Motif 538 (n=42)

Position-wise Probabilities
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uniprot genes site source protein function
A6NKT7 RGPD3 S789 ochoa RanBP2-like and GRIP domain-containing protein 3 None
K7ERJ3 None S30 ochoa KS6B1 kinase None
O14715 RGPD8 S788 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O43299 AP5Z1 S776 ochoa AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.
O94763 URI1 S488 ochoa Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
O94875 SORBS2 Y72 ochoa Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
P0DJD0 RGPD1 S779 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S787 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P15036 ETS2 S88 ochoa Protein C-ets-2 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.
P23443 RPS6KB1 S427 ochoa|psp Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}.
P30050 RPL12 S76 ochoa Large ribosomal subunit protein uL11 (60S ribosomal protein L12) Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}.
P35498 SCN1A S551 ochoa Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14672992). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (By similarity). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity). {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:14672992}.
P46092 CCR10 S329 ochoa C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2) Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
P49792 RANBP2 S788 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P55317 FOXA1 S223 ochoa Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.
P55318 FOXA3 S170 ochoa Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G) Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269|PubMed:12695546}.
P85037 FOXK1 T202 ochoa Forkhead box protein K1 (Myocyte nuclear factor) (MNF) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}.
Q3T8J9 GON4L S1009 ochoa GON-4-like protein (GON-4 homolog) Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.
Q5SYE7 NHSL1 S723 ochoa NHS-like protein 1 None
Q6W2J9 BCOR S1439 ochoa BCL-6 corepressor (BCoR) Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.
Q7L590 MCM10 S593 ochoa Protein MCM10 homolog (HsMCM10) Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}.
Q7RTN6 STRADA S387 ochoa STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}.
Q7Z3J3 RGPD4 S789 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q8IXZ2 ZC3H3 S918 ochoa Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}.
Q8IZD2 KMT2E S795 ochoa Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.
Q8ND30 PPFIBP2 S476 ochoa Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q8NHM5 KDM2B S820 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q92615 LARP4B S572 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q96A73 KIAA1191 T175 ochoa Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.
Q99250 SCN2A S554 ochoa Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}.
Q99666 RGPD5 S788 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9C0H5 ARHGAP39 S407 ochoa Rho GTPase-activating protein 39 None
Q9H869 YY1AP1 S466 ochoa YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}.
Q9NRL3 STRN4 S635 ochoa Striatin-4 (Zinedin) Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}.
Q9NZJ5 EIF2AK3 S845 ochoa Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}.
Q9UPU9 SAMD4A S420 ochoa Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.
Q9Y4H4 GPSM3 Y85 ochoa G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18) Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. {ECO:0000269|PubMed:14656218, ECO:0000269|PubMed:15096500}.
Q13554 CAMK2B Y231 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}.
Q13555 CAMK2G Y231 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.
Q13557 CAMK2D Y231 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
