Motif 555 (n=152)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S752 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A0JNW5 | BLTP3B | S1066 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| H7C1W4 | None | S200 | ochoa | Uncharacterized protein | None |
| H8Y6P7 | GCOM1 | S541 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
| O15056 | SYNJ2 | Y490 | psp | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15117 | FYB1 | S734 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15527 | OGG1 | S232 | psp | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| O43707 | ACTN4 | S159 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43852 | CALU | S125 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60231 | DHX16 | S106 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| O60524 | NEMF | S417 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O75131 | CPNE3 | S243 | ochoa | Copine-3 (Copine III) | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). {ECO:0000269|PubMed:20010870}. |
| O75164 | KDM4A | S410 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75717 | WDHD1 | S1041 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O95425 | SVIL | S620 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95625 | ZBTB11 | S449 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| O95793 | STAU1 | S176 | ochoa | Double-stranded RNA-binding protein Staufen homolog 1 | Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}. |
| P00747 | PLG | S477 | ochoa | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093, ECO:0000269|PubMed:6447255}.; FUNCTION: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.; FUNCTION: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403). {ECO:0000269|PubMed:21949403}.; FUNCTION: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. {ECO:0000269|PubMed:22433849}.; FUNCTION: (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374). {ECO:0000269|PubMed:31726374}. |
| P04216 | THY1 | S96 | ochoa | Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90) | May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
| P07550 | ADRB2 | S246 | ochoa|psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P08833 | IGFBP1 | S194 | ochoa|psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P09488 | GSTM1 | S27 | ochoa | Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16548513, ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:9084911}. |
| P0CAP2 | POLR2M | S144 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
| P10451 | SPP1 | S62 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10645 | CHGA | S397 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P12236 | SLC25A6 | S148 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P12814 | ACTN1 | S140 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P15311 | EZR | S66 | psp | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P15374 | UCHL3 | S130 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
| P15822 | HIVEP1 | S1213 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16157 | ANK1 | S759 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P18669 | PGAM1 | S152 | ochoa | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P23526 | AHCY | S154 | ochoa | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P25054 | APC | S2205 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28161 | GSTM2 | S27 | ochoa | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276}. |
| P28715 | ERCC5 | S453 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P31629 | HIVEP2 | S951 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35222 | CTNNB1 | S605 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35367 | HRH1 | S233 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P35609 | ACTN2 | S147 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P38398 | BRCA1 | S551 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40926 | MDH2 | S310 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41235 | HNF4A | S318 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P46100 | ATRX | S1352 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49902 | NT5C2 | S409 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50851 | LRBA | S1231 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P52209 | PGD | S129 | ochoa | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| P54578 | USP14 | S222 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P58004 | SESN2 | S279 | ochoa | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684, ECO:0000269|PubMed:35114100, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P78527 | PRKDC | S503 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01831 | XPC | S346 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02224 | CENPE | S2581 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q03013 | GSTM4 | S27 | ochoa | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}. |
| Q03188 | CENPC | S195 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08043 | ACTN3 | S154 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q12955 | ANK3 | S4350 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13009 | TIAM1 | S1410 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13200 | PSMD2 | S147 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13813 | SPTAN1 | S982 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13873 | BMPR2 | S765 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14318 | FKBP8 | S323 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14457 | BECN1 | S337 | psp | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}. |
| Q14684 | RRP1B | S350 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14692 | BMS1 | Y651 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14980 | NUMA1 | S271 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15027 | ACAP1 | S231 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q15061 | WDR43 | S437 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15149 | PLEC | S2802 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15424 | SAFB | S209 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16526 | CRY1 | S568 | ochoa | Cryptochrome-1 | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:P97784, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:22170608, ECO:0000269|PubMed:23133559, ECO:0000269|PubMed:28388406}. |
| Q2M1P5 | KIF7 | S1289 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q3KR37 | GRAMD1B | S550 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3L8U1 | CHD9 | S2059 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q567U6 | CCDC93 | S301 | ochoa | Coiled-coil domain-containing protein 93 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| Q5JRA6 | MIA3 | S1419 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5QJE6 | DNTTIP2 | S178 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T6F2 | UBAP2 | S254 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q659C4 | LARP1B | S90 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q66K14 | TBC1D9B | S463 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68DK2 | ZFYVE26 | S703 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q6P435 | None | S111 | ochoa | Putative uncharacterized SMG1-like protein | None |
| Q6VY07 | PACS1 | S529 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZU80 | CEP128 | S1073 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q709C8 | VPS13C | S737 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q76FK4 | NOL8 | S707 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z2K8 | GPRIN1 | S381 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3T8 | ZFYVE16 | S549 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z4G4 | TRMT11 | S441 | ochoa | tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (EC 2.1.1.214) (tRNA methyltransferase 11 homolog) | Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs (PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). {ECO:0000269|PubMed:37283053}. |
| Q7Z6E9 | RBBP6 | S246 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86VF7 | NRAP | S613 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q86W92 | PPFIBP1 | S434 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IV48 | ERI1 | S34 | ochoa | 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}. |
| Q8IW00 | VSTM4 | S223 | ochoa | V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv] | Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. {ECO:0000250|UniProtKB:T1NXB5}. |
| Q8IZ21 | PHACTR4 | S451 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZA0 | KIAA0319L | S1003 | ochoa | Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR) | Possible role in axon guidance through interaction with RTN4R. {ECO:0000269|PubMed:20697954}.; FUNCTION: (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. {ECO:0000269|PubMed:26814968}. |
| Q8N1F7 | NUP93 | S726 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8NC44 | RETREG2 | S132 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NG31 | KNL1 | S505 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TBA6 | GOLGA5 | S130 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8WWH5 | TRUB1 | S101 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WXX7 | AUTS2 | S149 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92854 | SEMA4D | S788 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q92887 | ABCC2 | S938 | ochoa | ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}. |
| Q93075 | TATDN2 | S257 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96BM9 | ARL8A | S150 | ochoa | ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) | Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}. |
| Q96HR8 | NAF1 | S184 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96KC8 | DNAJC1 | S492 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96L73 | NSD1 | S486 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96P11 | NSUN5 | S116 | ochoa | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}. |
