Motif 55 (n=292)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1B0GTI1 | CCDC201 | S24 | ochoa | Coiled-coil domain-containing protein 201 | None |
| A6ND36 | FAM83G | S760 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O00139 | KIF2A | S604 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O00571 | DDX3X | S492 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14495 | PLPP3 | S19 | ochoa | Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:27694435, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:23591818, PubMed:27694435, PubMed:9607309). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818). {ECO:0000250|UniProtKB:Q99JY8, ECO:0000269|PubMed:23591818, ECO:0000269|PubMed:27694435, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349}.; FUNCTION: Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:20123964, PubMed:21569306). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:12660161, PubMed:16099422). {ECO:0000269|PubMed:12660161, ECO:0000269|PubMed:16099422, ECO:0000269|PubMed:20123964, ECO:0000269|PubMed:21569306}. |
| O14578 | CIT | S1432 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14613 | CDC42EP2 | S101 | ochoa | Cdc42 effector protein 2 (Binder of Rho GTPases 1) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| O14686 | KMT2D | S2019 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S3837 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14827 | RASGRF2 | S718 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O14936 | CASK | S51 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O14939 | PLD2 | S888 | ochoa | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15014 | ZNF609 | S491 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15027 | SEC16A | S1841 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15063 | GARRE1 | S956 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O15069 | NACAD | S1303 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O15197 | EPHB6 | S637 | ochoa | Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}. |
| O15400 | STX7 | S45 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15523 | DDX3Y | S490 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43182 | ARHGAP6 | S939 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43303 | CCP110 | S551 | ochoa | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O60307 | MAST3 | S146 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60711 | LPXN | S188 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O94916 | NFAT5 | S266 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94916 | NFAT5 | S434 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95196 | CSPG5 | S543 | ochoa | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}. |
| O95235 | KIF20A | S532 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95359 | TACC2 | S2359 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95487 | SEC24B | S1224 | ochoa | Protein transport protein Sec24B (SEC24-related protein B) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O95503 | CBX6 | S107 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95600 | KLF8 | S48 | psp | Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741) | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}. |
| O95873 | C6orf47 | S112 | ochoa | Uncharacterized protein C6orf47 (Protein G4) | None |
| P01042 | KNG1 | S275 | ochoa | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| P04150 | NR3C1 | S45 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P05023 | ATP1A1 | S722 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P06732 | CKM | S199 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P09327 | VIL1 | S219 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P09884 | POLA1 | S503 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P10636 | MAPT | S739 | ochoa|psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1808 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11308 | ERG | S215 | psp | Transcriptional regulator ERG (Transforming protein ERG) | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| P12277 | CKB | S199 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P12757 | SKIL | S514 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P13637 | ATP1A3 | S712 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P17097 | ZNF7 | S138 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P17535 | JUND | S90 | ochoa | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
| P17540 | CKMT2 | S233 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P17812 | CTPS1 | S210 | ochoa | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P20929 | NEB | S1275 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P25445 | FAS | S212 | ochoa | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}. |
| P30038 | ALDH4A1 | S410 | ochoa | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}. |
| P30304 | CDC25A | S116 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30304 | CDC25A | S261 | ochoa | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30305 | CDC25B | S160 | ochoa | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31629 | HIVEP2 | S769 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P36873 | PPP1CC | S177 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P37837 | TALDO1 | S256 | ochoa | Transaldolase (EC 2.2.1.2) | Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}. |
| P38936 | CDKN1A | S98 | ochoa|psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P39748 | FEN1 | S187 | psp | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P40818 | USP8 | S452 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P41229 | KDM5C | S897 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P42166 | TMPO | S370 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42345 | MTOR | S1166 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P43364 | MAGEA11 | S208 | ochoa|psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P46531 | NOTCH1 | S2121 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P46940 | IQGAP1 | S330 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48552 | NRIP1 | S671 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P49757 | NUMB | S425 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49959 | MRE11 | S165 | ochoa | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50406 | HTR6 | S350 | psp | 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6) | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:8522988}. |
| P50993 | ATP1A2 | S719 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51787 | KCNQ1 | S468 | ochoa|psp | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P51825 | AFF1 | S307 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P51956 | NEK3 | S355 | ochoa | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
| P51957 | NEK4 | S461 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P54821 | PRRX1 | S67 | ochoa | Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). {ECO:0000250|UniProtKB:P63013, ECO:0000269|PubMed:35589735}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}. |
| P54920 | NAPA | S195 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55735 | SEC13 | S254 | ochoa | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P60842 | EIF4A1 | S323 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P62136 | PPP1CA | S177 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S176 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| Q00610 | CLTC | S412 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q01201 | RELB | S37 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01484 | ANK2 | S2440 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01543 | FLI1 | S241 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q01826 | SATB1 | S313 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q03431 | PTH1R | S519 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q04656 | ATP7A | S339 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q06265 | EXOSC9 | S65 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q08J23 | NSUN2 | S139 | psp | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q09472 | EP300 | S90 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q09666 | AHNAK | S511 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S1405 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12802 | AKAP13 | S1282 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12955 | ANK3 | S4229 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13868 | EXOSC2 | S175 | ochoa | Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7. {ECO:0000269|PubMed:17545563}. |
| Q14159 | SPIDR | S826 | ochoa | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:27967308, ECO:0000269|PubMed:34697795}. |
| Q14240 | EIF4A2 | S324 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14258 | TRIM25 | S46 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14686 | NCOA6 | S884 | ochoa|psp | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14814 | MEF2D | S110 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15046 | KARS1 | S207 | psp | Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}. |
| Q15398 | DLGAP5 | S806 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15678 | PTPN14 | S594 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15750 | TAB1 | S438 | ochoa|psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647, ECO:0000269|PubMed:37832545}. |
| Q15772 | SPEG | S390 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15797 | SMAD1 | S132 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16513 | PKN2 | S302 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16643 | DBN1 | S142 | ochoa|psp | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q17R98 | ZNF827 | S477 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q17R98 | ZNF827 | S518 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q2KHM9 | KIAA0753 | S772 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q3KP31 | ZNF791 | S85 | ochoa | Zinc finger protein 791 | May be involved in transcriptional regulation. |
| Q3T8J9 | GON4L | S1009 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q52LA3 | LIN52 | S28 | ochoa|psp | Protein lin-52 homolog | None |
| Q53RE8 | ANKRD39 | S153 | ochoa | Ankyrin repeat domain-containing protein 39 | None |
| Q562E7 | WDR81 | S686 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5FBB7 | SGO1 | S256 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5GLZ8 | HERC4 | S180 | ochoa | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}. |
| Q5M775 | SPECC1 | S912 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5S007 | LRRK2 | S926 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5T0B9 | ZNF362 | S169 | ochoa | Zinc finger protein 362 | May be involved in transcriptional regulation. |
| Q5T1V6 | DDX59 | S578 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5T8A7 | PPP1R26 | S1079 | ochoa | Protein phosphatase 1 regulatory subunit 26 | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}. |
| Q5TH69 | ARFGEF3 | S2061 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5U5Q3 | MEX3C | S320 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5VT06 | CEP350 | S2206 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S909 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S214 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWN6 | TASOR2 | S219 | ochoa | Protein TASOR 2 | None |
| Q5VZL5 | ZMYM4 | S782 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q63HK5 | TSHZ3 | S463 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q6MZQ0 | PRR5L | S29 | ochoa | Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) | Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}. |
| Q6NTE8 | MRNIP | S193 | ochoa | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
| Q6P2H3 | CEP85 | S141 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6UB98 | ANKRD12 | S1799 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6W2J9 | BCOR | S423 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6W2J9 | BCOR | S1127 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6WCQ1 | MPRIP | S619 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6XZF7 | DNMBP | S496 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZNL6 | FGD5 | S633 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZSZ6 | TSHZ1 | S765 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q6ZUU3 | FOXL2NB | S35 | ochoa | FOXL2 neighbor protein | None |
