Motif 554 (n=218)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0PK00 | TMEM120B | S69 | ochoa | Transmembrane protein 120B | Necessary for efficient adipogenesis. Does not show ion channel activity. {ECO:0000250|UniProtKB:Q3TA38}. |
| A2RU67 | FAM234B | S62 | ochoa | Protein FAM234B | None |
| A4QPH2 | PI4KAP2 | S293 | ochoa | Putative phosphatidylinositol 4-kinase alpha-like protein P2 | None |
| A6NHR9 | SMCHD1 | S293 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A6NKT7 | RGPD3 | Y1028 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1322 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H0YIS7 | RNASEK-C17orf49 | S187 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| I3L4J1 | None | S121 | ochoa | vesicle-fusing ATPase (EC 3.6.4.6) | (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000256|ARBA:ARBA00059988}. |
| O00267 | SUPT5H | S158 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00425 | IGF2BP3 | S248 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O00567 | NOP56 | S528 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14647 | CHD2 | S207 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14654 | IRS4 | S918 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14715 | RGPD8 | Y1027 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14776 | TCERG1 | S834 | ochoa | Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}. |
| O15018 | PDZD2 | S514 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15078 | CEP290 | S2369 | ochoa | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}. |
| O15085 | ARHGEF11 | S556 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15417 | TNRC18 | T1913 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43566 | RGS14 | S20 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60293 | ZFC3H1 | S719 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60293 | ZFC3H1 | S1303 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60675 | MAFK | S25 | ochoa | Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9150357). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). {ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9150357}. |
| O75351 | VPS4B | S102 | ochoa | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:16193069, ECO:0000269|PubMed:18606141}. |
| O75369 | FLNB | S2336 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75530 | EED | S34 | ochoa | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}. |
| O75554 | WBP4 | S262 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O75781 | PALM | S62 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O76021 | RSL1D1 | S90 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O95243 | MBD4 | S262 | psp | Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) | Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}. |
| O95684 | CEP43 | S207 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O96028 | NSD2 | S1238 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P05181 | CYP2E1 | S424 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P07900 | HSP90AA1 | S72 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08195 | SLC3A2 | S410 | psp | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08238 | HSP90AB1 | S67 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P0DJD0 | RGPD1 | S1306 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1314 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | S263 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11277 | SPTB | S2060 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P11388 | TOP2A | S1303 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P11388 | TOP2A | S1377 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P11388 | TOP2A | S1504 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12883 | MYH7 | S851 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P15924 | DSP | S2792 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P21127 | CDK11B | S47 | ochoa|psp | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P21796 | VDAC1 | S46 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P29374 | ARID4A | S542 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P31948 | STIP1 | S460 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P33981 | TTK | S42 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35221 | CTNNA1 | S641 | ochoa|psp | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35251 | RFC1 | S29 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P36383 | GJC1 | S326 | ochoa | Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P42356 | PI4KA | S1826 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P46013 | MKI67 | S563 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S704 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S819 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P48551 | IFNAR2 | S324 | ochoa|psp | Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) | Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:12105218, PubMed:28165510, PubMed:9121453). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:17517919, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059, ECO:0000269|PubMed:8798579, ECO:0000269|PubMed:8969169, ECO:0000269|PubMed:9121453}.; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:7759950}. |
| P49792 | RANBP2 | Y2003 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2297 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51587 | BRCA2 | T363 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52179 | MYOM1 | S1399 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52597 | HNRNPF | S187 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P52701 | MSH6 | S261 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| Q01484 | ANK2 | S846 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01831 | XPC | S398 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02880 | TOP2B | S1344 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02952 | AKAP12 | S629 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S376 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03468 | ERCC6 | S1068 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q04727 | TLE4 | S245 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q09666 | AHNAK | S148 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12955 | ANK3 | S847 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13114 | TRAF3 | S349 | psp | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) | Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Also acts as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:32562145, ECO:0000269|PubMed:33148796, ECO:0000269|PubMed:33608556, ECO:0000269|PubMed:34011520}. |
| Q13428 | TCOF1 | S484 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S769 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13435 | SF3B2 | S436 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13601 | KRR1 | S345 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13769 | THOC5 | S28 | ochoa | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14008 | CKAP5 | S1149 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14008 | CKAP5 | S1861 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14515 | SPARCL1 | S91 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q14573 | ITPR3 | S946 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q15032 | R3HDM1 | S141 | ochoa | R3H domain-containing protein 1 | None |
| Q15051 | IQCB1 | S572 | ochoa | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}. |
| Q15056 | EIF4H | S94 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15057 | ACAP2 | S387 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15059 | BRD3 | S259 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15147 | PLCB4 | S889 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15149 | PLEC | S201 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15652 | JMJD1C | S379 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16666 | IFI16 | S575 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q29RF7 | PDS5A | S1233 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2NKX8 | ERCC6L | S1036 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q49A88 | CCDC14 | S96 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q49AR2 | C5orf22 | S197 | ochoa | UPF0489 protein C5orf22 | None |
| Q53QZ3 | ARHGAP15 | S246 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q562F6 | SGO2 | S1187 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q58FF7 | HSP90AB3P | S67 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S67 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5SSJ5 | HP1BP3 | S47 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T200 | ZC3H13 | S1017 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TEJ8 | THEMIS2 | S606 | ochoa | Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2) | May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0, ECO:0000269|PubMed:20644716}. |
| Q5UIP0 | RIF1 | S1976 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q68D51 | DENND2C | S449 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q68DK7 | MSL1 | S371 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6AI08 | HEATR6 | S336 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6P4R8 | NFRKB | S338 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PKG0 | LARP1 | S225 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UB98 | ANKRD12 | S429 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB99 | ANKRD11 | S73 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6WKZ4 | RAB11FIP1 | S232 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S365 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZS17 | RIPOR1 | S357 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q70Z35 | PREX2 | S1073 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2) | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}. |
| Q70Z53 | FRA10AC1 | S251 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q71F23 | CENPU | S116 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71F23 | CENPU | S141 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q76FK4 | NOL8 | S843 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L0Y3 | TRMT10C | S85 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7RTV3 | ZNF367 | S310 | ochoa | Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) | Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}. |
| Q7Z2Z1 | TICRR | S1590 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3J3 | RGPD4 | Y1028 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1322 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5K2 | WAPL | S77 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z5N4 | SDK1 | S2131 | ochoa | Protein sidekick-1 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}. |