| Q96Q15 | SMG1 | S115 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96RS0 | TGS1 | S89 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q9BPX3 | NCAPG | S818 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BQP7 | MGME1 | S71 | ochoa | Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}. |
| Q9BRJ6 | C7orf50 | S59 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BSL1 | UBAC1 | S332 | ochoa | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612}. |
| Q9BW71 | HIRIP3 | S530 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9H400 | LIME1 | S256 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H7N4 | SCAF1 | S738 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8H3 | TMT1A | S69 | ochoa | Thiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A) | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:34980213, ECO:0000269|PubMed:37137720}.; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. {ECO:0000269|PubMed:26185986}. |
| Q9HAU0 | PLEKHA5 | S885 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NQG6 | MIEF1 | S70 | ochoa | Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}. |
| Q9NR34 | MAN1C1 | S164 | ochoa | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) | Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. |
| Q9NS28 | RGS18 | S76 | ochoa | Regulator of G-protein signaling 18 (RGS18) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. {ECO:0000269|PubMed:11042171, ECO:0000269|PubMed:11955952}. |
| Q9NVJ2 | ARL8B | S150 | ochoa | ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:15331635, PubMed:16537643). In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion (PubMed:16537643, PubMed:16650381, PubMed:25898167, PubMed:27808481, PubMed:28325809). Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis (PubMed:22172677, PubMed:24088571, PubMed:29592961). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (PubMed:21802320). Recruits RUFY1 onto early endosomes regulating endosomes to trans-Golgi network proteins retrieval (PubMed:36282215). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes (PubMed:16537643, PubMed:25908847). Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (PubMed:21802320, PubMed:25908847). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:16650381, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:28325809, ECO:0000269|PubMed:29592961, ECO:0000269|PubMed:36282215}.; FUNCTION: (Microbial infection) During Mycobacterium tuberculosis (Mtb) infection, is required for plasma membrane repair by controlling the exocytosis of lysosomes in macrophages. ARL8B secretion pathway is crucial to control the type of cell death of the M.tuberculosis-infected macrophages, distinguishing avirulent from virulent Mtb induced necrotic cell death. {ECO:0000269|PubMed:29592961}.; FUNCTION: (Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress. {ECO:0000269|PubMed:33157038}. |
| Q9NW08 | POLR3B | S816 | ochoa | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558766). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218}. |
| Q9P244 | LRFN1 | S659 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9UGI0 | ZRANB1 | S115 | ochoa | Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:33637724}. |
| Q9UHY8 | FEZ2 | S208 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UP95 | SLC12A4 | S967 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UQC2 | GAB2 | S422 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2K1 | ZBTB1 | S395 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y3R5 | DOP1B | S654 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y4E8 | USP15 | S678 | psp | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}. |
| Q9Y4F5 | CEP170B | S1261 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5A6 | ZSCAN21 | S208 | ochoa | Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) | Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}. |
| Q9Y5Q9 | GTF3C3 | S43 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| R4GMW8 | BIVM-ERCC5 | S907 | ochoa | DNA excision repair protein ERCC-5 | None |
| P61604 | HSPE1 | S21 | Sugiyama | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
| Q14192 | FHL2 | S238 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| P13489 | RNH1 | S208 | Sugiyama | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
| P07900 | HSP90AA1 | S470 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| Q9Y3F4 | STRAP | S254 | Sugiyama | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| P35408 | PTGER4 | S354 | ELM | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P42261 | GRIA1 | S832 | SIGNOR | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| P07384 | CAPN1 | S255 | EPSD|PSP | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| Q14974 | KPNB1 | S531 | Sugiyama | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
| P55769 | SNU13 | S29 | Sugiyama | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| P51812 | RPS6KA3 | S66 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S57 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q8TBC4 | UBA3 | S420 | Sugiyama | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}. |
| Q8WUM4 | PDCD6IP | S632 | Sugiyama | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-373753 | Nephrin family interactions | 0.000009 | 5.053 |
| R-HSA-5688426 | Deubiquitination | 0.000216 | 3.666 |
| R-HSA-75153 | Apoptotic execution phase | 0.000324 | 3.490 |
| R-HSA-9656249 | Defective Base Excision Repair Associated with OGG1 | 0.000506 | 3.296 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.000601 | 3.221 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 0.000892 | 3.049 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000814 | 3.089 |
| R-HSA-1500931 | Cell-Cell communication | 0.001119 | 2.951 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.004012 | 2.397 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 0.003471 | 2.460 |
| R-HSA-373760 | L1CAM interactions | 0.003006 | 2.522 |
| R-HSA-199920 | CREB phosphorylation | 0.004362 | 2.360 |
| R-HSA-5357801 | Programmed Cell Death | 0.003215 | 2.493 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.005347 | 2.272 |
| R-HSA-444257 | RSK activation | 0.006425 | 2.192 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.005632 | 2.249 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.006425 | 2.192 |
| R-HSA-156590 | Glutathione conjugation | 0.006515 | 2.186 |
| R-HSA-186712 | Regulation of beta-cell development | 0.006191 | 2.208 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.007593 | 2.120 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.008873 | 2.052 |
| R-HSA-9657050 | Defective OGG1 Localization | 0.010686 | 1.971 |
| R-HSA-9656255 | Defective OGG1 Substrate Binding | 0.010686 | 1.971 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.010686 | 1.971 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.011617 | 1.935 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.013125 | 1.882 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.010391 | 1.983 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.012257 | 1.912 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.011617 | 1.935 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.012511 | 1.903 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.013219 | 1.879 |
| R-HSA-109581 | Apoptosis | 0.013734 | 1.862 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.014597 | 1.836 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.014098 | 1.851 |
| R-HSA-9656256 | Defective OGG1 Substrate Processing | 0.021259 | 1.672 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.021259 | 1.672 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.021259 | 1.672 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.021259 | 1.672 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.021259 | 1.672 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.021259 | 1.672 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.021259 | 1.672 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.021259 | 1.672 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.018126 | 1.742 |
| R-HSA-9675135 | Diseases of DNA repair | 0.020974 | 1.678 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.020589 | 1.686 |
| R-HSA-114608 | Platelet degranulation | 0.019269 | 1.715 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.018243 | 1.739 |
| R-HSA-162906 | HIV Infection | 0.018064 | 1.743 |
| R-HSA-2262752 | Cellular responses to stress | 0.016680 | 1.778 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.021836 | 1.661 |
| R-HSA-437239 | Recycling pathway of L1 | 0.021991 | 1.658 |
| R-HSA-9909396 | Circadian clock | 0.022534 | 1.647 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.023111 | 1.636 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.030795 | 1.512 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.025832 | 1.588 |
| R-HSA-68877 | Mitotic Prometaphase | 0.027846 | 1.555 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.027933 | 1.554 |
| R-HSA-68886 | M Phase | 0.031018 | 1.508 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.027933 | 1.554 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.029921 | 1.524 |
| R-HSA-198753 | ERK/MAPK targets | 0.032331 | 1.490 |
| R-HSA-9831926 | Nephron development | 0.025832 | 1.588 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.027417 | 1.562 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.034626 | 1.461 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.034626 | 1.461 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.036258 | 1.441 |