| Q6ZVD8 | PHLPP2 | S1189 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q6ZW76 | ANKS3 | S225 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
| Q6ZWE6 | PLEKHM3 | S350 | ochoa | Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}. |
| Q711Q0 | CEFIP | S517 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q71F56 | MED13L | S826 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q76I76 | SSH2 | S236 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7KZI7 | MARK2 | S486 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L591 | DOK3 | S407 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7L622 | G2E3 | S320 | ochoa | G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269|PubMed:18511420}. |
| Q7Z2Z1 | TICRR | S820 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z591 | AKNA | S52 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86SQ0 | PHLDB2 | S82 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86T90 | KIAA1328 | S499 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86U70 | LDB1 | S381 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86V20 | SHLD2 | S70 | ochoa | Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. |
| Q86VQ1 | GLCCI1 | S303 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XA9 | HEATR5A | S1996 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YD1 | PTOV1 | S73 | ochoa | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
| Q86YP4 | GATAD2A | S598 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IUD6 | RNF135 | S184 | ochoa | E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135) | E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}. |
| Q8IVF2 | AHNAK2 | S4419 | ochoa | Protein AHNAK2 | None |
| Q8IVW6 | ARID3B | S165 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8IW35 | CEP97 | S825 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWE5 | PLEKHM2 | S559 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8IWQ3 | BRSK2 | S367 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
| Q8IX90 | SKA3 | S155 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IY22 | CMIP | S349 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8IY22 | CMIP | S377 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8IY92 | SLX4 | S169 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYH5 | ZZZ3 | S113 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IZ73 | RPUSD2 | S436 | ochoa | Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
| Q8IZC7 | ZNF101 | S180 | ochoa | Zinc finger protein 101 (Zinc finger protein HZF12) | May be involved in transcriptional regulation. |
| Q8IZD2 | KMT2E | S795 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8N1G1 | REXO1 | S794 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N3K9 | CMYA5 | S142 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N4N8 | KIF2B | S147 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N4X5 | AFAP1L2 | S213 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N4X5 | AFAP1L2 | S559 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5I9 | NOPCHAP1 | S66 | ochoa | NOP protein chaperone 1 | Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. {ECO:0000269|PubMed:33367824}. |
| Q8N9U0 | TC2N | S137 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8N9U0 | TC2N | S168 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8ND24 | RNF214 | S47 | ochoa | RING finger protein 214 | None |
| Q8ND56 | LSM14A | S183 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDX1 | PSD4 | S1020 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NDX5 | PHC3 | S272 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEA6 | GLIS3 | S24 | ochoa | Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) | Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. |
| Q8NEB9 | PIK3C3 | S244 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NFC6 | BOD1L1 | S1281 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFH5 | NUP35 | S259 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8NFY4 | SEMA6D | S734 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8NHY3 | GAS2L2 | S662 | ochoa | GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). {ECO:0000250|UniProtKB:Q5SSG4, ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}. |
| Q8TAV0 | FAM76A | S202 | ochoa | Protein FAM76A | None |
| Q8TC76 | FAM110B | S95 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TCD5 | NT5C | S100 | ochoa | 5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1) | Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. |
| Q8TDC3 | BRSK1 | S384 | ochoa | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. |
| Q8TEW8 | PARD3B | S364 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8WVV4 | POF1B | S98 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WWW8 | GAB3 | S273 | ochoa | GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3) | None |
| Q8WXX5 | DNAJC9 | S88 | ochoa | DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73) | Acts as a dual histone chaperone and heat shock co-chaperone (PubMed:33857403). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (PubMed:33857403). May also act as a histone co-chaperone together with TONSL (PubMed:33857403). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (PubMed:33857403). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (PubMed:17182002, PubMed:33857403). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (PubMed:33857403). Exhibits activity to assemble histones onto DNA in vitro (PubMed:33857403). {ECO:0000269|PubMed:17182002, ECO:0000269|PubMed:33857403}. |
| Q8WZ75 | ROBO4 | S657 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92608 | DOCK2 | S1780 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92615 | LARP4B | S488 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92681 | RSC1A1 | S493 | ochoa | Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1) | Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}. |
| Q92769 | HDAC2 | S347 | ochoa | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
| Q92797 | SYMPK | S870 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92844 | TANK | S129 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92858 | ATOH1 | S84 | ochoa | Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1) | Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P48985}. |
| Q92994 | BRF1 | S614 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96AQ1 | CCDC74A | S38 | ochoa | Coiled-coil domain-containing protein 74A | None |
| Q96CA5 | BIRC7 | S37 | ochoa | Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] | Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045). {ECO:0000269|PubMed:11024045, ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11865055, ECO:0000269|PubMed:16729033, ECO:0000269|PubMed:17294084}.; FUNCTION: [Isoform 1]: Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.; FUNCTION: [Isoform 2]: Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}. |
| Q96CX2 | KCTD12 | S176 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96D46 | NMD3 | S258 | ochoa | 60S ribosomal export protein NMD3 (hNMD3) | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. |
| Q96DR7 | ARHGEF26 | S80 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96DZ5 | CLIP3 | S402 | ochoa | CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) | Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}. |
| Q96FI4 | NEIL1 | S207 | ochoa|psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
| Q96G01 | BICD1 | S860 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96JB2 | COG3 | S212 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JH7 | VCPIP1 | S131 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96LY2 | CCDC74B | S38 | ochoa | Coiled-coil domain-containing protein 74B | None |
| Q96MT3 | PRICKLE1 | S353 | ochoa | Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}. |
| Q96Q42 | ALS2 | S492 | ochoa|psp | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96RS0 | TGS1 | S189 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99590 | SCAF11 | S608 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99717 | SMAD5 | S133 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q99990 | VGLL1 | S116 | ochoa | Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}. |
| Q9BPZ7 | MAPKAP1 | S270 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BRS8 | LARP6 | S451 | ochoa|psp | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BTX1 | NDC1 | S474 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BXL6 | CARD14 | S60 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BY66 | KDM5D | S884 | ochoa | Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630, ECO:0000269|PubMed:26747897, ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27427228, ECO:0000269|PubMed:27477906}. |
| Q9BYW2 | SETD2 | S624 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZA7 | PCDH11X | S932 | ochoa | Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) | Potential calcium-dependent cell-adhesion protein. |
| Q9BZA8 | PCDH11Y | S964 | ochoa | Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22) | Potential calcium-dependent cell-adhesion protein. |
| Q9BZR8 | BCL2L14 | S44 | ochoa | Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G) | Plays a role in apoptosis. |
| Q9C073 | FAM117A | S178 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0G0 | ZNF407 | S1262 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9C0H5 | ARHGAP39 | S432 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H2D6 | TRIOBP | S1796 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2P0 | ADNP | S709 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4M7 | PLEKHA4 | S613 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H714 | RUBCNL | S29 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9H7N4 | SCAF1 | S874 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7Z3 | NRDE2 | S341 | ochoa | Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) | Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. |
| Q9H869 | YY1AP1 | S466 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9HC52 | CBX8 | S352 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCH5 | SYTL2 | S344 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCH5 | SYTL2 | S493 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HD20 | ATP13A1 | S899 | ochoa | Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) | Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}. |
| Q9NPI6 | DCP1A | S180 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NQQ7 | SLC35C2 | S336 | ochoa | Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein) | May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}. |
| Q9NVI1 | FANCI | S407 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NWS9 | ZNF446 | S181 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NYD6 | HOXC10 | S61 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NZL9 | MAT2B | S282 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| Q9NZN5 | ARHGEF12 | S190 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Z0 | ZBTB4 | S391 | ochoa | Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) | Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}. |
| Q9P209 | CEP72 | S237 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9P242 | NYAP2 | S599 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P2D6 | FAM135A | S454 | ochoa | Protein FAM135A | None |
| Q9UBB6 | NCDN | S583 | ochoa | Neurochondrin | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269|PubMed:16945926, ECO:0000269|PubMed:33711248, ECO:0000305|PubMed:33711248}. |
| Q9UBZ4 | APEX2 | S349 | ochoa | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}. |
| Q9UDY2 | TJP2 | S130 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UID6 | ZNF639 | S88 | ochoa | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}. |
