Motif 539 (n=44)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
O75526	RBMXL2	S58	ochoa	RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)	None
P05455	SSB	S160	ochoa	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269\|PubMed:12384597, ECO:0000269\|PubMed:2470590, ECO:0000269\|PubMed:3192525}.
P11055	MYH3	Y554	ochoa	Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)	Muscle contraction.
P11940	PABPC1	S342	ochoa	Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)	Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:17212783, ECO:0000269\|PubMed:18447585, ECO:0000269\|PubMed:20573744, ECO:0000269\|PubMed:25480299, ECO:0000269\|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269\|PubMed:26735137}.
P13535	MYH8	Y556	ochoa	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	Muscle contraction.
P19338	NCL	S356	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	S619	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P22626	HNRNPA2B1	S71	ochoa	Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)	Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250\|UniProtKB:A7VJC2, ECO:0000269\|PubMed:10567417, ECO:0000269\|PubMed:20010808, ECO:0000269\|PubMed:24356509, ECO:0000269\|PubMed:26321680, ECO:0000303\|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269\|PubMed:15294897, ECO:0000269\|PubMed:17004321}.
P29558	RBMS1	S112	ochoa	RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2)	Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.
P31943	HNRNPH1	S63	ochoa	Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269\|PubMed:11003644, ECO:0000269\|PubMed:16946708}.
P31943	HNRNPH1	S161	ochoa	Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269\|PubMed:11003644, ECO:0000269\|PubMed:16946708}.
P38159	RBMX	S58	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P52272	HNRNPM	S701	ochoa	Heterogeneous nuclear ribonucleoprotein M (hnRNP M)	Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
P52597	HNRNPF	S161	ochoa	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269\|PubMed:20526337}.
P55795	HNRNPH2	S63	ochoa	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P55795	HNRNPH2	S161	ochoa	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P55884	EIF3B	S239	ochoa	Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255\|HAMAP-Rule:MF_03001, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815, ECO:0000269\|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
Q13243	SRSF5	S153	ochoa	Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)	Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Q13310	PABPC4	S342	ochoa	Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)	Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250\|UniProtKB:P11940, ECO:0000269\|PubMed:37009826, ECO:0000269\|PubMed:8524242}.
Q15434	RBMS2	S106	ochoa	RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)	None
Q4VXU2	PABPC1L	S342	ochoa	Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like)	Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250\|UniProtKB:A2A5N3, ECO:0000269\|PubMed:37052235, ECO:0000269\|PubMed:37723834}.
Q6XE24	RBMS3	S111	ochoa	RNA-binding motif, single-stranded-interacting protein 3	Binds poly(A) and poly(U) oligoribonucleotides. {ECO:0000269\|PubMed:10675610}.
Q8N7X1	RBMXL3	S58	ochoa	RNA-binding motif protein, X-linked-like-3	None
Q96E39	RBMXL1	S58	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q9GZT3	SLIRP	S69	ochoa	SRA stem-loop-interacting RNA-binding protein, mitochondrial	RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269\|PubMed:16762838}.
Q9H361	PABPC3	S342	ochoa	Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein)	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.
Q9NTZ6	RBM12	S352	ochoa	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)	None
Q9P2K5	MYEF2	S571	ochoa	Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)	Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}.
Q9UKX2	MYH2	Y556	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX3	MYH13	Y555	ochoa	Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)	Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269\|PubMed:23908353}.
Q9Y490	TLN1	S52	ochoa	Talin-1	High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250\|UniProtKB:P26039}.
P19338	NCL	S532	Sugiyama	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
A6NKT7	RGPD3	T1210	Sugiyama	RanBP2-like and GRIP domain-containing protein 3	None
O14715	RGPD8	T1209	Sugiyama	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	None
P0DJD0	RGPD1	T1194	Sugiyama	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	None
P49792	RANBP2	T2185	Sugiyama	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
Q7Z3J3	RGPD4	T1210	Sugiyama	RanBP2-like and GRIP domain-containing protein 4	None
Q99666	RGPD5	T1209	Sugiyama	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	None
P52597	HNRNPF	S63	Sugiyama	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269\|PubMed:20526337}.
Q16836	HADH	S196	Sugiyama	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)	Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250\|UniProtKB:Q61425, ECO:0000269\|PubMed:10231530, ECO:0000269\|PubMed:11489939, ECO:0000269\|PubMed:16725361}.
Q12849	GRSF1	S202	Sugiyama	G-rich sequence factor 1 (GRSF-1)	Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269\|PubMed:23473033, ECO:0000269\|PubMed:23473034, ECO:0000269\|PubMed:29967381}.
H0YHG0	None	S428	ochoa	DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein)	Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256\|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256\|ARBA:ARBA00055510}.
P82979	SARNP	S115	ochoa	SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29)	Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269\|PubMed:15338056, ECO:0000269\|PubMed:17196963, ECO:0000269\|PubMed:20844015, ECO:0000269\|PubMed:37578863}.
