Motif 544 (n=142)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | Y453 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| E9PCH4 | None | S706 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H7C1W4 | None | S396 | ochoa | Uncharacterized protein | None |
| O00559 | EBAG9 | S86 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14513 | NCKAP5 | S630 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14974 | PPP1R12A | S422 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15085 | ARHGEF11 | S1155 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15397 | IPO8 | S595 | ochoa | Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) | Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382, ECO:0000305|PubMed:34010604}. |
| O15440 | ABCC5 | S558 | ochoa | ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). {ECO:0000250|UniProtKB:Q9R1X5, ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:10893247, ECO:0000269|PubMed:12435799, ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538, ECO:0000269|PubMed:15899835, ECO:0000269|PubMed:17229149, ECO:0000269|PubMed:24836561, ECO:0000269|PubMed:25964343, ECO:0000269|PubMed:26515061}. |
| O43159 | RRP8 | S64 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O60281 | ZNF292 | S1483 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60826 | CCDC22 | S347 | ochoa | Coiled-coil domain-containing protein 22 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). Involved in regulation of NF-kappa-B signaling (PubMed:23563313). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (PubMed:23563313). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Plays a role in copper ion homeostasis (PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| O75152 | ZC3H11A | S171 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O94769 | ECM2 | S213 | ochoa | Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2) | Promotes matrix assembly and cell adhesiveness. {ECO:0000250|UniProtKB:Q5FW85}. |
| O94885 | SASH1 | S374 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94966 | USP19 | S480 | ochoa | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816). {ECO:0000250|UniProtKB:Q3UJD6, ECO:0000250|UniProtKB:Q6J1Y9, ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:24356957, ECO:0000269|PubMed:31127032, ECO:0000269|PubMed:33094816, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:38943386}. |
| O94967 | WDR47 | S396 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95425 | SVIL | S56 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95696 | BRD1 | S808 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95772 | STARD3NL | S39 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P00749 | PLAU | S158 | psp | Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] | Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. |
| P01100 | FOS | S133 | ochoa | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
| P01270 | PTH | S48 | psp | Parathyroid hormone (PTH) (Parathormone) (Parathyrin) | Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed:11604398, PubMed:35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:18375760, PubMed:35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed:21076856). {ECO:0000269|PubMed:11604398, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:35932760}. |
| P01833 | PIGR | S735 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
| P02545 | LMNA | S212 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S533 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05060 | CHGB | S263 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06239 | LCK | S121 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P07237 | P4HB | S357 | psp | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07437 | TUBB | Y106 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0C671 | BNIP5 | S344 | ochoa | Protein BNIP5 | None |
| P11055 | MYH3 | T1384 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | T1387 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1383 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13010 | XRCC5 | S695 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13533 | MYH6 | T1385 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T1386 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14625 | HSP90B1 | S347 | psp | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15407 | FOSL1 | S101 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15408 | FOSL2 | S120 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P18583 | SON | S55 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P23528 | CFL1 | S24 | ochoa|psp | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}. |
| P28290 | ITPRID2 | S466 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P30291 | WEE1 | S444 | psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30622 | CLIP1 | S48 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P30876 | POLR2B | S75 | ochoa | DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:27193682, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). {ECO:0000250|UniProtKB:A5PJW8, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}. |
| P31943 | HNRNPH1 | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P33992 | MCM5 | S315 | ochoa | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| P34931 | HSPA1L | S241 | psp | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P38398 | BRCA1 | S434 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42858 | HTT | S2340 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46939 | UTRN | S3254 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49069 | CAMLG | S55 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P49327 | FASN | S286 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49768 | PSEN1 | S337 | ochoa | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P49810 | PSEN2 | S49 | ochoa | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
| P52597 | HNRNPF | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P54578 | USP14 | S260 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55795 | HNRNPH2 | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P60981 | DSTN | S24 | ochoa | Destrin (Actin-depolymerizing factor) (ADF) | Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}. |
| P68371 | TUBB4B | Y106 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78559 | MAP1A | S667 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02487 | DSC2 | S873 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02952 | AKAP12 | S96 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03468 | ERCC6 | S1189 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q08945 | SSRP1 | S405 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q12774 | ARHGEF5 | S468 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | S398 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1759 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12931 | TRAP1 | S511 | psp | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13029 | PRDM2 | S1256 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13370 | PDE3B | S602 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13422 | IKZF1 | S298 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13509 | TUBB3 | Y106 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | Y106 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14126 | DSG2 | Y783 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14207 | NPAT | S371 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14789 | GOLGB1 | S139 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14978 | NOLC1 | S563 | ochoa|psp | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14980 | NUMA1 | S1228 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15032 | R3HDM1 | S111 | ochoa | R3H domain-containing protein 1 | None |
| Q15059 | BRD3 | S563 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q53T59 | HS1BP3 | S194 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5VZ89 | DENND4C | S1802 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6P0N0 | MIS18BP1 | S776 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q7RTP6 | MICAL3 | S1321 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z478 | DHX29 | S251 | ochoa | ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) | ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000255|HAMAP-Rule:MF_03068, ECO:0000269|PubMed:19109895, ECO:0000269|PubMed:23706745}. |
| Q7Z7F0 | KHDC4 | S572 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q86TB3 | ALPK2 | S1373 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
| Q8N344 | MIER2 | S132 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N543 | OGFOD1 | S371 | ochoa | Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase) | Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. {ECO:0000269|PubMed:20154146, ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}. |
