Motif 547 (n=161)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S686 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6NEL2 | SOWAHB | S509 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A8K0Z3 | WASHC1 | S219 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S232 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S217 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| M0QYT0 | None | S207 | ochoa | RRM domain-containing protein | None |
| O00567 | NOP56 | S530 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14974 | PPP1R12A | S862 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14986 | PIP5K1B | S448 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). {ECO:0000250|UniProtKB:P70181, ECO:0000250|UniProtKB:Q99755}. |
| O15085 | ARHGEF11 | S1458 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43597 | SPRY2 | S42 | psp | Protein sprouty homolog 2 (Spry-2) | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}. |
| O60361 | NME2P1 | S110 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60524 | NEMF | S833 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60673 | REV3L | S449 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75363 | BCAS1 | S381 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75363 | BCAS1 | S451 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75676 | RPS6KA4 | S634 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O75746 | SLC25A12 | S101 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:38945283}. |
| O75807 | PPP1R15A | S307 | ochoa | Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) | Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}. |
| O75962 | TRIO | S1724 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O76021 | RSL1D1 | S90 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O94953 | KDM4B | S632 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95235 | KIF20A | S47 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P01833 | PIGR | S702 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
| P02766 | TTR | S70 | ochoa | Transthyretin (ATTR) (Prealbumin) (TBPA) | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. {ECO:0000269|PubMed:3714052}. |
| P04350 | TUBB4A | S339 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P06213 | INSR | S1216 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P07437 | TUBB | S339 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08235 | NR3C2 | S936 | psp | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}. |
| P0DMV8 | HSPA1A | S106 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S106 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P15531 | NME1 | S125 | ochoa | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P16383 | GCFC2 | S96 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P18615 | NELFE | S140 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P19338 | NCL | S496 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20340 | RAB6A | S23 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P21127 | CDK11B | S434 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P21730 | C5AR1 | S327 | ochoa|psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P22059 | OSBP | S193 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22392 | NME2 | S125 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P25963 | NFKBIA | S288 | psp | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466). {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:36651806, ECO:0000269|PubMed:7479976, ECO:0000269|PubMed:7628694, ECO:0000269|PubMed:7796813, ECO:0000269|PubMed:7878466}. |
| P27540 | ARNT | S68 | ochoa | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| P29218 | IMPA1 | S166 | ochoa | Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) | Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol (PubMed:17068342, PubMed:8718889, PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (PubMed:17068342). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:17068342, PubMed:8718889, PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function (PubMed:26416544, PubMed:8718889). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder (PubMed:17068342). Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate (PubMed:9462881). {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:26416544, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}. |
| P31327 | CPS1 | S898 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31513 | FMO3 | S20 | ochoa | Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) | Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269). {ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:32156684, ECO:0000269|PubMed:9224773, ECO:0000269|PubMed:9776311}. |
| P31942 | HNRNPH3 | S56 | ochoa | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. |
| P34910 | EVI2B | S295 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35221 | CTNNA1 | S690 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35659 | DEK | S230 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P38398 | BRCA1 | S1572 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P47900 | P2RY1 | S352 | ochoa|psp | P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) | Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}. |
| P49326 | FMO5 | S54 | ochoa | Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) | Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:20947616, PubMed:26771671, PubMed:28783300). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}. |
| P49327 | FASN | S1481 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P52948 | NUP98 | S709 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54132 | BLM | S72 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54819 | AK2 | S151 | ochoa | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| P55201 | BRPF1 | S120 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P57740 | NUP107 | S129 | ochoa|psp | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
| P61006 | RAB8A | S111 | ochoa|psp | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}. |
| P68371 | TUBB4B | S339 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q03188 | CENPC | S679 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q07866 | KLC1 | S162 | ochoa | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q09028 | RBBP4 | S112 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q0JRZ9 | FCHO2 | S324 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12774 | ARHGEF5 | S474 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13011 | ECH1 | S37 | ochoa | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| Q13029 | PRDM2 | S1256 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13113 | PDZK1IP1 | S93 | ochoa | PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96) | Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1 (PubMed:34880493, PubMed:37217492, PubMed:38057552). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (PubMed:37217492). {ECO:0000269|PubMed:34880493, ECO:0000269|PubMed:37217492, ECO:0000269|PubMed:38057552}. |
| Q13362 | PPP2R5C | S298 | psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
| Q13415 | ORC1 | S403 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13422 | IKZF1 | S296 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13509 | TUBB3 | S339 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13615 | MTMR3 | S701 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13885 | TUBB2A | S339 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14151 | SAFB2 | S54 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14517 | FAT1 | S4276 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14692 | BMS1 | S625 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q15022 | SUZ12 | S546 | ochoa|psp | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15390 | MTFR1 | S115 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q15424 | SAFB | S55 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15554 | TERF2 | S412 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q15772 | SPEG | S2566 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16363 | LAMA4 | S954 | ochoa | Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Q4VC05 | BCL7A | S186 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q5TDH0 | DDI2 | S150 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q6IQ55 | TTBK2 | S479 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NYC1 | JMJD6 | S136 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6P6C2 | ALKBH5 | S69 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6UWE0 | LRSAM1 | S290 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q6VEQ5 | WASH2P | S219 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6W2J9 | BCOR | S1269 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZS30 | NBEAL1 | S1841 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q7L590 | MCM10 | S514 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7LG56 | RRM2B | S20 | ochoa | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}. |
| Q7RTP6 | MICAL3 | S1346 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2K8 | GPRIN1 | S118 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | S2952 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UR5 | RIMS1 | S977 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86VF7 | NRAP | S1482 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q86VP6 | CAND1 | S859 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86X29 | LSR | S581 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XZ4 | SPATS2 | S114 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IVF2 | AHNAK2 | S5175 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S5657 | ochoa | Protein AHNAK2 | None |
| Q8IWB6 | TEX14 | S437 | psp | Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) | Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}. |