| Q9UIF8 | BAZ2B | S556 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UJV9 | DDX41 | S289 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKI2 | CDC42EP3 | S100 | ochoa | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| Q9UKK3 | PARP4 | S1434 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULD4 | BRPF3 | S713 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULD9 | ZNF608 | S549 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULJ3 | ZBTB21 | S516 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULL1 | PLEKHG1 | S108 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UPV0 | CEP164 | S430 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPW0 | FOXJ3 | S199 | ochoa | Forkhead box protein J3 | Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}. |
| Q9UQK1 | PPP1R3C | S293 | ochoa|psp | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}. |
| Q9Y2H9 | MAST1 | S1184 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I7 | PIKFYVE | S1754 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2X9 | ZNF281 | S160 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3R5 | DOP1B | S597 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y4B5 | MTCL1 | S1399 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S597 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y597 | KCTD3 | S653 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y6D9 | MAD1L1 | S428 | ochoa|psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| P13798 | APEH | S304 | Sugiyama | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}. |
| Q14204 | DYNC1H1 | S2410 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q86VP6 | CAND1 | S376 | Sugiyama | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| O43283 | MAP3K13 | S39 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| O60285 | NUAK1 | S325 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O95456 | PSMG1 | S186 | Sugiyama | Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| P31152 | MAPK4 | S196 | GPS6|ELM|iPTMNet|EPSD | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000085 | 4.069 |
| R-HSA-69275 | G2/M Transition | 0.000106 | 3.973 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000118 | 3.929 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000225 | 3.649 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000278 | 3.556 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000278 | 3.556 |
| R-HSA-1640170 | Cell Cycle | 0.000564 | 3.249 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.000685 | 3.164 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.000808 | 3.092 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.000808 | 3.092 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.000796 | 3.099 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.001380 | 2.860 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.002276 | 2.643 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.002303 | 2.638 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.002459 | 2.609 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.002763 | 2.559 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.003003 | 2.522 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.003792 | 2.421 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.003817 | 2.418 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.004533 | 2.344 |
| R-HSA-68877 | Mitotic Prometaphase | 0.004773 | 2.321 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.005357 | 2.271 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.005357 | 2.271 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.005326 | 2.274 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.005904 | 2.229 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.006909 | 2.161 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.006741 | 2.171 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.007201 | 2.143 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.006741 | 2.171 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.007259 | 2.139 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.007726 | 2.112 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.008857 | 2.053 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.008857 | 2.053 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.008342 | 2.079 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.008857 | 2.053 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.009514 | 2.022 |
| R-HSA-68882 | Mitotic Anaphase | 0.010172 | 1.993 |
| R-HSA-73887 | Death Receptor Signaling | 0.009705 | 2.013 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.010471 | 1.980 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.011364 | 1.944 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.010735 | 1.969 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.012856 | 1.891 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.011959 | 1.922 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.012336 | 1.909 |
| R-HSA-9909396 | Circadian clock | 0.012020 | 1.920 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.012292 | 1.910 |
| R-HSA-162582 | Signal Transduction | 0.012989 | 1.886 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.013266 | 1.877 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.015127 | 1.820 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.014935 | 1.826 |
| R-HSA-71288 | Creatine metabolism | 0.015127 | 1.820 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.015359 | 1.814 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.016479 | 1.783 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.016103 | 1.793 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.016103 | 1.793 |
| R-HSA-9707616 | Heme signaling | 0.015245 | 1.817 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.017054 | 1.768 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.018194 | 1.740 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.018867 | 1.724 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.018194 | 1.740 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.018268 | 1.738 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.018501 | 1.733 |
| R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 0.020224 | 1.694 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.021723 | 1.663 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.021723 | 1.663 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.021458 | 1.668 |
| R-HSA-68886 | M Phase | 0.020130 | 1.696 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.020331 | 1.692 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.022258 | 1.653 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.025291 | 1.597 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.026483 | 1.577 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.028613 | 1.543 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.028613 | 1.543 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.026759 | 1.573 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.026483 | 1.577 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.026759 | 1.573 |
| R-HSA-380287 | Centrosome maturation | 0.028971 | 1.538 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.030923 | 1.510 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.031558 | 1.501 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.032972 | 1.482 |
| R-HSA-9843745 | Adipogenesis | 0.032985 | 1.482 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.033817 | 1.471 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.033817 | 1.471 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.038421 | 1.415 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.035227 | 1.453 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.037967 | 1.421 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.034379 | 1.464 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.043018 | 1.366 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.047929 | 1.319 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.053032 | 1.275 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.041107 | 1.386 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.041107 | 1.386 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.046756 | 1.330 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.046756 | 1.330 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.049716 | 1.304 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.050486 | 1.297 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.049716 | 1.304 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.046756 | 1.330 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.043018 | 1.366 |
| R-HSA-1538133 | G0 and Early G1 | 0.043886 | 1.358 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.049908 | 1.302 |
| R-HSA-191859 | snRNP Assembly | 0.049908 | 1.302 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.049716 | 1.304 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.052766 | 1.278 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.045592 | 1.341 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.053032 | 1.275 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.052766 | 1.278 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.045592 | 1.341 |
| R-HSA-74160 | Gene expression (Transcription) | 0.052931 | 1.276 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.041495 | 1.382 |
| R-HSA-212436 | Generic Transcription Pathway | 0.045031 | 1.346 |
| R-HSA-4839726 | Chromatin organization | 0.052045 | 1.284 |
| R-HSA-5578775 | Ion homeostasis | 0.043516 | 1.361 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.052251 | 1.282 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.043886 | 1.358 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 0.059458 | 1.226 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 0.059458 | 1.226 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.055903 | 1.253 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.058318 | 1.234 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.059128 | 1.228 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.062438 | 1.205 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.059188 | 1.228 |
| R-HSA-69242 | S Phase | 0.056289 | 1.250 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.063778 | 1.195 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.058318 | 1.234 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.063778 | 1.195 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.058318 | 1.234 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.065344 | 1.185 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.062438 | 1.205 |
| R-HSA-5688426 | Deubiquitination | 0.058536 | 1.233 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.059188 | 1.228 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.059215 | 1.228 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.059215 | 1.228 |
| R-HSA-163560 | Triglyceride catabolism | 0.059128 | 1.228 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.065833 | 1.182 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.068651 | 1.163 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.069310 | 1.159 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.069310 | 1.159 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.069402 | 1.159 |
| R-HSA-69206 | G1/S Transition | 0.069643 | 1.157 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.070356 | 1.153 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.072549 | 1.139 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.072870 | 1.137 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.072870 | 1.137 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.072870 | 1.137 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.072870 | 1.137 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.077468 | 1.111 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.075182 | 1.124 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.083154 | 1.080 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.077468 | 1.111 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.085399 | 1.069 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.086420 | 1.063 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.074356 | 1.129 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.087175 | 1.060 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.083154 | 1.080 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.076509 | 1.116 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.087175 | 1.060 |