| Q8N556 | AFAP1 | Y125 | psp | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8NC44 | RETREG2 | S385 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8TC05 | MDM1 | S407 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TEK3 | DOT1L | S374 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEU7 | RAPGEF6 | S656 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WXF7 | ATL1 | S22 | ochoa|psp | Atlastin-1 (ATL-1) (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A) | Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:14506257, PubMed:18270207, PubMed:19665976, PubMed:27619977, PubMed:34817557, PubMed:38509071). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (PubMed:14506257, PubMed:21220294, PubMed:21368113, PubMed:23334294, PubMed:38509071). May also regulate more or less directly Golgi biogenesis (PubMed:17321752). Indirectly regulates axonal development (By similarity). {ECO:0000250|UniProtKB:Q6PST4, ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:21368113, ECO:0000269|PubMed:23334294, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557, ECO:0000269|PubMed:38509071}. |
| Q92576 | PHF3 | S869 | ochoa | PHD finger protein 3 | None |
| Q92667 | AKAP1 | S238 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q93075 | TATDN2 | S453 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q969E3 | UCN3 | S69 | ochoa | Urocortin-3 (Stresscopin) (Urocortin III) (Ucn III) | Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. |
| Q96AE4 | FUBP1 | S99 | ochoa|psp | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96IZ7 | RSRC1 | S254 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96NB3 | ZNF830 | S225 | ochoa | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}. |
| Q96Q89 | KIF20B | S1658 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q99661 | KIF2C | S621 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q9BV36 | MLPH | S403 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BVA1 | TUBB2B | Y106 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BW71 | HIRIP3 | S159 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BWK5 | CYREN | S138 | ochoa | Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog) | Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (PubMed:28959974). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000269|PubMed:24610814, ECO:0000269|PubMed:28959974}. |
| Q9BX63 | BRIP1 | S226 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BYT3 | STK33 | S441 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9BZ95 | NSD3 | S457 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZL6 | PRKD2 | S362 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9GZR7 | DDX24 | S82 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9NQT8 | KIF13B | S858 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NSI6 | BRWD1 | S2118 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NXE8 | CWC25 | S337 | ochoa | Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) | Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000269|PubMed:29301961}. |
| Q9UBE0 | SAE1 | S201 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UHD8 | SEPTIN9 | S30 | ochoa|psp | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UKX2 | MYH2 | Y1353 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1389 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T1387 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UPP1 | PHF8 | S826 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPQ9 | TNRC6B | S1011 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9Y281 | CFL2 | S24 | ochoa | Cofilin-2 (Cofilin, muscle isoform) | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}. |
| Q9Y4W2 | LAS1L | S246 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5K6 | CD2AP | S233 | ochoa|psp | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y623 | MYH4 | T1387 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6X4 | FAM169A | S636 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| P63151 | PPP2R2A | S79 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q00005 | PPP2R2B | S75 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}. |
| Q12802 | AKAP13 | S906 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q66LE6 | PPP2R2D | S85 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| P08631 | HCK | S138 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| Q99426 | TBCB | Y133 | Sugiyama | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| P51659 | HSD17B4 | S75 | Sugiyama | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| O00232 | PSMD12 | S343 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O75116 | ROCK2 | S700 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| Q01082 | SPTBN1 | S2048 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q9BYP7 | WNK3 | S49 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9P0L2 | MARK1 | S447 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 9.141294e-08 | 7.039 |
| R-HSA-983189 | Kinesins | 5.605115e-07 | 6.251 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.547210e-07 | 6.256 |
| R-HSA-68886 | M Phase | 8.104766e-07 | 6.091 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.478891e-06 | 5.459 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.722782e-06 | 5.429 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.309755e-06 | 5.366 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.522666e-06 | 5.258 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 6.434096e-06 | 5.192 |
| R-HSA-69275 | G2/M Transition | 8.739690e-06 | 5.059 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.559381e-06 | 5.020 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.514732e-05 | 4.820 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.783550e-05 | 4.555 |
| R-HSA-68882 | Mitotic Anaphase | 3.153824e-05 | 4.501 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.275791e-05 | 4.485 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.160861e-05 | 4.500 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.308907e-05 | 4.275 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.498924e-05 | 4.187 |
| R-HSA-190861 | Gap junction assembly | 6.708066e-05 | 4.173 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.647824e-05 | 4.063 |
| R-HSA-3371568 | Attenuation phase | 1.265237e-04 | 3.898 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.188192e-04 | 3.925 |
| R-HSA-9646399 | Aggrephagy | 1.265237e-04 | 3.898 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.348245e-04 | 3.870 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.436128e-04 | 3.843 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.533452e-04 | 3.814 |
| R-HSA-190828 | Gap junction trafficking | 2.014756e-04 | 3.696 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.318220e-04 | 3.635 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.603405e-04 | 3.584 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.500507e-04 | 3.602 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.607358e-04 | 3.584 |
| R-HSA-437239 | Recycling pathway of L1 | 2.603405e-04 | 3.584 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.634313e-04 | 3.579 |
| R-HSA-9833482 | PKR-mediated signaling | 2.944264e-04 | 3.531 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.062818e-04 | 3.514 |
| R-HSA-68877 | Mitotic Prometaphase | 3.300030e-04 | 3.481 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.581198e-04 | 3.446 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.789337e-04 | 3.320 |
| R-HSA-68875 | Mitotic Prophase | 4.584412e-04 | 3.339 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.814185e-04 | 3.317 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.772381e-04 | 3.239 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.643032e-04 | 3.248 |
| R-HSA-3371511 | HSF1 activation | 1.005087e-03 | 2.998 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.313048e-03 | 2.882 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.521223e-03 | 2.818 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.464281e-03 | 2.834 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.464281e-03 | 2.834 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.740122e-03 | 2.759 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.714679e-03 | 2.766 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.818878e-03 | 2.740 |
| R-HSA-2262752 | Cellular responses to stress | 1.839351e-03 | 2.735 |
| R-HSA-373760 | L1CAM interactions | 2.170397e-03 | 2.663 |
| R-HSA-5620924 | Intraflagellar transport | 2.614596e-03 | 2.583 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.687664e-03 | 2.571 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.975651e-03 | 2.526 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.037809e-03 | 2.517 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.808239e-03 | 2.552 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.037809e-03 | 2.517 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 3.053060e-03 | 2.515 |
| R-HSA-9663891 | Selective autophagy | 3.173971e-03 | 2.498 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.319649e-03 | 2.479 |
| R-HSA-69481 | G2/M Checkpoints | 3.343236e-03 | 2.476 |
| R-HSA-164944 | Nef and signal transduction | 3.838688e-03 | 2.416 |
| R-HSA-391251 | Protein folding | 3.921540e-03 | 2.407 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.087998e-03 | 2.293 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.245410e-03 | 2.280 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 5.659459e-03 | 2.247 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.571884e-03 | 2.254 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.367838e-03 | 2.270 |
