Motif 537 (n=165)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S515 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A0A0C4DH73 | IGKV1-12 | S32 | ochoa | Immunoglobulin kappa variable 1-12 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| A0FGR8 | ESYT2 | S739 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A0JNW5 | BLTP3B | S887 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A6NKT7 | RGPD3 | S1267 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00291 | HIP1 | S305 | ochoa | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}. |
| O14490 | DLGAP1 | S362 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14578 | CIT | S436 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14639 | ABLIM1 | S355 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14639 | ABLIM1 | S358 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14713 | ITGB1BP1 | S37 | ochoa | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O14715 | RGPD8 | S1266 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14980 | XPO1 | S387 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15164 | TRIM24 | S663 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15440 | ABCC5 | S505 | ochoa | ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). {ECO:0000250|UniProtKB:Q9R1X5, ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:10893247, ECO:0000269|PubMed:12435799, ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538, ECO:0000269|PubMed:15899835, ECO:0000269|PubMed:17229149, ECO:0000269|PubMed:24836561, ECO:0000269|PubMed:25964343, ECO:0000269|PubMed:26515061}. |
| O15533 | TAPBP | S359 | ochoa | Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) | Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848, ECO:0000269|PubMed:12582157, ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:26611325}. |
| O43298 | ZBTB43 | S138 | ochoa | Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) | May be involved in transcriptional regulation. |
| O60260 | PRKN | S127 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
| O60293 | ZFC3H1 | S651 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60315 | ZEB2 | S356 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O75061 | DNAJC6 | S566 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75113 | N4BP1 | S331 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75122 | CLASP2 | S316 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75995 | SASH3 | S149 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94921 | CDK14 | S122 | ochoa | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| O95251 | KAT7 | S53 | ochoa|psp | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| P00519 | ABL1 | S679 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P01611 | IGKV1D-12 | S32 | ochoa | Immunoglobulin kappa variable 1D-12 (Ig kappa chain V-I region Wes) | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| P04350 | TUBB4A | S168 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | S168 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DJD0 | RGPD1 | S1251 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1259 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13804 | ETFA | S185 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P14859 | POU2F1 | S81 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S88 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S366 | ochoa | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P15336 | ATF2 | S310 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P17812 | CTPS1 | S571 | ochoa|psp | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P37275 | ZEB1 | S315 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P41970 | ELK3 | S243 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P42166 | TMPO | S366 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P46939 | UTRN | S830 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P47712 | PLA2G4A | S727 | ochoa|psp | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P49790 | NUP153 | S185 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S2242 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P55957 | BID | S67 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P68371 | TUBB4B | S168 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78362 | SRPK2 | S497 | ochoa|psp | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| P98082 | DAB2 | S467 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q00537 | CDK17 | S83 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q00587 | CDC42EP1 | S73 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q02880 | TOP2B | S1457 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q03188 | CENPC | S55 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04656 | ATP7A | S266 | ochoa | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04656 | ATP7A | S1476 | psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q06455 | RUNX1T1 | S413 | ochoa | Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| Q07157 | TJP1 | S280 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08174 | PCDH1 | S1014 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q09666 | AHNAK | S5186 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S786 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12965 | MYO1E | S1005 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13315 | ATM | S1881 | ochoa | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13509 | TUBB3 | S168 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13523 | PRP4K | S565 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13615 | MTMR3 | S909 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13625 | TP53BP2 | S572 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14524 | SCN5A | S460 | ochoa|psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q15398 | DLGAP5 | S630 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15678 | PTPN14 | S534 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16236 | NFE2L2 | S347 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
| Q53HC9 | EIPR1 | S307 | ochoa | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). {ECO:0000250|UniProtKB:Q5PPK9, ECO:0000269|PubMed:27440922}. |
| Q5JSZ5 | PRRC2B | S222 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T1V6 | DDX59 | S156 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5VT52 | RPRD2 | S765 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q641Q2 | WASHC2A | S700 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q674R7 | ATG9B | S867 | ochoa | Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}. |
| Q6H8Q1 | ABLIM2 | S285 | ochoa | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| Q6IAA8 | LAMTOR1 | S113 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6JBY9 | RCSD1 | S123 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6P0Q8 | MAST2 | S281 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6R327 | RICTOR | S1031 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6WCQ1 | MPRIP | S220 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6Y7W6 | GIGYF2 | S26 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZMT1 | STAC2 | S224 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
| Q76L83 | ASXL2 | S142 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L1W4 | LRRC8D | S242 | ochoa | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). {ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:32415200, ECO:0000269|PubMed:33171122}. |
| Q7Z3J3 | RGPD4 | S1267 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K3 | POGZ | S254 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z478 | DHX29 | S71 | ochoa | ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) | ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000255|HAMAP-Rule:MF_03068, ECO:0000269|PubMed:19109895, ECO:0000269|PubMed:23706745}. |
| Q7Z6E9 | RBBP6 | S1273 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86W56 | PARG | S133 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86WB0 | ZC3HC1 | S58 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86XL3 | ANKLE2 | S264 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YV5 | PRAG1 | S863 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IWS0 | PHF6 | Y195 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IZ21 | PHACTR4 | S150 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N3U4 | STAG2 | S1061 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8N6H7 | ARFGAP2 | S315 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N8Z6 | DCBLD1 | S636 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8N9M5 | TMEM102 | S214 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8NCF5 | NFATC2IP | Y164 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8ND24 | RNF214 | S497 | ochoa | RING finger protein 214 | None |