O14490	DLGAP1	S169	ochoa	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	Part of the postsynaptic scaffold in neuronal cells.

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reactome_id	name	p	-log10_p
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	6.718499e-08	7.173
R-HSA-8953854	Metabolism of RNA	1.600518e-07	6.796
R-HSA-72163	mRNA Splicing - Major Pathway	1.273346e-06	5.895
R-HSA-72172	mRNA Splicing	1.773753e-06	5.751
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	4.119275e-05	4.385
R-HSA-6803529	FGFR2 alternative splicing	5.736271e-05	4.241
R-HSA-9020591	Interleukin-12 signaling	7.073724e-05	4.150
R-HSA-447115	Interleukin-12 family signaling	1.179786e-04	3.928
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	1.044258e-03	2.981
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	1.044258e-03	2.981
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	1.044258e-03	2.981
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	1.261736e-03	2.899
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	1.414330e-03	2.849
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	1.702889e-03	2.769
R-HSA-5654738	Signaling by FGFR2	1.597622e-03	2.797
R-HSA-9836573	Mitochondrial RNA degradation	2.843862e-03	2.546
R-HSA-190236	Signaling by FGFR	2.923223e-03	2.534
R-HSA-390522	Striated Muscle Contraction	4.973189e-03	2.303
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	8.546494e-03	2.068
R-HSA-72187	mRNA 3'-end processing	1.082807e-02	1.965
R-HSA-72649	Translation initiation complex formation	1.152412e-02	1.938
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	1.297376e-02	1.887
R-HSA-73856	RNA Polymerase II Transcription Termination	1.411050e-02	1.850
R-HSA-397014	Muscle contraction	2.261041e-02	1.646
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	4.089249e-02	1.388
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	5.085777e-02	1.294
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	5.580243e-02	1.253
R-HSA-429947	Deadenylation of mRNA	7.533084e-02	1.123
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	8.971784e-02	1.047
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	9.209433e-02	1.036
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	9.209433e-02	1.036
R-HSA-1855170	IPs transport between nucleus and cytosol	9.682916e-02	1.014
R-HSA-159227	Transport of the SLBP independent Mature mRNA	9.682916e-02	1.014
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	9.918753e-02	1.004
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	1.038862e-01	0.983
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	1.132120e-01	0.946
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	1.155286e-01	0.937
R-HSA-72702	Ribosomal scanning and start codon recognition	1.540187e-01	0.812
R-HSA-354192	Integrin signaling	9.682916e-02	1.014
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	1.737288e-01	0.760
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	4.089249e-02	1.388
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	4.089249e-02	1.388
R-HSA-76009	Platelet Aggregation (Plug Formation)	1.293046e-01	0.888
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	1.085610e-01	0.964
R-HSA-5674135	MAP2K and MAPK activation	1.201441e-01	0.920
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	9.209433e-02	1.036