| R-HSA-5576891 | Cardiac conduction | 0.083330 | 1.079 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.075231 | 1.124 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.091836 | 1.037 |
| R-HSA-9679506 | SARS-CoV Infections | 0.085339 | 1.069 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.087892 | 1.056 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.092055 | 1.036 |
| R-HSA-373753 | Nephrin family interactions | 0.093372 | 1.030 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.095119 | 1.022 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.095852 | 1.018 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.097125 | 1.013 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.097125 | 1.013 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.097125 | 1.013 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.098231 | 1.008 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.098402 | 1.007 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.099087 | 1.004 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.099087 | 1.004 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.099692 | 1.001 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.099692 | 1.001 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.099692 | 1.001 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.099939 | 1.000 |
| R-HSA-75153 | Apoptotic execution phase | 0.099939 | 1.000 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.115390 | 0.938 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.115390 | 0.938 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.115390 | 0.938 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.115390 | 0.938 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.133287 | 0.875 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.112672 | 0.948 |
| R-HSA-429947 | Deadenylation of mRNA | 0.126057 | 0.899 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.114483 | 0.941 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.112607 | 0.948 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.130383 | 0.885 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.124766 | 0.904 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.126057 | 0.899 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.122254 | 0.913 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.115390 | 0.938 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.115390 | 0.938 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.107846 | 0.967 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.126057 | 0.899 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.112607 | 0.948 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.112607 | 0.948 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.132885 | 0.877 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.124766 | 0.904 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.133287 | 0.875 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.119317 | 0.923 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.108318 | 0.965 |
| R-HSA-3214842 | HDMs demethylate histones | 0.132885 | 0.877 |
| R-HSA-6807070 | PTEN Regulation | 0.102958 | 0.987 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.112672 | 0.948 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.126057 | 0.899 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.126057 | 0.899 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.126057 | 0.899 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.150824 | 0.822 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.150824 | 0.822 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.168006 | 0.775 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.168006 | 0.775 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.184842 | 0.733 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.184842 | 0.733 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.184842 | 0.733 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.201338 | 0.696 |
| R-HSA-196025 | Formation of annular gap junctions | 0.201338 | 0.696 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.201338 | 0.696 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.217501 | 0.663 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.217501 | 0.663 |
| R-HSA-190873 | Gap junction degradation | 0.217501 | 0.663 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.217501 | 0.663 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.217501 | 0.663 |
| R-HSA-68952 | DNA replication initiation | 0.233339 | 0.632 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.264061 | 0.578 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.264061 | 0.578 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.278958 | 0.554 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.278958 | 0.554 |
| R-HSA-69109 | Leading Strand Synthesis | 0.278958 | 0.554 |
| R-HSA-69091 | Polymerase switching | 0.278958 | 0.554 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.146781 | 0.833 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.293555 | 0.532 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.307857 | 0.512 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.335602 | 0.474 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.349055 | 0.457 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.349055 | 0.457 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.349055 | 0.457 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.227087 | 0.644 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.362237 | 0.441 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.163612 | 0.786 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.163612 | 0.786 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.163612 | 0.786 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.163612 | 0.786 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.163612 | 0.786 |
| R-HSA-3928664 | Ephrin signaling | 0.375153 | 0.426 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.387808 | 0.411 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.387808 | 0.411 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.400207 | 0.398 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.400207 | 0.398 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.400207 | 0.398 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.400207 | 0.398 |
| R-HSA-72649 | Translation initiation complex formation | 0.361526 | 0.442 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.376077 | 0.425 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.139795 | 0.855 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.390491 | 0.408 |
| R-HSA-5693538 | Homology Directed Repair | 0.284945 | 0.545 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.173535 | 0.761 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.201338 | 0.696 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.278958 | 0.554 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.321871 | 0.492 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.230695 | 0.637 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.264061 | 0.578 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.349055 | 0.457 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.168006 | 0.775 |
| R-HSA-8849473 | PTK6 Expression | 0.184842 | 0.733 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.264061 | 0.578 |
| R-HSA-69190 | DNA strand elongation | 0.182648 | 0.738 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.199032 | 0.701 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.294733 | 0.531 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.309717 | 0.509 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.169452 | 0.771 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.145069 | 0.838 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.264653 | 0.577 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.264061 | 0.578 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.220031 | 0.658 |
| R-HSA-437239 | Recycling pathway of L1 | 0.309717 | 0.509 |
| R-HSA-9930044 | Nuclear RNA decay | 0.189972 | 0.721 |
| R-HSA-201451 | Signaling by BMP | 0.146781 | 0.833 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.177392 | 0.751 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.276728 | 0.558 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.150824 | 0.822 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.201338 | 0.696 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.217501 | 0.663 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.233339 | 0.632 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.233339 | 0.632 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.233339 | 0.632 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.264061 | 0.578 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.278958 | 0.554 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.293555 | 0.532 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.293555 | 0.532 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.321871 | 0.492 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.375153 | 0.426 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.249602 | 0.603 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.354202 | 0.451 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.135157 | 0.869 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.253622 | 0.596 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.175367 | 0.756 |
| R-HSA-3322077 | Glycogen synthesis | 0.400207 | 0.398 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.278958 | 0.554 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.335602 | 0.474 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.368818 | 0.433 |
| R-HSA-9824272 | Somitogenesis | 0.294733 | 0.531 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.217501 | 0.663 |
| R-HSA-70688 | Proline catabolism | 0.278958 | 0.554 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.307857 | 0.512 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.335602 | 0.474 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.368818 | 0.433 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.164349 | 0.784 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.257126 | 0.590 |
| R-HSA-157118 | Signaling by NOTCH | 0.166317 | 0.779 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.168552 | 0.773 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.278958 | 0.554 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.177392 | 0.751 |
| R-HSA-199991 | Membrane Trafficking | 0.295501 | 0.529 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.150824 | 0.822 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.184842 | 0.733 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.201338 | 0.696 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.264061 | 0.578 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.349055 | 0.457 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.349055 | 0.457 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.168552 | 0.773 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.375153 | 0.426 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.150185 | 0.823 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.181408 | 0.741 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.309717 | 0.509 |
| R-HSA-9675135 | Diseases of DNA repair | 0.302232 | 0.520 |
| R-HSA-983189 | Kinesins | 0.163612 | 0.786 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.257126 | 0.590 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.400207 | 0.398 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.264653 | 0.577 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.139795 | 0.855 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 0.150824 | 0.822 |