Q9UQM7 CAMK2A Y230 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
Q9UBS0 RPS6KB2 S403 Sugiyama Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.
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reactome_id name p -log10_p
R-HSA-5576892 Phase 0 - rapid depolarisation 8.833019e-10 9.054
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 7.368820e-08 7.133
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.330763e-06 5.876
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.330763e-06 5.876
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.330763e-06 5.876
R-HSA-9620244 Long-term potentiation 2.292902e-06 5.640
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 5.646574e-06 5.248
R-HSA-399719 Trafficking of AMPA receptors 4.593951e-06 5.338
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 5.646574e-06 5.248
R-HSA-9022692 Regulation of MECP2 expression and activity 5.646574e-06 5.248
R-HSA-5576891 Cardiac conduction 4.507812e-06 5.346
R-HSA-111933 Calmodulin induced events 8.273614e-06 5.082
R-HSA-111997 CaM pathway 8.273614e-06 5.082
R-HSA-5673000 RAF activation 6.867670e-06 5.163
R-HSA-111996 Ca-dependent events 1.490112e-05 4.827
R-HSA-9656223 Signaling by RAF1 mutants 1.377365e-05 4.861
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.377365e-05 4.861
R-HSA-1489509 DAG and IP3 signaling 1.869238e-05 4.728
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 2.010066e-05 4.697
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 2.010066e-05 4.697
R-HSA-9649948 Signaling downstream of RAS mutants 2.010066e-05 4.697
R-HSA-6802949 Signaling by RAS mutants 2.010066e-05 4.697
R-HSA-3371571 HSF1-dependent transactivation 2.834097e-05 4.548
R-HSA-5578775 Ion homeostasis 3.882388e-05 4.411
R-HSA-112043 PLC beta mediated events 5.189777e-05 4.285
R-HSA-3371556 Cellular response to heat stress 4.738079e-05 4.324
R-HSA-397014 Muscle contraction 5.785370e-05 4.238
R-HSA-936837 Ion transport by P-type ATPases 6.113737e-05 4.214
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 6.446783e-05 4.191
R-HSA-112040 G-protein mediated events 7.152314e-05 4.146
R-HSA-6802957 Oncogenic MAPK signaling 1.627382e-04 3.789
R-HSA-438064 Post NMDA receptor activation events 1.835988e-04 3.736
R-HSA-8986944 Transcriptional Regulation by MECP2 2.143327e-04 3.669
R-HSA-2559585 Oncogene Induced Senescence 2.640180e-04 3.578
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 3.399330e-04 3.469
R-HSA-111885 Opioid Signalling 3.630981e-04 3.440
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 4.942044e-04 3.306
R-HSA-2262752 Cellular responses to stress 7.084531e-04 3.150
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 8.832787e-04 3.054
R-HSA-913531 Interferon Signaling 1.107760e-03 2.956
R-HSA-418594 G alpha (i) signalling events 1.486090e-03 2.828
R-HSA-8953897 Cellular responses to stimuli 1.703573e-03 2.769
R-HSA-877300 Interferon gamma signaling 1.786304e-03 2.748
R-HSA-112316 Neuronal System 2.893076e-03 2.539
R-HSA-983712 Ion channel transport 3.190024e-03 2.496
R-HSA-445095 Interaction between L1 and Ankyrins 4.269948e-03 2.370
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 4.692907e-03 2.329
R-HSA-210745 Regulation of gene expression in beta cells 4.785453e-03 2.320
R-HSA-9006925 Intracellular signaling by second messengers 4.017584e-03 2.396
R-HSA-165159 MTOR signalling 9.499224e-03 2.022
R-HSA-380108 Chemokine receptors bind chemokines 1.218686e-02 1.914
R-HSA-5673001 RAF/MAP kinase cascade 1.255365e-02 1.901
R-HSA-372790 Signaling by GPCR 1.319977e-02 1.879
R-HSA-5684996 MAPK1/MAPK3 signaling 1.352962e-02 1.869
R-HSA-186712 Regulation of beta-cell development 1.653089e-02 1.782
R-HSA-112315 Transmission across Chemical Synapses 1.774422e-02 1.751
R-HSA-2559583 Cellular Senescence 2.043081e-02 1.690
R-HSA-5683057 MAPK family signaling cascades 2.211371e-02 1.655
