Motif 540 (n=75)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| B2RXH8 | HNRNPCL2 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| H3BRN7 | None | S23 | ochoa | Uncharacterized protein | None |
| O00592 | PODXL | S122 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O14490 | DLGAP1 | S169 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O15062 | ZBTB5 | S234 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O43639 | NCK2 | S90 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O60812 | HNRNPCL1 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O75083 | WDR1 | S198 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| O75369 | FLNB | S886 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75526 | RBMXL2 | S58 | ochoa | RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T) | None |
| O95983 | MBD3 | S37 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| P05455 | SSB | S160 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P07910 | HNRNPC | S31 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P0DMR1 | HNRNPCL4 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P11940 | PABPC1 | S342 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P18615 | NELFE | S353 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P18887 | XRCC1 | S151 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19338 | NCL | S356 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19338 | NCL | S619 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20618 | PSMB1 | S68 | ochoa | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P22626 | HNRNPA2B1 | S71 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P28906 | CD34 | S346 | ochoa | Hematopoietic progenitor cell antigen CD34 (CD antigen CD34) | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| P29401 | TKT | S387 | psp | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29558 | RBMS1 | S112 | ochoa | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. |
| P31943 | HNRNPH1 | S63 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P31943 | HNRNPH1 | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P38159 | RBMX | S58 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P51814 | ZNF41 | S269 | ochoa | Zinc finger protein 41 | May be involved in transcriptional regulation. |
| P52272 | HNRNPM | S701 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52597 | HNRNPF | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P55201 | BRPF1 | S1081 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55795 | HNRNPH2 | S63 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P55795 | HNRNPH2 | S161 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P55884 | EIF3B | S239 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P62263 | RPS14 | S70 | ochoa | Small ribosomal subunit protein uS11 (40S ribosomal protein S14) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q03164 | KMT2A | S2361 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q13310 | PABPC4 | S342 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q14678 | KANK1 | S641 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q15434 | RBMS2 | S106 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q15700 | DLG2 | S65 | ochoa | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}. |
| Q17RY0 | CPEB4 | S332 | ochoa | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}. |
| Q2VPB7 | AP5B1 | S216 | ochoa | AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}. |
| Q49A88 | CCDC14 | S374 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q4VXU2 | PABPC1L | S342 | ochoa | Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like) | Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250|UniProtKB:A2A5N3, ECO:0000269|PubMed:37052235, ECO:0000269|PubMed:37723834}. |
| Q5JSZ5 | PRRC2B | S853 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q6XE24 | RBMS3 | S111 | ochoa | RNA-binding motif, single-stranded-interacting protein 3 | Binds poly(A) and poly(U) oligoribonucleotides. {ECO:0000269|PubMed:10675610}. |
| Q7Z698 | SPRED2 | S104 | ochoa | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}. |
| Q7Z699 | SPRED1 | S105 | ochoa|psp | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
| Q8IXJ9 | ASXL1 | S1166 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8N7X1 | RBMXL3 | S58 | ochoa | RNA-binding motif protein, X-linked-like-3 | None |
| Q8TF40 | FNIP1 | S214 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q92945 | KHSRP | S480 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96E39 | RBMXL1 | S58 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q9BTW9 | TBCD | S805 | ochoa | Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) | Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374). {ECO:0000269|PubMed:10722852, ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:20740604, ECO:0000269|PubMed:27666370, ECO:0000269|PubMed:27666374, ECO:0000269|PubMed:28158450}. |
| Q9BXB5 | OSBPL10 | S223 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BZ95 | NSD3 | S107 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9GZT3 | SLIRP | S69 | ochoa | SRA stem-loop-interacting RNA-binding protein, mitochondrial | RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269|PubMed:16762838}. |
| Q9H0H5 | RACGAP1 | S359 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H361 | PABPC3 | S342 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9NTZ6 | RBM12 | S352 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9P2D1 | CHD7 | S2356 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2K5 | MYEF2 | S571 | ochoa | Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) | Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}. |
| Q9UBB5 | MBD2 | S181 | ochoa | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Q9UHC6 | CNTNAP2 | S1303 | ochoa | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}. |
| Q9UHQ9 | CYB5R1 | S169 | ochoa | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}. |