R-HSA-9656223	Signaling by RAF1 mutants	1.201441e-01	0.920
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	1.315802e-01	0.881
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	1.315802e-01	0.881
R-HSA-9649948	Signaling downstream of RAS mutants	1.315802e-01	0.881
R-HSA-73980	RNA Polymerase III Transcription Termination	5.826532e-02	1.235
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	1.062266e-01	0.974
R-HSA-180910	Vpr-mediated nuclear import of PICs	1.085610e-01	0.964
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	1.293046e-01	0.888
R-HSA-6802949	Signaling by RAS mutants	1.315802e-01	0.881
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	9.918753e-02	1.004
R-HSA-429914	Deadenylation-dependent mRNA decay	1.606392e-01	0.794
R-HSA-72737	Cap-dependent Translation Initiation	4.535079e-02	1.343
R-HSA-72613	Eukaryotic Translation Initiation	4.535079e-02	1.343
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	3.081087e-02	1.511
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	5.333325e-02	1.273
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	1.315802e-01	0.881
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.927373e-02	1.406
R-HSA-191859	snRNP Assembly	1.606392e-01	0.794
R-HSA-194441	Metabolism of non-coding RNA	1.606392e-01	0.794
R-HSA-168325	Viral Messenger RNA Synthesis	1.650247e-01	0.782
R-HSA-180746	Nuclear import of Rev protein	1.015399e-01	0.993
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	1.178393e-01	0.929
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	4.837596e-02	1.315
R-HSA-177243	Interactions of Rev with host cellular proteins	1.155286e-01	0.937
R-HSA-176033	Interactions of Vpr with host cellular proteins	1.155286e-01	0.937
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	1.178393e-01	0.929
R-HSA-445355	Smooth Muscle Contraction	1.473472e-01	0.832
R-HSA-168273	Influenza Viral RNA Transcription and Replication	7.492998e-02	1.125
R-HSA-6794361	Neurexins and neuroligins	1.451120e-01	0.838
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	1.108895e-01	0.955
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	1.315802e-01	0.881
R-HSA-5578749	Transcriptional regulation by small RNAs	1.887482e-01	0.724
R-HSA-168276	NS1 Mediated Effects on Host Pathways	1.132120e-01	0.946
R-HSA-2980766	Nuclear Envelope Breakdown	1.562312e-01	0.806
R-HSA-6784531	tRNA processing in the nucleus	1.672091e-01	0.777
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	5.085777e-02	1.294
R-HSA-9937008	Mitochondrial mRNA modification	7.291152e-02	1.137
R-HSA-168255	Influenza Infection	9.429372e-02	1.026
R-HSA-1482798	Acyl chain remodeling of CL	4.588783e-02	1.338
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	1.062266e-01	0.974
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	1.887482e-01	0.724
R-HSA-74158	RNA Polymerase III Transcription	1.062266e-01	0.974
R-HSA-373755	Semaphorin interactions	1.693879e-01	0.771
R-HSA-381038	XBP1(S) activates chaperone genes	2.563570e-02	1.591
R-HSA-381070	IRE1alpha activates chaperones	2.869431e-02	1.542
R-HSA-381119	Unfolded Protein Response (UPR)	6.261786e-02	1.203
R-HSA-449147	Signaling by Interleukins	8.691801e-02	1.061
R-HSA-1280215	Cytokine Signaling in Immune system	1.545577e-01	0.811
R-HSA-1169408	ISG15 antiviral mechanism	1.951032e-01	0.710