R-HSA-9700645 ALK mutants bind TKIs 3.443088e-02 1.463
R-HSA-428543 Inactivation of CDC42 and RAC1 3.443088e-02 1.463
R-HSA-198693 AKT phosphorylates targets in the nucleus 3.443088e-02 1.463
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 3.443088e-02 1.463
R-HSA-6794362 Protein-protein interactions at synapses 3.036677e-02 1.518
R-HSA-388396 GPCR downstream signalling 2.740798e-02 1.562
R-HSA-9700206 Signaling by ALK in cancer 4.741562e-02 1.324
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.741562e-02 1.324
R-HSA-9796292 Formation of axial mesoderm 4.843216e-02 1.315
R-HSA-373760 L1CAM interactions 5.546638e-02 1.256
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 5.673734e-02 1.246
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 6.223467e-02 1.206
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 9.984762e-02 1.001
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.024770e-01 0.989
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.024770e-01 0.989
R-HSA-1855170 IPs transport between nucleus and cytosol 1.077133e-01 0.968
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.077133e-01 0.968
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.103202e-01 0.957
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 1.155117e-01 0.937
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 1.258059e-01 0.900
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 1.283611e-01 0.892
R-HSA-68962 Activation of the pre-replicative complex 9.984762e-02 1.001
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1.359828e-01 0.867
R-HSA-166208 mTORC1-mediated signalling 7.853919e-02 1.105
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 1.129197e-01 0.947
R-HSA-180910 Vpr-mediated nuclear import of PICs 1.206735e-01 0.918
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.435393e-01 0.843
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 1.050989e-01 0.978
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 1.103202e-01 0.957
R-HSA-191859 snRNP Assembly 1.779562e-01 0.750
R-HSA-194441 Metabolism of non-coding RNA 1.779562e-01 0.750
R-HSA-168325 Viral Messenger RNA Synthesis 1.827610e-01 0.738
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 9.984762e-02 1.001
R-HSA-180746 Nuclear import of Rev protein 1.129197e-01 0.947
R-HSA-168273 Influenza Viral RNA Transcription and Replication 9.088234e-02 1.042
R-HSA-381042 PERK regulates gene expression 1.155117e-01 0.937
R-HSA-177243 Interactions of Rev with host cellular proteins 1.283611e-01 0.892
R-HSA-176033 Interactions of Vpr with host cellular proteins 1.283611e-01 0.892
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.309089e-01 0.883
R-HSA-176187 Activation of ATR in response to replication stress 1.077133e-01 0.968
R-HSA-9930044 Nuclear RNA decay 1.077133e-01 0.968
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.232434e-01 0.909
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.460437e-01 0.836
R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.258059e-01 0.900
R-HSA-2980766 Nuclear Envelope Breakdown 1.731237e-01 0.762
R-HSA-6784531 tRNA processing in the nucleus 1.851532e-01 0.732
R-HSA-168255 Influenza Infection 1.138244e-01 0.944
R-HSA-3214842 HDMs demethylate histones 8.658708e-02 1.063
R-HSA-69620 Cell Cycle Checkpoints 1.947062e-01 0.711
R-HSA-376176 Signaling by ROBO receptors 1.370910e-01 0.863
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 8.122951e-02 1.090
R-HSA-6794361 Neurexins and neuroligins 1.609204e-01 0.793
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.050989e-01 0.978
R-HSA-375276 Peptide ligand-binding receptors 1.204972e-01 0.919
R-HSA-162582 Signal Transduction 9.386341e-02 1.028
R-HSA-75153 Apoptotic execution phase 1.460437e-01 0.836
R-HSA-422475 Axon guidance 8.263478e-02 1.083
R-HSA-9675108 Nervous system development 9.862155e-02 1.006