| R-HSA-191859 | snRNP Assembly | 0.036258 | 1.441 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.033662 | 1.473 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.033088 | 1.480 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.034439 | 1.463 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.036699 | 1.435 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.042068 | 1.376 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.042068 | 1.376 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.042068 | 1.376 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.042068 | 1.376 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.042068 | 1.376 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.042068 | 1.376 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.042068 | 1.376 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.042068 | 1.376 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 0.042068 | 1.376 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.042068 | 1.376 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.042068 | 1.376 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.042068 | 1.376 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.036982 | 1.432 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 0.042068 | 1.376 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.041850 | 1.378 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.036982 | 1.432 |
| R-HSA-597592 | Post-translational protein modification | 0.036925 | 1.433 |
| R-HSA-201451 | Signaling by BMP | 0.049628 | 1.304 |
| R-HSA-9620244 | Long-term potentiation | 0.044402 | 1.353 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.046988 | 1.328 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.049628 | 1.304 |
| R-HSA-68882 | Mitotic Anaphase | 0.043174 | 1.365 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.043908 | 1.357 |
| R-HSA-422475 | Axon guidance | 0.043021 | 1.366 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.049628 | 1.304 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.046988 | 1.328 |
| R-HSA-9830369 | Kidney development | 0.047848 | 1.320 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.046988 | 1.328 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 0.049628 | 1.304 |
| R-HSA-5679001 | Defective ABCC2 causes DJS | 0.052307 | 1.281 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.057857 | 1.238 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.052307 | 1.281 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.060698 | 1.217 |
| R-HSA-390650 | Histamine receptors | 0.052307 | 1.281 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.052321 | 1.281 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.052609 | 1.279 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.055064 | 1.259 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.057857 | 1.238 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.061029 | 1.214 |
| R-HSA-9675108 | Nervous system development | 0.061944 | 1.208 |
| R-HSA-5689603 | UCH proteinases | 0.062785 | 1.202 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.063587 | 1.197 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.063587 | 1.197 |
| R-HSA-399710 | Activation of AMPA receptors | 0.072460 | 1.140 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.082376 | 1.084 |
| R-HSA-9645135 | STAT5 Activation | 0.092187 | 1.035 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.101894 | 0.992 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.101894 | 0.992 |
| R-HSA-964827 | Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t... | 0.101894 | 0.992 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.101894 | 0.992 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.111497 | 0.953 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.139698 | 0.855 |
| R-HSA-4839744 | Signaling by APC mutants | 0.139698 | 0.855 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.139698 | 0.855 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.139698 | 0.855 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.139698 | 0.855 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.148900 | 0.827 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.148900 | 0.827 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.148900 | 0.827 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.158003 | 0.801 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.184737 | 0.733 |
| R-HSA-390522 | Striated Muscle Contraction | 0.069499 | 1.158 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.078687 | 1.104 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.210626 | 0.676 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.210626 | 0.676 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.219073 | 0.659 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.219073 | 0.659 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.227430 | 0.643 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.235698 | 0.628 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.235698 | 0.628 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.235698 | 0.628 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.235698 | 0.628 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.243878 | 0.613 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.243878 | 0.613 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.111701 | 0.952 |
| R-HSA-774815 | Nucleosome assembly | 0.111701 | 0.952 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.251971 | 0.599 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.283491 | 0.547 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.081587 | 1.088 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.081587 | 1.088 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.313690 | 0.503 |
| R-HSA-1989781 | PPARA activates gene expression | 0.117272 | 0.931 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.279772 | 0.553 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.291162 | 0.536 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.120874 | 0.918 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.078687 | 1.104 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.072520 | 1.140 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.315314 | 0.501 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.072460 | 1.140 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.130398 | 0.885 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.091484 | 1.039 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.259956 | 0.585 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.081830 | 1.087 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.098095 | 1.008 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.122208 | 0.913 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.111497 | 0.953 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.158003 | 0.801 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.094773 | 1.023 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.227430 | 0.643 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.139698 | 0.855 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.147367 | 0.832 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.283491 | 0.547 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.111497 | 0.953 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.219073 | 0.659 |
| R-HSA-964739 | N-glycan trimming and elongation in the cis-Golgi | 0.175921 | 0.755 |
| R-HSA-6798695 | Neutrophil degranulation | 0.074241 | 1.129 |
| R-HSA-525793 | Myogenesis | 0.291162 | 0.536 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.118288 | 0.927 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.155007 | 0.810 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.101894 | 0.992 |
| R-HSA-192905 | vRNP Assembly | 0.139698 | 0.855 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.148900 | 0.827 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.148900 | 0.827 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.158003 | 0.801 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.091484 | 1.039 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.259978 | 0.585 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.267900 | 0.572 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.109163 | 0.962 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.279099 | 0.554 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.162512 | 0.789 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.094773 | 1.023 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.184360 | 0.734 |
| R-HSA-447043 | Neurofascin interactions | 0.092187 | 1.035 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.069499 | 1.158 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.235698 | 0.628 |
| R-HSA-390696 | Adrenoceptors | 0.111497 | 0.953 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.275737 | 0.560 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.193112 | 0.714 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.251971 | 0.599 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.275737 | 0.560 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.133848 | 0.873 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.219073 | 0.659 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.170080 | 0.769 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.184737 | 0.733 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.088230 | 1.054 |
| R-HSA-9834899 | Specification of the neural plate border | 0.227430 | 0.643 |
| R-HSA-8951664 | Neddylation | 0.260958 | 0.583 |
| R-HSA-72312 | rRNA processing | 0.287006 | 0.542 |
| R-HSA-373755 | Semaphorin interactions | 0.177707 | 0.750 |
| R-HSA-9824272 | Somitogenesis | 0.111701 | 0.952 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.275737 | 0.560 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.178224 | 0.749 |
| R-HSA-9766229 | Degradation of CDH1 | 0.125762 | 0.900 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.102508 | 0.989 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.202088 | 0.694 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.313690 | 0.503 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.219073 | 0.659 |
| R-HSA-73894 | DNA Repair | 0.116949 | 0.932 |
| R-HSA-447038 | NrCAM interactions | 0.072460 | 1.140 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.101894 | 0.992 |
| R-HSA-9026762 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | 0.101894 | 0.992 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.130398 | 0.885 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.130398 | 0.885 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.167010 | 0.777 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.251971 | 0.599 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.240019 | 0.620 |
