Motif 551 (n=175)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0B4J203 None S244 ochoa receptor protein-tyrosine kinase (EC 2.7.10.1) None
A8MYA2 CXorf49; S65 ochoa Uncharacterized protein CXorf49 None
H3BQZ7 HNRNPUL2-BSCL2 S185 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 None
H7BY64 ZNF511-PRAP1 S151 ochoa ZNF511-PRAP1 readthrough None
H8Y6P7 GCOM1 S541 ochoa DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) None
O14646 CHD1 S1371 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14776 TCERG1 S638 ochoa Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}.
O14974 PPP1R12A S678 psp Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15266 SHOX S106 psp Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) Controls fundamental aspects of growth and development.
O43318 MAP3K7 S393 ochoa Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}.
O43900 PRICKLE3 S482 ochoa Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}.
O60565 GREM1 S44 ochoa Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}.
O75069 TMCC2 S75 ochoa Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}.
O75376 NCOR1 S388 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75449 KATNA1 S93 ochoa Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.
O94880 PHF14 S208 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O94885 SASH1 S614 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94886 TMEM63A S739 ochoa Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A) Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39716028}.
O95155 UBE4B S124 ochoa Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}.
O95674 CDS2 S21 ochoa Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.
P00488 F13A1 S124 ochoa Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. {ECO:0000269|PubMed:27363989}.
P0CAP2 POLR2M S144 ochoa DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}.
P11717 IGF2R S2409 ochoa|psp Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.
P12429 ANXA3 S146 ochoa Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
P12882 MYH1 S1832 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P13521 SCG2 S395 ochoa Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}.
P16157 ANK1 S1666 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P16383 GCFC2 S180 ochoa Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}.
P17028 ZNF24 S132 ochoa Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}.
P20338 RAB4A S190 ochoa Ras-related protein Rab-4A (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}.
P21860 ERBB3 S1104 ochoa Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}.
P23458 JAK1 S857 ochoa Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}.
P23759 PAX7 S207 ochoa Paired box protein Pax-7 (HuP1) Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. {ECO:0000269|PubMed:31092906}.
P23760 PAX3 S209 ochoa Paired box protein Pax-3 (HuP2) Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}.
P25686 DNAJB2 S264 psp DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}.
P29374 ARID4A S455 ochoa AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
P42331 ARHGAP25 S474 ochoa Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
P46013 MKI67 S3082 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46100 ATRX S1322 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46940 IQGAP1 S1414 ochoa Ras GTPase-activating-like protein IQGAP1 (p195) Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.
P49321 NASP S321 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P49792 RANBP2 S1110 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2493 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50148 GNAQ S198 ochoa Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}.
P51114 FXR1 S494 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P51116 FXR2 S533 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P52701 MSH6 S227 ochoa|psp DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P52701 MSH6 S285 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P55060 CSE1L S366 ochoa Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.
P67809 YBX1 S174 ochoa|psp Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}.
P78352 DLG4 S480 ochoa Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}.
P78524 DENND2B S651 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
Q00987 MDM2 S166 ochoa|psp E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}.
Q03701 CEBPZ S34 ochoa CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) Stimulates transcription from the HSP70 promoter.
Q04837 SSBP1 S70 ochoa Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}.
Q07157 TJP1 S290 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q12873 CHD3 S88 ochoa Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.
Q13315 ATM S1891 ochoa|psp Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13435 SF3B2 S778 ochoa Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
Q13439 GOLGA4 S122 ochoa Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.
Q13459 MYO9B S1999 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q14188 TFDP2 S117 ochoa Transcription factor Dp-2 (E2F dimerization partner 2) Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000305|PubMed:20176812}.
Q14684 RRP1B S460 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q15746 MYLK S1091 ochoa Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q16891 IMMT S518 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q1KMD3 HNRNPUL2 S185 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) None
Q3L8U1 CHD9 S1468 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q52LR7 EPC2 S119 ochoa Enhancer of polycomb homolog 2 (EPC-like) May play a role in transcription or DNA repair. {ECO:0000250}.
Q53GS9 USP39 S82 ochoa Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}.
Q5BKX6 SLC45A4 S289 ochoa Solute carrier family 45 member 4 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}.
Q5C9Z4 NOM1 S57 ochoa Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}.
Q5JVF3 PCID2 S24 ochoa PCI domain-containing protein 2 (CSN12-like protein) Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}.
Q5QJE6 DNTTIP2 S88 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5QJE6 DNTTIP2 S92 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5TCZ1 SH3PXD2A S567 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5THJ4 VPS13D S663 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5UIP0 RIF1 S1526 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5UIP0 RIF1 S1552 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5UIP0 RIF1 S1709 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5W0B1 OBI1 S75 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q6AZW8 ZNF660 S27 ochoa Zinc finger protein 660 May be involved in transcriptional regulation.
Q6F5E8 CARMIL2 S1253 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6NWY9 PRPF40B S847 ochoa Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}.
Q6P2Q9 PRPF8 S2060 ochoa Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}.
Q6P3W7 SCYL2 S660 ochoa SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). {ECO:0000250|UniProtKB:Q8CFE4, ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521, ECO:0000305|PubMed:15809293, ECO:0000305|PubMed:16914521}.
Q6P4E1 GOLM2 S332 ochoa Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) None
Q6PH81 C16orf87 S47 ochoa UPF0547 protein C16orf87 None
Q6UN15 FIP1L1 S244 ochoa Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
Q6ZN30 BNC2 S367 ochoa Zinc finger protein basonuclin-2 Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}.
Q6ZUJ8 PIK3AP1 S573 ochoa Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
Q71F23 CENPU S116 ochoa Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
Q71H61 ILDR2 S426 ochoa Immunoglobulin-like domain-containing receptor 2 (Angulin-3) May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}.
Q76FK4 NOL8 S304 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q76G19 PDZD4 S236 ochoa PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) None
Q76N89 HECW1 S540 ochoa E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Q7L4I2 RSRC2 S105 ochoa Arginine/serine-rich coiled-coil protein 2 None
Q7Z3K6 MIER3 S156 ochoa Mesoderm induction early response protein 3 (Mi-er3) Transcriptional repressor. {ECO:0000250}.
Q7Z401 DENND4A S1128 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z5K2 WAPL S202 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q86US8 SMG6 S874 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q86V48 LUZP1 S961 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q8IVT5 KSR1 S569 ochoa Kinase suppressor of Ras 1 (EC 2.7.11.1) Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.
Q8IW35 CEP97 S728 ochoa Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}.
Q8IWU2 LMTK2 S1111 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8IX21 SLF2 S578 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IZ40 RCOR2 S213 ochoa REST corepressor 2 May act as a component of a corepressor complex that represses transcription. {ECO:0000305}.
Q8N3V7 SYNPO S718 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N8U2 CDYL2 S163 ochoa Chromodomain Y-like protein 2 (CDY-like 2) None
Q8NBJ4 GOLM1 S360 ochoa Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) Unknown. Cellular response protein to viral infection.
Q8NFC6 BOD1L1 S1124 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8NFT8 DNER S688 ochoa Delta and Notch-like epidermal growth factor-related receptor Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.
Q8TDJ6 DMXL2 S463 ochoa DmX-like protein 2 (Rabconnectin-3) May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
Q8TF44 C2CD4C S168 ochoa C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) None
Q8WVM7 STAG1 S24 ochoa Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Q8WVS4 DYNC2I1 S176 ochoa Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}.
Q8WWI1 LMO7 S280 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q92614 MYO18A S1974 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92628 KIAA0232 S1082 ochoa Uncharacterized protein KIAA0232 None
Q92834 RPGR S895 ochoa X-linked retinitis pigmentosa GTPase regulator Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:20631154). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (PubMed:20631154). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (PubMed:21933838). May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). {ECO:0000250|UniProtKB:Q9R0X5, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:21933838}.
Q92997 DVL3 T133 ochoa|psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q96AJ9 VTI1A S111 ochoa Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}.
Q96B97 SH3KBP1 S86 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96CC6 RHBDF1 S309 ochoa Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}.
Q96DR7 ARHGEF26 S296 ochoa Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
Q96EI5 TCEAL4 S108 ochoa Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4) May be involved in transcriptional regulation.
Q96I99 SUCLG2 S280 ochoa Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. {ECO:0000255|HAMAP-Rule:MF_03221}.
Q96JQ2 CLMN S927 ochoa Calmin (Calponin-like transmembrane domain protein) None
Q96K76 USP47 S1017 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96L73 NSD1 S1143 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96M11 HYLS1 S83 ochoa Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
Q96PU5 NEDD4L S231 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96QE3 ATAD5 S306 ochoa ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}.
Q96RS0 TGS1 S89 ochoa Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Q96T23 RSF1 S1221 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q99700 ATXN2 S788 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q99714 HSD17B10 S67 ochoa 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubMed:28888424, PubMed:9553139). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678, PubMed:9553139). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:18996107, PubMed:19706438, PubMed:20077426). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}.