| Q9UIS9 | MBD1 | S37 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UKL3 | CASP8AP2 | S20 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| P19338 | NCL | S532 | Sugiyama | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P04843 | RPN1 | S385 | Sugiyama | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P52597 | HNRNPF | S63 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| O00468 | AGRN | S641 | Sugiyama | Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] | [Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.; FUNCTION: [Isoform 2]: Transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.; FUNCTION: Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.; FUNCTION: Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.; FUNCTION: [Agrin N-terminal 110 kDa subunit]: Is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19631309, ECO:0000269|PubMed:21969364}.; FUNCTION: [Agrin C-terminal 22 kDa fragment]: This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia. |
| Q6EMK4 | VASN | S322 | Sugiyama | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q12849 | GRSF1 | S202 | Sugiyama | G-rich sequence factor 1 (GRSF-1) | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8953854 | Metabolism of RNA | 0.000006 | 5.233 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.000054 | 4.269 |
| R-HSA-72172 | mRNA Splicing | 0.000074 | 4.133 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.000150 | 3.823 |
| R-HSA-190236 | Signaling by FGFR | 0.000146 | 3.837 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.000299 | 3.525 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000358 | 3.446 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000425 | 3.372 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.000505 | 3.297 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000605 | 3.218 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.000800 | 3.097 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.001030 | 2.987 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000991 | 3.004 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.001906 | 2.720 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.002182 | 2.661 |
| R-HSA-72649 | Translation initiation complex formation | 0.002903 | 2.537 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.003457 | 2.461 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.003441 | 2.463 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.003395 | 2.469 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.031242 | 1.505 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.034461 | 1.463 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.012453 | 1.905 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.031242 | 1.505 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.021524 | 1.667 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.021524 | 1.667 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.017972 | 1.745 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.012453 | 1.905 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.025251 | 1.598 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.030639 | 1.514 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.033698 | 1.472 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.008355 | 2.078 |
| R-HSA-5689603 | UCH proteinases | 0.006727 | 2.172 |
| R-HSA-9907900 | Proteasome assembly | 0.023550 | 1.628 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.013097 | 1.883 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.015815 | 1.801 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.015815 | 1.801 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.021094 | 1.676 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.021094 | 1.676 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.025251 | 1.598 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.026119 | 1.583 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.030639 | 1.514 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.031577 | 1.501 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.008614 | 2.065 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.017477 | 1.758 |
| R-HSA-9909396 | Circadian clock | 0.029994 | 1.523 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.013755 | 1.862 |
| R-HSA-4641258 | Degradation of DVL | 0.017256 | 1.763 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.020300 | 1.693 |
| R-HSA-72766 | Translation | 0.016471 | 1.783 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.016529 | 1.782 |
| R-HSA-4641257 | Degradation of AXIN | 0.017256 | 1.763 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.017256 | 1.763 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.030639 | 1.514 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.032527 | 1.488 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.014428 | 1.841 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.015114 | 1.821 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.015114 | 1.821 |
| R-HSA-169911 | Regulation of Apoptosis | 0.015815 | 1.801 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.021094 | 1.676 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.021094 | 1.676 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.030639 | 1.514 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.019519 | 1.710 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.020300 | 1.693 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.020300 | 1.693 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.031577 | 1.501 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.009129 | 2.040 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.033489 | 1.475 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.007586 | 2.120 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.018752 | 1.727 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.018752 | 1.727 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.022719 | 1.644 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.023550 | 1.628 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.024394 | 1.613 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.034461 | 1.463 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.024394 | 1.613 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.011264 | 1.948 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.017723 | 1.751 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.019519 | 1.710 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.020300 | 1.693 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.024394 | 1.613 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.028532 | 1.545 |
