Motif 546 (n=232)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5YM69 | ARHGEF35 | S184 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| A6H8Y1 | BDP1 | S1317 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NDB9 | PALM3 | S550 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A6NHT5 | HMX3 | S171 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| A6NIH7 | UNC119B | S119 | ochoa | Protein unc-119 homolog B | Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. {ECO:0000269|PubMed:22085962}. |
| A6NKG5 | RTL1 | S1030 | ochoa | Retrotransposon-like protein 1 (Mammalian retrotransposon derived protein 1) (Paternally expressed gene 11 protein) (Retrotransposon-derived protein PEG11) | Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. {ECO:0000250}. |
| F8WAN1 | SPECC1L-ADORA2A | S220 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H3BU86 | STX16-NPEPL1 | S115 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| H7C1W4 | None | S397 | ochoa | Uncharacterized protein | None |
| O00409 | FOXN3 | S448 | ochoa | Forkhead box protein N3 (Checkpoint suppressor 1) | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. |
| O14662 | STX16 | S115 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O15014 | ZNF609 | S849 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15047 | SETD1A | S508 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15397 | IPO8 | S595 | ochoa | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
| O43159 | RRP8 | S62 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O43493 | TGOLN2 | S315 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43719 | HTATSF1 | S642 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O75643 | SNRNP200 | S207 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75691 | UTP20 | S2601 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O75717 | WDHD1 | S393 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O75717 | WDHD1 | S1090 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O75822 | EIF3J | S127 | ochoa|psp | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O75864 | PPP1R37 | S669 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O94782 | USP1 | S466 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94966 | USP19 | S480 | ochoa | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816). {ECO:0000250|UniProtKB:Q3UJD6, ECO:0000250|UniProtKB:Q6J1Y9, ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:24356957, ECO:0000269|PubMed:31127032, ECO:0000269|PubMed:33094816, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:38943386}. |
| O95551 | TDP2 | S60 | psp | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| O95714 | HERC2 | S2928 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95810 | CAVIN2 | S177 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P00519 | ABL1 | S446 | psp | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P01042 | KNG1 | S391 | psp | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| P04075 | ALDOA | S46 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05060 | CHGB | S182 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06753 | TPM3 | S189 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P10645 | CHGA | S300 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P10645 | CHGA | S322 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11137 | MAP2 | S1398 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12830 | CDH1 | Y755 | ochoa|psp | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P18583 | SON | S1509 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20042 | EIF2S2 | S105 | ochoa | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P22059 | OSBP | S190 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22223 | CDH3 | Y701 | ochoa | Cadherin-3 (Placental cadherin) (P-cadherin) | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| P25786 | PSMA1 | S230 | ochoa | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P28715 | ERCC5 | S156 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29084 | GTF2E2 | S227 | ochoa | Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}. |
| P29375 | KDM5A | S1111 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P30533 | LRPAP1 | S247 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P33241 | LSP1 | S130 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35579 | MYH9 | S45 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P41227 | NAA10 | S213 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P43121 | MCAM | S290 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P46821 | MAP1B | S1144 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S548 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S913 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S934 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49368 | CCT3 | S333 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49662 | CASP4 | S280 | ochoa | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:32581219, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}. |
| P49736 | MCM2 | Y137 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P52732 | KIF11 | S1033 | ochoa|psp | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P54132 | BLM | S1310 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55201 | BRPF1 | S120 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P56524 | HDAC4 | S565 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P58317 | ZNF121 | S87 | ochoa | Zinc finger protein 121 (Zinc finger protein 20) | May be involved in transcriptional regulation. |
| P62258 | YWHAE | S233 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P82094 | TMF1 | S142 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01484 | ANK2 | S1732 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02224 | CENPE | S611 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q02952 | AKAP12 | S660 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05682 | CALD1 | S252 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q06265 | EXOSC9 | S306 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q07157 | TJP1 | Y1346 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12774 | ARHGEF5 | S184 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | S674 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S993 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13029 | PRDM2 | S471 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13123 | IK | S417 | ochoa | Protein Red (Cytokine IK) (IK factor) (Protein RER) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}. |
| Q13442 | PDAP1 | S60 | ochoa | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}. |
| Q13546 | RIPK1 | S291 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13576 | IQGAP2 | S685 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q14524 | SCN5A | S671 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14554 | PDIA5 | S213 | ochoa | Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) | None |
| Q14684 | RRP1B | S245 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14766 | LTBP1 | S1616 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14789 | GOLGB1 | S1792 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q147X3 | NAA30 | S39 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q15021 | NCAPD2 | S972 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15311 | RALBP1 | S509 | psp | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15468 | STIL | S1132 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q16352 | INA | S464 | ochoa | Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) | Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). {ECO:0000250|UniProtKB:P46660}. |
| Q16543 | CDC37 | S97 | psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16665 | HIF1A | S31 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16891 | IMMT | S193 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q53T59 | HS1BP3 | S302 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5F1R6 | DNAJC21 | S283 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5F1R6 | DNAJC21 | S302 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5H9R7 | PPP6R3 | S617 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5SSJ5 | HP1BP3 | S76 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T200 | ZC3H13 | S1455 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T4S7 | UBR4 | T4463 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T8D3 | ACBD5 | S200 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
| Q5UIP0 | RIF1 | S1554 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VU43 | PDE4DIP | S292 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VV52 | ZNF691 | S75 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5VZK9 | CARMIL1 | S1131 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q5VZP5 | STYXL2 | S1065 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q63HN8 | RNF213 | S69 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q641Q2 | WASHC2A | S663 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q658Y4 | FAM91A1 | S694 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q659C4 | LARP1B | S432 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q69YQ0 | SPECC1L | S220 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6P6B1 | ERICH5 | S354 | ochoa | Glutamate-rich protein 5 | None |
| Q6PJG2 | MIDEAS | S894 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6PKG0 | LARP1 | S627 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UB99 | ANKRD11 | S1279 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UX04 | CWC27 | S206 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6VY07 | PACS1 | S379 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q76FK4 | NOL8 | S331 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L5D6 | GET4 | S308 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z422 | SZRD1 | S107 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q7Z5K2 | WAPL | S95 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6Z7 | HUWE1 | S2372 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86SQ0 | PHLDB2 | S489 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86T65 | DAAM2 | S1015 | ochoa | Disheveled-associated activator of morphogenesis 2 | Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676). {ECO:0000250|UniProtKB:Q80U19, ECO:0000269|PubMed:33232676}. |
| Q86TI0 | TBC1D1 | S263 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S682 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UV5 | USP48 | S888 | ochoa | Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability (PubMed:34445214). In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death (PubMed:35913642). Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms (PubMed:36293380). Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination (PubMed:36607699). {ECO:0000269|PubMed:16214042, ECO:0000269|PubMed:34059922, ECO:0000269|PubMed:34445214, ECO:0000269|PubMed:35913642, ECO:0000269|PubMed:36293380, ECO:0000269|PubMed:36607699}. |