Q99733 NAP1L4 S309 ochoa Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.
Q9BV36 MLPH S318 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9C099 LRRCC1 S333 ochoa Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein) Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. {ECO:0000269|PubMed:18728398}.
Q9H0W5 CCDC8 S401 ochoa Coiled-coil domain-containing protein 8 Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Q9H2F5 EPC1 S119 ochoa Enhancer of polycomb homolog 1 Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.
Q9H8E8 KAT14 S428 ochoa Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269|PubMed:19103755}.
Q9H9A7 RMI1 S265 ochoa RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.
Q9HAU0 PLEKHA5 S351 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9HCG8 CWC22 S831 ochoa Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
Q9HCK8 CHD8 S1424 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NRL2 BAZ1A T731 ochoa Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.
Q9NVA4 TMEM184C S344 ochoa Transmembrane protein 184C (Transmembrane protein 34) Possible tumor suppressor which may play a role in cell growth. {ECO:0000269|PubMed:17072649}.
Q9NX94 WBP1L S228 ochoa WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) None
Q9NY61 AATF S321 ochoa|psp Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}.
Q9NZM1 MYOF S174 ochoa Myoferlin (Fer-1-like protein 3) Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.
Q9UBL3 ASH2L S92 ochoa Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
Q9UIB8 CD84 S317 ochoa SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). {ECO:0000250|UniProtKB:Q18PI6, ECO:0000269|PubMed:11564780, ECO:0000269|PubMed:12115647, ECO:0000269|PubMed:12928397, ECO:0000269|PubMed:12962726, ECO:0000269|PubMed:16037392, ECO:0000269|PubMed:22068234, ECO:0000269|PubMed:29434592, ECO:0000305}.
Q9UIS9 MBD1 S391 ochoa Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}.
Q9UKG1 APPL1 S491 ochoa DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.
Q9UKI8 TLK1 S109 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9UKK3 PARP4 S1529 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9UKV8 AGO2 S672 psp Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}.
Q9UKX2 MYH2 S1834 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULU4 ZMYND8 S533 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UM54 MYO6 S1019 ochoa Unconventional myosin-VI (Unconventional myosin-6) Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}.
Q9UPQ7 PDZRN3 S584 ochoa E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}.
Q9UQ80 PA2G4 S345 ochoa Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.
Q9Y266 NUDC S281 ochoa Nuclear migration protein nudC (Nuclear distribution protein C homolog) Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.
Q9Y4J8 DTNA S641 ochoa Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y5Q9 GTF3C3 S51 ochoa General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Q9Y6X4 FAM169A S637 ochoa Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) None
P07814 EPRS1 S1122 Sugiyama Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}.
P53621 COPA S268 Sugiyama Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.
P52907 CAPZA1 S244 Sugiyama F-actin-capping protein subunit alpha-1 (CapZ alpha-1) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}.
P50416 CPT1A S371 Sugiyama Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}.
P47755 CAPZA2 S244 Sugiyama F-actin-capping protein subunit alpha-2 (CapZ alpha-2) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Q8WTQ7 GRK7 S490 SIGNOR|Sugiyama Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7) Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}.
Q9HAU0 PLEKHA5 S832 Sugiyama Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q96JH7 VCPIP1 S1079 Sugiyama Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}.
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reactome_id name p -log10_p
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.000067 4.176
R-HSA-9834899 Specification of the neural plate border 0.000184 3.735
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.000916 3.038
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.001473 2.832
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.001638 2.786
R-HSA-447038 NrCAM interactions 0.003018 2.520
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.003913 2.407
R-HSA-1592230 Mitochondrial biogenesis 0.004214 2.375
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.003794 2.421
R-HSA-9006936 Signaling by TGFB family members 0.004677 2.330
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.022595 1.646
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.022595 1.646
R-HSA-9673013 Diseases of Telomere Maintenance 0.022595 1.646
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.022595 1.646
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.022595 1.646
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 0.022595 1.646
R-HSA-2470946 Cohesin Loading onto Chromatin 0.006024 2.220
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 0.055539 1.255
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.055539 1.255
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.055539 1.255
R-HSA-8941237 Invadopodia formation 0.055539 1.255
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.055539 1.255
R-HSA-1306955 GRB7 events in ERBB2 signaling 0.066273 1.179
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.009955 2.002
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.076886 1.114
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.087379 1.059
R-HSA-9017802 Noncanonical activation of NOTCH3 0.087379 1.059
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.087379 1.059
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.097753 1.010
R-HSA-9732724 IFNG signaling activates MAPKs 0.108010 0.967
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.118150 0.928
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.031273 1.505
R-HSA-9020958 Interleukin-21 signaling 0.128177 0.892
R-HSA-201688 WNT mediated activation of DVL 0.128177 0.892
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.033684 1.473
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.033684 1.473
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.033684 1.473
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.033684 1.473
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.138089 0.860
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.147890 0.830
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.049561 1.305
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.176632 0.753
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.061357 1.212
R-HSA-72165 mRNA Splicing - Minor Pathway 0.024592 1.609
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.185997 0.730
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.195256 0.709
R-HSA-6785631 ERBB2 Regulates Cell Motility 0.195256 0.709
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.204410 0.689
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.213460 0.671
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.097858 1.009
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.101425 0.994
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.052054 1.284
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.248650 0.604
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.248650 0.604
R-HSA-202040 G-protein activation 0.257199 0.590
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.123534 0.908
R-HSA-774815 Nucleosome assembly 0.123534 0.908
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.265652 0.576
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.265652 0.576
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.265652 0.576
R-HSA-912526 Interleukin receptor SHC signaling 0.282273 0.549
R-HSA-72163 mRNA Splicing - Major Pathway 0.011835 1.927
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.093885 1.027