| R-HSA-449147 | Signaling by Interleukins | 5.963713e-03 | 2.224 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.996312e-03 | 2.222 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.996312e-03 | 2.222 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 6.691159e-03 | 2.174 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 6.691159e-03 | 2.174 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.409671e-03 | 2.130 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.219490e-03 | 2.141 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 6.623675e-03 | 2.179 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 7.421113e-03 | 2.130 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.424002e-03 | 2.129 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.496407e-03 | 2.125 |
| R-HSA-390522 | Striated Muscle Contraction | 7.948731e-03 | 2.100 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.277333e-03 | 2.082 |
| R-HSA-9675108 | Nervous system development | 8.293048e-03 | 2.081 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 8.988774e-03 | 2.046 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.842309e-03 | 2.007 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.025140e-02 | 1.989 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.154905e-02 | 1.937 |
| R-HSA-3371556 | Cellular response to heat stress | 1.226122e-02 | 1.911 |
| R-HSA-422475 | Axon guidance | 1.245311e-02 | 1.905 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.299624e-02 | 1.886 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.299624e-02 | 1.886 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.447532e-02 | 1.839 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.605510e-02 | 1.794 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.661477e-02 | 1.780 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.767094e-02 | 1.753 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.942568e-02 | 1.712 |
| R-HSA-5617833 | Cilium Assembly | 1.977080e-02 | 1.704 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.767094e-02 | 1.753 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.767094e-02 | 1.753 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.989550e-02 | 1.701 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.959596e-02 | 1.708 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.992063e-02 | 1.701 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.992063e-02 | 1.701 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.022924e-02 | 1.694 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.145224e-02 | 1.669 |
| R-HSA-1632852 | Macroautophagy | 2.246634e-02 | 1.648 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.474759e-02 | 1.606 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.667902e-02 | 1.574 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.667902e-02 | 1.574 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.667902e-02 | 1.574 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.667902e-02 | 1.574 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.737486e-02 | 1.563 |
| R-HSA-72172 | mRNA Splicing | 2.656906e-02 | 1.576 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.667902e-02 | 1.574 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.287647e-02 | 1.641 |
| R-HSA-373753 | Nephrin family interactions | 2.667902e-02 | 1.574 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.737486e-02 | 1.563 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.629983e-02 | 1.580 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.321416e-02 | 1.634 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.866938e-02 | 1.543 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.959442e-02 | 1.529 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 2.973255e-02 | 1.527 |
| R-HSA-73887 | Death Receptor Signaling | 3.077992e-02 | 1.512 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.131461e-02 | 1.504 |
| R-HSA-9612973 | Autophagy | 3.210578e-02 | 1.493 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.249740e-02 | 1.488 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.282147e-02 | 1.484 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.498056e-02 | 1.456 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.498056e-02 | 1.456 |
| R-HSA-373755 | Semaphorin interactions | 3.554650e-02 | 1.449 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.945833e-02 | 1.404 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.945833e-02 | 1.404 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.945833e-02 | 1.404 |
| R-HSA-162906 | HIV Infection | 3.974304e-02 | 1.401 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.414050e-02 | 1.355 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.414050e-02 | 1.355 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.655515e-02 | 1.332 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.655515e-02 | 1.332 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.901724e-02 | 1.310 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.177449e-02 | 1.379 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.177449e-02 | 1.379 |
| R-HSA-8939211 | ESR-mediated signaling | 4.656978e-02 | 1.332 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.086436e-02 | 1.389 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.062730e-02 | 1.296 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.213020e-02 | 1.283 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.520022e-02 | 1.258 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.667649e-02 | 1.247 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.820933e-02 | 1.235 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.931676e-02 | 1.227 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.931676e-02 | 1.227 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.931676e-02 | 1.227 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.996365e-02 | 1.222 |
| R-HSA-109703 | PKB-mediated events | 7.734685e-02 | 1.112 |
| R-HSA-165160 | PDE3B signalling | 7.734685e-02 | 1.112 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 8.185203e-02 | 1.087 |
| R-HSA-167169 | HIV Transcription Elongation | 8.185203e-02 | 1.087 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 8.185203e-02 | 1.087 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 7.890741e-02 | 1.103 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.472140e-02 | 1.189 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.159311e-02 | 1.210 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 6.801352e-02 | 1.167 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.199876e-02 | 1.208 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.472140e-02 | 1.189 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.660426e-02 | 1.176 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.599727e-02 | 1.119 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.748362e-02 | 1.171 |
| R-HSA-9682385 | FLT3 signaling in disease | 7.028436e-02 | 1.153 |
| R-HSA-9609690 | HCMV Early Events | 6.725395e-02 | 1.172 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 7.734685e-02 | 1.112 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.179613e-02 | 1.144 |
| R-HSA-1980145 | Signaling by NOTCH2 | 6.472140e-02 | 1.189 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.899182e-02 | 1.102 |
| R-HSA-199991 | Membrane Trafficking | 7.613939e-02 | 1.118 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.890741e-02 | 1.103 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 6.472140e-02 | 1.189 |
| R-HSA-109582 | Hemostasis | 6.363405e-02 | 1.196 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.185203e-02 | 1.087 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 8.483015e-02 | 1.071 |
| R-HSA-9607240 | FLT3 Signaling | 8.483015e-02 | 1.071 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.484082e-02 | 1.071 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.631985e-02 | 1.064 |
| R-HSA-9842640 | Signaling by LTK in cancer | 8.658727e-02 | 1.063 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 8.658727e-02 | 1.063 |
| R-HSA-8866423 | VLDL assembly | 8.658727e-02 | 1.063 |
| R-HSA-162582 | Signal Transduction | 8.797655e-02 | 1.056 |
| R-HSA-73894 | DNA Repair | 9.057772e-02 | 1.043 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.047931e-01 | 0.980 |
| R-HSA-164843 | 2-LTR circle formation | 1.226383e-01 | 0.911 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.314278e-01 | 0.881 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.228479e-01 | 0.911 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.261800e-01 | 0.899 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 9.827501e-02 | 1.008 |
| R-HSA-1221632 | Meiotic synapsis | 1.261800e-01 | 0.899 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.348367e-01 | 0.870 |
| R-HSA-176974 | Unwinding of DNA | 1.137603e-01 | 0.944 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.228479e-01 | 0.911 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.520870e-02 | 1.021 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.149310e-01 | 0.940 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.137603e-01 | 0.944 |
| R-HSA-8963888 | Chylomicron assembly | 1.314278e-01 | 0.881 |
| R-HSA-8964041 | LDL remodeling | 9.573573e-02 | 1.019 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.314278e-01 | 0.881 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.137603e-01 | 0.944 |
| R-HSA-9675135 | Diseases of DNA repair | 1.033499e-01 | 0.986 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 9.573573e-02 | 1.019 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.195380e-01 | 0.922 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.298961e-01 | 0.886 |