R-HSA-1266738 Developmental Biology 1.133779e-01 0.945
R-HSA-1280215 Cytokine Signaling in Immune system 9.763638e-02 1.010
R-HSA-9734767 Developmental Cell Lineages 2.000091e-01 0.699
R-HSA-9924644 Developmental Lineages of the Mammary Gland 2.087005e-01 0.680
R-HSA-5578749 Transcriptional regulation by small RNAs 2.087005e-01 0.680
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.110183e-01 0.676
R-HSA-4086398 Ca2+ pathway 2.110183e-01 0.676
R-HSA-1169408 ISG15 antiviral mechanism 2.156340e-01 0.666
R-HSA-5689603 UCH proteinases 2.179319e-01 0.662
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.315815e-01 0.635
R-HSA-141424 Amplification of signal from the kinetochores 2.405515e-01 0.619
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.405515e-01 0.619
R-HSA-156902 Peptide chain elongation 2.472116e-01 0.607
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 2.538145e-01 0.595
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.560029e-01 0.592
R-HSA-156842 Eukaryotic Translation Elongation 2.581850e-01 0.588
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.646937e-01 0.577
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.668508e-01 0.574
R-HSA-72764 Eukaryotic Translation Termination 2.668508e-01 0.574
R-HSA-72689 Formation of a pool of free 40S subunits 2.668508e-01 0.574
R-HSA-69618 Mitotic Spindle Checkpoint 2.775439e-01 0.557
R-HSA-70171 Glycolysis 2.775439e-01 0.557
R-HSA-2408557 Selenocysteine synthesis 2.796642e-01 0.553
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 2.817783e-01 0.550
R-HSA-192823 Viral mRNA Translation 2.838864e-01 0.547
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.859884e-01 0.544
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.943362e-01 0.531
R-HSA-211000 Gene Silencing by RNA 2.943362e-01 0.531
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.964081e-01 0.528
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.964081e-01 0.528
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.964081e-01 0.528
R-HSA-69002 DNA Replication Pre-Initiation 2.984742e-01 0.525
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.984742e-01 0.525
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.046367e-01 0.516
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.046367e-01 0.516
R-HSA-1483249 Inositol phosphate metabolism 3.046367e-01 0.516
R-HSA-72613 Eukaryotic Translation Initiation 3.168032e-01 0.499
R-HSA-72737 Cap-dependent Translation Initiation 3.168032e-01 0.499
R-HSA-70326 Glucose metabolism 3.188106e-01 0.496
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.208122e-01 0.494
R-HSA-68875 Mitotic Prophase 3.247982e-01 0.488
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.267826e-01 0.486
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 3.307342e-01 0.481
R-HSA-162909 Host Interactions of HIV factors 3.327016e-01 0.478
R-HSA-382551 Transport of small molecules 3.352388e-01 0.475
R-HSA-69206 G1/S Transition 3.366192e-01 0.473
R-HSA-69481 G2/M Checkpoints 3.405144e-01 0.468
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 3.424243e-01 0.465
R-HSA-9717189 Sensory perception of taste 3.501546e-01 0.456
R-HSA-9018519 Estrogen-dependent gene expression 3.615410e-01 0.442
R-HSA-3858494 Beta-catenin independent WNT signaling 3.615410e-01 0.442
R-HSA-9948299 Ribosome-associated quality control 3.652928e-01 0.437
R-HSA-381119 Unfolded Protein Response (UPR) 3.671607e-01 0.435
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.745784e-01 0.426
R-HSA-162599 Late Phase of HIV Life Cycle 3.745784e-01 0.426
R-HSA-453279 Mitotic G1 phase and G1/S transition 3.819109e-01 0.418
R-HSA-9758941 Gastrulation 3.873551e-01 0.412
R-HSA-9755511 KEAP1-NFE2L2 pathway 3.909584e-01 0.408
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 3.927523e-01 0.406
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 3.927523e-01 0.406