| Q8IZC4 | RTKN2 | S571 | ochoa | Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) | May play an important role in lymphopoiesis. {ECO:0000269|PubMed:15504364}. |
| Q8IZT6 | ASPM | S267 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N165 | PDIK1L | S194 | ochoa|psp | Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) | None |
| Q8TDR2 | STK35 | S385 | ochoa|psp | Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) | None |
| Q8TEW0 | PARD3 | S971 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WVC0 | LEO1 | S229 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WX93 | PALLD | S984 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WY36 | BBX | S178 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q96C24 | SYTL4 | S274 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96CC6 | RHBDF1 | S245 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96ER3 | SAAL1 | S56 | ochoa | Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1) | Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli. {ECO:0000269|PubMed:22127701}. |
| Q96FQ6 | S100A16 | S36 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96GA3 | LTV1 | S331 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96ME7 | ZNF512 | S319 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q9BTC0 | DIDO1 | S206 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUF5 | TUBB6 | S339 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S339 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXF6 | RAB11FIP5 | S499 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXL6 | CARD14 | S259 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BZF1 | OSBPL8 | S305 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0B9 | ZCCHC2 | S493 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9C0D5 | TANC1 | S1711 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H2S1 | KCNN2 | S464 | psp | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:10991935). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (PubMed:13679367). {ECO:0000250|UniProtKB:P70604, ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:33242881, ECO:0000269|PubMed:9287325}. |
| Q9H501 | ESF1 | S228 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H582 | ZNF644 | S1140 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6A9 | PCNX3 | S178 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H788 | SH2D4A | S317 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9HAU0 | PLEKHA5 | S822 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NQ84 | GPRC5C | S335 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQA3 | WASH6P | S201 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NQC7 | CYLD | S362 | psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NRW1 | RAB6B | S23 | ochoa | Ras-related protein Rab-6B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}. |
| Q9NS91 | RAD18 | S322 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NVW2 | RLIM | S248 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NWM3 | CUEDC1 | S122 | ochoa | CUE domain-containing protein 1 | None |
| Q9NXX6 | NSMCE4A | S63 | ochoa | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
| Q9NZ01 | TECR | S58 | ochoa | Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) | Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234). {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:25049234}. |
| Q9P266 | JCAD | S1326 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D6 | FAM135A | S707 | ochoa | Protein FAM135A | None |
| Q9UJV9 | DDX41 | Y414 | psp | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKK3 | PARP4 | S1491 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULH0 | KIDINS220 | S1526 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9UQ88 | CDK11A | S422 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y282 | ERGIC3 | S116 | ochoa | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) | Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}. |
| Q9Y446 | PKP3 | S698 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y5B9 | SUPT16H | S188 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y6Q9 | NCOA3 | S601 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| O15530 | PDPK1 | S176 | Sugiyama | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| Q6A1A2 | PDPK2P | S149 | Sugiyama | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| P62241 | RPS8 | S66 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P08174 | CD55 | Y63 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q96CN4 | EVI5L | S494 | Sugiyama | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| P42680 | TEC | S523 | Sugiyama | Tyrosine-protein kinase Tec (EC 2.7.10.2) | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}. |
| Q7Z4S6 | KIF21A | S708 | Sugiyama | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q8IU85 | CAMK1D | S154 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Q96RR4 | CAMKK2 | S503 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.108114e-12 | 11.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.270983e-12 | 11.896 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.495148e-11 | 10.825 |
| R-HSA-3371556 | Cellular response to heat stress | 1.735656e-11 | 10.761 |
| R-HSA-3371511 | HSF1 activation | 2.143364e-10 | 9.669 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.297835e-08 | 7.887 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.402538e-08 | 7.853 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.894968e-08 | 7.722 |
| R-HSA-983189 | Kinesins | 1.613292e-08 | 7.792 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.512031e-08 | 7.346 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.086475e-07 | 6.964 |
| R-HSA-2262752 | Cellular responses to stress | 1.404219e-07 | 6.853 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.327532e-07 | 6.633 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.584055e-07 | 6.588 |
| R-HSA-1640170 | Cell Cycle | 3.084987e-07 | 6.511 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.728442e-07 | 6.428 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.633866e-07 | 6.440 |
| R-HSA-437239 | Recycling pathway of L1 | 4.897554e-07 | 6.310 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 6.484068e-07 | 6.188 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 7.929857e-07 | 6.101 |
| R-HSA-190861 | Gap junction assembly | 9.015773e-07 | 6.045 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.807789e-07 | 6.008 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.981442e-07 | 6.001 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.073322e-06 | 5.969 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.695547e-06 | 5.771 |
| R-HSA-9833482 | PKR-mediated signaling | 1.695547e-06 | 5.771 |
| R-HSA-69275 | G2/M Transition | 1.786982e-06 | 5.748 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.855759e-06 | 5.731 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.985082e-06 | 5.702 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.251594e-06 | 5.648 |
| R-HSA-9646399 | Aggrephagy | 2.205850e-06 | 5.656 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.893297e-06 | 5.539 |
| R-HSA-9609690 | HCMV Early Events | 2.987051e-06 | 5.525 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.414208e-06 | 5.467 |
| R-HSA-190828 | Gap junction trafficking | 4.253457e-06 | 5.371 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.108870e-06 | 5.214 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.926700e-06 | 5.159 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.385778e-06 | 5.132 |
| R-HSA-157858 | Gap junction trafficking and regulation | 7.685717e-06 | 5.114 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.287751e-06 | 5.082 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.241292e-05 | 4.906 |
| R-HSA-68877 | Mitotic Prometaphase | 1.383173e-05 | 4.859 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.753061e-05 | 4.756 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.897699e-05 | 4.722 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.972820e-05 | 4.527 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.835975e-05 | 4.547 |
| R-HSA-9609646 | HCMV Infection | 3.233313e-05 | 4.490 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.880270e-05 | 4.231 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.477253e-05 | 4.261 |
| R-HSA-5620924 | Intraflagellar transport | 7.336875e-05 | 4.134 |
| R-HSA-68886 | M Phase | 1.436130e-04 | 3.843 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.546017e-04 | 3.811 |
| R-HSA-68882 | Mitotic Anaphase | 1.736396e-04 | 3.760 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.800157e-04 | 3.745 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.986690e-04 | 3.702 |
| R-HSA-9663891 | Selective autophagy | 2.114595e-04 | 3.675 |
| R-HSA-373760 | L1CAM interactions | 2.204539e-04 | 3.657 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.771066e-04 | 3.557 |
| R-HSA-5617833 | Cilium Assembly | 2.785567e-04 | 3.555 |
| R-HSA-391251 | Protein folding | 2.857616e-04 | 3.544 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.713557e-04 | 3.243 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.132295e-04 | 3.147 |
| R-HSA-1632852 | Macroautophagy | 7.880159e-04 | 3.103 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.037747e-03 | 2.984 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.058880e-03 | 2.975 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.170459e-03 | 2.932 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.170459e-03 | 2.932 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.417872e-03 | 2.848 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.417872e-03 | 2.848 |
| R-HSA-9612973 | Autophagy | 1.447845e-03 | 2.839 |