| Q7Z6E9 | RBBP6 | S246 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86UP2 | KTN1 | S75 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UP2 | KTN1 | S79 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q8IXM2 | BACC1 | S146 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IZ40 | RCOR2 | S213 | ochoa | REST corepressor 2 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q8IZT6 | ASPM | S570 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N1G1 | REXO1 | S287 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N1G2 | CMTR1 | S31 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N5P1 | ZC3H8 | S165 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8N6N3 | C1orf52 | S158 | ochoa | UPF0690 protein C1orf52 (BCL10-associated gene protein) | None |
| Q8NEC7 | GSTCD | S232 | ochoa | Glutathione S-transferase C-terminal domain-containing protein | None |
| Q8NEC7 | GSTCD | S234 | ochoa | Glutathione S-transferase C-terminal domain-containing protein | None |
| Q8NF91 | SYNE1 | S8223 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TAF3 | WDR48 | S617 | ochoa | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. |
| Q8TCU6 | PREX1 | S1277 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDD1 | DDX54 | S788 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TEY7 | USP33 | S387 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
| Q8TF01 | PNISR | S467 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q92541 | RTF1 | S652 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92576 | PHF3 | S682 | ochoa | PHD finger protein 3 | None |
| Q92599 | SEPTIN8 | S192 | psp | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92733 | PRCC | S157 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92785 | DPF2 | S200 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92997 | DVL3 | S61 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96AT1 | KIAA1143 | S50 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96D71 | REPS1 | S516 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96G01 | BICD1 | S399 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96HH4 | TMEM169 | S57 | ochoa | Transmembrane protein 169 | None |
| Q96JM3 | CHAMP1 | S632 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KC8 | DNAJC1 | S480 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96L73 | NSD1 | S1139 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96P70 | IPO9 | S890 | ochoa | Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:Q91YE6, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:30855230, ECO:0000269|PubMed:34711951}. |
| Q96QE3 | ATAD5 | S356 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96QE3 | ATAD5 | S1116 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96S38 | RPS6KC1 | S454 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99547 | MPHOSPH6 | S110 | ochoa | M-phase phosphoprotein 6 | RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:26166824}. |
| Q99567 | NUP88 | S655 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99666 | RGPD5 | Y1027 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BPX3 | NCAPG | S674 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BTC0 | DIDO1 | S898 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BV36 | MLPH | S201 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BYF1 | ACE2 | S787 | psp | Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}. |
| Q9BYW2 | SETD2 | S1207 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BYW2 | SETD2 | S1413 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H4A3 | WNK1 | S2012 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H5J8 | TAF1D | S211 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H788 | SH2D4A | S317 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9H8G2 | CAAP1 | S203 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9H9J4 | USP42 | S1172 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HC35 | EML4 | S184 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCH5 | SYTL2 | S517 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCK1 | ZDBF2 | S534 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9HCK1 | ZDBF2 | S1494 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NQV6 | PRDM10 | S424 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NS56 | TOPORS | S499 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NVR2 | INTS10 | S382 | ochoa | Integrator complex subunit 10 (Int10) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:32647223). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386}. |
| Q9NVU0 | POLR3E | S162 | ochoa | DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P36121, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:35637192}. |
| Q9NWQ4 | GPATCH2L | S88 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NZI8 | IGF2BP1 | S248 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9NZU7 | CABP1 | S323 | psp | Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). {ECO:0000250|UniProtKB:O88751, ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}. |
| Q9P0M6 | MACROH2A2 | S173 | ochoa | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}. |
| Q9P289 | STK26 | S309 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9P2D0 | IBTK | S999 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2N5 | RBM27 | S914 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UIK4 | DAPK2 | S349 | ochoa | Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. |
| Q9UJY4 | GGA2 | S233 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UKL3 | CASP8AP2 | S1161 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S1239 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULU4 | ZMYND8 | S707 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULW0 | TPX2 | S101 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULW0 | TPX2 | S157 | psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UN37 | VPS4A | S97 | ochoa | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}. |
| Q9UNL4 | ING4 | S150 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9UQ88 | CDK11A | S47 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2D8 | SSX2IP | S312 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2W7 | KCNIP3 | S63 | psp | Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:16123112, ECO:0000269|PubMed:18957440}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}. |
| Q9Y388 | RBMX2 | S188 | ochoa | RNA-binding motif protein, X-linked 2 | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9Y6R1 | SLC4A4 | S68 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6X9 | MORC2 | S785 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| U3KPZ7 | LOC127814297 | S859 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| O43707 | ACTN4 | S511 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P61769 | B2M | S53 | Sugiyama | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| O60566 | BUB1B | S411 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9H6T3 | RPAP3 | Y88 | Sugiyama | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| P13073 | COX4I1 | S74 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P08575 | PTPRC | S1009 | SIGNOR | Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:2845400, ECO:0000269|PubMed:35767951}.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}. |
| P83881 | RPL36A | S79 | Sugiyama | Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q969Q0 | RPL36AL | S79 | Sugiyama | Ribosomal protein eL42-like (60S ribosomal protein L36a-like) (Large ribosomal subunit protein eL42-like) | None |
| P31946 | YWHAB | S158 | Sugiyama | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P78347 | GTF2I | S392 | EPSD | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q9P2E9 | RRBP1 | S872 | Sugiyama | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| P12270 | TPR | S909 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 1.835311e-08 | 7.736 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.820565e-07 | 6.317 |
| R-HSA-68877 | Mitotic Prometaphase | 1.488582e-06 | 5.827 |
| R-HSA-68886 | M Phase | 4.008137e-05 | 4.397 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.066483e-04 | 3.972 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.244094e-04 | 3.489 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.244094e-04 | 3.489 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.716152e-04 | 3.566 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.692370e-04 | 3.433 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.884824e-04 | 3.051 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.580118e-04 | 3.067 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.149247e-04 | 3.039 |
| R-HSA-380287 | Centrosome maturation | 1.006039e-03 | 2.997 |
| R-HSA-8953854 | Metabolism of RNA | 1.375561e-03 | 2.862 |
| R-HSA-68882 | Mitotic Anaphase | 1.526737e-03 | 2.816 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.574461e-03 | 2.803 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.183965e-03 | 2.661 |
| R-HSA-69275 | G2/M Transition | 2.052886e-03 | 2.688 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.189783e-03 | 2.660 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.512820e-03 | 2.454 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.290000e-03 | 2.368 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.272193e-03 | 2.082 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.900492e-03 | 2.102 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 8.272193e-03 | 2.082 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 8.272193e-03 | 2.082 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.598749e-03 | 2.018 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.361615e-02 | 1.866 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.043922e-02 | 1.981 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.316243e-02 | 1.881 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.415164e-02 | 1.849 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.415164e-02 | 1.849 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.625365e-02 | 1.789 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.625365e-02 | 1.789 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.619909e-02 | 1.791 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.619909e-02 | 1.791 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.152404e-02 | 1.938 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.361615e-02 | 1.866 |