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	2.055871e-01	0.687
R-HSA-6802957	Oncogenic MAPK signaling	2.159376e-01	0.666
R-HSA-6794362	Protein-protein interactions at synapses	2.159376e-01	0.666
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	2.179918e-01	0.662
R-HSA-141424	Amplification of signal from the kinetochores	2.179918e-01	0.662
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	2.287014e-01	0.641
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	2.322252e-01	0.634
R-HSA-9837999	Mitochondrial protein degradation	2.382475e-01	0.623
R-HSA-72689	Formation of a pool of free 40S subunits	2.422367e-01	0.616
R-HSA-69618	Mitotic Spindle Checkpoint	2.521207e-01	0.598
R-HSA-70171	Glycolysis	2.521207e-01	0.598
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	2.560390e-01	0.592
R-HSA-192823	Viral mRNA Translation	2.579906e-01	0.588
R-HSA-9860931	Response of endothelial cells to shear stress	2.599372e-01	0.585
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	2.676740e-01	0.572
R-HSA-9700206	Signaling by ALK in cancer	2.676740e-01	0.572
R-HSA-211000	Gene Silencing by RNA	2.676740e-01	0.572
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.695958e-01	0.569
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	2.715127e-01	0.566
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.772339e-01	0.557
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.772339e-01	0.557
R-HSA-1483249	Inositol phosphate metabolism	2.772339e-01	0.557
R-HSA-9855142	Cellular responses to mechanical stimuli	2.810237e-01	0.551
R-HSA-70326	Glucose metabolism	2.904135e-01	0.537
R-HSA-68875	Mitotic Prophase	2.959898e-01	0.529
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	2.978390e-01	0.526
R-HSA-3371556	Cellular response to heat stress	2.978390e-01	0.526
R-HSA-9816359	Maternal to zygotic transition (MZT)	3.015233e-01	0.521
R-HSA-162909	Host Interactions of HIV factors	3.033583e-01	0.518
R-HSA-8978868	Fatty acid metabolism	3.074961e-01	0.512
R-HSA-114608	Platelet degranulation	3.106516e-01	0.508
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.232358e-01	0.490
R-HSA-72766	Translation	3.287235e-01	0.483
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	3.320869e-01	0.479
R-HSA-9664407	Parasite infection	3.373433e-01	0.472
R-HSA-9664422	FCGR3A-mediated phagocytosis	3.373433e-01	0.472
R-HSA-9664417	Leishmania phagocytosis	3.373433e-01	0.472
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	3.390864e-01	0.470
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	3.425592e-01	0.465
R-HSA-162599	Late Phase of HIV Life Cycle	3.425592e-01	0.465
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.596579e-01	0.444
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	3.630252e-01	0.440
R-HSA-9610379	HCMV Late Events	3.680437e-01	0.434
R-HSA-162587	HIV Life Cycle	3.680437e-01	0.434
R-HSA-2467813	Separation of Sister Chromatids	3.796039e-01	0.421
R-HSA-5619102	SLC transporter disorders	3.844948e-01	0.415
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.909576e-01	0.408
R-HSA-72306	tRNA processing	3.909576e-01	0.408
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	3.973541e-01	0.401
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	4.097960e-01	0.387
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.192295e-01	0.378