| R-HSA-913531 | Interferon Signaling | 1.490724e-03 | 2.827 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.554302e-03 | 2.808 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.554302e-03 | 2.808 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.854093e-03 | 2.732 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.699611e-03 | 2.770 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.191746e-03 | 2.659 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.353992e-03 | 2.628 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.375497e-03 | 2.624 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.569582e-03 | 2.590 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.774283e-03 | 2.557 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.774283e-03 | 2.557 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.774283e-03 | 2.557 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.569582e-03 | 2.590 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.572291e-03 | 2.590 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.989882e-03 | 2.524 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 3.167078e-03 | 2.499 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.337565e-03 | 2.477 |
| R-HSA-380287 | Centrosome maturation | 3.698199e-03 | 2.432 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.240979e-03 | 2.373 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.290362e-03 | 2.368 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.395971e-03 | 2.357 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 5.573473e-03 | 2.254 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.672548e-03 | 2.246 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.080142e-03 | 2.216 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.548385e-03 | 2.184 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.650957e-03 | 2.116 |
| R-HSA-193648 | NRAGE signals death through JNK | 8.137844e-03 | 2.089 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.167082e-03 | 2.088 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 8.578292e-03 | 2.067 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.332865e-03 | 2.030 |
| R-HSA-194441 | Metabolism of non-coding RNA | 9.505337e-03 | 2.022 |
| R-HSA-191859 | snRNP Assembly | 9.505337e-03 | 2.022 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.880521e-03 | 2.005 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.049524e-02 | 1.979 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.101424e-02 | 1.958 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.101424e-02 | 1.958 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.165704e-02 | 1.933 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.235904e-02 | 1.908 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.291814e-02 | 1.889 |
| R-HSA-217271 | FMO oxidises nucleophiles | 1.471253e-02 | 1.832 |
| R-HSA-6798695 | Neutrophil degranulation | 1.482603e-02 | 1.829 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.423739e-02 | 1.847 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.606248e-02 | 1.794 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.665462e-02 | 1.778 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.712700e-02 | 1.766 |
| R-HSA-199991 | Membrane Trafficking | 1.754033e-02 | 1.756 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.783392e-02 | 1.749 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.783392e-02 | 1.749 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.860095e-02 | 1.730 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.930169e-02 | 1.714 |
| R-HSA-73887 | Death Receptor Signaling | 1.953928e-02 | 1.709 |
| R-HSA-162587 | HIV Life Cycle | 2.104976e-02 | 1.677 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.144625e-02 | 1.669 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.163985e-02 | 1.665 |
| R-HSA-9824446 | Viral Infection Pathways | 2.365165e-02 | 1.626 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.405086e-02 | 1.619 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.405086e-02 | 1.619 |
| R-HSA-8854214 | TBC/RABGAPs | 2.498850e-02 | 1.602 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.501643e-02 | 1.602 |
| R-HSA-1500620 | Meiosis | 2.774611e-02 | 1.557 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.869394e-02 | 1.542 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.869394e-02 | 1.542 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.508582e-02 | 1.455 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.777329e-02 | 1.423 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.777329e-02 | 1.423 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.777329e-02 | 1.423 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.777329e-02 | 1.423 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.762647e-02 | 1.425 |
| R-HSA-168255 | Influenza Infection | 3.530470e-02 | 1.452 |
| R-HSA-112316 | Neuronal System | 3.819611e-02 | 1.418 |
| R-HSA-1221632 | Meiotic synapsis | 3.919808e-02 | 1.407 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.919808e-02 | 1.407 |
| R-HSA-74160 | Gene expression (Transcription) | 4.044986e-02 | 1.393 |
| R-HSA-9755088 | Ribavirin ADME | 4.337445e-02 | 1.363 |
| R-HSA-422475 | Axon guidance | 4.541470e-02 | 1.343 |
| R-HSA-9918449 | Defective visual phototransduction due to STRA6 loss of function | 4.752615e-02 | 1.323 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.775264e-02 | 1.321 |
| R-HSA-70171 | Glycolysis | 4.775264e-02 | 1.321 |
| R-HSA-1483255 | PI Metabolism | 5.036221e-02 | 1.298 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.111172e-02 | 1.291 |
| R-HSA-597592 | Post-translational protein modification | 5.440429e-02 | 1.264 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 5.542112e-02 | 1.256 |
| R-HSA-3214842 | HDMs demethylate histones | 5.542112e-02 | 1.256 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.669473e-02 | 1.246 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.669473e-02 | 1.246 |
| R-HSA-5579019 | Defective FMO3 causes TMAU | 7.043959e-02 | 1.152 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 6.183348e-02 | 1.209 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 6.183348e-02 | 1.209 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 6.183348e-02 | 1.209 |
| R-HSA-167287 | HIV elongation arrest and recovery | 6.512998e-02 | 1.186 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 6.512998e-02 | 1.186 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.848414e-02 | 1.164 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.255463e-02 | 1.204 |
| R-HSA-68962 | Activation of the pre-replicative complex | 7.189410e-02 | 1.143 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 5.859655e-02 | 1.232 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 5.859655e-02 | 1.232 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.167152e-02 | 1.210 |
| R-HSA-70635 | Urea cycle | 5.859655e-02 | 1.232 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.859655e-02 | 1.232 |
| R-HSA-212436 | Generic Transcription Pathway | 6.772859e-02 | 1.169 |
| R-HSA-70326 | Glucose metabolism | 7.726639e-02 | 1.112 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.183348e-02 | 1.209 |
| R-HSA-109582 | Hemostasis | 6.824085e-02 | 1.166 |
| R-HSA-9675108 | Nervous system development | 6.643138e-02 | 1.178 |
| R-HSA-211000 | Gene Silencing by RNA | 5.865175e-02 | 1.232 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.947711e-02 | 1.100 |
| R-HSA-74713 | IRS activation | 8.168980e-02 | 1.088 |
| R-HSA-165158 | Activation of AKT2 | 8.168980e-02 | 1.088 |
| R-HSA-68875 | Mitotic Prophase | 8.233257e-02 | 1.084 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 8.244075e-02 | 1.084 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.244075e-02 | 1.084 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 8.244075e-02 | 1.084 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 8.244075e-02 | 1.084 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.262672e-02 | 1.083 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.268386e-02 | 1.083 |
| R-HSA-162906 | HIV Infection | 8.300144e-02 | 1.081 |
| R-HSA-73886 | Chromosome Maintenance | 8.405700e-02 | 1.075 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.422927e-02 | 1.075 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 8.605603e-02 | 1.065 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.933589e-02 | 1.049 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.971834e-02 | 1.047 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.971834e-02 | 1.047 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 9.280454e-02 | 1.032 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.280454e-02 | 1.032 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 9.280454e-02 | 1.032 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 9.280454e-02 | 1.032 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 9.280454e-02 | 1.032 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 9.280454e-02 | 1.032 |
| R-HSA-69206 | G1/S Transition | 9.294207e-02 | 1.032 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 9.342603e-02 | 1.030 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.037854e-01 | 0.984 |
| R-HSA-170984 | ARMS-mediated activation | 1.359410e-01 | 0.867 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.359410e-01 | 0.867 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 9.717748e-02 | 1.012 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.125895e-01 | 0.949 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.367644e-01 | 0.864 |
| R-HSA-774815 | Nucleosome assembly | 1.367644e-01 | 0.864 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.125895e-01 | 0.949 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.205183e-01 | 0.919 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.086786e-01 | 0.964 |
| R-HSA-167169 | HIV Transcription Elongation | 1.125895e-01 | 0.949 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.359410e-01 | 0.867 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.359410e-01 | 0.867 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.101477e-01 | 0.958 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.048053e-01 | 0.980 |