| R-HSA-9930044 | Nuclear RNA decay | 1.625365e-02 | 1.789 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.361615e-02 | 1.866 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.170425e-02 | 1.932 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.389638e-02 | 1.857 |
| R-HSA-373755 | Semaphorin interactions | 1.619909e-02 | 1.791 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.219729e-02 | 1.914 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.518199e-02 | 1.819 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.659318e-02 | 1.575 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.659318e-02 | 1.575 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.659318e-02 | 1.575 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.659318e-02 | 1.575 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.659318e-02 | 1.575 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.659318e-02 | 1.575 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.659318e-02 | 1.575 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.659318e-02 | 1.575 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.736677e-02 | 1.760 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.971786e-02 | 1.705 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.492107e-02 | 1.603 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.632628e-02 | 1.580 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.477158e-02 | 1.606 |
| R-HSA-373756 | SDK interactions | 2.659318e-02 | 1.575 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.781295e-02 | 1.749 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.223589e-02 | 1.653 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.736677e-02 | 1.760 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.224406e-02 | 1.653 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.852147e-02 | 1.732 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.632628e-02 | 1.580 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.632628e-02 | 1.580 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.355759e-02 | 1.628 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.492107e-02 | 1.603 |
| R-HSA-168255 | Influenza Infection | 1.873017e-02 | 1.727 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.675863e-02 | 1.573 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.759834e-02 | 1.559 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.777317e-02 | 1.556 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.444884e-02 | 1.463 |
| R-HSA-162587 | HIV Life Cycle | 3.238893e-02 | 1.490 |
| R-HSA-4839726 | Chromatin organization | 3.063425e-02 | 1.514 |
| R-HSA-5688426 | Deubiquitination | 3.419217e-02 | 1.466 |
| R-HSA-73894 | DNA Repair | 3.459302e-02 | 1.461 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 3.962459e-02 | 1.402 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 3.962459e-02 | 1.402 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.905911e-02 | 1.408 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.962459e-02 | 1.402 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.562898e-02 | 1.448 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.685822e-02 | 1.433 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.562898e-02 | 1.448 |
| R-HSA-3371556 | Cellular response to heat stress | 3.713455e-02 | 1.430 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.732338e-02 | 1.428 |
| R-HSA-75153 | Apoptotic execution phase | 3.732338e-02 | 1.428 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.329686e-02 | 1.364 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.421749e-02 | 1.354 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.248233e-02 | 1.280 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.248233e-02 | 1.280 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.248233e-02 | 1.280 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.248233e-02 | 1.280 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.248233e-02 | 1.280 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.248233e-02 | 1.280 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.248233e-02 | 1.280 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.248233e-02 | 1.280 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.248233e-02 | 1.280 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.248233e-02 | 1.280 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.248233e-02 | 1.280 |
| R-HSA-162906 | HIV Infection | 5.147832e-02 | 1.288 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.706151e-02 | 1.327 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.535425e-02 | 1.343 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 5.199411e-02 | 1.284 |
| R-HSA-72312 | rRNA processing | 5.609513e-02 | 1.251 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 6.516872e-02 | 1.186 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.516872e-02 | 1.186 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 6.516872e-02 | 1.186 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 6.255105e-02 | 1.204 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.116184e-02 | 1.214 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.295963e-02 | 1.201 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 6.516872e-02 | 1.186 |
| R-HSA-191859 | snRNP Assembly | 6.295272e-02 | 1.201 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.295272e-02 | 1.201 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.746443e-02 | 1.171 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.858753e-02 | 1.232 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.801184e-02 | 1.236 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 7.768602e-02 | 1.110 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.022223e-01 | 0.990 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 1.022223e-01 | 0.990 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.261088e-01 | 0.899 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.378137e-01 | 0.861 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.378137e-01 | 0.861 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.378137e-01 | 0.861 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.378137e-01 | 0.861 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.378137e-01 | 0.861 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.493626e-01 | 0.826 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.493626e-01 | 0.826 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.493626e-01 | 0.826 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.830934e-01 | 0.737 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.830934e-01 | 0.737 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.940384e-01 | 0.712 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 2.260054e-01 | 0.646 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.020819e-01 | 0.991 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.363781e-01 | 0.626 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.466124e-01 | 0.608 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.466124e-01 | 0.608 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.567101e-01 | 0.591 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.567101e-01 | 0.591 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.666732e-01 | 0.574 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.666732e-01 | 0.574 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.765033e-01 | 0.558 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.765033e-01 | 0.558 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.862022e-01 | 0.543 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.862022e-01 | 0.543 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.862022e-01 | 0.543 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.862022e-01 | 0.543 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.862022e-01 | 0.543 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.957717e-01 | 0.529 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.957717e-01 | 0.529 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.957717e-01 | 0.529 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.605956e-01 | 0.794 |
| R-HSA-774815 | Nucleosome assembly | 1.605956e-01 | 0.794 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.052135e-01 | 0.515 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.145292e-01 | 0.502 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.046172e-02 | 1.094 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.941533e-01 | 0.712 |
| R-HSA-211999 | CYP2E1 reactions | 3.327894e-01 | 0.478 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.327894e-01 | 0.478 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.990217e-01 | 0.701 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.417371e-01 | 0.466 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.137092e-01 | 0.670 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.235575e-01 | 0.651 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.534989e-01 | 0.814 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.566910e-01 | 0.805 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.696602e-01 | 0.770 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.010809e-02 | 1.154 |
| R-HSA-72172 | mRNA Splicing | 8.438274e-02 | 1.074 |
| R-HSA-192823 | Viral mRNA Translation | 1.998820e-01 | 0.699 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.171935e-01 | 0.663 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.048375e-01 | 0.689 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.436247e-02 | 1.074 |
| R-HSA-73893 | DNA Damage Bypass | 1.796489e-01 | 0.746 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.078453e-01 | 0.512 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.990217e-01 | 0.701 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.830934e-01 | 0.737 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.466124e-01 | 0.608 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.348038e-01 | 0.629 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.492816e-02 | 1.125 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.260054e-01 | 0.646 |
| R-HSA-156902 | Peptide chain elongation | 1.440512e-01 | 0.841 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.348038e-01 | 0.629 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.830934e-01 | 0.737 |
| R-HSA-69091 | Polymerase switching | 1.940384e-01 | 0.712 |
| R-HSA-69109 | Leading Strand Synthesis | 1.940384e-01 | 0.712 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.765033e-01 | 0.558 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.145292e-01 | 0.502 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.287634e-01 | 0.890 |