| R-HSA-211000 | Gene Silencing by RNA | 1.192524e-01 | 0.924 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.147402e-01 | 0.940 |
| R-HSA-157118 | Signaling by NOTCH | 1.231863e-01 | 0.909 |
| R-HSA-210990 | PECAM1 interactions | 1.314278e-01 | 0.881 |
| R-HSA-4839726 | Chromatin organization | 1.363813e-01 | 0.865 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 9.705874e-02 | 1.013 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.065366e-01 | 0.973 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.047931e-01 | 0.980 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.047931e-01 | 0.980 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.061453e-01 | 0.974 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.371186e-01 | 0.863 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.322573e-01 | 0.879 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.315691e-02 | 1.031 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.097496e-01 | 0.960 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.314278e-01 | 0.881 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.080878e-01 | 0.966 |
| R-HSA-75153 | Apoptotic execution phase | 1.033499e-01 | 0.986 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.337653e-01 | 0.874 |
| R-HSA-190236 | Signaling by FGFR | 9.827501e-02 | 1.008 |
| R-HSA-9609646 | HCMV Infection | 1.378851e-01 | 0.860 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.397155e-01 | 0.855 |
| R-HSA-162592 | Integration of provirus | 1.401298e-01 | 0.853 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.465973e-01 | 0.834 |
| R-HSA-5693538 | Homology Directed Repair | 1.487227e-01 | 0.828 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.487452e-01 | 0.828 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.487452e-01 | 0.828 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.740800e-01 | 0.759 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.146500e-01 | 0.668 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.225231e-01 | 0.653 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.532389e-01 | 0.596 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.532389e-01 | 0.596 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.532389e-01 | 0.596 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.607274e-01 | 0.584 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.899427e-01 | 0.538 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.899427e-01 | 0.538 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.605608e-01 | 0.794 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.605608e-01 | 0.794 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.711876e-01 | 0.767 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.963965e-01 | 0.707 |
| R-HSA-380287 | Centrosome maturation | 2.036846e-01 | 0.691 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.442019e-01 | 0.612 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.442019e-01 | 0.612 |
| R-HSA-167172 | Transcription of the HIV genome | 1.783361e-01 | 0.749 |
| R-HSA-72086 | mRNA Capping | 2.970655e-01 | 0.527 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.627504e-01 | 0.580 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.572748e-01 | 0.803 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.827483e-01 | 0.549 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.000365e-01 | 0.699 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.657195e-01 | 0.781 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.456749e-01 | 0.610 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.927651e-01 | 0.715 |
| R-HSA-6798695 | Neutrophil degranulation | 2.078834e-01 | 0.682 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.754814e-01 | 0.560 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.380348e-01 | 0.623 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.747559e-01 | 0.758 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.970655e-01 | 0.527 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.146500e-01 | 0.668 |
| R-HSA-9839394 | TGFBR3 expression | 2.681414e-01 | 0.572 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.827483e-01 | 0.549 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.146500e-01 | 0.668 |
| R-HSA-162587 | HIV Life Cycle | 2.584848e-01 | 0.588 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.572748e-01 | 0.803 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.225231e-01 | 0.653 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.963965e-01 | 0.707 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.657195e-01 | 0.781 |
| R-HSA-1500620 | Meiosis | 2.404977e-01 | 0.619 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.801944e-01 | 0.744 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.066977e-01 | 0.685 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.775987e-01 | 0.557 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.747559e-01 | 0.758 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.225231e-01 | 0.653 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.456749e-01 | 0.610 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.827483e-01 | 0.549 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.827483e-01 | 0.549 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.740800e-01 | 0.759 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.303178e-01 | 0.638 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.823573e-01 | 0.739 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.986653e-01 | 0.702 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 2.681414e-01 | 0.572 |
| R-HSA-3214842 | HDMs demethylate histones | 2.681414e-01 | 0.572 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.740800e-01 | 0.759 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.754814e-01 | 0.560 |
| R-HSA-69206 | G1/S Transition | 1.679141e-01 | 0.775 |
| R-HSA-69242 | S Phase | 2.344263e-01 | 0.630 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.607274e-01 | 0.584 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.970655e-01 | 0.527 |
| R-HSA-196108 | Pregnenolone biosynthesis | 2.225231e-01 | 0.653 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.681414e-01 | 0.572 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.970655e-01 | 0.527 |
| R-HSA-264876 | Insulin processing | 2.827483e-01 | 0.549 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.927651e-01 | 0.715 |
| R-HSA-9629569 | Protein hydroxylation | 2.225231e-01 | 0.653 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.380348e-01 | 0.623 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.855301e-01 | 0.732 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.630487e-01 | 0.788 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.664628e-01 | 0.574 |
| R-HSA-202424 | Downstream TCR signaling | 2.627504e-01 | 0.580 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.303178e-01 | 0.638 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.073402e-01 | 0.683 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.404977e-01 | 0.619 |
| R-HSA-1266738 | Developmental Biology | 2.528533e-01 | 0.597 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.986653e-01 | 0.702 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.066977e-01 | 0.685 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.681414e-01 | 0.572 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.998321e-01 | 0.523 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.998321e-01 | 0.523 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.998321e-01 | 0.523 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.146500e-01 | 0.668 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.500642e-01 | 0.824 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.500642e-01 | 0.824 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.500642e-01 | 0.824 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.500642e-01 | 0.824 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.605608e-01 | 0.794 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.607274e-01 | 0.584 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.607274e-01 | 0.584 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.827483e-01 | 0.549 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.927651e-01 | 0.715 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.607007e-01 | 0.794 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.183470e-01 | 0.661 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.665807e-01 | 0.574 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.500642e-01 | 0.824 |
| R-HSA-913531 | Interferon Signaling | 2.230964e-01 | 0.652 |
| R-HSA-109581 | Apoptosis | 2.719952e-01 | 0.565 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.000365e-01 | 0.699 |
| R-HSA-5688426 | Deubiquitination | 3.001793e-01 | 0.523 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.019582e-01 | 0.520 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.024300e-01 | 0.519 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.041172e-01 | 0.517 |
| R-HSA-2424491 | DAP12 signaling | 3.041172e-01 | 0.517 |