| Q86UW6 | N4BP2 | S1325 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86V15 | CASZ1 | S130 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86VM9 | ZC3H18 | S67 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VY4 | TSPYL5 | S180 | ochoa | Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5) | Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}. |
| Q86WN1 | FCHSD1 | S444 | ochoa | F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) | Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}. |
| Q86Y82 | STX12 | S142 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q8IVF2 | AHNAK2 | S497 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S5542 | ochoa | Protein AHNAK2 | None |
| Q8IY81 | FTSJ3 | S356 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8N163 | CCAR2 | S569 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N183 | NDUFAF2 | S134 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8N3J3 | HROB | S619 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N3X1 | FNBP4 | S499 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NC51 | SERBP1 | S328 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCY6 | MSANTD4 | S106 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) | None |
| Q8NFC6 | BOD1L1 | S246 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHP6 | MOSPD2 | S273 | ochoa | Motile sperm domain-containing protein 2 | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}. |
| Q8TAQ2 | SMARCC2 | S745 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TDP1 | RNASEH2C | S102 | ochoa | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| Q8TF01 | PNISR | S290 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WVM7 | STAG1 | S20 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WYP5 | AHCTF1 | S1283 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92541 | RTF1 | S313 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92576 | PHF3 | S289 | ochoa | PHD finger protein 3 | None |
| Q92794 | KAT6A | S1104 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92889 | ERCC4 | S520 | ochoa | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}. |
| Q93073 | SECISBP2L | S885 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q93075 | TATDN2 | S454 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96AY2 | EME1 | S84 | ochoa | Structure-specific endonuclease subunit EME1 (Crossover junction endonuclease EME1) (Essential meiotic structure-specific endonuclease 1) (MMS4 homolog) (hMMS4) | Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME1 which is involved in the maintenance of genome stability. In the complex, EME1 is required for DNA cleavage, participating in DNA recognition and bending (PubMed:12686547, PubMed:12721304, PubMed:14617801, PubMed:17289582, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). MUS81-EME1 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24733841, PubMed:35290797). Active during prometaphase, MUS81-EME1 resolves mitotic recombination intermediates, including Holliday junctions, which form during homologous recombination (PubMed:14617801, PubMed:24813886). {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96CV9 | OPTN | S281 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96EB6 | SIRT1 | S569 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96GN5 | CDCA7L | S117 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96NL8 | CFAP418 | S65 | ochoa | Cilia- and flagella-associated protein 418 | May be involved in photoreceptor outer segment disk morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UJP5}. |
| Q96P48 | ARAP1 | S229 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q96RL1 | UIMC1 | S46 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RT1 | ERBIN | S598 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96S55 | WRNIP1 | S91 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q96ST3 | SIN3A | S832 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96T23 | RSF1 | S689 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T23 | RSF1 | S1345 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q9BQF6 | SENP7 | S444 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BVS4 | RIOK2 | S442 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BXK5 | BCL2L13 | S375 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXW6 | OSBPL1A | S499 | ochoa | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}. |
| Q9BXW9 | FANCD2 | S1423 | ochoa | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BZE4 | GTPBP4 | S472 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9C0B9 | ZCCHC2 | S489 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9C0G0 | ZNF407 | S356 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H1V8 | SLC6A17 | S665 | ochoa | Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) | Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. {ECO:0000250|UniProtKB:P31662}. |
| Q9H2P0 | ADNP | S740 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4L7 | SMARCAD1 | S57 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H4L7 | SMARCAD1 | S146 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H501 | ESF1 | S694 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H6A9 | PCNX3 | S96 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6T3 | RPAP3 | S116 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H7J1 | PPP1R3E | S33 | ochoa | Protein phosphatase 1 regulatory subunit 3E | Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. {ECO:0000269|PubMed:15752363}. |
| Q9HA90 | EFCC1 | S394 | ochoa | EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48) | None |
| Q9HAW4 | CLSPN | S83 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HC77 | CPAP | S316 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NPG3 | UBN1 | S493 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQS1 | AVEN | S94 | ochoa | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
| Q9NQT8 | KIF13B | S858 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQT8 | KIF13B | S1689 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NRL2 | BAZ1A | S702 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NTI5 | PDS5B | S1259 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NWB7 | IFT57 | Y168 | ochoa | Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2) | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}. |
| Q9NWZ8 | GEMIN8 | S117 | ochoa | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}. |
| Q9NYF5 | FAM13B | S818 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9NYQ6 | CELSR1 | S2889 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZB2 | FAM120A | S1023 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P0K7 | RAI14 | S624 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L2 | MARK1 | S444 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P1Y6 | PHRF1 | S936 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P287 | BCCIP | S42 | ochoa | BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333, ECO:0000269|PubMed:28394342}. |
| Q9P2D1 | CHD7 | S1577 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2I0 | CPSF2 | S419 | ochoa | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
| Q9UHK0 | NUFIP1 | S338 | ochoa | FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) | Binds RNA. {ECO:0000269|PubMed:10556305}. |
| Q9UHY8 | FEZ2 | S135 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UIF9 | BAZ2A | S1051 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UK61 | TASOR | S636 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKA4 | AKAP11 | S1493 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9ULX6 | AKAP8L | S552 | ochoa | A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) | Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}. |
| Q9UNS1 | TIMELESS | S1121 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UPS6 | SETD1B | S986 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPV0 | CEP164 | S383 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y266 | NUDC | S304 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y2F5 | ICE1 | S589 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2I7 | PIKFYVE | S475 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2J2 | EPB41L3 | S708 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3R5 | DOP1B | S650 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y4B5 | MTCL1 | S776 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y6I3 | EPN1 | S220 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6X4 | FAM169A | S378 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| Q9Y6X4 | FAM169A | S635 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| Q9Y6X9 | MORC2 | S743 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| R4GMW8 | BIVM-ERCC5 | S610 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q9Y4L1 | HYOU1 | S763 | Sugiyama | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| P13639 | EEF2 | S578 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P30085 | CMPK1 | S47 | Sugiyama | UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}. |
| P35269 | GTF2F1 | Y57 | Sugiyama | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P05771 | PRKCB | S311 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| Q14896 | MYBPC3 | S311 | ELM|EPSD|PSP | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q99250 | SCN2A | S1126 | SIGNOR | Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}. |
| P36871 | PGM1 | Y428 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| O95359 | TACC2 | S2522 | Sugiyama | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P42681 | TXK | S305 | Sugiyama | Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) | Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}. |
| Q5VSY0 | GKAP1 | S106 | SIGNOR|iPTMNet|EPSD | G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa) | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. {ECO:0000250|UniProtKB:Q9JMB0}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.000032 | 4.493 |
| R-HSA-5693538 | Homology Directed Repair | 0.000047 | 4.325 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.000018 | 4.753 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.001815 | 2.741 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.001815 | 2.741 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.001815 | 2.741 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.001815 | 2.741 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.001815 | 2.741 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.001815 | 2.741 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.001815 | 2.741 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.001815 | 2.741 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.001815 | 2.741 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.001815 | 2.741 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.001815 | 2.741 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.000537 | 3.270 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.001140 | 2.943 |