| Q8NEM2 | SHCBP1 | S47 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEY1 | NAV1 | S308 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFC6 | BOD1L1 | S1286 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHM5 | KDM2B | S910 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TBZ3 | WDR20 | S360 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TD16 | BICD2 | S611 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TF76 | HASPIN | S143 | ochoa|psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WVM7 | STAG1 | S1065 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WYQ5 | DGCR8 | S373 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92585 | MAML1 | S286 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92614 | MYO18A | S160 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q93074 | MED12 | S555 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96F24 | NRBF2 | S116 | ochoa | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q96F86 | EDC3 | S164 | ochoa | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96JK2 | DCAF5 | S464 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96PE2 | ARHGEF17 | S379 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PK6 | RBM14 | S623 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96R06 | SPAG5 | S39 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96SK2 | TMEM209 | S174 | ochoa | Transmembrane protein 209 | Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}. |
| Q99618 | CDCA3 | S168 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99666 | RGPD5 | S1266 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99808 | SLC29A1 | S269 | ochoa | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BXB4 | OSBPL11 | S177 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9C0B0 | UNK | S574 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0B5 | ZDHHC5 | S639 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0D0 | PHACTR1 | S186 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0D6 | FHDC1 | S660 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H0D6 | XRN2 | S451 | ochoa | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Q9H334 | FOXP1 | S621 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H3Q1 | CDC42EP4 | S73 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4Z3 | PCIF1 | S26 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H6K1 | ILRUN | S268 | ochoa | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9H6U6 | BCAS3 | S157 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H6U6 | BCAS3 | S896 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H7M9 | VSIR | S283 | ochoa | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}. |
| Q9H9C1 | VIPAS39 | S96 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9HC35 | EML4 | S891 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCS5 | EPB41L4A | S614 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NQ86 | TRIM36 | S76 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NZJ4 | SACS | S4260 | ochoa | Sacsin (DnaJ homolog subfamily C member 29) | Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. {ECO:0000269|PubMed:19208651}. |
| Q9P243 | ZFAT | S643 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P2B4 | CTTNBP2NL | S484 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9P2Y5 | UVRAG | S525 | ochoa | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UDT6 | CLIP2 | S173 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9ULG1 | INO80 | S1512 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9ULK2 | ATXN7L1 | S839 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9UPQ0 | LIMCH1 | S188 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQR1 | ZNF148 | S661 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y266 | NUDC | S277 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y294 | ASF1A | S175 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y2H5 | PLEKHA6 | S455 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y3P9 | RABGAP1 | S504 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y446 | PKP3 | S199 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4F3 | MARF1 | S953 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y520 | PRRC2C | S920 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y676 | MRPS18B | S45 | ochoa | Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b) | None |
| Q9Y6Q9 | NCOA3 | S863 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6Y8 | SEC23IP | S740 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q7Z460 | CLASP1 | S548 | Sugiyama | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| P23443 | RPS6KB1 | S78 | Sugiyama | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| Q8N6T3 | ARFGAP1 | S273 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8WWM7 | ATXN2L | S275 | Sugiyama | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8TD08 | MAPK15 | S353 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.168578e-07 | 6.287 |
| R-HSA-68877 | Mitotic Prometaphase | 1.125020e-06 | 5.949 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.517325e-06 | 5.819 |
| R-HSA-68882 | Mitotic Anaphase | 3.589926e-06 | 5.445 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.756009e-06 | 5.425 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.758151e-06 | 5.058 |
| R-HSA-68886 | M Phase | 1.642257e-05 | 4.785 |
| R-HSA-1632852 | Macroautophagy | 9.089394e-05 | 4.041 |
| R-HSA-9612973 | Autophagy | 1.857832e-04 | 3.731 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 2.177891e-04 | 3.662 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.163972e-04 | 3.500 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.003956e-04 | 3.398 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.207416e-04 | 3.283 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 5.834950e-04 | 3.234 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.666138e-04 | 3.115 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.666138e-04 | 3.115 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 8.135896e-04 | 3.090 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.479382e-03 | 2.830 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.479382e-03 | 2.830 |
| R-HSA-1640170 | Cell Cycle | 1.665132e-03 | 2.779 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.777180e-03 | 2.750 |
| R-HSA-9646399 | Aggrephagy | 2.124819e-03 | 2.673 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.099977e-03 | 2.678 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.379861e-03 | 2.623 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.006334e-03 | 2.522 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.926318e-03 | 2.534 |
| R-HSA-190828 | Gap junction trafficking | 3.048327e-03 | 2.516 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.454570e-03 | 2.462 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 3.830782e-03 | 2.417 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.717408e-03 | 2.430 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.540801e-03 | 2.343 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 4.812610e-03 | 2.318 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.985829e-03 | 2.302 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.185801e-03 | 2.285 |
| R-HSA-9663891 | Selective autophagy | 5.185801e-03 | 2.285 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 5.897754e-03 | 2.229 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 7.023780e-03 | 2.153 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 8.202263e-03 | 2.086 |
| R-HSA-9700645 | ALK mutants bind TKIs | 8.368354e-03 | 2.077 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.987659e-03 | 2.046 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.987659e-03 | 2.046 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.832433e-03 | 2.054 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 9.749090e-03 | 2.011 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.033494e-02 | 1.986 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.017590e-02 | 1.992 |
| R-HSA-9832991 | Formation of the posterior neural plate | 1.122370e-02 | 1.950 |
| R-HSA-190861 | Gap junction assembly | 1.163169e-02 | 1.934 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.396895e-02 | 1.855 |
| R-HSA-380287 | Centrosome maturation | 1.513825e-02 | 1.820 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.488596e-02 | 1.827 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.278994e-02 | 1.893 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.513825e-02 | 1.820 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.346155e-02 | 1.871 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.668664e-02 | 1.778 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.700504e-02 | 1.769 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.860407e-02 | 1.730 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.115519e-02 | 1.675 |