| R-HSA-389542 | NADPH regeneration | 0.168006 | 0.775 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.184842 | 0.733 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.217501 | 0.663 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.264061 | 0.578 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.293555 | 0.532 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.175367 | 0.756 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.362237 | 0.441 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.387808 | 0.411 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.339469 | 0.469 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.390491 | 0.408 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.217501 | 0.663 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.278958 | 0.554 |
| R-HSA-9733709 | Cardiogenesis | 0.189972 | 0.721 |
| R-HSA-373760 | L1CAM interactions | 0.275930 | 0.559 |
| R-HSA-2559583 | Cellular Senescence | 0.224303 | 0.649 |
| R-HSA-164944 | Nef and signal transduction | 0.168006 | 0.775 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.248856 | 0.604 |
| R-HSA-1483148 | Synthesis of PG | 0.349055 | 0.457 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.362237 | 0.441 |
| R-HSA-3229121 | Glycogen storage diseases | 0.362237 | 0.441 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.375153 | 0.426 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.225351 | 0.647 |
| R-HSA-3214847 | HATs acetylate histones | 0.390195 | 0.409 |
| R-HSA-2262752 | Cellular responses to stress | 0.226741 | 0.644 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.173535 | 0.761 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.349055 | 0.457 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.362237 | 0.441 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.257126 | 0.590 |
| R-HSA-180786 | Extension of Telomeres | 0.397643 | 0.401 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.257737 | 0.589 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.201921 | 0.695 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.277593 | 0.557 |
| R-HSA-397014 | Muscle contraction | 0.199605 | 0.700 |
| R-HSA-8963676 | Intestinal absorption | 0.201338 | 0.696 |
| R-HSA-390666 | Serotonin receptors | 0.233339 | 0.632 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.349055 | 0.457 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.362237 | 0.441 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.362237 | 0.441 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.375153 | 0.426 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.272180 | 0.565 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.154569 | 0.811 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.138836 | 0.857 |
| R-HSA-5617833 | Cilium Assembly | 0.257582 | 0.589 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.210981 | 0.676 |
| R-HSA-9659379 | Sensory processing of sound | 0.263198 | 0.580 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.225351 | 0.647 |
| R-HSA-525793 | Myogenesis | 0.139795 | 0.855 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.153836 | 0.813 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.321871 | 0.492 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.173535 | 0.761 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.204236 | 0.690 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.364008 | 0.439 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.285175 | 0.545 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.388637 | 0.410 |
| R-HSA-70171 | Glycolysis | 0.193635 | 0.713 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.268674 | 0.571 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.335602 | 0.474 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.144318 | 0.841 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.375153 | 0.426 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.214738 | 0.668 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.264653 | 0.577 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.376077 | 0.425 |
| R-HSA-68875 | Mitotic Prophase | 0.294003 | 0.532 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.262498 | 0.581 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.199032 | 0.701 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.139795 | 0.855 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.278958 | 0.554 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.146781 | 0.833 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.293555 | 0.532 |
| R-HSA-416700 | Other semaphorin interactions | 0.321871 | 0.492 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.349055 | 0.457 |
| R-HSA-3371556 | Cellular response to heat stress | 0.145069 | 0.838 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.201338 | 0.696 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.217501 | 0.663 |
| R-HSA-2028269 | Signaling by Hippo | 0.362237 | 0.441 |
| R-HSA-983712 | Ion channel transport | 0.136939 | 0.863 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.335136 | 0.475 |
| R-HSA-381042 | PERK regulates gene expression | 0.212160 | 0.673 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.335023 | 0.475 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.289469 | 0.538 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.322858 | 0.491 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.146781 | 0.833 |
| R-HSA-5673000 | RAF activation | 0.204733 | 0.689 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.400207 | 0.398 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.318383 | 0.497 |
| R-HSA-70326 | Glucose metabolism | 0.280432 | 0.552 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.168135 | 0.774 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.387808 | 0.411 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.257126 | 0.590 |
| R-HSA-9824446 | Viral Infection Pathways | 0.321751 | 0.492 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.317186 | 0.499 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.274163 | 0.562 |
| R-HSA-162906 | HIV Infection | 0.392249 | 0.406 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.342653 | 0.465 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.204733 | 0.689 |
| R-HSA-163685 | Integration of energy metabolism | 0.381092 | 0.419 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.317186 | 0.499 |
| R-HSA-75893 | TNF signaling | 0.376077 | 0.425 |
| R-HSA-201556 | Signaling by ALK | 0.242086 | 0.616 |
| R-HSA-8979227 | Triglyceride metabolism | 0.158717 | 0.799 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.219613 | 0.658 |
| R-HSA-186712 | Regulation of beta-cell development | 0.397643 | 0.401 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.219613 | 0.658 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.375153 | 0.426 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.242086 | 0.616 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.404755 | 0.393 |
| R-HSA-1483255 | PI Metabolism | 0.406554 | 0.391 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.406554 | 0.391 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.406554 | 0.391 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.406554 | 0.391 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.412356 | 0.385 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.412356 | 0.385 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.412356 | 0.385 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.412356 | 0.385 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.417389 | 0.379 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.422783 | 0.374 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.422783 | 0.374 |
| R-HSA-9833110 | RSV-host interactions | 0.422783 | 0.374 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.424260 | 0.372 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.424260 | 0.372 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.424260 | 0.372 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.424260 | 0.372 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.424260 | 0.372 |
| R-HSA-8848021 | Signaling by PTK6 | 0.425845 | 0.371 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.425845 | 0.371 |
| R-HSA-373755 | Semaphorin interactions | 0.425845 | 0.371 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.435923 | 0.361 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.435923 | 0.361 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.435923 | 0.361 |
| R-HSA-8964038 | LDL clearance | 0.435923 | 0.361 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.435923 | 0.361 |
| R-HSA-211000 | Gene Silencing by RNA | 0.438859 | 0.358 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.439687 | 0.357 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.439687 | 0.357 |
| R-HSA-166520 | Signaling by NTRKs | 0.440236 | 0.356 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.446540 | 0.350 |
| R-HSA-200425 | Carnitine shuttle | 0.447351 | 0.349 |
| R-HSA-3000170 | Syndecan interactions | 0.447351 | 0.349 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.458548 | 0.339 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.460103 | 0.337 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.460103 | 0.337 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.462575 | 0.335 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.465261 | 0.332 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.469519 | 0.328 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.469519 | 0.328 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.469519 | 0.328 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.469519 | 0.328 |
| R-HSA-9839394 | TGFBR3 expression | 0.469519 | 0.328 |
| R-HSA-1989781 | PPARA activates gene expression | 0.471425 | 0.327 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.473471 | 0.325 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.473471 | 0.325 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.475670 | 0.323 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.475670 | 0.323 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.475933 | 0.322 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.480080 | 0.319 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.480221 | 0.319 |
| R-HSA-162587 | HIV Life Cycle | 0.480221 | 0.319 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.480268 | 0.319 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.480268 | 0.319 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.480268 | 0.319 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.480268 | 0.319 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.486638 | 0.313 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.490800 | 0.309 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.490800 | 0.309 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.491106 | 0.309 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.493144 | 0.307 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.499598 | 0.301 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.501119 | 0.300 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.501272 | 0.300 |
| R-HSA-109581 | Apoptosis | 0.501955 | 0.299 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.506316 | 0.296 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.511230 | 0.291 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.511230 | 0.291 |
| R-HSA-180024 | DARPP-32 events | 0.511230 | 0.291 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.512347 | 0.290 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.512347 | 0.290 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.521136 | 0.283 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.521136 | 0.283 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.521136 | 0.283 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.521136 | 0.283 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.521136 | 0.283 |
