | -0.101 | 2 | 0.475 |
RSK3 |
0.743 | -0.087 | -3 | 0.640 |
BRAF |
0.743 | 0.016 | -4 | 0.783 |
MAPKAPK2 |
0.743 | 0.008 | -3 | 0.587 |
PRKD1 |
0.742 | -0.106 | -3 | 0.670 |
PERK |
0.742 | 0.013 | -2 | 0.800 |
WNK3 |
0.742 | -0.267 | 1 | 0.772 |
MSK1 |
0.742 | -0.025 | -3 | 0.615 |
P70S6KB |
0.742 | -0.091 | -3 | 0.673 |
MEKK3 |
0.742 | -0.074 | 1 | 0.757 |
DRAK1 |
0.742 | -0.048 | 1 | 0.739 |
PAK1 |
0.741 | -0.087 | -2 | 0.576 |
P38B |
0.741 | 0.010 | 1 | 0.614 |
PLK4 |
0.741 | -0.066 | 2 | 0.406 |
MSK2 |
0.740 | -0.066 | -3 | 0.612 |
DYRK2 |
0.740 | -0.031 | 1 | 0.667 |
PKACB |
0.740 | -0.027 | -2 | 0.540 |
RIPK1 |
0.740 | -0.233 | 1 | 0.782 |
PKN2 |
0.740 | -0.160 | -3 | 0.721 |
AMPKA1 |
0.740 | -0.133 | -3 | 0.726 |
HIPK4 |
0.740 | -0.106 | 1 | 0.753 |
CK1E |
0.739 | -0.013 | -3 | 0.582 |
YSK4 |
0.739 | -0.126 | 1 | 0.732 |
CDK19 |
0.739 | -0.032 | 1 | 0.620 |
AURC |
0.739 | -0.071 | -2 | 0.520 |
IRE1 |
0.738 | -0.179 | 1 | 0.770 |
CK1D |
0.738 | 0.011 | -3 | 0.536 |
PINK1 |
0.737 | -0.069 | 1 | 0.796 |
CLK1 |
0.737 | -0.029 | -3 | 0.614 |
P38G |
0.737 | 0.011 | 1 | 0.535 |
PRKD2 |
0.736 | -0.102 | -3 | 0.624 |
MLK2 |
0.736 | -0.228 | 2 | 0.557 |
P38A |
0.736 | -0.029 | 1 | 0.680 |
CDK5 |
0.736 | -0.027 | 1 | 0.673 |
TSSK1 |
0.736 | -0.114 | -3 | 0.741 |
PASK |
0.736 | -0.004 | -3 | 0.748 |
HRI |
0.736 | -0.066 | -2 | 0.788 |
MARK2 |
0.736 | -0.046 | 4 | 0.684 |
DYRK4 |
0.735 | 0.007 | 1 | 0.602 |
MYLK4 |
0.735 | -0.088 | -2 | 0.585 |
VRK2 |
0.735 | -0.293 | 1 | 0.828 |
GSK3B |
0.735 | 0.022 | 4 | 0.506 |
MEKK2 |
0.735 | -0.094 | 2 | 0.542 |
CK1G1 |
0.735 | -0.030 | -3 | 0.577 |
JNK1 |
0.734 | 0.030 | 1 | 0.588 |
TTBK1 |
0.734 | -0.083 | 2 | 0.430 |
CDK2 |
0.734 | -0.060 | 1 | 0.687 |
PRP4 |
0.734 | -0.020 | -3 | 0.698 |
MARK3 |
0.733 | -0.062 | 4 | 0.724 |
ERK1 |
0.733 | -0.025 | 1 | 0.608 |
AURB |
0.733 | -0.080 | -2 | 0.517 |
ERK2 |
0.733 | -0.041 | 1 | 0.655 |
CDK13 |
0.733 | -0.046 | 1 | 0.633 |
GAK |
0.732 | 0.029 | 1 | 0.814 |
PAK2 |
0.732 | -0.127 | -2 | 0.566 |
P38D |
0.732 | 0.017 | 1 | 0.570 |
PKCG |
0.732 | -0.124 | 2 | 0.498 |
PAK6 |
0.732 | -0.072 | -2 | 0.501 |
PKCA |
0.732 | -0.116 | 2 | 0.476 |