R-HSA-68877	Mitotic Prometaphase	4.268527e-01	0.370
R-HSA-9609690	HCMV Early Events	4.313796e-01	0.365
R-HSA-422475	Axon guidance	4.370621e-01	0.359
R-HSA-376176	Signaling by ROBO receptors	4.418072e-01	0.355
R-HSA-1483206	Glycerophospholipid biosynthesis	4.418072e-01	0.355
R-HSA-68882	Mitotic Anaphase	4.621054e-01	0.335
R-HSA-2555396	Mitotic Metaphase and Anaphase	4.635273e-01	0.334
R-HSA-9675108	Nervous system development	4.697860e-01	0.328
R-HSA-162906	HIV Infection	4.775467e-01	0.321
R-HSA-9705683	SARS-CoV-2-host interactions	4.789288e-01	0.320
R-HSA-72312	rRNA processing	4.844217e-01	0.315
R-HSA-5619115	Disorders of transmembrane transporters	5.045208e-01	0.297
R-HSA-9609646	HCMV Infection	5.084479e-01	0.294
R-HSA-2262752	Cellular responses to stress	5.145936e-01	0.289
R-HSA-69620	Cell Cycle Checkpoints	5.187720e-01	0.285
R-HSA-76002	Platelet activation, signaling and aggregation	5.387892e-01	0.269
R-HSA-9824443	Parasitic Infection Pathways	5.472889e-01	0.262
R-HSA-9658195	Leishmania infection	5.472889e-01	0.262
R-HSA-5673001	RAF/MAP kinase cascade	5.568158e-01	0.254
R-HSA-1483257	Phospholipid metabolism	5.638322e-01	0.249
R-HSA-5684996	MAPK1/MAPK3 signaling	5.649910e-01	0.248
R-HSA-9824446	Viral Infection Pathways	5.837854e-01	0.234
R-HSA-8953897	Cellular responses to stimuli	5.946343e-01	0.226
R-HSA-5683057	MAPK family signaling cascades	6.202679e-01	0.207
R-HSA-9694516	SARS-CoV-2 Infection	6.222897e-01	0.206
R-HSA-68886	M Phase	6.550945e-01	0.184
R-HSA-913531	Interferon Signaling	6.560160e-01	0.183
R-HSA-5663205	Infectious disease	6.659020e-01	0.177
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	7.164103e-01	0.145
R-HSA-112316	Neuronal System	7.261517e-01	0.139
R-HSA-168256	Immune System	7.596289e-01	0.119
R-HSA-74160	Gene expression (Transcription)	7.792720e-01	0.108
R-HSA-9679506	SARS-CoV Infections	7.834332e-01	0.106
R-HSA-69278	Cell Cycle, Mitotic	7.897843e-01	0.102
R-HSA-162582	Signal Transduction	8.326400e-01	0.080
R-HSA-1640170	Cell Cycle	8.571226e-01	0.067
R-HSA-109582	Hemostasis	8.839700e-01	0.054
R-HSA-1643685	Disease	8.878313e-01	0.052
R-HSA-392499	Metabolism of proteins	8.960954e-01	0.048
R-HSA-556833	Metabolism of lipids	9.142959e-01	0.039
R-HSA-73857	RNA Polymerase II Transcription	9.469682e-01	0.024
R-HSA-1266738	Developmental Biology	9.713003e-01	0.013
R-HSA-168249	Innate Immune System	9.747135e-01	0.011
R-HSA-597592	Post-translational protein modification	9.902220e-01	0.004
R-HSA-1430728	Metabolism	9.986924e-01	0.001

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kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
FAM20C	0.544	0.220	2	0.704
CHK1	0.521	0.135	-3	0.568
CAMK2G	0.518	0.076	2	0.528
JNK2	0.515	0.185	1	0.699
CDK8	0.515	0.168	1	0.705
ATM	0.514	0.054	1	0.549
CAMK2B	0.514	0.066	2	0.612
DNAPK	0.514	0.081	1	0.550
CDC7	0.513	0.022	1	0.603
P38B	0.513	0.175	1	0.678
CK2A2	0.513	0.112	1	0.498
JNK3	0.512	0.177	1	0.718
CAMK2D	0.511	0.062	-3	0.535
P38D	0.511	0.176	1	0.707
ATR	0.510	0.025	1	0.566
MOS	0.510	-0.016	1	0.622
NLK	0.509	0.090	1	0.673
CAMK2A	0.509	0.055	2	0.559
MARK4	0.509	0.028	4	0.497
MARK2	0.508	0.057	4	0.484
SBK	0.508	0.082	-3	0.363
HIPK4	0.508	0.065	1	0.659
PDHK4	0.507	-0.012	1	0.554
CAMK1B	0.507	-0.008	-3	0.571
PRPK	0.507	-0.065	-1	0.506
TSSK2	0.506	0.000	-5	0.387
SMG1	0.506	0.072	1	0.540