R-HSA-141424 Amplification of signal from the kinetochores 0.093885 1.027
R-HSA-72172 mRNA Splicing 0.015193 1.818
R-HSA-445095 Interaction between L1 and Ankyrins 0.314399 0.503
R-HSA-1989781 PPARA activates gene expression 0.049619 1.304
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.337551 0.472
R-HSA-8957275 Post-translational protein phosphorylation 0.129948 0.886
R-HSA-5578749 Transcriptional regulation by small RNAs 0.232607 0.633
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.051634 1.287
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.007904 2.102
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.274708 0.561
R-HSA-8943723 Regulation of PTEN mRNA translation 0.282273 0.549
R-HSA-5693607 Processing of DNA double-strand break ends 0.270494 0.568
R-HSA-4641258 Degradation of DVL 0.090836 1.042
R-HSA-9656223 Signaling by RAF1 mutants 0.108665 0.964
R-HSA-9664873 Pexophagy 0.138089 0.860
R-HSA-8854691 Interleukin-20 family signaling 0.282273 0.549
R-HSA-8983432 Interleukin-15 signaling 0.167160 0.777
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.048630 1.313
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.274010 0.562
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.274010 0.562
R-HSA-6804757 Regulation of TP53 Degradation 0.013591 1.867
R-HSA-191650 Regulation of gap junction activity 0.066273 1.179
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.176632 0.753
R-HSA-9649948 Signaling downstream of RAS mutants 0.127325 0.895
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.127325 0.895
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.127325 0.895
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.329922 0.482
R-HSA-6783589 Interleukin-6 family signaling 0.290442 0.537
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.016232 1.790
R-HSA-1059683 Interleukin-6 signaling 0.176632 0.753
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.222408 0.653
R-HSA-5693537 Resolution of D-Loop Structures 0.077277 1.112
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.076886 1.114
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.185997 0.730
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.073997 1.131
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.073997 1.131
R-HSA-9664420 Killing mechanisms 0.204410 0.689
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 0.204410 0.689
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.204410 0.689
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.090836 1.042
R-HSA-8953750 Transcriptional Regulation by E2F6 0.097858 1.009
R-HSA-5674135 MAP2K and MAPK activation 0.108665 0.964
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.337551 0.472
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.016232 1.790
R-HSA-6802957 Oncogenic MAPK signaling 0.091649 1.038
R-HSA-9020558 Interleukin-2 signaling 0.147890 0.830
R-HSA-1500620 Meiosis 0.287343 0.542
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.020131 1.696
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.337551 0.472
R-HSA-5693532 DNA Double-Strand Break Repair 0.310784 0.508
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.306504 0.514
R-HSA-9675126 Diseases of mitotic cell cycle 0.070763 1.150
R-HSA-3214815 HDACs deacetylate histones 0.036286 1.440
R-HSA-69541 Stabilization of p53 0.097858 1.009
R-HSA-6807878 COPI-mediated anterograde transport 0.035234 1.453
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.211699 0.674
R-HSA-8984722 Interleukin-35 Signalling 0.167160 0.777
R-HSA-399997 Acetylcholine regulates insulin secretion 0.213460 0.671
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.290442 0.537
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.314399 0.503
R-HSA-69618 Mitotic Spindle Checkpoint 0.135084 0.869
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.080603 1.094
R-HSA-6802949 Signaling by RAS mutants 0.127325 0.895
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.265652 0.576
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.025772 1.589
R-HSA-8985947 Interleukin-9 signaling 0.118150 0.928
R-HSA-212165 Epigenetic regulation of gene expression 0.200587 0.698
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 0.033702 1.472
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.066273 1.179
R-HSA-8866376 Reelin signalling pathway 0.076886 1.114
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.013057 1.884
R-HSA-8875656 MET receptor recycling 0.118150 0.928
R-HSA-190873 Gap junction degradation 0.128177 0.892
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.138089 0.860
R-HSA-451306 Ionotropic activity of kainate receptors 0.147890 0.830
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.167160 0.777
R-HSA-877312 Regulation of IFNG signaling 0.167160 0.777
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.176632 0.753
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.195256 0.709
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.080603 1.094
R-HSA-350054 Notch-HLH transcription pathway 0.274010 0.562
R-HSA-400451 Free fatty acids regulate insulin secretion 0.282273 0.549
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.290442 0.537
R-HSA-9839394 TGFBR3 expression 0.298519 0.525
R-HSA-8949613 Cristae formation 0.314399 0.503
R-HSA-191859 snRNP Assembly 0.178714 0.748
R-HSA-194441 Metabolism of non-coding RNA 0.178714 0.748
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.220042 0.657
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.333378 0.477
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.329922 0.482
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.290442 0.537
R-HSA-9020956 Interleukin-27 signaling 0.138089 0.860
R-HSA-8856688 Golgi-to-ER retrograde transport 0.240054 0.620
R-HSA-68877 Mitotic Prometaphase 0.097365 1.012
R-HSA-447043 Neurofascin interactions 0.097753 1.010
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.231255 0.636
R-HSA-9620244 Long-term potentiation 0.298519 0.525
R-HSA-8863795 Downregulation of ERBB2 signaling 0.337551 0.472
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.041038 1.387
R-HSA-5358508 Mismatch Repair 0.231255 0.636
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.138858 0.857
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.138858 0.857
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.316712 0.499
R-HSA-111448 Activation of NOXA and translocation to mitochondria 0.066273 1.179
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.108010 0.967
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.128177 0.892
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.185997 0.730
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.094328 1.025
R-HSA-9707616 Heme signaling 0.047025 1.328
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.161752 0.791
R-HSA-1266695 Interleukin-7 signaling 0.298519 0.525
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.128177 0.892
R-HSA-8849932 Synaptic adhesion-like molecules 0.231255 0.636
R-HSA-428930 Thromboxane signalling through TP receptor 0.290442 0.537
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.298519 0.525
R-HSA-2467813 Separation of Sister Chromatids 0.059058 1.229
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.329222 0.483
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.055539 1.255
R-HSA-9675151 Disorders of Developmental Biology 0.024479 1.611
R-HSA-112411 MAPK1 (ERK2) activation 0.128177 0.892
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.157580 0.802
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.157580 0.802
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.157580 0.802
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 0.240002 0.620
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.257199 0.590
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.322205 0.492
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.337551 0.472
R-HSA-9843745 Adipogenesis 0.089281 1.049
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.306504 0.514
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.124885 0.903