| R-HSA-112311 | Neurotransmitter clearance | 3.041172e-01 | 0.517 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.041172e-01 | 0.517 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.046931e-01 | 0.516 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.072222e-01 | 0.513 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.072222e-01 | 0.513 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.074291e-01 | 0.512 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.109118e-01 | 0.507 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.109118e-01 | 0.507 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.110986e-01 | 0.507 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.110986e-01 | 0.507 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.145975e-01 | 0.502 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.180103e-01 | 0.498 |
| R-HSA-69190 | DNA strand elongation | 3.180103e-01 | 0.498 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.248532e-01 | 0.488 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.248532e-01 | 0.488 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.248532e-01 | 0.488 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.292949e-01 | 0.482 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.316278e-01 | 0.479 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.316278e-01 | 0.479 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.316278e-01 | 0.479 |
| R-HSA-69239 | Synthesis of DNA | 3.366125e-01 | 0.473 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.383349e-01 | 0.471 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.383349e-01 | 0.471 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.383349e-01 | 0.471 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.383349e-01 | 0.471 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.402626e-01 | 0.468 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.439066e-01 | 0.464 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.439066e-01 | 0.464 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.449750e-01 | 0.462 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.449750e-01 | 0.462 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.449750e-01 | 0.462 |
| R-HSA-169911 | Regulation of Apoptosis | 3.449750e-01 | 0.462 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.449750e-01 | 0.462 |
| R-HSA-202403 | TCR signaling | 3.475443e-01 | 0.459 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.475443e-01 | 0.459 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.475443e-01 | 0.459 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.515490e-01 | 0.454 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.515490e-01 | 0.454 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.515490e-01 | 0.454 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.515490e-01 | 0.454 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.539797e-01 | 0.451 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.567125e-01 | 0.448 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.580573e-01 | 0.446 |
| R-HSA-4641258 | Degradation of DVL | 3.580573e-01 | 0.446 |
| R-HSA-4641257 | Degradation of AXIN | 3.580573e-01 | 0.446 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.580573e-01 | 0.446 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 3.580573e-01 | 0.446 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.584168e-01 | 0.446 |
| R-HSA-8953854 | Metabolism of RNA | 3.601200e-01 | 0.444 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 3.645008e-01 | 0.438 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.692238e-01 | 0.433 |
| R-HSA-112316 | Neuronal System | 3.696760e-01 | 0.432 |
| R-HSA-9824446 | Viral Infection Pathways | 3.706410e-01 | 0.431 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.708799e-01 | 0.431 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.708799e-01 | 0.431 |
| R-HSA-69541 | Stabilization of p53 | 3.708799e-01 | 0.431 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.771954e-01 | 0.423 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.771954e-01 | 0.423 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.771954e-01 | 0.423 |
| R-HSA-202433 | Generation of second messenger molecules | 3.771954e-01 | 0.423 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.771954e-01 | 0.423 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.771954e-01 | 0.423 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.771954e-01 | 0.423 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.834479e-01 | 0.416 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.834479e-01 | 0.416 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.834479e-01 | 0.416 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.834479e-01 | 0.416 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.834479e-01 | 0.416 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.870747e-01 | 0.412 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.870747e-01 | 0.412 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.896381e-01 | 0.409 |
| R-HSA-167161 | HIV Transcription Initiation | 3.896381e-01 | 0.409 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.896381e-01 | 0.409 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.896381e-01 | 0.409 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.896381e-01 | 0.409 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.896381e-01 | 0.409 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.896381e-01 | 0.409 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.896381e-01 | 0.409 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.896381e-01 | 0.409 |
| R-HSA-73886 | Chromosome Maintenance | 3.941542e-01 | 0.404 |
| R-HSA-5357801 | Programmed Cell Death | 3.947656e-01 | 0.404 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.957664e-01 | 0.403 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.957664e-01 | 0.403 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.976803e-01 | 0.400 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.976803e-01 | 0.400 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.018336e-01 | 0.396 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.018336e-01 | 0.396 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.018336e-01 | 0.396 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.047040e-01 | 0.393 |
| R-HSA-2172127 | DAP12 interactions | 4.078402e-01 | 0.390 |
| R-HSA-9907900 | Proteasome assembly | 4.078402e-01 | 0.390 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.078402e-01 | 0.390 |
| R-HSA-69236 | G1 Phase | 4.078402e-01 | 0.390 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.078402e-01 | 0.390 |
| R-HSA-397014 | Muscle contraction | 4.135880e-01 | 0.383 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.137869e-01 | 0.383 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.137869e-01 | 0.383 |
| R-HSA-774815 | Nucleosome assembly | 4.137869e-01 | 0.383 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.137869e-01 | 0.383 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.137869e-01 | 0.383 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.137869e-01 | 0.383 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.137869e-01 | 0.383 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.137869e-01 | 0.383 |
| R-HSA-9824272 | Somitogenesis | 4.137869e-01 | 0.383 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.137869e-01 | 0.383 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.196743e-01 | 0.377 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.196743e-01 | 0.377 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.220905e-01 | 0.375 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.255028e-01 | 0.371 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.255028e-01 | 0.371 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 4.255028e-01 | 0.371 |
| R-HSA-597592 | Post-translational protein modification | 4.258283e-01 | 0.371 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.312732e-01 | 0.365 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.312732e-01 | 0.365 |
| R-HSA-1474165 | Reproduction | 4.323981e-01 | 0.364 |
| R-HSA-9766229 | Degradation of CDH1 | 4.369860e-01 | 0.360 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.369860e-01 | 0.360 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.369860e-01 | 0.360 |
| R-HSA-8951664 | Neddylation | 4.375149e-01 | 0.359 |
| R-HSA-1500931 | Cell-Cell communication | 4.381935e-01 | 0.358 |
| R-HSA-109704 | PI3K Cascade | 4.426418e-01 | 0.354 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.426418e-01 | 0.354 |
| R-HSA-9748787 | Azathioprine ADME | 4.426418e-01 | 0.354 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.426418e-01 | 0.354 |
| R-HSA-912446 | Meiotic recombination | 4.482411e-01 | 0.348 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.482411e-01 | 0.348 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.482411e-01 | 0.348 |
| R-HSA-72187 | mRNA 3'-end processing | 4.537844e-01 | 0.343 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.537844e-01 | 0.343 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.537844e-01 | 0.343 |
| R-HSA-8957322 | Metabolism of steroids | 4.559455e-01 | 0.341 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.560630e-01 | 0.341 |
| R-HSA-163685 | Integration of energy metabolism | 4.560630e-01 | 0.341 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.592725e-01 | 0.338 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.592725e-01 | 0.338 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.592725e-01 | 0.338 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.592725e-01 | 0.338 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.592725e-01 | 0.338 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.647057e-01 | 0.333 |