| R-HSA-3214842 | HDMs demethylate histones | 0.283491 | 0.547 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.313690 | 0.503 |
| R-HSA-8953854 | Metabolism of RNA | 0.314804 | 0.502 |
| R-HSA-416700 | Other semaphorin interactions | 0.184737 | 0.733 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.094773 | 1.023 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.111701 | 0.952 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.291162 | 0.536 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 0.313690 | 0.503 |
| R-HSA-73886 | Chromosome Maintenance | 0.178224 | 0.749 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.244114 | 0.612 |
| R-HSA-446728 | Cell junction organization | 0.103658 | 0.984 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.082376 | 1.084 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.082376 | 1.084 |
| R-HSA-447041 | CHL1 interactions | 0.101894 | 0.992 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.101894 | 0.992 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.120998 | 0.917 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.184737 | 0.733 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.210626 | 0.676 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.098095 | 1.008 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.173887 | 0.760 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.142264 | 0.847 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.201699 | 0.695 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.108255 | 0.966 |
| R-HSA-199991 | Membrane Trafficking | 0.184845 | 0.733 |
| R-HSA-418990 | Adherens junctions interactions | 0.253937 | 0.595 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.193459 | 0.713 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.173887 | 0.760 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.066365 | 1.178 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.291162 | 0.536 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.153317 | 0.814 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.153317 | 0.814 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.303498 | 0.518 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.279490 | 0.554 |
| R-HSA-168255 | Influenza Infection | 0.165486 | 0.781 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.193459 | 0.713 |
| R-HSA-9755088 | Ribavirin ADME | 0.251971 | 0.599 |
| R-HSA-9753281 | Paracetamol ADME | 0.147574 | 0.831 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.291162 | 0.536 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.181012 | 0.742 |
| R-HSA-73927 | Depurination | 0.085011 | 1.071 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.235698 | 0.628 |
| R-HSA-9659379 | Sensory processing of sound | 0.240159 | 0.620 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.079608 | 1.099 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.251971 | 0.599 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.267900 | 0.572 |
| R-HSA-1640170 | Cell Cycle | 0.162968 | 0.788 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.159930 | 0.796 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.175921 | 0.755 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.066521 | 1.177 |
| R-HSA-2161541 | Abacavir metabolism | 0.243878 | 0.613 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.251971 | 0.599 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.196991 | 0.706 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.085011 | 1.071 |
| R-HSA-69306 | DNA Replication | 0.113719 | 0.944 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.275737 | 0.560 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.275737 | 0.560 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.075714 | 1.121 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.182353 | 0.739 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.101894 | 0.992 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.151281 | 0.820 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.298752 | 0.525 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.298752 | 0.525 |
| R-HSA-8852135 | Protein ubiquitination | 0.224378 | 0.649 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.158003 | 0.801 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.068190 | 1.166 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.213573 | 0.670 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.120998 | 0.917 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.139698 | 0.855 |
| R-HSA-392499 | Metabolism of proteins | 0.090071 | 1.045 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.247408 | 0.607 |
| R-HSA-9830364 | Formation of the nephric duct | 0.283491 | 0.547 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.319243 | 0.496 |
| R-HSA-1266738 | Developmental Biology | 0.285192 | 0.545 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.111497 | 0.953 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.175921 | 0.755 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.184737 | 0.733 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.210626 | 0.676 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.088230 | 1.054 |
| R-HSA-2161522 | Abacavir ADME | 0.291162 | 0.536 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.291162 | 0.536 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.313690 | 0.503 |
| R-HSA-381042 | PERK regulates gene expression | 0.075583 | 1.122 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.227430 | 0.643 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.104837 | 0.979 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.252032 | 0.599 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.255993 | 0.592 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.277485 | 0.557 |
| R-HSA-5619084 | ABC transporter disorders | 0.236208 | 0.627 |
| R-HSA-9754706 | Atorvastatin ADME | 0.193459 | 0.713 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.208683 | 0.681 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.126365 | 0.898 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.298752 | 0.525 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.143885 | 0.842 |
| R-HSA-9026395 | Biosynthesis of DHA-derived sulfido conjugates | 0.219073 | 0.659 |
| R-HSA-5218859 | Regulated Necrosis | 0.196991 | 0.706 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.130398 | 0.885 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.177707 | 0.750 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.235698 | 0.628 |
| R-HSA-3000170 | Syndecan interactions | 0.267900 | 0.572 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.283491 | 0.547 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.139797 | 0.855 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.319243 | 0.496 |
| R-HSA-73884 | Base Excision Repair | 0.287691 | 0.541 |
| R-HSA-186797 | Signaling by PDGF | 0.173887 | 0.760 |
| R-HSA-450294 | MAP kinase activation | 0.170080 | 0.769 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.270409 | 0.568 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.088230 | 1.054 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.098095 | 1.008 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.113690 | 0.944 |
| R-HSA-448424 | Interleukin-17 signaling | 0.204777 | 0.689 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.113690 | 0.944 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.113690 | 0.944 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.072520 | 1.140 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.142264 | 0.847 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.227430 | 0.643 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.144746 | 0.839 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.172938 | 0.762 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.144746 | 0.839 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.172938 | 0.762 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.180883 | 0.743 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.132485 | 0.878 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.180883 | 0.743 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.152277 | 0.817 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.159930 | 0.796 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.136570 | 0.865 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.083587 | 1.078 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.282002 | 0.550 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.212596 | 0.672 |
| R-HSA-9707616 | Heme signaling | 0.173887 | 0.760 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.230372 | 0.638 |
| R-HSA-168249 | Innate Immune System | 0.201798 | 0.695 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.096023 | 1.018 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.264633 | 0.577 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.178224 | 0.749 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.219073 | 0.659 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.220444 | 0.657 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.248072 | 0.605 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.088230 | 1.054 |
| R-HSA-166520 | Signaling by NTRKs | 0.264633 | 0.577 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.259978 | 0.585 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.148078 | 0.830 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.291647 | 0.535 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.298752 | 0.525 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.210665 | 0.676 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.321040 | 0.493 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.321040 | 0.493 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.321040 | 0.493 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.321040 | 0.493 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.323167 | 0.491 |