| R-HSA-4086400 | PCP/CE pathway | 0.524881 | 0.280 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.524881 | 0.280 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.530842 | 0.275 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.531132 | 0.275 |
| R-HSA-9833482 | PKR-mediated signaling | 0.537197 | 0.270 |
| R-HSA-72306 | tRNA processing | 0.540032 | 0.268 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.540352 | 0.267 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.540352 | 0.267 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.545684 | 0.263 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.545684 | 0.263 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.545684 | 0.263 |
| R-HSA-194138 | Signaling by VEGF | 0.545684 | 0.263 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.549670 | 0.260 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.549670 | 0.260 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.549670 | 0.260 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.549670 | 0.260 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.549670 | 0.260 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.553071 | 0.257 |
| R-HSA-390522 | Striated Muscle Contraction | 0.558799 | 0.253 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.558799 | 0.253 |
| R-HSA-2024101 | CS/DS degradation | 0.558799 | 0.253 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.558799 | 0.253 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.558799 | 0.253 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.558799 | 0.253 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.558799 | 0.253 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.560540 | 0.251 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.567744 | 0.246 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.567744 | 0.246 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.567744 | 0.246 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.567744 | 0.246 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.567744 | 0.246 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.567744 | 0.246 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.567744 | 0.246 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.576509 | 0.239 |
| R-HSA-168255 | Influenza Infection | 0.576585 | 0.239 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.578549 | 0.238 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.584064 | 0.234 |
| R-HSA-913531 | Interferon Signaling | 0.584064 | 0.234 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.584231 | 0.233 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.584231 | 0.233 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.585096 | 0.233 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.585096 | 0.233 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.585096 | 0.233 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.585096 | 0.233 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.593509 | 0.227 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.593509 | 0.227 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.593509 | 0.227 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.593509 | 0.227 |
| R-HSA-8948216 | Collagen chain trimerization | 0.593509 | 0.227 |
| R-HSA-73884 | Base Excision Repair | 0.600938 | 0.221 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.601752 | 0.221 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.601752 | 0.221 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.605579 | 0.218 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.609829 | 0.215 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.609829 | 0.215 |
| R-HSA-71336 | Pentose phosphate pathway | 0.609829 | 0.215 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.609829 | 0.215 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.617136 | 0.210 |
| R-HSA-9646399 | Aggrephagy | 0.617742 | 0.209 |
| R-HSA-8982491 | Glycogen metabolism | 0.617742 | 0.209 |
| R-HSA-3371568 | Attenuation phase | 0.617742 | 0.209 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.617742 | 0.209 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.617742 | 0.209 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.625495 | 0.204 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.625495 | 0.204 |
| R-HSA-1632852 | Macroautophagy | 0.627179 | 0.203 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.627542 | 0.202 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.633092 | 0.199 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.633092 | 0.199 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.633092 | 0.199 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.633092 | 0.199 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.633092 | 0.199 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.635589 | 0.197 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.640535 | 0.193 |
| R-HSA-165159 | MTOR signalling | 0.640535 | 0.193 |
| R-HSA-73928 | Depyrimidination | 0.640535 | 0.193 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.640535 | 0.193 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.640535 | 0.193 |
| R-HSA-9609690 | HCMV Early Events | 0.640907 | 0.193 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.643003 | 0.192 |
| R-HSA-1296071 | Potassium Channels | 0.643003 | 0.192 |
| R-HSA-9710421 | Defective pyroptosis | 0.647827 | 0.189 |
| R-HSA-73621 | Pyrimidine catabolism | 0.647827 | 0.189 |
| R-HSA-157579 | Telomere Maintenance | 0.648009 | 0.188 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.654972 | 0.184 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.654972 | 0.184 |
| R-HSA-69236 | G1 Phase | 0.654972 | 0.184 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.654972 | 0.184 |
| R-HSA-9907900 | Proteasome assembly | 0.654972 | 0.184 |
| R-HSA-190828 | Gap junction trafficking | 0.654972 | 0.184 |
| R-HSA-156581 | Methylation | 0.654972 | 0.184 |
| R-HSA-5683826 | Surfactant metabolism | 0.654972 | 0.184 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.654972 | 0.184 |
| R-HSA-73894 | DNA Repair | 0.659656 | 0.181 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.661972 | 0.179 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.661972 | 0.179 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.661972 | 0.179 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.661972 | 0.179 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.661972 | 0.179 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.661972 | 0.179 |
| R-HSA-9758941 | Gastrulation | 0.663977 | 0.178 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.668831 | 0.175 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.668831 | 0.175 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.668831 | 0.175 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.668831 | 0.175 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.668831 | 0.175 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.668831 | 0.175 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.672204 | 0.172 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.675551 | 0.170 |
| R-HSA-5357801 | Programmed Cell Death | 0.675634 | 0.170 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.675642 | 0.170 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.682135 | 0.166 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.685350 | 0.164 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.687007 | 0.163 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.688586 | 0.162 |
| R-HSA-73893 | DNA Damage Bypass | 0.688586 | 0.162 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.688586 | 0.162 |
| R-HSA-9675108 | Nervous system development | 0.689786 | 0.161 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.690578 | 0.161 |
| R-HSA-9612973 | Autophagy | 0.690729 | 0.161 |
| R-HSA-9610379 | HCMV Late Events | 0.694418 | 0.158 |
| R-HSA-109704 | PI3K Cascade | 0.694906 | 0.158 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.695037 | 0.158 |
| R-HSA-69239 | Synthesis of DNA | 0.699443 | 0.155 |
| R-HSA-912446 | Meiotic recombination | 0.701099 | 0.154 |
| R-HSA-9864848 | Complex IV assembly | 0.701099 | 0.154 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.703796 | 0.153 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.703796 | 0.153 |
| R-HSA-72187 | mRNA 3'-end processing | 0.707166 | 0.150 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.707166 | 0.150 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.707166 | 0.150 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.707166 | 0.150 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.712346 | 0.147 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.712346 | 0.147 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.713110 | 0.147 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.718934 | 0.143 |
| R-HSA-422475 | Axon guidance | 0.721888 | 0.142 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.724640 | 0.140 |
| R-HSA-5619102 | SLC transporter disorders | 0.729490 | 0.137 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.730231 | 0.137 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.731799 | 0.136 |
| R-HSA-112399 | IRS-mediated signalling | 0.735708 | 0.133 |
| R-HSA-1483166 | Synthesis of PA | 0.735708 | 0.133 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.736762 | 0.133 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.736762 | 0.133 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.739667 | 0.131 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.741075 | 0.130 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.741075 | 0.130 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.744500 | 0.128 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.744500 | 0.128 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.745807 | 0.127 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.746333 | 0.127 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.746333 | 0.127 |
| R-HSA-597592 | Post-translational protein modification | 0.750827 | 0.124 |
| R-HSA-379724 | tRNA Aminoacylation | 0.751484 | 0.124 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.751484 | 0.124 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.751484 | 0.124 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.756531 | 0.121 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.756531 | 0.121 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.756531 | 0.121 |
| R-HSA-450294 | MAP kinase activation | 0.756531 | 0.121 |
| R-HSA-1442490 | Collagen degradation | 0.756531 | 0.121 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.761476 | 0.118 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.761476 | 0.118 |
| R-HSA-73886 | Chromosome Maintenance | 0.762998 | 0.117 |
| R-HSA-1280218 | Adaptive Immune System | 0.763151 | 0.117 |
| R-HSA-8963743 | Digestion and absorption | 0.766321 | 0.116 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.771068 | 0.113 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.771068 | 0.113 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.771068 | 0.113 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.775718 | 0.110 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.775718 | 0.110 |
| R-HSA-195721 | Signaling by WNT | 0.778782 | 0.109 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.780275 | 0.108 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.781771 | 0.107 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.784739 | 0.105 |
| R-HSA-196807 | Nicotinate metabolism | 0.784739 | 0.105 |
| R-HSA-114608 | Platelet degranulation | 0.786941 | 0.104 |
| R-HSA-69481 | G2/M Checkpoints | 0.786941 | 0.104 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.789112 | 0.103 |
| R-HSA-5218859 | Regulated Necrosis | 0.789112 | 0.103 |
| R-HSA-448424 | Interleukin-17 signaling | 0.797596 | 0.098 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.797596 | 0.098 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.801709 | 0.096 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.801709 | 0.096 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.801709 | 0.096 |