R-HSA-69306 DNA Replication 3.945410e-01 0.404
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.963246e-01 0.402
R-HSA-9610379 HCMV Late Events 4.016444e-01 0.396
R-HSA-162587 HIV Life Cycle 4.016444e-01 0.396
R-HSA-9711097 Cellular response to starvation 4.034075e-01 0.394
R-HSA-109581 Apoptosis 4.104091e-01 0.387
R-HSA-2467813 Separation of Sister Chromatids 4.138796e-01 0.383
R-HSA-2408522 Selenoamino acid metabolism 4.138796e-01 0.383
R-HSA-5619102 SLC transporter disorders 4.190480e-01 0.378
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 4.258698e-01 0.371
R-HSA-72306 tRNA processing 4.258698e-01 0.371
R-HSA-8868773 rRNA processing in the nucleus and cytosol 4.556103e-01 0.341
R-HSA-8953854 Metabolism of RNA 4.592628e-01 0.338
R-HSA-68877 Mitotic Prometaphase 4.636004e-01 0.334
R-HSA-9609690 HCMV Early Events 4.683393e-01 0.329
R-HSA-5357801 Programmed Cell Death 4.838413e-01 0.315
R-HSA-68882 Mitotic Anaphase 5.003828e-01 0.301
R-HSA-2555396 Mitotic Metaphase and Anaphase 5.018606e-01 0.299
R-HSA-69278 Cell Cycle, Mitotic 5.149597e-01 0.288
R-HSA-162906 HIV Infection 5.164051e-01 0.287
R-HSA-9705683 SARS-CoV-2-host interactions 5.178365e-01 0.286
R-HSA-72312 rRNA processing 5.235207e-01 0.281
R-HSA-3247509 Chromatin modifying enzymes 5.263382e-01 0.279
R-HSA-8939211 ESR-mediated signaling 5.305338e-01 0.275
R-HSA-500792 GPCR ligand binding 5.358341e-01 0.271
R-HSA-5619115 Disorders of transmembrane transporters 5.442582e-01 0.264
R-HSA-4839726 Chromatin organization 5.469555e-01 0.262
R-HSA-9609646 HCMV Infection 5.482983e-01 0.261
R-HSA-5688426 Deubiquitination 5.549542e-01 0.256
R-HSA-9711123 Cellular response to chemical stress 5.718135e-01 0.243
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.855895e-01 0.232
R-HSA-1257604 PIP3 activates AKT signaling 6.048561e-01 0.218
R-HSA-195721 Signaling by WNT 6.083697e-01 0.216
R-HSA-1643685 Disease 6.096306e-01 0.215
R-HSA-1640170 Cell Cycle 6.340830e-01 0.198
R-HSA-9694516 SARS-CoV-2 Infection 6.636274e-01 0.178
R-HSA-9006931 Signaling by Nuclear Receptors 6.774105e-01 0.169
R-HSA-212436 Generic Transcription Pathway 6.862397e-01 0.164
R-HSA-68886 M Phase 6.961464e-01 0.157
R-HSA-74160 Gene expression (Transcription) 7.054759e-01 0.152
R-HSA-168256 Immune System 7.290173e-01 0.137
R-HSA-72766 Translation 7.360831e-01 0.133
R-HSA-73857 RNA Polymerase II Transcription 7.515062e-01 0.124
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 7.559187e-01 0.122
R-HSA-6798695 Neutrophil degranulation 7.573826e-01 0.121
R-HSA-9679506 SARS-CoV Infections 8.194923e-01 0.086
R-HSA-71291 Metabolism of amino acids and derivatives 8.508898e-01 0.070
R-HSA-9824446 Viral Infection Pathways 8.574903e-01 0.067
R-HSA-597592 Post-translational protein modification 9.635073e-01 0.016
R-HSA-5663205 Infectious disease 9.665323e-01 0.015
R-HSA-9709957 Sensory Perception 9.781400e-01 0.010
R-HSA-392499 Metabolism of proteins 9.800733e-01 0.009
R-HSA-168249 Innate Immune System 9.836786e-01 0.007
R-HSA-1430728 Metabolism 9.999436e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK1CLK1 0.668 0.325 -3 0.615
CDK18CDK18 0.667 0.412 1 0.847
CDK14CDK14 0.666 0.430 1 0.839
CDK10CDK10 0.666 0.415 1 0.845
DYRK4DYRK4 0.665 0.428 1 0.839
DYRK2DYRK2 0.664 0.400 1 0.798
CDK3CDK3 0.664 0.415 1 0.849
CLK3CLK3 0.663 0.303 1 0.722
CDK7CDK7 0.662 0.385 1 0.853
SRPK1SRPK1 0.662 0.252 -3 0.634
CDK1CDK1 0.662 0.410 1 0.843
CDK13CDK13 0.661 0.391 1 0.853
CLK4CLK4 0.661 0.296 -3 0.619
HIPK2HIPK2 0.661 0.397 1 0.816
CDK17CDK17 0.661 0.410 1 0.841
CDK16CDK16 0.660 0.418 1 0.838
CDK9CDK9 0.659 0.393 1 0.856
KISKIS 0.658 0.368 1 0.841
CLK2CLK2 0.658 0.315 -3 0.594
CDK2CDK2 0.658 0.370 1 0.802
HIPK1HIPK1 0.658 0.381 1 0.799
JNK2JNK2 0.657 0.421 1 0.856
CDK19CDK19 0.657 0.372 1 0.834
NLKNLK 0.657 0.362 1 0.750
CDK12CDK12 0.657 0.386 1 0.852
DYRK1ADYRK1A 0.657 0.354 1 0.817