| R-HSA-68877 | Mitotic Prometaphase | 0.001870 | 2.728 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.001497 | 2.825 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.001712 | 2.766 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.001900 | 2.721 |
| R-HSA-69481 | G2/M Checkpoints | 0.000414 | 3.383 |
| R-HSA-1640170 | Cell Cycle | 0.000436 | 3.361 |
| R-HSA-73894 | DNA Repair | 0.000935 | 3.029 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.001709 | 2.767 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.001436 | 2.843 |
| R-HSA-5357801 | Programmed Cell Death | 0.000847 | 3.072 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.002787 | 2.555 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.002807 | 2.552 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.002852 | 2.545 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.003177 | 2.498 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.003326 | 2.478 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.003823 | 2.418 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.004300 | 2.367 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.004921 | 2.308 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.005119 | 2.291 |
| R-HSA-5218859 | Regulated Necrosis | 0.006842 | 2.165 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.006971 | 2.157 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.009296 | 2.032 |
| R-HSA-8849473 | PTK6 Expression | 0.010675 | 1.972 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.010149 | 1.994 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.010843 | 1.965 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.010853 | 1.964 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.012299 | 1.910 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.012787 | 1.893 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.012787 | 1.893 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.012787 | 1.893 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.014900 | 1.827 |
| R-HSA-176974 | Unwinding of DNA | 0.015066 | 1.822 |
| R-HSA-69242 | S Phase | 0.015291 | 1.816 |
| R-HSA-5620971 | Pyroptosis | 0.016116 | 1.793 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.017505 | 1.757 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.018710 | 1.728 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.018710 | 1.728 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.019096 | 1.719 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.020737 | 1.683 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.023010 | 1.638 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.023010 | 1.638 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.023010 | 1.638 |
| R-HSA-109581 | Apoptosis | 0.022584 | 1.646 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.021522 | 1.667 |
| R-HSA-68886 | M Phase | 0.023566 | 1.628 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.024552 | 1.610 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.025732 | 1.590 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.023793 | 1.624 |
| R-HSA-9948011 | CASP5 inflammasome assembly | 0.030334 | 1.518 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.031925 | 1.496 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.031925 | 1.496 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.030905 | 1.510 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.029654 | 1.528 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.034843 | 1.458 |
| R-HSA-201556 | Signaling by ALK | 0.034948 | 1.457 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.037623 | 1.425 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.045156 | 1.345 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.074125 | 1.130 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.074125 | 1.130 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.088280 | 1.054 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.102219 | 0.990 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.115946 | 0.936 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.142776 | 0.845 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.142776 | 0.845 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.142776 | 0.845 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.142776 | 0.845 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.168795 | 0.773 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.061535 | 1.211 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.181508 | 0.741 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.181508 | 0.741 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.069976 | 1.155 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.194028 | 0.712 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.194028 | 0.712 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.206356 | 0.685 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.206356 | 0.685 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.206356 | 0.685 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.218497 | 0.661 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.092555 | 1.034 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.230453 | 0.637 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.230453 | 0.637 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.242226 | 0.616 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.253820 | 0.595 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.253820 | 0.595 |
| R-HSA-390522 | Striated Muscle Contraction | 0.127050 | 0.896 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.265238 | 0.576 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.132199 | 0.879 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.137395 | 0.862 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.276481 | 0.558 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.276481 | 0.558 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.147918 | 0.830 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.097868 | 1.009 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.097868 | 1.009 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.309194 | 0.510 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.309194 | 0.510 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.309194 | 0.510 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.174871 | 0.757 |
| R-HSA-167161 | HIV Transcription Initiation | 0.174871 | 0.757 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.174871 | 0.757 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.107286 | 0.969 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.180354 | 0.744 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.319767 | 0.495 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.319767 | 0.495 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.319767 | 0.495 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.319767 | 0.495 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.319767 | 0.495 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.185863 | 0.731 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.196949 | 0.706 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.130541 | 0.884 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.202523 | 0.694 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.202523 | 0.694 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.202523 | 0.694 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.089367 | 1.049 |
| R-HSA-380287 | Centrosome maturation | 0.137488 | 0.862 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.350530 | 0.455 |
| R-HSA-9766229 | Degradation of CDH1 | 0.219344 | 0.659 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.360474 | 0.443 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.360474 | 0.443 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.236277 | 0.627 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.370265 | 0.431 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.241938 | 0.616 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.241938 | 0.616 |
| R-HSA-72649 | Translation initiation complex formation | 0.247606 | 0.606 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.379908 | 0.420 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.177739 | 0.750 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.177739 | 0.750 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.258953 | 0.587 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.189235 | 0.723 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.264630 | 0.577 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.168920 | 0.772 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.232966 | 0.633 |
| R-HSA-72172 | mRNA Splicing | 0.264382 | 0.578 |
| R-HSA-167172 | Transcription of the HIV genome | 0.326819 | 0.486 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.330180 | 0.481 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.330180 | 0.481 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.120366 | 0.919 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.176517 | 0.753 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.176517 | 0.753 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.287554 | 0.541 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.287554 | 0.541 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.088808 | 1.052 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.389403 | 0.410 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.106977 | 0.971 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.197002 | 0.706 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.132199 | 0.879 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.181549 | 0.741 |
| R-HSA-448706 | Interleukin-1 processing | 0.168795 | 0.773 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.309947 | 0.509 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.153239 | 0.815 |