| R-HSA-1474244 | Extracellular matrix organization | 0.326007 | 0.487 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.328312 | 0.484 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.328312 | 0.484 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.328312 | 0.484 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.328312 | 0.484 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.328312 | 0.484 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.330998 | 0.480 |
| R-HSA-421270 | Cell-cell junction organization | 0.332762 | 0.478 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.334904 | 0.475 |
| R-HSA-70171 | Glycolysis | 0.334904 | 0.475 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.334904 | 0.475 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.335506 | 0.474 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.335506 | 0.474 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.335506 | 0.474 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.338804 | 0.470 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.341286 | 0.467 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.342624 | 0.465 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.342624 | 0.465 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.342624 | 0.465 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.342624 | 0.465 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.342624 | 0.465 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.342624 | 0.465 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.342624 | 0.465 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.342624 | 0.465 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.342624 | 0.465 |
| R-HSA-9733709 | Cardiogenesis | 0.342624 | 0.465 |
| R-HSA-1483255 | PI Metabolism | 0.342697 | 0.465 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.349665 | 0.456 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.349665 | 0.456 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.349665 | 0.456 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.349665 | 0.456 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.349665 | 0.456 |
| R-HSA-189483 | Heme degradation | 0.349665 | 0.456 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.356632 | 0.448 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.356632 | 0.448 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.356632 | 0.448 |
| R-HSA-203615 | eNOS activation | 0.356632 | 0.448 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.356632 | 0.448 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.356632 | 0.448 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.356632 | 0.448 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.356632 | 0.448 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.356632 | 0.448 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.358193 | 0.446 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.363525 | 0.439 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.363525 | 0.439 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.363525 | 0.439 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.363525 | 0.439 |
| R-HSA-169911 | Regulation of Apoptosis | 0.363525 | 0.439 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.363525 | 0.439 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.363525 | 0.439 |
| R-HSA-416476 | G alpha (q) signalling events | 0.364313 | 0.439 |
| R-HSA-211000 | Gene Silencing by RNA | 0.365893 | 0.437 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.369559 | 0.432 |
| R-HSA-3371511 | HSF1 activation | 0.370344 | 0.431 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.370344 | 0.431 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.370344 | 0.431 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.370344 | 0.431 |
| R-HSA-8853659 | RET signaling | 0.370344 | 0.431 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.372601 | 0.429 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.373557 | 0.428 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.377090 | 0.424 |
| R-HSA-4641258 | Degradation of DVL | 0.377090 | 0.424 |
| R-HSA-4641257 | Degradation of AXIN | 0.377090 | 0.424 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.377090 | 0.424 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.377090 | 0.424 |
| R-HSA-202403 | TCR signaling | 0.377376 | 0.423 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.383765 | 0.416 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.383765 | 0.416 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.383765 | 0.416 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.383765 | 0.416 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.390369 | 0.409 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.390369 | 0.409 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.390369 | 0.409 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.390369 | 0.409 |
| R-HSA-69541 | Stabilization of p53 | 0.390369 | 0.409 |
| R-HSA-71336 | Pentose phosphate pathway | 0.390369 | 0.409 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.392551 | 0.406 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.392734 | 0.406 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.396902 | 0.401 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.396902 | 0.401 |
| R-HSA-3371568 | Attenuation phase | 0.396902 | 0.401 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.396902 | 0.401 |
| R-HSA-9646399 | Aggrephagy | 0.396902 | 0.401 |
| R-HSA-202433 | Generation of second messenger molecules | 0.396902 | 0.401 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.396902 | 0.401 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.396902 | 0.401 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.400647 | 0.397 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.401372 | 0.396 |
| R-HSA-9607240 | FLT3 Signaling | 0.403365 | 0.394 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.403365 | 0.394 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.403365 | 0.394 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.403365 | 0.394 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.403365 | 0.394 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.403365 | 0.394 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.403824 | 0.394 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.407879 | 0.389 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.409760 | 0.387 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.409760 | 0.387 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.409760 | 0.387 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.409760 | 0.387 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.409760 | 0.387 |
| R-HSA-70326 | Glucose metabolism | 0.411284 | 0.386 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.411284 | 0.386 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.416087 | 0.381 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.416087 | 0.381 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.416087 | 0.381 |
| R-HSA-73928 | Depyrimidination | 0.416087 | 0.381 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.418544 | 0.378 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.422346 | 0.374 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.422346 | 0.374 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.422346 | 0.374 |
| R-HSA-68875 | Mitotic Prophase | 0.422389 | 0.374 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.423385 | 0.373 |
| R-HSA-3371556 | Cellular response to heat stress | 0.426066 | 0.371 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.428538 | 0.368 |
| R-HSA-9907900 | Proteasome assembly | 0.428538 | 0.368 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.428538 | 0.368 |
| R-HSA-373752 | Netrin-1 signaling | 0.428538 | 0.368 |
| R-HSA-156581 | Methylation | 0.428538 | 0.368 |
| R-HSA-112316 | Neuronal System | 0.429100 | 0.367 |
| R-HSA-72172 | mRNA Splicing | 0.432732 | 0.364 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.434665 | 0.362 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.434665 | 0.362 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.434665 | 0.362 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.434665 | 0.362 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.434665 | 0.362 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.434665 | 0.362 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.438170 | 0.358 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.440726 | 0.356 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.440726 | 0.356 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.440726 | 0.356 |
| R-HSA-194138 | Signaling by VEGF | 0.444270 | 0.352 |
| R-HSA-195721 | Signaling by WNT | 0.446125 | 0.351 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.446722 | 0.350 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.446722 | 0.350 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.446722 | 0.350 |
| R-HSA-69481 | G2/M Checkpoints | 0.451463 | 0.345 |
| R-HSA-70263 | Gluconeogenesis | 0.452655 | 0.344 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.455039 | 0.342 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.457946 | 0.339 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.458524 | 0.339 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.458524 | 0.339 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.464331 | 0.333 |
| R-HSA-109704 | PI3K Cascade | 0.464331 | 0.333 |
| R-HSA-9748787 | Azathioprine ADME | 0.464331 | 0.333 |
| R-HSA-9843745 | Adipogenesis | 0.469211 | 0.329 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.470076 | 0.328 |
| R-HSA-912446 | Meiotic recombination | 0.470076 | 0.328 |
| R-HSA-9864848 | Complex IV assembly | 0.470076 | 0.328 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.470076 | 0.328 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.470076 | 0.328 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.470076 | 0.328 |