PKCB |
0.731 | -0.113 | 2 | 0.490 |
AMPKA2 |
0.731 | -0.138 | -3 | 0.687 |
NEK2 |
0.731 | -0.153 | 2 | 0.515 |
PAK3 |
0.731 | -0.159 | -2 | 0.568 |
QSK |
0.731 | -0.101 | 4 | 0.754 |
MAPKAPK3 |
0.731 | -0.115 | -3 | 0.625 |
CDK3 |
0.730 | -0.007 | 1 | 0.560 |
CK1A2 |
0.730 | -0.014 | -3 | 0.534 |
CAMK4 |
0.730 | -0.178 | -3 | 0.697 |
BRSK1 |
0.729 | -0.106 | -3 | 0.659 |
PKG2 |
0.729 | -0.083 | -2 | 0.548 |
MARK1 |
0.729 | -0.077 | 4 | 0.741 |
MEKK1 |
0.728 | -0.166 | 1 | 0.769 |
QIK |
0.728 | -0.186 | -3 | 0.719 |
ZAK |
0.728 | -0.150 | 1 | 0.748 |
PKCH |
0.728 | -0.140 | 2 | 0.467 |
NEK5 |
0.727 | -0.132 | 1 | 0.798 |
MNK2 |
0.726 | -0.144 | -2 | 0.587 |
PIM2 |
0.726 | -0.072 | -3 | 0.618 |
CDK18 |
0.726 | -0.046 | 1 | 0.596 |
PKACA |
0.726 | -0.039 | -2 | 0.506 |
MEK5 |
0.726 | -0.264 | 2 | 0.566 |
SIK |
0.726 | -0.117 | -3 | 0.633 |
CDK7 |
0.725 | -0.084 | 1 | 0.657 |
TAO3 |
0.725 | -0.099 | 1 | 0.755 |
NEK8 |
0.725 | -0.117 | 2 | 0.542 |
CHK1 |
0.724 | -0.101 | -3 | 0.692 |
CDK17 |
0.724 | -0.039 | 1 | 0.544 |
CHAK1 |
0.724 | -0.231 | 2 | 0.475 |
AKT2 |
0.724 | -0.080 | -3 | 0.564 |
CDK12 |
0.724 | -0.051 | 1 | 0.607 |
NUAK1 |
0.723 | -0.160 | -3 | 0.663 |
DCAMKL1 |
0.723 | -0.088 | -3 | 0.645 |
MNK1 |
0.723 | -0.138 | -2 | 0.610 |
PKCZ |
0.723 | -0.176 | 2 | 0.502 |
SGK3 |
0.723 | -0.094 | -3 | 0.621 |
HIPK2 |
0.722 | -0.040 | 1 | 0.587 |
SMMLCK |
0.722 | -0.112 | -3 | 0.703 |
CAMKK1 |
0.722 | -0.126 | -2 | 0.559 |
PRKD3 |
0.721 | -0.131 | -3 | 0.605 |
HIPK1 |
0.721 | -0.066 | 1 | 0.690 |
CAMK1G |
0.721 | -0.122 | -3 | 0.646 |
EEF2K |
0.721 | -0.041 | 3 | 0.592 |
MST3 |
0.720 | -0.164 | 2 | 0.576 |
MELK |
0.720 | -0.200 | -3 | 0.664 |
DCAMKL2 |
0.720 | -0.090 | -3 | 0.675 |
DYRK1B |
0.719 | -0.033 | 1 | 0.632 |
BRSK2 |
0.719 | -0.172 | -3 | 0.677 |
CDK9 |
0.719 | -0.081 | 1 | 0.642 |
DYRK1A |
0.719 | -0.076 | 1 | 0.709 |
MST2 |
0.719 | -0.073 | 1 | 0.758 |
TTK |
0.718 | 0.078 | -2 | 0.809 |
MAPKAPK5 |
0.718 | -0.149 | -3 | 0.592 |
WNK4 |
0.718 | -0.221 | -2 | 0.617 |
CDK16 |
0.717 | -0.031 | 1 | 0.560 |
TAK1 |
0.717 | -0.068 | 1 | 0.772 |
PHKG1 |
0.717 | -0.186 | -3 | 0.694 |
MPSK1 |