| R-HSA-8978934 | Metabolism of cofactors | 0.801709 | 0.096 |
| R-HSA-9609646 | HCMV Infection | 0.802537 | 0.096 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.803343 | 0.095 |
| R-HSA-74259 | Purine catabolism | 0.805739 | 0.094 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.808735 | 0.092 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.813555 | 0.090 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.815974 | 0.088 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.817345 | 0.088 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.817345 | 0.088 |
| R-HSA-917937 | Iron uptake and transport | 0.817345 | 0.088 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.820279 | 0.086 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.824696 | 0.084 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.828260 | 0.082 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.828524 | 0.082 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.832331 | 0.080 |
| R-HSA-8957322 | Metabolism of steroids | 0.832508 | 0.080 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.835173 | 0.078 |
| R-HSA-6806834 | Signaling by MET | 0.835173 | 0.078 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.836374 | 0.078 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.838524 | 0.076 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.841808 | 0.075 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.845025 | 0.073 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.848177 | 0.072 |
| R-HSA-1500620 | Meiosis | 0.851265 | 0.070 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.851265 | 0.070 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.853606 | 0.069 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.853616 | 0.069 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.854290 | 0.068 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.855458 | 0.068 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.857254 | 0.067 |
| R-HSA-6798695 | Neutrophil degranulation | 0.858302 | 0.066 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.858451 | 0.066 |
| R-HSA-9663891 | Selective autophagy | 0.863003 | 0.064 |
| R-HSA-69306 | DNA Replication | 0.864853 | 0.063 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.868521 | 0.061 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.868521 | 0.061 |
| R-HSA-8951664 | Neddylation | 0.870723 | 0.060 |
| R-HSA-9711097 | Cellular response to starvation | 0.875305 | 0.058 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.876386 | 0.057 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.876386 | 0.057 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.876386 | 0.057 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.877058 | 0.057 |
| R-HSA-877300 | Interferon gamma signaling | 0.877304 | 0.057 |
| R-HSA-1474290 | Collagen formation | 0.881366 | 0.055 |
| R-HSA-1483257 | Phospholipid metabolism | 0.886056 | 0.053 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.886147 | 0.052 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.887499 | 0.052 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.892759 | 0.049 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.892959 | 0.049 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.892959 | 0.049 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.892959 | 0.049 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.892959 | 0.049 |
| R-HSA-422356 | Regulation of insulin secretion | 0.892959 | 0.049 |
| R-HSA-8953854 | Metabolism of RNA | 0.894294 | 0.049 |
| R-HSA-15869 | Metabolism of nucleotides | 0.895339 | 0.048 |
| R-HSA-168256 | Immune System | 0.895602 | 0.048 |
| R-HSA-8939211 | ESR-mediated signaling | 0.896821 | 0.047 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.897274 | 0.047 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.899094 | 0.046 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.899366 | 0.046 |
| R-HSA-418555 | G alpha (s) signalling events | 0.900738 | 0.045 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.902356 | 0.045 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.903950 | 0.044 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.903950 | 0.044 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.905390 | 0.043 |
| R-HSA-111885 | Opioid Signalling | 0.905390 | 0.043 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.905519 | 0.043 |
| R-HSA-1266738 | Developmental Biology | 0.905619 | 0.043 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.910632 | 0.041 |
| R-HSA-1500931 | Cell-Cell communication | 0.913185 | 0.039 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.914642 | 0.039 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.914642 | 0.039 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.916381 | 0.038 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.916381 | 0.038 |
| R-HSA-6803157 | Antimicrobial peptides | 0.919754 | 0.036 |
| R-HSA-3781865 | Diseases of glycosylation | 0.919950 | 0.036 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.921389 | 0.036 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.921389 | 0.036 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.922991 | 0.035 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.925122 | 0.034 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.926098 | 0.033 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.929080 | 0.032 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.929978 | 0.032 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.931943 | 0.031 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.934535 | 0.029 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.934690 | 0.029 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.934690 | 0.029 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.938604 | 0.028 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.938604 | 0.028 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.938812 | 0.027 |
| R-HSA-5663205 | Infectious disease | 0.939661 | 0.027 |
| R-HSA-8956319 | Nucleotide catabolism | 0.947937 | 0.023 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.948999 | 0.023 |
| R-HSA-1474165 | Reproduction | 0.950040 | 0.022 |
| R-HSA-9717189 | Sensory perception of taste | 0.951059 | 0.022 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.952058 | 0.021 |
| R-HSA-449147 | Signaling by Interleukins | 0.954491 | 0.020 |
| R-HSA-418990 | Adherens junctions interactions | 0.955750 | 0.020 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.958503 | 0.018 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.960181 | 0.018 |
| R-HSA-9664407 | Parasite infection | 0.960181 | 0.018 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.960181 | 0.018 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.960994 | 0.017 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.963335 | 0.016 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.964033 | 0.016 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.964084 | 0.016 |
| R-HSA-72312 | rRNA processing | 0.965260 | 0.015 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.969552 | 0.013 |
| R-HSA-168249 | Innate Immune System | 0.970112 | 0.013 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.971718 | 0.012 |
| R-HSA-112316 | Neuronal System | 0.972291 | 0.012 |
| R-HSA-421270 | Cell-cell junction organization | 0.975080 | 0.011 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.976237 | 0.010 |
| R-HSA-1643685 | Disease | 0.979657 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 0.982102 | 0.008 |
| R-HSA-611105 | Respiratory electron transport | 0.982573 | 0.008 |
| R-HSA-72766 | Translation | 0.982629 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.982871 | 0.008 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.983420 | 0.007 |
| R-HSA-446728 | Cell junction organization | 0.984562 | 0.007 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.985231 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.985319 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.985553 | 0.006 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.987223 | 0.006 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.987485 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.988016 | 0.005 |
| R-HSA-428157 | Sphingolipid metabolism | 0.989174 | 0.005 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.989613 | 0.005 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.989613 | 0.005 |
| R-HSA-72172 | mRNA Splicing | 0.990035 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 0.993806 | 0.003 |
| R-HSA-1474244 | Extracellular matrix organization | 0.994087 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.995079 | 0.002 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.995178 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996855 | 0.001 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.997072 | 0.001 |
| R-HSA-416476 | G alpha (q) signalling events | 0.997132 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.997507 | 0.001 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.997987 | 0.001 |
| R-HSA-9658195 | Leishmania infection | 0.997987 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998196 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.998294 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998587 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998587 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999188 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999704 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999988 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 1.000000 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.810 | 0.704 | 1 | 0.803 |
CDK17 |
0.809 | 0.698 | 1 | 0.837 |
CDK16 |
0.807 | 0.697 | 1 | 0.823 |
CDK3 |
0.798 | 0.538 | 1 | 0.829 |
P38G |
0.795 | 0.662 | 1 | 0.847 |
CDK19 |
0.793 | 0.614 | 1 | 0.785 |
KIS |
0.793 | 0.555 | 1 | 0.721 |
CDK14 |
0.792 | 0.691 | 1 | 0.759 |
P38D |
0.792 | 0.657 | 1 | 0.843 |
ERK1 |
0.792 | 0.647 | 1 | 0.782 |
JNK2 |
0.790 | 0.663 | 1 | 0.798 |
CDK7 |
0.789 | 0.626 | 1 | 0.749 |
CDK8 |
0.789 | 0.615 | 1 | 0.746 |
HIPK2 |
0.788 | 0.568 | 1 | 0.791 |
CDK1 |
0.787 | 0.590 | 1 | 0.780 |
CDK5 |
0.787 | 0.582 | 1 | 0.720 |
P38B |
0.786 | 0.642 | 1 | 0.764 |
DYRK4 |
0.783 | 0.598 | 1 | 0.798 |
DYRK2 |
0.782 | 0.579 | 1 | 0.695 |
CDK13 |
0.781 | 0.603 | 1 | 0.774 |
JNK3 |
0.781 | 0.648 | 1 | 0.768 |
CDK12 |
0.779 | 0.603 | 1 | 0.797 |
ERK2 |
0.779 | 0.651 | 1 | 0.728 |
CDK10 |
0.777 | 0.570 | 1 | 0.777 |
P38A |
0.775 | 0.616 | 1 | 0.689 |
CDK9 |
0.774 | 0.589 | 1 | 0.766 |
DYRK1B |
0.773 | 0.572 | 1 | 0.750 |
HIPK1 |
0.771 | 0.538 | 1 | 0.674 |
JNK1 |
0.771 | 0.587 | 1 | 0.800 |
CDK6 |
0.769 | 0.570 | 1 | 0.779 |
CDK4 |
0.769 | 0.590 | 1 | 0.807 |
CDK2 |
0.768 | 0.448 | 1 | 0.646 |
DYRK1A |
0.767 | 0.494 | 1 | 0.648 |
NLK |
0.767 | 0.576 | 1 | 0.464 |
HIPK4 |
0.764 | 0.349 | 1 | 0.468 |
HIPK3 |
0.764 | 0.520 | 1 | 0.644 |
ERK5 |
0.758 | 0.350 | 1 | 0.378 |
CLK3 |
0.757 | 0.306 | 1 | 0.425 |
DYRK3 |
0.756 | 0.433 | 1 | 0.637 |
SRPK1 |
0.752 | 0.216 | -3 | 0.719 |
CLK1 |
0.746 | 0.294 | -3 | 0.722 |
SRPK2 |
0.743 | 0.172 | -3 | 0.647 |
RIPK3 |
0.742 | 0.140 | 3 | 0.311 |
CDKL5 |
0.741 | 0.138 | -3 | 0.768 |
ICK |
0.741 | 0.281 | -3 | 0.801 |
MAK |
0.740 | 0.389 | -2 | 0.802 |
CLK4 |
0.740 | 0.267 | -3 | 0.740 |
MTOR |
0.740 | 0.128 | 1 | 0.253 |
CLK2 |
0.738 | 0.267 | -3 | 0.714 |
COT |
0.736 | -0.037 | 2 | 0.885 |
CDKL1 |
0.736 | 0.118 | -3 | 0.774 |
MOK |
0.735 | 0.362 | 1 | 0.560 |
SRPK3 |
0.732 | 0.141 | -3 | 0.692 |
TBK1 |
0.729 | -0.099 | 1 | 0.046 |
PRP4 |
0.729 | 0.337 | -3 | 0.730 |
CDC7 |
0.726 | -0.104 | 1 | 0.078 |
PRPK |
0.725 | -0.085 | -1 | 0.863 |
WNK1 |
0.724 | -0.037 | -2 | 0.880 |
RAF1 |
0.724 | -0.089 | 1 | 0.061 |
IKKE |
0.724 | -0.126 | 1 | 0.046 |
MOS |
0.724 | -0.043 | 1 | 0.121 |
MST4 |
0.723 | -0.017 | 2 | 0.868 |
ERK7 |
0.723 | 0.205 | 2 | 0.563 |
IRE2 |
0.722 | 0.002 | 2 | 0.797 |
NUAK2 |
0.721 | -0.009 | -3 | 0.806 |
WNK3 |
0.721 | -0.051 | 1 | 0.065 |
DSTYK |
0.721 | -0.077 | 2 | 0.884 |
PKN3 |
0.721 | -0.039 | -3 | 0.789 |