| R-HSA-4641265 | Repression of WNT target genes | 1.940384e-01 | 0.712 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 7.376067e-02 | 1.132 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.880420e-01 | 0.541 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.567101e-01 | 0.591 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.729503e-01 | 0.762 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 9.003647e-02 | 1.046 |
| R-HSA-9664420 | Killing mechanisms | 2.363781e-01 | 0.626 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.363781e-01 | 0.626 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.466124e-01 | 0.608 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.465716e-01 | 0.834 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.046172e-02 | 1.094 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.681790e-01 | 0.572 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.226293e-01 | 0.491 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.022223e-01 | 0.990 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 2.363781e-01 | 0.626 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.729503e-01 | 0.762 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.127810e-01 | 0.505 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.466124e-01 | 0.608 |
| R-HSA-9694614 | Attachment and Entry | 3.052135e-01 | 0.515 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.003091e-01 | 0.999 |
| R-HSA-192905 | vRNP Assembly | 1.720004e-01 | 0.764 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.940384e-01 | 0.712 |
| R-HSA-162588 | Budding and maturation of HIV virion | 8.960557e-02 | 1.048 |
| R-HSA-9678110 | Attachment and Entry | 2.363781e-01 | 0.626 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.666732e-01 | 0.574 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.052135e-01 | 0.515 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.145292e-01 | 0.502 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.417371e-01 | 0.466 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.003091e-01 | 0.999 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.729503e-01 | 0.762 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.762585e-01 | 0.754 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.781147e-01 | 0.556 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.029028e-01 | 0.519 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.373727e-01 | 0.862 |
| R-HSA-170968 | Frs2-mediated activation | 2.048375e-01 | 0.689 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.378648e-01 | 0.861 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.599037e-01 | 0.796 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 2.466124e-01 | 0.608 |
| R-HSA-3371511 | HSF1 activation | 1.150014e-01 | 0.939 |
| R-HSA-169893 | Prolonged ERK activation events | 2.363781e-01 | 0.626 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 2.048375e-01 | 0.689 |
| R-HSA-5358508 | Mismatch Repair | 2.666732e-01 | 0.574 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.607574e-01 | 0.794 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.154925e-01 | 0.667 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.260054e-01 | 0.646 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.260054e-01 | 0.646 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.145292e-01 | 0.502 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.419190e-01 | 0.616 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.007783e-01 | 0.697 |
| R-HSA-1500620 | Meiosis | 1.317728e-01 | 0.880 |
| R-HSA-5693538 | Homology Directed Repair | 2.634632e-01 | 0.579 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.493626e-01 | 0.826 |
| R-HSA-170984 | ARMS-mediated activation | 1.493626e-01 | 0.826 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.154925e-01 | 0.667 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.260054e-01 | 0.646 |
| R-HSA-1221632 | Meiotic synapsis | 1.990217e-01 | 0.701 |
| R-HSA-9609690 | HCMV Early Events | 3.296113e-01 | 0.482 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.748521e-01 | 0.757 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.327894e-01 | 0.478 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.417371e-01 | 0.466 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.417371e-01 | 0.466 |
| R-HSA-73886 | Chromosome Maintenance | 1.110061e-01 | 0.955 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.142457e-01 | 0.942 |
| R-HSA-392517 | Rap1 signalling | 2.765033e-01 | 0.558 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.862022e-01 | 0.543 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.930540e-01 | 0.714 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.567101e-01 | 0.591 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.957717e-01 | 0.529 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.567101e-01 | 0.591 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.666732e-01 | 0.574 |
| R-HSA-9675135 | Diseases of DNA repair | 1.653240e-01 | 0.782 |
| R-HSA-9609646 | HCMV Infection | 3.003353e-01 | 0.522 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.526570e-01 | 0.597 |
| R-HSA-112307 | Transmission across Electrical Synapses | 7.768602e-02 | 1.110 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 7.768602e-02 | 1.110 |
| R-HSA-112303 | Electric Transmission Across Gap Junctions | 7.768602e-02 | 1.110 |
| R-HSA-425381 | Bicarbonate transporters | 1.720004e-01 | 0.764 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 8.156269e-02 | 1.089 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.260054e-01 | 0.646 |
| R-HSA-9708530 | Regulation of BACH1 activity | 2.363781e-01 | 0.626 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.145292e-01 | 0.502 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.893009e-01 | 0.723 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.483100e-01 | 0.605 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.033177e-01 | 0.692 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.029028e-01 | 0.519 |
| R-HSA-194138 | Signaling by VEGF | 2.925290e-01 | 0.534 |
| R-HSA-9018682 | Biosynthesis of maresins | 3.237207e-01 | 0.490 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 2.466124e-01 | 0.608 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.765033e-01 | 0.558 |
| R-HSA-9610379 | HCMV Late Events | 2.118694e-01 | 0.674 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.022223e-01 | 0.990 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.720004e-01 | 0.764 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 1.720004e-01 | 0.764 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.048375e-01 | 0.689 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.260054e-01 | 0.646 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.260054e-01 | 0.646 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.567101e-01 | 0.591 |
| R-HSA-3371568 | Attenuation phase | 1.328233e-01 | 0.877 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 9.475031e-02 | 1.023 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.237207e-01 | 0.490 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.237207e-01 | 0.490 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.237207e-01 | 0.490 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.696602e-01 | 0.770 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.173571e-01 | 0.498 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.378137e-01 | 0.861 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.417371e-01 | 0.466 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.176591e-01 | 0.929 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.373727e-01 | 0.862 |
| R-HSA-5617833 | Cilium Assembly | 1.536738e-01 | 0.813 |
| R-HSA-913531 | Interferon Signaling | 1.812590e-01 | 0.742 |
| R-HSA-112043 | PLC beta mediated events | 2.383918e-01 | 0.623 |
| R-HSA-199991 | Membrane Trafficking | 1.943317e-01 | 0.711 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.417371e-01 | 0.466 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.980337e-01 | 0.703 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.260054e-01 | 0.646 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.977425e-02 | 1.156 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.137092e-01 | 0.670 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.277077e-01 | 0.485 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.814594e-02 | 1.055 |
| R-HSA-1500931 | Cell-Cell communication | 3.009703e-01 | 0.521 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.855265e-02 | 1.105 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 3.052135e-01 | 0.515 |
| R-HSA-1474165 | Reproduction | 3.144745e-01 | 0.502 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.859510e-02 | 1.105 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.859510e-02 | 1.105 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.261088e-01 | 0.899 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.493626e-01 | 0.826 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.048375e-01 | 0.689 |
| R-HSA-112040 | G-protein mediated events | 2.681790e-01 | 0.572 |
| R-HSA-977225 | Amyloid fiber formation | 3.373340e-01 | 0.472 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.636484e-01 | 0.579 |
| R-HSA-9824446 | Viral Infection Pathways | 2.079156e-01 | 0.682 |
| R-HSA-416700 | Other semaphorin interactions | 2.260054e-01 | 0.646 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.765033e-01 | 0.558 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.378137e-01 | 0.861 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.493626e-01 | 0.826 |
| R-HSA-210991 | Basigin interactions | 2.957717e-01 | 0.529 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.433487e-01 | 0.614 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.765033e-01 | 0.558 |
| R-HSA-72306 | tRNA processing | 2.519169e-01 | 0.599 |
| R-HSA-70171 | Glycolysis | 1.896625e-01 | 0.722 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.052135e-01 | 0.515 |
| R-HSA-9679506 | SARS-CoV Infections | 9.163915e-02 | 1.038 |
| R-HSA-373753 | Nephrin family interactions | 2.862022e-01 | 0.543 |
| R-HSA-597592 | Post-translational protein modification | 3.309356e-01 | 0.480 |
| R-HSA-1538133 | G0 and Early G1 | 9.371162e-02 | 1.028 |
| R-HSA-373760 | L1CAM interactions | 2.562521e-01 | 0.591 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.413363e-02 | 1.026 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.964606e-01 | 0.707 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.417371e-01 | 0.466 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.226293e-01 | 0.491 |