| R-HSA-199991 | Membrane Trafficking | 2.040710e-02 | 1.690 |
| R-HSA-9823739 | Formation of the anterior neural plate | 1.992715e-02 | 1.701 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.992715e-02 | 1.701 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.279085e-02 | 1.642 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.506051e-02 | 1.601 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 2.235229e-02 | 1.651 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.398946e-02 | 1.620 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 2.235229e-02 | 1.651 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.391099e-02 | 1.621 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.423828e-02 | 1.615 |
| R-HSA-437239 | Recycling pathway of L1 | 2.506051e-02 | 1.601 |
| R-HSA-5620924 | Intraflagellar transport | 2.623937e-02 | 1.581 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.658752e-02 | 1.575 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.672004e-02 | 1.573 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.835915e-02 | 1.547 |
| R-HSA-391251 | Protein folding | 2.934880e-02 | 1.532 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.079583e-02 | 1.512 |
| R-HSA-69275 | G2/M Transition | 2.995769e-02 | 1.523 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.118765e-02 | 1.506 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.835915e-02 | 1.547 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.530872e-02 | 1.452 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.795879e-02 | 1.421 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.816022e-02 | 1.418 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.975273e-02 | 1.401 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.052707e-02 | 1.392 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.052707e-02 | 1.392 |
| R-HSA-983189 | Kinesins | 4.265100e-02 | 1.370 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 4.420764e-02 | 1.355 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.578554e-02 | 1.339 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.578554e-02 | 1.339 |
| R-HSA-9707616 | Heme signaling | 4.578554e-02 | 1.339 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.680087e-02 | 1.330 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.706578e-02 | 1.327 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.706578e-02 | 1.327 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.584976e-02 | 1.253 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 6.557703e-02 | 1.183 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 6.322618e-02 | 1.199 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 6.630815e-02 | 1.178 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 6.630815e-02 | 1.178 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 7.261808e-02 | 1.139 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 7.261808e-02 | 1.139 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 7.584312e-02 | 1.120 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 7.261808e-02 | 1.139 |
| R-HSA-191650 | Regulation of gap junction activity | 6.557703e-02 | 1.183 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.557703e-02 | 1.183 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 7.584312e-02 | 1.120 |
| R-HSA-9729555 | Sensory perception of sour taste | 6.557703e-02 | 1.183 |
| R-HSA-9930044 | Nuclear RNA decay | 7.261808e-02 | 1.139 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 6.557703e-02 | 1.183 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 7.261808e-02 | 1.139 |
| R-HSA-114452 | Activation of BH3-only proteins | 6.322618e-02 | 1.199 |
| R-HSA-8939211 | ESR-mediated signaling | 7.302205e-02 | 1.137 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.322618e-02 | 1.199 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.124407e-02 | 1.213 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.497059e-02 | 1.187 |
| R-HSA-373760 | L1CAM interactions | 6.109199e-02 | 1.214 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 7.608287e-02 | 1.119 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 7.608287e-02 | 1.119 |
| R-HSA-9833482 | PKR-mediated signaling | 7.880522e-02 | 1.103 |
| R-HSA-180746 | Nuclear import of Rev protein | 7.911296e-02 | 1.102 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.169444e-01 | 0.932 |
| R-HSA-196025 | Formation of annular gap junctions | 1.169444e-01 | 0.932 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.268758e-01 | 0.897 |
| R-HSA-190873 | Gap junction degradation | 1.268758e-01 | 0.897 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.560083e-01 | 0.807 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.655027e-01 | 0.781 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.748909e-01 | 0.757 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.242620e-02 | 1.084 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 9.608601e-02 | 1.017 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 9.959610e-02 | 1.002 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.377313e-01 | 0.624 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.714786e-01 | 0.566 |
| R-HSA-1221632 | Meiotic synapsis | 1.519368e-01 | 0.818 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.958101e-01 | 0.529 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.000995e-01 | 0.699 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.539107e-01 | 0.595 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.914141e-01 | 0.535 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 2.997278e-01 | 0.523 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.705858e-01 | 0.568 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.748909e-01 | 0.757 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.547949e-01 | 0.594 |
| R-HSA-9664873 | Pexophagy | 1.366961e-01 | 0.864 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.116090e-01 | 0.674 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.116090e-01 | 0.674 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.757496e-01 | 0.755 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.116090e-01 | 0.674 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 1.960114e-01 | 0.708 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.331081e-01 | 0.632 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.655027e-01 | 0.781 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.083053e-01 | 0.681 |
| R-HSA-1500620 | Meiosis | 8.940637e-02 | 1.049 |
| R-HSA-165159 | MTOR signalling | 1.103346e-01 | 0.957 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.037396e-01 | 0.517 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.109194e-01 | 0.955 |
| R-HSA-5689877 | Josephin domain DUBs | 1.366961e-01 | 0.864 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.366961e-01 | 0.864 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 8.917739e-02 | 1.050 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.714786e-01 | 0.566 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.193333e-01 | 0.496 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.878686e-01 | 0.726 |
| R-HSA-9664407 | Parasite infection | 2.622496e-01 | 0.581 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.622496e-01 | 0.581 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.622496e-01 | 0.581 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.319152e-01 | 0.880 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.572427e-01 | 0.590 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.069007e-01 | 0.971 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.169444e-01 | 0.932 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.268758e-01 | 0.897 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.560083e-01 | 0.807 |
| R-HSA-1483115 | Hydrolysis of LPC | 1.841740e-01 | 0.735 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.757496e-01 | 0.755 |
| R-HSA-191859 | snRNP Assembly | 1.757496e-01 | 0.755 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.838155e-01 | 0.736 |
| R-HSA-5617833 | Cilium Assembly | 8.987341e-02 | 1.046 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.652817e-01 | 0.576 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.268758e-01 | 0.897 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.841740e-01 | 0.735 |
| R-HSA-525793 | Myogenesis | 3.037396e-01 | 0.517 |