P38A	0.506	0.147	1	0.681
PDHK1	0.506	-0.006	1	0.538
MAPKAPK3	0.506	0.045	-3	0.493
CDK19	0.506	0.159	1	0.690
MAPKAPK2	0.506	0.025	-3	0.483
IKKB	0.505	0.018	-2	0.392
ERK5	0.505	0.039	1	0.594
GRK6	0.505	0.018	1	0.501
CDK7	0.504	0.139	1	0.724
IKKE	0.503	-0.012	1	0.451
JNK1	0.502	0.155	1	0.696
MARK1	0.502	0.057	4	0.474
PRKD1	0.501	-0.040	-3	0.533
MARK3	0.501	0.041	4	0.486
CK2A1	0.501	0.082	1	0.472
CLK3	0.501	0.031	1	0.687
BMPR2	0.500	-0.095	-2	0.310
BCKDK	0.500	-0.008	-1	0.451
IKKA	0.500	-0.018	-2	0.369
CDK5	0.500	0.136	1	0.714
TBK1	0.500	-0.053	1	0.449
DYRK2	0.500	0.117	1	0.673
TGFBR1	0.499	-0.011	-2	0.210
P38G	0.498	0.158	1	0.655
GRK5	0.498	-0.025	-3	0.556
KIS	0.498	0.106	1	0.715
CDKL1	0.498	-0.008	-3	0.517
CDK9	0.497	0.156	1	0.702
MEK1	0.497	0.122	2	0.387
TSSK1	0.497	-0.021	-3	0.556
ALK2	0.497	0.012	-2	0.228
GRK1	0.496	0.001	-2	0.361
ICK	0.496	0.015	-3	0.538
RAF1	0.496	-0.125	1	0.519
DYRK4	0.496	0.133	1	0.682
ERK1	0.495	0.142	1	0.679
AMPKA2	0.495	-0.013	-3	0.522
AMPKA1	0.495	-0.032	-3	0.540
PLK3	0.494	-0.002	2	0.423
CDK2	0.494	0.102	1	0.662
CDKL5	0.494	-0.007	-3	0.508
DSTYK	0.494	-0.082	2	0.481
CDK13	0.494	0.140	1	0.713
MTOR	0.494	-0.057	1	0.570
QSK	0.494	-0.002	4	0.498
SIK	0.493	-0.001	-3	0.485
PRKD2	0.493	-0.035	-3	0.495
COT	0.493	-0.139	2	0.440
QIK	0.493	0.002	-3	0.512
CDK18	0.492	0.135	1	0.674
CDK1	0.492	0.129	1	0.683
BRSK1	0.492	-0.001	-3	0.505
CDK17	0.491	0.143	1	0.659
CAMLCK	0.491	-0.063	-2	0.317
MASTL	0.490	-0.064	-2	0.372
BMPR1B	0.490	-0.028	1	0.480
ERK2	0.490	0.125	1	0.678
DAPK2	0.490	-0.080	-3	0.558
NDR2	0.490	-0.081	-3	0.543
PIM3	0.490	-0.077	-3	0.545
DYRK1A	0.489	0.079	1	0.709
PRP4	0.489	0.059	-3	0.479
NIK	0.489	-0.112	-3	0.586
BMPR1A	0.489	-0.008	1	0.487
CDK16	0.489	0.125	1	0.671
NUAK2	0.488	-0.048	-3	0.522
ALK4	0.488	-0.050	-2	0.235
WNK1	0.488	-0.068	-2	0.328
TLK1	0.488	-0.030	-2	0.216
ACVR2B	0.488	-0.042	-2	0.224
PKN3	0.488	-0.077	-3	0.534
CDK3	0.488	0.128	1	0.672
GCN2	0.488	-0.110	2	0.357
LATS2	0.488	-0.053	-5	0.296
PIM1	0.488	-0.041	-3	0.499
SRPK1	0.487	0.018	-3	0.474
SSTK	0.487	-0.035	4	0.483
CDK12	0.487	0.133	1	0.703
CAMK4	0.486	-0.035	-3	0.525
RSK2	0.486	-0.053	-3	0.504
WNK3	0.486	-0.124	1	0.489
PLK2	0.485	0.013	-3	0.651
PRKD3	0.485	-0.045	-3	0.470
P70S6KB	0.485	-0.072	-3	0.518
GRK4	0.485	-0.099	-2	0.272
NIM1	0.484	-0.055	3	0.518
CAMK1D	0.484	-0.007	-3	0.438
P90RSK	0.484	-0.061	-3	0.504
HIPK3	0.483	0.093	1	0.660
ACVR2A	0.483	-0.060	-2	0.214
LATS1	0.483	-0.052	-3	0.563
HIPK2	0.483	0.102	1	0.663
SRPK2	0.483	0.010	-3	0.432
BRSK2	0.483	-0.032	-3	0.520
PAK6	0.482	-0.019	-2	0.290
PINK1	0.482	-0.016	1	0.608
DYRK1B	0.482	0.096	1	0.664
SRPK3	0.481	0.000	-3	0.456
NDR1	0.481	-0.105	-3	0.548
MLK2	0.481	-0.098	2	0.351
TGFBR2	0.480	-0.123	-2	0.205
CLK4	0.480	0.021	-3	0.490
BRAF	0.480	-0.088	-4	0.296
MELK	0.480	-0.049	-3	0.520
CLK1	0.480	0.043	-3	0.485
HIPK1	0.479	0.070	1	0.663
NUAK1	0.479	-0.064	-3	0.518
ERK7	0.479	0.015	2	0.176
CDK14	0.479	0.110	1	0.676
GSK3A	0.479	-0.015	4	0.108
YSK4	0.479	-0.057	1	0.452
MAPKAPK5	0.479	-0.033	-3	0.438
HUNK	0.479	-0.138	2	0.348
PKACG	0.479	-0.071	-2	0.343
MST4	0.478	-0.106	2	0.350
ULK2	0.478	-0.188	2	0.304
CDK10	0.478	0.111	1	0.675
RSK3	0.478	-0.067	-3	0.504
SKMLCK	0.477	-0.116	-2	0.286
MSK1	0.477	-0.054	-3	0.462
AURA	0.477	-0.062	-2	0.209
TLK2	0.477	-0.118	1	0.527
VRK2	0.477	-0.154	1	0.547
CAMK1A	0.476	-0.012	-3	0.429