0.717 | -0.097 | 1 | 0.757 |
DYRK3 |
0.715 | -0.064 | 1 | 0.687 |
IRAK1 |
0.715 | -0.223 | -1 | 0.739 |
SNRK |
0.715 | -0.262 | 2 | 0.420 |
ERK7 |
0.714 | -0.074 | 2 | 0.325 |
IRAK4 |
0.714 | -0.242 | 1 | 0.779 |
CDK14 |
0.714 | -0.070 | 1 | 0.638 |
DAPK3 |
0.714 | -0.075 | -3 | 0.676 |
TAO2 |
0.713 | -0.173 | 2 | 0.591 |
GCK |
0.712 | -0.126 | 1 | 0.755 |
SSTK |
0.712 | -0.131 | 4 | 0.742 |
CAMK1D |
0.712 | -0.072 | -3 | 0.545 |
PAK4 |
0.712 | -0.095 | -2 | 0.465 |
PDK1 |
0.712 | -0.150 | 1 | 0.754 |
CAMKK2 |
0.712 | -0.166 | -2 | 0.550 |
NEK11 |
0.711 | -0.246 | 1 | 0.758 |
PDHK3_TYR |
0.711 | 0.175 | 4 | 0.856 |
PAK5 |
0.711 | -0.110 | -2 | 0.462 |
PKCT |
0.711 | -0.160 | 2 | 0.468 |
DAPK1 |
0.710 | -0.074 | -3 | 0.664 |
YANK3 |
0.710 | -0.044 | 2 | 0.329 |
AKT1 |
0.710 | -0.096 | -3 | 0.571 |
MST1 |
0.709 | -0.113 | 1 | 0.745 |
TNIK |
0.709 | -0.120 | 3 | 0.573 |
STK33 |
0.709 | -0.147 | 2 | 0.427 |
MAP2K6_TYR |
0.708 | 0.197 | -1 | 0.835 |
NEK4 |
0.708 | -0.211 | 1 | 0.760 |
MINK |
0.708 | -0.149 | 1 | 0.754 |
HIPK3 |
0.708 | -0.117 | 1 | 0.673 |
ALPHAK3 |
0.708 | 0.053 | -1 | 0.738 |
LKB1 |
0.708 | -0.196 | -3 | 0.756 |
PDHK4_TYR |
0.707 | 0.174 | 2 | 0.675 |
PKCE |
0.706 | -0.119 | 2 | 0.479 |
HGK |
0.706 | -0.166 | 3 | 0.583 |
CDK10 |
0.706 | -0.068 | 1 | 0.627 |
CK1A |
0.706 | -0.008 | -3 | 0.462 |
P70S6K |
0.705 | -0.136 | -3 | 0.577 |
SGK1 |
0.704 | -0.050 | -3 | 0.479 |
PDHK1_TYR |
0.704 | 0.139 | -1 | 0.845 |
PKCI |
0.703 | -0.176 | 2 | 0.472 |
CDK6 |
0.703 | -0.064 | 1 | 0.618 |
HPK1 |
0.703 | -0.162 | 1 | 0.745 |
MAK |
0.703 | -0.041 | -2 | 0.520 |
VRK1 |
0.703 | -0.243 | 2 | 0.593 |
MAP2K4_TYR |
0.702 | 0.069 | -1 | 0.853 |
BMPR2_TYR |
0.702 | 0.079 | -1 | 0.792 |
NEK1 |
0.702 | -0.199 | 1 | 0.767 |
MEK2 |
0.701 | -0.203 | 2 | 0.542 |
LRRK2 |
0.701 | -0.255 | 2 | 0.573 |
SLK |
0.700 | -0.153 | -2 | 0.564 |
MAP3K15 |
0.700 | -0.238 | 1 | 0.731 |
RIPK2 |
0.700 | -0.235 | 1 | 0.702 |
PHKG2 |
0.700 | -0.205 | -3 | 0.669 |
TXK |
0.699 | 0.115 | 1 | 0.767 |
KHS2 |
0.698 | -0.118 | 1 | 0.753 |
MAP2K7_TYR |
0.698 | -0.034 | 2 | 0.636 |
OSR1 |
0.698 | -0.083 | 2 | 0.523 |
MRCKB |