| R-HSA-5689603 | UCH proteinases | 2.455807e-01 | 0.610 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.797755e-01 | 0.745 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.067216e-01 | 0.972 |
| R-HSA-389542 | NADPH regeneration | 9.674341e-02 | 1.014 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.933532e-01 | 0.714 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.024297e-01 | 0.694 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 9.959610e-02 | 1.002 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.031417e-01 | 0.987 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.958101e-01 | 0.529 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 3.115804e-01 | 0.506 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.115804e-01 | 0.506 |
| R-HSA-9609690 | HCMV Early Events | 9.831240e-02 | 1.007 |
| R-HSA-2262752 | Cellular responses to stress | 1.986277e-01 | 0.702 |
| R-HSA-1474165 | Reproduction | 2.292534e-01 | 0.640 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.268758e-01 | 0.897 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.797755e-01 | 0.745 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.637645e-01 | 0.786 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.695519e-01 | 0.771 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.464065e-01 | 0.834 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.560083e-01 | 0.807 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.933532e-01 | 0.714 |
| R-HSA-200425 | Carnitine shuttle | 2.796806e-01 | 0.553 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.757496e-01 | 0.755 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.289590e-01 | 0.640 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.889395e-01 | 0.724 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.074375e-01 | 0.512 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.193333e-01 | 0.496 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.057963e-01 | 0.687 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.024297e-01 | 0.694 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.206771e-01 | 0.656 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.933532e-01 | 0.714 |
| R-HSA-9845576 | Glycosphingolipid transport | 8.578146e-02 | 1.067 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 9.608601e-02 | 1.017 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.290543e-01 | 0.640 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 2.463111e-01 | 0.609 |
| R-HSA-9755088 | Ribavirin ADME | 2.631837e-01 | 0.580 |
| R-HSA-9609646 | HCMV Infection | 1.921014e-01 | 0.716 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.662975e-01 | 0.779 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.289590e-01 | 0.640 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.202792e-01 | 0.657 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.877907e-01 | 0.541 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.637645e-01 | 0.786 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.037396e-01 | 0.517 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.878686e-01 | 0.726 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.370779e-01 | 0.863 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.578146e-02 | 1.067 |
| R-HSA-70171 | Glycolysis | 1.319711e-01 | 0.880 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 2.290543e-01 | 0.640 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.958101e-01 | 0.529 |
| R-HSA-3214842 | HDMs demethylate histones | 2.958101e-01 | 0.529 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.960114e-01 | 0.708 |
| R-HSA-68875 | Mitotic Prophase | 1.942872e-01 | 0.712 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 9.608601e-02 | 1.017 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.290543e-01 | 0.640 |
| R-HSA-9748787 | Azathioprine ADME | 1.402915e-01 | 0.853 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.115804e-01 | 0.506 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.830884e-01 | 0.548 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.714786e-01 | 0.566 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.037396e-01 | 0.517 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.017815e-01 | 0.992 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.169444e-01 | 0.932 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.748909e-01 | 0.757 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 2.547949e-01 | 0.594 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.830884e-01 | 0.548 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.553228e-01 | 0.809 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.139794e-01 | 0.943 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.372618e-01 | 0.625 |
| R-HSA-1483255 | PI Metabolism | 1.370779e-01 | 0.863 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.713587e-01 | 0.566 |
| R-HSA-74160 | Gene expression (Transcription) | 3.175062e-01 | 0.498 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 1.841740e-01 | 0.735 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.290543e-01 | 0.640 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.796806e-01 | 0.553 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.240981e-01 | 0.906 |
| R-HSA-5357801 | Programmed Cell Death | 2.509554e-01 | 0.600 |
| R-HSA-70326 | Glucose metabolism | 1.857659e-01 | 0.731 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.083739e-01 | 0.511 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.667628e-01 | 0.574 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.366961e-01 | 0.864 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.377313e-01 | 0.624 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.782360e-01 | 0.749 |
| R-HSA-3371556 | Cellular response to heat stress | 1.971493e-01 | 0.705 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.367732e-01 | 0.626 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.539107e-01 | 0.595 |
| R-HSA-8941326 | RUNX2 regulates bone development | 8.578146e-02 | 1.067 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.319711e-01 | 0.880 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.414196e-01 | 0.617 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 2.289590e-01 | 0.640 |
| R-HSA-162587 | HIV Life Cycle | 3.173044e-01 | 0.499 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.024297e-01 | 0.694 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.331081e-01 | 0.632 |
| R-HSA-9758941 | Gastrulation | 2.927380e-01 | 0.534 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.796806e-01 | 0.553 |
| R-HSA-162582 | Signal Transduction | 2.782534e-01 | 0.556 |
| R-HSA-211000 | Gene Silencing by RNA | 1.527901e-01 | 0.816 |
| R-HSA-9824446 | Viral Infection Pathways | 3.183356e-01 | 0.497 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.497446e-01 | 0.603 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.370779e-01 | 0.863 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.193333e-01 | 0.496 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.029041e-01 | 0.693 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.404793e-01 | 0.619 |
| R-HSA-2028269 | Signaling by Hippo | 2.202792e-01 | 0.657 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.290543e-01 | 0.640 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.019393e-01 | 0.520 |
| R-HSA-9679506 | SARS-CoV Infections | 1.195583e-01 | 0.922 |
| R-HSA-373752 | Netrin-1 signaling | 1.176550e-01 | 0.929 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.714786e-01 | 0.566 |
| R-HSA-9675108 | Nervous system development | 1.472466e-01 | 0.832 |
| R-HSA-422475 | Axon guidance | 1.929857e-01 | 0.714 |
| R-HSA-438064 | Post NMDA receptor activation events | 9.603899e-02 | 1.018 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.115804e-01 | 0.506 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.561994e-01 | 0.591 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.914141e-01 | 0.535 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.172494e-01 | 0.663 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.163053e-01 | 0.500 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.204367e-01 | 0.494 |
| R-HSA-2029481 | FCGR activation | 3.245622e-01 | 0.489 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.245622e-01 | 0.489 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.265322e-01 | 0.486 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.269994e-01 | 0.485 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.269994e-01 | 0.485 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.269994e-01 | 0.485 |
| R-HSA-109581 | Apoptosis | 3.326844e-01 | 0.478 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.345796e-01 | 0.476 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.345796e-01 | 0.476 |