CDK4	0.476	0.130	1	0.700
DYRK3	0.476	0.053	1	0.646
GRK7	0.476	-0.069	1	0.469
MYLK4	0.476	-0.053	-2	0.272
DLK	0.475	-0.195	1	0.475
NEK6	0.475	-0.159	-2	0.279
TTBK2	0.475	-0.140	2	0.278
GRK2	0.475	-0.068	-2	0.262
MLK1	0.474	-0.146	2	0.325
MSK2	0.474	-0.065	-3	0.454
CDK6	0.474	0.120	1	0.679
PIM2	0.474	-0.051	-3	0.477
NEK7	0.474	-0.195	-3	0.505
CAMKK2	0.473	-0.013	-2	0.448
PLK1	0.473	-0.131	-2	0.239
ANKRD3	0.473	-0.193	1	0.491
NEK9	0.473	-0.164	2	0.340
CAMKK1	0.472	-0.039	-2	0.407
PKN2	0.472	-0.126	-3	0.528
AURB	0.472	-0.074	-2	0.252
PKR	0.472	-0.136	1	0.484
ULK1	0.472	-0.166	-3	0.529
RSK4	0.472	-0.066	-3	0.480
NEK2	0.472	-0.085	2	0.300
SNRK	0.471	-0.077	2	0.214
CHAK2	0.471	-0.131	-1	0.430
SMMLCK	0.471	-0.058	-3	0.528
PKG2	0.471	-0.064	-2	0.308
CLK2	0.471	0.018	-3	0.492
TTBK1	0.471	-0.053	2	0.221
AURC	0.471	-0.077	-2	0.255
MNK2	0.471	-0.099	-2	0.293
MEK5	0.471	-0.086	2	0.339
RIPK3	0.470	-0.173	3	0.422
GSK3B	0.470	-0.048	4	0.108
PKACB	0.470	-0.066	-2	0.263
PKACA	0.469	-0.046	-2	0.266
MAK	0.469	0.051	-2	0.285
HRI	0.469	-0.127	-2	0.280
AKT2	0.468	-0.058	-3	0.424
PERK	0.468	-0.103	-2	0.311
SGK3	0.468	-0.068	-3	0.463
RIPK1	0.467	-0.185	1	0.429
P70S6K	0.467	-0.060	-3	0.443
CAMK1G	0.467	-0.076	-3	0.488
PRKX	0.467	-0.042	-3	0.410
WNK4	0.467	-0.109	-2	0.325
DCAMKL2	0.467	-0.058	-3	0.531
PAK3	0.466	-0.123	-2	0.280
GRK3	0.465	-0.071	-2	0.227
MOK	0.465	0.036	1	0.600
MST2	0.465	-0.053	1	0.471
PKCD	0.465	-0.139	2	0.301
MEK2	0.464	-0.023	2	0.345
DCAMKL1	0.463	-0.096	-3	0.503
PAK1	0.463	-0.125	-2	0.266
IRE2	0.463	-0.152	2	0.243
MPSK1	0.463	-0.071	1	0.478
IRAK1	0.463	-0.119	-1	0.379
PLK4	0.462	-0.135	2	0.202
MEKK2	0.462	-0.153	2	0.332
MEKK3	0.462	-0.164	1	0.438
PAK5	0.461	-0.072	-2	0.253
PHKG1	0.461	-0.111	-3	0.530
LKB1	0.461	-0.109	-3	0.499
DRAK1	0.461	-0.135	1	0.408
IRE1	0.461	-0.160	1	0.431
PASK	0.461	-0.104	-3	0.526
PHKG2	0.461	-0.095	-3	0.517
PAK2	0.461	-0.133	-2	0.272
TAO2	0.460	-0.103	2	0.352
PAK4	0.460	-0.065	-2	0.240
LRRK2	0.459	-0.043	2	0.338
PDK1	0.459	-0.089	1	0.495
TAK1	0.458	-0.100	1	0.547
LOK	0.458	-0.033	-2	0.453
MRCKA	0.458	-0.067	-3	0.490
MLK3	0.458	-0.158	2	0.270
MEKK1	0.458	-0.196	1	0.473
AKT1	0.458	-0.070	-3	0.428
CHK2	0.458	-0.043	-3	0.399
DAPK3	0.458	-0.091	-3	0.509
CHAK1	0.458	-0.171	2	0.280
PKCA	0.457	-0.116	2	0.237
GAK	0.457	-0.107	1	0.477
MNK1	0.457	-0.128	-2	0.302
PKCH	0.457	-0.122	2	0.227
PKG1	0.456	-0.053	-2	0.272
ZAK	0.456	-0.180	1	0.435
PKN1	0.456	-0.060	-3	0.445
MRCKB	0.456	-0.065	-3	0.467
PKCG	0.456	-0.128	2	0.245
PKCZ	0.455	-0.134	2	0.279
PKCB	0.454	-0.134	2	0.253
NEK11	0.454	-0.143	1	0.477
MLK4	0.454	-0.175	2	0.272
DMPK1	0.454	-0.051	-3	0.493
TAO3	0.454	-0.149	1	0.472
SGK1	0.453	-0.053	-3	0.373
EEF2K	0.453	-0.106	3	0.481
SLK	0.453	-0.040	-2	0.455
HGK	0.452	-0.088	3	0.478
MST1	0.452	-0.084	1	0.444
DAPK1	0.452	-0.090	-3	0.481
NEK4	0.452	-0.127	1	0.439
MINK	0.452	-0.091	1	0.448
IRAK4	0.452	-0.176	1	0.419
PKCI	0.451	-0.086	2	0.237
MST3	0.451	-0.144	2	0.317
NEK5	0.450	-0.219	1	0.472
HPK1	0.450	-0.084	1	0.452
GCK	0.450	-0.116	1	0.469
TNIK	0.449	-0.093	3	0.477
RIPK2	0.449	-0.113	1	0.421
PBK	0.449	-0.063	1	0.432
CRIK	0.449	-0.055	-3	0.436
CK1D	0.449	-0.085	-3	0.205
CK1E	0.449	-0.099	-3	0.251
NEK8	0.448	-0.206	2	0.299
PDHK3_TYR	0.448	0.034	4	0.415
ALPHAK3	0.448	-0.053	-1	0.479
AKT3	0.447	-0.073	-3	0.378
MAP3K15	0.447	-0.173	1	0.442