| R-HSA-191650 | Regulation of gap junction activity | 0.088280 | 1.054 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.155886 | 0.807 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 0.230453 | 0.637 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.340433 | 0.468 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.350530 | 0.455 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.379908 | 0.420 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.379908 | 0.420 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.349138 | 0.457 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.241938 | 0.616 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.270307 | 0.568 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.292992 | 0.533 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.238599 | 0.622 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.121950 | 0.914 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.287554 | 0.541 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.298457 | 0.525 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.110502 | 0.957 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.230623 | 0.637 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.314431 | 0.502 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.133999 | 0.873 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.202523 | 0.694 |
| R-HSA-418990 | Adherens junctions interactions | 0.077295 | 1.112 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.389403 | 0.410 |
| R-HSA-421270 | Cell-cell junction organization | 0.127781 | 0.894 |
| R-HSA-75893 | TNF signaling | 0.258953 | 0.587 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.088280 | 1.054 |
| R-HSA-9930044 | Nuclear RNA decay | 0.121950 | 0.914 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.163991 | 0.785 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.350530 | 0.455 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.055125 | 1.259 |
| R-HSA-525793 | Myogenesis | 0.087885 | 1.056 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.245018 | 0.611 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.265238 | 0.576 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.097560 | 1.011 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.343580 | 0.464 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.343580 | 0.464 |
| R-HSA-446728 | Cell junction organization | 0.178831 | 0.748 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.216311 | 0.665 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.118405 | 0.927 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.253206 | 0.597 |
| R-HSA-844623 | The IPAF inflammasome | 0.074125 | 1.130 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.074125 | 1.130 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.088280 | 1.054 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.155886 | 0.807 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.181508 | 0.741 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.097296 | 1.012 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.102105 | 0.991 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.253820 | 0.595 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.066534 | 1.177 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.265238 | 0.576 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.309194 | 0.510 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.350530 | 0.455 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.360474 | 0.443 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.370265 | 0.431 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.370265 | 0.431 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.247606 | 0.606 |
| R-HSA-5617833 | Cilium Assembly | 0.106216 | 0.974 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.332419 | 0.478 |
| R-HSA-1500931 | Cell-Cell communication | 0.262454 | 0.581 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.142776 | 0.845 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.287554 | 0.541 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.319767 | 0.495 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.123724 | 0.908 |
| R-HSA-3295583 | TRP channels | 0.389403 | 0.410 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.106977 | 0.971 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.253820 | 0.595 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.389403 | 0.410 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.286297 | 0.543 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.076316 | 1.117 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.340433 | 0.468 |
| R-HSA-72312 | rRNA processing | 0.347744 | 0.459 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.253206 | 0.597 |
| R-HSA-205025 | NADE modulates death signalling | 0.088280 | 1.054 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.129464 | 0.888 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.155886 | 0.807 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.155886 | 0.807 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.206356 | 0.685 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.298457 | 0.525 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.309194 | 0.510 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.130541 | 0.884 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.379908 | 0.420 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.270307 | 0.568 |
| R-HSA-69306 | DNA Replication | 0.270884 | 0.567 |
| R-HSA-73887 | Death Receptor Signaling | 0.128533 | 0.891 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.343580 | 0.464 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.078769 | 1.104 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.271865 | 0.566 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.163991 | 0.785 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.230623 | 0.637 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.389403 | 0.410 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.365715 | 0.437 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.121950 | 0.914 |
| R-HSA-983189 | Kinesins | 0.088808 | 1.052 |
| R-HSA-381042 | PERK regulates gene expression | 0.137395 | 0.862 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.054665 | 1.262 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.049601 | 1.305 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.349138 | 0.457 |
| R-HSA-69239 | Synthesis of DNA | 0.113307 | 0.946 |
| R-HSA-199991 | Membrane Trafficking | 0.056115 | 1.251 |
| R-HSA-844615 | The AIM2 inflammasome | 0.059752 | 1.224 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.102219 | 0.990 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.155886 | 0.807 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.181508 | 0.741 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.218497 | 0.661 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.253820 | 0.595 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.360474 | 0.443 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.241938 | 0.616 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.379908 | 0.420 |
| R-HSA-68882 | Mitotic Anaphase | 0.074688 | 1.127 |
| R-HSA-4839726 | Chromatin organization | 0.236398 | 0.626 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.075985 | 1.119 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.102105 | 0.991 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.142391 | 0.847 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.218497 | 0.661 |
| R-HSA-69275 | G2/M Transition | 0.099270 | 1.003 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.285677 | 0.544 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.102712 | 0.988 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.330180 | 0.481 |
| R-HSA-3371556 | Cellular response to heat stress | 0.344816 | 0.462 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.115946 | 0.936 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.142776 | 0.845 |
| R-HSA-111458 | Formation of apoptosome | 0.181508 | 0.741 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.218497 | 0.661 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.218497 | 0.661 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.218497 | 0.661 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.230453 | 0.637 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.253820 | 0.595 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.265238 | 0.576 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.265238 | 0.576 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.287554 | 0.541 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.319767 | 0.495 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.338007 | 0.471 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.088808 | 1.052 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.298457 | 0.525 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.169416 | 0.771 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.389403 | 0.410 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.228780 | 0.641 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.045115 | 1.346 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.051748 | 1.286 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.078440 | 1.105 |
| R-HSA-397014 | Muscle contraction | 0.287810 | 0.541 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.168795 | 0.773 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.181508 | 0.741 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.206356 | 0.685 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.253820 | 0.595 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.276481 | 0.558 |
| R-HSA-70370 | Galactose catabolism | 0.276481 | 0.558 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.389403 | 0.410 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.081469 | 1.089 |
| R-HSA-5688426 | Deubiquitination | 0.134824 | 0.870 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.379908 | 0.420 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.389403 | 0.410 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.349138 | 0.457 |
| R-HSA-9659379 | Sensory processing of sound | 0.387560 | 0.412 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.360474 | 0.443 |
| R-HSA-69206 | G1/S Transition | 0.365680 | 0.437 |
| R-HSA-9635465 | Suppression of apoptosis | 0.194028 | 0.712 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.253820 | 0.595 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.319767 | 0.495 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.258953 | 0.587 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.326819 | 0.486 |
| R-HSA-74160 | Gene expression (Transcription) | 0.130506 | 0.884 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.206356 | 0.685 |
| R-HSA-69190 | DNA strand elongation | 0.116903 | 0.932 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.276481 | 0.558 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.330180 | 0.481 |