| R-HSA-2168880 | Scavenging of heme from plasma | 3.368991e-01 | 0.473 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.409969e-01 | 0.467 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.409969e-01 | 0.467 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.420749e-01 | 0.466 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.450870e-01 | 0.462 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.491689e-01 | 0.457 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.491689e-01 | 0.457 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.491689e-01 | 0.457 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.494862e-01 | 0.457 |
| R-HSA-3214847 | HATs acetylate histones | 3.532423e-01 | 0.452 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.532423e-01 | 0.452 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.568145e-01 | 0.448 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.568145e-01 | 0.448 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.568145e-01 | 0.448 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.568145e-01 | 0.448 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.640607e-01 | 0.439 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.640607e-01 | 0.439 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.640607e-01 | 0.439 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.640607e-01 | 0.439 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.640607e-01 | 0.439 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.640607e-01 | 0.439 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.640607e-01 | 0.439 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.712257e-01 | 0.430 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.712257e-01 | 0.430 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.712257e-01 | 0.430 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.712257e-01 | 0.430 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.712257e-01 | 0.430 |
| R-HSA-5205647 | Mitophagy | 3.712257e-01 | 0.430 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.712257e-01 | 0.430 |
| R-HSA-392518 | Signal amplification | 3.712257e-01 | 0.430 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.712257e-01 | 0.430 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.725681e-01 | 0.429 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.734711e-01 | 0.428 |
| R-HSA-5688426 | Deubiquitination | 3.771791e-01 | 0.423 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.783104e-01 | 0.422 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.783104e-01 | 0.422 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.783104e-01 | 0.422 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.783104e-01 | 0.422 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.814925e-01 | 0.419 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.830649e-01 | 0.417 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.853157e-01 | 0.414 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.853157e-01 | 0.414 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.853157e-01 | 0.414 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.853157e-01 | 0.414 |
| R-HSA-166786 | Creation of C4 and C2 activators | 3.854871e-01 | 0.414 |
| R-HSA-168255 | Influenza Infection | 3.878066e-01 | 0.411 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.922425e-01 | 0.406 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.922425e-01 | 0.406 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.934427e-01 | 0.405 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.974031e-01 | 0.401 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.990917e-01 | 0.399 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.990917e-01 | 0.399 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.990917e-01 | 0.399 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.013518e-01 | 0.396 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.013518e-01 | 0.396 |
| R-HSA-69541 | Stabilization of p53 | 4.058641e-01 | 0.392 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.058641e-01 | 0.392 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.058641e-01 | 0.392 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.092125e-01 | 0.388 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.131242e-01 | 0.384 |
| R-HSA-212436 | Generic Transcription Pathway | 4.158501e-01 | 0.381 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.170231e-01 | 0.380 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.170231e-01 | 0.380 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.191820e-01 | 0.378 |
| R-HSA-9694548 | Maturation of spike protein | 4.191820e-01 | 0.378 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.191820e-01 | 0.378 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.191820e-01 | 0.378 |
| R-HSA-166663 | Initial triggering of complement | 4.209091e-01 | 0.376 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.247819e-01 | 0.372 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.286413e-01 | 0.368 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.286413e-01 | 0.368 |
| R-HSA-1280218 | Adaptive Immune System | 4.310311e-01 | 0.365 |
| R-HSA-111996 | Ca-dependent events | 4.322030e-01 | 0.364 |
| R-HSA-8854214 | TBC/RABGAPs | 4.386042e-01 | 0.358 |
| R-HSA-5693538 | Homology Directed Repair | 4.401377e-01 | 0.356 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.439419e-01 | 0.353 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.439419e-01 | 0.353 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.439419e-01 | 0.353 |
| R-HSA-69236 | G1 Phase | 4.449336e-01 | 0.352 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.449336e-01 | 0.352 |
| R-HSA-449147 | Signaling by Interleukins | 4.469807e-01 | 0.350 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.511921e-01 | 0.346 |
| R-HSA-774815 | Nucleosome assembly | 4.511921e-01 | 0.346 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.515073e-01 | 0.345 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.552683e-01 | 0.342 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.552683e-01 | 0.342 |
| R-HSA-9675135 | Diseases of DNA repair | 4.573804e-01 | 0.340 |
| R-HSA-75153 | Apoptotic execution phase | 4.573804e-01 | 0.340 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.594226e-01 | 0.338 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.634992e-01 | 0.334 |
| R-HSA-977606 | Regulation of Complement cascade | 4.664623e-01 | 0.331 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.684349e-01 | 0.329 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.695495e-01 | 0.328 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.695495e-01 | 0.328 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.695495e-01 | 0.328 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.695495e-01 | 0.328 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.738495e-01 | 0.324 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.755319e-01 | 0.323 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.755319e-01 | 0.323 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.755319e-01 | 0.323 |
| R-HSA-1483257 | Phospholipid metabolism | 4.774838e-01 | 0.321 |
| R-HSA-913531 | Interferon Signaling | 4.817494e-01 | 0.317 |
| R-HSA-912446 | Meiotic recombination | 4.872961e-01 | 0.312 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.882365e-01 | 0.311 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.910778e-01 | 0.309 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.930795e-01 | 0.307 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.930795e-01 | 0.307 |
| R-HSA-9843745 | Adipogenesis | 4.956381e-01 | 0.305 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.987979e-01 | 0.302 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.987979e-01 | 0.302 |
| R-HSA-9753281 | Paracetamol ADME | 5.100430e-01 | 0.292 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.155712e-01 | 0.288 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.203271e-01 | 0.284 |
| R-HSA-1483166 | Synthesis of PA | 5.210372e-01 | 0.283 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.264420e-01 | 0.279 |
| R-HSA-6807070 | PTEN Regulation | 5.272326e-01 | 0.278 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.272326e-01 | 0.278 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.272897e-01 | 0.278 |
| R-HSA-162906 | HIV Infection | 5.300168e-01 | 0.276 |
| R-HSA-186712 | Regulation of beta-cell development | 5.317861e-01 | 0.274 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.370702e-01 | 0.270 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.370702e-01 | 0.270 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.370702e-01 | 0.270 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.370702e-01 | 0.270 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.370702e-01 | 0.270 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.408420e-01 | 0.267 |