R-HSA-5633007 Regulation of TP53 Activity 0.054745 1.262
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.134988 0.870
R-HSA-201681 TCF dependent signaling in response to WNT 0.083447 1.079
R-HSA-1257604 PIP3 activates AKT signaling 0.292666 0.534
R-HSA-9022692 Regulation of MECP2 expression and activity 0.073997 1.131
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.083972 1.076
R-HSA-1963642 PI3K events in ERBB2 signaling 0.222408 0.653
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.162546 0.789
R-HSA-193648 NRAGE signals death through JNK 0.166563 0.778
R-HSA-5684996 MAPK1/MAPK3 signaling 0.294870 0.530
R-HSA-5673001 RAF/MAP kinase cascade 0.279505 0.554
R-HSA-69615 G1/S DNA Damage Checkpoints 0.195116 0.710
R-HSA-199991 Membrane Trafficking 0.044539 1.351
R-HSA-2559585 Oncogene Induced Senescence 0.083972 1.076
R-HSA-447115 Interleukin-12 family signaling 0.098424 1.007
R-HSA-69620 Cell Cycle Checkpoints 0.100962 0.996
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.014746 1.831
R-HSA-399719 Trafficking of AMPA receptors 0.009098 2.041
R-HSA-110056 MAPK3 (ERK1) activation 0.138089 0.860
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.014442 1.840
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.195256 0.709
R-HSA-113510 E2F mediated regulation of DNA replication 0.240002 0.620
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.265652 0.576
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.174648 0.758
R-HSA-69473 G2/M DNA damage checkpoint 0.241009 0.618
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.326329 0.486
R-HSA-1640170 Cell Cycle 0.076234 1.118
R-HSA-5653656 Vesicle-mediated transport 0.155605 0.808
R-HSA-3214841 PKMTs methylate histone lysines 0.105028 0.979
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.337551 0.472
R-HSA-6787450 tRNA modification in the mitochondrion 0.213460 0.671
R-HSA-8953854 Metabolism of RNA 0.182606 0.738
R-HSA-3858494 Beta-catenin independent WNT signaling 0.255241 0.593
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.041332 1.384
R-HSA-114452 Activation of BH3-only proteins 0.337551 0.472
R-HSA-73886 Chromosome Maintenance 0.201420 0.696
R-HSA-157858 Gap junction trafficking and regulation 0.138858 0.857
R-HSA-9675135 Diseases of DNA repair 0.024592 1.609
R-HSA-5683057 MAPK family signaling cascades 0.244264 0.612
R-HSA-195721 Signaling by WNT 0.074086 1.130
R-HSA-447041 CHL1 interactions 0.108010 0.967
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 0.147890 0.830
R-HSA-5682910 LGI-ADAM interactions 0.147890 0.830
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.167160 0.777
R-HSA-9005895 Pervasive developmental disorders 0.167160 0.777
R-HSA-9697154 Disorders of Nervous System Development 0.167160 0.777
R-HSA-1483148 Synthesis of PG 0.213460 0.671
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.257199 0.590
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.265652 0.576
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.314399 0.503
R-HSA-9837999 Mitochondrial protein degradation 0.117429 0.930
R-HSA-3214847 HATs acetylate histones 0.132507 0.878
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.253636 0.596
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.337551 0.472
R-HSA-1169408 ISG15 antiviral mechanism 0.245215 0.610
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.070763 1.150
R-HSA-4086398 Ca2+ pathway 0.236806 0.626
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.213460 0.671
R-HSA-9768759 Regulation of NPAS4 gene expression 0.222408 0.653
R-HSA-9909396 Circadian clock 0.028385 1.547
R-HSA-199977 ER to Golgi Anterograde Transport 0.121829 0.914
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.076649 1.115
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.306504 0.514
R-HSA-1852241 Organelle biogenesis and maintenance 0.042778 1.369
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.028934 1.539
R-HSA-9671555 Signaling by PDGFR in disease 0.038715 1.412
R-HSA-6807004 Negative regulation of MET activity 0.248650 0.604
R-HSA-112409 RAF-independent MAPK1/3 activation 0.274010 0.562
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.265652 0.576
R-HSA-1236394 Signaling by ERBB4 0.068613 1.164
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.096144 1.017
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.174648 0.758
R-HSA-8878171 Transcriptional regulation by RUNX1 0.310160 0.508
R-HSA-3700989 Transcriptional Regulation by TP53 0.106948 0.971
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.009099 2.041
R-HSA-9830674 Formation of the ureteric bud 0.044013 1.356
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.014442 1.840
R-HSA-9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 0.257199 0.590
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.329922 0.482
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.215867 0.666
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.291550 0.535
R-HSA-9679191 Potential therapeutics for SARS 0.127692 0.894
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.116038 0.935
R-HSA-9018519 Estrogen-dependent gene expression 0.032056 1.494
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.228413 0.641
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.274010 0.562
R-HSA-3247509 Chromatin modifying enzymes 0.009322 2.030
R-HSA-157118 Signaling by NOTCH 0.178464 0.748
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.236806 0.626
R-HSA-948021 Transport to the Golgi and subsequent modification 0.247122 0.607
R-HSA-9007101 Rab regulation of trafficking 0.189848 0.722
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.010480 1.980
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.167160 0.777
R-HSA-9683610 Maturation of nucleoprotein 0.176632 0.753
R-HSA-9006931 Signaling by Nuclear Receptors 0.274822 0.561
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.276717 0.558
R-HSA-4839726 Chromatin organization 0.012801 1.893
R-HSA-9705683 SARS-CoV-2-host interactions 0.315288 0.501
R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.248650 0.604
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.118150 0.928
R-HSA-200425 Carnitine shuttle 0.282273 0.549
R-HSA-162582 Signal Transduction 0.106784 0.971
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.048636 1.313
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.306504 0.514
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.192725 0.715
R-HSA-68882 Mitotic Anaphase 0.135156 0.869
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.136857 0.864
R-HSA-8986944 Transcriptional Regulation by MECP2 0.316712 0.499
R-HSA-69242 S Phase 0.295266 0.530
R-HSA-9020591 Interleukin-12 signaling 0.072581 1.139
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.032121 1.493
R-HSA-9700206 Signaling by ALK in cancer 0.048636 1.313
R-HSA-8939211 ESR-mediated signaling 0.172783 0.762
R-HSA-373753 Nephrin family interactions 0.248650 0.604
R-HSA-1980143 Signaling by NOTCH1 0.249425 0.603
R-HSA-9659379 Sensory processing of sound 0.262064 0.582
R-HSA-9694631 Maturation of nucleoprotein 0.240002 0.620
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.195116 0.710
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.178458 0.748
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.190997 0.719
R-HSA-9730414 MITF-M-regulated melanocyte development 0.277081 0.557
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.204410 0.689
R-HSA-449836 Other interleukin signaling 0.240002 0.620
R-HSA-6806834 Signaling by MET 0.266279 0.575
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.262064 0.582
R-HSA-9768919 NPAS4 regulates expression of target genes 0.080603 1.094
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.080603 1.094
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.282273 0.549
R-HSA-9707564 Cytoprotection by HMOX1 0.087246 1.059
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.215867 0.666
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.314399 0.503