| R-HSA-422475 | Axon guidance | 1.450952e-01 | 0.838 |
| R-HSA-190861 | Gap junction assembly | 1.063419e-01 | 0.973 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.830799e-01 | 0.548 |
| R-HSA-9675108 | Nervous system development | 1.931058e-01 | 0.714 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.979543e-01 | 0.526 |
| R-HSA-68875 | Mitotic Prophase | 2.706996e-01 | 0.568 |
| R-HSA-190828 | Gap junction trafficking | 1.558930e-01 | 0.807 |
| R-HSA-211000 | Gene Silencing by RNA | 7.859510e-02 | 1.105 |
| R-HSA-70326 | Glucose metabolism | 2.598543e-01 | 0.585 |
| R-HSA-5619102 | SLC transporter disorders | 1.067289e-01 | 0.972 |
| R-HSA-109581 | Apoptosis | 9.797942e-02 | 1.009 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.796489e-01 | 0.746 |
| R-HSA-5357801 | Programmed Cell Death | 8.575490e-02 | 1.067 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.925339e-01 | 0.534 |
| R-HSA-2028269 | Signaling by Hippo | 2.567101e-01 | 0.591 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.035345e-01 | 0.691 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.582416e-01 | 0.588 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.127810e-01 | 0.505 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.283097e-01 | 0.892 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.941533e-01 | 0.712 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.437823e-01 | 0.464 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 3.470846e-01 | 0.460 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.474420e-01 | 0.459 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.505653e-01 | 0.455 |
| R-HSA-525793 | Myogenesis | 3.505653e-01 | 0.455 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.505653e-01 | 0.455 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.505653e-01 | 0.455 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.505653e-01 | 0.455 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.505653e-01 | 0.455 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.508732e-01 | 0.455 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.584087e-01 | 0.446 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.592757e-01 | 0.445 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.592757e-01 | 0.445 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.592757e-01 | 0.445 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.592757e-01 | 0.445 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.664394e-01 | 0.436 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.678698e-01 | 0.434 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.678698e-01 | 0.434 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.678698e-01 | 0.434 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.678698e-01 | 0.434 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.678698e-01 | 0.434 |
| R-HSA-622312 | Inflammasomes | 3.678698e-01 | 0.434 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.712444e-01 | 0.430 |
| R-HSA-446728 | Cell junction organization | 3.742679e-01 | 0.427 |
| R-HSA-9663891 | Selective autophagy | 3.760350e-01 | 0.425 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.763491e-01 | 0.424 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.763491e-01 | 0.424 |
| R-HSA-72086 | mRNA Capping | 3.763491e-01 | 0.424 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.763491e-01 | 0.424 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.763491e-01 | 0.424 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.763491e-01 | 0.424 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.838869e-01 | 0.416 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.842917e-01 | 0.415 |
| R-HSA-2424491 | DAP12 signaling | 3.847152e-01 | 0.415 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.847152e-01 | 0.415 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.847152e-01 | 0.415 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.847152e-01 | 0.415 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.847152e-01 | 0.415 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.847152e-01 | 0.415 |
| R-HSA-73884 | Base Excision Repair | 3.855708e-01 | 0.414 |
| R-HSA-69242 | S Phase | 3.875098e-01 | 0.412 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.929696e-01 | 0.406 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.929696e-01 | 0.406 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.947405e-01 | 0.404 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.950433e-01 | 0.403 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.011138e-01 | 0.397 |
| R-HSA-69190 | DNA strand elongation | 4.011138e-01 | 0.397 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.091492e-01 | 0.388 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.091492e-01 | 0.388 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.091492e-01 | 0.388 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.091492e-01 | 0.388 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.091492e-01 | 0.388 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.091492e-01 | 0.388 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.091492e-01 | 0.388 |
| R-HSA-9612973 | Autophagy | 4.162928e-01 | 0.381 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.170772e-01 | 0.380 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.170772e-01 | 0.380 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.170772e-01 | 0.380 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.170772e-01 | 0.380 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.170772e-01 | 0.380 |
| R-HSA-9711097 | Cellular response to starvation | 4.234239e-01 | 0.373 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.248994e-01 | 0.372 |
| R-HSA-5673000 | RAF activation | 4.248994e-01 | 0.372 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.248994e-01 | 0.372 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.248994e-01 | 0.372 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.248994e-01 | 0.372 |
| R-HSA-5205647 | Mitophagy | 4.248994e-01 | 0.372 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.248994e-01 | 0.372 |
| R-HSA-203615 | eNOS activation | 4.248994e-01 | 0.372 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.248994e-01 | 0.372 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.248994e-01 | 0.372 |
| R-HSA-877300 | Interferon gamma signaling | 4.269785e-01 | 0.370 |
| R-HSA-157579 | Telomere Maintenance | 4.276515e-01 | 0.369 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.276515e-01 | 0.369 |
| R-HSA-2262752 | Cellular responses to stress | 4.296669e-01 | 0.367 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.326171e-01 | 0.364 |
| R-HSA-187687 | Signalling to ERKs | 4.326171e-01 | 0.364 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.326171e-01 | 0.364 |
| R-HSA-392499 | Metabolism of proteins | 4.346431e-01 | 0.362 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.350268e-01 | 0.361 |
| R-HSA-3214847 | HATs acetylate histones | 4.368004e-01 | 0.360 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.368004e-01 | 0.360 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.402317e-01 | 0.356 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.402317e-01 | 0.356 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.402317e-01 | 0.356 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.446334e-01 | 0.352 |
| R-HSA-4641258 | Degradation of DVL | 4.477445e-01 | 0.349 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.477445e-01 | 0.349 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.477445e-01 | 0.349 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.477445e-01 | 0.349 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.477445e-01 | 0.349 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.477445e-01 | 0.349 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.503743e-01 | 0.346 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.503743e-01 | 0.346 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.551570e-01 | 0.342 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 4.551570e-01 | 0.342 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.551570e-01 | 0.342 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.551570e-01 | 0.342 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.551570e-01 | 0.342 |
| R-HSA-111885 | Opioid Signalling | 4.593207e-01 | 0.338 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.624705e-01 | 0.335 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.624705e-01 | 0.335 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.696862e-01 | 0.328 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.696862e-01 | 0.328 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.696862e-01 | 0.328 |
| R-HSA-167169 | HIV Transcription Elongation | 4.696862e-01 | 0.328 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.696862e-01 | 0.328 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.696862e-01 | 0.328 |
| R-HSA-202433 | Generation of second messenger molecules | 4.696862e-01 | 0.328 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.696862e-01 | 0.328 |
| R-HSA-9646399 | Aggrephagy | 4.696862e-01 | 0.328 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.696862e-01 | 0.328 |
| R-HSA-5260271 | Diseases of Immune System | 4.696862e-01 | 0.328 |
| R-HSA-71240 | Tryptophan catabolism | 4.696862e-01 | 0.328 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.725811e-01 | 0.326 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.768055e-01 | 0.322 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.792752e-01 | 0.319 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.792752e-01 | 0.319 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.838296e-01 | 0.315 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.838296e-01 | 0.315 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.838296e-01 | 0.315 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.838296e-01 | 0.315 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.838296e-01 | 0.315 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.845066e-01 | 0.315 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.860846e-01 | 0.313 |
| R-HSA-202403 | TCR signaling | 4.899552e-01 | 0.310 |
| R-HSA-165159 | MTOR signalling | 4.907599e-01 | 0.309 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.907599e-01 | 0.309 |
| R-HSA-73928 | Depyrimidination | 4.907599e-01 | 0.309 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.907599e-01 | 0.309 |