| R-HSA-8964046 | VLDL clearance | 1.146341e-01 | 0.941 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 1.146341e-01 | 0.941 |
| R-HSA-9710421 | Defective pyroptosis | 1.285802e-01 | 0.891 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.253521e-01 | 0.902 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.165366e-01 | 0.934 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.165366e-01 | 0.934 |
| R-HSA-444257 | RSK activation | 1.253521e-01 | 0.902 |
| R-HSA-69481 | G2/M Checkpoints | 9.661669e-02 | 1.015 |
| R-HSA-9675135 | Diseases of DNA repair | 1.408990e-01 | 0.851 |
| R-HSA-1474165 | Reproduction | 1.041673e-01 | 0.982 |
| R-HSA-4839726 | Chromatin organization | 1.123059e-01 | 0.950 |
| R-HSA-1280218 | Adaptive Immune System | 1.012922e-01 | 0.994 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.106517e-01 | 0.956 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 9.717748e-02 | 1.012 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.081057e-01 | 0.966 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.086786e-01 | 0.964 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.934843e-02 | 1.003 |
| R-HSA-162582 | Signal Transduction | 1.232009e-01 | 0.909 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.165366e-01 | 0.934 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.325967e-01 | 0.877 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.412532e-01 | 0.850 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.567376e-01 | 0.805 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.567376e-01 | 0.805 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.567376e-01 | 0.805 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.669485e-01 | 0.777 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.770363e-01 | 0.752 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.770363e-01 | 0.752 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.770363e-01 | 0.752 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.770363e-01 | 0.752 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.770363e-01 | 0.752 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.065762e-01 | 0.685 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.065762e-01 | 0.685 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.065762e-01 | 0.685 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.161865e-01 | 0.665 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.256810e-01 | 0.647 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.350611e-01 | 0.629 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.534834e-01 | 0.596 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.625283e-01 | 0.581 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.625283e-01 | 0.581 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.010547e-01 | 0.697 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.669485e-01 | 0.777 |
| R-HSA-180786 | Extension of Telomeres | 1.966505e-01 | 0.706 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.625283e-01 | 0.581 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.065762e-01 | 0.685 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.500678e-01 | 0.602 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.338518e-01 | 0.631 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.714642e-01 | 0.566 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.065762e-01 | 0.685 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.321561e-01 | 0.634 |
| R-HSA-4839744 | Signaling by APC mutants | 1.567376e-01 | 0.805 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.669485e-01 | 0.777 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.669485e-01 | 0.777 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.669485e-01 | 0.777 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.870025e-01 | 0.728 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.443281e-01 | 0.612 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.625283e-01 | 0.581 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.597099e-01 | 0.586 |
| R-HSA-167172 | Transcription of the HIV genome | 2.366277e-01 | 0.626 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.966505e-01 | 0.706 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.595435e-01 | 0.797 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.688693e-01 | 0.772 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.688693e-01 | 0.772 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.065762e-01 | 0.685 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.464023e-01 | 0.834 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.065762e-01 | 0.685 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.443281e-01 | 0.612 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.890141e-01 | 0.539 |
| R-HSA-912446 | Meiotic recombination | 1.619481e-01 | 0.791 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.321561e-01 | 0.634 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.662247e-01 | 0.779 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.187774e-01 | 0.660 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.669485e-01 | 0.777 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.714642e-01 | 0.566 |
| R-HSA-73893 | DNA Damage Bypass | 1.534582e-01 | 0.814 |
| R-HSA-72312 | rRNA processing | 1.948899e-01 | 0.710 |
| R-HSA-169893 | Prolonged ERK activation events | 2.161865e-01 | 0.665 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.625283e-01 | 0.581 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.492472e-01 | 0.826 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.669485e-01 | 0.777 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.065762e-01 | 0.685 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.534834e-01 | 0.596 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.143326e-01 | 0.669 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.635303e-01 | 0.579 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.464023e-01 | 0.834 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.968487e-01 | 0.706 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.065762e-01 | 0.685 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.065762e-01 | 0.685 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.450604e-01 | 0.838 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.010547e-01 | 0.697 |
| R-HSA-73894 | DNA Repair | 1.831152e-01 | 0.737 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.859231e-01 | 0.544 |
| R-HSA-8852135 | Protein ubiquitination | 2.680195e-01 | 0.572 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.680195e-01 | 0.572 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.968487e-01 | 0.706 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.276899e-01 | 0.643 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.455843e-01 | 0.610 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.534834e-01 | 0.596 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.065762e-01 | 0.685 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.877710e-01 | 0.726 |
| R-HSA-74749 | Signal attenuation | 1.464023e-01 | 0.834 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.968487e-01 | 0.706 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.065762e-01 | 0.685 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.350611e-01 | 0.629 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.548536e-01 | 0.810 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.161865e-01 | 0.665 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.534834e-01 | 0.596 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.990982e-01 | 0.701 |
| R-HSA-392499 | Metabolism of proteins | 2.747663e-01 | 0.561 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.147873e-01 | 0.668 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.870025e-01 | 0.728 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.256810e-01 | 0.647 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.443281e-01 | 0.612 |
| R-HSA-9748787 | Azathioprine ADME | 1.576922e-01 | 0.802 |
| R-HSA-9610379 | HCMV Late Events | 1.661564e-01 | 0.779 |
| R-HSA-9629569 | Protein hydroxylation | 2.625283e-01 | 0.581 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.600602e-01 | 0.796 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.455843e-01 | 0.610 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.443281e-01 | 0.612 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.770363e-01 | 0.752 |
| R-HSA-417957 | P2Y receptors | 1.968487e-01 | 0.706 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.534834e-01 | 0.596 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.890141e-01 | 0.539 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.010547e-01 | 0.697 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 2.443281e-01 | 0.612 |
| R-HSA-73942 | DNA Damage Reversal | 2.065762e-01 | 0.685 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.748192e-01 | 0.757 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.366277e-01 | 0.626 |
| R-HSA-2559583 | Cellular Senescence | 2.251604e-01 | 0.648 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.455843e-01 | 0.610 |
| R-HSA-8964038 | LDL clearance | 2.890141e-01 | 0.539 |
| R-HSA-15869 | Metabolism of nucleotides | 2.033377e-01 | 0.692 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.143326e-01 | 0.669 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.746809e-01 | 0.758 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.859671e-01 | 0.544 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.769964e-01 | 0.558 |
| R-HSA-9679506 | SARS-CoV Infections | 1.668908e-01 | 0.778 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.655918e-01 | 0.781 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.124217e-01 | 0.673 |