R-HSA-9830369 Kidney development 0.211699 0.674
R-HSA-9758941 Gastrulation 0.125724 0.901
R-HSA-2028269 Signaling by Hippo 0.222408 0.653
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.203388 0.692
R-HSA-73887 Death Receptor Signaling 0.313892 0.503
R-HSA-9679506 SARS-CoV Infections 0.338067 0.471
R-HSA-109581 Apoptosis 0.338766 0.470
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.345095 0.462
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.345095 0.462
R-HSA-162588 Budding and maturation of HIV virion 0.345095 0.462
R-HSA-182971 EGFR downregulation 0.345095 0.462
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.345095 0.462
R-HSA-9833109 Evasion by RSV of host interferon responses 0.345095 0.462
R-HSA-1538133 G0 and Early G1 0.352553 0.453
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.352553 0.453
R-HSA-422356 Regulation of insulin secretion 0.354044 0.451
R-HSA-69278 Cell Cycle, Mitotic 0.356937 0.447
R-HSA-193704 p75 NTR receptor-mediated signalling 0.358151 0.446
R-HSA-1855170 IPs transport between nucleus and cytosol 0.359926 0.444
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.359926 0.444
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.359926 0.444
R-HSA-1839124 FGFR1 mutant receptor activation 0.359926 0.444
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.359926 0.444
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.359926 0.444
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.359926 0.444
R-HSA-72306 tRNA processing 0.366685 0.436
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.367216 0.435
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.367216 0.435
R-HSA-2559580 Oxidative Stress Induced Senescence 0.370415 0.431
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.370415 0.431
R-HSA-1483255 PI Metabolism 0.370415 0.431
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.372867 0.428
R-HSA-5673000 RAF activation 0.374423 0.427
R-HSA-392518 Signal amplification 0.374423 0.427
R-HSA-180746 Nuclear import of Rev protein 0.374423 0.427
R-HSA-168638 NOD1/2 Signaling Pathway 0.374423 0.427
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.374423 0.427
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.374423 0.427
R-HSA-5689880 Ub-specific processing proteases 0.375954 0.425
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.378540 0.422
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.381549 0.418
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.381549 0.418
R-HSA-5619507 Activation of HOX genes during differentiation 0.382586 0.417
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.382586 0.417
R-HSA-5688426 Deubiquitination 0.384877 0.415
R-HSA-69205 G1/S-Specific Transcription 0.388594 0.411
R-HSA-74158 RNA Polymerase III Transcription 0.388594 0.411
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.388594 0.411
R-HSA-9682385 FLT3 signaling in disease 0.388594 0.411
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.388594 0.411
R-HSA-211000 Gene Silencing by RNA 0.394657 0.404
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.395559 0.403
R-HSA-5689896 Ovarian tumor domain proteases 0.395559 0.403
R-HSA-2559583 Cellular Senescence 0.397470 0.401
R-HSA-9006925 Intracellular signaling by second messengers 0.398081 0.400
R-HSA-6785470 tRNA processing in the mitochondrion 0.402445 0.395
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.402445 0.395
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.409254 0.388
R-HSA-9694516 SARS-CoV-2 Infection 0.413834 0.383
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.415985 0.381
R-HSA-451927 Interleukin-2 family signaling 0.415985 0.381
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.415985 0.381
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.415985 0.381
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.415985 0.381
R-HSA-177243 Interactions of Rev with host cellular proteins 0.415985 0.381
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.415985 0.381
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.415985 0.381
R-HSA-1251985 Nuclear signaling by ERBB4 0.415985 0.381
R-HSA-8868766 rRNA processing in the mitochondrion 0.415985 0.381
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.418470 0.378
R-HSA-74160 Gene expression (Transcription) 0.421600 0.375
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.422394 0.374
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.422639 0.374
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.422639 0.374
R-HSA-5655302 Signaling by FGFR1 in disease 0.429219 0.367
R-HSA-5675221 Negative regulation of MAPK pathway 0.429219 0.367
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.429219 0.367
R-HSA-6811438 Intra-Golgi traffic 0.429219 0.367
R-HSA-9683701 Translation of Structural Proteins 0.429219 0.367
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.433863 0.363
R-HSA-212436 Generic Transcription Pathway 0.435090 0.361
R-HSA-379716 Cytosolic tRNA aminoacylation 0.435724 0.361
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.435724 0.361
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.435724 0.361
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.435724 0.361
R-HSA-373760 L1CAM interactions 0.437950 0.359
R-HSA-8854214 TBC/RABGAPs 0.442155 0.354
R-HSA-5693538 Homology Directed Repair 0.445643 0.351
R-HSA-69236 G1 Phase 0.448513 0.348
R-HSA-69231 Cyclin D associated events in G1 0.448513 0.348
R-HSA-190828 Gap junction trafficking 0.448513 0.348
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.454799 0.342
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.454799 0.342
R-HSA-3371556 Cellular response to heat stress 0.457073 0.340
R-HSA-389948 Co-inhibition by PD-1 0.457681 0.339
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.461014 0.336
R-HSA-9839373 Signaling by TGFBR3 0.461014 0.336
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.461014 0.336
R-HSA-75153 Apoptotic execution phase 0.461014 0.336
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.464618 0.333
R-HSA-2132295 MHC class II antigen presentation 0.464618 0.333
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.467158 0.331
R-HSA-5620924 Intraflagellar transport 0.473232 0.325
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.473232 0.325
R-HSA-5357801 Programmed Cell Death 0.475268 0.323
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.475819 0.323
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.475819 0.323
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.475819 0.323
R-HSA-9766229 Degradation of CDH1 0.479238 0.319
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.479238 0.319
R-HSA-69481 G2/M Checkpoints 0.483207 0.316
R-HSA-68886 M Phase 0.489112 0.311
R-HSA-912446 Meiotic recombination 0.491046 0.309
R-HSA-1169091 Activation of NF-kappaB in B cells 0.491046 0.309
R-HSA-70895 Branched-chain amino acid catabolism 0.491046 0.309
R-HSA-2514856 The phototransduction cascade 0.491046 0.309
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.494169 0.306
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.495452 0.305
R-HSA-73857 RNA Polymerase II Transcription 0.496591 0.304
R-HSA-72187 mRNA 3'-end processing 0.496850 0.304
R-HSA-6794361 Neurexins and neuroligins 0.496850 0.304
R-HSA-1474165 Reproduction 0.497791 0.303
R-HSA-1221632 Meiotic synapsis 0.502588 0.299
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.502588 0.299
R-HSA-445355 Smooth Muscle Contraction 0.502588 0.299
R-HSA-9012852 Signaling by NOTCH3 0.513869 0.289
R-HSA-177929 Signaling by EGFR 0.519414 0.284
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.519414 0.284
R-HSA-75893 TNF signaling 0.519414 0.284
R-HSA-163685 Integration of energy metabolism 0.522675 0.282
R-HSA-9764561 Regulation of CDH1 Function 0.524896 0.280
R-HSA-2980766 Nuclear Envelope Breakdown 0.524896 0.280
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.524896 0.280
R-HSA-6807070 PTEN Regulation 0.533086 0.273
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.535674 0.271