| R-HSA-9766229 | Degradation of CDH1 | 0.027892 | 1.555 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.029711 | 1.527 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.024394 | 1.613 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.024394 | 1.613 |
| R-HSA-4839726 | Chromatin organization | 0.034144 | 1.467 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.029711 | 1.527 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.013301 | 1.876 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.031577 | 1.501 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.014523 | 1.838 |
| R-HSA-69541 | Stabilization of p53 | 0.018752 | 1.727 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.029711 | 1.527 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.007636 | 2.117 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.025747 | 1.589 |
| R-HSA-6807070 | PTEN Regulation | 0.034246 | 1.465 |
| R-HSA-9824272 | Somitogenesis | 0.024394 | 1.613 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.027892 | 1.555 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.027892 | 1.555 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.007434 | 2.129 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.034461 | 1.463 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.035444 | 1.450 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.036969 | 1.432 |
| R-HSA-351202 | Metabolism of polyamines | 0.038458 | 1.415 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.039484 | 1.404 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.039484 | 1.404 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.040520 | 1.392 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.040520 | 1.392 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.041567 | 1.381 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.042118 | 1.376 |
| R-HSA-422475 | Axon guidance | 0.043478 | 1.362 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.043690 | 1.360 |
| R-HSA-428540 | Activation of RAC1 | 0.065769 | 1.182 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.065769 | 1.182 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.044334 | 1.353 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.052966 | 1.276 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.052572 | 1.279 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.056056 | 1.251 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.050295 | 1.298 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.050295 | 1.298 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.058422 | 1.233 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.054886 | 1.261 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.064487 | 1.191 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.049170 | 1.308 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.050295 | 1.298 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.051429 | 1.289 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.049170 | 1.308 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.053724 | 1.270 |
| R-HSA-9675108 | Nervous system development | 0.055898 | 1.253 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.049170 | 1.308 |
| R-HSA-5619084 | ABC transporter disorders | 0.058422 | 1.233 |
| R-HSA-4086400 | PCP/CE pathway | 0.058422 | 1.233 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.056992 | 1.244 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.056992 | 1.244 |
| R-HSA-1500931 | Cell-Cell communication | 0.066580 | 1.177 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.066970 | 1.174 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.066970 | 1.174 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.066970 | 1.174 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.067815 | 1.169 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.069999 | 1.155 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.069999 | 1.155 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.069999 | 1.155 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.086729 | 1.062 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.090865 | 1.042 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.090865 | 1.042 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.094983 | 1.022 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.103163 | 0.986 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.115296 | 0.938 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.115296 | 0.938 |
| R-HSA-429947 | Deadenylation of mRNA | 0.127268 | 0.895 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.139079 | 0.857 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.139079 | 0.857 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.077210 | 1.112 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.083846 | 1.077 |
| R-HSA-192823 | Viral mRNA Translation | 0.094808 | 1.023 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.101858 | 0.992 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.103286 | 0.986 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.109050 | 0.962 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.109050 | 0.962 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.135160 | 0.869 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.090865 | 1.042 |