| R-HSA-72306 | tRNA processing | 1.998976e-01 | 0.699 |
| R-HSA-5619102 | SLC transporter disorders | 1.900474e-01 | 0.721 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.949267e-01 | 0.530 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.976307e-01 | 0.526 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.976307e-01 | 0.526 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 3.061434e-01 | 0.514 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.061434e-01 | 0.514 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.061434e-01 | 0.514 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.061434e-01 | 0.514 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.127944e-01 | 0.505 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.145534e-01 | 0.502 |
| R-HSA-3000157 | Laminin interactions | 3.145534e-01 | 0.502 |
| R-HSA-420029 | Tight junction interactions | 3.145534e-01 | 0.502 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.145534e-01 | 0.502 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.145534e-01 | 0.502 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.145534e-01 | 0.502 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.145534e-01 | 0.502 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.145534e-01 | 0.502 |
| R-HSA-2453864 | Retinoid cycle disease events | 3.145534e-01 | 0.502 |
| R-HSA-9675143 | Diseases of the neuronal system | 3.145534e-01 | 0.502 |
| R-HSA-2474795 | Diseases associated with visual transduction | 3.145534e-01 | 0.502 |
| R-HSA-525793 | Myogenesis | 3.228620e-01 | 0.491 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.228620e-01 | 0.491 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.228620e-01 | 0.491 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.228620e-01 | 0.491 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.228620e-01 | 0.491 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.242002e-01 | 0.489 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.305651e-01 | 0.481 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.310704e-01 | 0.480 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.310704e-01 | 0.480 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.310704e-01 | 0.480 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.310704e-01 | 0.480 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.355188e-01 | 0.474 |
| R-HSA-1483257 | Phospholipid metabolism | 3.384562e-01 | 0.470 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.391798e-01 | 0.470 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.391798e-01 | 0.470 |
| R-HSA-77387 | Insulin receptor recycling | 3.391798e-01 | 0.470 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.391798e-01 | 0.470 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.391798e-01 | 0.470 |
| R-HSA-202424 | Downstream TCR signaling | 3.394042e-01 | 0.469 |
| R-HSA-5663205 | Infectious disease | 3.405796e-01 | 0.468 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.438106e-01 | 0.464 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.454463e-01 | 0.462 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.471913e-01 | 0.459 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.471913e-01 | 0.459 |
| R-HSA-8953854 | Metabolism of RNA | 3.498080e-01 | 0.456 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.525950e-01 | 0.453 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.551063e-01 | 0.450 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.551063e-01 | 0.450 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.561688e-01 | 0.448 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.629257e-01 | 0.440 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.629257e-01 | 0.440 |
| R-HSA-182971 | EGFR downregulation | 3.629257e-01 | 0.440 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 3.629257e-01 | 0.440 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.629257e-01 | 0.440 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.656944e-01 | 0.437 |
| R-HSA-1538133 | G0 and Early G1 | 3.706509e-01 | 0.431 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.706509e-01 | 0.431 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.706509e-01 | 0.431 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.743713e-01 | 0.427 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.782828e-01 | 0.422 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.782828e-01 | 0.422 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.782828e-01 | 0.422 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.782828e-01 | 0.422 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.782828e-01 | 0.422 |
| R-HSA-354192 | Integrin signaling | 3.782828e-01 | 0.422 |
| R-HSA-157579 | Telomere Maintenance | 3.786919e-01 | 0.422 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.786919e-01 | 0.422 |
| R-HSA-8939211 | ESR-mediated signaling | 3.816717e-01 | 0.418 |
| R-HSA-390522 | Striated Muscle Contraction | 3.858226e-01 | 0.414 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.858226e-01 | 0.414 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.858226e-01 | 0.414 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.932715e-01 | 0.405 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.932715e-01 | 0.405 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.932715e-01 | 0.405 |
| R-HSA-392518 | Signal amplification | 3.932715e-01 | 0.405 |
| R-HSA-5673000 | RAF activation | 3.932715e-01 | 0.405 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.932715e-01 | 0.405 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.932715e-01 | 0.405 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.001027e-01 | 0.398 |
| R-HSA-187687 | Signalling to ERKs | 4.006304e-01 | 0.397 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.006304e-01 | 0.397 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.056463e-01 | 0.392 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.079006e-01 | 0.389 |
| R-HSA-111933 | Calmodulin induced events | 4.079006e-01 | 0.389 |
| R-HSA-111997 | CaM pathway | 4.079006e-01 | 0.389 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.079006e-01 | 0.389 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.085715e-01 | 0.389 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.090149e-01 | 0.388 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.142688e-01 | 0.383 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.142688e-01 | 0.383 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.150830e-01 | 0.382 |
| R-HSA-421270 | Cell-cell junction organization | 4.198910e-01 | 0.377 |
| R-HSA-73927 | Depurination | 4.221788e-01 | 0.375 |
| R-HSA-9931953 | Biofilm formation | 4.221788e-01 | 0.375 |
| R-HSA-8875878 | MET promotes cell motility | 4.221788e-01 | 0.375 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.291889e-01 | 0.367 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.334209e-01 | 0.363 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.336214e-01 | 0.363 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.361143e-01 | 0.360 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.361143e-01 | 0.360 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.361143e-01 | 0.360 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.361143e-01 | 0.360 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.361143e-01 | 0.360 |
| R-HSA-5260271 | Diseases of Immune System | 4.361143e-01 | 0.360 |
| R-HSA-202403 | TCR signaling | 4.377418e-01 | 0.359 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.429562e-01 | 0.354 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.462905e-01 | 0.350 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.497155e-01 | 0.347 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.497155e-01 | 0.347 |
| R-HSA-168256 | Immune System | 4.540074e-01 | 0.343 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.540591e-01 | 0.343 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.540591e-01 | 0.343 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.563932e-01 | 0.341 |
| R-HSA-111996 | Ca-dependent events | 4.563932e-01 | 0.341 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.563932e-01 | 0.341 |
| R-HSA-73928 | Depyrimidination | 4.563932e-01 | 0.341 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.563932e-01 | 0.341 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.621164e-01 | 0.335 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.629902e-01 | 0.334 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 4.629902e-01 | 0.334 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.629902e-01 | 0.334 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.629902e-01 | 0.334 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.661191e-01 | 0.332 |
| R-HSA-373752 | Netrin-1 signaling | 4.695076e-01 | 0.328 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.695076e-01 | 0.328 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.695076e-01 | 0.328 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.759463e-01 | 0.322 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.759463e-01 | 0.322 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.759463e-01 | 0.322 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 4.759463e-01 | 0.322 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 4.759463e-01 | 0.322 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.759463e-01 | 0.322 |
| R-HSA-5693538 | Homology Directed Repair | 4.780213e-01 | 0.321 |
| R-HSA-168249 | Innate Immune System | 4.786338e-01 | 0.320 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.813357e-01 | 0.318 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.823072e-01 | 0.317 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.823072e-01 | 0.317 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.868423e-01 | 0.313 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.885914e-01 | 0.311 |