HIPK4HIPK4 0.656 0.260 1 0.689
CDK8CDK8 0.655 0.368 1 0.830
CDKL5CDKL5 0.655 0.166 -3 0.656
HIPK3HIPK3 0.654 0.371 1 0.789
DYRK1BDYRK1B 0.653 0.390 1 0.824
PRKD2PRKD2 0.653 0.142 -3 0.602
P38BP38B 0.653 0.389 1 0.844
CDKL1CDKL1 0.652 0.164 -3 0.655
P38AP38A 0.652 0.381 1 0.832
MAPKAPK3MAPKAPK3 0.652 0.146 -3 0.609
ICKICK 0.652 0.234 -3 0.654
SRPK2SRPK2 0.651 0.208 -3 0.598
ERK1ERK1 0.651 0.375 1 0.852
PRKD3PRKD3 0.650 0.152 -3 0.636
P38GP38G 0.649 0.403 1 0.844
PRKD1PRKD1 0.649 0.100 -3 0.650
DYRK3DYRK3 0.649 0.319 1 0.770
JNK3JNK3 0.648 0.395 1 0.860
GSK3BGSK3B 0.647 0.238 4 0.680
CAMK1BCAMK1B 0.647 0.134 -3 0.650
SBKSBK 0.647 0.214 -3 0.536
MTORMTOR 0.647 0.089 1 0.609
P90RSKP90RSK 0.646 0.119 -3 0.633
MAPKAPK2MAPKAPK2 0.646 0.128 -3 0.586
SRPK3SRPK3 0.646 0.175 -3 0.621
PKN3PKN3 0.646 0.108 -3 0.616
CDK5CDK5 0.646 0.358 1 0.837
RSK2RSK2 0.646 0.114 -3 0.640
ERK2ERK2 0.645 0.377 1 0.829
ERK5ERK5 0.645 0.168 1 0.691
PIM1PIM1 0.644 0.129 -3 0.606
NUAK2NUAK2 0.644 0.118 -3 0.622
CDK6CDK6 0.643 0.376 1 0.848
P38DP38D 0.643 0.391 1 0.846
GSK3AGSK3A 0.642 0.263 4 0.679
CAMK2DCAMK2D 0.642 0.068 -3 0.623
CDK4CDK4 0.642 0.385 1 0.845
CDC7CDC7 0.640 -0.048 1 0.533
PKN2PKN2 0.639 0.082 -3 0.620
CAMK2ACAMK2A 0.639 0.109 2 0.562
PRPKPRPK 0.639 -0.027 -1 0.583
MOSMOS 0.638 0.020 1 0.580
PIM3PIM3 0.637 0.034 -3 0.616
RSK3RSK3 0.636 0.069 -3 0.647
CAMK4CAMK4 0.636 0.064 -3 0.603
PDHK4PDHK4 0.636 -0.087 1 0.543
MOKMOK 0.636 0.277 1 0.726
CAMK2BCAMK2B 0.635 0.086 2 0.550
CHK1CHK1 0.635 0.101 -3 0.608
CAMLCKCAMLCK 0.634 0.068 -2 0.650
TSSK2TSSK2 0.634 0.092 -5 0.700
NIKNIK 0.634 0.056 -3 0.620
P70S6KBP70S6KB 0.633 0.077 -3 0.626
CAMK1GCAMK1G 0.633 0.126 -3 0.606
CAMK2GCAMK2G 0.632 -0.015 2 0.562
AKT2AKT2 0.632 0.112 -3 0.595
WNK1WNK1 0.632 0.043 -2 0.733
DAPK2DAPK2 0.632 0.038 -3 0.649
ATRATR 0.632 -0.048 1 0.481
COTCOT 0.632 -0.084 2 0.650
MSK1MSK1 0.632 0.082 -3 0.631
MSK2MSK2 0.631 0.063 -3 0.637
MAKMAK 0.631 0.264 -2 0.534
AMPKA2AMPKA2 0.631 0.078 -3 0.609
MAPKAPK5MAPKAPK5 0.631 0.078 -3 0.623
PHKG1PHKG1 0.631 0.051 -3 0.603
NDR1NDR1 0.630 0.038 -3 0.618
JNK1JNK1 0.630 0.352 1 0.859
PKN1PKN1 0.630 0.113 -3 0.619
NDR2NDR2 0.630 0.008 -3 0.603
MELKMELK 0.630 0.074 -3 0.610
AMPKA1AMPKA1 0.629 0.052 -3 0.618
PDHK1PDHK1 0.629 -0.130 1 0.513
MASTLMASTL 0.628 -0.055 -2 0.683
TSSK1TSSK1 0.628 0.068 -3 0.626
BMPR2BMPR2 0.628 -0.149 -2 0.683
CHK2CHK2 0.627 0.128 -3 0.571
PIM2PIM2 0.627 0.088 -3 0.617
CAMK1DCAMK1D 0.627 0.134 -3 0.563
RSK4RSK4 0.627 0.082 -3 0.595
MST4MST4 0.626 -0.005 2 0.619
PKACGPKACG 0.626 0.033 -2 0.577
MYLK4MYLK4 0.626 0.069 -2 0.568
NUAK1NUAK1 0.625 0.041 -3 0.604
PKCDPKCD 0.625 0.014 2 0.581
TBK1TBK1 0.625 -0.116 1 0.436
P70S6KP70S6K 0.625 0.083 -3 0.620
IKKBIKKB 0.624 -0.131 -2 0.588
CAMK1ACAMK1A 0.624 0.141 -3 0.569
RAF1RAF1 0.623 -0.154 1 0.490
SMG1SMG1 0.623 -0.007 1 0.434
PHKG2PHKG2 0.623 0.050 -3 0.608
PRP4PRP4 0.623 0.168 -3 0.465
SGK3SGK3 0.622 0.060 -3 0.625
AURCAURC 0.622 0.022 -2 0.491
LATS2LATS2 0.622 -0.017 -5 0.459
LATS1LATS1 0.622 0.032 -3 0.620
IKKEIKKE 0.621 -0.129 1 0.427
GCN2GCN2 0.621 -0.143 2 0.582
DRAK1DRAK1 0.621 0.017 1 0.495
DNAPKDNAPK 0.621 -0.007 1 0.415
MLK1MLK1 0.621 -0.105 2 0.617
PRKXPRKX 0.621 0.090 -3 0.544
DCAMKL1DCAMKL1 0.621 0.087 -3 0.598
DCAMKL2DCAMKL2 0.620 0.073 -3 0.610
BRSK2BRSK2 0.620 0.021 -3 0.607
RIPK3RIPK3 0.620 -0.063 3 0.578
BRSK1BRSK1 0.620 0.033 -3 0.614
GRK6GRK6 0.620 -0.046 1 0.487
PAK6PAK6 0.620 0.010 -2 0.542
GRK5GRK5 0.619 -0.127 -3 0.561
SMMLCKSMMLCK 0.619 0.066 -3 0.646
MNK1MNK1 0.619 0.028 -2 0.633
QIKQIK 0.619 -0.025 -3 0.616
PKACAPKACA 0.618 0.065 -2 0.467
PKCHPKCH 0.618 0.009 2 0.545
ERK7ERK7 0.618 0.106 2 0.395
MNK2MNK2 0.618 -0.001 -2 0.629
AURBAURB 0.618 0.014 -2 0.488
SKMLCKSKMLCK 0.617 -0.039 -2 0.659
WNK3WNK3 0.617 -0.118 1 0.467
MEK1MEK1 0.617 -0.066 2 0.644
BUB1BUB1 0.617 0.107 -5 0.645
PKG2PKG2 0.617 0.026 -2 0.513