| R-HSA-3928664 | Ephrin signaling | 0.099082 | 1.004 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.107225 | 0.970 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.090865 | 1.042 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.099082 | 1.004 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.115296 | 0.938 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.139079 | 0.857 |
| R-HSA-9694614 | Attachment and Entry | 0.115296 | 0.938 |
| R-HSA-9620244 | Long-term potentiation | 0.131223 | 0.882 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.074209 | 1.130 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.115296 | 0.938 |
| R-HSA-114608 | Platelet degranulation | 0.135963 | 0.867 |
| R-HSA-162906 | HIV Infection | 0.102186 | 0.991 |
| R-HSA-373753 | Nephrin family interactions | 0.107225 | 0.970 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.083846 | 1.077 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.111270 | 0.954 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.101264 | 0.995 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.103163 | 0.986 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.123295 | 0.909 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.131223 | 0.882 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.090650 | 1.043 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.073314 | 1.135 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.115296 | 0.938 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.103286 | 0.986 |
| R-HSA-69239 | Synthesis of DNA | 0.101858 | 0.992 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.103163 | 0.986 |
| R-HSA-5688426 | Deubiquitination | 0.129323 | 0.888 |
| R-HSA-9824446 | Viral Infection Pathways | 0.074668 | 1.127 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.085193 | 1.070 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.079843 | 1.098 |
| R-HSA-202424 | Downstream TCR signaling | 0.074605 | 1.127 |
| R-HSA-69481 | G2/M Checkpoints | 0.135963 | 0.867 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.090650 | 1.043 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.122320 | 0.913 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.129857 | 0.887 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.104719 | 0.980 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.086548 | 1.063 |
| R-HSA-202403 | TCR signaling | 0.106157 | 0.974 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.092030 | 1.036 |
| R-HSA-69206 | G1/S Transition | 0.132901 | 0.876 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.074459 | 1.128 |
| R-HSA-418990 | Adherens junctions interactions | 0.094011 | 1.027 |
| R-HSA-421270 | Cell-cell junction organization | 0.125298 | 0.902 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.096226 | 1.017 |
| R-HSA-449147 | Signaling by Interleukins | 0.072801 | 1.138 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.142981 | 0.845 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.142981 | 0.845 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.142981 | 0.845 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.142981 | 0.845 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.142981 | 0.845 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.146799 | 0.833 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.153070 | 0.815 |
| R-HSA-446728 | Cell junction organization | 0.153323 | 0.814 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.154583 | 0.811 |
| R-HSA-186763 | Downstream signal transduction | 0.154583 | 0.811 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.154647 | 0.811 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.156226 | 0.806 |
| R-HSA-2024096 | HS-GAG degradation | 0.158416 | 0.800 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.162232 | 0.790 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.166030 | 0.780 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.167367 | 0.776 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.169812 | 0.770 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.169812 | 0.770 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.170576 | 0.768 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.171909 | 0.765 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.173577 | 0.761 |
| R-HSA-381042 | PERK regulates gene expression | 0.173577 | 0.761 |
| R-HSA-69242 | S Phase | 0.173795 | 0.760 |
| R-HSA-9758941 | Gastrulation | 0.175409 | 0.756 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.177324 | 0.751 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.177324 | 0.751 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.177324 | 0.751 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.180264 | 0.744 |
| R-HSA-419037 | NCAM1 interactions | 0.181055 | 0.742 |
| R-HSA-69306 | DNA Replication | 0.181887 | 0.740 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.185140 | 0.732 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.188468 | 0.725 |
| R-HSA-71336 | Pentose phosphate pathway | 0.188468 | 0.725 |
| R-HSA-9711097 | Cellular response to starvation | 0.190035 | 0.721 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.190035 | 0.721 |
| R-HSA-2262752 | Cellular responses to stress | 0.190764 | 0.720 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.192149 | 0.716 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.192149 | 0.716 |
| R-HSA-167169 | HIV Transcription Elongation | 0.192149 | 0.716 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.192149 | 0.716 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.192149 | 0.716 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.192149 | 0.716 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.193309 | 0.714 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.195814 | 0.708 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.195814 | 0.708 |
| R-HSA-9694548 | Maturation of spike protein | 0.195814 | 0.708 |