| R-HSA-6807070 | PTEN Regulation | 4.660322e-01 | 0.332 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.693314e-01 | 0.329 |
| R-HSA-9664407 | Parasite infection | 4.693314e-01 | 0.329 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.693314e-01 | 0.329 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.700846e-01 | 0.328 |
| R-HSA-9753281 | Paracetamol ADME | 4.700846e-01 | 0.328 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.726186e-01 | 0.325 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.754099e-01 | 0.323 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.754099e-01 | 0.323 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.754099e-01 | 0.323 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.791564e-01 | 0.320 |
| R-HSA-112399 | IRS-mediated signalling | 4.806819e-01 | 0.318 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.806819e-01 | 0.318 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.859013e-01 | 0.313 |
| R-HSA-9033241 | Peroxisomal protein import | 4.910686e-01 | 0.309 |
| R-HSA-168249 | Innate Immune System | 4.933514e-01 | 0.307 |
| R-HSA-351202 | Metabolism of polyamines | 4.961842e-01 | 0.304 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.961842e-01 | 0.304 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.984714e-01 | 0.302 |
| R-HSA-166520 | Signaling by NTRKs | 4.984714e-01 | 0.302 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.012488e-01 | 0.300 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.012488e-01 | 0.300 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.012488e-01 | 0.300 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.012488e-01 | 0.300 |
| R-HSA-450294 | MAP kinase activation | 5.012488e-01 | 0.300 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.012488e-01 | 0.300 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.048083e-01 | 0.297 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.062627e-01 | 0.296 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.062627e-01 | 0.296 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.079575e-01 | 0.294 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.110936e-01 | 0.291 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.112265e-01 | 0.291 |
| R-HSA-69306 | DNA Replication | 5.142168e-01 | 0.289 |
| R-HSA-9609507 | Protein localization | 5.142168e-01 | 0.289 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.161408e-01 | 0.287 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.161408e-01 | 0.287 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.210059e-01 | 0.283 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.210059e-01 | 0.283 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.210059e-01 | 0.283 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.258224e-01 | 0.279 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.305908e-01 | 0.275 |
| R-HSA-196071 | Metabolism of steroid hormones | 5.305908e-01 | 0.275 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.353115e-01 | 0.271 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.353115e-01 | 0.271 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.353115e-01 | 0.271 |
| R-HSA-168256 | Immune System | 5.404863e-01 | 0.267 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.446118e-01 | 0.264 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.446118e-01 | 0.264 |
| R-HSA-448424 | Interleukin-17 signaling | 5.446118e-01 | 0.264 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.446118e-01 | 0.264 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.446118e-01 | 0.264 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.491924e-01 | 0.260 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.491924e-01 | 0.260 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.491924e-01 | 0.260 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.491924e-01 | 0.260 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.537272e-01 | 0.257 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.537272e-01 | 0.257 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.552989e-01 | 0.255 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.582166e-01 | 0.253 |
| R-HSA-4086398 | Ca2+ pathway | 5.582166e-01 | 0.253 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.626612e-01 | 0.250 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.670613e-01 | 0.246 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.670613e-01 | 0.246 |
| R-HSA-418555 | G alpha (s) signalling events | 5.710236e-01 | 0.243 |
| R-HSA-5689603 | UCH proteinases | 5.714174e-01 | 0.243 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.714174e-01 | 0.243 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.767182e-01 | 0.239 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.767182e-01 | 0.239 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.799993e-01 | 0.237 |
| R-HSA-5619084 | ABC transporter disorders | 5.799993e-01 | 0.237 |
| R-HSA-4086400 | PCP/CE pathway | 5.799993e-01 | 0.237 |
| R-HSA-9659379 | Sensory processing of sound | 5.842260e-01 | 0.233 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.884105e-01 | 0.230 |
| R-HSA-2559583 | Cellular Senescence | 5.962163e-01 | 0.225 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.966542e-01 | 0.224 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.966542e-01 | 0.224 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.007143e-01 | 0.221 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 6.047338e-01 | 0.218 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.047338e-01 | 0.218 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.087131e-01 | 0.216 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.126526e-01 | 0.213 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.126526e-01 | 0.213 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.160225e-01 | 0.210 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.165526e-01 | 0.210 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.165526e-01 | 0.210 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.242360e-01 | 0.205 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.280201e-01 | 0.202 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.354751e-01 | 0.197 |
| R-HSA-1280218 | Adaptive Immune System | 6.367628e-01 | 0.196 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.382505e-01 | 0.195 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.427816e-01 | 0.192 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.427816e-01 | 0.192 |
| R-HSA-2029481 | FCGR activation | 6.463801e-01 | 0.190 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.499425e-01 | 0.187 |
| R-HSA-1474290 | Collagen formation | 6.499425e-01 | 0.187 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.555394e-01 | 0.183 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.569608e-01 | 0.182 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.604173e-01 | 0.180 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.604173e-01 | 0.180 |
| R-HSA-372790 | Signaling by GPCR | 6.624323e-01 | 0.179 |
| R-HSA-157579 | Telomere Maintenance | 6.638391e-01 | 0.178 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.638391e-01 | 0.178 |
| R-HSA-6805567 | Keratinization | 6.651214e-01 | 0.177 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.672268e-01 | 0.176 |
| R-HSA-3214847 | HATs acetylate histones | 6.705804e-01 | 0.174 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.705804e-01 | 0.174 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.836626e-01 | 0.165 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.868516e-01 | 0.163 |
| R-HSA-1474244 | Extracellular matrix organization | 6.879526e-01 | 0.162 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.900087e-01 | 0.161 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.900087e-01 | 0.161 |
| R-HSA-418990 | Adherens junctions interactions | 6.925897e-01 | 0.160 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.023238e-01 | 0.153 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.023238e-01 | 0.153 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.053259e-01 | 0.152 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.078279e-01 | 0.150 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.082978e-01 | 0.150 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.098583e-01 | 0.149 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.141526e-01 | 0.146 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.141526e-01 | 0.146 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.141526e-01 | 0.146 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.165389e-01 | 0.145 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.170361e-01 | 0.144 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.198906e-01 | 0.143 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.255141e-01 | 0.139 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.282837e-01 | 0.138 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.337397e-01 | 0.134 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.337397e-01 | 0.134 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.364268e-01 | 0.133 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.390869e-01 | 0.131 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.443273e-01 | 0.128 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.494631e-01 | 0.125 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.494631e-01 | 0.125 |