0.697 | -0.102 | -3 | 0.606 |
CDK4 |
0.697 | -0.069 | 1 | 0.594 |
YES1 |
0.697 | 0.063 | -1 | 0.840 |
MRCKA |
0.697 | -0.108 | -3 | 0.619 |
ROCK2 |
0.697 | -0.101 | -3 | 0.646 |
AKT3 |
0.696 | -0.088 | -3 | 0.492 |
LOK |
0.696 | -0.213 | -2 | 0.584 |
KHS1 |
0.696 | -0.157 | 1 | 0.739 |
MEKK6 |
0.696 | -0.288 | 1 | 0.755 |
DMPK1 |
0.695 | -0.074 | -3 | 0.635 |
CK1G3 |
0.695 | 0.007 | -3 | 0.424 |
SRMS |
0.695 | 0.084 | 1 | 0.778 |
EPHA4 |
0.693 | 0.055 | 2 | 0.661 |
TESK1_TYR |
0.693 | -0.125 | 3 | 0.639 |
FYN |
0.693 | 0.108 | -1 | 0.758 |
BIKE |
0.692 | -0.011 | 1 | 0.713 |
YSK1 |
0.691 | -0.213 | 2 | 0.525 |
PINK1_TYR |
0.691 | -0.117 | 1 | 0.790 |
BLK |
0.691 | 0.078 | -1 | 0.809 |
BUB1 |
0.691 | -0.103 | -5 | 0.673 |
SBK |
0.691 | -0.059 | -3 | 0.442 |
FER |
0.691 | 0.023 | 1 | 0.798 |
PKMYT1_TYR |
0.691 | -0.150 | 3 | 0.615 |
MOK |
0.690 | -0.083 | 1 | 0.698 |
CHK2 |
0.690 | -0.125 | -3 | 0.499 |
PBK |
0.690 | -0.102 | 1 | 0.739 |
PKG1 |
0.689 | -0.106 | -2 | 0.495 |
ABL2 |
0.689 | -0.006 | -1 | 0.818 |
EPHA6 |
0.689 | -0.025 | -1 | 0.779 |
HASPIN |
0.689 | -0.072 | -1 | 0.673 |
INSRR |
0.689 | 0.012 | 3 | 0.550 |
PKN1 |
0.689 | -0.163 | -3 | 0.587 |
CAMK1A |
0.688 | -0.121 | -3 | 0.521 |
FGR |
0.688 | -0.024 | 1 | 0.796 |
EPHB4 |
0.688 | -0.044 | -1 | 0.773 |
ITK |
0.686 | -0.009 | -1 | 0.779 |
CK1G2 |
0.686 | 0.014 | -3 | 0.509 |
CSF1R |
0.685 | -0.081 | 3 | 0.558 |
EPHB2 |
0.685 | 0.024 | -1 | 0.750 |
HCK |
0.685 | -0.015 | -1 | 0.802 |
RET |
0.685 | -0.126 | 1 | 0.756 |
TEC |
0.684 | 0.020 | -1 | 0.764 |
ASK1 |
0.684 | -0.194 | 1 | 0.722 |
LCK |
0.684 | 0.008 | -1 | 0.791 |
KIT |
0.683 | -0.048 | 3 | 0.566 |
EPHB1 |
0.683 | -0.031 | 1 | 0.779 |
FGFR2 |
0.682 | -0.042 | 3 | 0.592 |
YANK2 |
0.682 | -0.055 | 2 | 0.354 |
ABL1 |
0.682 | -0.057 | -1 | 0.821 |
LYN |
0.682 | 0.027 | 3 | 0.522 |
TYRO3 |
0.682 | -0.163 | 3 | 0.556 |
ROCK1 |
0.682 | -0.116 | -3 | 0.616 |
NEK3 |
0.681 | -0.250 | 1 | 0.725 |
MYO3A |
0.681 | -0.172 | 1 | 0.752 |
MERTK |
0.681 | -0.040 | 3 | 0.566 |
BMX |
0.681 | -0.009 | -1 | 0.699 |
MYO3B |
0.680 | -0.178 | 2 | 0.532 |
SRC |
0.680 | 0.042 | -1 | 0.787 |
CRIK |
0.680 | -0.092 | -3 | 0.567 |