| R-HSA-109581 | Apoptosis | 0.196590 | 0.706 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.199462 | 0.700 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.199879 | 0.699 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.203094 | 0.692 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.203820 | 0.691 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.211440 | 0.675 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.213097 | 0.671 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.213893 | 0.670 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.216416 | 0.665 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.226221 | 0.645 |
| R-HSA-168255 | Influenza Infection | 0.226401 | 0.645 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.227121 | 0.644 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.233077 | 0.633 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.234597 | 0.630 |
| R-HSA-69275 | G2/M Transition | 0.238093 | 0.623 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.238532 | 0.622 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.241441 | 0.617 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.241441 | 0.617 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.241989 | 0.616 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.241989 | 0.616 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.245431 | 0.610 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.248857 | 0.604 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.252268 | 0.598 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.259044 | 0.587 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.262409 | 0.581 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.262409 | 0.581 |
| R-HSA-9679506 | SARS-CoV Infections | 0.264850 | 0.577 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.265759 | 0.576 |
| R-HSA-983189 | Kinesins | 0.265759 | 0.576 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.265759 | 0.576 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.266605 | 0.574 |
| R-HSA-5357801 | Programmed Cell Death | 0.271643 | 0.566 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.272415 | 0.565 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.272415 | 0.565 |
| R-HSA-186797 | Signaling by PDGF | 0.272415 | 0.565 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.275720 | 0.560 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.276421 | 0.558 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.285547 | 0.544 |
| R-HSA-68882 | Mitotic Anaphase | 0.290106 | 0.537 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.291782 | 0.535 |
| R-HSA-167172 | Transcription of the HIV genome | 0.292026 | 0.535 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.292026 | 0.535 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.298446 | 0.525 |
| R-HSA-8951664 | Neddylation | 0.298485 | 0.525 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.301635 | 0.521 |
| R-HSA-3000178 | ECM proteoglycans | 0.301635 | 0.521 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.301635 | 0.521 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.301635 | 0.521 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.311116 | 0.507 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.314247 | 0.503 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.314247 | 0.503 |
| R-HSA-72312 | rRNA processing | 0.316865 | 0.499 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.320469 | 0.494 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.323559 | 0.490 |
| R-HSA-216083 | Integrin cell surface interactions | 0.323559 | 0.490 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.329697 | 0.482 |
| R-HSA-157118 | Signaling by NOTCH | 0.330170 | 0.481 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.332746 | 0.478 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.341757 | 0.466 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.341810 | 0.466 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.353706 | 0.451 |
| R-HSA-1280218 | Adaptive Immune System | 0.354407 | 0.450 |
| R-HSA-156902 | Peptide chain elongation | 0.356647 | 0.448 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.359841 | 0.444 |
| R-HSA-73884 | Base Excision Repair | 0.362489 | 0.441 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.365390 | 0.437 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.371154 | 0.430 |
| R-HSA-391251 | Protein folding | 0.371154 | 0.430 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.371154 | 0.430 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.371154 | 0.430 |
| R-HSA-5663205 | Infectious disease | 0.372064 | 0.429 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.378964 | 0.421 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.379703 | 0.421 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.382527 | 0.417 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.385339 | 0.414 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.385825 | 0.414 |
| R-HSA-3214847 | HATs acetylate histones | 0.393697 | 0.405 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.398653 | 0.399 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.399207 | 0.399 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.401944 | 0.396 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.401944 | 0.396 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.407380 | 0.390 |
| R-HSA-9833110 | RSV-host interactions | 0.410080 | 0.387 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.412767 | 0.384 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.415443 | 0.381 |
| R-HSA-195721 | Signaling by WNT | 0.423940 | 0.373 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.444092 | 0.353 |
| R-HSA-5693538 | Homology Directed Repair | 0.451662 | 0.345 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.464054 | 0.333 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.464054 | 0.333 |
| R-HSA-194138 | Signaling by VEGF | 0.471356 | 0.327 |
| R-HSA-1474244 | Extracellular matrix organization | 0.474331 | 0.324 |
| R-HSA-9843745 | Adipogenesis | 0.488014 | 0.312 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.490351 | 0.309 |