GCN2 |
0.721 | -0.172 | 2 | 0.797 |
CAMK1B |
0.721 | -0.036 | -3 | 0.835 |
ATR |
0.720 | -0.055 | 1 | 0.118 |
SKMLCK |
0.720 | 0.044 | -2 | 0.844 |
PDHK4 |
0.720 | -0.125 | 1 | 0.129 |
NIM1 |
0.719 | -0.021 | 3 | 0.193 |
NEK7 |
0.718 | -0.081 | -3 | 0.825 |
IRE1 |
0.718 | -0.054 | 1 | 0.069 |
CAMLCK |
0.718 | 0.012 | -2 | 0.831 |
ULK2 |
0.718 | -0.150 | 2 | 0.795 |
MLK1 |
0.717 | -0.073 | 2 | 0.836 |
PDHK1 |
0.717 | -0.134 | 1 | 0.107 |
BMPR2 |
0.717 | -0.145 | -2 | 0.874 |
PKN2 |
0.716 | -0.050 | -3 | 0.804 |
NEK6 |
0.716 | -0.081 | -2 | 0.850 |
NIK |
0.716 | -0.050 | -3 | 0.845 |
MARK4 |
0.715 | -0.050 | 4 | 0.893 |
NDR2 |
0.715 | -0.058 | -3 | 0.781 |
IKKB |
0.714 | -0.160 | -2 | 0.740 |
NDR1 |
0.714 | -0.047 | -3 | 0.788 |
PKCD |
0.714 | -0.035 | 2 | 0.814 |
TGFBR2 |
0.714 | -0.070 | -2 | 0.773 |
P90RSK |
0.713 | -0.013 | -3 | 0.743 |
PIM3 |
0.713 | -0.085 | -3 | 0.785 |
PRKD1 |
0.713 | -0.046 | -3 | 0.780 |
ATM |
0.713 | -0.018 | 1 | 0.090 |
DAPK2 |
0.712 | -0.011 | -3 | 0.836 |
NUAK1 |
0.712 | -0.019 | -3 | 0.757 |
RSK2 |
0.712 | -0.028 | -3 | 0.742 |
CAMK2G |
0.712 | -0.097 | 2 | 0.793 |
AMPKA1 |
0.711 | -0.063 | -3 | 0.813 |
HUNK |
0.711 | -0.137 | 2 | 0.807 |
RIPK1 |
0.711 | -0.107 | 1 | 0.057 |
PHKG1 |
0.711 | -0.038 | -3 | 0.780 |
ANKRD3 |
0.711 | -0.023 | 1 | 0.078 |
PRKD2 |
0.710 | -0.035 | -3 | 0.735 |
RSK3 |
0.710 | -0.029 | -3 | 0.736 |
NEK9 |
0.710 | -0.106 | 2 | 0.850 |
BCKDK |
0.710 | -0.103 | -1 | 0.807 |
CHAK2 |
0.709 | -0.105 | -1 | 0.846 |
ULK1 |
0.709 | -0.131 | -3 | 0.807 |
MLK3 |
0.708 | -0.040 | 2 | 0.769 |
AMPKA2 |
0.708 | -0.057 | -3 | 0.782 |
TSSK1 |
0.707 | -0.056 | -3 | 0.829 |
MELK |
0.707 | -0.044 | -3 | 0.772 |
MLK2 |
0.707 | -0.106 | 2 | 0.827 |
PIM1 |
0.707 | -0.026 | -3 | 0.743 |
P70S6KB |
0.706 | -0.029 | -3 | 0.768 |
MASTL |
0.706 | -0.118 | -2 | 0.816 |
MAPKAPK3 |
0.706 | -0.077 | -3 | 0.739 |
DNAPK |
0.706 | -0.041 | 1 | 0.118 |
QIK |
0.706 | -0.057 | -3 | 0.803 |
QSK |
0.705 | -0.038 | 4 | 0.882 |
TSSK2 |
0.705 | -0.082 | -5 | 0.870 |
PKCB |
0.705 | -0.041 | 2 | 0.774 |
PKCG |
0.704 | -0.038 | 2 | 0.768 |
PRKD3 |
0.704 | -0.019 | -3 | 0.717 |
VRK2 |
0.704 | 0.026 | 1 | 0.168 |
LATS2 |
0.703 | -0.066 | -5 | 0.800 |
BMPR1B |
0.702 | -0.051 | 1 | 0.052 |
PKCA |
0.702 | -0.037 | 2 | 0.762 |
SIK |
0.702 | -0.031 | -3 | 0.728 |
PKR |
0.702 | -0.078 | 1 | 0.085 |
PINK1 |
0.702 | 0.095 | 1 | 0.286 |
CAMK4 |
0.701 | -0.087 | -3 | 0.783 |
IRAK4 |
0.701 | -0.045 | 1 | 0.048 |
GRK5 |
0.701 | -0.176 | -3 | 0.820 |
GRK6 |
0.701 | -0.142 | 1 | 0.060 |
MAPKAPK2 |
0.701 | -0.068 | -3 | 0.691 |
PKCZ |
0.701 | -0.060 | 2 | 0.801 |
ALK4 |
0.701 | -0.053 | -2 | 0.813 |
IKKA |
0.701 | -0.128 | -2 | 0.738 |
PHKG2 |
0.701 | -0.045 | -3 | 0.772 |
WNK4 |
0.701 | -0.050 | -2 | 0.879 |
PKCH |
0.700 | -0.053 | 2 | 0.759 |
PAK3 |
0.700 | -0.061 | -2 | 0.765 |
CAMK2D |
0.700 | -0.105 | -3 | 0.806 |
MYLK4 |
0.700 | -0.017 | -2 | 0.738 |
MLK4 |
0.700 | -0.061 | 2 | 0.740 |
MNK2 |
0.700 | -0.054 | -2 | 0.776 |
GRK1 |
0.700 | -0.078 | -2 | 0.755 |
PAK6 |
0.700 | -0.021 | -2 | 0.689 |
TGFBR1 |
0.700 | -0.058 | -2 | 0.789 |
PKACG |
0.699 | -0.062 | -2 | 0.705 |
MARK2 |
0.699 | -0.032 | 4 | 0.813 |
MPSK1 |
0.699 | 0.009 | 1 | 0.142 |
MARK3 |
0.699 | -0.040 | 4 | 0.845 |
SNRK |
0.699 | -0.102 | 2 | 0.686 |
CAMK1G |
0.698 | -0.031 | -3 | 0.736 |
DLK |
0.698 | -0.223 | 1 | 0.074 |
AURC |
0.698 | -0.029 | -2 | 0.624 |
PLK1 |
0.698 | -0.102 | -2 | 0.795 |
SMG1 |
0.697 | -0.074 | 1 | 0.108 |
MNK1 |
0.697 | -0.039 | -2 | 0.776 |
NEK2 |
0.697 | -0.090 | 2 | 0.824 |
PAK1 |
0.697 | -0.059 | -2 | 0.766 |
TTBK2 |
0.697 | -0.152 | 2 | 0.695 |
MEKK1 |
0.697 | -0.045 | 1 | 0.074 |
FAM20C |
0.697 | -0.034 | 2 | 0.563 |
MSK2 |
0.696 | -0.051 | -3 | 0.705 |
CHAK1 |
0.696 | -0.145 | 2 | 0.768 |
BRSK2 |
0.696 | -0.091 | -3 | 0.779 |
PLK4 |
0.696 | -0.068 | 2 | 0.628 |
YSK4 |
0.696 | -0.144 | 1 | 0.050 |
AURB |
0.696 | -0.023 | -2 | 0.621 |
LATS1 |
0.695 | -0.036 | -3 | 0.792 |
SGK3 |
0.695 | -0.022 | -3 | 0.729 |
AKT2 |
0.695 | -0.004 | -3 | 0.666 |
GSK3A |
0.695 | 0.115 | 4 | 0.416 |
MEK1 |
0.695 | -0.117 | 2 | 0.823 |
ACVR2B |
0.695 | -0.062 | -2 | 0.774 |
PKCT |
0.695 | -0.042 | 2 | 0.766 |
GRK7 |
0.694 | -0.069 | 1 | 0.096 |
MARK1 |
0.693 | -0.061 | 4 | 0.864 |
DRAK1 |
0.693 | -0.114 | 1 | 0.042 |
PAK2 |
0.693 | -0.062 | -2 | 0.749 |
BRSK1 |
0.693 | -0.085 | -3 | 0.752 |
RSK4 |
0.693 | -0.033 | -3 | 0.700 |
ACVR2A |
0.693 | -0.074 | -2 | 0.764 |
SMMLCK |
0.693 | 0.019 | -3 | 0.790 |
MST3 |
0.692 | -0.040 | 2 | 0.856 |
NEK5 |
0.692 | -0.048 | 1 | 0.060 |
PKG2 |
0.692 | -0.037 | -2 | 0.637 |
MAPKAPK5 |
0.692 | -0.077 | -3 | 0.695 |
PIM2 |
0.691 | -0.016 | -3 | 0.723 |
ZAK |
0.691 | -0.101 | 1 | 0.059 |
HRI |
0.691 | -0.119 | -2 | 0.829 |
GRK4 |
0.691 | -0.167 | -2 | 0.785 |
CAMK2B |
0.691 | -0.091 | 2 | 0.751 |
MEKK3 |
0.691 | -0.091 | 1 | 0.070 |
MEKK2 |
0.690 | -0.065 | 2 | 0.816 |
CAMK2A |
0.690 | -0.074 | 2 | 0.772 |
PKCI |
0.690 | -0.035 | 2 | 0.775 |
MSK1 |
0.690 | -0.039 | -3 | 0.714 |
MEK5 |
0.689 | -0.107 | 2 | 0.825 |
CHK1 |
0.689 | -0.072 | -3 | 0.786 |
ALK2 |
0.689 | -0.082 | -2 | 0.792 |
PKN1 |
0.689 | -0.022 | -3 | 0.706 |
DCAMKL1 |
0.689 | -0.052 | -3 | 0.745 |
PLK3 |
0.689 | -0.116 | 2 | 0.746 |
BMPR1A |
0.688 | -0.056 | 1 | 0.044 |
PKACB |
0.687 | -0.032 | -2 | 0.640 |
AKT1 |
0.687 | -0.018 | -3 | 0.679 |
NEK11 |
0.687 | -0.059 | 1 | 0.089 |
SSTK |
0.687 | -0.069 | 4 | 0.873 |
PERK |
0.686 | -0.141 | -2 | 0.815 |
IRAK1 |
0.686 | -0.099 | -1 | 0.761 |
BRAF |
0.686 | -0.072 | -4 | 0.809 |
DCAMKL2 |
0.686 | -0.047 | -3 | 0.776 |
GRK2 |
0.685 | -0.078 | -2 | 0.673 |
TLK2 |
0.685 | -0.162 | 1 | 0.059 |
PKCE |
0.685 | -0.023 | 2 | 0.759 |
NEK4 |
0.684 | -0.055 | 1 | 0.051 |
TAO3 |
0.684 | -0.087 | 1 | 0.096 |
CK2A2 |
0.683 | -0.099 | 1 | 0.045 |
P70S6K |
0.683 | -0.034 | -3 | 0.689 |
CK1E |
0.683 | -0.032 | -3 | 0.519 |
GAK |
0.683 | -0.035 | 1 | 0.120 |
PAK5 |
0.682 | -0.040 | -2 | 0.625 |
MEKK6 |
0.682 | -0.049 | 1 | 0.073 |
TAO2 |
0.682 | -0.068 | 2 | 0.864 |
PAK4 |
0.682 | -0.026 | -2 | 0.633 |
RIPK2 |
0.682 | -0.097 | 1 | 0.045 |
AURA |
0.681 | -0.054 | -2 | 0.592 |
NEK8 |
0.681 | -0.100 | 2 | 0.839 |
PDK1 |
0.681 | -0.059 | 1 | 0.105 |
TTBK1 |
0.680 | -0.111 | 2 | 0.618 |
TLK1 |
0.680 | -0.149 | -2 | 0.800 |
GSK3B |
0.680 | 0.007 | 4 | 0.408 |
DAPK3 |
0.679 | -0.005 | -3 | 0.760 |
MAP3K15 |
0.679 | -0.078 | 1 | 0.073 |
PRKX |
0.679 | -0.027 | -3 | 0.639 |
PASK |
0.678 | -0.085 | -3 | 0.799 |
CHK2 |
0.676 | -0.019 | -3 | 0.616 |
CAMK1D |
0.676 | -0.045 | -3 | 0.653 |
NEK1 |
0.676 | -0.066 | 1 | 0.045 |
HGK |
0.675 | -0.100 | 3 | 0.144 |
CK2A1 |
0.675 | -0.102 | 1 | 0.039 |
PKACA |
0.674 | -0.032 | -2 | 0.585 |
TNIK |
0.674 | -0.084 | 3 | 0.147 |
CK1D |
0.674 | -0.018 | -3 | 0.468 |
MINK |
0.673 | -0.113 | 1 | 0.051 |
SBK |
0.673 | 0.063 | -3 | 0.555 |
CK1G1 |
0.673 | -0.069 | -3 | 0.503 |
GCK |
0.673 | -0.119 | 1 | 0.075 |
EEF2K |
0.673 | -0.122 | 3 | 0.111 |
MST2 |
0.673 | -0.097 | 1 | 0.057 |
VRK1 |
0.672 | -0.142 | 2 | 0.871 |
CK1A2 |
0.672 | -0.031 | -3 | 0.470 |
AKT3 |
0.672 | -0.013 | -3 | 0.599 |
HASPIN |
0.672 | -0.006 | -1 | 0.684 |
CAMK1A |
0.672 | -0.025 | -3 | 0.627 |
NEK3 |
0.672 | -0.046 | 1 | 0.077 |
LKB1 |
0.672 | -0.101 | -3 | 0.799 |
LRRK2 |
0.672 | -0.067 | 2 | 0.852 |
SGK1 |
0.671 | 0.004 | -3 | 0.586 |
KHS1 |
0.671 | -0.086 | 1 | 0.071 |
DAPK1 |
0.671 | -0.034 | -3 | 0.746 |
TTK |
0.670 | 0.067 | -2 | 0.802 |
MRCKB |
0.670 | -0.024 | -3 | 0.710 |
HPK1 |
0.670 | -0.103 | 1 | 0.077 |
LOK |
0.670 | -0.091 | -2 | 0.759 |
BUB1 |
0.670 | -0.046 | -5 | 0.830 |
KHS2 |
0.669 | -0.077 | 1 | 0.082 |
CAMKK1 |
0.669 | -0.189 | -2 | 0.782 |
YSK1 |
0.668 | -0.094 | 2 | 0.830 |
PBK |
0.667 | -0.050 | 1 | 0.107 |
ROCK2 |
0.667 | -0.029 | -3 | 0.747 |
CAMKK2 |
0.667 | -0.151 | -2 | 0.778 |
MRCKA |
0.667 | -0.037 | -3 | 0.720 |
GRK3 |
0.667 | -0.092 | -2 | 0.621 |
BIKE |
0.666 | -0.025 | 1 | 0.122 |
DMPK1 |
0.665 | 0.009 | -3 | 0.729 |
TAK1 |
0.665 | -0.159 | 1 | 0.050 |
MST1 |
0.664 | -0.136 | 1 | 0.050 |
PLK2 |
0.662 | -0.078 | -3 | 0.770 |
AAK1 |
0.662 | -0.002 | 1 | 0.140 |
MEK2 |
0.661 | -0.143 | 2 | 0.802 |
PKG1 |
0.661 | -0.040 | -2 | 0.550 |
STK33 |
0.660 | -0.134 | 2 | 0.598 |
SLK |
0.660 | -0.109 | -2 | 0.700 |
CSF1R |
0.659 | 0.100 | 3 | 0.258 |
PDHK3_TYR |
0.659 | 0.042 | 4 | 0.904 |
ROCK1 |
0.658 | -0.025 | -3 | 0.721 |
CRIK |
0.658 | -0.005 | -3 | 0.675 |
KDR |
0.658 | 0.148 | 3 | 0.298 |
MST1R |
0.658 | 0.094 | 3 | 0.240 |
PKMYT1_TYR |
0.658 | 0.097 | 3 | 0.166 |
TAO1 |
0.657 | -0.082 | 1 | 0.071 |
BLK |
0.656 | 0.120 | -1 | 0.887 |
JAK1 |
0.656 | 0.096 | 1 | 0.073 |
ASK1 |
0.656 | -0.090 | 1 | 0.074 |
MYO3A |
0.656 | -0.062 | 1 | 0.074 |
ROS1 |
0.655 | 0.026 | 3 | 0.220 |
MYO3B |
0.654 | -0.081 | 2 | 0.840 |
JAK2 |
0.654 | 0.023 | 1 | 0.099 |
LIMK2_TYR |
0.654 | 0.046 | -3 | 0.854 |
FGFR1 |
0.653 | 0.103 | 3 | 0.244 |
TEK |
0.653 | 0.096 | 3 | 0.219 |
FGFR2 |
0.653 | 0.115 | 3 | 0.249 |
TESK1_TYR |
0.652 | -0.039 | 3 | 0.147 |
TNK2 |
0.652 | 0.090 | 3 | 0.295 |
YES1 |
0.651 | 0.009 | -1 | 0.877 |
JAK3 |
0.651 | 0.050 | 1 | 0.084 |
EPHA6 |
0.651 | 0.030 | -1 | 0.902 |
LCK |
0.651 | 0.046 | -1 | 0.883 |
PDHK4_TYR |
0.650 | -0.013 | 2 | 0.866 |
OSR1 |
0.650 | -0.131 | 2 | 0.798 |
RET |
0.650 | -0.057 | 1 | 0.090 |
TYK2 |
0.650 | -0.050 | 1 | 0.077 |
ALPHAK3 |
0.649 | -0.067 | -1 | 0.787 |
INSRR |
0.649 | 0.023 | 3 | 0.234 |
PINK1_TYR |
0.647 | -0.096 | 1 | 0.121 |
MAP2K7_TYR |
0.647 | -0.109 | 2 | 0.852 |
TYRO3 |
0.647 | -0.054 | 3 | 0.193 |
BMPR2_TYR |
0.647 | -0.009 | -1 | 0.904 |
ABL2 |
0.647 | -0.019 | -1 | 0.827 |
HCK |
0.647 | 0.002 | -1 | 0.874 |
MAP2K4_TYR |
0.646 | -0.085 | -1 | 0.882 |
MAP2K6_TYR |
0.646 | -0.055 | -1 | 0.891 |
DDR2 |
0.646 | 0.074 | 3 | 0.253 |
EPHB4 |
0.646 | -0.009 | -1 | 0.867 |
KIT |
0.645 | 0.022 | 3 | 0.243 |
DDR1 |
0.645 | 0.011 | 4 | 0.835 |
FGFR3 |
0.645 | 0.105 | 3 | 0.268 |
LIMK1_TYR |
0.645 | -0.027 | 2 | 0.856 |
FLT3 |
0.644 | -0.042 | 3 | 0.203 |
ABL1 |
0.644 | -0.022 | -1 | 0.821 |
TNK1 |
0.644 | -0.012 | 3 | 0.193 |
PDHK1_TYR |
0.644 | -0.084 | -1 | 0.910 |
AXL |
0.643 | 0.061 | 3 | 0.290 |
PDGFRB |
0.642 | -0.032 | 3 | 0.229 |
MET |
0.642 | 0.034 | 3 | 0.257 |
TXK |
0.642 | -0.036 | 1 | 0.043 |
MERTK |
0.641 | 0.030 | 3 | 0.268 |
FLT4 |
0.641 | 0.032 | 3 | 0.255 |
TNNI3K_TYR |
0.640 | -0.025 | 1 | 0.107 |
EPHA1 |
0.640 | 0.053 | 3 | 0.287 |
YANK3 |
0.639 | -0.069 | 2 | 0.377 |
NEK10_TYR |
0.639 | -0.098 | 1 | 0.079 |
FYN |
0.639 | -0.003 | -1 | 0.872 |
EPHB1 |
0.638 | -0.049 | 1 | 0.041 |
PDGFRA |
0.638 | -0.043 | 3 | 0.224 |
STLK3 |
0.638 | -0.136 | 1 | 0.046 |
FRK |
0.638 | -0.019 | -1 | 0.874 |
INSR |
0.637 | -0.015 | 3 | 0.229 |
FGR |
0.637 | -0.118 | 1 | 0.050 |
ALK |
0.637 | -0.065 | 3 | 0.193 |
NTRK2 |
0.637 | 0.013 | 3 | 0.269 |
ITK |
0.635 | -0.099 | -1 | 0.832 |
EPHA7 |
0.635 | 0.008 | 2 | 0.749 |
SRMS |
0.635 | -0.054 | 1 | 0.036 |
LYN |
0.635 | -0.025 | 3 | 0.208 |
EPHB3 |
0.635 | -0.054 | -1 | 0.855 |
FER |
0.634 | -0.118 | 1 | 0.060 |
EPHB2 |
0.634 | -0.053 | -1 | 0.853 |
TEC |
0.634 | -0.038 | -1 | 0.761 |
EPHA4 |
0.633 | -0.035 | 2 | 0.744 |
ERBB2 |
0.633 | -0.044 | 1 | 0.062 |
FLT1 |
0.633 | -0.008 | -1 | 0.870 |
LTK |
0.633 | -0.067 | 3 | 0.202 |
SRC |
0.631 | -0.035 | -1 | 0.859 |
NTRK1 |
0.630 | -0.036 | -1 | 0.830 |
BMX |
0.630 | -0.064 | -1 | 0.748 |
CK1A |
0.629 | -0.065 | -3 | 0.377 |
PTK2B |
0.628 | -0.026 | -1 | 0.800 |
NTRK3 |
0.628 | -0.014 | -1 | 0.780 |
WEE1_TYR |
0.628 | -0.073 | -1 | 0.747 |
ERBB4 |
0.627 | 0.006 | 1 | 0.043 |
EPHA8 |
0.626 | -0.016 | -1 | 0.855 |
EPHA3 |
0.624 | -0.043 | 2 | 0.721 |
EGFR |
0.624 | -0.038 | 1 | 0.044 |
BTK |
0.624 | -0.150 | -1 | 0.786 |
EPHA5 |
0.623 | -0.022 | 2 | 0.728 |
FGFR4 |
0.623 | 0.000 | -1 | 0.790 |
MUSK |
0.623 | -0.072 | 1 | 0.030 |
IGF1R |
0.622 | -0.050 | 3 | 0.202 |
EPHA2 |
0.620 | -0.012 | -1 | 0.819 |
PTK2 |
0.619 | 0.008 | -1 | 0.864 |
MATK |
0.619 | -0.039 | -1 | 0.746 |
CSK |
0.616 | -0.097 | 2 | 0.755 |
CK1G3 |
0.612 | -0.069 | -3 | 0.328 |
PTK6 |
0.612 | -0.185 | -1 | 0.747 |
YANK2 |
0.610 | -0.074 | 2 | 0.390 |
FES |
0.610 | -0.055 | -1 | 0.726 |
SYK |
0.607 | -0.056 | -1 | 0.833 |
CK1G2 |
0.603 | -0.062 | -3 | 0.421 |
ZAP70 |
0.598 | -0.049 | -1 | 0.741 |