| R-HSA-421270 | Cell-cell junction organization | 4.969332e-01 | 0.304 |
| R-HSA-9710421 | Defective pyroptosis | 4.975976e-01 | 0.303 |
| R-HSA-8854214 | TBC/RABGAPs | 4.975976e-01 | 0.303 |
| R-HSA-2172127 | DAP12 interactions | 5.043439e-01 | 0.297 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.072212e-01 | 0.295 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.109999e-01 | 0.292 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.109999e-01 | 0.292 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.153356e-01 | 0.288 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.175671e-01 | 0.286 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.175671e-01 | 0.286 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.175671e-01 | 0.286 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.175671e-01 | 0.286 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.175671e-01 | 0.286 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.175671e-01 | 0.286 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.175671e-01 | 0.286 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.175671e-01 | 0.286 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.277105e-01 | 0.278 |
| R-HSA-9766229 | Degradation of CDH1 | 5.367463e-01 | 0.270 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.367463e-01 | 0.270 |
| R-HSA-9864848 | Complex IV assembly | 5.491089e-01 | 0.260 |
| R-HSA-912446 | Meiotic recombination | 5.491089e-01 | 0.260 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.548056e-01 | 0.256 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.551664e-01 | 0.256 |
| R-HSA-72187 | mRNA 3'-end processing | 5.551664e-01 | 0.256 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.551664e-01 | 0.256 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.551664e-01 | 0.256 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.551664e-01 | 0.256 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.551664e-01 | 0.256 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.611430e-01 | 0.251 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.611430e-01 | 0.251 |
| R-HSA-72649 | Translation initiation complex formation | 5.670396e-01 | 0.246 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.670396e-01 | 0.246 |
| R-HSA-69481 | G2/M Checkpoints | 5.712335e-01 | 0.243 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.728574e-01 | 0.242 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.728574e-01 | 0.242 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.728574e-01 | 0.242 |
| R-HSA-9753281 | Paracetamol ADME | 5.728574e-01 | 0.242 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.734205e-01 | 0.242 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.785973e-01 | 0.238 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.785973e-01 | 0.238 |
| R-HSA-5578775 | Ion homeostasis | 5.785973e-01 | 0.238 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.785973e-01 | 0.238 |
| R-HSA-9658195 | Leishmania infection | 5.793524e-01 | 0.237 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.793524e-01 | 0.237 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.842605e-01 | 0.233 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.898479e-01 | 0.229 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.898479e-01 | 0.229 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.898479e-01 | 0.229 |
| R-HSA-5576891 | Cardiac conduction | 5.900384e-01 | 0.229 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.953605e-01 | 0.225 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.953605e-01 | 0.225 |
| R-HSA-180786 | Extension of Telomeres | 5.953605e-01 | 0.225 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.953605e-01 | 0.225 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.007994e-01 | 0.221 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.007994e-01 | 0.221 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.007994e-01 | 0.221 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.007994e-01 | 0.221 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.061655e-01 | 0.217 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.061655e-01 | 0.217 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.114598e-01 | 0.214 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.114598e-01 | 0.214 |
| R-HSA-9707616 | Heme signaling | 6.114598e-01 | 0.214 |
| R-HSA-1268020 | Mitochondrial protein import | 6.114598e-01 | 0.214 |
| R-HSA-186797 | Signaling by PDGF | 6.114598e-01 | 0.214 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.117900e-01 | 0.213 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.117900e-01 | 0.213 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.192203e-01 | 0.208 |
| R-HSA-211981 | Xenobiotics | 6.218369e-01 | 0.206 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.218369e-01 | 0.206 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.218369e-01 | 0.206 |
| R-HSA-6807070 | PTEN Regulation | 6.223328e-01 | 0.206 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.223328e-01 | 0.206 |
| R-HSA-418990 | Adherens junctions interactions | 6.234741e-01 | 0.205 |
| R-HSA-5663205 | Infectious disease | 6.254861e-01 | 0.204 |
| R-HSA-6798695 | Neutrophil degranulation | 6.255899e-01 | 0.204 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.269214e-01 | 0.203 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.269214e-01 | 0.203 |
| R-HSA-1632852 | Macroautophagy | 6.292383e-01 | 0.201 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.319380e-01 | 0.199 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.368874e-01 | 0.196 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.368874e-01 | 0.196 |
| R-HSA-167172 | Transcription of the HIV genome | 6.417705e-01 | 0.193 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.417705e-01 | 0.193 |
| R-HSA-5218859 | Regulated Necrosis | 6.417705e-01 | 0.193 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.493676e-01 | 0.188 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.513415e-01 | 0.186 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.513415e-01 | 0.186 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.513415e-01 | 0.186 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.560312e-01 | 0.183 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.560312e-01 | 0.183 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.560312e-01 | 0.183 |
| R-HSA-8978934 | Metabolism of cofactors | 6.560312e-01 | 0.183 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.560312e-01 | 0.183 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.606580e-01 | 0.180 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.652229e-01 | 0.177 |
| R-HSA-9749641 | Aspirin ADME | 6.652229e-01 | 0.177 |
| R-HSA-4086398 | Ca2+ pathway | 6.652229e-01 | 0.177 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.686239e-01 | 0.175 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.697266e-01 | 0.174 |
| R-HSA-8852135 | Protein ubiquitination | 6.741701e-01 | 0.171 |
| R-HSA-73887 | Death Receptor Signaling | 6.748510e-01 | 0.171 |
| R-HSA-5689603 | UCH proteinases | 6.785540e-01 | 0.168 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.785540e-01 | 0.168 |
| R-HSA-4086400 | PCP/CE pathway | 6.871465e-01 | 0.163 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.871465e-01 | 0.163 |
| R-HSA-216083 | Integrin cell surface interactions | 6.871465e-01 | 0.163 |
| R-HSA-9659379 | Sensory processing of sound | 6.913566e-01 | 0.160 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.955103e-01 | 0.158 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.955103e-01 | 0.158 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.955103e-01 | 0.158 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.996084e-01 | 0.155 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 6.996084e-01 | 0.155 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.076406e-01 | 0.150 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.154589e-01 | 0.145 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.154589e-01 | 0.145 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.192897e-01 | 0.143 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.230691e-01 | 0.141 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.267979e-01 | 0.139 |
| R-HSA-70268 | Pyruvate metabolism | 7.267979e-01 | 0.139 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.304767e-01 | 0.136 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.341062e-01 | 0.134 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.372342e-01 | 0.132 |
| R-HSA-202424 | Downstream TCR signaling | 7.376871e-01 | 0.132 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.481441e-01 | 0.126 |
| R-HSA-391251 | Protein folding | 7.481441e-01 | 0.126 |
| R-HSA-2559583 | Cellular Senescence | 7.499118e-01 | 0.125 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.515367e-01 | 0.124 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.538143e-01 | 0.123 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.548839e-01 | 0.122 |
| R-HSA-1474290 | Collagen formation | 7.548839e-01 | 0.122 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.572645e-01 | 0.121 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.646584e-01 | 0.117 |
| R-HSA-422356 | Regulation of insulin secretion | 7.709582e-01 | 0.113 |
| R-HSA-190236 | Signaling by FGFR | 7.709582e-01 | 0.113 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.740448e-01 | 0.111 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.782154e-01 | 0.109 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.800945e-01 | 0.108 |
| R-HSA-1483255 | PI Metabolism | 7.830585e-01 | 0.106 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.888679e-01 | 0.103 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.917143e-01 | 0.101 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.917143e-01 | 0.101 |
| R-HSA-9833110 | RSV-host interactions | 7.917143e-01 | 0.101 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.945224e-01 | 0.100 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.954983e-01 | 0.099 |
| R-HSA-418346 | Platelet homeostasis | 7.972929e-01 | 0.098 |
| R-HSA-69239 | Synthesis of DNA | 8.000262e-01 | 0.097 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.027228e-01 | 0.095 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.027228e-01 | 0.095 |
| R-HSA-195721 | Signaling by WNT | 8.036663e-01 | 0.095 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.080079e-01 | 0.093 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.080079e-01 | 0.093 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.181589e-01 | 0.087 |