| R-HSA-163685 | Integration of energy metabolism | 0.501880 | 0.299 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.501880 | 0.299 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.508673 | 0.294 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.517589 | 0.286 |
| R-HSA-162582 | Signal Transduction | 0.525932 | 0.279 |
| R-HSA-2187338 | Visual phototransduction | 0.528509 | 0.277 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.534944 | 0.272 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.541292 | 0.267 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.543390 | 0.265 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.543390 | 0.265 |
| R-HSA-68886 | M Phase | 0.548208 | 0.261 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.549558 | 0.260 |
| R-HSA-162587 | HIV Life Cycle | 0.549624 | 0.260 |
| R-HSA-392499 | Metabolism of proteins | 0.552043 | 0.258 |
| R-HSA-74160 | Gene expression (Transcription) | 0.556087 | 0.255 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.557503 | 0.254 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.563847 | 0.249 |
| R-HSA-212436 | Generic Transcription Pathway | 0.578159 | 0.238 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.587205 | 0.231 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.587205 | 0.231 |
| R-HSA-3781865 | Diseases of glycosylation | 0.603910 | 0.219 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.619947 | 0.208 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.631977 | 0.199 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.637017 | 0.196 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.639369 | 0.194 |
| R-HSA-6798695 | Neutrophil degranulation | 0.641656 | 0.193 |
| R-HSA-597592 | Post-translational protein modification | 0.649484 | 0.187 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.653329 | 0.185 |
| R-HSA-112316 | Neuronal System | 0.654033 | 0.184 |
| R-HSA-1643685 | Disease | 0.660237 | 0.180 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.671296 | 0.173 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.677938 | 0.169 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.679417 | 0.168 |
| R-HSA-1266738 | Developmental Biology | 0.681875 | 0.166 |
| R-HSA-8939211 | ESR-mediated signaling | 0.691014 | 0.161 |
| R-HSA-109582 | Hemostasis | 0.713203 | 0.147 |
| R-HSA-168256 | Immune System | 0.741750 | 0.130 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.749899 | 0.125 |
| R-HSA-1483257 | Phospholipid metabolism | 0.763580 | 0.117 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.792314 | 0.101 |
| R-HSA-73894 | DNA Repair | 0.825060 | 0.084 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.827480 | 0.082 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.828279 | 0.082 |
| R-HSA-382551 | Transport of small molecules | 0.839998 | 0.076 |
| R-HSA-913531 | Interferon Signaling | 0.843520 | 0.074 |
| R-HSA-1640170 | Cell Cycle | 0.848391 | 0.071 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.869502 | 0.061 |
| R-HSA-5668914 | Diseases of metabolism | 0.872509 | 0.059 |
| R-HSA-199991 | Membrane Trafficking | 0.954842 | 0.020 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.978896 | 0.009 |
| R-HSA-168249 | Innate Immune System | 0.987134 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 0.997363 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999240 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999815 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.716 | 0.391 | 1 | 0.807 |
CDK8 |
0.709 | 0.441 | 1 | 0.790 |
P38D |
0.709 | 0.479 | 1 | 0.853 |
CDK19 |
0.706 | 0.432 | 1 | 0.800 |
JNK2 |
0.705 | 0.481 | 1 | 0.820 |
JNK3 |
0.704 | 0.484 | 1 | 0.826 |
P38B |
0.703 | 0.454 | 1 | 0.813 |
FAM20C |
0.702 | 0.171 | 2 | 0.765 |
CDK3 |
0.702 | 0.401 | 1 | 0.824 |
CDK1 |
0.700 | 0.424 | 1 | 0.806 |
CDK18 |
0.700 | 0.431 | 1 | 0.813 |
CDK7 |
0.700 | 0.415 | 1 | 0.811 |
CDK13 |
0.700 | 0.431 | 1 | 0.819 |
CDK17 |
0.699 | 0.445 | 1 | 0.816 |
DYRK2 |
0.699 | 0.390 | 1 | 0.766 |
P38G |
0.699 | 0.465 | 1 | 0.819 |
CLK3 |
0.698 | 0.216 | 1 | 0.652 |
CDK5 |
0.697 | 0.407 | 1 | 0.792 |
CDK9 |
0.694 | 0.430 | 1 | 0.813 |
HIPK4 |
0.694 | 0.228 | 1 | 0.627 |
CDK12 |
0.693 | 0.426 | 1 | 0.824 |
NLK |
0.693 | 0.330 | 1 | 0.645 |
CDK2 |
0.693 | 0.335 | 1 | 0.731 |
DYRK4 |
0.692 | 0.403 | 1 | 0.819 |
ERK1 |
0.692 | 0.427 | 1 | 0.813 |
CDC7 |
0.691 | -0.023 | 1 | 0.452 |
P38A |
0.690 | 0.410 | 1 | 0.771 |
JNK1 |
0.689 | 0.431 | 1 | 0.824 |
ERK5 |
0.689 | 0.187 | 1 | 0.591 |
HIPK2 |
0.688 | 0.377 | 1 | 0.798 |
CAMK2G |
0.687 | 0.016 | 2 | 0.740 |
MTOR |
0.687 | 0.049 | 1 | 0.468 |
IKKB |
0.686 | -0.042 | -2 | 0.713 |
CDK16 |
0.685 | 0.405 | 1 | 0.817 |
MOS |
0.685 | -0.017 | 1 | 0.476 |
SRPK1 |
0.685 | 0.146 | -3 | 0.662 |
ERK2 |
0.685 | 0.415 | 1 | 0.787 |
CAMK1B |
0.683 | 0.005 | -3 | 0.769 |
PDHK4 |
0.683 | -0.071 | 1 | 0.406 |
CDK14 |
0.682 | 0.401 | 1 | 0.785 |
COT |
0.681 | -0.141 | 2 | 0.742 |
ATR |
0.681 | -0.017 | 1 | 0.418 |
SRPK2 |
0.680 | 0.115 | -3 | 0.609 |
PDHK1 |
0.679 | -0.074 | 1 | 0.378 |
PRPK |
0.679 | -0.114 | -1 | 0.767 |
DYRK1B |
0.678 | 0.362 | 1 | 0.787 |
DYRK1A |
0.678 | 0.298 | 1 | 0.762 |
CDK10 |
0.677 | 0.373 | 1 | 0.797 |
CDKL5 |
0.677 | 0.055 | -3 | 0.711 |
ICK |
0.677 | 0.146 | -3 | 0.743 |
CAMK2D |
0.677 | -0.000 | -3 | 0.742 |
CK2A2 |
0.677 | 0.116 | 1 | 0.378 |
HIPK3 |
0.677 | 0.338 | 1 | 0.733 |
GRK1 |
0.677 | 0.000 | -2 | 0.678 |
ATM |
0.676 | -0.006 | 1 | 0.394 |
MARK4 |
0.676 | -0.030 | 4 | 0.632 |
CDKL1 |
0.676 | 0.039 | -3 | 0.722 |
GRK5 |
0.675 | -0.045 | -3 | 0.773 |
CDK4 |
0.675 | 0.412 | 1 | 0.822 |
PRKD1 |
0.675 | -0.026 | -3 | 0.719 |
GRK6 |
0.674 | -0.015 | 1 | 0.364 |
BCKDK |
0.674 | -0.061 | -1 | 0.751 |
HIPK1 |
0.674 | 0.325 | 1 | 0.747 |
CHK1 |
0.674 | 0.064 | -3 | 0.732 |
IKKA |
0.674 | -0.042 | -2 | 0.670 |
IKKE |
0.673 | -0.116 | 1 | 0.276 |
CDK6 |
0.673 | 0.391 | 1 | 0.799 |
TBK1 |
0.673 | -0.140 | 1 | 0.280 |
PIM3 |
0.673 | -0.068 | -3 | 0.739 |
CLK4 |
0.673 | 0.170 | -3 | 0.672 |
CAMK2B |
0.672 | 0.015 | 2 | 0.737 |