DSTYKDSTYK 0.616 -0.168 2 0.670
SGK1SGK1 0.616 0.110 -3 0.565
PASKPASK 0.616 0.073 -3 0.631
NIM1NIM1 0.616 -0.039 3 0.574
AKT1AKT1 0.616 0.070 -3 0.590
PKACBPKACB 0.616 0.048 -2 0.499
ATMATM 0.616 -0.061 1 0.422
DLKDLK 0.615 -0.127 1 0.484
PKCEPKCE 0.615 0.068 2 0.531
PKCBPKCB 0.615 -0.002 2 0.557
CHAK2CHAK2 0.615 -0.093 -1 0.502
GRK1GRK1 0.615 -0.036 -2 0.628
IRE1IRE1 0.614 -0.074 1 0.433
MARK4MARK4 0.614 -0.072 4 0.547
MLK2MLK2 0.614 -0.124 2 0.642
SNRKSNRK 0.614 -0.021 2 0.576
RIPK1RIPK1 0.614 -0.105 1 0.466
PKCAPKCA 0.614 -0.025 2 0.549
TGFBR2TGFBR2 0.614 -0.114 -2 0.533
SIKSIK 0.613 0.002 -3 0.594
BCKDKBCKDK 0.613 -0.148 -1 0.495
ULK2ULK2 0.613 -0.205 2 0.597
PKCIPKCI 0.613 0.020 2 0.553
PKCZPKCZ 0.612 -0.041 2 0.596
PKCGPKCG 0.611 -0.033 2 0.547
NEK7NEK7 0.611 -0.185 -3 0.560
PAK3PAK3 0.611 -0.055 -2 0.601
VRK2VRK2 0.611 -0.052 1 0.556
ANKRD3ANKRD3 0.611 -0.143 1 0.512
AKT3AKT3 0.611 0.089 -3 0.570
AURAAURA 0.611 -0.003 -2 0.459
YSK4YSK4 0.611 -0.109 1 0.446
PAK1PAK1 0.610 -0.027 -2 0.594
PKCTPKCT 0.610 0.000 2 0.555
PAK2PAK2 0.610 -0.035 -2 0.586
CHAK1CHAK1 0.609 -0.088 2 0.647
NEK9NEK9 0.609 -0.165 2 0.626
NEK6NEK6 0.608 -0.150 -2 0.644
PKRPKR 0.608 -0.083 1 0.483
HUNKHUNK 0.608 -0.153 2 0.597
WNK4WNK4 0.608 -0.014 -2 0.739
PINK1PINK1 0.608 -0.023 1 0.607
CRIKCRIK 0.607 0.127 -3 0.596
ALK4ALK4 0.607 -0.085 -2 0.578
QSKQSK 0.607 -0.042 4 0.530
GRK7GRK7 0.607 -0.034 1 0.482
MEK5MEK5 0.607 -0.098 2 0.646
MST3MST3 0.607 -0.013 2 0.629
ULK1ULK1 0.607 -0.179 -3 0.514
MRCKAMRCKA 0.607 0.080 -3 0.594
SSTKSSTK 0.606 0.037 4 0.519
MLK3MLK3 0.606 -0.101 2 0.556
IRE2IRE2 0.606 -0.088 2 0.532
ACVR2AACVR2A 0.606 -0.090 -2 0.538
PLK3PLK3 0.606 -0.054 2 0.565
NEK2NEK2 0.605 -0.125 2 0.623
TGFBR1TGFBR1 0.604 -0.078 -2 0.547
BMPR1BBMPR1B 0.604 -0.071 1 0.474
GAKGAK 0.604 0.030 1 0.546
HRIHRI 0.604 -0.104 -2 0.624
DAPK1DAPK1 0.604 0.053 -3 0.615
PDK1PDK1 0.604 0.018 1 0.557
NEK11NEK11 0.603 -0.061 1 0.495
PLK1PLK1 0.603 -0.101 -2 0.567
FAM20CFAM20C 0.602 -0.034 2 0.440
GRK2GRK2 0.602 -0.068 -2 0.506
GRK4GRK4 0.602 -0.159 -2 0.617
MARK3MARK3 0.602 -0.037 4 0.496
CK2A1CK2A1 0.601 0.022 1 0.488
MARK1MARK1 0.601 -0.060 4 0.512
IKKAIKKA 0.600 -0.167 -2 0.573
MPSK1MPSK1 0.600 -0.042 1 0.500
CK2A2CK2A2 0.600 -0.005 1 0.500
MRCKBMRCKB 0.600 0.068 -3 0.596
ALK2ALK2 0.600 -0.090 -2 0.551
ACVR2BACVR2B 0.599 -0.102 -2 0.539
TTBK2TTBK2 0.599 -0.185 2 0.511
DMPK1DMPK1 0.599 0.097 -3 0.596
MARK2MARK2 0.599 -0.064 4 0.443
MEKK3MEKK3 0.599 -0.116 1 0.467
PAK5PAK5 0.599 -0.026 -2 0.509
TAO2TAO2 0.598 -0.035 2 0.631
ZAKZAK 0.598 -0.132 1 0.449
IRAK4IRAK4 0.597 -0.099 1 0.431
LOKLOK 0.596 -0.016 -2 0.681
MLK4MLK4 0.596 -0.148 2 0.545
DAPK3DAPK3 0.596 0.022 -3 0.607
PERKPERK 0.596 -0.152 -2 0.609
TAO3TAO3 0.596 -0.078 1 0.490
HPK1HPK1 0.595 -0.027 1 0.457
LRRK2LRRK2 0.595 -0.021 2 0.641
CK1DCK1D 0.595 -0.054 -3 0.269
CK1ECK1E 0.594 -0.074 -3 0.321
BIKEBIKE 0.594 0.051 1 0.489
IRAK1IRAK1 0.594 -0.143 -1 0.518
PBKPBK 0.594 -0.002 1 0.508
PKG1PKG1 0.593 0.015 -2 0.467
PDHK3_TYRPDHK3_TYR 0.593 0.045 4 0.669
RIPK2RIPK2 0.592 -0.101 1 0.445
PAK4PAK4 0.592 -0.026 -2 0.505
EEF2KEEF2K 0.592 -0.044 3 0.654
TTBK1TTBK1 0.592 -0.119 2 0.448
MEKK1MEKK1 0.592 -0.186 1 0.460
MEKK2MEKK2 0.591 -0.163 2 0.617
HGKHGK 0.591 -0.064 3 0.688
CK1A2CK1A2 0.591 -0.061 -3 0.282
MEKK6MEKK6 0.591 -0.082 1 0.440
GCKGCK 0.591 -0.074 1 0.462
ROCK2ROCK2 0.590 0.043 -3 0.606
BMPR1ABMPR1A 0.590 -0.083 1 0.466
TESK1_TYRTESK1_TYR 0.590 0.014 3 0.694
PKMYT1_TYRPKMYT1_TYR 0.590 0.038 3 0.663
TNIKTNIK 0.590 -0.041 3 0.713
LIMK2_TYRLIMK2_TYR 0.590 0.073 -3 0.599
GRK3GRK3 0.589 -0.072 -2 0.461
BRAFBRAF 0.589 -0.187 -4 0.448
AAK1AAK1 0.589 0.074 1 0.450
MAP2K4_TYRMAP2K4_TYR 0.589 -0.030 -1 0.581
TAK1TAK1 0.589 -0.095 1 0.457
MAP3K15MAP3K15 0.589 -0.099 1 0.462
PLK4PLK4 0.588 -0.137 2 0.474
HASPINHASPIN 0.588 0.007 -1 0.378
MINKMINK 0.588 -0.091 1 0.439
MST2MST2 0.588 -0.122 1 0.452