| R-HSA-397014 | Muscle contraction | 8.210592e-01 | 0.086 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.254200e-01 | 0.083 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.254200e-01 | 0.083 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.254200e-01 | 0.083 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.300996e-01 | 0.081 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.390876e-01 | 0.076 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.390876e-01 | 0.076 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.434024e-01 | 0.074 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.434024e-01 | 0.074 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.455165e-01 | 0.073 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.516897e-01 | 0.070 |
| R-HSA-114608 | Platelet degranulation | 8.536923e-01 | 0.069 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.556681e-01 | 0.068 |
| R-HSA-72766 | Translation | 8.581539e-01 | 0.066 |
| R-HSA-8939211 | ESR-mediated signaling | 8.623188e-01 | 0.064 |
| R-HSA-9717189 | Sensory perception of taste | 8.633090e-01 | 0.064 |
| R-HSA-74160 | Gene expression (Transcription) | 8.651099e-01 | 0.063 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.651555e-01 | 0.063 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.651555e-01 | 0.063 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.669771e-01 | 0.062 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.676557e-01 | 0.062 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.736273e-01 | 0.059 |
| R-HSA-163685 | Integration of energy metabolism | 8.740219e-01 | 0.058 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.806952e-01 | 0.055 |
| R-HSA-9664407 | Parasite infection | 8.806952e-01 | 0.055 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.806952e-01 | 0.055 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.870166e-01 | 0.052 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.870166e-01 | 0.052 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.876614e-01 | 0.052 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.944515e-01 | 0.048 |
| R-HSA-166520 | Signaling by NTRKs | 8.944515e-01 | 0.048 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.951032e-01 | 0.048 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.958601e-01 | 0.048 |
| R-HSA-416476 | G alpha (q) signalling events | 8.969851e-01 | 0.047 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.972872e-01 | 0.047 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.986765e-01 | 0.046 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.013732e-01 | 0.045 |
| R-HSA-69306 | DNA Replication | 9.013992e-01 | 0.045 |
| R-HSA-9609507 | Protein localization | 9.013992e-01 | 0.045 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.027331e-01 | 0.044 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.076307e-01 | 0.042 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.078915e-01 | 0.042 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.103677e-01 | 0.041 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.108889e-01 | 0.041 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.115949e-01 | 0.040 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.153998e-01 | 0.038 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.167078e-01 | 0.038 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.185238e-01 | 0.037 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.216925e-01 | 0.035 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.238932e-01 | 0.034 |
| R-HSA-1643685 | Disease | 9.246534e-01 | 0.034 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.249240e-01 | 0.034 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.259409e-01 | 0.033 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.259409e-01 | 0.033 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.267342e-01 | 0.033 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.275442e-01 | 0.033 |
| R-HSA-418594 | G alpha (i) signalling events | 9.294313e-01 | 0.032 |
| R-HSA-611105 | Respiratory electron transport | 9.308236e-01 | 0.031 |
| R-HSA-1266738 | Developmental Biology | 9.318623e-01 | 0.031 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.391552e-01 | 0.027 |
| R-HSA-983712 | Ion channel transport | 9.404665e-01 | 0.027 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.420701e-01 | 0.026 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.487706e-01 | 0.023 |
| R-HSA-428157 | Sphingolipid metabolism | 9.494657e-01 | 0.023 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.508279e-01 | 0.022 |
| R-HSA-1474244 | Extracellular matrix organization | 9.511187e-01 | 0.022 |
| R-HSA-6805567 | Keratinization | 9.534437e-01 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.563581e-01 | 0.019 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.563827e-01 | 0.019 |
| R-HSA-9748784 | Drug ADME | 9.604886e-01 | 0.018 |
| R-HSA-8951664 | Neddylation | 9.620772e-01 | 0.017 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.660095e-01 | 0.015 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.661259e-01 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.664716e-01 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.665151e-01 | 0.015 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.695358e-01 | 0.013 |
| R-HSA-162582 | Signal Transduction | 9.702175e-01 | 0.013 |
| R-HSA-157118 | Signaling by NOTCH | 9.707621e-01 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.742583e-01 | 0.011 |
| R-HSA-449147 | Signaling by Interleukins | 9.759575e-01 | 0.011 |
| R-HSA-168249 | Innate Immune System | 9.770199e-01 | 0.010 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.774686e-01 | 0.010 |
| R-HSA-1280218 | Adaptive Immune System | 9.778219e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.836776e-01 | 0.007 |
| R-HSA-109582 | Hemostasis | 9.851508e-01 | 0.006 |
| R-HSA-1483257 | Phospholipid metabolism | 9.862529e-01 | 0.006 |
| R-HSA-168256 | Immune System | 9.882090e-01 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 9.926790e-01 | 0.003 |
| R-HSA-211859 | Biological oxidations | 9.950444e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.971076e-01 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.971851e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.979264e-01 | 0.001 |
| R-HSA-112316 | Neuronal System | 9.987589e-01 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 9.997945e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999989e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999996e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK2A2 |
0.839 | 0.691 | 1 | 0.829 |
CK2A1 |
0.830 | 0.646 | 1 | 0.818 |
COT |
0.820 | 0.149 | 2 | 0.826 |
FAM20C |
0.814 | 0.215 | 2 | 0.683 |
MOS |
0.812 | 0.321 | 1 | 0.809 |
GRK7 |
0.806 | 0.346 | 1 | 0.613 |
BMPR1B |
0.806 | 0.228 | 1 | 0.691 |
GRK6 |
0.805 | 0.316 | 1 | 0.694 |
GRK1 |
0.804 | 0.204 | -2 | 0.837 |
DSTYK |
0.802 | 0.102 | 2 | 0.860 |
CLK3 |
0.801 | 0.067 | 1 | 0.661 |
CDC7 |
0.801 | 0.115 | 1 | 0.785 |
CAMK2G |
0.799 | 0.162 | 2 | 0.811 |
IKKB |
0.799 | 0.075 | -2 | 0.764 |
IKKA |
0.797 | 0.141 | -2 | 0.755 |
TGFBR1 |
0.795 | 0.216 | -2 | 0.881 |
BMPR1A |
0.794 | 0.212 | 1 | 0.682 |
ALK2 |
0.792 | 0.237 | -2 | 0.894 |
ACVR2B |
0.791 | 0.198 | -2 | 0.895 |
GRK4 |
0.791 | 0.111 | -2 | 0.875 |
PIM3 |
0.791 | 0.036 | -3 | 0.790 |
RAF1 |
0.790 | -0.056 | 1 | 0.688 |
GRK5 |
0.790 | 0.115 | -3 | 0.819 |
PRPK |
0.789 | -0.037 | -1 | 0.780 |
ACVR2A |
0.787 | 0.179 | -2 | 0.888 |
KIS |
0.787 | 0.004 | 1 | 0.508 |
BMPR2 |
0.787 | -0.007 | -2 | 0.911 |
CAMK2B |
0.786 | 0.158 | 2 | 0.794 |
IKKE |
0.786 | -0.055 | 1 | 0.591 |
PLK3 |
0.786 | 0.179 | 2 | 0.743 |
TBK1 |
0.785 | -0.078 | 1 | 0.595 |
GCN2 |
0.785 | -0.123 | 2 | 0.744 |
NDR2 |
0.785 | 0.004 | -3 | 0.793 |
PLK1 |
0.784 | 0.132 | -2 | 0.882 |
ATM |
0.784 | 0.048 | 1 | 0.590 |
ALK4 |
0.783 | 0.138 | -2 | 0.898 |
NEK6 |
0.783 | -0.032 | -2 | 0.897 |
PDHK4 |
0.782 | -0.130 | 1 | 0.698 |
CAMK1B |
0.782 | -0.018 | -3 | 0.806 |
ATR |
0.781 | -0.028 | 1 | 0.653 |
MLK1 |
0.781 | -0.067 | 2 | 0.772 |
SKMLCK |
0.780 | -0.026 | -2 | 0.849 |
MTOR |
0.780 | -0.111 | 1 | 0.603 |
RSK2 |
0.779 | 0.023 | -3 | 0.714 |
TGFBR2 |
0.779 | -0.034 | -2 | 0.900 |
NEK7 |
0.778 | -0.102 | -3 | 0.771 |
PIM1 |
0.778 | 0.032 | -3 | 0.735 |
CAMK2A |
0.777 | 0.115 | 2 | 0.817 |
PKN3 |
0.776 | -0.035 | -3 | 0.761 |
LATS1 |
0.776 | 0.091 | -3 | 0.803 |
RIPK3 |
0.775 | -0.172 | 3 | 0.403 |
ERK5 |
0.775 | -0.066 | 1 | 0.617 |
HUNK |
0.774 | -0.082 | 2 | 0.747 |
ULK2 |
0.774 | -0.172 | 2 | 0.714 |
CDKL1 |
0.773 | -0.046 | -3 | 0.743 |
PDHK1 |
0.773 | -0.136 | 1 | 0.677 |
CAMLCK |
0.773 | -0.054 | -2 | 0.849 |
NIK |
0.773 | -0.114 | -3 | 0.826 |
NLK |
0.772 | -0.125 | 1 | 0.634 |
PLK2 |
0.772 | 0.144 | -3 | 0.810 |
MLK3 |
0.771 | -0.040 | 2 | 0.716 |
MAPKAPK2 |
0.771 | 0.063 | -3 | 0.663 |
DLK |
0.771 | -0.077 | 1 | 0.665 |
GRK2 |
0.771 | 0.037 | -2 | 0.756 |
MST4 |
0.770 | -0.083 | 2 | 0.805 |
SRPK1 |
0.769 | -0.042 | -3 | 0.704 |
NDR1 |
0.769 | -0.080 | -3 | 0.777 |
LATS2 |
0.769 | -0.007 | -5 | 0.683 |
MARK4 |
0.769 | -0.075 | 4 | 0.813 |
DAPK2 |
0.769 | -0.057 | -3 | 0.802 |
PKCD |
0.768 | -0.054 | 2 | 0.754 |
TTBK2 |
0.768 | -0.059 | 2 | 0.630 |
ANKRD3 |
0.768 | -0.130 | 1 | 0.680 |
GRK3 |
0.768 | 0.076 | -2 | 0.724 |
MLK4 |
0.767 | -0.044 | 2 | 0.679 |
NUAK2 |
0.767 | -0.080 | -3 | 0.782 |
TLK2 |
0.767 | 0.015 | 1 | 0.627 |
WNK1 |
0.767 | -0.137 | -2 | 0.846 |
CAMK2D |
0.766 | -0.028 | -3 | 0.754 |
P90RSK |
0.766 | -0.039 | -3 | 0.718 |
BCKDK |
0.766 | -0.114 | -1 | 0.734 |
PKN2 |
0.765 | -0.095 | -3 | 0.773 |
CHAK2 |
0.765 | -0.145 | -1 | 0.736 |
YSK4 |
0.765 | -0.063 | 1 | 0.627 |
RSK4 |
0.764 | 0.020 | -3 | 0.700 |
ULK1 |
0.764 | -0.162 | -3 | 0.745 |
PRKD1 |
0.764 | -0.068 | -3 | 0.729 |
JNK3 |
0.764 | 0.009 | 1 | 0.474 |
CDK1 |
0.764 | -0.036 | 1 | 0.457 |
P70S6KB |
0.763 | -0.042 | -3 | 0.738 |
PRKX |
0.763 | 0.055 | -3 | 0.646 |
MEK1 |
0.763 | -0.036 | 2 | 0.768 |
TSSK2 |
0.762 | -0.053 | -5 | 0.752 |
MEKK3 |
0.762 | -0.044 | 1 | 0.644 |
AMPKA1 |
0.762 | -0.079 | -3 | 0.786 |
PKR |
0.762 | -0.093 | 1 | 0.696 |
AURA |
0.762 | 0.016 | -2 | 0.636 |
MASTL |
0.762 | -0.231 | -2 | 0.815 |
NEK9 |
0.761 | -0.201 | 2 | 0.770 |
DNAPK |
0.761 | 0.005 | 1 | 0.509 |
CLK2 |
0.761 | 0.020 | -3 | 0.718 |
CDKL5 |
0.761 | -0.066 | -3 | 0.724 |
SRPK2 |
0.761 | -0.036 | -3 | 0.625 |
DRAK1 |
0.761 | -0.024 | 1 | 0.634 |
PAK1 |
0.761 | -0.041 | -2 | 0.774 |
PRKD2 |
0.761 | -0.054 | -3 | 0.699 |
RSK3 |
0.760 | -0.064 | -3 | 0.707 |
PKACG |
0.760 | -0.051 | -2 | 0.746 |
MSK2 |