| R-HSA-112043 | PLC beta mediated events | 5.422949e-01 | 0.266 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.422949e-01 | 0.266 |
| R-HSA-450294 | MAP kinase activation | 5.422949e-01 | 0.266 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.439719e-01 | 0.264 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.475451e-01 | 0.262 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.488598e-01 | 0.261 |
| R-HSA-166658 | Complement cascade | 5.508710e-01 | 0.259 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.525692e-01 | 0.258 |
| R-HSA-69242 | S Phase | 5.607461e-01 | 0.251 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.607461e-01 | 0.251 |
| R-HSA-157118 | Signaling by NOTCH | 5.646570e-01 | 0.248 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 5.672435e-01 | 0.246 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.672435e-01 | 0.246 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.675521e-01 | 0.246 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.704663e-01 | 0.244 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.724347e-01 | 0.242 |
| R-HSA-112040 | G-protein mediated events | 5.724347e-01 | 0.242 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.768600e-01 | 0.239 |
| R-HSA-5218859 | Regulated Necrosis | 5.772625e-01 | 0.239 |
| R-HSA-73887 | Death Receptor Signaling | 5.800308e-01 | 0.237 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.831843e-01 | 0.234 |
| R-HSA-1989781 | PPARA activates gene expression | 5.831843e-01 | 0.234 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.867559e-01 | 0.232 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.867559e-01 | 0.232 |
| R-HSA-448424 | Interleukin-17 signaling | 5.867559e-01 | 0.232 |
| R-HSA-4839726 | Chromatin organization | 5.877161e-01 | 0.231 |
| R-HSA-9610379 | HCMV Late Events | 5.894393e-01 | 0.230 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.894393e-01 | 0.230 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.914228e-01 | 0.228 |
| R-HSA-8978934 | Metabolism of cofactors | 5.914228e-01 | 0.228 |
| R-HSA-9711097 | Cellular response to starvation | 5.925407e-01 | 0.227 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.925407e-01 | 0.227 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.960373e-01 | 0.225 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.960373e-01 | 0.225 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.986914e-01 | 0.223 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.051114e-01 | 0.218 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.051114e-01 | 0.218 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 6.051114e-01 | 0.218 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.095721e-01 | 0.215 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.095721e-01 | 0.215 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.139827e-01 | 0.212 |
| R-HSA-5619102 | SLC transporter disorders | 6.196715e-01 | 0.208 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.226558e-01 | 0.206 |
| R-HSA-73894 | DNA Repair | 6.247064e-01 | 0.204 |
| R-HSA-597592 | Post-translational protein modification | 6.301683e-01 | 0.201 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.311351e-01 | 0.200 |
| R-HSA-72306 | tRNA processing | 6.312786e-01 | 0.200 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.337807e-01 | 0.198 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.353034e-01 | 0.197 |
| R-HSA-977225 | Amyloid fiber formation | 6.353034e-01 | 0.197 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.353034e-01 | 0.197 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.398027e-01 | 0.194 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.398027e-01 | 0.194 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.398027e-01 | 0.194 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.398027e-01 | 0.194 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.435000e-01 | 0.191 |
| R-HSA-1266738 | Developmental Biology | 6.442383e-01 | 0.191 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.475294e-01 | 0.189 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.475294e-01 | 0.189 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.515134e-01 | 0.186 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.587786e-01 | 0.181 |
| R-HSA-2559583 | Cellular Senescence | 6.590920e-01 | 0.181 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.593476e-01 | 0.181 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.631903e-01 | 0.178 |
| R-HSA-9658195 | Leishmania infection | 6.631903e-01 | 0.178 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.707717e-01 | 0.173 |
| R-HSA-73884 | Base Excision Repair | 6.744944e-01 | 0.171 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.781753e-01 | 0.169 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.781753e-01 | 0.169 |
| R-HSA-983712 | Ion channel transport | 6.826733e-01 | 0.166 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.877301e-01 | 0.163 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.929210e-01 | 0.159 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.000842e-01 | 0.155 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.028076e-01 | 0.153 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.061700e-01 | 0.151 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.094945e-01 | 0.149 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.160317e-01 | 0.145 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.167001e-01 | 0.145 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.192452e-01 | 0.143 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.192452e-01 | 0.143 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.255642e-01 | 0.139 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.286705e-01 | 0.137 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.286705e-01 | 0.137 |
| R-HSA-111885 | Opioid Signalling | 7.286705e-01 | 0.137 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.317417e-01 | 0.136 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.317417e-01 | 0.136 |
| R-HSA-9833110 | RSV-host interactions | 7.317417e-01 | 0.136 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.347784e-01 | 0.134 |
| R-HSA-418346 | Platelet homeostasis | 7.377809e-01 | 0.132 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.436849e-01 | 0.129 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.464040e-01 | 0.127 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.465871e-01 | 0.127 |
| R-HSA-418990 | Adherens junctions interactions | 7.518011e-01 | 0.124 |
| R-HSA-9748784 | Drug ADME | 7.518011e-01 | 0.124 |
| R-HSA-6803157 | Antimicrobial peptides | 7.522939e-01 | 0.124 |
| R-HSA-8953854 | Metabolism of RNA | 7.562659e-01 | 0.121 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.578728e-01 | 0.120 |
| R-HSA-8951664 | Neddylation | 7.579524e-01 | 0.120 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.660078e-01 | 0.116 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.686585e-01 | 0.114 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.737186e-01 | 0.111 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.738708e-01 | 0.111 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.738708e-01 | 0.111 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.764330e-01 | 0.110 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.783059e-01 | 0.109 |
| R-HSA-73886 | Chromosome Maintenance | 7.839476e-01 | 0.106 |
| R-HSA-15869 | Metabolism of nucleotides | 7.867755e-01 | 0.104 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.885704e-01 | 0.103 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.885860e-01 | 0.103 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.888173e-01 | 0.103 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.912110e-01 | 0.102 |
| R-HSA-194138 | Signaling by VEGF | 7.959178e-01 | 0.099 |
| R-HSA-69481 | G2/M Checkpoints | 8.005190e-01 | 0.097 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.027808e-01 | 0.095 |
| R-HSA-112316 | Neuronal System | 8.056651e-01 | 0.094 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.059623e-01 | 0.094 |
| R-HSA-109582 | Hemostasis | 8.089997e-01 | 0.092 |
| R-HSA-9717189 | Sensory perception of taste | 8.115758e-01 | 0.091 |
| R-HSA-5576891 | Cardiac conduction | 8.115758e-01 | 0.091 |
| R-HSA-421270 | Cell-cell junction organization | 8.125518e-01 | 0.090 |
| R-HSA-9909396 | Circadian clock | 8.137129e-01 | 0.090 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.205090e-01 | 0.086 |