| R-HSA-446728 | Cell junction organization | 4.917778e-01 | 0.308 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.947996e-01 | 0.306 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.974962e-01 | 0.303 |
| R-HSA-9766229 | Degradation of CDH1 | 5.009328e-01 | 0.300 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.021334e-01 | 0.299 |
| R-HSA-977606 | Regulation of Complement cascade | 5.051564e-01 | 0.297 |
| R-HSA-109704 | PI3K Cascade | 5.069920e-01 | 0.295 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.080843e-01 | 0.294 |
| R-HSA-194138 | Signaling by VEGF | 5.089582e-01 | 0.293 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.129779e-01 | 0.290 |
| R-HSA-114608 | Platelet degranulation | 5.165046e-01 | 0.287 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.188916e-01 | 0.285 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.188916e-01 | 0.285 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.188916e-01 | 0.285 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.247338e-01 | 0.280 |
| R-HSA-1266738 | Developmental Biology | 5.285006e-01 | 0.277 |
| R-HSA-72649 | Translation initiation complex formation | 5.305054e-01 | 0.275 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.305054e-01 | 0.275 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.305054e-01 | 0.275 |
| R-HSA-9843745 | Adipogenesis | 5.350335e-01 | 0.272 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.362073e-01 | 0.271 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.362073e-01 | 0.271 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.405195e-01 | 0.267 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.418403e-01 | 0.266 |
| R-HSA-75893 | TNF signaling | 5.418403e-01 | 0.266 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.418403e-01 | 0.266 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.418403e-01 | 0.266 |
| R-HSA-177929 | Signaling by EGFR | 5.418403e-01 | 0.266 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.423085e-01 | 0.266 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.474052e-01 | 0.262 |
| R-HSA-112399 | IRS-mediated signalling | 5.474052e-01 | 0.262 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.529028e-01 | 0.257 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.529028e-01 | 0.257 |
| R-HSA-418990 | Adherens junctions interactions | 5.548550e-01 | 0.256 |
| R-HSA-163685 | Integration of energy metabolism | 5.566214e-01 | 0.254 |
| R-HSA-9033241 | Peroxisomal protein import | 5.583341e-01 | 0.253 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.636586e-01 | 0.249 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.636996e-01 | 0.249 |
| R-HSA-6807070 | PTEN Regulation | 5.671473e-01 | 0.246 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.690003e-01 | 0.245 |
| R-HSA-112043 | PLC beta mediated events | 5.690003e-01 | 0.245 |
| R-HSA-211976 | Endogenous sterols | 5.690003e-01 | 0.245 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.742370e-01 | 0.241 |
| R-HSA-1268020 | Mitochondrial protein import | 5.742370e-01 | 0.241 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.742370e-01 | 0.241 |
| R-HSA-373755 | Semaphorin interactions | 5.794103e-01 | 0.237 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.845211e-01 | 0.233 |
| R-HSA-211981 | Xenobiotics | 5.845211e-01 | 0.233 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.845211e-01 | 0.233 |
| R-HSA-1500931 | Cell-Cell communication | 5.860449e-01 | 0.232 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.876578e-01 | 0.231 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.895701e-01 | 0.229 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.895701e-01 | 0.229 |
| R-HSA-166658 | Complement cascade | 5.910058e-01 | 0.228 |
| R-HSA-112040 | G-protein mediated events | 5.994857e-01 | 0.222 |
| R-HSA-196807 | Nicotinate metabolism | 5.994857e-01 | 0.222 |
| R-HSA-69242 | S Phase | 6.009290e-01 | 0.221 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.074437e-01 | 0.216 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 6.091630e-01 | 0.215 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.139140e-01 | 0.212 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.139140e-01 | 0.212 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.139140e-01 | 0.212 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.139140e-01 | 0.212 |
| R-HSA-69306 | DNA Replication | 6.170647e-01 | 0.210 |
| R-HSA-9609507 | Protein localization | 6.170647e-01 | 0.210 |
| R-HSA-3000178 | ECM proteoglycans | 6.186075e-01 | 0.209 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.186075e-01 | 0.209 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.232443e-01 | 0.205 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.232443e-01 | 0.205 |
| R-HSA-1989781 | PPARA activates gene expression | 6.233782e-01 | 0.205 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.278250e-01 | 0.202 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.296114e-01 | 0.201 |
| R-HSA-917937 | Iron uptake and transport | 6.368209e-01 | 0.196 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.388111e-01 | 0.195 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.412373e-01 | 0.193 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.456003e-01 | 0.190 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.499106e-01 | 0.187 |
| R-HSA-5688426 | Deubiquitination | 6.522520e-01 | 0.186 |
| R-HSA-9659379 | Sensory processing of sound | 6.541686e-01 | 0.184 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 6.541686e-01 | 0.184 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.553456e-01 | 0.184 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.583752e-01 | 0.182 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.583752e-01 | 0.182 |
| R-HSA-6806834 | Signaling by MET | 6.583752e-01 | 0.182 |
| R-HSA-977225 | Amyloid fiber formation | 6.625308e-01 | 0.179 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.625308e-01 | 0.179 |
| R-HSA-416476 | G alpha (q) signalling events | 6.735200e-01 | 0.172 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.738265e-01 | 0.171 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.766172e-01 | 0.170 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.793885e-01 | 0.168 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.864293e-01 | 0.163 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.864293e-01 | 0.163 |
| R-HSA-156902 | Peptide chain elongation | 6.940152e-01 | 0.159 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.014185e-01 | 0.154 |
| R-HSA-73884 | Base Excision Repair | 7.014185e-01 | 0.154 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.014185e-01 | 0.154 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.046883e-01 | 0.152 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.050530e-01 | 0.152 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.086435e-01 | 0.150 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.121905e-01 | 0.147 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.121905e-01 | 0.147 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.121905e-01 | 0.147 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.121905e-01 | 0.147 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.156945e-01 | 0.145 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.191562e-01 | 0.143 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.225758e-01 | 0.141 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.259541e-01 | 0.139 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.259541e-01 | 0.139 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.259541e-01 | 0.139 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.267098e-01 | 0.139 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.292914e-01 | 0.137 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 7.292914e-01 | 0.137 |
| R-HSA-1296071 | Potassium Channels | 7.292914e-01 | 0.137 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.332297e-01 | 0.135 |
| R-HSA-190236 | Signaling by FGFR | 7.358452e-01 | 0.133 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.358452e-01 | 0.133 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.358452e-01 | 0.133 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.358452e-01 | 0.133 |
| R-HSA-3214847 | HATs acetylate histones | 7.390626e-01 | 0.131 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.390626e-01 | 0.131 |
| R-HSA-195721 | Signaling by WNT | 7.452233e-01 | 0.128 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.453810e-01 | 0.128 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.453810e-01 | 0.128 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.453810e-01 | 0.128 |
| R-HSA-372790 | Signaling by GPCR | 7.462707e-01 | 0.127 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.471393e-01 | 0.127 |
| R-HSA-192823 | Viral mRNA Translation | 7.515472e-01 | 0.124 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.545744e-01 | 0.122 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.545744e-01 | 0.122 |
| R-HSA-111885 | Opioid Signalling | 7.545744e-01 | 0.122 |
| R-HSA-388396 | GPCR downstream signalling | 7.559110e-01 | 0.122 |
| R-HSA-72172 | mRNA Splicing | 7.582534e-01 | 0.120 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.605190e-01 | 0.119 |
| R-HSA-418346 | Platelet homeostasis | 7.634374e-01 | 0.117 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.663204e-01 | 0.116 |