| R-HSA-9748784 | Drug ADME | 0.471752 | 0.326 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.475759 | 0.323 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.475759 | 0.323 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.475759 | 0.323 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.475759 | 0.323 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.475759 | 0.323 |
| R-HSA-74160 | Gene expression (Transcription) | 0.477272 | 0.321 |
| R-HSA-1221632 | Meiotic synapsis | 0.481382 | 0.318 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.481382 | 0.318 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.481382 | 0.318 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.481382 | 0.318 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.481382 | 0.318 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.486945 | 0.313 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.486945 | 0.313 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.490055 | 0.310 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.492449 | 0.308 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.496889 | 0.304 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.496889 | 0.304 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.497894 | 0.303 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.497894 | 0.303 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.503281 | 0.298 |
| R-HSA-112399 | IRS-mediated signalling | 0.503281 | 0.298 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.504248 | 0.297 |
| R-HSA-1632852 | Macroautophagy | 0.507030 | 0.295 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.508610 | 0.294 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.508610 | 0.294 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.508610 | 0.294 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.508610 | 0.294 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.513718 | 0.289 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.513883 | 0.289 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.516922 | 0.287 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.517039 | 0.286 |
| R-HSA-983189 | Kinesins | 0.519099 | 0.285 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.519099 | 0.285 |
| R-HSA-351202 | Metabolism of polyamines | 0.519099 | 0.285 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.524260 | 0.280 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.524260 | 0.280 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.524260 | 0.280 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.524260 | 0.280 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.529365 | 0.276 |
| R-HSA-1268020 | Mitochondrial protein import | 0.529365 | 0.276 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.529365 | 0.276 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.529365 | 0.276 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.534416 | 0.272 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.534416 | 0.272 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.534416 | 0.272 |
| R-HSA-9758941 | Gastrulation | 0.536652 | 0.270 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.539414 | 0.268 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.539414 | 0.268 |
| R-HSA-449147 | Signaling by Interleukins | 0.544239 | 0.264 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.544358 | 0.264 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.544358 | 0.264 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.546252 | 0.263 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.546252 | 0.263 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.548403 | 0.261 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.549249 | 0.260 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.549249 | 0.260 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.549249 | 0.260 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.554088 | 0.256 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.555714 | 0.255 |
| R-HSA-9612973 | Autophagy | 0.558837 | 0.253 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.558875 | 0.253 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.561728 | 0.250 |
| R-HSA-162587 | HIV Life Cycle | 0.561944 | 0.250 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.568297 | 0.245 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.568297 | 0.245 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.568297 | 0.245 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.568297 | 0.245 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.572932 | 0.242 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.572932 | 0.242 |
| R-HSA-8978934 | Metabolism of cofactors | 0.572932 | 0.242 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.572932 | 0.242 |
| R-HSA-189445 | Metabolism of porphyrins | 0.572932 | 0.242 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.577518 | 0.238 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.577518 | 0.238 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.577518 | 0.238 |
| R-HSA-74259 | Purine catabolism | 0.577518 | 0.238 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.582055 | 0.235 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.582055 | 0.235 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.582055 | 0.235 |
| R-HSA-4086398 | Ca2+ pathway | 0.582055 | 0.235 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.582055 | 0.235 |
| R-HSA-9749641 | Aspirin ADME | 0.582055 | 0.235 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.586544 | 0.232 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.586544 | 0.232 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.586544 | 0.232 |
| R-HSA-380287 | Centrosome maturation | 0.590985 | 0.228 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.590985 | 0.228 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.590985 | 0.228 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.590985 | 0.228 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.599725 | 0.222 |
| R-HSA-72306 | tRNA processing | 0.603806 | 0.219 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.604025 | 0.219 |
| R-HSA-216083 | Integrin cell surface interactions | 0.604025 | 0.219 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.604025 | 0.219 |
| R-HSA-4086400 | PCP/CE pathway | 0.604025 | 0.219 |
| R-HSA-418555 | G alpha (s) signalling events | 0.606678 | 0.217 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.606678 | 0.217 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.608279 | 0.216 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.608279 | 0.216 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.609535 | 0.215 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.612487 | 0.213 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.616651 | 0.210 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.616651 | 0.210 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.618011 | 0.209 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.620770 | 0.207 |
| R-HSA-611105 | Respiratory electron transport | 0.626346 | 0.203 |
| R-HSA-212436 | Generic Transcription Pathway | 0.628416 | 0.202 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.628877 | 0.201 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.628877 | 0.201 |
| R-HSA-2559583 | Cellular Senescence | 0.631824 | 0.199 |
| R-HSA-1500620 | Meiosis | 0.632865 | 0.199 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.632865 | 0.199 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.634351 | 0.198 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.636811 | 0.196 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.640715 | 0.193 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.640715 | 0.193 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.646426 | 0.189 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.647061 | 0.189 |
| R-HSA-69275 | G2/M Transition | 0.647885 | 0.189 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.648398 | 0.188 |
| R-HSA-9663891 | Selective autophagy | 0.648398 | 0.188 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.652178 | 0.186 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.653115 | 0.185 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.655917 | 0.183 |
| R-HSA-202424 | Downstream TCR signaling | 0.655917 | 0.183 |
| R-HSA-1483257 | Phospholipid metabolism | 0.659848 | 0.181 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.661946 | 0.179 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.663391 | 0.178 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.666898 | 0.176 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.666898 | 0.176 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.673168 | 0.172 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.674024 | 0.171 |
| R-HSA-1474290 | Collagen formation | 0.674024 | 0.171 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.677530 | 0.169 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.683210 | 0.165 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.684430 | 0.165 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.684430 | 0.165 |
| R-HSA-157579 | Telomere Maintenance | 0.687824 | 0.163 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.690393 | 0.161 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.694505 | 0.158 |
| R-HSA-211859 | Biological oxidations | 0.698037 | 0.156 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.701044 | 0.154 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.704261 | 0.152 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.707443 | 0.150 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.709529 | 0.149 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.710592 | 0.148 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.710592 | 0.148 |
| R-HSA-397014 | Muscle contraction | 0.713381 | 0.147 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.713706 | 0.146 |
| R-HSA-9833110 | RSV-host interactions | 0.713706 | 0.146 |
| R-HSA-8957322 | Metabolism of steroids | 0.716942 | 0.145 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.719836 | 0.143 |