| R-HSA-194138 | Signaling by VEGF | 7.569751e-01 | 0.121 |
| R-HSA-421270 | Cell-cell junction organization | 7.586863e-01 | 0.120 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.594290e-01 | 0.120 |
| R-HSA-114608 | Platelet degranulation | 7.618584e-01 | 0.118 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.690010e-01 | 0.114 |
| R-HSA-9909396 | Circadian clock | 7.759306e-01 | 0.110 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.759306e-01 | 0.110 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.781943e-01 | 0.109 |
| R-HSA-5368287 | Mitochondrial translation | 7.913068e-01 | 0.102 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.913068e-01 | 0.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.972082e-01 | 0.098 |
| R-HSA-446728 | Cell junction organization | 8.033276e-01 | 0.095 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.056339e-01 | 0.094 |
| R-HSA-9658195 | Leishmania infection | 8.078098e-01 | 0.093 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.078098e-01 | 0.093 |
| R-HSA-9758941 | Gastrulation | 8.152648e-01 | 0.089 |
| R-HSA-388396 | GPCR downstream signalling | 8.154927e-01 | 0.089 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.171333e-01 | 0.088 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.193233e-01 | 0.087 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.208142e-01 | 0.086 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.261978e-01 | 0.083 |
| R-HSA-5663205 | Infectious disease | 8.281377e-01 | 0.082 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.288901e-01 | 0.082 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.314207e-01 | 0.080 |
| R-HSA-195721 | Signaling by WNT | 8.315390e-01 | 0.080 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.523087e-01 | 0.069 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.538046e-01 | 0.069 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.567513e-01 | 0.067 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.567513e-01 | 0.067 |
| R-HSA-74160 | Gene expression (Transcription) | 8.612556e-01 | 0.065 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.616759e-01 | 0.065 |
| R-HSA-392499 | Metabolism of proteins | 8.625321e-01 | 0.064 |
| R-HSA-611105 | Respiratory electron transport | 8.638624e-01 | 0.064 |
| R-HSA-168255 | Influenza Infection | 8.652420e-01 | 0.063 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.706226e-01 | 0.060 |
| R-HSA-212436 | Generic Transcription Pathway | 8.768239e-01 | 0.057 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.770490e-01 | 0.057 |
| R-HSA-983712 | Ion channel transport | 8.782957e-01 | 0.056 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.831581e-01 | 0.054 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.907489e-01 | 0.050 |
| R-HSA-428157 | Sphingolipid metabolism | 8.923112e-01 | 0.049 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.944859e-01 | 0.048 |
| R-HSA-1643685 | Disease | 9.022833e-01 | 0.045 |
| R-HSA-9748784 | Drug ADME | 9.103827e-01 | 0.041 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.207214e-01 | 0.036 |
| R-HSA-72312 | rRNA processing | 9.223253e-01 | 0.035 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.261955e-01 | 0.033 |
| R-HSA-8978868 | Fatty acid metabolism | 9.309776e-01 | 0.031 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.333701e-01 | 0.030 |
| R-HSA-382551 | Transport of small molecules | 9.416528e-01 | 0.026 |
| R-HSA-72766 | Translation | 9.426526e-01 | 0.026 |
| R-HSA-500792 | GPCR ligand binding | 9.470486e-01 | 0.024 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.534413e-01 | 0.021 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.746017e-01 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.799583e-01 | 0.009 |
| R-HSA-9679506 | SARS-CoV Infections | 9.808142e-01 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.836935e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.858879e-01 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.922563e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.985834e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.995117e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999981e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.821 | 0.641 | 2 | 0.908 |
CAMK2B |
0.780 | 0.290 | 2 | 0.550 |
CLK3 |
0.775 | 0.142 | 1 | 0.801 |
CAMK2G |
0.773 | 0.194 | 2 | 0.485 |
COT |
0.773 | 0.088 | 2 | 0.436 |
CAMK2A |
0.766 | 0.165 | 2 | 0.484 |
CDC7 |
0.766 | 0.063 | 1 | 0.893 |
CAMK2D |
0.765 | 0.171 | -3 | 0.844 |
GRK1 |
0.765 | 0.170 | -2 | 0.746 |
MAPKAPK2 |
0.765 | 0.156 | -3 | 0.760 |
GRK6 |
0.763 | 0.183 | 1 | 0.820 |
CAMK1B |
0.763 | 0.051 | -3 | 0.881 |
PRPK |
0.763 | 0.049 | -1 | 0.836 |
PIM3 |
0.763 | 0.066 | -3 | 0.827 |
MOS |
0.762 | 0.063 | 1 | 0.862 |
PIM1 |
0.762 | 0.098 | -3 | 0.814 |
IKKB |
0.761 | 0.069 | -2 | 0.783 |
DSTYK |
0.759 | 0.062 | 2 | 0.477 |
SKMLCK |
0.759 | 0.101 | -2 | 0.850 |
RSK2 |
0.758 | 0.074 | -3 | 0.805 |
NDR2 |
0.757 | 0.030 | -3 | 0.819 |
CK2A2 |
0.756 | 0.284 | 1 | 0.736 |
RAF1 |
0.756 | -0.055 | 1 | 0.790 |
ATR |
0.755 | 0.021 | 1 | 0.789 |
BMPR1B |
0.755 | 0.144 | 1 | 0.838 |
LATS2 |
0.755 | 0.070 | -5 | 0.786 |
BMPR2 |
0.754 | -0.024 | -2 | 0.871 |
CLK2 |
0.754 | 0.124 | -3 | 0.785 |
ATM |
0.754 | 0.112 | 1 | 0.760 |
PDHK4 |
0.754 | 0.006 | 1 | 0.793 |
PRKD1 |
0.754 | 0.046 | -3 | 0.815 |
TGFBR1 |
0.753 | 0.138 | -2 | 0.790 |
PKN3 |
0.753 | 0.013 | -3 | 0.823 |
IKKA |
0.753 | 0.088 | -2 | 0.764 |
ALK2 |
0.753 | 0.212 | -2 | 0.789 |
GRK5 |
0.752 | 0.023 | -3 | 0.821 |
MAPKAPK3 |
0.752 | 0.067 | -3 | 0.794 |
LATS1 |
0.752 | 0.169 | -3 | 0.813 |
SRPK1 |
0.752 | 0.053 | -3 | 0.784 |
P90RSK |
0.751 | 0.041 | -3 | 0.794 |
MTOR |
0.750 | -0.082 | 1 | 0.746 |
MARK4 |
0.750 | -0.006 | 4 | 0.417 |
DAPK2 |
0.750 | -0.004 | -3 | 0.868 |
CDKL1 |
0.750 | 0.003 | -3 | 0.822 |
MST4 |
0.750 | -0.049 | 2 | 0.391 |
CAMLCK |
0.750 | 0.011 | -2 | 0.844 |
P70S6KB |
0.749 | 0.021 | -3 | 0.828 |
PRKD2 |
0.749 | 0.036 | -3 | 0.799 |
ULK2 |
0.749 | -0.134 | 2 | 0.350 |
TBK1 |
0.749 | -0.062 | 1 | 0.679 |
NIK |
0.749 | -0.063 | -3 | 0.875 |
NLK |
0.749 | -0.080 | 1 | 0.767 |
GCN2 |
0.749 | -0.152 | 2 | 0.354 |
WNK1 |
0.749 | -0.026 | -2 | 0.887 |
PDHK1 |
0.748 | -0.094 | 1 | 0.772 |
RSK4 |
0.748 | 0.079 | -3 | 0.761 |
GRK7 |
0.748 | 0.127 | 1 | 0.752 |
NDR1 |
0.748 | -0.021 | -3 | 0.836 |
CK2A1 |
0.747 | 0.251 | 1 | 0.713 |
DNAPK |
0.747 | 0.130 | 1 | 0.683 |
BMPR1A |
0.746 | 0.151 | 1 | 0.846 |
AMPKA1 |
0.746 | -0.032 | -3 | 0.857 |
BCKDK |
0.745 | -0.032 | -1 | 0.804 |
TSSK2 |
0.745 | 0.001 | -5 | 0.833 |
PKCD |
0.745 | -0.043 | 2 | 0.343 |
RSK3 |
0.745 | 0.016 | -3 | 0.789 |
ALK4 |
0.744 | 0.042 | -2 | 0.816 |
IKKE |
0.744 | -0.065 | 1 | 0.672 |
HIPK4 |
0.744 | -0.019 | 1 | 0.699 |
MSK2 |
0.743 | 0.044 | -3 | 0.768 |
PKACG |
0.743 | 0.015 | -2 | 0.770 |
ICK |
0.743 | -0.006 | -3 | 0.843 |
MSK1 |
0.743 | 0.068 | -3 | 0.774 |
CHAK2 |
0.743 | -0.079 | -1 | 0.859 |
PLK3 |
0.743 | 0.096 | 2 | 0.435 |
SRPK2 |
0.743 | 0.043 | -3 | 0.721 |
PKN2 |
0.743 | -0.066 | -3 | 0.855 |
CLK4 |
0.743 | 0.047 | -3 | 0.810 |
ERK5 |
0.742 | -0.059 | 1 | 0.698 |
ACVR2B |
0.741 | 0.073 | -2 | 0.770 |
PAK1 |
0.741 | 0.007 | -2 | 0.767 |
GRK4 |
0.741 | -0.001 | -2 | 0.784 |
PRKX |
0.741 | 0.089 | -3 | 0.722 |
HUNK |
0.741 | -0.090 | 2 | 0.351 |
NUAK2 |
0.741 | -0.052 | -3 | 0.855 |
NEK6 |
0.740 | -0.119 | -2 | 0.849 |
DLK |
0.740 | -0.080 | 1 | 0.785 |
ULK1 |
0.740 | -0.114 | -3 | 0.767 |
ACVR2A |
0.740 | 0.057 | -2 | 0.759 |
PLK1 |
0.740 | 0.013 | -2 | 0.778 |
RIPK3 |
0.740 | -0.121 | 3 | 0.565 |
CDKL5 |
0.740 | -0.026 | -3 | 0.817 |
MLK1 |
0.739 | -0.142 | 2 | 0.363 |
WNK3 |
0.739 | -0.154 | 1 | 0.739 |
CAMK4 |
0.739 | -0.030 | -3 | 0.842 |
PKACB |
0.739 | 0.056 | -2 | 0.693 |
NEK7 |
0.739 | -0.162 | -3 | 0.782 |
TSSK1 |
0.739 | -0.036 | -3 | 0.864 |
NIM1 |
0.739 | -0.069 | 3 | 0.585 |
TGFBR2 |
0.738 | -0.106 | -2 | 0.758 |
MASTL |
0.738 | -0.149 | -2 | 0.829 |
CLK1 |
0.738 | 0.037 | -3 | 0.802 |
MARK2 |
0.738 | -0.017 | 4 | 0.359 |
AMPKA2 |
0.738 | -0.035 | -3 | 0.836 |
AURC |
0.738 | 0.007 | -2 | 0.662 |
MEK1 |
0.737 | -0.082 | 2 | 0.402 |
PRKD3 |
0.737 | 0.004 | -3 | 0.788 |
KIS |
0.737 | 0.005 | 1 | 0.643 |
TTBK2 |
0.736 | -0.104 | 2 | 0.309 |
PKR |
0.736 | -0.059 | 1 | 0.738 |
CHK1 |
0.736 | 0.021 | -3 | 0.809 |
ANKRD3 |
0.736 | -0.170 | 1 | 0.775 |
MYLK4 |
0.735 | 0.012 | -2 | 0.774 |
BRAF |
0.735 | 0.019 | -4 | 0.786 |
MNK2 |
0.735 | -0.017 | -2 | 0.805 |
SRPK3 |
0.735 | 0.010 | -3 | 0.757 |
PKCG |
0.734 | -0.067 | 2 | 0.304 |
MARK3 |
0.734 | -0.029 | 4 | 0.363 |
RIPK1 |
0.734 | -0.112 | 1 | 0.729 |
DCAMKL1 |
0.733 | 0.001 | -3 | 0.807 |
PAK3 |
0.733 | -0.049 | -2 | 0.776 |
PIM2 |
0.733 | 0.031 | -3 | 0.792 |
BRSK1 |
0.733 | -0.021 | -3 | 0.809 |
PKCB |
0.733 | -0.059 | 2 | 0.302 |
SGK3 |
0.733 | 0.013 | -3 | 0.792 |
PKCA |
0.732 | -0.076 | 2 | 0.299 |
CDK8 |
0.732 | -0.018 | 1 | 0.634 |
MNK1 |
0.732 | -0.020 | -2 | 0.806 |
PAK6 |
0.731 | -0.010 | -2 | 0.709 |
MELK |
0.731 | -0.063 | -3 | 0.827 |
MLK2 |
0.731 | -0.178 | 2 | 0.369 |
AURA |
0.731 | 0.012 | -2 | 0.621 |
MAPKAPK5 |
0.731 | 0.014 | -3 | 0.743 |
DCAMKL2 |
0.731 | -0.013 | -3 | 0.838 |
NEK9 |
0.731 | -0.184 | 2 | 0.359 |
CAMK1D |
0.731 | 0.061 | -3 | 0.740 |
QSK |
0.731 | -0.055 | 4 | 0.393 |
DYRK2 |
0.731 | 0.008 | 1 | 0.616 |
JNK2 |
0.731 | 0.028 | 1 | 0.587 |
DRAK1 |