| R-HSA-69239 | Synthesis of DNA | 7.663204e-01 | 0.116 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.663204e-01 | 0.116 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.663204e-01 | 0.116 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.691684e-01 | 0.114 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.691684e-01 | 0.114 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.691684e-01 | 0.114 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.719819e-01 | 0.112 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.747613e-01 | 0.111 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.747613e-01 | 0.111 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.747613e-01 | 0.111 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.802193e-01 | 0.108 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.802193e-01 | 0.108 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.828988e-01 | 0.106 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.828988e-01 | 0.106 |
| R-HSA-9748784 | Drug ADME | 7.871597e-01 | 0.104 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.907437e-01 | 0.102 |
| R-HSA-8957322 | Metabolism of steroids | 7.911793e-01 | 0.102 |
| R-HSA-8951664 | Neddylation | 7.929460e-01 | 0.101 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.932955e-01 | 0.101 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.958164e-01 | 0.099 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.958164e-01 | 0.099 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.007666e-01 | 0.096 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.022831e-01 | 0.096 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.031968e-01 | 0.095 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.031968e-01 | 0.095 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.094832e-01 | 0.092 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.103118e-01 | 0.091 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.103118e-01 | 0.091 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.149123e-01 | 0.089 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.194019e-01 | 0.087 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.194019e-01 | 0.087 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.194019e-01 | 0.087 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.259203e-01 | 0.083 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.259338e-01 | 0.083 |
| R-HSA-157118 | Signaling by NOTCH | 8.264751e-01 | 0.083 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.335354e-01 | 0.079 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.479360e-01 | 0.072 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.483330e-01 | 0.071 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.604730e-01 | 0.065 |
| R-HSA-2187338 | Visual phototransduction | 8.671695e-01 | 0.062 |
| R-HSA-166520 | Signaling by NTRKs | 8.687931e-01 | 0.061 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.687931e-01 | 0.061 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.735462e-01 | 0.059 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.750922e-01 | 0.058 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.750922e-01 | 0.058 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.750922e-01 | 0.058 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.781280e-01 | 0.056 |
| R-HSA-1643685 | Disease | 8.800951e-01 | 0.055 |
| R-HSA-9711097 | Cellular response to starvation | 8.839811e-01 | 0.054 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.839811e-01 | 0.054 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.917438e-01 | 0.050 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.922405e-01 | 0.050 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.961480e-01 | 0.048 |
| R-HSA-611105 | Respiratory electron transport | 9.104181e-01 | 0.041 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.188297e-01 | 0.037 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.236829e-01 | 0.034 |
| R-HSA-1474244 | Extracellular matrix organization | 9.285777e-01 | 0.032 |
| R-HSA-428157 | Sphingolipid metabolism | 9.325401e-01 | 0.030 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.341848e-01 | 0.030 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.341848e-01 | 0.030 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.341848e-01 | 0.030 |
| R-HSA-6805567 | Keratinization | 9.373554e-01 | 0.028 |
| R-HSA-397014 | Muscle contraction | 9.418286e-01 | 0.026 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.600633e-01 | 0.018 |
| R-HSA-211859 | Biological oxidations | 9.629295e-01 | 0.016 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.629452e-01 | 0.016 |
| R-HSA-418594 | G alpha (i) signalling events | 9.676526e-01 | 0.014 |
| R-HSA-8978868 | Fatty acid metabolism | 9.676526e-01 | 0.014 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.690445e-01 | 0.014 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.709041e-01 | 0.013 |
| R-HSA-72766 | Translation | 9.743424e-01 | 0.011 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.775753e-01 | 0.010 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.794415e-01 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 9.795556e-01 | 0.009 |
| R-HSA-500792 | GPCR ligand binding | 9.802076e-01 | 0.009 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.882507e-01 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.937018e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.960347e-01 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 9.969926e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.989080e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999524e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999979e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.825 | 0.160 | 2 | 0.828 |
GRK1 |
0.817 | 0.241 | -2 | 0.732 |
CAMK2G |
0.816 | 0.223 | 2 | 0.846 |
DSTYK |
0.814 | 0.104 | 2 | 0.850 |
IKKB |
0.809 | 0.064 | -2 | 0.673 |
MOS |
0.808 | 0.083 | 1 | 0.884 |
FAM20C |
0.806 | 0.139 | 2 | 0.659 |
GRK6 |
0.806 | 0.218 | 1 | 0.872 |
TGFBR1 |
0.805 | 0.206 | -2 | 0.817 |
CLK3 |
0.805 | 0.089 | 1 | 0.828 |
PRPK |
0.805 | -0.008 | -1 | 0.810 |
CAMK2B |
0.805 | 0.201 | 2 | 0.834 |
IKKA |
0.802 | 0.106 | -2 | 0.674 |
GCN2 |
0.802 | -0.094 | 2 | 0.764 |
BMPR2 |
0.800 | -0.014 | -2 | 0.840 |
CDC7 |
0.800 | -0.050 | 1 | 0.837 |
ALK2 |
0.799 | 0.223 | -2 | 0.818 |
CK2A2 |
0.799 | 0.356 | 1 | 0.737 |
TBK1 |
0.798 | -0.058 | 1 | 0.767 |
PLK1 |
0.798 | 0.134 | -2 | 0.827 |
NDR2 |
0.798 | 0.022 | -3 | 0.806 |
GRK7 |
0.798 | 0.231 | 1 | 0.823 |
PIM3 |
0.797 | 0.017 | -3 | 0.789 |
BMPR1B |
0.797 | 0.147 | 1 | 0.799 |
RAF1 |
0.797 | -0.099 | 1 | 0.851 |
ALK4 |
0.796 | 0.135 | -2 | 0.829 |
IKKE |
0.796 | -0.054 | 1 | 0.761 |
PDHK4 |
0.795 | -0.157 | 1 | 0.869 |
LATS2 |
0.795 | 0.073 | -5 | 0.737 |
NEK6 |
0.795 | -0.047 | -2 | 0.824 |
ULK2 |
0.795 | -0.124 | 2 | 0.732 |
NEK7 |
0.795 | -0.072 | -3 | 0.843 |
MTOR |
0.794 | -0.108 | 1 | 0.812 |
GRK5 |
0.794 | 0.014 | -3 | 0.845 |
TGFBR2 |
0.793 | -0.034 | -2 | 0.818 |
GRK4 |
0.793 | 0.055 | -2 | 0.786 |
CAMK1B |
0.793 | -0.040 | -3 | 0.830 |
PLK3 |
0.793 | 0.141 | 2 | 0.760 |
CAMK2D |
0.793 | 0.059 | -3 | 0.812 |
ACVR2A |
0.792 | 0.123 | -2 | 0.813 |
CAMK2A |
0.792 | 0.125 | 2 | 0.851 |
SKMLCK |
0.792 | 0.019 | -2 | 0.742 |
MAPKAPK2 |
0.792 | 0.088 | -3 | 0.681 |
KIS |
0.792 | 0.029 | 1 | 0.671 |
ACVR2B |
0.791 | 0.124 | -2 | 0.816 |
HUNK |
0.791 | -0.049 | 2 | 0.740 |
MLK1 |
0.790 | -0.084 | 2 | 0.778 |
ULK1 |
0.790 | -0.091 | -3 | 0.802 |
PDHK1 |
0.790 | -0.154 | 1 | 0.862 |
CK2A1 |
0.789 | 0.312 | 1 | 0.717 |
RIPK3 |
0.789 | -0.121 | 3 | 0.574 |
ERK5 |
0.789 | -0.027 | 1 | 0.813 |
WNK1 |
0.788 | -0.054 | -2 | 0.760 |
PKN3 |
0.787 | -0.044 | -3 | 0.784 |
BMPR1A |
0.787 | 0.142 | 1 | 0.779 |
NLK |
0.787 | -0.113 | 1 | 0.818 |
CDKL1 |
0.786 | -0.058 | -3 | 0.741 |
PIM1 |
0.786 | 0.034 | -3 | 0.745 |
ATR |
0.786 | -0.073 | 1 | 0.801 |
CHAK2 |
0.786 | -0.054 | -1 | 0.838 |
NIK |
0.785 | -0.116 | -3 | 0.861 |
MST4 |
0.785 | -0.056 | 2 | 0.802 |
BCKDK |
0.785 | -0.089 | -1 | 0.704 |
ATM |
0.785 | 0.020 | 1 | 0.720 |
DLK |
0.785 | -0.054 | 1 | 0.864 |
RSK2 |
0.784 | -0.012 | -3 | 0.722 |
PRKD1 |
0.784 | -0.035 | -3 | 0.762 |
MAPKAPK3 |
0.783 | -0.011 | -3 | 0.735 |
ANKRD3 |
0.783 | -0.129 | 1 | 0.871 |
CAMLCK |
0.783 | -0.070 | -2 | 0.743 |
LATS1 |
0.782 | 0.061 | -3 | 0.815 |
WNK3 |
0.782 | -0.186 | 1 | 0.830 |
DAPK2 |
0.781 | -0.103 | -3 | 0.836 |
NDR1 |
0.781 | -0.081 | -3 | 0.805 |
NUAK2 |
0.780 | -0.088 | -3 | 0.813 |
PKCD |
0.780 | -0.050 | 2 | 0.759 |
NEK9 |
0.780 | -0.132 | 2 | 0.769 |
TTBK2 |
0.780 | -0.072 | 2 | 0.632 |
MARK4 |
0.780 | -0.112 | 4 | 0.516 |
TSSK2 |
0.780 | -0.062 | -5 | 0.830 |
PRKD2 |
0.779 | -0.028 | -3 | 0.729 |
MASTL |
0.779 | -0.189 | -2 | 0.739 |
AMPKA1 |
0.779 | -0.086 | -3 | 0.830 |
SRPK1 |
0.778 | -0.031 | -3 | 0.681 |
CDKL5 |
0.777 | -0.067 | -3 | 0.729 |
PKR |
0.777 | -0.037 | 1 | 0.860 |
MLK3 |
0.777 | -0.076 | 2 | 0.716 |
TSSK1 |
0.775 | -0.079 | -3 | 0.845 |
PKN2 |
0.775 | -0.103 | -3 | 0.814 |
P90RSK |
0.775 | -0.064 | -3 | 0.718 |
RIPK1 |
0.775 | -0.173 | 1 | 0.835 |
PKACG |
0.775 | -0.050 | -2 | 0.616 |
MLK4 |
0.774 | -0.073 | 2 | 0.693 |
MEK1 |
0.774 | -0.103 | 2 | 0.787 |
MLK2 |
0.774 | -0.177 | 2 | 0.762 |
TLK2 |
0.773 | -0.023 | 1 | 0.781 |
ICK |
0.773 | -0.079 | -3 | 0.778 |
YSK4 |
0.773 | -0.097 | 1 | 0.806 |
P70S6KB |
0.773 | -0.070 | -3 | 0.764 |
CAMK4 |
0.773 | -0.086 | -3 | 0.809 |
PAK1 |
0.773 | -0.032 | -2 | 0.665 |
HIPK4 |
0.772 | -0.088 | 1 | 0.760 |
MSK2 |
0.772 | -0.044 | -3 | 0.680 |
CDK8 |
0.772 | -0.054 | 1 | 0.642 |
SRPK2 |
0.771 | -0.037 | -3 | 0.610 |
GRK2 |
0.771 | -0.006 | -2 | 0.661 |
MSK1 |
0.771 | -0.007 | -3 | 0.689 |
IRE1 |
0.771 | -0.175 | 1 | 0.818 |
RSK3 |
0.771 | -0.089 | -3 | 0.708 |
PLK2 |
0.770 | 0.094 | -3 | 0.775 |
PLK4 |
0.770 | -0.064 | 2 | 0.597 |
DNAPK |
0.770 | 0.035 | 1 | 0.641 |
MNK2 |
0.770 | -0.053 | -2 | 0.682 |
CLK4 |
0.770 | -0.021 | -3 | 0.733 |
MEKK3 |
0.770 | -0.045 | 1 | 0.831 |
NEK2 |
0.770 | -0.091 | 2 | 0.742 |
BRAF |
0.770 | -0.012 | -4 | 0.855 |
AMPKA2 |
0.769 | -0.096 | -3 | 0.796 |
AURC |
0.769 | -0.038 | -2 | 0.543 |
IRE2 |
0.769 | -0.147 | 2 | 0.713 |
NUAK1 |
0.769 | -0.092 | -3 | 0.766 |
VRK2 |
0.769 | -0.233 | 1 | 0.892 |
RSK4 |
0.768 | -0.006 | -3 | 0.692 |
PERK |
0.768 | -0.093 | -2 | 0.814 |
CLK2 |
0.768 | 0.035 | -3 | 0.706 |
JNK3 |
0.767 | 0.004 | 1 | 0.629 |
PKCG |
0.767 | -0.083 | 2 | 0.711 |