| R-HSA-8848021 | Signaling by PTK6 | 0.097868 | 1.009 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.097868 | 1.009 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.199914 | 0.699 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.258953 | 0.587 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.325789 | 0.487 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.130541 | 0.884 |
| R-HSA-3214842 | HDMs demethylate histones | 0.379908 | 0.420 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.185863 | 0.731 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.194028 | 0.712 |
| R-HSA-8876725 | Protein methylation | 0.253820 | 0.595 |
| R-HSA-5635838 | Activation of SMO | 0.265238 | 0.576 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.219344 | 0.659 |
| R-HSA-180786 | Extension of Telomeres | 0.275983 | 0.559 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.349138 | 0.457 |
| R-HSA-73886 | Chromosome Maintenance | 0.344816 | 0.462 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.273834 | 0.563 |
| R-HSA-9842663 | Signaling by LTK | 0.218497 | 0.661 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.340433 | 0.468 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.247415 | 0.607 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.267506 | 0.573 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.049601 | 1.305 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.304303 | 0.517 |
| R-HSA-4086400 | PCP/CE pathway | 0.382128 | 0.418 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.343580 | 0.464 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.057456 | 1.241 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.379908 | 0.420 |
| R-HSA-373760 | L1CAM interactions | 0.323896 | 0.490 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.298457 | 0.525 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.350530 | 0.455 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.350530 | 0.455 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.134278 | 0.872 |
| R-HSA-2028269 | Signaling by Hippo | 0.045833 | 1.339 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.382128 | 0.418 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.258953 | 0.587 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.142636 | 0.846 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.379908 | 0.420 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.336451 | 0.473 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.265238 | 0.576 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.132199 | 0.879 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.309194 | 0.510 |
| R-HSA-75153 | Apoptotic execution phase | 0.051784 | 1.286 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.371205 | 0.430 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.277983 | 0.556 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.219182 | 0.659 |
| R-HSA-3322077 | Glycogen synthesis | 0.319767 | 0.495 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.370265 | 0.431 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.370265 | 0.431 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.277983 | 0.556 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.240940 | 0.618 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.353171 | 0.452 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.398753 | 0.399 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.398753 | 0.399 |
| R-HSA-8949613 | Cristae formation | 0.398753 | 0.399 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.398753 | 0.399 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.398753 | 0.399 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.398753 | 0.399 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.398814 | 0.399 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.402925 | 0.395 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.407961 | 0.389 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.407961 | 0.389 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.407961 | 0.389 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.407961 | 0.389 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.407961 | 0.389 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.407961 | 0.389 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.407961 | 0.389 |
| R-HSA-622312 | Inflammasomes | 0.407961 | 0.389 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.407961 | 0.389 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.414390 | 0.383 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.414390 | 0.383 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.417028 | 0.380 |
| R-HSA-72086 | mRNA Capping | 0.417028 | 0.380 |
| R-HSA-1500620 | Meiosis | 0.419687 | 0.377 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.425957 | 0.371 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.425957 | 0.371 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.425957 | 0.371 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.427415 | 0.369 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.434750 | 0.362 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.434750 | 0.362 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.434750 | 0.362 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.434750 | 0.362 |
| R-HSA-182971 | EGFR downregulation | 0.434750 | 0.362 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.440625 | 0.356 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.443409 | 0.353 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.443409 | 0.353 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.443572 | 0.353 |
| R-HSA-8953854 | Metabolism of RNA | 0.447610 | 0.349 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.451935 | 0.345 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.451935 | 0.345 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.451935 | 0.345 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.451935 | 0.345 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.451935 | 0.345 |
| R-HSA-6798695 | Neutrophil degranulation | 0.455804 | 0.341 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.460332 | 0.337 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.460332 | 0.337 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.460332 | 0.337 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.460332 | 0.337 |
| R-HSA-212436 | Generic Transcription Pathway | 0.465189 | 0.332 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.467405 | 0.330 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.468600 | 0.329 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.468600 | 0.329 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.468600 | 0.329 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.468600 | 0.329 |
| R-HSA-5205647 | Mitophagy | 0.468600 | 0.329 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.468600 | 0.329 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.468600 | 0.329 |
| R-HSA-9758941 | Gastrulation | 0.475257 | 0.323 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.476742 | 0.322 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.476742 | 0.322 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.476742 | 0.322 |
| R-HSA-169911 | Regulation of Apoptosis | 0.476742 | 0.322 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.476742 | 0.322 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.484760 | 0.314 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.484760 | 0.314 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.484760 | 0.314 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.484760 | 0.314 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.484760 | 0.314 |
| R-HSA-3371511 | HSF1 activation | 0.484760 | 0.314 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.484760 | 0.314 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.484760 | 0.314 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.491084 | 0.309 |
| R-HSA-4641258 | Degradation of DVL | 0.492656 | 0.307 |
| R-HSA-4641257 | Degradation of AXIN | 0.492656 | 0.307 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.492656 | 0.307 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.492656 | 0.307 |
| R-HSA-157579 | Telomere Maintenance | 0.495972 | 0.305 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.495972 | 0.305 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.495972 | 0.305 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.500431 | 0.301 |
| R-HSA-1566948 | Elastic fibre formation | 0.500431 | 0.301 |
| R-HSA-3214847 | HATs acetylate histones | 0.505659 | 0.296 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.505659 | 0.296 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.505659 | 0.296 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.508087 | 0.294 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.508087 | 0.294 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.508087 | 0.294 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.508087 | 0.294 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.508087 | 0.294 |
| R-HSA-69541 | Stabilization of p53 | 0.508087 | 0.294 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.510457 | 0.292 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.510457 | 0.292 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.514200 | 0.289 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.515626 | 0.288 |
| R-HSA-167169 | HIV Transcription Elongation | 0.515626 | 0.288 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.515626 | 0.288 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.515626 | 0.288 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.515626 | 0.288 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.515626 | 0.288 |
| R-HSA-8982491 | Glycogen metabolism | 0.515626 | 0.288 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.517449 | 0.286 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.523051 | 0.281 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.523051 | 0.281 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.523051 | 0.281 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.523051 | 0.281 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.523051 | 0.281 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.523051 | 0.281 |
| R-HSA-162906 | HIV Infection | 0.528606 | 0.277 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.529341 | 0.276 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.530362 | 0.275 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.530362 | 0.275 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.530362 | 0.275 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.530362 | 0.275 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.530362 | 0.275 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.530362 | 0.275 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.530362 | 0.275 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.531775 | 0.274 |