| R-HSA-69239 | Synthesis of DNA | 0.722852 | 0.141 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.722852 | 0.141 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.722852 | 0.141 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.725836 | 0.139 |
| R-HSA-162582 | Signal Transduction | 0.732235 | 0.135 |
| R-HSA-6803157 | Antimicrobial peptides | 0.734596 | 0.134 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.737454 | 0.132 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.737454 | 0.132 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.737454 | 0.132 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.743078 | 0.129 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.743158 | 0.129 |
| R-HSA-9679506 | SARS-CoV Infections | 0.744337 | 0.128 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.751291 | 0.124 |
| R-HSA-388396 | GPCR downstream signalling | 0.754930 | 0.122 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.756621 | 0.121 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.756766 | 0.121 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.758964 | 0.120 |
| R-HSA-5693538 | Homology Directed Repair | 0.759243 | 0.120 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.759243 | 0.120 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.761836 | 0.118 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.766941 | 0.115 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.771937 | 0.112 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.771937 | 0.112 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.774395 | 0.111 |
| R-HSA-69206 | G1/S Transition | 0.779232 | 0.108 |
| R-HSA-4839726 | Chromatin organization | 0.786353 | 0.104 |
| R-HSA-8956319 | Nucleotide catabolism | 0.788599 | 0.103 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.790879 | 0.102 |
| R-HSA-1474165 | Reproduction | 0.793133 | 0.101 |
| R-HSA-9824446 | Viral Infection Pathways | 0.795366 | 0.099 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.797571 | 0.098 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.798177 | 0.098 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.808255 | 0.092 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.809422 | 0.092 |
| R-HSA-913531 | Interferon Signaling | 0.811284 | 0.091 |
| R-HSA-5368287 | Mitochondrial translation | 0.812370 | 0.090 |
| R-HSA-6807070 | PTEN Regulation | 0.814395 | 0.089 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.818378 | 0.087 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.824195 | 0.084 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.825376 | 0.083 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.826093 | 0.083 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.829061 | 0.081 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.829827 | 0.081 |
| R-HSA-69242 | S Phase | 0.833482 | 0.079 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.837058 | 0.077 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.837058 | 0.077 |
| R-HSA-372790 | Signaling by GPCR | 0.837324 | 0.077 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.840558 | 0.075 |
| R-HSA-9609507 | Protein localization | 0.842280 | 0.075 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.843984 | 0.074 |
| R-HSA-73887 | Death Receptor Signaling | 0.843984 | 0.074 |
| R-HSA-9610379 | HCMV Late Events | 0.848985 | 0.071 |
| R-HSA-9711097 | Cellular response to starvation | 0.850616 | 0.070 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.850616 | 0.070 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.853827 | 0.069 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.854038 | 0.069 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.860043 | 0.065 |
| R-HSA-72766 | Translation | 0.864406 | 0.063 |
| R-HSA-5619102 | SLC transporter disorders | 0.864532 | 0.063 |
| R-HSA-168256 | Immune System | 0.866873 | 0.062 |
| R-HSA-109582 | Hemostasis | 0.867778 | 0.062 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.875816 | 0.058 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.877159 | 0.057 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.888254 | 0.051 |
| R-HSA-1280218 | Adaptive Immune System | 0.892440 | 0.049 |
| R-HSA-5617833 | Cilium Assembly | 0.895655 | 0.048 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.901688 | 0.045 |
| R-HSA-9609690 | HCMV Early Events | 0.902253 | 0.045 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.902542 | 0.045 |
| R-HSA-428157 | Sphingolipid metabolism | 0.907434 | 0.042 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.909428 | 0.041 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.909428 | 0.041 |
| R-HSA-6805567 | Keratinization | 0.913291 | 0.039 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.918966 | 0.037 |
| R-HSA-15869 | Metabolism of nucleotides | 0.937488 | 0.028 |
| R-HSA-8939211 | ESR-mediated signaling | 0.938166 | 0.028 |
| R-HSA-157118 | Signaling by NOTCH | 0.940159 | 0.027 |
| R-HSA-9609646 | HCMV Infection | 0.946351 | 0.024 |
| R-HSA-500792 | GPCR ligand binding | 0.961258 | 0.017 |
| R-HSA-556833 | Metabolism of lipids | 0.967492 | 0.014 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.975882 | 0.011 |
| R-HSA-5663205 | Infectious disease | 0.980459 | 0.009 |
| R-HSA-1643685 | Disease | 0.982294 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.984631 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.984739 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.990537 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 0.992412 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.992606 | 0.003 |
| R-HSA-1430728 | Metabolism | 0.999686 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999988 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.841 | 0.507 | 2 | 0.894 |
COT |
0.816 | 0.093 | 2 | 0.692 |
CLK3 |
0.810 | 0.129 | 1 | 0.858 |
CAMK2G |
0.801 | 0.152 | 2 | 0.688 |
DSTYK |
0.801 | 0.083 | 2 | 0.735 |
PIM3 |
0.800 | 0.059 | -3 | 0.842 |
CAMK2B |
0.798 | 0.221 | 2 | 0.717 |
IKKB |
0.798 | 0.061 | -2 | 0.741 |
PRPK |
0.796 | -0.023 | -1 | 0.862 |
MOS |
0.796 | 0.031 | 1 | 0.830 |
ERK5 |
0.796 | 0.058 | 1 | 0.882 |
IKKA |
0.795 | 0.141 | -2 | 0.735 |
CDC7 |
0.795 | -0.022 | 1 | 0.795 |
CK2A2 |
0.795 | 0.444 | 1 | 0.615 |
SRPK1 |
0.794 | 0.047 | -3 | 0.750 |
GCN2 |
0.794 | -0.118 | 2 | 0.596 |
GRK6 |
0.794 | 0.238 | 1 | 0.765 |
NLK |
0.794 | 0.004 | 1 | 0.858 |
BMPR2 |
0.793 | 0.012 | -2 | 0.901 |
MTOR |
0.793 | -0.041 | 1 | 0.814 |
TBK1 |
0.792 | -0.049 | 1 | 0.697 |
NDR2 |
0.791 | -0.006 | -3 | 0.846 |
NEK6 |
0.791 | -0.035 | -2 | 0.906 |
TGFBR1 |
0.791 | 0.207 | -2 | 0.875 |
PIM1 |
0.791 | 0.070 | -3 | 0.789 |
PKN3 |
0.791 | 0.004 | -3 | 0.833 |
CAMK1B |
0.791 | -0.002 | -3 | 0.856 |
TGFBR2 |
0.791 | 0.008 | -2 | 0.884 |
ATM |
0.791 | 0.111 | 1 | 0.776 |
PDHK4 |
0.791 | -0.051 | 1 | 0.819 |
ATR |
0.790 | 0.038 | 1 | 0.828 |
PRKD1 |
0.790 | 0.005 | -3 | 0.838 |
BMPR1B |
0.790 | 0.174 | 1 | 0.727 |
RAF1 |
0.790 | -0.107 | 1 | 0.790 |
RSK2 |
0.790 | 0.049 | -3 | 0.772 |
ULK2 |
0.789 | -0.110 | 2 | 0.589 |
PLK3 |
0.789 | 0.195 | 2 | 0.624 |
GRK7 |
0.789 | 0.276 | 1 | 0.728 |
CDKL1 |
0.789 | 0.003 | -3 | 0.803 |
IKKE |
0.789 | -0.053 | 1 | 0.686 |
GRK1 |
0.789 | 0.133 | -2 | 0.727 |
SRPK2 |
0.788 | 0.040 | -3 | 0.677 |
ALK2 |
0.787 | 0.234 | -2 | 0.879 |
GRK5 |
0.787 | 0.060 | -3 | 0.855 |
MAPKAPK2 |
0.787 | 0.108 | -3 | 0.748 |
CAMK2A |
0.787 | 0.129 | 2 | 0.687 |
CDKL5 |
0.786 | 0.006 | -3 | 0.799 |
CAMK2D |
0.785 | 0.072 | -3 | 0.842 |
NEK7 |
0.785 | -0.100 | -3 | 0.817 |
KIS |
0.785 | 0.033 | 1 | 0.787 |
P90RSK |
0.784 | 0.010 | -3 | 0.778 |
SKMLCK |
0.784 | -0.002 | -2 | 0.813 |
LATS2 |
0.784 | 0.024 | -5 | 0.711 |
SRPK3 |
0.784 | 0.024 | -3 | 0.719 |
HUNK |
0.783 | -0.073 | 2 | 0.592 |
PLK1 |
0.783 | 0.111 | -2 | 0.885 |
PDHK1 |
0.783 | -0.111 | 1 | 0.804 |
RIPK3 |
0.783 | -0.150 | 3 | 0.319 |
CAMLCK |
0.782 | -0.029 | -2 | 0.828 |
ALK4 |
0.782 | 0.128 | -2 | 0.892 |
MARK4 |
0.782 | -0.018 | 4 | 0.849 |
GRK4 |
0.782 | 0.028 | -2 | 0.815 |
MLK1 |
0.782 | -0.092 | 2 | 0.637 |
NIK |
0.782 | -0.092 | -3 | 0.877 |
CK2A1 |
0.782 | 0.401 | 1 | 0.587 |
NUAK2 |
0.781 | -0.052 | -3 | 0.836 |
PRKD2 |
0.781 | -0.012 | -3 | 0.781 |
PKCD |
0.781 | -0.030 | 2 | 0.617 |
CDK8 |
0.781 | 0.055 | 1 | 0.751 |
NDR1 |
0.781 | -0.063 | -3 | 0.837 |
DNAPK |
0.781 | 0.114 | 1 | 0.734 |
WNK1 |
0.780 | -0.081 | -2 | 0.822 |
TSSK2 |
0.780 | 0.000 | -5 | 0.791 |
MST4 |
0.780 | -0.073 | 2 | 0.664 |
LATS1 |
0.780 | 0.119 | -3 | 0.853 |
ACVR2A |
0.779 | 0.135 | -2 | 0.880 |
MAPKAPK3 |
0.779 | 0.020 | -3 | 0.785 |
BCKDK |
0.779 | -0.052 | -1 | 0.805 |
ICK |
0.779 | 0.001 | -3 | 0.840 |
RSK3 |
0.779 | -0.025 | -3 | 0.767 |
HIPK4 |
0.778 | -0.020 | 1 | 0.823 |
BMPR1A |
0.778 | 0.171 | 1 | 0.707 |
ULK1 |
0.778 | -0.122 | -3 | 0.821 |
DAPK2 |
0.777 | -0.058 | -3 | 0.860 |
CLK2 |
0.777 | 0.084 | -3 | 0.750 |
JNK3 |
0.777 | 0.112 | 1 | 0.743 |
IRE2 |
0.776 | -0.098 | 2 | 0.573 |
ACVR2B |
0.776 | 0.112 | -2 | 0.883 |
DYRK2 |
0.776 | 0.062 | 1 | 0.774 |
AMPKA1 |
0.775 | -0.045 | -3 | 0.855 |
WNK3 |
0.775 | -0.181 | 1 | 0.785 |
CDK5 |
0.775 | 0.035 | 1 | 0.775 |
CDK1 |
0.775 | 0.055 | 1 | 0.705 |
MLK3 |
0.774 | -0.062 | 2 | 0.585 |
P70S6KB |
0.774 | -0.032 | -3 | 0.794 |
TSSK1 |
0.774 | -0.032 | -3 | 0.875 |
ANKRD3 |
0.774 | -0.144 | 1 | 0.815 |
PKN2 |
0.774 | -0.093 | -3 | 0.833 |
RSK4 |
0.774 | 0.046 | -3 | 0.747 |
DLK |
0.774 | -0.094 | 1 | 0.781 |
TTBK2 |
0.774 | -0.071 | 2 | 0.505 |
NIM1 |
0.774 | -0.103 | 3 | 0.353 |
JNK2 |
0.773 | 0.103 | 1 | 0.709 |
MASTL |
0.773 | -0.182 | -2 | 0.788 |
P38A |
0.773 | 0.061 | 1 | 0.804 |
CLK4 |
0.773 | 0.031 | -3 | 0.762 |
CDK19 |
0.773 | 0.041 | 1 | 0.721 |
MSK2 |
0.772 | -0.004 | -3 | 0.744 |
NEK9 |
0.772 | -0.171 | 2 | 0.627 |
PKACG |
0.771 | -0.028 | -2 | 0.720 |
CDK7 |
0.771 | 0.021 | 1 | 0.761 |
P38B |
0.771 | 0.085 | 1 | 0.745 |
IRE1 |
0.771 | -0.151 | 1 | 0.769 |
MLK4 |
0.770 | -0.059 | 2 | 0.563 |
CLK1 |
0.770 | 0.020 | -3 | 0.738 |
PKR |
0.770 | -0.070 | 1 | 0.798 |
TLK2 |
0.770 | 0.024 | 1 | 0.751 |
AMPKA2 |
0.770 | -0.051 | -3 | 0.824 |
CDK3 |
0.769 | 0.049 | 1 | 0.664 |
ERK1 |
0.769 | 0.056 | 1 | 0.738 |
CDK13 |
0.769 | 0.027 | 1 | 0.740 |
CDK2 |