R-HSA-9664407 Parasite infection 0.536521 0.270
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.536521 0.270
R-HSA-9664417 Leishmania phagocytosis 0.536521 0.270
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.539940 0.268
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.540972 0.267
R-HSA-1227986 Signaling by ERBB2 0.540972 0.267
R-HSA-8873719 RAB geranylgeranylation 0.540972 0.267
R-HSA-379724 tRNA Aminoacylation 0.540972 0.267
R-HSA-8943724 Regulation of PTEN gene transcription 0.540972 0.267
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.540972 0.267
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.540972 0.267
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.540972 0.267
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.540972 0.267
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.540972 0.267
R-HSA-73856 RNA Polymerase II Transcription Termination 0.546209 0.263
R-HSA-168325 Viral Messenger RNA Synthesis 0.546209 0.263
R-HSA-112043 PLC beta mediated events 0.546209 0.263
R-HSA-450294 MAP kinase activation 0.546209 0.263
R-HSA-162599 Late Phase of HIV Life Cycle 0.546725 0.262
R-HSA-8856828 Clathrin-mediated endocytosis 0.550091 0.260
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.551387 0.259
R-HSA-6784531 tRNA processing in the nucleus 0.551387 0.259
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.551387 0.259
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.556506 0.255
R-HSA-8848021 Signaling by PTK6 0.556506 0.255
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.561567 0.251
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.571518 0.243
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.571518 0.243
R-HSA-9856651 MITF-M-dependent gene expression 0.573165 0.242
R-HSA-5693606 DNA Double Strand Break Response 0.576408 0.239
R-HSA-112040 G-protein mediated events 0.576408 0.239
R-HSA-196807 Nicotinate metabolism 0.576408 0.239
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.579598 0.237
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.581243 0.236
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.585961 0.232
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.590750 0.229
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.590750 0.229
R-HSA-448424 Interleukin-17 signaling 0.590750 0.229
R-HSA-69202 Cyclin E associated events during G1/S transition 0.590750 0.229
R-HSA-162587 HIV Life Cycle 0.595372 0.225
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.595422 0.225
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.600041 0.222
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.600041 0.222
R-HSA-877300 Interferon gamma signaling 0.601557 0.221
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.604608 0.219
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.604608 0.219
R-HSA-1226099 Signaling by FGFR in disease 0.609123 0.215
R-HSA-388841 Regulation of T cell activation by CD28 family 0.612467 0.213
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.613587 0.212
R-HSA-71403 Citric acid cycle (TCA cycle) 0.613587 0.212
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.613587 0.212
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.617999 0.209
R-HSA-9694635 Translation of Structural Proteins 0.622362 0.206
R-HSA-383280 Nuclear Receptor transcription pathway 0.626676 0.203
R-HSA-6783783 Interleukin-10 signaling 0.626676 0.203
R-HSA-4086400 PCP/CE pathway 0.626676 0.203
R-HSA-73864 RNA Polymerase I Transcription 0.626676 0.203
R-HSA-416482 G alpha (12/13) signalling events 0.626676 0.203
R-HSA-73894 DNA Repair 0.633205 0.198
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.635156 0.197
R-HSA-9711123 Cellular response to chemical stress 0.641074 0.193
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.645686 0.190
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.645686 0.190
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.648487 0.188
R-HSA-597592 Post-translational protein modification 0.648765 0.188
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.651270 0.186
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.651545 0.186
R-HSA-6794362 Protein-protein interactions at synapses 0.655527 0.183
R-HSA-5687128 MAPK6/MAPK4 signaling 0.655527 0.183
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.659463 0.181
R-HSA-1266738 Developmental Biology 0.664245 0.178
R-HSA-438064 Post NMDA receptor activation events 0.667203 0.176
R-HSA-390466 Chaperonin-mediated protein folding 0.667203 0.176
R-HSA-9658195 Leishmania infection 0.670368 0.174
R-HSA-9824443 Parasitic Infection Pathways 0.670368 0.174
R-HSA-9663891 Selective autophagy 0.671006 0.173
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.678484 0.168
R-HSA-202424 Downstream TCR signaling 0.678484 0.168
R-HSA-69275 G2/M Transition 0.680746 0.167
R-HSA-453274 Mitotic G2-G2/M phases 0.685882 0.164
R-HSA-391251 Protein folding 0.689386 0.162
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.689386 0.162
R-HSA-5617833 Cilium Assembly 0.690951 0.161
R-HSA-1483257 Phospholipid metabolism 0.699931 0.155
R-HSA-9609690 HCMV Early Events 0.705758 0.151
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.705758 0.151
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.706744 0.151
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.706744 0.151
R-HSA-157579 Telomere Maintenance 0.710098 0.149
R-HSA-8878159 Transcriptional regulation by RUNX3 0.710098 0.149
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.713414 0.147
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.713414 0.147
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.713414 0.147
R-HSA-70171 Glycolysis 0.719933 0.143
R-HSA-1643685 Disease 0.721406 0.142
R-HSA-9020702 Interleukin-1 signaling 0.723137 0.141
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.726305 0.139
R-HSA-9842860 Regulation of endogenous retroelements 0.726305 0.139
R-HSA-111885 Opioid Signalling 0.732532 0.135
R-HSA-9860931 Response of endothelial cells to shear stress 0.732532 0.135
R-HSA-9833110 RSV-host interactions 0.735593 0.133
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.738618 0.132
R-HSA-1500931 Cell-Cell communication 0.740460 0.130
R-HSA-446203 Asparagine N-linked glycosylation 0.747491 0.126
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.747491 0.126
R-HSA-2672351 Stimuli-sensing channels 0.747491 0.126
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.750381 0.125
R-HSA-449147 Signaling by Interleukins 0.750884 0.124
R-HSA-112315 Transmission across Chemical Synapses 0.752973 0.123
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.753239 0.123
R-HSA-166166 MyD88-independent TLR4 cascade 0.753239 0.123
R-HSA-202403 TCR signaling 0.753239 0.123
R-HSA-418990 Adherens junctions interactions 0.757146 0.121
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.758856 0.120
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.758856 0.120
R-HSA-1483249 Inositol phosphate metabolism 0.758856 0.120
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.761617 0.118
R-HSA-8951664 Neddylation 0.763248 0.117
R-HSA-9855142 Cellular responses to mechanical stimuli 0.764347 0.117
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.769713 0.114
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.769713 0.114
R-HSA-909733 Interferon alpha/beta signaling 0.772350 0.112
R-HSA-162906 HIV Infection 0.775056 0.111
R-HSA-70326 Glucose metabolism 0.777535 0.109
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.782602 0.106
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.782602 0.106
R-HSA-1280218 Adaptive Immune System 0.783067 0.106
R-HSA-68875 Mitotic Prophase 0.785093 0.105
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.789989 0.102
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.789989 0.102
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.792395 0.101
R-HSA-162909 Host Interactions of HIV factors 0.794774 0.100
R-HSA-6798695 Neutrophil degranulation 0.798202 0.098
R-HSA-69206 G1/S Transition 0.799451 0.097