MAPKAPK3 |
0.672 | -0.010 | -3 | 0.672 |
MAPKAPK2 |
0.672 | -0.001 | -3 | 0.643 |
BMPR2 |
0.672 | -0.165 | -2 | 0.687 |
DYRK3 |
0.672 | 0.268 | 1 | 0.721 |
CLK1 |
0.672 | 0.191 | -3 | 0.651 |
PKN3 |
0.670 | -0.061 | -3 | 0.730 |
CAMK2A |
0.670 | 0.013 | 2 | 0.725 |
TSSK2 |
0.670 | -0.032 | -5 | 0.740 |
DSTYK |
0.670 | -0.132 | 2 | 0.748 |
DNAPK |
0.669 | 0.017 | 1 | 0.368 |
RAF1 |
0.669 | -0.211 | 1 | 0.345 |
GCN2 |
0.669 | -0.190 | 2 | 0.624 |
AMPKA1 |
0.667 | -0.069 | -3 | 0.734 |
CLK2 |
0.667 | 0.172 | -3 | 0.660 |
CK2A1 |
0.666 | 0.086 | 1 | 0.361 |
SRPK3 |
0.666 | 0.083 | -3 | 0.651 |
PRKD2 |
0.666 | -0.033 | -3 | 0.660 |
ULK2 |
0.666 | -0.200 | 2 | 0.624 |
MARK2 |
0.666 | -0.010 | 4 | 0.584 |
RSK2 |
0.665 | -0.038 | -3 | 0.691 |
CAMLCK |
0.665 | -0.048 | -2 | 0.707 |
PAK6 |
0.665 | 0.005 | -2 | 0.646 |
NIK |
0.665 | -0.119 | -3 | 0.782 |
PRP4 |
0.665 | 0.206 | -3 | 0.638 |
DAPK2 |
0.664 | -0.073 | -3 | 0.770 |
WNK1 |
0.664 | -0.097 | -2 | 0.710 |
TGFBR1 |
0.664 | -0.019 | -2 | 0.561 |
MASTL |
0.664 | -0.121 | -2 | 0.726 |
QIK |
0.664 | -0.049 | -3 | 0.728 |
NUAK2 |
0.664 | -0.044 | -3 | 0.719 |
PIM1 |
0.664 | -0.029 | -3 | 0.684 |
TSSK1 |
0.663 | -0.044 | -3 | 0.752 |
AMPKA2 |
0.663 | -0.059 | -3 | 0.706 |
MEK1 |
0.662 | 0.014 | 2 | 0.679 |
NDR2 |
0.662 | -0.117 | -3 | 0.735 |
SMG1 |
0.662 | -0.034 | 1 | 0.389 |
CAMK4 |
0.661 | -0.070 | -3 | 0.717 |
MST4 |
0.661 | -0.093 | 2 | 0.628 |
NIM1 |
0.661 | -0.080 | 3 | 0.563 |
CHAK2 |
0.661 | -0.094 | -1 | 0.785 |
QSK |
0.661 | -0.041 | 4 | 0.624 |
NEK6 |
0.661 | -0.160 | -2 | 0.654 |
MARK3 |
0.660 | -0.025 | 4 | 0.591 |
MARK1 |
0.660 | -0.015 | 4 | 0.598 |
HUNK |
0.660 | -0.145 | 2 | 0.668 |
SKMLCK |
0.660 | -0.098 | -2 | 0.679 |
PKACG |
0.660 | -0.056 | -2 | 0.694 |
RSK3 |
0.660 | -0.052 | -3 | 0.686 |
P90RSK |
0.660 | -0.055 | -3 | 0.688 |
BMPR1B |
0.659 | -0.041 | 1 | 0.362 |
ULK1 |
0.659 | -0.178 | -3 | 0.707 |
P70S6KB |
0.658 | -0.061 | -3 | 0.707 |
PKN2 |
0.658 | -0.106 | -3 | 0.722 |
SIK |
0.658 | -0.047 | -3 | 0.666 |
WNK3 |
0.658 | -0.200 | 1 | 0.328 |
PRKD3 |
0.658 | -0.031 | -3 | 0.645 |
LATS2 |
0.657 | -0.084 | -5 | 0.604 |
ALK4 |
0.657 | -0.062 | -2 | 0.597 |
PLK3 |
0.657 | -0.043 | 2 | 0.693 |
GRK7 |
0.657 | -0.017 | 1 | 0.361 |
NEK7 |
0.656 | -0.229 | -3 | 0.729 |
LATS1 |
0.656 | -0.030 | -3 | 0.762 |
SBK |
0.656 | 0.097 | -3 | 0.502 |
GRK4 |
0.656 | -0.136 | -2 | 0.621 |
NDR1 |
0.656 | -0.130 | -3 | 0.736 |
PINK1 |
0.655 | 0.028 | 1 | 0.488 |
MELK |
0.655 | -0.082 | -3 | 0.702 |
TGFBR2 |
0.655 | -0.153 | -2 | 0.560 |
NUAK1 |
0.655 | -0.065 | -3 | 0.694 |
MLK1 |
0.654 | -0.178 | 2 | 0.632 |
PKCD |
0.654 | -0.102 | 2 | 0.618 |
MNK2 |
0.654 | -0.075 | -2 | 0.676 |
ERK7 |
0.653 | 0.108 | 2 | 0.387 |
ANKRD3 |
0.653 | -0.192 | 1 | 0.356 |
MAK |
0.653 | 0.226 | -2 | 0.520 |
MLK2 |
0.652 | -0.151 | 2 | 0.636 |
ALK2 |
0.652 | -0.041 | -2 | 0.576 |
RIPK3 |
0.652 | -0.200 | 3 | 0.475 |
ACVR2B |
0.652 | -0.073 | -2 | 0.575 |
MSK2 |
0.651 | -0.065 | -3 | 0.656 |
MAPKAPK5 |
0.651 | -0.072 | -3 | 0.644 |
ACVR2A |
0.650 | -0.083 | -2 | 0.564 |
PLK1 |
0.650 | -0.131 | -2 | 0.604 |
TTBK2 |
0.650 | -0.170 | 2 | 0.597 |
BRSK1 |
0.649 | -0.070 | -3 | 0.690 |
PAK3 |
0.649 | -0.109 | -2 | 0.666 |
BMPR1A |
0.649 | -0.032 | 1 | 0.362 |
IRE1 |
0.649 | -0.160 | 1 | 0.309 |
VRK2 |
0.649 | -0.105 | 1 | 0.437 |
AURC |
0.648 | -0.055 | -2 | 0.588 |
DLK |
0.648 | -0.251 | 1 | 0.339 |
YSK4 |
0.648 | -0.124 | 1 | 0.288 |
SGK3 |
0.648 | -0.033 | -3 | 0.656 |
MYLK4 |
0.648 | -0.057 | -2 | 0.655 |
NEK2 |
0.648 | -0.120 | 2 | 0.617 |
MSK1 |
0.647 | -0.050 | -3 | 0.655 |
GSK3A |
0.647 | 0.049 | 4 | 0.220 |
PKG2 |
0.647 | -0.043 | -2 | 0.637 |
RIPK1 |
0.647 | -0.207 | 1 | 0.316 |
BRSK2 |
0.646 | -0.107 | -3 | 0.712 |
SSTK |
0.646 | -0.073 | 4 | 0.612 |
MOK |
0.646 | 0.195 | 1 | 0.673 |
PAK1 |
0.645 | -0.101 | -2 | 0.649 |
NEK9 |
0.645 | -0.234 | 2 | 0.642 |
CAMK1D |
0.645 | -0.023 | -3 | 0.606 |
TLK1 |
0.645 | -0.092 | -2 | 0.584 |
IRE2 |
0.645 | -0.161 | 2 | 0.603 |
CAMK1G |
0.645 | -0.075 | -3 | 0.677 |
AKT2 |
0.644 | -0.031 | -3 | 0.599 |
PKCZ |
0.644 | -0.111 | 2 | 0.599 |
PKR |
0.644 | -0.152 | 1 | 0.353 |
PHKG1 |
0.643 | -0.124 | -3 | 0.721 |
SNRK |
0.643 | -0.144 | 2 | 0.541 |
PIM2 |
0.643 | -0.039 | -3 | 0.659 |
GRK2 |
0.643 | -0.083 | -2 | 0.563 |
TLK2 |
0.643 | -0.144 | 1 | 0.311 |
PKCG |
0.643 | -0.113 | 2 | 0.581 |
PKACB |
0.642 | -0.047 | -2 | 0.615 |
PRKX |
0.642 | -0.023 | -3 | 0.572 |
BRAF |
0.642 | -0.132 | -4 | 0.516 |
RSK4 |
0.642 | -0.059 | -3 | 0.658 |
PLK4 |
0.641 | -0.133 | 2 | 0.518 |
PKCB |
0.641 | -0.109 | 2 | 0.568 |
PKCA |
0.641 | -0.097 | 2 | 0.547 |
AURA |
0.641 | -0.057 | -2 | 0.541 |
TTBK1 |
0.640 | -0.095 | 2 | 0.552 |
PKCH |
0.640 | -0.112 | 2 | 0.556 |
AURB |
0.640 | -0.069 | -2 | 0.591 |
MLK3 |
0.640 | -0.155 | 2 | 0.576 |
PAK2 |
0.639 | -0.123 | -2 | 0.654 |
PAK5 |
0.639 | -0.058 | -2 | 0.611 |
SMMLCK |
0.639 | -0.056 | -3 | 0.729 |
DRAK1 |
0.639 | -0.158 | 1 | 0.310 |
MNK1 |
0.639 | -0.104 | -2 | 0.679 |
DCAMKL2 |
0.639 | -0.063 | -3 | 0.701 |
PKCI |
0.638 | -0.061 | 2 | 0.561 |
GSK3B |
0.637 | -0.035 | 4 | 0.217 |
PHKG2 |
0.637 | -0.114 | -3 | 0.691 |
MEK5 |
0.637 | -0.165 | 2 | 0.645 |
CAMKK2 |
0.636 | -0.078 | -2 | 0.743 |
PKACA |
0.636 | -0.032 | -2 | 0.591 |
PAK4 |
0.636 | -0.050 | -2 | 0.590 |
PERK |
0.636 | -0.159 | -2 | 0.648 |
PKN1 |
0.636 | -0.043 | -3 | 0.634 |
CAMK1A |
0.636 | -0.018 | -3 | 0.569 |
HRI |
0.636 | -0.186 | -2 | 0.650 |
WNK4 |
0.636 | -0.145 | -2 | 0.705 |
CHAK1 |
0.635 | -0.209 | 2 | 0.594 |
DCAMKL1 |
0.635 | -0.103 | -3 | 0.671 |
PLK2 |
0.634 | -0.024 | -3 | 0.776 |
P70S6K |
0.634 | -0.064 | -3 | 0.630 |
CAMKK1 |
0.634 | -0.121 | -2 | 0.721 |
PKCT |
0.633 | -0.108 | 2 | 0.557 |
MEKK3 |
0.633 | -0.187 | 1 | 0.310 |
MPSK1 |
0.631 | -0.067 | 1 | 0.340 |
PDK1 |
0.631 | -0.074 | 1 | 0.378 |
GRK3 |
0.631 | -0.082 | -2 | 0.517 |
AKT1 |
0.631 | -0.050 | -3 | 0.607 |
MEKK2 |
0.630 | -0.172 | 2 | 0.633 |
ZAK |
0.630 | -0.202 | 1 | 0.295 |
MST2 |
0.630 | -0.091 | 1 | 0.311 |
MLK4 |
0.630 | -0.195 | 2 | 0.554 |
IRAK4 |