SLKSLK 0.587 -0.057 -2 0.641
CAMKK2CAMKK2 0.587 -0.142 -2 0.628
NEK5NEK5 0.587 -0.180 1 0.464
NEK8NEK8 0.587 -0.160 2 0.627
MAP2K7_TYRMAP2K7_TYR 0.587 -0.060 2 0.659
PINK1_TYRPINK1_TYR 0.586 -0.048 1 0.538
BMPR2_TYRBMPR2_TYR 0.586 0.024 -1 0.583
MEK2MEK2 0.586 -0.136 2 0.623
TLK2TLK2 0.586 -0.187 1 0.392
PDHK4_TYRPDHK4_TYR 0.585 -0.011 2 0.685
NEK4NEK4 0.585 -0.136 1 0.428
KHS2KHS2 0.585 -0.035 1 0.455
MAP2K6_TYRMAP2K6_TYR 0.585 -0.027 -1 0.579
PLK2PLK2 0.584 -0.027 -3 0.585
CAMKK1CAMKK1 0.584 -0.194 -2 0.620
KHS1KHS1 0.584 -0.063 1 0.442
NEK1NEK1 0.582 -0.115 1 0.445
NEK3NEK3 0.581 -0.096 1 0.451
TLK1TLK1 0.581 -0.186 -2 0.569
ROCK1ROCK1 0.581 0.032 -3 0.595
NEK10_TYRNEK10_TYR 0.581 0.001 1 0.425
MST1MST1 0.580 -0.120 1 0.438
LIMK1_TYRLIMK1_TYR 0.580 -0.033 2 0.648
YSK1YSK1 0.580 -0.092 2 0.610
CK1G1CK1G1 0.579 -0.110 -3 0.307
LKB1LKB1 0.579 -0.166 -3 0.539
STK33STK33 0.578 -0.102 2 0.475
PDHK1_TYRPDHK1_TYR 0.578 -0.104 -1 0.581
TAO1TAO1 0.576 -0.047 1 0.429
RETRET 0.576 -0.084 1 0.474
EPHB4EPHB4 0.576 -0.057 -1 0.569
TXKTXK 0.575 -0.016 1 0.507
ALPHAK3ALPHAK3 0.575 -0.036 -1 0.489
MST1RMST1R 0.574 -0.074 3 0.642
EPHA6EPHA6 0.573 -0.067 -1 0.578
DDR1DDR1 0.573 -0.062 4 0.561
MYO3BMYO3B 0.573 -0.068 2 0.620
TNK2TNK2 0.573 -0.044 3 0.619
VRK1VRK1 0.572 -0.177 2 0.593
TYRO3TYRO3 0.572 -0.109 3 0.616
JAK2JAK2 0.571 -0.128 1 0.483
JAK1JAK1 0.571 -0.060 1 0.447
TYK2TYK2 0.570 -0.183 1 0.462
JAK3JAK3 0.570 -0.083 1 0.483
AXLAXL 0.570 -0.060 3 0.624
WEE1_TYRWEE1_TYR 0.570 -0.041 -1 0.527
TEKTEK 0.569 -0.016 3 0.566
EPHA4EPHA4 0.569 -0.052 2 0.566
TNNI3K_TYRTNNI3K_TYR 0.569 -0.055 1 0.469
SRMSSRMS 0.569 -0.086 1 0.472
OSR1OSR1 0.569 -0.096 2 0.628
HCKHCK 0.568 -0.091 -1 0.643
LCKLCK 0.568 -0.055 -1 0.645
YES1YES1 0.567 -0.090 -1 0.605
EPHB1EPHB1 0.567 -0.082 1 0.468
FGRFGR 0.567 -0.139 1 0.487
ASK1ASK1 0.567 -0.118 1 0.461
CSF1RCSF1R 0.567 -0.110 3 0.626
ROS1ROS1 0.567 -0.150 3 0.578
MERTKMERTK 0.566 -0.069 3 0.620
EPHB3EPHB3 0.566 -0.079 -1 0.573
ABL2ABL2 0.566 -0.092 -1 0.545
ITKITK 0.566 -0.072 -1 0.617
BLKBLK 0.566 -0.043 -1 0.622
MYO3AMYO3A 0.565 -0.094 1 0.423
YANK3YANK3 0.565 -0.066 2 0.271
ABL1ABL1 0.565 -0.095 -1 0.544
FGFR2FGFR2 0.564 -0.077 3 0.625
EPHA1EPHA1 0.563 -0.054 3 0.613
PTK2BPTK2B 0.563 -0.045 -1 0.566
DDR2DDR2 0.563 0.007 3 0.570
BTKBTK 0.563 -0.114 -1 0.610
TECTEC 0.562 -0.080 -1 0.563
EPHA7EPHA7 0.562 -0.064 2 0.573
EPHA3EPHA3 0.562 -0.074 2 0.547
FERFER 0.562 -0.180 1 0.500
INSRRINSRR 0.562 -0.122 3 0.561
FGFR1FGFR1 0.561 -0.088 3 0.592
FYNFYN 0.561 -0.045 -1 0.636
EPHB2EPHB2 0.561 -0.098 -1 0.560
TNK1TNK1 0.561 -0.098 3 0.587
KDRKDR 0.561 -0.086 3 0.606
BMXBMX 0.560 -0.066 -1 0.550
PDGFRAPDGFRA 0.560 -0.137 3 0.624
FLT1FLT1 0.560 -0.081 -1 0.538
TTKTTK 0.559 -0.138 -2 0.570
PDGFRBPDGFRB 0.559 -0.167 3 0.624
KITKIT 0.559 -0.126 3 0.631
STLK3STLK3 0.558 -0.129 1 0.410
EPHA5EPHA5 0.557 -0.066 2 0.564
LYNLYN 0.557 -0.095 3 0.536
PTK6PTK6 0.556 -0.165 -1 0.553
ERBB2ERBB2 0.556 -0.124 1 0.451
CK1ACK1A 0.555 -0.088 -3 0.206
PTK2PTK2 0.554 -0.010 -1 0.555
FLT3FLT3 0.554 -0.166 3 0.610
FRKFRK 0.554 -0.101 -1 0.625
EPHA8EPHA8 0.553 -0.073 -1 0.561
FGFR3FGFR3 0.553 -0.100 3 0.610
LTKLTK 0.552 -0.142 3 0.560
CSKCSK 0.552 -0.105 2 0.580
FLT4FLT4 0.552 -0.126 3 0.589
NTRK2NTRK2 0.551 -0.176 3 0.597
METMET 0.551 -0.129 3 0.633
NTRK1NTRK1 0.551 -0.190 -1 0.536
NTRK3NTRK3 0.550 -0.146 -1 0.512
SRCSRC 0.550 -0.102 -1 0.605
ALKALK 0.548 -0.177 3 0.522
EPHA2EPHA2 0.547 -0.068 -1 0.540
SYKSYK 0.546 -0.053 -1 0.550
MUSKMUSK 0.544 -0.113 1 0.373
MATKMATK 0.543 -0.120 -1 0.434
EGFREGFR 0.543 -0.109 1 0.394
INSRINSR 0.542 -0.184 3 0.544
CK1G3CK1G3 0.540 -0.096 -3 0.171
FGFR4FGFR4 0.539 -0.126 -1 0.495
YANK2YANK2 0.538 -0.087 2 0.286
IGF1RIGF1R 0.532 -0.154 3 0.492
ERBB4ERBB4 0.531 -0.091 1 0.384
FESFES 0.529 -0.134 -1 0.514
ZAP70ZAP70 0.526 -0.071 -1 0.480
CK1G2CK1G2 0.526 -0.072 -3 0.236