R-HSA-114608 Platelet degranulation 0.804022 0.095
R-HSA-9609646 HCMV Infection 0.815692 0.088
R-HSA-421270 Cell-cell junction organization 0.817301 0.088
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.819218 0.087
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.829350 0.081
R-HSA-9734767 Developmental Cell Lineages 0.835656 0.078
R-HSA-1632852 Macroautophagy 0.837047 0.077
R-HSA-913531 Interferon Signaling 0.842570 0.074
R-HSA-2871837 FCERI mediated NF-kB activation 0.844399 0.073
R-HSA-2262752 Cellular responses to stress 0.845161 0.073
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.847950 0.072
R-HSA-2187338 Visual phototransduction 0.849695 0.071
R-HSA-76002 Platelet activation, signaling and aggregation 0.851008 0.070
R-HSA-9824446 Viral Infection Pathways 0.851416 0.070
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.851420 0.070
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.853458 0.069
R-HSA-446728 Cell junction organization 0.856261 0.067
R-HSA-446652 Interleukin-1 family signaling 0.858127 0.066
R-HSA-69306 DNA Replication 0.859756 0.066
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.861345 0.065
R-HSA-392499 Metabolism of proteins 0.862176 0.064
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.862958 0.064
R-HSA-8953897 Cellular responses to stimuli 0.864067 0.063
R-HSA-9612973 Autophagy 0.864532 0.063
R-HSA-9610379 HCMV Late Events 0.866088 0.062
R-HSA-2408522 Selenoamino acid metabolism 0.876493 0.057
R-HSA-5619102 SLC transporter disorders 0.880702 0.055
R-HSA-5621481 C-type lectin receptors (CLRs) 0.887402 0.052
R-HSA-422475 Axon guidance 0.890185 0.051
R-HSA-9678108 SARS-CoV-1 Infection 0.892492 0.049
R-HSA-168255 Influenza Infection 0.897353 0.047
R-HSA-8957322 Metabolism of steroids 0.905632 0.043
R-HSA-983712 Ion channel transport 0.908570 0.042
R-HSA-168898 Toll-like Receptor Cascades 0.910663 0.041
R-HSA-1474244 Extracellular matrix organization 0.911592 0.040
R-HSA-9675108 Nervous system development 0.916387 0.038
R-HSA-112316 Neuronal System 0.920079 0.036
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.922255 0.035
R-HSA-376176 Signaling by ROBO receptors 0.922255 0.035
R-HSA-1483206 Glycerophospholipid biosynthesis 0.922255 0.035
R-HSA-397014 Muscle contraction 0.930763 0.031
R-HSA-1280215 Cytokine Signaling in Immune system 0.937204 0.028
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.943810 0.025
R-HSA-72312 rRNA processing 0.945099 0.025
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.946527 0.024
R-HSA-202733 Cell surface interactions at the vascular wall 0.948196 0.023
R-HSA-5619115 Disorders of transmembrane transporters 0.953877 0.021
R-HSA-109582 Hemostasis 0.955281 0.020
R-HSA-5663205 Infectious disease 0.960934 0.017
R-HSA-416476 G alpha (q) signalling events 0.962148 0.017
R-HSA-168249 Innate Immune System 0.974909 0.011
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.984577 0.007
R-HSA-196854 Metabolism of vitamins and cofactors 0.988215 0.005
R-HSA-168256 Immune System 0.989965 0.004
R-HSA-9824439 Bacterial Infection Pathways 0.991411 0.004
R-HSA-418594 G alpha (i) signalling events 0.992964 0.003
R-HSA-8978868 Fatty acid metabolism 0.992964 0.003
R-HSA-72766 Translation 0.994566 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.994999 0.002
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.995998 0.002
R-HSA-556833 Metabolism of lipids 0.996620 0.001
R-HSA-388396 GPCR downstream signalling 0.999050 0.000
R-HSA-372790 Signaling by GPCR 0.999616 0.000
R-HSA-9709957 Sensory Perception 0.999957 0.000
R-HSA-382551 Transport of small molecules 0.999993 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
BMPR1BBMPR1B 0.795 0.402 1 0.459
CK2A2CK2A2 0.795 0.381 1 0.368
CDC7CDC7 0.792 0.477 1 0.493
BMPR1ABMPR1A 0.792 0.450 1 0.515
MOSMOS 0.786 0.445 1 0.415
COTCOT 0.784 0.080 2 0.888
GRK7GRK7 0.780 0.263 1 0.295
CK2A1CK2A1 0.779 0.316 1 0.338
GRK6GRK6 0.778 0.294 1 0.341
GRK1GRK1 0.777 0.227 -2 0.738
ALK2ALK2 0.777 0.400 -2 0.840
ACVR2BACVR2B 0.776 0.321 -2 0.838
TGFBR1TGFBR1 0.774 0.214 -2 0.836
DSTYKDSTYK 0.772 0.042 2 0.877
FAM20CFAM20C 0.772 0.135 2 0.530
IKKAIKKA 0.772 0.081 -2 0.742
IKKBIKKB 0.770 -0.007 -2 0.734
ACVR2AACVR2A 0.769 0.247 -2 0.831
GCN2GCN2 0.767 -0.055 2 0.812
GRK5GRK5 0.766 0.192 -3 0.739
KISKIS 0.766 0.005 1 0.168
GRK4GRK4 0.766 0.122 -2 0.802
CLK3CLK3 0.763 0.063 1 0.283
IKKEIKKE 0.763 -0.099 1 0.184
PRPKPRPK 0.762 -0.015 -1 0.793
ATMATM 0.762 0.035 1 0.247
RAF1RAF1 0.761 -0.024 1 0.274
TBK1TBK1 0.761 -0.118 1 0.185
CAMK2GCAMK2G 0.761 0.033 2 0.809
BMPR2BMPR2 0.761 0.066 -2 0.875
ALK4ALK4 0.761 0.151 -2 0.852
NEK6NEK6 0.759 -0.044 -2 0.861
PIM3PIM3 0.757 0.025 -3 0.681
MTORMTOR 0.756 -0.135 1 0.197
PLK3PLK3 0.756 0.095 2 0.775
ULK2ULK2 0.754 -0.149 2 0.805
NEK7NEK7 0.754 -0.125 -3 0.691
PLK1PLK1 0.754 0.034 -2 0.823
TGFBR2TGFBR2 0.753 -0.010 -2 0.819
PDHK4PDHK4 0.752 -0.189 1 0.241
JNK3JNK3 0.752 -0.004 1 0.153
ATRATR 0.751 -0.077 1 0.224
PDHK1PDHK1 0.751 -0.139 1 0.234
ULK1ULK1 0.749 -0.123 -3 0.681
TTBK2TTBK2 0.749 -0.025 2 0.723
NDR2NDR2 0.749 -0.034 -3 0.678
CAMK1BCAMK1B 0.749 -0.063 -3 0.683
ERK5ERK5 0.748 -0.103 1 0.184
MLK1MLK1 0.748 -0.097 2 0.818
CDK8CDK8 0.748 -0.063 1 0.152
CAMK2BCAMK2B 0.748 0.069 2 0.768
MAPKAPK2MAPKAPK2 0.748 0.021 -3 0.553
CDK1CDK1 0.747 -0.033 1 0.140
JNK2JNK2 0.747 -0.019 1 0.135
HUNKHUNK 0.747 -0.099 2 0.847
BCKDKBCKDK 0.746 -0.106 -1 0.774
TLK2TLK2 0.746 0.009 1 0.202
NLKNLK 0.745 -0.137 1 0.203
PLK2PLK2 0.745 0.119 -3 0.792
P38GP38G 0.744 -0.035 1 0.108
DLKDLK 0.744 -0.089 1 0.240
PRKD1PRKD1 0.744 -0.070 -3 0.625
CDKL1CDKL1 0.743 -0.067 -3 0.639
PKN3PKN3 0.742 -0.094 -3 0.648
MARK4MARK4 0.742 -0.041 4 0.838
LATS1LATS1 0.741 0.069 -3 0.727
GRK2GRK2 0.741 0.009 -2 0.702
TSSK2TSSK2 0.741 -0.000 -5 0.774
P38DP38D 0.740 -0.019 1 0.123
CDK19CDK19 0.740 -0.075 1 0.138
RSK2RSK2 0.739 -0.033 -3 0.600
CHAK2CHAK2 0.739 -0.094 -1 0.739
YSK4YSK4 0.739 -0.079 1 0.208
GRK3GRK3 0.739 0.046 -2 0.655
LATS2LATS2 0.738 -0.039 -5 0.707
AMPKA1AMPKA1 0.738 -0.066 -3 0.655
NIKNIK 0.738 -0.162 -3 0.709
PIM1PIM1 0.738 -0.019 -3 0.607
BRAFBRAF 0.737 0.078 -4 0.794
ANKRD3ANKRD3 0.737 -0.143 1 0.223
MLK3MLK3 0.737 -0.064 2 0.750
TLK1TLK1 0.737 0.006 -2 0.844
NEK9NEK9 0.736 -0.209 2 0.848
CAMK2ACAMK2A 0.736 0.030 2 0.796
P38BP38B 0.736 -0.048 1 0.124
JNK1JNK1 0.736 -0.010 1 0.138
HIPK4HIPK4 0.736 -0.090 1 0.188
CDK3CDK3 0.736 -0.035 1 0.125
DAPK2DAPK2 0.736 -0.072 -3 0.689
MLK4MLK4 0.735 -0.055 2 0.726
RIPK3RIPK3 0.735 -0.202 3 0.539
CAMK2DCAMK2D 0.735 -0.090 -3 0.637
MST4MST4 0.734 -0.139 2 0.842
CAMLCKCAMLCK 0.734 -0.111 -2 0.755
SRPK1SRPK1 0.734 -0.069 -3 0.593
NUAK2NUAK2 0.734 -0.107 -3 0.646
DNAPKDNAPK 0.733 -0.080 1 0.154
NDR1NDR1 0.733 -0.117 -3 0.661
MAPKAPK3MAPKAPK3 0.733 -0.086 -3 0.577
MASTLMASTL 0.733 -0.237 -2 0.767
DYRK2DYRK2 0.733 -0.074 1 0.152
CDKL5CDKL5 0.732 -0.087 -3 0.622
P90RSKP90RSK 0.732 -0.071 -3 0.614
PKRPKR 0.732 -0.109 1 0.224
SKMLCKSKMLCK 0.732 -0.121 -2 0.745
ERK1ERK1 0.732 -0.067 1 0.120
MEK1MEK1 0.732 -0.099 2 0.862
CDK5CDK5 0.731 -0.065 1 0.171
MLK2MLK2 0.731 -0.184 2 0.832
PRP4PRP4 0.731 -0.001 -3 0.670
TSSK1TSSK1 0.730 -0.076 -3 0.678
PKCDPKCD 0.730 -0.114 2 0.805
PERKPERK 0.730 -0.053 -2 0.847
SMG1SMG1 0.730 -0.102 1 0.189
PRKD2PRKD2 0.730 -0.089 -3 0.565
AMPKA2AMPKA2 0.730 -0.079 -3 0.623
P70S6KBP70S6KB 0.730 -0.062 -3 0.615
CDK2CDK2 0.729 -0.078 1 0.161
RSK3RSK3 0.729 -0.080 -3 0.601
P38AP38A 0.729 -0.080 1 0.145
CDK13CDK13 0.728 -0.092 1 0.152
MEKK3MEKK3 0.728 -0.111 1 0.198
SRPK3SRPK3 0.728 -0.059 -3 0.577
CDK7CDK7 0.728 -0.097 1 0.166
WNK3WNK3 0.728 -0.273 1 0.212
PKN2PKN2 0.728 -0.162 -3 0.639
CDK17CDK17 0.728 -0.079 1 0.112
SRPK2SRPK2 0.727 -0.058 -3 0.523
NIM1NIM1 0.727 -0.139 3 0.598
DRAK1DRAK1 0.727 -0.094 1 0.215
ICKICK 0.726 -0.112 -3 0.663
WNK1WNK1 0.726 -0.227 -2 0.786
ERK2ERK2 0.726 -0.085 1 0.127
CHK1CHK1 0.726 -0.050 -3 0.655
CDK18CDK18 0.726 -0.083 1 0.127
HRIHRI 0.725 -0.135 -2 0.852
CK1ECK1E 0.725 -0.019 -3 0.466
RSK4RSK4 0.725 -0.018 -3 0.583
IRE2IRE2 0.725 -0.137 2 0.760
PLK4PLK4 0.725 -0.129 2 0.651
ALPHAK3ALPHAK3 0.725 0.314 -1 0.757