| R-HSA-2262752 | Cellular responses to stress | 0.536733 | 0.270 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.538598 | 0.269 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.538598 | 0.269 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.544651 | 0.264 |
| R-HSA-8854214 | TBC/RABGAPs | 0.544651 | 0.264 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.544651 | 0.264 |
| R-HSA-9907900 | Proteasome assembly | 0.551632 | 0.258 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.551632 | 0.258 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.551632 | 0.258 |
| R-HSA-69236 | G1 Phase | 0.551632 | 0.258 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.551632 | 0.258 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.552245 | 0.258 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.552245 | 0.258 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.552245 | 0.258 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.558506 | 0.253 |
| R-HSA-774815 | Nucleosome assembly | 0.558506 | 0.253 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.558506 | 0.253 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.558506 | 0.253 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.558506 | 0.253 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.558506 | 0.253 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.558506 | 0.253 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.558506 | 0.253 |
| R-HSA-9824272 | Somitogenesis | 0.558506 | 0.253 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.561185 | 0.251 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.561185 | 0.251 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.561185 | 0.251 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.565276 | 0.248 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.565276 | 0.248 |
| R-HSA-9675135 | Diseases of DNA repair | 0.565276 | 0.248 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.571942 | 0.243 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.575411 | 0.240 |
| R-HSA-5620924 | Intraflagellar transport | 0.578507 | 0.238 |
| R-HSA-70263 | Gluconeogenesis | 0.578507 | 0.238 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.584971 | 0.233 |
| R-HSA-73893 | DNA Damage Bypass | 0.584971 | 0.233 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.584971 | 0.233 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.584971 | 0.233 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.591336 | 0.228 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.591336 | 0.228 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.595663 | 0.225 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.595663 | 0.225 |
| R-HSA-912446 | Meiotic recombination | 0.597604 | 0.224 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.597604 | 0.224 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.599828 | 0.222 |
| R-HSA-72187 | mRNA 3'-end processing | 0.603777 | 0.219 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.603777 | 0.219 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.603777 | 0.219 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.603777 | 0.219 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.603777 | 0.219 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.603777 | 0.219 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.603777 | 0.219 |
| R-HSA-1221632 | Meiotic synapsis | 0.609855 | 0.215 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.609855 | 0.215 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.609855 | 0.215 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.615840 | 0.211 |
| R-HSA-418597 | G alpha (z) signalling events | 0.621734 | 0.206 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.621734 | 0.206 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.624142 | 0.205 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.627537 | 0.202 |
| R-HSA-177929 | Signaling by EGFR | 0.627537 | 0.202 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.627764 | 0.202 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.628081 | 0.202 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.633252 | 0.198 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.633252 | 0.198 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.635389 | 0.197 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.635865 | 0.197 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.635865 | 0.197 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.635865 | 0.197 |
| R-HSA-114608 | Platelet degranulation | 0.643521 | 0.191 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.644422 | 0.191 |
| R-HSA-191859 | snRNP Assembly | 0.644422 | 0.191 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.644422 | 0.191 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.649879 | 0.187 |
| R-HSA-351202 | Metabolism of polyamines | 0.649879 | 0.187 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.649879 | 0.187 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.649879 | 0.187 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.649879 | 0.187 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.649879 | 0.187 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.649879 | 0.187 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.649879 | 0.187 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.655252 | 0.184 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.655252 | 0.184 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.655252 | 0.184 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.655252 | 0.184 |
| R-HSA-1474165 | Reproduction | 0.658452 | 0.181 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.660544 | 0.180 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.660544 | 0.180 |
| R-HSA-9707616 | Heme signaling | 0.660544 | 0.180 |
| R-HSA-5576891 | Cardiac conduction | 0.662106 | 0.179 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.662820 | 0.179 |
| R-HSA-9909396 | Circadian clock | 0.665728 | 0.177 |
| R-HSA-6799198 | Complex I biogenesis | 0.665754 | 0.177 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.665754 | 0.177 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.665754 | 0.177 |
| R-HSA-373755 | Semaphorin interactions | 0.665754 | 0.177 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.680913 | 0.167 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.683375 | 0.165 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.683375 | 0.165 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.696939 | 0.157 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.696939 | 0.157 |
| R-HSA-9664407 | Parasite infection | 0.696939 | 0.157 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.700064 | 0.155 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.700064 | 0.155 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.700064 | 0.155 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.700064 | 0.155 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.700064 | 0.155 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.700254 | 0.155 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.706795 | 0.151 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.709206 | 0.149 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.709206 | 0.149 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.710021 | 0.149 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.718070 | 0.144 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.718070 | 0.144 |
| R-HSA-8951664 | Neddylation | 0.718697 | 0.143 |
| R-HSA-8852135 | Protein ubiquitination | 0.722401 | 0.141 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.722401 | 0.141 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.725708 | 0.139 |
| R-HSA-5689603 | UCH proteinases | 0.726665 | 0.139 |
| R-HSA-5619084 | ABC transporter disorders | 0.734999 | 0.134 |
| R-HSA-216083 | Integrin cell surface interactions | 0.734999 | 0.134 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.737738 | 0.132 |
| R-HSA-9609507 | Protein localization | 0.740674 | 0.130 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.743080 | 0.129 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.743080 | 0.129 |
| R-HSA-9833482 | PKR-mediated signaling | 0.743080 | 0.129 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.750916 | 0.124 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.750916 | 0.124 |
| R-HSA-162587 | HIV Life Cycle | 0.752142 | 0.124 |
| R-HSA-597592 | Post-translational protein modification | 0.753855 | 0.123 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.754744 | 0.122 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.754744 | 0.122 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.754940 | 0.122 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.758514 | 0.120 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.760455 | 0.119 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.762225 | 0.118 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.762225 | 0.118 |
| R-HSA-157118 | Signaling by NOTCH | 0.764897 | 0.116 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.765880 | 0.116 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.765880 | 0.116 |
| R-HSA-1280218 | Adaptive Immune System | 0.768062 | 0.115 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.769479 | 0.114 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.769479 | 0.114 |
| R-HSA-168249 | Innate Immune System | 0.770470 | 0.113 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.773023 | 0.112 |
| R-HSA-156902 | Peptide chain elongation | 0.776513 | 0.110 |
| R-HSA-9663891 | Selective autophagy | 0.776513 | 0.110 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.779949 | 0.108 |
| R-HSA-202424 | Downstream TCR signaling | 0.783332 | 0.106 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.786664 | 0.104 |
| R-HSA-391251 | Protein folding | 0.793175 | 0.101 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.793175 | 0.101 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.793175 | 0.101 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.793747 | 0.100 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.798491 | 0.098 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.802573 | 0.096 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.805610 | 0.094 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.805610 | 0.094 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.808600 | 0.092 |
| R-HSA-162582 | Signal Transduction | 0.810839 | 0.091 |
| R-HSA-2559583 | Cellular Senescence | 0.812151 | 0.090 |
| R-HSA-190236 | Signaling by FGFR | 0.814444 | 0.089 |