0.628 | -0.190 | 1 | 0.306 |
IRAK1 |
0.628 | -0.175 | -1 | 0.675 |
CK1E |
0.628 | -0.086 | -3 | 0.435 |
PKCE |
0.628 | -0.062 | 2 | 0.560 |
PASK |
0.627 | -0.113 | -3 | 0.743 |
GAK |
0.627 | -0.088 | 1 | 0.370 |
TAO3 |
0.627 | -0.151 | 1 | 0.335 |
MEKK1 |
0.626 | -0.241 | 1 | 0.326 |
TAO2 |
0.626 | -0.130 | 2 | 0.672 |
LKB1 |
0.626 | -0.134 | -3 | 0.717 |
LRRK2 |
0.626 | -0.057 | 2 | 0.666 |
MST3 |
0.625 | -0.144 | 2 | 0.634 |
DAPK3 |
0.624 | -0.078 | -3 | 0.696 |
CK1D |
0.624 | -0.068 | -3 | 0.383 |
SGK1 |
0.624 | -0.017 | -3 | 0.535 |
PBK |
0.624 | -0.052 | 1 | 0.340 |
MEK2 |
0.623 | -0.103 | 2 | 0.635 |
SLK |
0.623 | -0.054 | -2 | 0.766 |
LOK |
0.623 | -0.074 | -2 | 0.787 |
CHK2 |
0.622 | -0.039 | -3 | 0.551 |
NEK5 |
0.622 | -0.253 | 1 | 0.328 |
NEK11 |
0.622 | -0.188 | 1 | 0.326 |
NEK8 |
0.621 | -0.231 | 2 | 0.637 |
HGK |
0.621 | -0.111 | 3 | 0.586 |
DAPK1 |
0.621 | -0.075 | -3 | 0.677 |
EEF2K |
0.621 | -0.123 | 3 | 0.593 |
PKG1 |
0.620 | -0.045 | -2 | 0.590 |
AKT3 |
0.620 | -0.046 | -3 | 0.540 |
MINK |
0.620 | -0.125 | 1 | 0.280 |
TNIK |
0.619 | -0.102 | 3 | 0.604 |
MST1 |
0.619 | -0.116 | 1 | 0.288 |
RIPK2 |
0.619 | -0.168 | 1 | 0.284 |
CK1A2 |
0.619 | -0.082 | -3 | 0.382 |
NEK4 |
0.618 | -0.194 | 1 | 0.289 |
BUB1 |
0.617 | -0.049 | -5 | 0.705 |
MRCKA |
0.617 | -0.072 | -3 | 0.669 |
TAK1 |
0.617 | -0.180 | 1 | 0.319 |
MRCKB |
0.616 | -0.064 | -3 | 0.642 |
NEK3 |
0.615 | -0.130 | 1 | 0.312 |
HPK1 |
0.615 | -0.127 | 1 | 0.294 |
PDHK3_TYR |
0.615 | 0.055 | 4 | 0.613 |
VRK1 |
0.613 | -0.199 | 2 | 0.702 |
GCK |
0.613 | -0.174 | 1 | 0.297 |
MAP3K15 |
0.612 | -0.198 | 1 | 0.303 |
MEKK6 |
0.612 | -0.201 | 1 | 0.310 |
CK1G1 |
0.612 | -0.130 | -3 | 0.448 |
STK33 |
0.611 | -0.139 | 2 | 0.510 |
NEK1 |
0.611 | -0.194 | 1 | 0.300 |
ROCK2 |
0.611 | -0.081 | -3 | 0.679 |
DMPK1 |
0.610 | -0.039 | -3 | 0.663 |
BIKE |
0.610 | -0.046 | 1 | 0.315 |
YSK1 |
0.608 | -0.151 | 2 | 0.600 |
BMPR2_TYR |
0.607 | 0.013 | -1 | 0.808 |
KHS1 |
0.607 | -0.138 | 1 | 0.295 |
MAP2K4_TYR |
0.606 | -0.037 | -1 | 0.794 |
MAP2K7_TYR |
0.606 | -0.058 | 2 | 0.709 |
KHS2 |
0.605 | -0.121 | 1 | 0.300 |
MAP2K6_TYR |
0.605 | -0.026 | -1 | 0.813 |
TESK1_TYR |
0.604 | -0.097 | 3 | 0.654 |
LIMK2_TYR |
0.603 | 0.001 | -3 | 0.795 |
PKMYT1_TYR |
0.602 | -0.014 | 3 | 0.615 |
EPHA6 |
0.602 | -0.043 | -1 | 0.810 |
HASPIN |
0.602 | -0.073 | -1 | 0.588 |
PDHK4_TYR |
0.600 | -0.090 | 2 | 0.720 |
ALPHAK3 |
0.600 | -0.089 | -1 | 0.736 |
ROCK1 |
0.599 | -0.086 | -3 | 0.658 |
PDHK1_TYR |
0.599 | -0.096 | -1 | 0.825 |
CRIK |
0.599 | -0.060 | -3 | 0.612 |
PINK1_TYR |
0.599 | -0.158 | 1 | 0.399 |
AAK1 |
0.598 | -0.026 | 1 | 0.284 |
LIMK1_TYR |
0.597 | -0.065 | 2 | 0.694 |
TAO1 |
0.597 | -0.132 | 1 | 0.284 |
MYO3B |
0.597 | -0.125 | 2 | 0.627 |
MYO3A |
0.597 | -0.119 | 1 | 0.292 |
YANK3 |
0.597 | -0.074 | 2 | 0.379 |
OSR1 |
0.595 | -0.182 | 2 | 0.585 |
ASK1 |
0.594 | -0.168 | 1 | 0.306 |
EPHA4 |
0.594 | -0.045 | 2 | 0.691 |
DDR1 |
0.592 | -0.115 | 4 | 0.566 |
JAK2 |
0.591 | -0.155 | 1 | 0.361 |
RET |
0.589 | -0.210 | 1 | 0.347 |
TTK |
0.589 | -0.196 | -2 | 0.573 |
TYK2 |
0.589 | -0.220 | 1 | 0.342 |
TNNI3K_TYR |
0.588 | -0.068 | 1 | 0.366 |
MST1R |
0.588 | -0.170 | 3 | 0.553 |
EPHB4 |
0.588 | -0.149 | -1 | 0.772 |
JAK3 |
0.587 | -0.141 | 1 | 0.350 |
STLK3 |
0.586 | -0.174 | 1 | 0.274 |
FGFR2 |
0.586 | -0.102 | 3 | 0.542 |
FGFR1 |
0.585 | -0.103 | 3 | 0.525 |
CK1A |
0.583 | -0.109 | -3 | 0.304 |
EPHB1 |
0.583 | -0.149 | 1 | 0.375 |
FER |
0.583 | -0.172 | 1 | 0.404 |
EPHB2 |
0.582 | -0.121 | -1 | 0.756 |
TYRO3 |
0.582 | -0.239 | 3 | 0.538 |
ROS1 |
0.582 | -0.218 | 3 | 0.508 |
TEK |
0.581 | -0.100 | 3 | 0.472 |
CSF1R |
0.581 | -0.182 | 3 | 0.516 |
EPHB3 |
0.581 | -0.147 | -1 | 0.758 |
INSRR |
0.580 | -0.163 | 3 | 0.490 |
SRMS |
0.579 | -0.156 | 1 | 0.374 |
ABL2 |
0.579 | -0.165 | -1 | 0.723 |
NEK10_TYR |
0.579 | -0.136 | 1 | 0.288 |
HCK |
0.578 | -0.166 | -1 | 0.719 |
LCK |
0.577 | -0.147 | -1 | 0.726 |
ABL1 |
0.577 | -0.159 | -1 | 0.708 |
EPHA3 |
0.576 | -0.113 | 2 | 0.662 |
YES1 |
0.575 | -0.164 | -1 | 0.704 |
TXK |
0.575 | -0.151 | 1 | 0.375 |
FGFR3 |
0.575 | -0.115 | 3 | 0.516 |
FLT3 |
0.575 | -0.204 | 3 | 0.521 |
FGR |
0.574 | -0.213 | 1 | 0.338 |
EPHA7 |
0.574 | -0.124 | 2 | 0.683 |
EGFR |
0.573 | -0.075 | 1 | 0.273 |
BLK |
0.573 | -0.140 | -1 | 0.735 |
ERBB2 |
0.572 | -0.146 | 1 | 0.312 |
PDGFRB |
0.572 | -0.239 | 3 | 0.532 |
JAK1 |
0.572 | -0.161 | 1 | 0.309 |
KDR |
0.572 | -0.181 | 3 | 0.484 |
TNK1 |
0.572 | -0.168 | 3 | 0.523 |
ITK |
0.572 | -0.190 | -1 | 0.701 |
KIT |
0.572 | -0.190 | 3 | 0.518 |
PDGFRA |
0.571 | -0.224 | 3 | 0.524 |
EPHA5 |
0.571 | -0.113 | 2 | 0.689 |
TNK2 |
0.571 | -0.193 | 3 | 0.494 |
FLT1 |
0.570 | -0.146 | -1 | 0.817 |
FLT4 |
0.570 | -0.156 | 3 | 0.489 |
MERTK |
0.570 | -0.186 | 3 | 0.519 |
BTK |
0.570 | -0.204 | -1 | 0.642 |
AXL |
0.569 | -0.210 | 3 | 0.519 |
NTRK1 |
0.569 | -0.203 | -1 | 0.746 |
PTK2 |
0.568 | -0.052 | -1 | 0.762 |
EPHA8 |
0.568 | -0.115 | -1 | 0.749 |
ALK |
0.567 | -0.199 | 3 | 0.465 |
FRK |
0.566 | -0.171 | -1 | 0.747 |
FYN |
0.566 | -0.119 | -1 | 0.693 |
LTK |
0.566 | -0.193 | 3 | 0.494 |
YANK2 |
0.566 | -0.090 | 2 | 0.400 |
SYK |
0.566 | -0.073 | -1 | 0.754 |
LYN |
0.566 | -0.151 | 3 | 0.463 |
NTRK2 |
0.564 | -0.204 | 3 | 0.487 |
INSR |
0.564 | -0.179 | 3 | 0.477 |
BMX |
0.564 | -0.167 | -1 | 0.607 |
MET |
0.564 | -0.198 | 3 | 0.518 |
WEE1_TYR |
0.564 | -0.149 | -1 | 0.655 |
CK1G3 |
0.563 | -0.110 | -3 | 0.259 |
PTK6 |
0.563 | -0.207 | -1 | 0.628 |
EPHA1 |
0.563 | -0.204 | 3 | 0.494 |
NTRK3 |
0.563 | -0.163 | -1 | 0.698 |
DDR2 |
0.563 | -0.141 | 3 | 0.477 |
PTK2B |
0.562 | -0.142 | -1 | 0.656 |
TEC |
0.561 | -0.207 | -1 | 0.621 |
CSK |
0.561 | -0.143 | 2 | 0.685 |
EPHA2 |
0.561 | -0.114 | -1 | 0.732 |
FGFR4 |
0.558 | -0.125 | -1 | 0.711 |
SRC |
0.557 | -0.150 | -1 | 0.679 |
MUSK |
0.557 | -0.138 | 1 | 0.247 |
ERBB4 |
0.556 | -0.095 | 1 | 0.290 |
IGF1R |
0.554 | -0.148 | 3 | 0.431 |
MATK |
0.553 | -0.160 | -1 | 0.661 |
CK1G2 |
0.547 | -0.113 | -3 | 0.357 |
FES |
0.540 | -0.151 | -1 | 0.584 |
ZAP70 |
0.534 | -0.117 | -1 | 0.663 |