PRKX |
0.767 | 0.038 | -3 | 0.659 |
PKCB |
0.767 | -0.068 | 2 | 0.701 |
GSK3A |
0.767 | -0.013 | 4 | 0.283 |
PAK3 |
0.767 | -0.098 | -2 | 0.665 |
NIM1 |
0.767 | -0.148 | 3 | 0.599 |
CK1E |
0.766 | 0.006 | -3 | 0.575 |
JNK2 |
0.766 | 0.007 | 1 | 0.580 |
SRPK3 |
0.766 | -0.060 | -3 | 0.656 |
PKACB |
0.765 | -0.003 | -2 | 0.562 |
CDK1 |
0.765 | -0.027 | 1 | 0.605 |
MYLK4 |
0.765 | -0.065 | -2 | 0.652 |
DYRK2 |
0.765 | -0.051 | 1 | 0.677 |
DRAK1 |
0.764 | -0.075 | 1 | 0.769 |
PAK2 |
0.764 | -0.084 | -2 | 0.652 |
CDK19 |
0.764 | -0.057 | 1 | 0.599 |
PKCZ |
0.764 | -0.095 | 2 | 0.722 |
MNK1 |
0.764 | -0.052 | -2 | 0.694 |
PHKG1 |
0.764 | -0.138 | -3 | 0.807 |
AURB |
0.764 | -0.054 | -2 | 0.543 |
GAK |
0.763 | 0.075 | 1 | 0.885 |
MELK |
0.763 | -0.126 | -3 | 0.783 |
CLK1 |
0.763 | -0.028 | -3 | 0.710 |
CDK2 |
0.763 | -0.048 | 1 | 0.714 |
TLK1 |
0.763 | -0.068 | -2 | 0.819 |
MAPKAPK5 |
0.763 | -0.095 | -3 | 0.668 |
GRK3 |
0.763 | 0.017 | -2 | 0.627 |
HRI |
0.763 | -0.154 | -2 | 0.817 |
PKCA |
0.763 | -0.089 | 2 | 0.698 |
CHK1 |
0.763 | -0.062 | -3 | 0.801 |
PASK |
0.763 | 0.015 | -3 | 0.804 |
GSK3B |
0.763 | -0.064 | 4 | 0.269 |
AURA |
0.763 | -0.035 | -2 | 0.528 |
PKCH |
0.762 | -0.103 | 2 | 0.693 |
PRP4 |
0.762 | -0.002 | -3 | 0.776 |
PRKD3 |
0.762 | -0.082 | -3 | 0.694 |
MARK2 |
0.762 | -0.116 | 4 | 0.446 |
NEK5 |
0.761 | -0.106 | 1 | 0.842 |
CHAK1 |
0.761 | -0.178 | 2 | 0.696 |
PAK6 |
0.761 | -0.043 | -2 | 0.586 |
SMG1 |
0.761 | -0.103 | 1 | 0.743 |
P38A |
0.760 | -0.055 | 1 | 0.685 |
P38B |
0.760 | -0.027 | 1 | 0.619 |
CDK7 |
0.760 | -0.088 | 1 | 0.640 |
BRSK1 |
0.760 | -0.104 | -3 | 0.760 |
MEKK1 |
0.760 | -0.157 | 1 | 0.840 |
ZAK |
0.759 | -0.145 | 1 | 0.829 |
TTBK1 |
0.759 | -0.094 | 2 | 0.570 |
CK1D |
0.759 | 0.012 | -3 | 0.529 |
QSK |
0.759 | -0.134 | 4 | 0.489 |
ERK2 |
0.759 | -0.064 | 1 | 0.648 |
MARK3 |
0.759 | -0.113 | 4 | 0.463 |
PKG2 |
0.759 | -0.068 | -2 | 0.553 |
SNRK |
0.758 | -0.190 | 2 | 0.665 |
CDK13 |
0.758 | -0.069 | 1 | 0.616 |
CDK5 |
0.758 | -0.069 | 1 | 0.661 |
MEKK2 |
0.758 | -0.134 | 2 | 0.752 |
CAMK1G |
0.758 | -0.084 | -3 | 0.728 |
ERK1 |
0.757 | -0.047 | 1 | 0.596 |
QIK |
0.757 | -0.207 | -3 | 0.821 |
DCAMKL1 |
0.757 | -0.063 | -3 | 0.761 |
CDK3 |
0.757 | -0.005 | 1 | 0.545 |
MEK5 |
0.756 | -0.257 | 2 | 0.771 |
WNK4 |
0.756 | -0.151 | -2 | 0.752 |
P38G |
0.756 | -0.029 | 1 | 0.517 |
SIK |
0.755 | -0.138 | -3 | 0.737 |
BRSK2 |
0.755 | -0.158 | -3 | 0.801 |
SGK3 |
0.755 | -0.056 | -3 | 0.724 |
IRAK4 |
0.755 | -0.165 | 1 | 0.823 |
DCAMKL2 |
0.754 | -0.062 | -3 | 0.790 |
MARK1 |
0.754 | -0.132 | 4 | 0.483 |
TAO3 |
0.754 | -0.087 | 1 | 0.823 |
DYRK4 |
0.754 | -0.017 | 1 | 0.596 |
CAMKK1 |
0.754 | -0.089 | -2 | 0.682 |
SMMLCK |
0.754 | -0.091 | -3 | 0.778 |
CK1A2 |
0.754 | -0.004 | -3 | 0.526 |
PIM2 |
0.754 | -0.057 | -3 | 0.705 |
SSTK |
0.754 | -0.099 | 4 | 0.485 |
CK1G1 |
0.754 | -0.046 | -3 | 0.564 |
MST3 |
0.753 | -0.109 | 2 | 0.776 |
PINK1 |
0.753 | -0.179 | 1 | 0.826 |
CDK18 |
0.753 | -0.071 | 1 | 0.580 |
HIPK1 |
0.752 | -0.056 | 1 | 0.702 |
HIPK2 |
0.752 | -0.036 | 1 | 0.579 |
NEK8 |
0.751 | -0.170 | 2 | 0.771 |
PKACA |
0.751 | -0.023 | -2 | 0.507 |
PHKG2 |
0.751 | -0.127 | -3 | 0.786 |
CDK17 |
0.750 | -0.071 | 1 | 0.528 |
CAMK1D |
0.750 | -0.039 | -3 | 0.666 |
CDK12 |
0.749 | -0.071 | 1 | 0.587 |
EEF2K |
0.749 | -0.068 | 3 | 0.637 |
NEK11 |
0.749 | -0.182 | 1 | 0.811 |
AKT2 |
0.748 | -0.080 | -3 | 0.644 |
DYRK1A |
0.748 | -0.077 | 1 | 0.712 |
PKCT |
0.748 | -0.125 | 2 | 0.696 |
LKB1 |
0.748 | -0.099 | -3 | 0.850 |
TAO2 |
0.748 | -0.134 | 2 | 0.797 |
CDK9 |
0.748 | -0.088 | 1 | 0.625 |
MPSK1 |
0.748 | -0.075 | 1 | 0.817 |
IRAK1 |
0.747 | -0.221 | -1 | 0.734 |
CAMKK2 |
0.747 | -0.124 | -2 | 0.662 |
PDHK3_TYR |
0.746 | 0.262 | 4 | 0.607 |
P38D |
0.746 | -0.027 | 1 | 0.515 |
ERK7 |
0.746 | -0.035 | 2 | 0.529 |
DAPK3 |
0.746 | -0.059 | -3 | 0.770 |
MST2 |
0.746 | -0.126 | 1 | 0.822 |
DYRK1B |
0.745 | -0.054 | 1 | 0.638 |
GCK |
0.745 | -0.082 | 1 | 0.800 |
JNK1 |
0.745 | -0.020 | 1 | 0.584 |
HIPK3 |
0.743 | -0.101 | 1 | 0.693 |
DYRK3 |
0.743 | -0.068 | 1 | 0.706 |
NEK4 |
0.743 | -0.169 | 1 | 0.804 |
PKCI |
0.742 | -0.123 | 2 | 0.702 |
TAK1 |
0.742 | -0.090 | 1 | 0.805 |
PAK5 |
0.742 | -0.076 | -2 | 0.529 |
PDHK4_TYR |
0.741 | 0.176 | 2 | 0.857 |
P70S6K |
0.741 | -0.110 | -3 | 0.663 |
TNIK |
0.740 | -0.095 | 3 | 0.652 |
CDK16 |
0.740 | -0.065 | 1 | 0.548 |
MAP3K15 |
0.740 | -0.168 | 1 | 0.806 |
VRK1 |
0.740 | -0.166 | 2 | 0.780 |
MST1 |
0.740 | -0.107 | 1 | 0.815 |
PDK1 |
0.740 | -0.140 | 1 | 0.811 |
NEK1 |
0.740 | -0.143 | 1 | 0.827 |
PKCE |
0.739 | -0.089 | 2 | 0.693 |
DAPK1 |
0.739 | -0.063 | -3 | 0.748 |
AKT1 |
0.739 | -0.081 | -3 | 0.670 |
CDK14 |
0.739 | -0.098 | 1 | 0.629 |
MINK |
0.738 | -0.145 | 1 | 0.804 |
PAK4 |
0.738 | -0.076 | -2 | 0.539 |
MAP2K6_TYR |
0.738 | 0.130 | -1 | 0.829 |
STK33 |
0.738 | -0.118 | 2 | 0.584 |
TTK |
0.737 | -0.045 | -2 | 0.835 |
PDHK1_TYR |
0.737 | 0.127 | -1 | 0.867 |
RIPK2 |
0.736 | -0.211 | 1 | 0.777 |
LRRK2 |
0.736 | -0.188 | 2 | 0.792 |
HGK |
0.736 | -0.162 | 3 | 0.642 |
MEKK6 |
0.736 | -0.226 | 1 | 0.820 |
ALPHAK3 |
0.735 | 0.009 | -1 | 0.756 |
SLK |
0.735 | -0.088 | -2 | 0.624 |
BMPR2_TYR |
0.735 | 0.075 | -1 | 0.856 |
MEK2 |
0.733 | -0.217 | 2 | 0.744 |
HPK1 |
0.733 | -0.132 | 1 | 0.785 |
CDK10 |
0.733 | -0.083 | 1 | 0.608 |
EPHA6 |
0.733 | 0.033 | -1 | 0.861 |
MAP2K4_TYR |
0.733 | 0.007 | -1 | 0.816 |
LOK |
0.732 | -0.147 | -2 | 0.671 |
MAP2K7_TYR |
0.732 | -0.034 | 2 | 0.826 |
TESK1_TYR |
0.732 | -0.075 | 3 | 0.687 |
MRCKA |
0.731 | -0.075 | -3 | 0.734 |
ROCK2 |
0.730 | -0.062 | -3 | 0.761 |
KHS1 |
0.730 | -0.110 | 1 | 0.786 |
PBK |
0.730 | -0.041 | 1 | 0.816 |
EPHA4 |
0.730 | 0.073 | 2 | 0.763 |
OSR1 |
0.730 | -0.092 | 2 | 0.735 |
PINK1_TYR |
0.729 | -0.078 | 1 | 0.872 |
PKN1 |
0.729 | -0.125 | -3 | 0.689 |
KHS2 |
0.729 | -0.091 | 1 | 0.787 |
MRCKB |
0.729 | -0.075 | -3 | 0.709 |
CHK2 |
0.728 | -0.098 | -3 | 0.593 |
CDK6 |
0.728 | -0.088 | 1 | 0.600 |
HASPIN |
0.728 | -0.025 | -1 | 0.713 |
BIKE |
0.728 | 0.029 | 1 | 0.780 |
CAMK1A |
0.728 | -0.083 | -3 | 0.606 |
YES1 |
0.728 | 0.010 | -1 | 0.826 |
BUB1 |
0.727 | -0.070 | -5 | 0.762 |
PKMYT1_TYR |
0.727 | -0.132 | 3 | 0.667 |
SRMS |
0.727 | 0.063 | 1 | 0.873 |
FYN |
0.727 | 0.101 | -1 | 0.841 |
EPHB4 |
0.727 | -0.013 | -1 | 0.809 |
TXK |
0.727 | 0.040 | 1 | 0.853 |
YSK1 |
0.726 | -0.176 | 2 | 0.747 |
SGK1 |
0.726 | -0.056 | -3 | 0.555 |
BLK |
0.726 | 0.044 | -1 | 0.863 |
LCK |
0.725 | 0.013 | -1 | 0.852 |
CDK4 |
0.725 | -0.089 | 1 | 0.576 |
HCK |
0.725 | -0.006 | -1 | 0.836 |
DMPK1 |
0.725 | -0.042 | -3 | 0.735 |
MAK |
0.724 | -0.045 | -2 | 0.619 |
RET |
0.724 | -0.105 | 1 | 0.840 |
FER |
0.724 | 0.026 | 1 | 0.883 |
CSF1R |
0.723 | -0.086 | 3 | 0.633 |
EPHB2 |
0.723 | 0.026 | -1 | 0.800 |
FGR |
0.723 | -0.039 | 1 | 0.893 |
INSRR |
0.723 | -0.005 | 3 | 0.596 |
ABL2 |
0.723 | -0.049 | -1 | 0.794 |
MST1R |
0.723 | -0.150 | 3 | 0.644 |
YANK3 |
0.722 | -0.059 | 2 | 0.387 |
ASK1 |
0.722 | -0.125 | 1 | 0.802 |
EPHB3 |
0.722 | 0.008 | -1 | 0.799 |
SBK |
0.722 | -0.048 | -3 | 0.519 |
NEK3 |
0.721 | -0.225 | 1 | 0.788 |
EPHB1 |
0.721 | -0.014 | 1 | 0.869 |
AKT3 |
0.721 | -0.087 | -3 | 0.567 |
PKG1 |
0.721 | -0.098 | -2 | 0.488 |
DDR1 |
0.721 | -0.099 | 4 | 0.546 |
TYK2 |
0.721 | -0.136 | 1 | 0.837 |
CK1A |
0.720 | -0.021 | -3 | 0.443 |
TYRO3 |
0.720 | -0.154 | 3 | 0.625 |
JAK2 |
0.720 | -0.115 | 1 | 0.828 |
KIT |
0.719 | -0.057 | 3 | 0.632 |
MOK |
0.719 | -0.082 | 1 | 0.722 |
JAK3 |
0.719 | -0.084 | 1 | 0.827 |
FGFR2 |
0.718 | -0.043 | 3 | 0.629 |
LIMK2_TYR |
0.718 | -0.146 | -3 | 0.875 |
ROS1 |
0.717 | -0.161 | 3 | 0.598 |
FLT3 |
0.717 | -0.091 | 3 | 0.624 |
EPHA7 |
0.717 | 0.001 | 2 | 0.753 |
MET |
0.717 | -0.054 | 3 | 0.628 |
EPHA5 |
0.716 | 0.041 | 2 | 0.759 |
MERTK |
0.716 | -0.017 | 3 | 0.623 |
TNK2 |
0.716 | -0.079 | 3 | 0.610 |
ITK |
0.716 | -0.050 | -1 | 0.792 |
PTK2 |
0.716 | 0.087 | -1 | 0.815 |
ROCK1 |
0.716 | -0.081 | -3 | 0.731 |
FLT1 |
0.715 | -0.011 | -1 | 0.827 |
ABL1 |
0.715 | -0.086 | -1 | 0.785 |
EPHA3 |
0.715 | -0.024 | 2 | 0.738 |
LYN |
0.715 | -0.025 | 3 | 0.569 |
KDR |
0.715 | -0.097 | 3 | 0.615 |
ERBB2 |
0.715 | -0.036 | 1 | 0.839 |
LIMK1_TYR |
0.715 | -0.240 | 2 | 0.801 |
EPHA8 |
0.714 | 0.026 | -1 | 0.821 |
EGFR |
0.714 | 0.065 | 1 | 0.774 |
BMX |
0.713 | -0.028 | -1 | 0.722 |
FRK |
0.713 | -0.047 | -1 | 0.857 |
TEC |
0.713 | -0.059 | -1 | 0.727 |
AXL |
0.713 | -0.078 | 3 | 0.617 |
SRC |
0.713 | 0.021 | -1 | 0.822 |
TAO1 |
0.713 | -0.158 | 1 | 0.756 |
PDGFRB |
0.713 | -0.131 | 3 | 0.635 |
MYO3B |
0.713 | -0.165 | 2 | 0.757 |
TEK |
0.713 | -0.111 | 3 | 0.581 |
STLK3 |
0.713 | -0.132 | 1 | 0.788 |
FGFR3 |
0.712 | -0.024 | 3 | 0.617 |
FGFR1 |
0.712 | -0.106 | 3 | 0.619 |
SYK |
0.712 | 0.107 | -1 | 0.801 |
PTK2B |
0.712 | -0.011 | -1 | 0.763 |
NTRK1 |
0.711 | -0.044 | -1 | 0.751 |
CRIK |
0.711 | -0.072 | -3 | 0.650 |
MYO3A |
0.710 | -0.175 | 1 | 0.801 |
EPHA1 |
0.710 | -0.083 | 3 | 0.613 |
BTK |
0.709 | -0.136 | -1 | 0.741 |
EPHA2 |
0.709 | 0.038 | -1 | 0.774 |
AAK1 |
0.708 | 0.043 | 1 | 0.677 |
FLT4 |
0.708 | -0.091 | 3 | 0.600 |
ERBB4 |
0.707 | 0.055 | 1 | 0.779 |
CK1G3 |
0.707 | -0.012 | -3 | 0.395 |
FGFR4 |
0.707 | 0.010 | -1 | 0.745 |
LTK |
0.707 | -0.097 | 3 | 0.601 |
TNK1 |
0.706 | -0.142 | 3 | 0.610 |
NTRK2 |
0.705 | -0.120 | 3 | 0.612 |
DDR2 |
0.705 | -0.034 | 3 | 0.588 |
ALK |
0.705 | -0.127 | 3 | 0.583 |
JAK1 |
0.705 | -0.123 | 1 | 0.781 |
NTRK3 |
0.705 | -0.050 | -1 | 0.705 |
CSK |
0.704 | -0.032 | 2 | 0.752 |
PDGFRA |
0.703 | -0.212 | 3 | 0.634 |
INSR |
0.703 | -0.108 | 3 | 0.569 |
TNNI3K_TYR |
0.701 | -0.137 | 1 | 0.853 |
MATK |
0.701 | -0.060 | -1 | 0.731 |
NEK10_TYR |
0.701 | -0.137 | 1 | 0.697 |
WEE1_TYR |
0.701 | -0.119 | -1 | 0.707 |
PTK6 |
0.701 | -0.132 | -1 | 0.700 |
IGF1R |
0.700 | -0.021 | 3 | 0.526 |
CK1G2 |
0.696 | -0.010 | -3 | 0.488 |
YANK2 |
0.690 | -0.085 | 2 | 0.411 |
MUSK |
0.690 | -0.100 | 1 | 0.774 |
ZAP70 |
0.687 | 0.029 | -1 | 0.710 |
FES |
0.685 | -0.066 | -1 | 0.694 |