0.769 | -0.009 | 1 | 0.757 |
CHAK2 |
0.769 | -0.151 | -1 | 0.842 |
CDK18 |
0.768 | 0.041 | 1 | 0.702 |
MLK2 |
0.768 | -0.171 | 2 | 0.619 |
NUAK1 |
0.768 | -0.074 | -3 | 0.787 |
CHK1 |
0.768 | -0.008 | -3 | 0.847 |
P38G |
0.768 | 0.081 | 1 | 0.643 |
CAMK4 |
0.768 | -0.087 | -3 | 0.820 |
PKCB |
0.768 | -0.058 | 2 | 0.578 |
ERK2 |
0.768 | 0.043 | 1 | 0.764 |
RIPK1 |
0.768 | -0.190 | 1 | 0.777 |
PAK1 |
0.767 | -0.036 | -2 | 0.740 |
PKCA |
0.767 | -0.056 | 2 | 0.571 |
MSK1 |
0.767 | 0.018 | -3 | 0.751 |
PLK2 |
0.767 | 0.130 | -3 | 0.810 |
AURC |
0.767 | -0.027 | -2 | 0.639 |
PKCG |
0.766 | -0.063 | 2 | 0.571 |
PRKD3 |
0.765 | -0.044 | -3 | 0.735 |
SMG1 |
0.765 | -0.012 | 1 | 0.793 |
PKACB |
0.764 | 0.014 | -2 | 0.665 |
PIM2 |
0.764 | 0.004 | -3 | 0.744 |
DYRK4 |
0.764 | 0.081 | 1 | 0.717 |
PHKG1 |
0.764 | -0.109 | -3 | 0.828 |
MARK2 |
0.764 | -0.013 | 4 | 0.754 |
CDK17 |
0.764 | 0.042 | 1 | 0.645 |
PLK4 |
0.763 | -0.070 | 2 | 0.432 |
MELK |
0.763 | -0.102 | -3 | 0.806 |
VRK2 |
0.763 | -0.221 | 1 | 0.853 |
PKCH |
0.763 | -0.078 | 2 | 0.562 |
YSK4 |
0.763 | -0.118 | 1 | 0.737 |
MEK1 |
0.763 | -0.134 | 2 | 0.632 |
PAK3 |
0.763 | -0.093 | -2 | 0.742 |
CDK16 |
0.763 | 0.062 | 1 | 0.664 |
MYLK4 |
0.763 | -0.036 | -2 | 0.737 |
BRSK1 |
0.762 | -0.048 | -3 | 0.788 |
QSK |
0.762 | -0.061 | 4 | 0.833 |
HIPK2 |
0.762 | 0.053 | 1 | 0.705 |
CDK12 |
0.762 | 0.029 | 1 | 0.716 |
MNK2 |
0.762 | -0.079 | -2 | 0.768 |
MARK3 |
0.762 | -0.025 | 4 | 0.802 |
PRKX |
0.762 | 0.043 | -3 | 0.677 |
P38D |
0.761 | 0.088 | 1 | 0.692 |
PRP4 |
0.761 | 0.028 | -3 | 0.785 |
HRI |
0.761 | -0.123 | -2 | 0.894 |
MNK1 |
0.761 | -0.067 | -2 | 0.775 |
AURA |
0.761 | -0.008 | -2 | 0.616 |
CDK9 |
0.761 | 0.010 | 1 | 0.750 |
ERK7 |
0.761 | 0.011 | 2 | 0.437 |
PERK |
0.761 | -0.093 | -2 | 0.873 |
DRAK1 |
0.760 | -0.065 | 1 | 0.689 |
HIPK1 |
0.760 | 0.033 | 1 | 0.789 |
AURB |
0.760 | -0.038 | -2 | 0.641 |
BRAF |
0.760 | -0.038 | -4 | 0.846 |
SIK |
0.759 | -0.070 | -3 | 0.760 |
PKG2 |
0.759 | -0.031 | -2 | 0.662 |
NEK2 |
0.759 | -0.122 | 2 | 0.601 |
GRK2 |
0.759 | -0.011 | -2 | 0.723 |
PAK2 |
0.759 | -0.072 | -2 | 0.728 |
MAPKAPK5 |
0.759 | -0.064 | -3 | 0.721 |
PKCZ |
0.758 | -0.116 | 2 | 0.589 |
TLK1 |
0.758 | -0.039 | -2 | 0.878 |
QIK |
0.758 | -0.138 | -3 | 0.822 |
PAK6 |
0.758 | -0.034 | -2 | 0.675 |
JNK1 |
0.758 | 0.086 | 1 | 0.686 |
MARK1 |
0.758 | -0.039 | 4 | 0.825 |
DYRK1A |
0.758 | 0.017 | 1 | 0.810 |
DYRK1B |
0.757 | 0.060 | 1 | 0.732 |
CDK14 |
0.757 | 0.028 | 1 | 0.730 |
PASK |
0.757 | 0.006 | -3 | 0.851 |
GSK3A |
0.756 | 0.042 | 4 | 0.402 |
DCAMKL1 |
0.756 | -0.048 | -3 | 0.786 |
SGK3 |
0.756 | -0.027 | -3 | 0.757 |
MEKK1 |
0.756 | -0.161 | 1 | 0.779 |
CAMK1G |
0.756 | -0.060 | -3 | 0.757 |
BRSK2 |
0.756 | -0.105 | -3 | 0.811 |
AKT2 |
0.755 | -0.023 | -3 | 0.683 |
SSTK |
0.754 | -0.044 | 4 | 0.824 |
CHAK1 |
0.754 | -0.206 | 2 | 0.541 |
SNRK |
0.754 | -0.190 | 2 | 0.487 |
MEKK2 |
0.754 | -0.136 | 2 | 0.607 |
HIPK3 |
0.753 | -0.003 | 1 | 0.796 |
PINK1 |
0.753 | -0.115 | 1 | 0.822 |
PHKG2 |
0.753 | -0.100 | -3 | 0.791 |
MEKK3 |
0.753 | -0.142 | 1 | 0.761 |
ZAK |
0.753 | -0.147 | 1 | 0.749 |
NEK5 |
0.752 | -0.156 | 1 | 0.809 |
WNK4 |
0.752 | -0.140 | -2 | 0.820 |
IRAK4 |
0.752 | -0.171 | 1 | 0.782 |
DYRK3 |
0.751 | 0.026 | 1 | 0.786 |
PKCT |
0.751 | -0.088 | 2 | 0.565 |
CAMK1D |
0.751 | 0.008 | -3 | 0.676 |
GAK |
0.751 | 0.019 | 1 | 0.829 |
CDK10 |
0.750 | 0.029 | 1 | 0.719 |
SMMLCK |
0.750 | -0.061 | -3 | 0.811 |
MEK5 |
0.750 | -0.246 | 2 | 0.620 |
DCAMKL2 |
0.750 | -0.072 | -3 | 0.805 |
TAO3 |
0.749 | -0.097 | 1 | 0.765 |
TTBK1 |
0.749 | -0.095 | 2 | 0.445 |
GRK3 |
0.749 | 0.020 | -2 | 0.680 |
PKACA |
0.749 | 0.000 | -2 | 0.616 |
IRAK1 |
0.748 | -0.164 | -1 | 0.761 |
CDK6 |
0.747 | 0.019 | 1 | 0.726 |
NEK8 |
0.746 | -0.154 | 2 | 0.618 |
GSK3B |
0.746 | -0.031 | 4 | 0.394 |
MST3 |
0.746 | -0.130 | 2 | 0.631 |
AKT1 |
0.745 | -0.030 | -3 | 0.702 |
CAMKK1 |
0.745 | -0.101 | -2 | 0.753 |
EEF2K |
0.745 | -0.072 | 3 | 0.369 |
TAO2 |
0.745 | -0.124 | 2 | 0.658 |
CK1E |
0.744 | -0.051 | -3 | 0.552 |
DAPK3 |
0.744 | -0.019 | -3 | 0.796 |
CDK4 |
0.744 | 0.025 | 1 | 0.701 |
P70S6K |
0.743 | -0.068 | -3 | 0.703 |
MAK |
0.741 | 0.044 | -2 | 0.665 |
MPSK1 |
0.740 | -0.087 | 1 | 0.786 |
PKCE |
0.740 | -0.064 | 2 | 0.562 |
PKCI |
0.740 | -0.112 | 2 | 0.571 |
MST2 |
0.740 | -0.098 | 1 | 0.756 |
CAMKK2 |
0.740 | -0.101 | -2 | 0.741 |
CK1D |
0.739 | -0.032 | -3 | 0.500 |
PDK1 |
0.738 | -0.114 | 1 | 0.775 |
PAK5 |
0.738 | -0.062 | -2 | 0.610 |
CK1G1 |
0.737 | -0.076 | -3 | 0.530 |
PKN1 |
0.737 | -0.073 | -3 | 0.718 |
SBK |
0.737 | 0.034 | -3 | 0.571 |
TTK |
0.737 | -0.019 | -2 | 0.887 |
TNIK |
0.736 | -0.105 | 3 | 0.347 |
PAK4 |
0.736 | -0.060 | -2 | 0.618 |
NEK11 |
0.736 | -0.226 | 1 | 0.753 |
MOK |
0.736 | 0.023 | 1 | 0.811 |
PDHK3_TYR |
0.735 | 0.156 | 4 | 0.881 |
TAK1 |
0.735 | -0.111 | 1 | 0.772 |
DAPK1 |
0.735 | -0.030 | -3 | 0.775 |
LKB1 |
0.735 | -0.141 | -3 | 0.828 |
GCK |
0.735 | -0.125 | 1 | 0.736 |
MEKK6 |
0.734 | -0.196 | 1 | 0.791 |
SGK1 |
0.734 | 0.002 | -3 | 0.609 |
HGK |
0.734 | -0.145 | 3 | 0.343 |
CK1A2 |
0.734 | -0.051 | -3 | 0.498 |
VRK1 |
0.734 | -0.182 | 2 | 0.627 |
NEK4 |
0.734 | -0.209 | 1 | 0.758 |
AKT3 |
0.734 | -0.024 | -3 | 0.626 |
CAMK1A |
0.733 | -0.035 | -3 | 0.652 |
MAP3K15 |
0.733 | -0.183 | 1 | 0.752 |
MINK |
0.732 | -0.143 | 1 | 0.745 |
MST1 |
0.732 | -0.122 | 1 | 0.738 |
BUB1 |
0.732 | -0.048 | -5 | 0.722 |
MRCKB |
0.732 | -0.036 | -3 | 0.732 |
CHK2 |
0.731 | -0.057 | -3 | 0.632 |
PDHK4_TYR |
0.731 | 0.148 | 2 | 0.688 |
RIPK2 |
0.730 | -0.209 | 1 | 0.710 |
LRRK2 |
0.730 | -0.193 | 2 | 0.640 |
NEK1 |
0.730 | -0.190 | 1 | 0.778 |
ROCK2 |
0.729 | -0.041 | -3 | 0.786 |
MAP2K6_TYR |
0.727 | 0.101 | -1 | 0.870 |
MRCKA |
0.727 | -0.051 | -3 | 0.749 |
LOK |
0.727 | -0.157 | -2 | 0.745 |
KHS1 |
0.727 | -0.121 | 1 | 0.732 |
DMPK1 |
0.727 | -0.013 | -3 | 0.752 |
TESK1_TYR |
0.726 | -0.047 | 3 | 0.415 |
BIKE |
0.725 | 0.017 | 1 | 0.737 |
YES1 |
0.725 | 0.033 | -1 | 0.897 |
YSK1 |
0.725 | -0.156 | 2 | 0.611 |
PDHK1_TYR |
0.725 | 0.082 | -1 | 0.898 |
KHS2 |
0.724 | -0.105 | 1 | 0.733 |
MAP2K7_TYR |
0.724 | -0.004 | 2 | 0.664 |
MAP2K4_TYR |
0.724 | 0.005 | -1 | 0.869 |
HPK1 |
0.724 | -0.151 | 1 | 0.721 |
OSR1 |
0.724 | -0.098 | 2 | 0.589 |
PBK |
0.723 | -0.055 | 1 | 0.786 |
ALPHAK3 |
0.723 | 0.043 | -1 | 0.768 |
MEK2 |
0.723 | -0.219 | 2 | 0.590 |
PKMYT1_TYR |
0.723 | -0.114 | 3 | 0.391 |
SLK |
0.723 | -0.134 | -2 | 0.687 |
STK33 |
0.723 | -0.174 | 2 | 0.442 |
PKG1 |
0.722 | -0.056 | -2 | 0.590 |
BMPR2_TYR |
0.722 | 0.026 | -1 | 0.858 |
EPHA6 |
0.722 | -0.017 | -1 | 0.878 |
PINK1_TYR |
0.721 | -0.088 | 1 | 0.813 |
YANK3 |
0.721 | -0.064 | 2 | 0.297 |
RET |
0.720 | -0.076 | 1 | 0.788 |
EPHB4 |
0.719 | -0.043 | -1 | 0.870 |
BLK |
0.719 | 0.031 | -1 | 0.882 |
NEK3 |
0.718 | -0.205 | 1 | 0.766 |
ABL2 |
0.718 | -0.034 | -1 | 0.842 |
INSRR |
0.718 | -0.030 | 3 | 0.328 |
TXK |
0.717 | 0.015 | 1 | 0.764 |
LIMK2_TYR |
0.716 | -0.105 | -3 | 0.893 |
CRIK |
0.716 | -0.034 | -3 | 0.708 |
LCK |
0.716 | -0.005 | -1 | 0.870 |
FGR |
0.716 | -0.049 | 1 | 0.818 |
EPHA4 |
0.716 | 0.012 | 2 | 0.633 |
ROCK1 |
0.716 | -0.054 | -3 | 0.751 |
TYRO3 |
0.716 | -0.145 | 3 | 0.323 |
HCK |
0.716 | -0.032 | -1 | 0.865 |
FER |
0.715 | -0.028 | 1 | 0.826 |
CSF1R |
0.715 | -0.112 | 3 | 0.322 |
FYN |
0.715 | 0.056 | -1 | 0.854 |
ASK1 |
0.714 | -0.147 | 1 | 0.741 |
ROS1 |
0.714 | -0.175 | 3 | 0.301 |
DDR1 |
0.714 | -0.072 | 4 | 0.822 |
TYK2 |
0.713 | -0.175 | 1 | 0.789 |
FGFR2 |
0.713 | -0.057 | 3 | 0.368 |
HASPIN |
0.713 | -0.075 | -1 | 0.700 |
SRMS |
0.713 | -0.000 | 1 | 0.792 |
MST1R |
0.713 | -0.192 | 3 | 0.339 |
JAK2 |
0.712 | -0.168 | 1 | 0.794 |
ABL1 |
0.712 | -0.069 | -1 | 0.836 |
AAK1 |
0.712 | 0.037 | 1 | 0.659 |
EPHB2 |
0.712 | -0.015 | -1 | 0.857 |
LIMK1_TYR |
0.712 | -0.166 | 2 | 0.656 |
MYO3B |
0.711 | -0.149 | 2 | 0.618 |
TAO1 |
0.711 | -0.148 | 1 | 0.709 |
EPHB3 |
0.711 | -0.046 | -1 | 0.864 |
ITK |
0.710 | -0.062 | -1 | 0.824 |
JAK3 |
0.710 | -0.116 | 1 | 0.781 |
TNK2 |
0.709 | -0.117 | 3 | 0.322 |
EPHB1 |
0.709 | -0.069 | 1 | 0.803 |
LYN |
0.709 | -0.013 | 3 | 0.312 |
FGFR1 |
0.708 | -0.105 | 3 | 0.345 |
MYO3A |
0.708 | -0.162 | 1 | 0.730 |
KDR |
0.707 | -0.129 | 3 | 0.319 |
MERTK |
0.707 | -0.070 | 3 | 0.350 |
TEK |
0.707 | -0.122 | 3 | 0.312 |
KIT |
0.707 | -0.107 | 3 | 0.334 |
TEC |
0.706 | -0.049 | -1 | 0.782 |
PDGFRB |
0.706 | -0.150 | 3 | 0.328 |
FLT3 |
0.706 | -0.132 | 3 | 0.323 |
EPHA7 |
0.706 | -0.040 | 2 | 0.624 |
LTK |
0.705 | -0.095 | 3 | 0.318 |
DDR2 |
0.704 | -0.029 | 3 | 0.320 |
AXL |
0.704 | -0.123 | 3 | 0.338 |
STLK3 |
0.704 | -0.131 | 1 | 0.709 |
TNK1 |
0.703 | -0.144 | 3 | 0.322 |
SRC |
0.703 | -0.009 | -1 | 0.863 |
EPHA5 |
0.703 | -0.002 | 2 | 0.632 |
FGFR3 |
0.703 | -0.074 | 3 | 0.358 |
ALK |
0.702 | -0.135 | 3 | 0.298 |
BMX |
0.702 | -0.056 | -1 | 0.757 |
TNNI3K_TYR |
0.702 | -0.108 | 1 | 0.806 |
EPHA3 |
0.702 | -0.072 | 2 | 0.598 |
NEK10_TYR |
0.701 | -0.094 | 1 | 0.684 |
INSR |
0.701 | -0.096 | 3 | 0.309 |
MET |
0.700 | -0.120 | 3 | 0.330 |
JAK1 |
0.700 | -0.156 | 1 | 0.739 |
BTK |
0.700 | -0.119 | -1 | 0.792 |
EPHA1 |
0.699 | -0.118 | 3 | 0.317 |
NTRK1 |
0.699 | -0.115 | -1 | 0.833 |
PTK2B |
0.699 | -0.057 | -1 | 0.830 |
FRK |
0.698 | -0.107 | -1 | 0.877 |
FLT1 |
0.698 | -0.085 | -1 | 0.833 |
EPHA8 |
0.698 | -0.043 | -1 | 0.849 |
ERBB2 |
0.697 | -0.108 | 1 | 0.720 |
FLT4 |
0.696 | -0.140 | 3 | 0.337 |
NTRK2 |
0.696 | -0.152 | 3 | 0.331 |
CK1A |
0.696 | -0.066 | -3 | 0.407 |
EGFR |
0.695 | 0.002 | 1 | 0.633 |
PTK6 |
0.695 | -0.116 | -1 | 0.760 |
PDGFRA |
0.694 | -0.231 | 3 | 0.318 |
FGFR4 |
0.693 | -0.031 | -1 | 0.795 |
NTRK3 |
0.693 | -0.100 | -1 | 0.795 |
CSK |
0.691 | -0.086 | 2 | 0.613 |
WEE1_TYR |
0.691 | -0.134 | -1 | 0.758 |
IGF1R |
0.690 | -0.079 | 3 | 0.299 |
YANK2 |
0.689 | -0.078 | 2 | 0.329 |
CK1G3 |
0.688 | -0.044 | -3 | 0.355 |
MATK |
0.688 | -0.100 | -1 | 0.773 |
PTK2 |
0.686 | -0.017 | -1 | 0.774 |
EPHA2 |
0.685 | -0.059 | -1 | 0.796 |
SYK |
0.682 | 0.000 | -1 | 0.780 |
ERBB4 |
0.682 | -0.043 | 1 | 0.624 |
MUSK |
0.674 | -0.158 | 1 | 0.634 |
CK1G2 |
0.670 | -0.065 | -3 | 0.449 |
FES |
0.669 | -0.121 | -1 | 0.740 |
ZAP70 |
0.654 | -0.081 | -1 | 0.697 |