| R-HSA-70171 | Glycolysis | 0.820111 | 0.086 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.821408 | 0.085 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.822879 | 0.085 |
| R-HSA-1483255 | PI Metabolism | 0.825605 | 0.083 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.830932 | 0.080 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.830932 | 0.080 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.832101 | 0.080 |
| R-HSA-9833110 | RSV-host interactions | 0.833534 | 0.079 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.835068 | 0.078 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.837021 | 0.077 |
| R-HSA-211000 | Gene Silencing by RNA | 0.841104 | 0.075 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.843551 | 0.074 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.843551 | 0.074 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.843697 | 0.074 |
| R-HSA-9658195 | Leishmania infection | 0.843697 | 0.074 |
| R-HSA-202403 | TCR signaling | 0.848332 | 0.071 |
| R-HSA-6803157 | Antimicrobial peptides | 0.850667 | 0.070 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.851913 | 0.070 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.857171 | 0.067 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.857171 | 0.067 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.857461 | 0.067 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.861818 | 0.065 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.863947 | 0.064 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.863947 | 0.064 |
| R-HSA-70326 | Glucose metabolism | 0.868107 | 0.061 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.868107 | 0.061 |
| R-HSA-422475 | Axon guidance | 0.870538 | 0.060 |
| R-HSA-68875 | Mitotic Prophase | 0.874110 | 0.058 |
| R-HSA-109582 | Hemostasis | 0.875721 | 0.058 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.876050 | 0.057 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.876050 | 0.057 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.879107 | 0.056 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.879842 | 0.056 |
| R-HSA-9679506 | SARS-CoV Infections | 0.880734 | 0.055 |
| R-HSA-194138 | Signaling by VEGF | 0.885313 | 0.053 |
| R-HSA-9717189 | Sensory perception of taste | 0.897133 | 0.047 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.898720 | 0.046 |
| R-HSA-9675108 | Nervous system development | 0.904955 | 0.043 |
| R-HSA-8939211 | ESR-mediated signaling | 0.907085 | 0.042 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.907740 | 0.042 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.909164 | 0.041 |
| R-HSA-6807070 | PTEN Regulation | 0.910565 | 0.041 |
| R-HSA-1632852 | Macroautophagy | 0.913304 | 0.039 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.915960 | 0.038 |
| R-HSA-72766 | Translation | 0.917522 | 0.037 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.918534 | 0.037 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.925796 | 0.033 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.925796 | 0.033 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.926841 | 0.033 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.926942 | 0.033 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.928070 | 0.032 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.930275 | 0.031 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.931352 | 0.031 |
| R-HSA-9612973 | Autophagy | 0.932412 | 0.030 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.933457 | 0.030 |
| R-HSA-9711097 | Cellular response to starvation | 0.934485 | 0.029 |
| R-HSA-449147 | Signaling by Interleukins | 0.934821 | 0.029 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.937206 | 0.028 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.947322 | 0.024 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.948939 | 0.023 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.948939 | 0.023 |
| R-HSA-611105 | Respiratory electron transport | 0.952768 | 0.021 |
| R-HSA-168255 | Influenza Infection | 0.953499 | 0.021 |
| R-HSA-1483257 | Phospholipid metabolism | 0.955678 | 0.020 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.956311 | 0.019 |
| R-HSA-3781865 | Diseases of glycosylation | 0.956987 | 0.019 |
| R-HSA-195721 | Signaling by WNT | 0.957377 | 0.019 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.958308 | 0.018 |
| R-HSA-983712 | Ion channel transport | 0.960214 | 0.018 |
| R-HSA-168256 | Immune System | 0.964692 | 0.016 |
| R-HSA-428157 | Sphingolipid metabolism | 0.967010 | 0.015 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.967812 | 0.014 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.968024 | 0.014 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.968024 | 0.014 |
| R-HSA-9824446 | Viral Infection Pathways | 0.969158 | 0.014 |
| R-HSA-8957322 | Metabolism of steroids | 0.969709 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.972392 | 0.012 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.972649 | 0.012 |
| R-HSA-1266738 | Developmental Biology | 0.976077 | 0.011 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.979032 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.981207 | 0.008 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.982009 | 0.008 |
| R-HSA-5663205 | Infectious disease | 0.983721 | 0.007 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.984180 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 0.986140 | 0.006 |
| R-HSA-416476 | G alpha (q) signalling events | 0.987880 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 0.990248 | 0.004 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.991812 | 0.004 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.992549 | 0.003 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.992665 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.994983 | 0.002 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.995202 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.995817 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.996386 | 0.002 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.996443 | 0.002 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.996712 | 0.001 |
| R-HSA-913531 | Interferon Signaling | 0.998166 | 0.001 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.998260 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998421 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998459 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998745 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.999086 | 0.000 |
| R-HSA-1643685 | Disease | 0.999443 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999452 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999931 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999956 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999982 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999988 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.837 | 0.444 | 2 | 0.903 |
CK2A2 |
0.829 | 0.532 | 1 | 0.826 |
CK2A1 |
0.819 | 0.485 | 1 | 0.809 |
COT |
0.808 | 0.111 | 2 | 0.751 |
CAMK2G |
0.806 | 0.217 | 2 | 0.778 |
GRK1 |
0.806 | 0.206 | -2 | 0.807 |
MOS |
0.804 | 0.181 | 1 | 0.875 |
GRK6 |
0.803 | 0.269 | 1 | 0.755 |
CDC7 |
0.802 | 0.086 | 1 | 0.853 |
GRK7 |
0.798 | 0.257 | 1 | 0.689 |
CLK3 |
0.798 | 0.098 | 1 | 0.755 |
CAMK2B |
0.798 | 0.228 | 2 | 0.801 |
BMPR1B |
0.796 | 0.184 | 1 | 0.747 |
TGFBR1 |
0.796 | 0.211 | -2 | 0.859 |
DSTYK |
0.793 | 0.077 | 2 | 0.774 |
IKKB |
0.792 | 0.057 | -2 | 0.737 |
PRPK |
0.792 | 0.018 | -1 | 0.856 |
ALK2 |
0.791 | 0.256 | -2 | 0.869 |
ATM |
0.790 | 0.104 | 1 | 0.699 |
PLK3 |
0.789 | 0.196 | 2 | 0.727 |
IKKA |
0.788 | 0.116 | -2 | 0.732 |
GRK4 |
0.787 | 0.082 | -2 | 0.850 |
GRK5 |
0.787 | 0.062 | -3 | 0.857 |
BMPR1A |
0.786 | 0.184 | 1 | 0.740 |
PIM3 |
0.785 | 0.021 | -3 | 0.813 |
CAMK1B |
0.785 | -0.000 | -3 | 0.848 |
BMPR2 |
0.784 | -0.015 | -2 | 0.889 |
CAMK2A |
0.784 | 0.124 | 2 | 0.763 |
ACVR2B |
0.784 | 0.157 | -2 | 0.881 |
PDHK4 |
0.784 | -0.070 | 1 | 0.762 |
ACVR2A |
0.783 | 0.148 | -2 | 0.876 |
PLK1 |
0.783 | 0.125 | -2 | 0.854 |
ALK4 |
0.783 | 0.115 | -2 | 0.878 |
RAF1 |
0.782 | -0.105 | 1 | 0.736 |
ATR |
0.782 | -0.006 | 1 | 0.747 |
NDR2 |
0.781 | -0.005 | -3 | 0.812 |
MTOR |
0.780 | -0.108 | 1 | 0.701 |
KIS |
0.780 | 0.026 | 1 | 0.631 |
GCN2 |
0.780 | -0.150 | 2 | 0.670 |
RSK2 |
0.780 | 0.033 | -3 | 0.747 |
TBK1 |
0.779 | -0.084 | 1 | 0.626 |
MAPKAPK2 |
0.779 | 0.093 | -3 | 0.696 |
SKMLCK |
0.778 | 0.023 | -2 | 0.834 |
IKKE |
0.777 | -0.074 | 1 | 0.616 |
LATS1 |
0.777 | 0.132 | -3 | 0.826 |
NEK6 |
0.776 | -0.078 | -2 | 0.881 |
CAMK2D |
0.776 | 0.050 | -3 | 0.821 |
PIM1 |
0.776 | 0.039 | -3 | 0.756 |
CAMLCK |
0.775 | -0.024 | -2 | 0.829 |
PKN3 |
0.774 | -0.036 | -3 | 0.805 |
GSK3A |
0.774 | 0.044 | 4 | 0.372 |
PLK2 |
0.773 | 0.149 | -3 | 0.802 |
NEK7 |
0.773 | -0.124 | -3 | 0.851 |
PDHK1 |
0.773 | -0.142 | 1 | 0.734 |
ERK5 |
0.773 | -0.055 | 1 | 0.702 |
CDKL1 |
0.773 | -0.046 | -3 | 0.783 |
TGFBR2 |
0.773 | -0.060 | -2 | 0.882 |
NLK |
0.772 | -0.109 | 1 | 0.740 |
HUNK |
0.772 | -0.089 | 2 | 0.683 |
LATS2 |
0.772 | 0.019 | -5 | 0.736 |
DNAPK |
0.771 | 0.087 | 1 | 0.624 |
CLK2 |
0.771 | 0.074 | -3 | 0.729 |
ULK2 |
0.771 | -0.189 | 2 | 0.657 |
DAPK2 |
0.771 | -0.055 | -3 | 0.852 |
SRPK1 |
0.770 | -0.012 | -3 | 0.729 |
JNK3 |
0.768 | 0.049 | 1 | 0.603 |
NIK |
0.768 | -0.148 | -3 | 0.867 |
PRKD1 |
0.768 | -0.039 | -3 | 0.790 |
TTBK2 |
0.767 | -0.078 | 2 | 0.598 |
MLK1 |
0.767 | -0.154 | 2 | 0.663 |
P90RSK |
0.767 | -0.025 | -3 | 0.750 |
BCKDK |
0.767 | -0.095 | -1 | 0.801 |
P70S6KB |
0.767 | -0.026 | -3 | 0.773 |
GSK3B |
0.767 | -0.007 | 4 | 0.357 |
RIPK3 |
0.766 | -0.187 | 3 | 0.510 |
ULK1 |
0.766 | -0.138 | -3 | 0.821 |
RSK4 |
0.766 | 0.037 | -3 | 0.712 |
GRK2 |
0.765 | 0.013 | -2 | 0.739 |
MARK4 |
0.765 | -0.094 | 4 | 0.478 |
TSSK2 |
0.765 | -0.044 | -5 | 0.815 |
WNK1 |
0.765 | -0.124 | -2 | 0.824 |
CHAK2 |
0.765 | -0.121 | -1 | 0.830 |
MSK1 |
0.765 | 0.032 | -3 | 0.715 |
DLK |
0.764 | -0.124 | 1 | 0.716 |
JNK2 |
0.764 | 0.042 | 1 | 0.566 |
NDR1 |
0.764 | -0.088 | -3 | 0.805 |
NUAK2 |
0.762 | -0.108 | -3 | 0.820 |
MAPKAPK3 |
0.762 | -0.025 | -3 | 0.744 |
MST4 |
0.762 | -0.124 | 2 | 0.697 |
ICK |
0.762 | -0.060 | -3 | 0.816 |
MSK2 |
0.762 | -0.009 | -3 | 0.714 |
PKACG |
0.762 | -0.031 | -2 | 0.731 |
PRKX |
0.762 | 0.059 | -3 | 0.646 |
SRPK2 |
0.762 | -0.014 | -3 | 0.650 |
PRKD2 |
0.762 | -0.037 | -3 | 0.744 |
SRPK3 |
0.762 | -0.026 | -3 | 0.705 |
CDKL5 |
0.761 | -0.068 | -3 | 0.770 |
HIPK4 |
0.761 | -0.073 | 1 | 0.703 |
MASTL |
0.761 | -0.213 | -2 | 0.782 |
AURA |
0.761 | 0.016 | -2 | 0.628 |
RSK3 |
0.761 | -0.054 | -3 | 0.743 |
PAK1 |
0.761 | -0.023 | -2 | 0.750 |
AMPKA1 |
0.760 | -0.101 | -3 | 0.828 |
TLK2 |