0.760 | -0.028 | -3 | 0.674 |
SRPK3 |
0.760 | -0.048 | -3 | 0.683 |
MSK1 |
0.760 | 0.006 | -3 | 0.677 |
WNK3 |
0.759 | -0.243 | 1 | 0.656 |
PASK |
0.759 | 0.036 | -3 | 0.798 |
JNK2 |
0.759 | -0.005 | 1 | 0.438 |
ICK |
0.758 | -0.083 | -3 | 0.769 |
AURC |
0.758 | -0.024 | -2 | 0.664 |
BRAF |
0.758 | -0.012 | -4 | 0.830 |
PKACB |
0.758 | 0.010 | -2 | 0.683 |
MAPKAPK3 |
0.758 | -0.048 | -3 | 0.692 |
RIPK1 |
0.758 | -0.248 | 1 | 0.651 |
GSK3A |
0.758 | 0.058 | 4 | 0.480 |
CK1E |
0.757 | 0.004 | -3 | 0.572 |
IRE2 |
0.757 | -0.145 | 2 | 0.705 |
MLK2 |
0.757 | -0.206 | 2 | 0.750 |
TLK1 |
0.757 | -0.010 | -2 | 0.896 |
HIPK4 |
0.757 | -0.106 | 1 | 0.591 |
MYLK4 |
0.757 | -0.043 | -2 | 0.774 |
CDK8 |
0.756 | -0.073 | 1 | 0.475 |
TSSK1 |
0.755 | -0.087 | -3 | 0.804 |
PKCB |
0.755 | -0.072 | 2 | 0.710 |
CAMK4 |
0.754 | -0.108 | -3 | 0.757 |
IRE1 |
0.754 | -0.196 | 1 | 0.647 |
AMPKA2 |
0.754 | -0.091 | -3 | 0.757 |
PKCG |
0.753 | -0.082 | 2 | 0.711 |
DYRK2 |
0.753 | -0.060 | 1 | 0.497 |
CK1D |
0.753 | 0.018 | -3 | 0.522 |
MEKK2 |
0.752 | -0.108 | 2 | 0.737 |
CLK4 |
0.752 | -0.043 | -3 | 0.721 |
NIM1 |
0.751 | -0.172 | 3 | 0.425 |
SMG1 |
0.751 | -0.079 | 1 | 0.607 |
P38G |
0.751 | -0.032 | 1 | 0.375 |
P38B |
0.750 | -0.035 | 1 | 0.448 |
QSK |
0.750 | -0.092 | 4 | 0.781 |
PERK |
0.750 | -0.119 | -2 | 0.907 |
CDK5 |
0.750 | -0.083 | 1 | 0.507 |
CDK3 |
0.750 | -0.046 | 1 | 0.403 |
VRK2 |
0.750 | -0.317 | 1 | 0.690 |
PAK2 |
0.750 | -0.083 | -2 | 0.765 |
PKCA |
0.750 | -0.088 | 2 | 0.701 |
MARK2 |
0.750 | -0.066 | 4 | 0.712 |
MARK3 |
0.749 | -0.065 | 4 | 0.746 |
PAK3 |
0.749 | -0.118 | -2 | 0.771 |
AURB |
0.749 | -0.043 | -2 | 0.661 |
BRSK1 |
0.749 | -0.074 | -3 | 0.729 |
TAO3 |
0.748 | -0.075 | 1 | 0.642 |
MEKK1 |
0.748 | -0.167 | 1 | 0.643 |
PLK4 |
0.748 | -0.108 | 2 | 0.544 |
JNK1 |
0.748 | -0.002 | 1 | 0.438 |
PKCH |
0.747 | -0.107 | 2 | 0.692 |
CDK2 |
0.747 | -0.098 | 1 | 0.525 |
HRI |
0.747 | -0.164 | -2 | 0.906 |
GAK |
0.747 | 0.012 | 1 | 0.691 |
PRP4 |
0.747 | -0.030 | -3 | 0.752 |
CHK1 |
0.747 | -0.054 | -3 | 0.749 |
CK1G1 |
0.747 | -0.041 | -3 | 0.596 |
P38A |
0.747 | -0.072 | 1 | 0.509 |
CK1A2 |
0.746 | -0.006 | -3 | 0.521 |
CDK19 |
0.746 | -0.086 | 1 | 0.439 |
SIK |
0.746 | -0.096 | -3 | 0.701 |
PAK6 |
0.746 | -0.035 | -2 | 0.698 |
ERK1 |
0.746 | -0.061 | 1 | 0.436 |
P38D |
0.746 | -0.015 | 1 | 0.390 |
NEK2 |
0.746 | -0.159 | 2 | 0.744 |
NUAK1 |
0.746 | -0.122 | -3 | 0.736 |
GSK3B |
0.745 | -0.009 | 4 | 0.468 |
ERK2 |
0.745 | -0.079 | 1 | 0.486 |
PKCZ |
0.745 | -0.141 | 2 | 0.723 |
PRKD3 |
0.745 | -0.086 | -3 | 0.678 |
QIK |
0.744 | -0.179 | -3 | 0.757 |
MEK5 |
0.744 | -0.242 | 2 | 0.753 |
ZAK |
0.744 | -0.162 | 1 | 0.606 |
NEK5 |
0.744 | -0.186 | 1 | 0.663 |
PINK1 |
0.743 | -0.155 | 1 | 0.656 |
MST3 |
0.743 | -0.112 | 2 | 0.792 |
PIM2 |
0.743 | -0.046 | -3 | 0.684 |
MNK2 |
0.743 | -0.121 | -2 | 0.775 |
DYRK4 |
0.743 | -0.028 | 1 | 0.439 |
CAMK1G |
0.743 | -0.080 | -3 | 0.700 |
MARK1 |
0.743 | -0.091 | 4 | 0.766 |
MELK |
0.743 | -0.153 | -3 | 0.733 |
MST2 |
0.743 | -0.039 | 1 | 0.655 |
AKT2 |
0.743 | -0.045 | -3 | 0.637 |
CDK13 |
0.742 | -0.103 | 1 | 0.469 |
NEK8 |
0.742 | -0.135 | 2 | 0.763 |
CLK1 |
0.742 | -0.070 | -3 | 0.693 |
SGK3 |
0.742 | -0.054 | -3 | 0.688 |
CDK18 |
0.742 | -0.082 | 1 | 0.431 |
CDK7 |
0.741 | -0.113 | 1 | 0.496 |
HIPK2 |
0.741 | -0.056 | 1 | 0.426 |
MNK1 |
0.741 | -0.111 | -2 | 0.789 |
CHAK1 |
0.740 | -0.240 | 2 | 0.676 |
PKG2 |
0.740 | -0.064 | -2 | 0.679 |
DAPK3 |
0.740 | -0.008 | -3 | 0.752 |
CDK17 |
0.740 | -0.082 | 1 | 0.384 |
SMMLCK |
0.740 | -0.082 | -3 | 0.753 |
DCAMKL1 |
0.740 | -0.083 | -3 | 0.729 |
TTBK1 |
0.739 | -0.106 | 2 | 0.561 |
PHKG1 |
0.739 | -0.171 | -3 | 0.763 |
CAMKK1 |
0.738 | -0.116 | -2 | 0.767 |
PKACA |
0.738 | -0.009 | -2 | 0.630 |
TAK1 |
0.738 | -0.053 | 1 | 0.651 |
GCK |
0.738 | -0.095 | 1 | 0.648 |
PDHK3_TYR |
0.738 | 0.280 | 4 | 0.889 |
EEF2K |
0.738 | -0.073 | 3 | 0.447 |
DAPK1 |
0.737 | -0.001 | -3 | 0.736 |
HIPK1 |
0.737 | -0.079 | 1 | 0.515 |
BRSK2 |
0.736 | -0.155 | -3 | 0.742 |
ALPHAK3 |
0.736 | 0.076 | -1 | 0.740 |
SNRK |
0.735 | -0.225 | 2 | 0.605 |
CDK12 |
0.735 | -0.102 | 1 | 0.442 |
CAMK1D |
0.734 | -0.032 | -3 | 0.633 |
PDHK4_TYR |
0.734 | 0.238 | 2 | 0.833 |
TAO2 |
0.734 | -0.142 | 2 | 0.801 |
WNK4 |
0.734 | -0.216 | -2 | 0.834 |
DYRK1B |
0.733 | -0.060 | 1 | 0.479 |
DYRK1A |
0.733 | -0.083 | 1 | 0.548 |
PDHK1_TYR |
0.733 | 0.227 | -1 | 0.836 |
MAPKAPK5 |
0.733 | -0.143 | -3 | 0.622 |
MAP2K6_TYR |
0.733 | 0.209 | -1 | 0.816 |
TTK |
0.733 | -0.008 | -2 | 0.907 |
DCAMKL2 |
0.732 | -0.105 | -3 | 0.753 |
CDK16 |
0.732 | -0.067 | 1 | 0.401 |
IRAK4 |
0.732 | -0.244 | 1 | 0.645 |
NEK11 |
0.731 | -0.223 | 1 | 0.626 |
AKT1 |
0.730 | -0.056 | -3 | 0.648 |
CAMKK2 |
0.730 | -0.128 | -2 | 0.756 |
SSTK |
0.730 | -0.102 | 4 | 0.759 |
PKCT |
0.730 | -0.132 | 2 | 0.691 |
TNIK |
0.729 | -0.126 | 3 | 0.426 |
MST1 |
0.729 | -0.103 | 1 | 0.644 |
TXK |
0.729 | 0.134 | 1 | 0.759 |
BMPR2_TYR |
0.728 | 0.107 | -1 | 0.832 |
PDK1 |
0.728 | -0.157 | 1 | 0.632 |
LKB1 |
0.728 | -0.157 | -3 | 0.760 |
CDK14 |
0.728 | -0.105 | 1 | 0.466 |
ERK7 |
0.728 | -0.038 | 2 | 0.531 |
MPSK1 |
0.727 | -0.136 | 1 | 0.630 |
MAP2K4_TYR |
0.727 | 0.136 | -1 | 0.814 |
MINK |
0.727 | -0.167 | 1 | 0.637 |
CDK9 |
0.727 | -0.132 | 1 | 0.469 |
DYRK3 |
0.727 | -0.074 | 1 | 0.516 |
P70S6K |
0.727 | -0.092 | -3 | 0.632 |
HPK1 |
0.725 | -0.136 | 1 | 0.634 |
HGK |
0.725 | -0.175 | 3 | 0.424 |
PAK5 |
0.725 | -0.071 | -2 | 0.643 |
IRAK1 |
0.725 | -0.283 | -1 | 0.670 |
PAK4 |
0.724 | -0.063 | -2 | 0.646 |
PKCE |
0.724 | -0.087 | 2 | 0.701 |
HIPK3 |
0.724 | -0.128 | 1 | 0.513 |
VRK1 |
0.723 | -0.222 | 2 | 0.773 |
NEK4 |
0.723 | -0.249 | 1 | 0.638 |
PHKG2 |
0.723 | -0.162 | -3 | 0.740 |
OSR1 |
0.722 | -0.067 | 2 | 0.716 |
SLK |
0.722 | -0.118 | -2 | 0.725 |
KHS2 |
0.722 | -0.105 | 1 | 0.633 |
CDK10 |
0.722 | -0.091 | 1 | 0.455 |
PKCI |
0.721 | -0.145 | 2 | 0.701 |
SGK1 |
0.721 | -0.024 | -3 | 0.555 |
LRRK2 |
0.721 | -0.216 | 2 | 0.787 |
MAP2K7_TYR |
0.720 | -0.006 | 2 | 0.805 |
TESK1_TYR |
0.719 | -0.061 | 3 | 0.487 |
NEK1 |
0.719 | -0.237 | 1 | 0.645 |
KHS1 |
0.719 | -0.143 | 1 | 0.625 |
ROCK2 |
0.719 | -0.062 | -3 | 0.727 |
CK1A |
0.719 | -0.005 | -3 | 0.451 |
EPHA6 |
0.718 | 0.013 | -1 | 0.856 |
BLK |
0.718 | 0.048 | -1 | 0.807 |
RIPK2 |
0.718 | -0.239 | 1 | 0.589 |
MAP3K15 |
0.717 | -0.248 | 1 | 0.591 |
INSRR |
0.717 | -0.014 | 3 | 0.397 |
MRCKB |
0.717 | -0.061 | -3 | 0.682 |
MEK2 |
0.717 | -0.182 | 2 | 0.718 |
EPHB4 |
0.717 | -0.013 | -1 | 0.831 |
FYN |
0.717 | 0.064 | -1 | 0.778 |
MRCKA |
0.717 | -0.065 | -3 | 0.697 |
YES1 |
0.717 | -0.016 | -1 | 0.786 |
LOK |
0.717 | -0.178 | -2 | 0.766 |
AKT3 |
0.715 | -0.053 | -3 | 0.569 |
EPHA4 |
0.715 | 0.040 | 2 | 0.756 |
PINK1_TYR |
0.715 | -0.102 | 1 | 0.690 |
CDK6 |
0.714 | -0.111 | 1 | 0.445 |
SRMS |
0.714 | 0.009 | 1 | 0.713 |
STK33 |
0.714 | -0.186 | 2 | 0.553 |
FER |
0.714 | -0.021 | 1 | 0.724 |
CAMK1A |
0.713 | -0.069 | -3 | 0.602 |
CHK2 |
0.713 | -0.091 | -3 | 0.575 |
YANK3 |
0.713 | -0.061 | 2 | 0.371 |
YSK1 |
0.713 | -0.185 | 2 | 0.751 |
LCK |
0.713 | -0.004 | -1 | 0.800 |
PKN1 |
0.713 | -0.117 | -3 | 0.645 |
MEKK6 |
0.712 | -0.290 | 1 | 0.622 |
EPHB2 |
0.712 | 0.020 | -1 | 0.824 |
MAK |
0.712 | -0.054 | -2 | 0.716 |
DMPK1 |
0.712 | -0.039 | -3 | 0.711 |
FGR |
0.712 | -0.069 | 1 | 0.703 |
SBK |
0.712 | -0.017 | -3 | 0.515 |
CDK4 |
0.711 | -0.109 | 1 | 0.433 |
BUB1 |
0.710 | -0.089 | -5 | 0.723 |
ABL2 |
0.710 | -0.085 | -1 | 0.774 |
PTK2 |
0.710 | 0.102 | -1 | 0.824 |
EPHB1 |
0.710 | -0.032 | 1 | 0.689 |
FLT1 |
0.710 | 0.021 | -1 | 0.846 |
PKMYT1_TYR |
0.710 | -0.215 | 3 | 0.461 |
CK1G3 |
0.709 | 0.010 | -3 | 0.416 |
HCK |
0.709 | -0.060 | -1 | 0.794 |
RET |
0.709 | -0.157 | 1 | 0.626 |
SYK |
0.708 | 0.105 | -1 | 0.801 |
PBK |
0.708 | -0.116 | 1 | 0.636 |
EPHB3 |
0.707 | -0.036 | -1 | 0.820 |
ITK |
0.706 | -0.070 | -1 | 0.760 |
HASPIN |
0.706 | -0.084 | -1 | 0.591 |
JAK3 |
0.706 | -0.090 | 1 | 0.615 |
CSF1R |
0.706 | -0.161 | 3 | 0.397 |
MYO3A |
0.705 | -0.150 | 1 | 0.639 |
KIT |
0.704 | -0.113 | 3 | 0.402 |
FGFR2 |
0.703 | -0.101 | 3 | 0.429 |
TYRO3 |
0.703 | -0.210 | 3 | 0.392 |
EPHA5 |
0.703 | 0.022 | 2 | 0.741 |
ABL1 |
0.703 | -0.123 | -1 | 0.766 |
ROCK1 |
0.703 | -0.077 | -3 | 0.693 |
BMX |
0.703 | -0.054 | -1 | 0.690 |
TEC |
0.702 | -0.063 | -1 | 0.707 |
KDR |
0.702 | -0.119 | 3 | 0.390 |
TYK2 |
0.702 | -0.251 | 1 | 0.622 |
MOK |
0.702 | -0.095 | 1 | 0.530 |
LIMK2_TYR |
0.701 | -0.188 | -3 | 0.815 |
LYN |
0.701 | -0.045 | 3 | 0.370 |
MST1R |
0.701 | -0.237 | 3 | 0.405 |
ROS1 |
0.701 | -0.233 | 3 | 0.376 |
EGFR |
0.701 | 0.020 | 1 | 0.519 |
MYO3B |
0.701 | -0.172 | 2 | 0.763 |
BIKE |
0.701 | -0.071 | 1 | 0.582 |
SRC |
0.700 | -0.026 | -1 | 0.770 |
FGFR3 |
0.700 | -0.065 | 3 | 0.418 |
ASK1 |
0.700 | -0.203 | 1 | 0.583 |
MERTK |
0.700 | -0.095 | 3 | 0.404 |
LIMK1_TYR |
0.700 | -0.225 | 2 | 0.789 |
MET |
0.700 | -0.093 | 3 | 0.390 |
EPHA7 |
0.700 | -0.052 | 2 | 0.743 |
JAK2 |
0.700 | -0.243 | 1 | 0.608 |
DDR1 |
0.699 | -0.165 | 4 | 0.781 |
CK1G2 |
0.699 | -0.002 | -3 | 0.511 |
EPHA3 |
0.698 | -0.047 | 2 | 0.719 |
FGFR4 |
0.697 | -0.020 | -1 | 0.765 |
ERBB2 |
0.697 | -0.090 | 1 | 0.597 |
FLT3 |
0.697 | -0.168 | 3 | 0.386 |
EPHA8 |
0.697 | -0.029 | -1 | 0.806 |
CRIK |
0.697 | -0.068 | -3 | 0.634 |
STLK3 |
0.697 | -0.135 | 1 | 0.596 |
TNK2 |
0.696 | -0.165 | 3 | 0.378 |
FRK |
0.696 | -0.096 | -1 | 0.818 |
TAO1 |
0.695 | -0.184 | 1 | 0.578 |
PKG1 |
0.695 | -0.096 | -2 | 0.596 |
NTRK1 |
0.695 | -0.129 | -1 | 0.784 |
ERBB4 |
0.694 | -0.005 | 1 | 0.551 |
INSR |
0.694 | -0.118 | 3 | 0.374 |
PDGFRB |
0.694 | -0.218 | 3 | 0.401 |
PTK2B |
0.694 | -0.056 | -1 | 0.734 |
FGFR1 |
0.694 | -0.159 | 3 | 0.402 |
NEK3 |
0.693 | -0.296 | 1 | 0.594 |
LTK |
0.692 | -0.152 | 3 | 0.381 |
FLT4 |
0.692 | -0.126 | 3 | 0.402 |
EPHA2 |
0.691 | -0.018 | -1 | 0.797 |
AXL |
0.691 | -0.182 | 3 | 0.398 |
BTK |
0.691 | -0.173 | -1 | 0.716 |
ALK |
0.691 | -0.179 | 3 | 0.364 |
NTRK3 |
0.689 | -0.117 | -1 | 0.740 |
TEK |
0.688 | -0.210 | 3 | 0.369 |
NTRK2 |
0.688 | -0.176 | 3 | 0.394 |
IGF1R |
0.688 | -0.074 | 3 | 0.352 |
NEK10_TYR |
0.688 | -0.156 | 1 | 0.543 |
PTK6 |
0.687 | -0.155 | -1 | 0.690 |
CSK |
0.687 | -0.102 | 2 | 0.741 |
JAK1 |
0.686 | -0.210 | 1 | 0.568 |
MATK |
0.686 | -0.107 | -1 | 0.696 |
DDR2 |
0.686 | -0.115 | 3 | 0.390 |
WEE1_TYR |
0.684 | -0.155 | -1 | 0.672 |
YANK2 |
0.682 | -0.079 | 2 | 0.392 |
TNNI3K_TYR |
0.682 | -0.173 | 1 | 0.639 |
EPHA1 |
0.681 | -0.186 | 3 | 0.369 |
AAK1 |
0.679 | -0.059 | 1 | 0.489 |
TNK1 |
0.679 | -0.261 | 3 | 0.387 |
PDGFRA |
0.679 | -0.304 | 3 | 0.391 |
ZAP70 |
0.678 | -0.011 | -1 | 0.686 |
FES |
0.667 | -0.124 | -1 | 0.668 |
MUSK |
0.664 | -0.180 | 1 | 0.522 |