| R-HSA-5663205 | Infectious disease | 8.217535e-01 | 0.085 |
| R-HSA-5368287 | Mitochondrial translation | 8.280125e-01 | 0.082 |
| R-HSA-168256 | Immune System | 8.394698e-01 | 0.076 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.448047e-01 | 0.073 |
| R-HSA-166520 | Signaling by NTRKs | 8.483090e-01 | 0.071 |
| R-HSA-446728 | Cell junction organization | 8.520481e-01 | 0.070 |
| R-HSA-2142753 | Arachidonate metabolism | 8.550831e-01 | 0.068 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.833711e-01 | 0.054 |
| R-HSA-382551 | Transport of small molecules | 8.844094e-01 | 0.053 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.860087e-01 | 0.053 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.873051e-01 | 0.052 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.898541e-01 | 0.051 |
| R-HSA-611105 | Respiratory electron transport | 8.935706e-01 | 0.049 |
| R-HSA-1500931 | Cell-Cell communication | 8.949058e-01 | 0.048 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.994895e-01 | 0.046 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.050810e-01 | 0.043 |
| R-HSA-6798695 | Neutrophil degranulation | 9.087391e-01 | 0.042 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.103630e-01 | 0.041 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.113838e-01 | 0.040 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.165039e-01 | 0.038 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.172703e-01 | 0.038 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.200660e-01 | 0.036 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.210318e-01 | 0.036 |
| R-HSA-72172 | mRNA Splicing | 9.218774e-01 | 0.035 |
| R-HSA-6805567 | Keratinization | 9.236480e-01 | 0.034 |
| R-HSA-397014 | Muscle contraction | 9.287238e-01 | 0.032 |
| R-HSA-1643685 | Disease | 9.378036e-01 | 0.028 |
| R-HSA-72312 | rRNA processing | 9.433400e-01 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.512112e-01 | 0.022 |
| R-HSA-392499 | Metabolism of proteins | 9.553245e-01 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 9.556727e-01 | 0.020 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.650406e-01 | 0.015 |
| R-HSA-168249 | Innate Immune System | 9.724354e-01 | 0.012 |
| R-HSA-195721 | Signaling by WNT | 9.734858e-01 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 9.818840e-01 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.876320e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.925743e-01 | 0.003 |
| R-HSA-72766 | Translation | 9.942493e-01 | 0.003 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.943451e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.945361e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.975469e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.986355e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999996e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.775 | 0.451 | -3 | 0.655 |
CK1D |
0.774 | 0.463 | -3 | 0.667 |
CK1A2 |
0.770 | 0.458 | -3 | 0.669 |
GRK1 |
0.770 | 0.378 | -2 | 0.865 |
CK1A |
0.765 | 0.443 | -3 | 0.673 |
CK1G1 |
0.761 | 0.417 | -3 | 0.631 |
GSK3B |
0.759 | 0.434 | 4 | 0.741 |
GSK3A |
0.758 | 0.414 | 4 | 0.740 |
COT |
0.752 | 0.182 | 2 | 0.843 |
KIS |
0.751 | 0.136 | 1 | 0.618 |
CDC7 |
0.741 | 0.121 | 1 | 0.807 |
GRK6 |
0.741 | 0.331 | 1 | 0.789 |
MOS |
0.741 | 0.161 | 1 | 0.814 |
GRK7 |
0.740 | 0.260 | 1 | 0.714 |
CLK3 |
0.738 | 0.124 | 1 | 0.746 |
GRK5 |
0.738 | 0.289 | -3 | 0.367 |
IKKB |
0.737 | 0.111 | -2 | 0.729 |
GRK4 |
0.737 | 0.268 | -2 | 0.851 |
CK1G3 |
0.737 | 0.408 | -3 | 0.670 |
PIM3 |
0.735 | 0.059 | -3 | 0.256 |
MTOR |
0.734 | 0.063 | 1 | 0.709 |
CK1G2 |
0.731 | 0.381 | -3 | 0.654 |
BMPR1B |
0.731 | 0.166 | 1 | 0.783 |
GRK3 |
0.730 | 0.228 | -2 | 0.716 |
IKKA |
0.729 | 0.089 | -2 | 0.729 |
CLK2 |
0.728 | 0.117 | -3 | 0.221 |
CAMK2G |
0.728 | 0.101 | 2 | 0.754 |
NDR2 |
0.727 | 0.022 | -3 | 0.252 |
DSTYK |
0.726 | 0.026 | 2 | 0.835 |
PRPK |
0.726 | -0.012 | -1 | 0.790 |
ATR |
0.725 | 0.037 | 1 | 0.782 |
CAMK2B |
0.724 | 0.119 | 2 | 0.726 |
MLK1 |
0.723 | 0.092 | 2 | 0.783 |
PIM1 |
0.723 | 0.046 | -3 | 0.257 |
RSK2 |
0.722 | 0.026 | -3 | 0.198 |
GRK2 |
0.722 | 0.161 | -2 | 0.738 |
SRPK1 |
0.722 | 0.013 | -3 | 0.212 |
FAM20C |
0.722 | 0.072 | 2 | 0.520 |
RAF1 |
0.721 | -0.023 | 1 | 0.763 |
CDKL1 |
0.720 | -0.029 | -3 | 0.227 |
PDHK4 |
0.719 | -0.062 | 1 | 0.774 |
CAMK2A |
0.719 | 0.103 | 2 | 0.748 |
GCN2 |
0.719 | -0.083 | 2 | 0.755 |
SKMLCK |
0.718 | 0.032 | -2 | 0.791 |
BMPR2 |
0.718 | -0.021 | -2 | 0.842 |
MAPKAPK2 |
0.717 | -0.003 | -3 | 0.190 |
CAMK1B |
0.717 | -0.038 | -3 | 0.254 |
NLK |
0.717 | -0.026 | 1 | 0.751 |
ATM |
0.717 | 0.048 | 1 | 0.739 |
DLK |
0.717 | 0.144 | 1 | 0.774 |
BMPR1A |
0.717 | 0.140 | 1 | 0.772 |
P90RSK |
0.716 | 0.003 | -3 | 0.198 |
CHAK2 |
0.716 | 0.027 | -1 | 0.733 |
SRPK3 |
0.716 | 0.008 | -3 | 0.222 |
ACVR2B |
0.716 | 0.119 | -2 | 0.778 |
TBK1 |
0.716 | -0.044 | 1 | 0.651 |
IKKE |
0.716 | -0.028 | 1 | 0.649 |
RIPK3 |
0.716 | 0.018 | 3 | 0.708 |
ERK5 |
0.715 | -0.014 | 1 | 0.715 |
CK2A1 |
0.715 | 0.204 | 1 | 0.666 |
SRPK2 |
0.714 | -0.010 | -3 | 0.188 |
HIPK4 |
0.714 | -0.013 | 1 | 0.743 |
TGFBR1 |
0.714 | 0.073 | -2 | 0.798 |
ACVR2A |
0.714 | 0.113 | -2 | 0.767 |
MST4 |
0.712 | -0.010 | 2 | 0.829 |
ALK2 |
0.711 | 0.109 | -2 | 0.812 |
ALK4 |
0.711 | 0.076 | -2 | 0.818 |
RSK4 |
0.711 | 0.027 | -3 | 0.205 |
CAMK2D |
0.711 | 0.018 | -3 | 0.223 |
NUAK2 |
0.711 | -0.052 | -3 | 0.255 |
CDKL5 |
0.711 | -0.042 | -3 | 0.214 |
CK2A2 |
0.711 | 0.148 | 1 | 0.686 |
BCKDK |
0.711 | -0.065 | -1 | 0.764 |
CLK4 |
0.711 | 0.029 | -3 | 0.234 |
PRKX |
0.710 | 0.029 | -3 | 0.205 |
PRKD1 |
0.710 | -0.050 | -3 | 0.199 |
PASK |
0.709 | 0.144 | -3 | 0.274 |
DYRK2 |
0.709 | 0.017 | 1 | 0.673 |
NEK7 |
0.708 | -0.084 | -3 | 0.265 |
TGFBR2 |
0.708 | -0.055 | -2 | 0.768 |
PDHK1 |
0.708 | -0.159 | 1 | 0.763 |
TTBK2 |
0.708 | 0.017 | 2 | 0.654 |
MSK1 |
0.708 | 0.027 | -3 | 0.207 |
PKN3 |
0.708 | -0.068 | -3 | 0.228 |
DAPK2 |
0.708 | -0.051 | -3 | 0.248 |
NIK |
0.707 | -0.079 | -3 | 0.266 |
NDR1 |
0.707 | -0.064 | -3 | 0.240 |
CDK8 |
0.707 | -0.007 | 1 | 0.620 |
MEKK3 |
0.707 | 0.193 | 1 | 0.730 |
HUNK |
0.707 | -0.072 | 2 | 0.770 |
CDK1 |
0.707 | 0.032 | 1 | 0.580 |
ULK2 |
0.707 | -0.145 | 2 | 0.747 |
ICK |
0.706 | -0.022 | -3 | 0.236 |
LATS1 |
0.706 | 0.058 | -3 | 0.231 |
MLK4 |
0.706 | 0.058 | 2 | 0.703 |
MAPKAPK3 |
0.706 | -0.067 | -3 | 0.194 |
MASTL |
0.706 | -0.051 | -2 | 0.777 |
P70S6KB |
0.706 | -0.037 | -3 | 0.221 |
PKN2 |
0.706 | -0.062 | -3 | 0.258 |
PKACG |
0.706 | -0.013 | -2 | 0.636 |
PRKD2 |
0.706 | -0.058 | -3 | 0.186 |
LATS2 |
0.705 | -0.033 | -5 | 0.733 |
MSK2 |
0.705 | -0.021 | -3 | 0.216 |
MARK4 |
0.705 | -0.090 | 4 | 0.330 |
CAMLCK |
0.705 | -0.050 | -2 | 0.769 |
CDK19 |
0.705 | -0.003 | 1 | 0.587 |
PLK1 |
0.704 | 0.053 | -2 | 0.734 |
RSK3 |
0.704 | -0.057 | -3 | 0.183 |
NEK6 |
0.703 | -0.112 | -2 | 0.794 |
SMG1 |
0.703 | 0.008 | 1 | 0.745 |
JNK3 |
0.703 | 0.038 | 1 | 0.588 |
ULK1 |
0.703 | -0.098 | -3 | 0.244 |
MEK1 |
0.703 | 0.079 | 2 | 0.822 |
MLK3 |
0.703 | -0.017 | 2 | 0.725 |
RIPK1 |
0.703 | -0.034 | 1 | 0.748 |
PKACB |
0.703 | -0.003 | -2 | 0.557 |
HIPK2 |
0.702 | 0.014 | 1 | 0.586 |
AMPKA1 |
0.702 | -0.088 | -3 | 0.251 |
CLK1 |
0.702 | 0.000 | -3 | 0.200 |
ANKRD3 |
0.702 | -0.043 | 1 | 0.781 |
TLK2 |
0.701 | 0.044 | 1 | 0.737 |
WNK1 |
0.701 | -0.081 | -2 | 0.815 |
DNAPK |
0.700 | 0.046 | 1 | 0.658 |
YSK4 |
0.699 | -0.004 | 1 | 0.698 |
DYRK4 |
0.699 | 0.034 | 1 | 0.592 |
MLK2 |
0.698 | -0.092 | 2 | 0.797 |
IRE1 |
0.698 | -0.063 | 1 | 0.729 |
JNK2 |
0.698 | 0.026 | 1 | 0.555 |
NEK9 |
0.698 | -0.113 | 2 | 0.791 |
PKCD |
0.697 | -0.068 | 2 | 0.772 |
AMPKA2 |
0.697 | -0.085 | -3 | 0.234 |
HIPK1 |
0.697 | -0.001 | 1 | 0.685 |
GAK |
0.696 | 0.172 | 1 | 0.793 |
MYLK4 |
0.696 | -0.022 | -2 | 0.685 |
PLK3 |
0.696 | 0.018 | 2 | 0.716 |
AURC |
0.696 | -0.026 | -2 | 0.556 |
VRK2 |
0.696 | -0.030 | 1 | 0.815 |
CAMK4 |
0.696 | -0.084 | -3 | 0.252 |
CDK18 |
0.696 | -0.007 | 1 | 0.551 |
PKR |
0.695 | -0.029 | 1 | 0.771 |
PLK2 |
0.695 | 0.066 | -3 | 0.254 |
ERK1 |
0.694 | 0.011 | 1 | 0.556 |
QSK |
0.694 | -0.080 | 4 | 0.299 |
P38B |
0.694 | 0.017 | 1 | 0.566 |
AKT2 |
0.694 | -0.042 | -3 | 0.191 |
PRP4 |
0.694 | -0.034 | -3 | 0.217 |
PAK1 |
0.694 | -0.045 | -2 | 0.700 |
CDK13 |
0.693 | -0.007 | 1 | 0.584 |
NIM1 |
0.693 | -0.086 | 3 | 0.736 |
WNK3 |
0.693 | -0.191 | 1 | 0.736 |
PIM2 |
0.693 | -0.037 | -3 | 0.201 |
SIK |
0.692 | -0.088 | -3 | 0.218 |
DRAK1 |
0.692 | -0.001 | 1 | 0.703 |
P38D |
0.692 | 0.031 | 1 | 0.523 |
YANK3 |
0.692 | 0.124 | 2 | 0.392 |
MST3 |
0.692 | 0.053 | 2 | 0.810 |
PKCB |
0.692 | -0.058 | 2 | 0.720 |
P38G |
0.691 | 0.008 | 1 | 0.500 |
TSSK2 |
0.691 | -0.088 | -5 | 0.802 |
AURA |