0.760 | -0.027 | 1 | 0.665 |
CDK8 |
0.760 | -0.026 | 1 | 0.592 |
MEK1 |
0.760 | -0.082 | 2 | 0.714 |
GRK3 |
0.760 | 0.040 | -2 | 0.707 |
ANKRD3 |
0.760 | -0.206 | 1 | 0.738 |
CDK1 |
0.759 | -0.011 | 1 | 0.581 |
CLK4 |
0.759 | -0.003 | -3 | 0.744 |
DYRK2 |
0.758 | -0.015 | 1 | 0.632 |
PKN2 |
0.758 | -0.131 | -3 | 0.812 |
PKR |
0.758 | -0.099 | 1 | 0.740 |
WNK3 |
0.758 | -0.235 | 1 | 0.701 |
PKCD |
0.757 | -0.103 | 2 | 0.640 |
RIPK1 |
0.757 | -0.200 | 1 | 0.711 |
PASK |
0.756 | 0.028 | -3 | 0.830 |
PKACB |
0.756 | 0.019 | -2 | 0.674 |
MLK3 |
0.756 | -0.127 | 2 | 0.597 |
CAMK4 |
0.756 | -0.087 | -3 | 0.795 |
NEK9 |
0.755 | -0.212 | 2 | 0.675 |
TSSK1 |
0.755 | -0.092 | -3 | 0.848 |
JNK1 |
0.755 | 0.039 | 1 | 0.567 |
AURC |
0.755 | -0.029 | -2 | 0.660 |
SMG1 |
0.754 | -0.047 | 1 | 0.703 |
MYLK4 |
0.754 | -0.037 | -2 | 0.757 |
TLK1 |
0.754 | -0.053 | -2 | 0.882 |
DYRK4 |
0.753 | 0.024 | 1 | 0.574 |
DRAK1 |
0.753 | -0.065 | 1 | 0.698 |
BRAF |
0.753 | -0.034 | -4 | 0.819 |
NIM1 |
0.752 | -0.142 | 3 | 0.556 |
MLK4 |
0.752 | -0.123 | 2 | 0.583 |
AMPKA2 |
0.751 | -0.106 | -3 | 0.791 |
VRK2 |
0.751 | -0.298 | 1 | 0.768 |
CLK1 |
0.751 | -0.022 | -3 | 0.723 |
CDK19 |
0.751 | -0.035 | 1 | 0.558 |
BRSK1 |
0.750 | -0.075 | -3 | 0.769 |
P38B |
0.750 | -0.003 | 1 | 0.570 |
PAK2 |
0.750 | -0.071 | -2 | 0.736 |
PAK3 |
0.750 | -0.100 | -2 | 0.744 |
CK1E |
0.749 | -0.024 | -3 | 0.558 |
MEKK3 |
0.749 | -0.117 | 1 | 0.681 |
YSK4 |
0.749 | -0.157 | 1 | 0.658 |
AURB |
0.748 | -0.038 | -2 | 0.652 |
CDK3 |
0.748 | -0.005 | 1 | 0.529 |
MARK2 |
0.748 | -0.091 | 4 | 0.400 |
CDK2 |
0.748 | -0.061 | 1 | 0.643 |
P38G |
0.748 | -0.004 | 1 | 0.501 |
P38A |
0.747 | -0.037 | 1 | 0.624 |
CDK13 |
0.747 | -0.049 | 1 | 0.596 |
PERK |
0.747 | -0.130 | -2 | 0.887 |
PLK4 |
0.747 | -0.114 | 2 | 0.559 |
MARK3 |
0.746 | -0.096 | 4 | 0.421 |
CDK7 |
0.746 | -0.067 | 1 | 0.617 |
PAK6 |
0.746 | -0.045 | -2 | 0.679 |
CHK1 |
0.746 | -0.055 | -3 | 0.790 |
MLK2 |
0.746 | -0.265 | 2 | 0.662 |
PRKD3 |
0.746 | -0.075 | -3 | 0.722 |
IRE1 |
0.746 | -0.237 | 1 | 0.687 |
CDK5 |
0.746 | -0.058 | 1 | 0.627 |
PRP4 |
0.746 | -0.024 | -3 | 0.765 |
MNK2 |
0.745 | -0.091 | -2 | 0.759 |
IRE2 |
0.745 | -0.187 | 2 | 0.619 |
P38D |
0.745 | 0.010 | 1 | 0.527 |
CAMK1G |
0.745 | -0.076 | -3 | 0.743 |
CK1D |
0.745 | -0.009 | -3 | 0.509 |
HRI |
0.744 | -0.173 | -2 | 0.887 |
HIPK2 |
0.744 | -0.016 | 1 | 0.562 |
MNK1 |
0.744 | -0.081 | -2 | 0.776 |
QSK |
0.744 | -0.123 | 4 | 0.449 |
PIM2 |
0.744 | -0.034 | -3 | 0.721 |
PKCG |
0.743 | -0.136 | 2 | 0.592 |
NEK2 |
0.743 | -0.158 | 2 | 0.649 |
SGK3 |
0.743 | -0.041 | -3 | 0.729 |
ERK1 |
0.743 | -0.037 | 1 | 0.560 |
ERK2 |
0.743 | -0.054 | 1 | 0.607 |
AKT2 |
0.743 | -0.044 | -3 | 0.666 |
MAPKAPK5 |
0.742 | -0.091 | -3 | 0.690 |
PKG2 |
0.742 | -0.054 | -2 | 0.676 |
GAK |
0.742 | -0.021 | 1 | 0.746 |
PKCB |
0.742 | -0.127 | 2 | 0.578 |
MARK1 |
0.742 | -0.105 | 4 | 0.436 |
DYRK1A |
0.742 | -0.038 | 1 | 0.669 |
HIPK1 |
0.742 | -0.036 | 1 | 0.646 |
DCAMKL1 |
0.742 | -0.074 | -3 | 0.760 |
PKACA |
0.742 | 0.008 | -2 | 0.632 |
NUAK1 |
0.741 | -0.139 | -3 | 0.767 |
TTBK1 |
0.741 | -0.104 | 2 | 0.543 |
PKCA |
0.741 | -0.132 | 2 | 0.577 |
CAMK1D |
0.741 | -0.003 | -3 | 0.666 |
MELK |
0.741 | -0.150 | -3 | 0.776 |
SMMLCK |
0.740 | -0.073 | -3 | 0.797 |
PKCH |
0.740 | -0.148 | 2 | 0.576 |
CHAK1 |
0.739 | -0.239 | 2 | 0.615 |
CDK12 |
0.739 | -0.050 | 1 | 0.570 |
PDHK3_TYR |
0.739 | 0.281 | 4 | 0.597 |
DYRK1B |
0.739 | -0.013 | 1 | 0.596 |
QIK |
0.739 | -0.207 | -3 | 0.818 |
PINK1 |
0.739 | -0.173 | 1 | 0.728 |
SIK |
0.739 | -0.124 | -3 | 0.739 |
DCAMKL2 |
0.739 | -0.078 | -3 | 0.788 |
DAPK3 |
0.739 | -0.011 | -3 | 0.778 |
CK1A2 |
0.738 | -0.031 | -3 | 0.508 |
MEKK2 |
0.738 | -0.195 | 2 | 0.658 |
DAPK1 |
0.738 | -0.003 | -3 | 0.759 |
CDK18 |
0.738 | -0.062 | 1 | 0.555 |
MEK5 |
0.737 | -0.304 | 2 | 0.682 |
CAMKK1 |
0.737 | -0.097 | -2 | 0.741 |
CDK9 |
0.736 | -0.066 | 1 | 0.600 |
SSTK |
0.736 | -0.094 | 4 | 0.432 |
BRSK2 |
0.736 | -0.162 | -3 | 0.794 |
SNRK |
0.736 | -0.217 | 2 | 0.589 |
CDK17 |
0.735 | -0.057 | 1 | 0.510 |
MEKK1 |
0.735 | -0.228 | 1 | 0.686 |
NEK5 |
0.735 | -0.209 | 1 | 0.709 |
ALPHAK3 |
0.735 | 0.093 | -1 | 0.810 |
PKCZ |
0.735 | -0.174 | 2 | 0.623 |
DYRK3 |
0.734 | -0.031 | 1 | 0.647 |
ZAK |
0.734 | -0.220 | 1 | 0.656 |
TAO3 |
0.734 | -0.148 | 1 | 0.684 |
CK1G1 |
0.733 | -0.076 | -3 | 0.561 |
P70S6K |
0.733 | -0.066 | -3 | 0.678 |
WNK4 |
0.733 | -0.195 | -2 | 0.809 |
PDHK4_TYR |
0.731 | 0.168 | 2 | 0.769 |
EEF2K |
0.731 | -0.118 | 3 | 0.602 |
MAP2K6_TYR |
0.731 | 0.159 | -1 | 0.884 |
PHKG1 |
0.731 | -0.205 | -3 | 0.800 |
CAMKK2 |
0.731 | -0.126 | -2 | 0.736 |
PDHK1_TYR |
0.731 | 0.155 | -1 | 0.912 |
NEK8 |
0.731 | -0.213 | 2 | 0.666 |
HIPK3 |
0.730 | -0.080 | 1 | 0.635 |
MPSK1 |
0.730 | -0.114 | 1 | 0.677 |
MST3 |
0.728 | -0.198 | 2 | 0.665 |
AKT1 |
0.728 | -0.056 | -3 | 0.679 |
LKB1 |
0.728 | -0.139 | -3 | 0.835 |
CDK16 |
0.728 | -0.053 | 1 | 0.529 |
ERK7 |
0.727 | -0.058 | 2 | 0.426 |
CDK14 |
0.727 | -0.081 | 1 | 0.590 |
SGK1 |
0.727 | -0.003 | -3 | 0.577 |
MAP2K4_TYR |
0.727 | 0.068 | -1 | 0.881 |
BMPR2_TYR |
0.727 | 0.066 | -1 | 0.893 |
PDK1 |
0.726 | -0.142 | 1 | 0.709 |
IRAK4 |
0.726 | -0.253 | 1 | 0.688 |
IRAK1 |
0.726 | -0.235 | -1 | 0.749 |
TAO2 |
0.725 | -0.196 | 2 | 0.698 |
TAK1 |
0.725 | -0.134 | 1 | 0.692 |
NEK11 |
0.725 | -0.259 | 1 | 0.677 |
PAK4 |
0.724 | -0.064 | -2 | 0.625 |
MST2 |
0.724 | -0.161 | 1 | 0.681 |
YANK3 |
0.723 | -0.040 | 2 | 0.395 |
PAK5 |
0.723 | -0.075 | -2 | 0.618 |
GCK |
0.723 | -0.155 | 1 | 0.668 |
EPHA4 |
0.722 | 0.094 | 2 | 0.734 |
PKCT |
0.722 | -0.163 | 2 | 0.581 |
CDK10 |
0.721 | -0.069 | 1 | 0.581 |
TESK1_TYR |
0.721 | -0.076 | 3 | 0.641 |
EPHA6 |
0.721 | 0.010 | -1 | 0.913 |
SBK |
0.721 | 0.005 | -3 | 0.546 |
TNIK |
0.720 | -0.155 | 3 | 0.591 |
MAP2K7_TYR |
0.719 | -0.067 | 2 | 0.748 |
VRK1 |
0.719 | -0.234 | 2 | 0.703 |
LRRK2 |
0.719 | -0.230 | 2 | 0.706 |
PHKG2 |
0.719 | -0.181 | -3 | 0.775 |
STK33 |
0.719 | -0.146 | 2 | 0.543 |
MAK |
0.717 | -0.021 | -2 | 0.701 |
NEK4 |
0.717 | -0.249 | 1 | 0.666 |
PKCE |
0.717 | -0.121 | 2 | 0.575 |
CAMK1A |
0.717 | -0.058 | -3 | 0.628 |
MINK |
0.717 | -0.201 | 1 | 0.657 |
MRCKA |
0.717 | -0.057 | -3 | 0.727 |
PKCI |
0.716 | -0.166 | 2 | 0.594 |
AKT3 |
0.716 | -0.047 | -3 | 0.596 |
TTK |
0.716 | -0.085 | -2 | 0.882 |
PINK1_TYR |
0.716 | -0.119 | 1 | 0.757 |
MEK2 |
0.715 | -0.203 | 2 | 0.673 |
MST1 |
0.715 | -0.178 | 1 | 0.662 |
EPHB4 |
0.715 | -0.019 | -1 | 0.883 |
TXK |
0.715 | 0.050 | 1 | 0.789 |
CDK6 |
0.714 | -0.080 | 1 | 0.572 |
SRMS |
0.714 | 0.058 | 1 | 0.763 |
MRCKB |
0.714 | -0.059 | -3 | 0.711 |
FER |
0.714 | 0.040 | 1 | 0.783 |
HGK |
0.714 | -0.218 | 3 | 0.578 |
CDK4 |
0.714 | -0.067 | 1 | 0.560 |
ROCK2 |
0.713 | -0.057 | -3 | 0.753 |
NEK1 |
0.713 | -0.237 | 1 | 0.685 |
HPK1 |
0.712 | -0.184 | 1 | 0.659 |
INSRR |
0.712 | 0.007 | 3 | 0.509 |
MAP3K15 |
0.712 | -0.265 | 1 | 0.644 |
PKMYT1_TYR |
0.712 | -0.195 | 3 | 0.602 |
CHK2 |
0.711 | -0.089 | -3 | 0.608 |
RIPK2 |
0.711 | -0.242 | 1 | 0.631 |
MOK |
0.711 | -0.050 | 1 | 0.652 |
EPHB2 |
0.710 | 0.024 | -1 | 0.875 |
YES1 |
0.710 | -0.028 | -1 | 0.858 |
DMPK1 |
0.709 | -0.038 | -3 | 0.738 |
PKN1 |
0.709 | -0.125 | -3 | 0.698 |
BUB1 |
0.709 | -0.090 | -5 | 0.759 |
PBK |
0.708 | -0.100 | 1 | 0.672 |
CK1A |
0.708 | -0.035 | -3 | 0.423 |
SLK |
0.708 | -0.158 | -2 | 0.703 |
LOK |
0.707 | -0.206 | -2 | 0.743 |
BIKE |
0.707 | -0.036 | 1 | 0.639 |
FYN |
0.707 | 0.039 | -1 | 0.839 |
EPHB1 |
0.707 | -0.036 | 1 | 0.741 |
MEKK6 |
0.707 | -0.318 | 1 | 0.653 |
DDR1 |
0.707 | -0.101 | 4 | 0.513 |
KHS2 |
0.706 | -0.150 | 1 | 0.660 |
BLK |
0.706 | -0.004 | -1 | 0.874 |
EPHB3 |
0.706 | -0.010 | -1 | 0.869 |
KHS1 |
0.706 | -0.176 | 1 | 0.651 |
OSR1 |
0.706 | -0.146 | 2 | 0.641 |
RET |
0.706 | -0.159 | 1 | 0.686 |
EPHA5 |
0.706 | 0.057 | 2 | 0.734 |
FGFR2 |
0.705 | -0.055 | 3 | 0.555 |
LIMK2_TYR |
0.705 | -0.171 | -3 | 0.875 |
CRIK |
0.704 | -0.029 | -3 | 0.675 |
ABL2 |
0.704 | -0.083 | -1 | 0.851 |
HASPIN |
0.704 | -0.085 | -1 | 0.673 |
HCK |
0.704 | -0.069 | -1 | 0.859 |
PTK2 |
0.703 | 0.062 | -1 | 0.846 |
EPHA3 |
0.703 | -0.024 | 2 | 0.704 |
FGR |
0.703 | -0.107 | 1 | 0.734 |
EPHA7 |
0.702 | -0.018 | 2 | 0.722 |
LCK |
0.701 | -0.059 | -1 | 0.866 |
YSK1 |
0.701 | -0.242 | 2 | 0.641 |
EGFR |
0.701 | 0.038 | 1 | 0.577 |
LIMK1_TYR |
0.700 | -0.255 | 2 | 0.725 |
SYK |
0.700 | 0.076 | -1 | 0.842 |
MERTK |
0.700 | -0.047 | 3 | 0.526 |
TYK2 |
0.699 | -0.230 | 1 | 0.679 |
CSF1R |
0.699 | -0.167 | 3 | 0.510 |
JAK3 |
0.699 | -0.142 | 1 | 0.683 |
MST1R |
0.699 | -0.251 | 3 | 0.534 |
TYRO3 |
0.699 | -0.213 | 3 | 0.523 |
JAK2 |
0.698 | -0.208 | 1 | 0.673 |
FGFR3 |
0.698 | -0.049 | 3 | 0.537 |
ROCK1 |
0.698 | -0.072 | -3 | 0.721 |
ASK1 |
0.698 | -0.192 | 1 | 0.643 |
PKG1 |
0.697 | -0.085 | -2 | 0.597 |
ABL1 |
0.697 | -0.131 | -1 | 0.844 |
ITK |
0.697 | -0.098 | -1 | 0.825 |
KIT |
0.697 | -0.119 | 3 | 0.518 |
BMX |
0.697 | -0.050 | -1 | 0.757 |
ROS1 |
0.696 | -0.236 | 3 | 0.498 |
FLT1 |
0.696 | -0.065 | -1 | 0.897 |
NTRK1 |
0.696 | -0.059 | -1 | 0.844 |
EPHA8 |
0.696 | -0.017 | -1 | 0.864 |
TNK2 |
0.695 | -0.142 | 3 | 0.502 |
ERBB2 |
0.694 | -0.099 | 1 | 0.656 |
CK1G3 |
0.694 | -0.025 | -3 | 0.379 |
TEC |
0.694 | -0.092 | -1 | 0.770 |
LYN |
0.693 | -0.063 | 3 | 0.471 |
FGFR4 |
0.693 | 0.003 | -1 | 0.829 |
PTK2B |
0.693 | -0.043 | -1 | 0.804 |
TEK |
0.693 | -0.155 | 3 | 0.489 |
FGFR1 |
0.693 | -0.150 | 3 | 0.520 |
NEK3 |
0.692 | -0.281 | 1 | 0.636 |
FLT3 |
0.692 | -0.167 | 3 | 0.512 |
AXL |
0.692 | -0.126 | 3 | 0.518 |
KDR |
0.692 | -0.175 | 3 | 0.497 |
SRC |
0.691 | -0.042 | -1 | 0.840 |
LTK |
0.691 | -0.119 | 3 | 0.487 |
MET |
0.691 | -0.142 | 3 | 0.512 |
PDGFRB |
0.690 | -0.203 | 3 | 0.523 |
MYO3B |
0.690 | -0.216 | 2 | 0.659 |
EPHA2 |
0.690 | 0.002 | -1 | 0.846 |
MYO3A |
0.690 | -0.220 | 1 | 0.666 |
BTK |
0.689 | -0.162 | -1 | 0.785 |
FLT4 |
0.689 | -0.131 | 3 | 0.515 |
INSR |
0.689 | -0.105 | 3 | 0.487 |
IGF1R |
0.689 | -0.016 | 3 | 0.453 |
FRK |
0.688 | -0.129 | -1 | 0.884 |
PTK6 |
0.688 | -0.148 | -1 | 0.754 |
DDR2 |
0.688 | -0.055 | 3 | 0.496 |
AAK1 |
0.687 | -0.022 | 1 | 0.543 |
ERBB4 |
0.687 | -0.007 | 1 | 0.607 |
ALK |
0.687 | -0.158 | 3 | 0.462 |
YANK2 |
0.687 | -0.069 | 2 | 0.414 |
CSK |
0.687 | -0.062 | 2 | 0.713 |
STLK3 |
0.686 | -0.187 | 1 | 0.625 |
TAO1 |
0.686 | -0.221 | 1 | 0.611 |
NTRK3 |
0.686 | -0.079 | -1 | 0.800 |
NEK10_TYR |
0.685 | -0.162 | 1 | 0.588 |
CK1G2 |
0.685 | -0.025 | -3 | 0.476 |
EPHA1 |
0.684 | -0.154 | 3 | 0.486 |
MATK |
0.684 | -0.084 | -1 | 0.787 |
NTRK2 |
0.684 | -0.168 | 3 | 0.504 |
WEE1_TYR |
0.683 | -0.156 | -1 | 0.756 |
JAK1 |
0.680 | -0.206 | 1 | 0.625 |
TNK1 |
0.679 | -0.227 | 3 | 0.512 |
PDGFRA |
0.679 | -0.284 | 3 | 0.518 |
TNNI3K_TYR |
0.674 | -0.229 | 1 | 0.685 |
FES |
0.666 | -0.100 | -1 | 0.740 |
MUSK |
0.659 | -0.191 | 1 | 0.562 |
ZAP70 |
0.657 | -0.050 | -1 | 0.745 |