MARK2MARK2 0.725 -0.032 4 0.748
VRK2VRK2 0.724 -0.257 1 0.244
IRE1IRE1 0.724 -0.199 1 0.193
CLK2CLK2 0.724 0.003 -3 0.594
QSKQSK 0.724 -0.062 4 0.816
MSK2MSK2 0.724 -0.081 -3 0.569
CAMK4CAMK4 0.723 -0.142 -3 0.619
MARK3MARK3 0.723 -0.035 4 0.786
RIPK1RIPK1 0.723 -0.277 1 0.202
MEKK2MEKK2 0.723 -0.114 2 0.823
MEKK1MEKK1 0.723 -0.154 1 0.209
PINK1PINK1 0.722 -0.142 1 0.197
TTBK1TTBK1 0.722 -0.083 2 0.646
NUAK1NUAK1 0.721 -0.110 -3 0.605
HIPK2HIPK2 0.721 -0.069 1 0.126
ZAKZAK 0.721 -0.148 1 0.206
MST2MST2 0.720 -0.024 1 0.219
PAK1PAK1 0.720 -0.112 -2 0.650
BRSK1BRSK1 0.720 -0.082 -3 0.601
CDK12CDK12 0.720 -0.098 1 0.137
CK1G1CK1G1 0.720 -0.053 -3 0.515
DYRK4DYRK4 0.719 -0.060 1 0.138
PASKPASK 0.719 -0.017 -3 0.686
CK1DCK1D 0.719 -0.011 -3 0.416
PKACGPKACG 0.719 -0.119 -2 0.616
SIKSIK 0.719 -0.078 -3 0.572
GSK3AGSK3A 0.719 0.015 4 0.406
NEK2NEK2 0.719 -0.204 2 0.816
EEF2KEEF2K 0.718 0.041 3 0.661
MSK1MSK1 0.717 -0.066 -3 0.573
AURAAURA 0.717 -0.062 -2 0.485
CLK4CLK4 0.717 -0.080 -3 0.593
MARK1MARK1 0.717 -0.062 4 0.803
CHAK1CHAK1 0.717 -0.192 2 0.786
CDK16CDK16 0.716 -0.073 1 0.122
MEK5MEK5 0.715 -0.242 2 0.840
TAO3TAO3 0.715 -0.119 1 0.200
QIKQIK 0.714 -0.171 -3 0.627
GAKGAK 0.714 -0.053 1 0.243
MELKMELK 0.714 -0.161 -3 0.602
PAK3PAK3 0.714 -0.166 -2 0.656
PRKD3PRKD3 0.714 -0.112 -3 0.544
NEK5NEK5 0.713 -0.211 1 0.205
CAMKK1CAMKK1 0.713 -0.121 -2 0.743
PKCBPKCB 0.713 -0.133 2 0.752
AURCAURC 0.713 -0.083 -2 0.519
TAK1TAK1 0.713 -0.058 1 0.249
DYRK1BDYRK1B 0.713 -0.079 1 0.139
CLK1CLK1 0.712 -0.088 -3 0.554
CDK9CDK9 0.712 -0.122 1 0.152
PKACBPKACB 0.712 -0.065 -2 0.538
MAPKAPK5MAPKAPK5 0.712 -0.148 -3 0.534
HIPK1HIPK1 0.711 -0.096 1 0.154
PKCAPKCA 0.711 -0.144 2 0.741
PAK2PAK2 0.711 -0.145 -2 0.634
PRKXPRKX 0.711 -0.035 -3 0.502
DYRK1ADYRK1A 0.711 -0.092 1 0.177
PHKG1PHKG1 0.710 -0.191 -3 0.634
CK1A2CK1A2 0.710 -0.042 -3 0.409
PKCGPKCG 0.710 -0.154 2 0.750
NEK8NEK8 0.710 -0.165 2 0.823
BRSK2BRSK2 0.709 -0.155 -3 0.608
DCAMKL1DCAMKL1 0.709 -0.119 -3 0.593
MYLK4MYLK4 0.708 -0.115 -2 0.642
PAK6PAK6 0.708 -0.110 -2 0.574
GSK3BGSK3B 0.707 -0.036 4 0.397
CAMK1GCAMK1G 0.707 -0.127 -3 0.569
SGK3SGK3 0.707 -0.110 -3 0.564
PKCHPKCH 0.707 -0.168 2 0.738
MNK2MNK2 0.707 -0.166 -2 0.671
PIM2PIM2 0.706 -0.078 -3 0.560
AURBAURB 0.706 -0.101 -2 0.514
IRAK4IRAK4 0.705 -0.223 1 0.204
PKCZPKCZ 0.705 -0.189 2 0.787
SSTKSSTK 0.705 -0.075 4 0.807
CAMKK2CAMKK2 0.705 -0.136 -2 0.725
MST3MST3 0.705 -0.183 2 0.841
TTKTTK 0.704 0.050 -2 0.823
AKT2AKT2 0.704 -0.092 -3 0.507
SNRKSNRK 0.704 -0.218 2 0.690
TAO2TAO2 0.703 -0.157 2 0.856
CDK14CDK14 0.703 -0.118 1 0.134
MPSK1MPSK1 0.703 -0.155 1 0.187
MST1MST1 0.703 -0.117 1 0.188
DCAMKL2DCAMKL2 0.703 -0.131 -3 0.613
MNK1MNK1 0.702 -0.148 -2 0.685
WNK4WNK4 0.702 -0.241 -2 0.787
HIPK3HIPK3 0.702 -0.132 1 0.152
GCKGCK 0.701 -0.162 1 0.188
PKG2PKG2 0.701 -0.117 -2 0.547
NEK11NEK11 0.701 -0.257 1 0.188
LKB1LKB1 0.701 -0.176 -3 0.659
ERK7ERK7 0.701 -0.066 2 0.503
PDK1PDK1 0.700 -0.165 1 0.213
CDK6CDK6 0.700 -0.100 1 0.134
DYRK3DYRK3 0.700 -0.106 1 0.153
DAPK3DAPK3 0.699 -0.041 -3 0.617
CAMK1DCAMK1D 0.699 -0.073 -3 0.489
MINKMINK 0.699 -0.183 1 0.184
SMMLCKSMMLCK 0.699 -0.141 -3 0.626
TNIKTNIK 0.698 -0.140 3 0.646
P70S6KP70S6K 0.698 -0.095 -3 0.522
IRAK1IRAK1 0.698 -0.244 -1 0.678
CDK4CDK4 0.698 -0.100 1 0.130
PHKG2PHKG2 0.698 -0.182 -3 0.589
OSR1OSR1 0.697 -0.055 2 0.817
VRK1VRK1 0.697 -0.180 2 0.859
HGKHGK 0.697 -0.175 3 0.636
CDK10CDK10 0.696 -0.110 1 0.130
PDHK3_TYRPDHK3_TYR 0.696 0.174 4 0.867
AKT1AKT1 0.695 -0.104 -3 0.515
MAP3K15MAP3K15 0.694 -0.224 1 0.194
PKCTPKCT 0.694 -0.176 2 0.747
DAPK1DAPK1 0.693 -0.054 -3 0.595
PKACAPKACA 0.693 -0.082 -2 0.488
NEK4NEK4 0.693 -0.275 1 0.180
TXKTXK 0.693 0.173 1 0.341
MEK2MEK2 0.692 -0.179 2 0.831
RIPK2RIPK2 0.691 -0.233 1 0.193
EPHA6EPHA6 0.691 0.206 -1 0.883
EPHB2EPHB2 0.691 0.267 -1 0.868
EPHA4EPHA4 0.690 0.266 2 0.772
PDHK1_TYRPDHK1_TYR 0.690 0.125 -1 0.864
NEK1NEK1 0.690 -0.255 1 0.198
PAK5PAK5 0.689 -0.137 -2 0.491
EPHB4EPHB4 0.689 0.184 -1 0.869
PDHK4_TYRPDHK4_TYR 0.688 0.107 2 0.880
MAP2K6_TYRMAP2K6_TYR 0.688 0.119 -1 0.838
BLKBLK 0.688 0.167 -1 0.832
MEKK6MEKK6 0.688 -0.269 1 0.197
MAP2K4_TYRMAP2K4_TYR 0.688 0.112 -1 0.832
LRRK2LRRK2 0.688 -0.233 2 0.844
CK1ACK1A 0.687 -0.026 -3 0.353
PAK4PAK4 0.687 -0.122 -2 0.497
YSK1YSK1 0.687 -0.192 2 0.812
MAKMAK 0.687 -0.074 -2 0.637
SYKSYK 0.686 0.234 -1 0.825
HPK1HPK1 0.686 -0.208 1 0.173
SRMSSRMS 0.686 0.206 1 0.379
BMPR2_TYRBMPR2_TYR 0.685 0.022 -1 0.857
SBKSBK 0.685 -0.044 -3 0.395
KHS1KHS1 0.685 -0.182 1 0.176
SGK1SGK1 0.684 -0.069 -3 0.443
EPHB1EPHB1 0.684 0.176 1 0.359
LOKLOK 0.684 -0.206 -2 0.703
PBKPBK 0.684 -0.133 1 0.208
FYNFYN 0.684 0.132 -1 0.796
FERFER 0.684 0.188 1 0.378
EPHB3EPHB3 0.684 0.200 -1 0.858
CAMK1ACAMK1A 0.683 -0.095 -3 0.465
SLKSLK 0.683 -0.164 -2 0.652
BIKEBIKE 0.683 -0.086 1 0.197
CHK2CHK2 0.683 -0.112 -3 0.445
PKN1PKN1 0.682 -0.148 -3 0.519
LCKLCK 0.682 0.107 -1 0.818
KHS2KHS2 0.682 -0.162 1 0.171
YES1YES1 0.681 0.057 -1 0.808
STLK3STLK3 0.680 -0.117 1 0.189
BUB1BUB1 0.680 -0.108 -5 0.756
MOKMOK 0.680 -0.105 1 0.143
HCKHCK 0.680 0.072 -1 0.813
STK33STK33 0.679 -0.202 2 0.639
PKCIPKCI 0.679 -0.203 2 0.747
AKT3AKT3 0.679 -0.092 -3 0.451
MRCKAMRCKA 0.679 -0.118 -3 0.567
MAP2K7_TYRMAP2K7_TYR 0.679 -0.099 2 0.864
ASK1ASK1 0.678 -0.188 1 0.204
NEK3NEK3 0.678 -0.252 1 0.179
PKCEPKCE 0.678 -0.153 2 0.733
EPHA5EPHA5 0.678 0.230 2 0.755
EGFREGFR 0.678 0.039 1 0.209
FRKFRK 0.678 0.122 -1 0.832
YANK3YANK3 0.678 -0.050 2 0.412
EPHA7EPHA7 0.677 0.171 2 0.776
TESK1_TYRTESK1_TYR 0.677 -0.104 3 0.698
MRCKBMRCKB 0.677 -0.117 -3 0.542
ROCK2ROCK2 0.676 -0.122 -3 0.597
INSRRINSRR 0.675 0.015 3 0.549
PINK1_TYRPINK1_TYR 0.675 -0.140 1 0.247
CK1G3CK1G3 0.674 -0.024 -3 0.314
ITKITK 0.673 0.031 -1 0.776
TECTEC 0.673 0.093 -1 0.715
JAK3JAK3 0.672 -0.061 1 0.217
ABL2ABL2 0.672 -0.035 -1 0.786
CSF1RCSF1R 0.672 -0.086 3 0.563
EPHA8EPHA8 0.672 0.116 -1 0.844
RETRET 0.672 -0.157 1 0.210
PKMYT1_TYRPKMYT1_TYR 0.672 -0.164 3 0.658
FGRFGR 0.672 -0.065 1 0.245
MYO3AMYO3A 0.671 -0.173 1 0.174
BMXBMX 0.671 0.046 -1 0.702
LYNLYN 0.671 0.073 3 0.517
TAO1TAO1 0.670 -0.192 1 0.170
TYK2TYK2 0.670 -0.185 1 0.222
HASPINHASPIN 0.669 -0.131 -1 0.555
SRCSRC 0.669 0.043 -1 0.794
FLT1FLT1 0.669 -0.008 -1 0.874
TYRO3TYRO3 0.669 -0.069 3 0.578
PTK2PTK2 0.669 0.084 -1 0.850
KITKIT 0.668 -0.068 3 0.572
ABL1ABL1 0.668 -0.052 -1 0.777
AAK1AAK1 0.668 -0.074 1 0.156
MST1RMST1R 0.668 -0.165 3 0.589
DMPK1DMPK1 0.668 -0.108 -3 0.564
JAK2JAK2 0.668 -0.180 1 0.217
ROS1ROS1 0.668 -0.102 3 0.543
FGFR2FGFR2 0.667 -0.059 3 0.603
EPHA2EPHA2 0.667 0.129 -1 0.833
MYO3BMYO3B 0.667 -0.195 2 0.820
FLT3FLT3 0.667 -0.085 3 0.568
MERTKMERTK 0.667 0.014 3 0.572
EPHA3EPHA3 0.665 0.051 2 0.747
METMET 0.665 -0.043 3 0.558
ERBB2ERBB2 0.665 -0.055 1 0.229
PKG1PKG1 0.665 -0.131 -2 0.471
FGFR1FGFR1 0.664 -0.085 3 0.572
CRIKCRIK 0.664 -0.101 -3 0.514
FGFR4FGFR4 0.663 -0.012 -1 0.794
PTK6PTK6 0.662 0.003 -1 0.690
ROCK1ROCK1 0.662 -0.131 -3 0.559
BTKBTK 0.662 -0.035 -1 0.721
FGFR3FGFR3 0.662 -0.044 3 0.582
TEKTEK 0.661 -0.009 3 0.529
ERBB4ERBB4 0.661 0.019 1 0.246
NTRK1NTRK1 0.660 -0.071 -1 0.811
LIMK1_TYRLIMK1_TYR 0.660 -0.210 2 0.857
DDR1DDR1 0.659 -0.169 4 0.802
ALKALK 0.659 -0.028 3 0.511
CK1G2CK1G2 0.659 -0.022 -3 0.414
LIMK2_TYRLIMK2_TYR 0.659 -0.218 -3 0.713
PTK2BPTK2B 0.659 0.013 -1 0.748
NEK10_TYRNEK10_TYR 0.659 -0.167 1 0.167
LTKLTK 0.658 -0.039 3 0.540
KDRKDR 0.658 -0.126 3 0.541
NTRK3NTRK3 0.658 -0.071 -1 0.765
PDGFRBPDGFRB 0.657 -0.176 3 0.576
AXLAXL 0.656 -0.093 3 0.565
INSRINSR 0.656 -0.081 3 0.524
JAK1JAK1 0.656 -0.170 1 0.184
EPHA1EPHA1 0.656 -0.001 3 0.533
FLT4FLT4 0.655 -0.107 3 0.560
NTRK2NTRK2 0.655 -0.126 3 0.557
TNK2TNK2 0.654 -0.113 3 0.535
CSKCSK 0.654 -0.061 2 0.786
MATKMATK 0.651 -0.058 -1 0.717
TNNI3K_TYRTNNI3K_TYR 0.650 -0.157 1 0.203
PDGFRAPDGFRA 0.650 -0.212 3 0.571
IGF1RIGF1R 0.649 -0.048 3 0.487
YANK2YANK2 0.647 -0.064 2 0.428
ZAP70ZAP70 0.644 -0.010 -1 0.713
WEE1_TYRWEE1_TYR 0.643 -0.156 -1 0.683
MUSKMUSK 0.643 -0.119 1 0.188
FESFES 0.641 0.006 -1 0.683
TNK1TNK1 0.638 -0.246 3 0.558
DDR2DDR2 0.637 -0.153 3 0.538