0.690 | -0.008 | -2 | 0.541 |
MAPKAPK5 |
0.690 | -0.075 | -3 | 0.183 |
P38A |
0.690 | -0.012 | 1 | 0.627 |
JNK1 |
0.690 | 0.041 | 1 | 0.552 |
MARK3 |
0.690 | -0.080 | 4 | 0.301 |
MEKK2 |
0.690 | 0.058 | 2 | 0.772 |
TLK1 |
0.690 | 0.023 | -2 | 0.813 |
CAMK1G |
0.689 | -0.057 | -3 | 0.216 |
MARK2 |
0.689 | -0.098 | 4 | 0.278 |
QIK |
0.689 | -0.130 | -3 | 0.240 |
CHAK1 |
0.689 | -0.083 | 2 | 0.740 |
TSSK1 |
0.689 | -0.107 | -3 | 0.244 |
ERK2 |
0.689 | -0.006 | 1 | 0.594 |
CDK7 |
0.689 | -0.045 | 1 | 0.612 |
CDK5 |
0.688 | -0.024 | 1 | 0.630 |
PKCA |
0.688 | -0.070 | 2 | 0.714 |
CDK17 |
0.688 | -0.012 | 1 | 0.502 |
ZAK |
0.688 | -0.016 | 1 | 0.734 |
PKCG |
0.688 | -0.075 | 2 | 0.720 |
DYRK1A |
0.687 | -0.037 | 1 | 0.659 |
MPSK1 |
0.687 | 0.005 | 1 | 0.729 |
BRSK1 |
0.687 | -0.101 | -3 | 0.212 |
PRKD3 |
0.687 | -0.099 | -3 | 0.185 |
PAK2 |
0.686 | -0.061 | -2 | 0.687 |
TAO3 |
0.686 | -0.000 | 1 | 0.709 |
DYRK3 |
0.686 | -0.017 | 1 | 0.698 |
MEK5 |
0.686 | -0.042 | 2 | 0.795 |
PKACA |
0.686 | -0.028 | -2 | 0.507 |
PAK3 |
0.686 | -0.091 | -2 | 0.692 |
DAPK1 |
0.686 | 0.019 | -3 | 0.248 |
PKG2 |
0.686 | -0.054 | -2 | 0.558 |
NUAK1 |
0.685 | -0.129 | -3 | 0.212 |
AURB |
0.685 | -0.041 | -2 | 0.551 |
PKCH |
0.684 | -0.079 | 2 | 0.696 |
CDK2 |
0.684 | -0.042 | 1 | 0.658 |
SGK3 |
0.684 | -0.070 | -3 | 0.204 |
CDK14 |
0.684 | -0.019 | 1 | 0.590 |
BRAF |
0.684 | -0.069 | -4 | 0.819 |
CDK12 |
0.683 | -0.019 | 1 | 0.556 |
CDK10 |
0.683 | 0.003 | 1 | 0.576 |
IRE2 |
0.683 | -0.103 | 2 | 0.712 |
PERK |
0.683 | -0.072 | -2 | 0.816 |
PHKG1 |
0.683 | -0.122 | -3 | 0.245 |
MELK |
0.683 | -0.135 | -3 | 0.212 |
MEKK1 |
0.683 | -0.076 | 1 | 0.744 |
P70S6K |
0.682 | -0.053 | -3 | 0.180 |
PKCZ |
0.682 | -0.092 | 2 | 0.748 |
TTBK1 |
0.682 | -0.027 | 2 | 0.578 |
MNK1 |
0.681 | -0.073 | -2 | 0.686 |
DAPK3 |
0.681 | -0.024 | -3 | 0.241 |
MARK1 |
0.681 | -0.112 | 4 | 0.298 |
DYRK1B |
0.681 | -0.022 | 1 | 0.603 |
CDK16 |
0.681 | -0.017 | 1 | 0.520 |
DCAMKL1 |
0.681 | -0.074 | -3 | 0.214 |
PINK1 |
0.680 | -0.140 | 1 | 0.748 |
HIPK3 |
0.680 | -0.051 | 1 | 0.653 |
BRSK2 |
0.680 | -0.138 | -3 | 0.219 |
CDK3 |
0.680 | -0.012 | 1 | 0.523 |
GCK |
0.679 | 0.020 | 1 | 0.708 |
CDK9 |
0.679 | -0.043 | 1 | 0.592 |
NEK11 |
0.679 | -0.035 | 1 | 0.697 |
TAK1 |
0.679 | 0.069 | 1 | 0.738 |
MST2 |
0.678 | 0.005 | 1 | 0.726 |
NEK2 |
0.678 | -0.155 | 2 | 0.772 |
EEF2K |
0.678 | 0.034 | 3 | 0.792 |
SMMLCK |
0.678 | -0.062 | -3 | 0.229 |
SGK1 |
0.678 | -0.030 | -3 | 0.166 |
CAMK1D |
0.677 | -0.067 | -3 | 0.178 |
PAK6 |
0.677 | -0.077 | -2 | 0.615 |
CHK1 |
0.677 | -0.129 | -3 | 0.194 |
AKT1 |
0.677 | -0.063 | -3 | 0.193 |
NEK5 |
0.676 | -0.121 | 1 | 0.752 |
MNK2 |
0.676 | -0.111 | -2 | 0.675 |
HRI |
0.675 | -0.149 | -2 | 0.801 |
SNRK |
0.674 | -0.173 | 2 | 0.650 |
MAK |
0.672 | -0.006 | -2 | 0.706 |
PLK4 |
0.672 | -0.104 | 2 | 0.601 |
ALPHAK3 |
0.672 | 0.137 | -1 | 0.694 |
CAMKK1 |
0.671 | -0.099 | -2 | 0.716 |
HPK1 |
0.671 | 0.003 | 1 | 0.688 |
CHK2 |
0.670 | -0.079 | -3 | 0.164 |
PKCE |
0.670 | -0.054 | 2 | 0.700 |
DCAMKL2 |
0.669 | -0.100 | -3 | 0.213 |
NEK8 |
0.669 | -0.097 | 2 | 0.776 |
MINK |
0.669 | -0.028 | 1 | 0.704 |
SSTK |
0.669 | -0.105 | 4 | 0.284 |
YANK2 |
0.669 | 0.132 | 2 | 0.406 |
WNK4 |
0.668 | -0.140 | -2 | 0.806 |
TAO2 |
0.668 | -0.105 | 2 | 0.810 |
IRAK4 |
0.668 | -0.141 | 1 | 0.737 |
PDHK4_TYR |
0.668 | 0.224 | 2 | 0.844 |
ERK7 |
0.668 | -0.029 | 2 | 0.519 |
AKT3 |
0.667 | -0.061 | -3 | 0.168 |
PDK1 |
0.667 | -0.083 | 1 | 0.695 |
PKCT |
0.666 | -0.113 | 2 | 0.709 |
CAMKK2 |
0.666 | -0.089 | -2 | 0.705 |
LKB1 |
0.666 | -0.122 | -3 | 0.240 |
BMPR2_TYR |
0.666 | 0.157 | -1 | 0.836 |
MAP2K6_TYR |
0.666 | 0.239 | -1 | 0.816 |
SBK |
0.666 | -0.049 | -3 | 0.136 |
VRK1 |
0.665 | -0.066 | 2 | 0.799 |
MAP3K15 |
0.665 | -0.081 | 1 | 0.701 |
PDHK3_TYR |
0.665 | 0.153 | 4 | 0.411 |
PHKG2 |
0.665 | -0.142 | -3 | 0.221 |
MST1 |
0.665 | -0.044 | 1 | 0.703 |
MOK |
0.665 | -0.034 | 1 | 0.703 |
TNIK |
0.663 | -0.064 | 3 | 0.829 |
IRAK1 |
0.663 | -0.172 | -1 | 0.678 |
PKCI |
0.663 | -0.095 | 2 | 0.720 |
KHS2 |
0.663 | -0.007 | 1 | 0.696 |
HGK |
0.663 | -0.075 | 3 | 0.826 |
MRCKA |
0.662 | -0.049 | -3 | 0.209 |
TTK |
0.662 | 0.027 | -2 | 0.775 |
PDHK1_TYR |
0.661 | 0.148 | -1 | 0.826 |
OSR1 |
0.661 | 0.004 | 2 | 0.795 |
LRRK2 |
0.661 | -0.110 | 2 | 0.795 |
STK33 |
0.661 | -0.045 | 2 | 0.597 |
MEKK6 |
0.661 | -0.146 | 1 | 0.728 |
CAMK1A |
0.661 | -0.086 | -3 | 0.167 |
PAK5 |
0.660 | -0.086 | -2 | 0.554 |
SLK |
0.660 | -0.061 | -2 | 0.658 |
ROCK2 |
0.659 | -0.060 | -3 | 0.228 |
CDK6 |
0.659 | -0.043 | 1 | 0.568 |
MAP2K4_TYR |
0.659 | 0.093 | -1 | 0.807 |
PAK4 |
0.658 | -0.063 | -2 | 0.563 |
DMPK1 |
0.658 | -0.038 | -3 | 0.218 |
KHS1 |
0.658 | -0.054 | 1 | 0.687 |
SYK |
0.658 | 0.203 | -1 | 0.772 |
MRCKB |
0.657 | -0.078 | -3 | 0.204 |
NEK4 |
0.657 | -0.166 | 1 | 0.706 |
PBK |
0.655 | -0.045 | 1 | 0.716 |
NEK1 |
0.653 | -0.175 | 1 | 0.722 |
PKN1 |
0.653 | -0.117 | -3 | 0.184 |
BUB1 |
0.653 | -0.055 | -5 | 0.772 |
CDK4 |
0.653 | -0.051 | 1 | 0.550 |
LOK |
0.652 | -0.124 | -2 | 0.685 |
TXK |
0.652 | 0.065 | 1 | 0.799 |
RIPK2 |
0.651 | -0.149 | 1 | 0.661 |
EPHB4 |
0.651 | 0.022 | -1 | 0.786 |
CRIK |
0.650 | -0.044 | -3 | 0.181 |
HASPIN |
0.650 | -0.029 | -1 | 0.587 |
TESK1_TYR |
0.650 | -0.081 | 3 | 0.837 |
MAP2K7_TYR |
0.650 | -0.045 | 2 | 0.810 |
MEK2 |
0.650 | -0.188 | 2 | 0.783 |
YSK1 |
0.649 | -0.115 | 2 | 0.769 |
PKMYT1_TYR |
0.649 | -0.062 | 3 | 0.805 |
FGR |
0.648 | 0.034 | 1 | 0.785 |
EPHA6 |
0.648 | -0.014 | -1 | 0.815 |
PINK1_TYR |
0.648 | -0.051 | 1 | 0.761 |
PTK2 |
0.647 | 0.122 | -1 | 0.796 |
EPHA4 |
0.647 | 0.027 | 2 | 0.730 |
FYN |
0.647 | 0.089 | -1 | 0.811 |
ROCK1 |
0.646 | -0.073 | -3 | 0.213 |
BLK |
0.645 | 0.035 | -1 | 0.803 |
LCK |
0.644 | 0.015 | -1 | 0.810 |
SRMS |
0.644 | 0.022 | 1 | 0.803 |
FER |
0.644 | -0.032 | 1 | 0.818 |
ABL2 |
0.644 | -0.010 | -1 | 0.740 |
FLT1 |
0.643 | 0.094 | -1 | 0.787 |
YES1 |
0.643 | -0.015 | -1 | 0.790 |
PKG1 |
0.642 | -0.099 | -2 | 0.467 |
MET |
0.642 | 0.036 | 3 | 0.750 |
EPHB1 |
0.642 | 0.003 | 1 | 0.796 |
HCK |
0.641 | -0.020 | -1 | 0.800 |
EPHB2 |
0.641 | 0.010 | -1 | 0.772 |
ABL1 |
0.641 | -0.013 | -1 | 0.731 |
BIKE |
0.640 | -0.028 | 1 | 0.700 |
INSRR |
0.640 | 0.001 | 3 | 0.695 |
KIT |
0.640 | 0.010 | 3 | 0.754 |
ASK1 |
0.640 | -0.106 | 1 | 0.693 |
EPHB3 |
0.639 | -0.011 | -1 | 0.779 |
RET |
0.639 | -0.107 | 1 | 0.735 |
CSF1R |
0.638 | -0.057 | 3 | 0.751 |
MYO3B |
0.638 | -0.112 | 2 | 0.787 |
BMX |
0.638 | 0.018 | -1 | 0.689 |
MYO3A |
0.638 | -0.095 | 1 | 0.701 |
MST1R |
0.637 | -0.125 | 3 | 0.773 |
ZAP70 |
0.637 | 0.142 | -1 | 0.694 |
STLK3 |
0.637 | -0.074 | 1 | 0.683 |
ITK |
0.637 | -0.039 | -1 | 0.762 |
DDR1 |
0.636 | -0.099 | 4 | 0.353 |
TYK2 |
0.636 | -0.143 | 1 | 0.730 |
JAK3 |
0.636 | -0.052 | 1 | 0.723 |
ERBB2 |
0.635 | 0.010 | 1 | 0.714 |
EPHA5 |
0.635 | 0.037 | 2 | 0.714 |
JAK2 |
0.635 | -0.118 | 1 | 0.728 |
KDR |
0.635 | -0.022 | 3 | 0.720 |
TYRO3 |
0.634 | -0.138 | 3 | 0.745 |
LIMK2_TYR |
0.634 | -0.174 | -3 | 0.239 |
ROS1 |
0.634 | -0.148 | 3 | 0.716 |
ERBB4 |
0.633 | 0.089 | 1 | 0.671 |
NEK3 |
0.633 | -0.223 | 1 | 0.685 |
EPHA3 |
0.633 | -0.018 | 2 | 0.702 |
TAO1 |
0.633 | -0.129 | 1 | 0.639 |
FLT3 |
0.633 | -0.072 | 3 | 0.748 |
EPHA7 |
0.632 | -0.020 | 2 | 0.730 |
TNK2 |
0.632 | -0.064 | 3 | 0.725 |
EPHA8 |
0.631 | 0.017 | -1 | 0.782 |
SRC |
0.631 | 0.023 | -1 | 0.783 |
TEC |
0.631 | -0.047 | -1 | 0.683 |
LIMK1_TYR |
0.631 | -0.232 | 2 | 0.803 |
FGFR2 |
0.630 | -0.072 | 3 | 0.757 |
EGFR |
0.630 | 0.020 | 1 | 0.640 |
FRK |
0.630 | -0.023 | -1 | 0.791 |
MERTK |
0.629 | -0.052 | 3 | 0.737 |
LYN |
0.629 | -0.023 | 3 | 0.668 |
FGFR3 |
0.629 | -0.010 | 3 | 0.727 |
WEE1_TYR |
0.629 | -0.029 | -1 | 0.693 |
BTK |
0.629 | -0.096 | -1 | 0.725 |
NTRK1 |
0.628 | -0.059 | -1 | 0.770 |
PDGFRB |
0.627 | -0.120 | 3 | 0.760 |
PTK2B |
0.626 | -0.020 | -1 | 0.712 |
DDR2 |
0.626 | 0.000 | 3 | 0.690 |
PTK6 |
0.625 | -0.098 | -1 | 0.680 |
MATK |
0.624 | -0.019 | -1 | 0.657 |
FGFR4 |
0.624 | 0.015 | -1 | 0.704 |
NTRK3 |
0.623 | -0.052 | -1 | 0.733 |
AXL |
0.622 | -0.112 | 3 | 0.736 |
JAK1 |
0.622 | -0.108 | 1 | 0.675 |
AAK1 |
0.622 | -0.012 | 1 | 0.606 |
EPHA2 |
0.622 | 0.003 | -1 | 0.753 |
TEK |
0.621 | -0.145 | 3 | 0.678 |
FLT4 |
0.620 | -0.065 | 3 | 0.706 |
FGFR1 |
0.620 | -0.129 | 3 | 0.718 |
INSR |
0.619 | -0.088 | 3 | 0.674 |
EPHA1 |
0.619 | -0.106 | 3 | 0.738 |
TNNI3K_TYR |
0.619 | -0.114 | 1 | 0.765 |
ALK |
0.618 | -0.137 | 3 | 0.665 |
NTRK2 |
0.618 | -0.119 | 3 | 0.700 |
CSK |
0.618 | -0.029 | 2 | 0.730 |
PDGFRA |
0.618 | -0.178 | 3 | 0.754 |
NEK10_TYR |
0.617 | -0.136 | 1 | 0.591 |
LTK |
0.617 | -0.120 | 3 | 0.693 |
TNK1 |
0.612 | -0.192 | 3 | 0.732 |
IGF1R |
0.611 | -0.044 | 3 | 0.608 |
FES |
0.607 | -0.026 | -1 | 0.664 |
MUSK |
0.602 | -0.103 | 1 | 0.613 |