VRK1	0.447	-0.168	2	0.355
PKCT	0.446	-0.133	2	0.239
NEK3	0.445	-0.111	1	0.435
MEKK6	0.445	-0.193	1	0.458
ROCK2	0.445	-0.094	-3	0.495
BIKE	0.444	-0.047	1	0.386
CK1A2	0.444	-0.090	-3	0.205
KHS1	0.444	-0.101	1	0.462
PKCE	0.443	-0.091	2	0.224
NEK1	0.442	-0.150	1	0.429
BMPR2_TYR	0.442	0.009	-1	0.557
MAP2K4_TYR	0.441	-0.005	-1	0.539
MAP2K7_TYR	0.441	0.001	2	0.411
YSK1	0.440	-0.132	2	0.302
EPHA6	0.440	-0.016	-1	0.601
EPHA4	0.440	0.011	2	0.425
KHS2	0.439	-0.102	1	0.471
BUB1	0.438	-0.110	-5	0.330
PDHK1_TYR	0.438	-0.055	-1	0.571
MAP2K6_TYR	0.438	-0.033	-1	0.542
ROCK1	0.437	-0.094	-3	0.484
TESK1_TYR	0.437	-0.089	3	0.564
PDHK4_TYR	0.436	-0.069	2	0.450
ASK1	0.435	-0.127	1	0.446
TAO1	0.433	-0.102	1	0.427
AAK1	0.432	-0.041	1	0.321
YANK3	0.432	-0.082	2	0.150
STK33	0.431	-0.126	2	0.198
LIMK2_TYR	0.431	-0.050	-3	0.602
STLK3	0.431	-0.122	1	0.416
DDR1	0.430	-0.055	4	0.394
EPHB2	0.430	-0.046	-1	0.600
MYO3A	0.430	-0.114	1	0.441
LIMK1_TYR	0.430	-0.065	2	0.375
PKMYT1_TYR	0.429	-0.072	3	0.528
CK1G1	0.429	-0.134	-3	0.281
EPHB4	0.428	-0.086	-1	0.588
EPHB1	0.428	-0.063	1	0.496
MYO3B	0.428	-0.113	2	0.305
PINK1_TYR	0.427	-0.144	1	0.521
EPHB3	0.426	-0.057	-1	0.590
FER	0.426	-0.090	1	0.536
OSR1	0.425	-0.187	2	0.305
TTK	0.425	-0.186	-2	0.207
EPHA3	0.425	-0.047	2	0.391
JAK3	0.424	-0.090	1	0.474
HASPIN	0.424	-0.100	-1	0.278
EPHA5	0.424	-0.033	2	0.430
INSRR	0.424	-0.092	3	0.467
TEK	0.424	-0.046	3	0.446
SRMS	0.424	-0.063	1	0.500
FGFR2	0.424	-0.085	3	0.515
RET	0.423	-0.158	1	0.474
JAK2	0.423	-0.121	1	0.489
TYK2	0.422	-0.161	1	0.482
MST1R	0.422	-0.126	3	0.480
EPHA7	0.421	-0.051	2	0.390
NEK10_TYR	0.421	-0.061	1	0.443
FGFR1	0.421	-0.102	3	0.492
TXK	0.419	-0.074	1	0.477
HCK	0.418	-0.100	-1	0.555
TNNI3K_TYR	0.418	-0.073	1	0.464
YES1	0.417	-0.105	-1	0.522
EGFR	0.417	-0.047	1	0.369
ROS1	0.417	-0.170	3	0.456
LCK	0.416	-0.096	-1	0.559
FGFR3	0.416	-0.096	3	0.494
CSF1R	0.415	-0.144	3	0.446
TYRO3	0.415	-0.177	3	0.472
ERBB2	0.414	-0.090	1	0.438
EPHA8	0.413	-0.067	-1	0.574
ITK	0.413	-0.113	-1	0.507
BLK	0.413	-0.095	-1	0.571
BTK	0.412	-0.091	-1	0.476
YANK2	0.411	-0.088	2	0.177
LYN	0.411	-0.082	3	0.398
EPHA2	0.411	-0.059	-1	0.579
BMX	0.410	-0.090	-1	0.479
FGR	0.410	-0.153	1	0.444
LTK	0.409	-0.119	3	0.441
SYK	0.409	-0.056	-1	0.581
ABL2	0.409	-0.138	-1	0.517
MERTK	0.409	-0.108	3	0.472
EPHA1	0.409	-0.109	3	0.445
PTK2	0.409	-0.049	-1	0.559
FYN	0.408	-0.084	-1	0.533
PDGFRA	0.408	-0.156	3	0.447
KIT	0.408	-0.152	3	0.461
FLT3	0.408	-0.164	3	0.445
ALK	0.407	-0.136	3	0.427
FRK	0.407	-0.099	-1	0.604
CK1A	0.407	-0.120	-3	0.152
FLT1	0.407	-0.110	-1	0.577
NTRK1	0.406	-0.149	-1	0.516
JAK1	0.406	-0.132	1	0.446
ABL1	0.406	-0.142	-1	0.505
CSK	0.406	-0.087	2	0.387
AXL	0.405	-0.140	3	0.489
FLT4	0.405	-0.128	3	0.436
INSR	0.405	-0.140	3	0.447
TEC	0.404	-0.121	-1	0.472
NTRK2	0.404	-0.138	3	0.442
PDGFRB	0.403	-0.198	3	0.466
KDR	0.403	-0.175	3	0.421
FGFR4	0.403	-0.100	-1	0.522
TNK2	0.402	-0.145	3	0.443
PTK2B	0.401	-0.100	-1	0.488
MET	0.401	-0.166	3	0.459
PTK6	0.401	-0.157	-1	0.423
ERBB4	0.401	-0.064	1	0.386
CK1G3	0.400	-0.114	-3	0.120
NTRK3	0.400	-0.126	-1	0.501
SRC	0.400	-0.107	-1	0.519
IGF1R	0.399	-0.108	3	0.423
DDR2	0.398	-0.138	3	0.457
TNK1	0.396	-0.183	3	0.452
CK1G2	0.392	-0.113	-3	0.203
WEE1_TYR	0.392	-0.143	-1	0.408
MATK	0.390	-0.137	-1	0.447
FES	0.388	-0.101	-1	0.438
MUSK	0.387	-0.106	1	0.342
ZAP70	0.369	-0.117	-1	0.470