0.730 | -0.045 | 1 | 0.750 |
AURB |
0.730 | -0.012 | -2 | 0.663 |
AKT2 |
0.730 | 0.011 | -3 | 0.747 |
JNK3 |
0.729 | 0.022 | 1 | 0.618 |
PKCH |
0.729 | -0.085 | 2 | 0.290 |
VRK2 |
0.729 | -0.224 | 1 | 0.794 |
MARK1 |
0.729 | -0.034 | 4 | 0.376 |
PAK2 |
0.728 | -0.048 | -2 | 0.754 |
NUAK1 |
0.728 | -0.064 | -3 | 0.817 |
SIK |
0.728 | -0.051 | -3 | 0.791 |
PASK |
0.728 | 0.036 | -3 | 0.831 |
GSK3A |
0.728 | -0.019 | 4 | 0.188 |
PKG2 |
0.728 | -0.009 | -2 | 0.702 |
TLK2 |
0.728 | -0.066 | 1 | 0.711 |
PHKG1 |
0.728 | -0.108 | -3 | 0.835 |
QIK |
0.728 | -0.118 | -3 | 0.841 |
SMG1 |
0.727 | -0.024 | 1 | 0.739 |
CDK5 |
0.727 | -0.030 | 1 | 0.648 |
GRK2 |
0.727 | -0.011 | -2 | 0.701 |
MLK3 |
0.726 | -0.134 | 2 | 0.321 |
DAPK3 |
0.726 | 0.040 | -3 | 0.825 |
NEK2 |
0.726 | -0.121 | 2 | 0.344 |
IRE1 |
0.726 | -0.190 | 1 | 0.682 |
CDK1 |
0.726 | -0.011 | 1 | 0.597 |
MLK4 |
0.726 | -0.124 | 2 | 0.315 |
CAMK1G |
0.726 | -0.028 | -3 | 0.805 |
DYRK4 |
0.725 | 0.041 | 1 | 0.567 |
IRE2 |
0.725 | -0.158 | 2 | 0.320 |
PRP4 |
0.725 | -0.019 | -3 | 0.708 |
PKACA |
0.725 | 0.042 | -2 | 0.652 |
BRSK2 |
0.725 | -0.086 | -3 | 0.834 |
CDK19 |
0.725 | -0.021 | 1 | 0.598 |
YSK4 |
0.725 | -0.142 | 1 | 0.720 |
PKCZ |
0.724 | -0.102 | 2 | 0.328 |
SMMLCK |
0.724 | -0.015 | -3 | 0.847 |
CDK7 |
0.724 | -0.040 | 1 | 0.638 |
SSTK |
0.724 | -0.042 | 4 | 0.375 |
GSK3B |
0.724 | -0.055 | 4 | 0.171 |
PLK2 |
0.724 | 0.066 | -3 | 0.728 |
CDK18 |
0.724 | -0.028 | 1 | 0.565 |
CDK13 |
0.724 | -0.026 | 1 | 0.612 |
SNRK |
0.723 | -0.145 | 2 | 0.296 |
PLK4 |
0.723 | -0.114 | 2 | 0.267 |
HIPK1 |
0.723 | -0.000 | 1 | 0.636 |
CDK2 |
0.722 | -0.041 | 1 | 0.664 |
CHAK1 |
0.722 | -0.181 | 2 | 0.332 |
HIPK2 |
0.721 | 0.010 | 1 | 0.543 |
ZAK |
0.721 | -0.154 | 1 | 0.736 |
WNK4 |
0.721 | -0.103 | -2 | 0.876 |
DYRK1A |
0.720 | -0.007 | 1 | 0.680 |
P38A |
0.720 | -0.033 | 1 | 0.630 |
CDK3 |
0.719 | 0.005 | 1 | 0.539 |
DAPK1 |
0.719 | 0.027 | -3 | 0.816 |
CDK9 |
0.719 | -0.031 | 1 | 0.617 |
P70S6K |
0.719 | -0.020 | -3 | 0.756 |
PKCT |
0.719 | -0.081 | 2 | 0.295 |
MEKK1 |
0.718 | -0.174 | 1 | 0.737 |
GAK |
0.718 | -0.021 | 1 | 0.765 |
MEK5 |
0.718 | -0.236 | 2 | 0.373 |
PERK |
0.718 | -0.165 | -2 | 0.811 |
MEKK3 |
0.718 | -0.132 | 1 | 0.729 |
AKT1 |
0.718 | -0.007 | -3 | 0.757 |
MST3 |
0.718 | -0.128 | 2 | 0.354 |
CDK12 |
0.718 | -0.024 | 1 | 0.586 |
SBK |
0.717 | 0.069 | -3 | 0.649 |
P38B |
0.717 | -0.008 | 1 | 0.570 |
P38G |
0.717 | -0.009 | 1 | 0.516 |
TAO3 |
0.717 | -0.104 | 1 | 0.733 |
CAMKK1 |
0.717 | -0.055 | -2 | 0.789 |
PHKG2 |
0.716 | -0.092 | -3 | 0.844 |
ERK7 |
0.716 | -0.052 | 2 | 0.233 |
TLK1 |
0.716 | -0.120 | -2 | 0.800 |
CK1E |
0.716 | -0.031 | -3 | 0.550 |
SGK1 |
0.716 | 0.042 | -3 | 0.672 |
CDK17 |
0.715 | -0.036 | 1 | 0.521 |
DYRK1B |
0.715 | 0.011 | 1 | 0.587 |
TTBK1 |
0.715 | -0.108 | 2 | 0.274 |
PINK1 |
0.715 | -0.151 | 1 | 0.727 |
GRK3 |
0.715 | -0.000 | -2 | 0.648 |
IRAK4 |
0.714 | -0.171 | 1 | 0.703 |
MEKK2 |
0.714 | -0.184 | 2 | 0.354 |
HIPK3 |
0.713 | -0.036 | 1 | 0.628 |
PKCE |
0.713 | -0.059 | 2 | 0.293 |
PDK1 |
0.713 | -0.069 | 1 | 0.734 |
PKCI |
0.713 | -0.091 | 2 | 0.305 |
HRI |
0.713 | -0.207 | -2 | 0.831 |
NEK5 |
0.713 | -0.177 | 1 | 0.738 |
ERK2 |
0.713 | -0.056 | 1 | 0.614 |
P38D |
0.712 | -0.001 | 1 | 0.541 |
ERK1 |
0.712 | -0.041 | 1 | 0.566 |
DYRK3 |
0.712 | -0.001 | 1 | 0.628 |
CDK14 |
0.711 | -0.045 | 1 | 0.603 |
YANK3 |
0.711 | -0.029 | 2 | 0.216 |
TAO2 |
0.711 | -0.133 | 2 | 0.386 |
IRAK1 |
0.711 | -0.136 | -1 | 0.756 |
JNK1 |
0.711 | 0.009 | 1 | 0.580 |
LKB1 |
0.710 | -0.095 | -3 | 0.779 |
CK1D |
0.710 | -0.020 | -3 | 0.505 |
CDK10 |
0.710 | -0.030 | 1 | 0.590 |
MPSK1 |
0.709 | -0.090 | 1 | 0.672 |
CDK16 |
0.709 | -0.032 | 1 | 0.538 |
ROCK2 |
0.708 | 0.007 | -3 | 0.811 |
PAK5 |
0.708 | -0.042 | -2 | 0.635 |
CAMKK2 |
0.708 | -0.095 | -2 | 0.794 |
CHK2 |
0.708 | -0.015 | -3 | 0.710 |
CAMK1A |
0.708 | 0.002 | -3 | 0.722 |
TNIK |
0.707 | -0.089 | 3 | 0.658 |
PDHK3_TYR |
0.707 | 0.200 | 4 | 0.500 |
NEK8 |
0.707 | -0.201 | 2 | 0.352 |
EEF2K |
0.707 | -0.106 | 3 | 0.637 |
AKT3 |
0.707 | 0.004 | -3 | 0.685 |
MRCKB |
0.706 | -0.004 | -3 | 0.790 |
GCK |
0.706 | -0.098 | 1 | 0.722 |
PAK4 |
0.706 | -0.038 | -2 | 0.637 |
NEK11 |
0.706 | -0.213 | 1 | 0.733 |
PKN1 |
0.706 | -0.055 | -3 | 0.778 |
CK1A2 |
0.705 | -0.036 | -3 | 0.512 |
MINK |
0.705 | -0.114 | 1 | 0.708 |
TAK1 |
0.705 | -0.111 | 1 | 0.770 |
MRCKA |
0.705 | -0.010 | -3 | 0.796 |
STK33 |
0.704 | -0.105 | 2 | 0.273 |
MAP3K15 |
0.704 | -0.172 | 1 | 0.718 |
NEK4 |
0.703 | -0.177 | 1 | 0.698 |
LRRK2 |
0.703 | -0.161 | 2 | 0.383 |
HGK |
0.702 | -0.141 | 3 | 0.643 |
MST2 |
0.702 | -0.154 | 1 | 0.735 |
HPK1 |
0.701 | -0.105 | 1 | 0.705 |
DMPK1 |
0.701 | 0.016 | -3 | 0.816 |
MEKK6 |
0.701 | -0.213 | 1 | 0.722 |
LOK |
0.700 | -0.129 | -2 | 0.803 |
KHS2 |
0.700 | -0.073 | 1 | 0.705 |
MAP2K6_TYR |
0.700 | 0.116 | -1 | 0.871 |
KHS1 |
0.700 | -0.091 | 1 | 0.690 |
CK1G1 |
0.699 | -0.073 | -3 | 0.536 |
PDHK4_TYR |
0.699 | 0.111 | 2 | 0.458 |
CDK6 |
0.699 | -0.052 | 1 | 0.587 |
PBK |
0.699 | -0.053 | 1 | 0.669 |
MAK |
0.699 | 0.010 | -2 | 0.676 |
CDK4 |
0.699 | -0.039 | 1 | 0.571 |
VRK1 |
0.698 | -0.187 | 2 | 0.370 |
MEK2 |
0.698 | -0.182 | 2 | 0.364 |
NEK1 |
0.697 | -0.173 | 1 | 0.711 |
SLK |
0.697 | -0.103 | -2 | 0.741 |
MAP2K4_TYR |
0.697 | 0.025 | -1 | 0.859 |
EPHA6 |
0.696 | 0.065 | -1 | 0.855 |
CRIK |
0.696 | 0.015 | -3 | 0.749 |
TESK1_TYR |
0.696 | -0.035 | 3 | 0.685 |
ALPHAK3 |
0.696 | 0.083 | -1 | 0.765 |
MOK |
0.695 | -0.012 | 1 | 0.612 |
PDHK1_TYR |
0.694 | 0.053 | -1 | 0.881 |
EPHA4 |
0.694 | 0.117 | 2 | 0.448 |
BMPR2_TYR |
0.694 | 0.050 | -1 | 0.867 |
MST1 |
0.694 | -0.166 | 1 | 0.705 |
YSK1 |
0.694 | -0.168 | 2 | 0.338 |
BUB1 |
0.694 | -0.061 | -5 | 0.797 |
RIPK2 |
0.693 | -0.187 | 1 | 0.691 |
MAP2K7_TYR |
0.693 | -0.041 | 2 | 0.429 |
ROCK1 |
0.693 | -0.015 | -3 | 0.797 |
OSR1 |
0.691 | -0.125 | 2 | 0.341 |
PKMYT1_TYR |
0.691 | -0.102 | 3 | 0.652 |
LIMK2_TYR |
0.690 | -0.072 | -3 | 0.864 |
PINK1_TYR |
0.690 | -0.093 | 1 | 0.780 |
HASPIN |
0.690 | -0.024 | -1 | 0.776 |
NEK3 |
0.689 | -0.182 | 1 | 0.686 |
BIKE |
0.689 | -0.012 | 1 | 0.639 |
ASK1 |
0.689 | -0.115 | 1 | 0.720 |
PKG1 |
0.689 | -0.035 | -2 | 0.620 |
EPHB4 |
0.688 | 0.014 | -1 | 0.819 |
TTK |
0.687 | -0.137 | -2 | 0.777 |
INSRR |
0.687 | 0.044 | 3 | 0.573 |
DDR1 |
0.687 | -0.010 | 4 | 0.417 |
FER |
0.685 | 0.059 | 1 | 0.842 |
SRMS |
0.684 | 0.089 | 1 | 0.832 |
RET |
0.684 | -0.085 | 1 | 0.732 |
FGFR2 |
0.683 | 0.010 | 3 | 0.606 |
EPHB2 |
0.682 | 0.049 | -1 | 0.798 |
EPHB3 |
0.682 | 0.034 | -1 | 0.801 |
LIMK1_TYR |
0.681 | -0.176 | 2 | 0.413 |
TYRO3 |
0.681 | -0.126 | 3 | 0.605 |
TAO1 |
0.680 | -0.151 | 1 | 0.662 |
TYK2 |
0.680 | -0.145 | 1 | 0.730 |
ROS1 |
0.680 | -0.151 | 3 | 0.580 |
JAK3 |
0.679 | -0.092 | 1 | 0.743 |
MYO3B |
0.679 | -0.167 | 2 | 0.362 |
EPHB1 |
0.679 | -0.008 | 1 | 0.821 |
EPHA5 |
0.679 | 0.095 | 2 | 0.454 |
MST1R |
0.678 | -0.172 | 3 | 0.620 |
EPHA7 |
0.678 | 0.038 | 2 | 0.430 |
CSF1R |
0.678 | -0.107 | 3 | 0.602 |
JAK2 |
0.677 | -0.134 | 1 | 0.737 |
YANK2 |
0.677 | -0.051 | 2 | 0.238 |
TNK2 |
0.677 | -0.070 | 3 | 0.592 |
EPHA3 |
0.677 | -0.000 | 2 | 0.416 |
MYO3A |
0.677 | -0.180 | 1 | 0.681 |
CK1A |
0.676 | -0.042 | -3 | 0.418 |
ABL2 |
0.676 | -0.058 | -1 | 0.790 |
YES1 |
0.676 | -0.035 | -1 | 0.799 |
TXK |
0.676 | -0.014 | 1 | 0.820 |
MERTK |
0.676 | -0.010 | 3 | 0.606 |
STLK3 |
0.675 | -0.152 | 1 | 0.692 |
PDGFRB |
0.675 | -0.115 | 3 | 0.605 |
FGFR1 |
0.674 | -0.081 | 3 | 0.591 |
AXL |
0.674 | -0.049 | 3 | 0.600 |
TEK |
0.674 | -0.069 | 3 | 0.557 |
HCK |
0.673 | -0.054 | -1 | 0.785 |
KIT |
0.673 | -0.077 | 3 | 0.598 |
FGFR3 |
0.672 | -0.018 | 3 | 0.589 |
NTRK1 |
0.672 | -0.017 | -1 | 0.807 |
NEK10_TYR |
0.672 | -0.094 | 1 | 0.652 |
FGR |
0.672 | -0.111 | 1 | 0.763 |
FLT3 |
0.672 | -0.112 | 3 | 0.594 |
BLK |
0.672 | -0.023 | -1 | 0.798 |
AAK1 |
0.671 | -0.001 | 1 | 0.534 |
LCK |
0.671 | -0.060 | -1 | 0.791 |
ITK |
0.670 | -0.074 | -1 | 0.762 |
INSR |
0.669 | -0.050 | 3 | 0.554 |
ABL1 |
0.669 | -0.103 | -1 | 0.779 |
PTK2 |
0.669 | 0.037 | -1 | 0.797 |
FYN |
0.668 | 0.021 | -1 | 0.767 |
KDR |
0.668 | -0.137 | 3 | 0.575 |
ALK |
0.668 | -0.097 | 3 | 0.540 |
TNK1 |
0.668 | -0.122 | 3 | 0.586 |
LTK |
0.668 | -0.071 | 3 | 0.557 |
EGFR |
0.668 | 0.025 | 1 | 0.646 |
DDR2 |
0.667 | 0.013 | 3 | 0.559 |
EPHA1 |
0.667 | -0.067 | 3 | 0.585 |
EPHA8 |
0.667 | 0.001 | -1 | 0.788 |
TNNI3K_TYR |
0.665 | -0.155 | 1 | 0.709 |
MET |
0.665 | -0.121 | 3 | 0.603 |
PTK2B |
0.665 | -0.034 | -1 | 0.735 |
BMX |
0.665 | -0.041 | -1 | 0.681 |
JAK1 |
0.665 | -0.142 | 1 | 0.687 |
PDGFRA |
0.665 | -0.193 | 3 | 0.608 |
EPHA2 |
0.664 | 0.032 | -1 | 0.762 |
SYK |
0.664 | 0.061 | -1 | 0.775 |
FLT4 |
0.664 | -0.109 | 3 | 0.574 |
NTRK2 |
0.663 | -0.124 | 3 | 0.588 |
ERBB2 |
0.662 | -0.099 | 1 | 0.716 |
FLT1 |
0.662 | -0.095 | -1 | 0.840 |
TEC |
0.662 | -0.085 | -1 | 0.690 |
IGF1R |
0.662 | -0.004 | 3 | 0.503 |
FGFR4 |
0.660 | -0.000 | -1 | 0.754 |
NTRK3 |
0.660 | -0.056 | -1 | 0.758 |
PTK6 |
0.660 | -0.136 | -1 | 0.694 |
LYN |
0.660 | -0.056 | 3 | 0.535 |
BTK |
0.660 | -0.131 | -1 | 0.722 |
MATK |
0.657 | -0.074 | -1 | 0.732 |
FRK |
0.657 | -0.127 | -1 | 0.804 |
CK1G3 |
0.656 | -0.042 | -3 | 0.372 |
CSK |
0.656 | -0.057 | 2 | 0.417 |
ERBB4 |
0.656 | -0.001 | 1 | 0.670 |
WEE1_TYR |
0.656 | -0.146 | -1 | 0.725 |
SRC |
0.655 | -0.055 | -1 | 0.760 |
CK1G2 |
0.644 | -0.038 | -3 | 0.459 |
FES |
0.640 | -0.072 | -1 | 0.661 |
MUSK |
0.637 | -0.169 | 1 | 0.607 |
ZAP70 |
0.632 | -0.043 | -1 | 0.698 |