TYK2 |
0.680 | -0.194 | 1 | 0.750 |
JAK2 |
0.679 | -0.169 | 1 | 0.750 |
EGFR |
0.679 | 0.055 | 1 | 0.620 |
EPHA5 |
0.678 | 0.038 | 2 | 0.658 |
DDR1 |
0.678 | -0.142 | 4 | 0.772 |
EPHB3 |
0.678 | -0.046 | -1 | 0.760 |
FLT1 |
0.678 | -0.027 | -1 | 0.759 |
FGFR3 |
0.678 | -0.030 | 3 | 0.576 |
LIMK2_TYR |
0.678 | -0.200 | -3 | 0.784 |
FLT3 |
0.677 | -0.100 | 3 | 0.556 |
ROS1 |
0.676 | -0.196 | 3 | 0.533 |
FGFR4 |
0.676 | 0.033 | -1 | 0.737 |
MST1R |
0.676 | -0.229 | 3 | 0.566 |
EPHA7 |
0.676 | -0.019 | 2 | 0.632 |
LIMK1_TYR |
0.676 | -0.250 | 2 | 0.598 |
BTK |
0.676 | -0.081 | -1 | 0.773 |
SYK |
0.675 | 0.076 | -1 | 0.677 |
STLK3 |
0.675 | -0.159 | 1 | 0.706 |
AAK1 |
0.675 | 0.011 | 1 | 0.623 |
ERBB2 |
0.675 | -0.057 | 1 | 0.707 |
PTK2 |
0.675 | 0.041 | -1 | 0.658 |
TNK2 |
0.674 | -0.137 | 3 | 0.529 |
TAO1 |
0.674 | -0.205 | 1 | 0.689 |
PTK2B |
0.674 | -0.015 | -1 | 0.787 |
KDR |
0.674 | -0.132 | 3 | 0.548 |
JAK3 |
0.673 | -0.147 | 1 | 0.744 |
PDGFRB |
0.673 | -0.150 | 3 | 0.564 |
EPHA3 |
0.672 | -0.068 | 2 | 0.616 |
FRK |
0.672 | -0.054 | -1 | 0.830 |
EPHA8 |
0.672 | 0.003 | -1 | 0.736 |
AXL |
0.672 | -0.133 | 3 | 0.562 |
MET |
0.672 | -0.094 | 3 | 0.550 |
FGFR1 |
0.671 | -0.129 | 3 | 0.567 |
TEK |
0.671 | -0.139 | 3 | 0.528 |
NTRK1 |
0.671 | -0.084 | -1 | 0.766 |
CSK |
0.671 | -0.043 | 2 | 0.621 |
ERBB4 |
0.669 | 0.018 | 1 | 0.637 |
MATK |
0.668 | -0.057 | -1 | 0.738 |
LTK |
0.668 | -0.117 | 3 | 0.538 |
FLT4 |
0.667 | -0.112 | 3 | 0.558 |
NEK10_TYR |
0.666 | -0.132 | 1 | 0.648 |
PTK6 |
0.665 | -0.107 | -1 | 0.737 |
ALK |
0.664 | -0.154 | 3 | 0.519 |
INSR |
0.664 | -0.103 | 3 | 0.521 |
NTRK2 |
0.664 | -0.143 | 3 | 0.556 |
NTRK3 |
0.663 | -0.081 | -1 | 0.718 |
EPHA2 |
0.663 | -0.006 | -1 | 0.687 |
WEE1_TYR |
0.663 | -0.145 | -1 | 0.718 |
DDR2 |
0.663 | -0.087 | 3 | 0.543 |
JAK1 |
0.662 | -0.176 | 1 | 0.704 |
IGF1R |
0.661 | -0.044 | 3 | 0.493 |
TNK1 |
0.660 | -0.220 | 3 | 0.542 |
EPHA1 |
0.658 | -0.154 | 3 | 0.537 |
PDGFRA |
0.657 | -0.267 | 3 | 0.552 |
TNNI3K_TYR |
0.657 | -0.185 | 1 | 0.771 |
FES |
0.646 | -0.090 | -1 | 0.684 |
ZAP70 |
0.644 | -0.031 | -1 | 0.597 |
MUSK |
0.637 | -0.164 | 1 | 0.607 |