Motif 532 (n=117)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0C4DFX4 None S549 ochoa Snf2 related CREBBP activator protein None
O00425 IGF2BP3 S438 ochoa Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}.
O00479 HMGN4 S29 ochoa High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein) None
O15042 U2SURP S174 ochoa U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) None
O15381 NVL S149 ochoa Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}.
O43390 HNRNPR S428 ochoa Heterogeneous nuclear ribonucleoprotein R (hnRNP R) Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
O43663 PRC1 S466 ochoa Protein regulator of cytokinesis 1 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.
O43683 BUB1 S437 ochoa Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O75121 MFAP3L S307 ochoa Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}.
O75122 CLASP2 S22 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75128 COBL S440 ochoa Protein cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
O75815 BCAR3 S395 ochoa Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.
O94955 RHOBTB3 S215 ochoa Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.
O95239 KIF4A S1017 ochoa Chromosome-associated kinesin KIF4A (Chromokinesin-A) Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}.
O95684 CEP43 S207 ochoa Centrosomal protein 43 (FGFR1 oncogene partner) Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
O95997 PTTG1 S89 psp Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}.
P04049 RAF1 S322 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P05114 HMGN1 S25 ochoa|psp Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.
P05204 HMGN2 S29 ochoa|psp Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2) Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.
P09661 SNRPA1 S178 ochoa U2 small nuclear ribonucleoprotein A' (U2 snRNP A') Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}.
P0DMV8 HSPA1A S537 ochoa Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P0DMV9 HSPA1B S537 ochoa Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P11388 TOP2A S1452 ochoa DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
P12270 TPR S1662 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P14866 HNRNPL S291 ochoa Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
P18669 PGAM1 S118 ochoa|psp Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}.
P20810 CAST S87 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P27987 ITPKB S159 ochoa Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
P28370 SMARCA1 S112 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
P28715 ERCC5 S311 ochoa DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.
P30041 PRDX6 S186 ochoa Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:26830860, ECO:0000269|PubMed:9497358}.
P31645 SLC6A4 S48 psp Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}.
P33981 TTK S403 ochoa Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35249 RFC4 S29 ochoa Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble. {ECO:0000269|PubMed:39106866, ECO:0000269|PubMed:9488738}.
P35579 MYH9 S1714 ochoa Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
P38398 BRCA1 S708 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P42285 MTREX S40 ochoa Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}.
P45983 MAPK8 S179 ochoa Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:16581800, PubMed:17296730, PubMed:20027304). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572). {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28943315, ECO:0000269|PubMed:34048572}.; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
P46100 ATRX S594 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46734 MAP2K3 S31 ochoa Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.
P46779 RPL28 S37 ochoa Large ribosomal subunit protein eL28 (60S ribosomal protein L28) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
P51825 AFF1 T372 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P51825 AFF1 S872 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P53779 MAPK10 S217 ochoa Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.
P60484 PTEN S362 psp Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}.
P61964 WDR5 S20 ochoa WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
P82970 HMGN5 S24 ochoa High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}.
Q01484 ANK2 S2447 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q08050 FOXM1 S613 ochoa Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q13620 CUL4B S193 ochoa Cullin-4B (CUL-4B) Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.
Q14004 CDK13 S291 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14684 RRP1B S662 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14721 KCNB1 S730 ochoa Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:10484328, PubMed:12560340, PubMed:1283219, PubMed:19074135, PubMed:19717558, PubMed:24901643, PubMed:8081723). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}.
Q14980 NUMA1 S2051 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15014 MORF4L2 S90 ochoa Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Q15651 HMGN3 S31 ochoa High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
Q15910 EZH2 S474 ochoa Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}.
Q15942 ZYX S505 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q52LD8 RFTN2 S405 ochoa Raftlin-2 (Raft-linking protein 2) Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}.
Q5TKA1 LIN9 S207 ochoa Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}.
Q5VZL5 ZMYM4 S302 ochoa Zinc finger MYM-type protein 4 (Zinc finger protein 262) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q658Y4 FAM91A1 S310 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q6P4R8 NFRKB T340 ochoa Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.
Q6WKZ4 RAB11FIP1 S234 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZRS2 SRCAP S568 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q702N8 XIRP1 S1737 ochoa Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}.
Q765P7 MTSS2 S580 ochoa Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.
Q76L83 ASXL2 S580 ochoa Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}.
Q7KZF4 SND1 S238 ochoa Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}.
Q7Z2Z1 TICRR S1303 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z417 NUFIP2 S349 ochoa FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
Q7Z5J4 RAI1 S1226 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q86V48 LUZP1 S878 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q86YV0 RASAL3 S58 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q8N0Y7 PGAM4 S118 ochoa Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) None
Q8N488 RYBP S130 ochoa RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}.
Q8NC51 SERBP1 S85 ochoa SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}.
Q8NEM7 SUPT20H S453 ochoa Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}.
Q8WX93 PALLD S1352 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q96F63 CCDC97 S29 ochoa Coiled-coil domain-containing protein 97 May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}.
Q96GX5 MASTL S512 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96MU7 YTHDC1 S120 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96N46 TTC14 S544 ochoa Tetratricopeptide repeat protein 14 (TPR repeat protein 14) None
Q96PY5 FMNL2 S679 ochoa Formin-like protein 2 (Formin homology 2 domain-containing protein 2) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}.
Q9BR76 CORO1B S413 ochoa Coronin-1B (Coronin-2) Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.
Q9BRR8 GPATCH1 S357 ochoa G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) None
Q9BTE3 MCMBP S193 ochoa Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.
Q9BXP5 SRRT S540 ochoa Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}.
Q9H2F5 EPC1 S348 ochoa Enhancer of polycomb homolog 1 Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.
Q9H4X1 RGCC S107 ochoa Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
Q9H6S3 EPS8L2 S197 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9H7N4 SCAF1 S1136 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9HAZ2 PRDM16 S437 ochoa Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}.
Q9HBM6 TAF9B S153 ochoa Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.
Q9NQS7 INCENP S803 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NRY4 ARHGAP35 S1221 psp Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.
Q9NZI8 IGF2BP1 S438 ochoa Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}.
Q9P242 NYAP2 S183 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P289 STK26 S325 ochoa Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}.
Q9UBZ4 APEX2 S236 ochoa DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}.
Q9UHB7 AFF4 T332 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UK61 TASOR S972 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9ULW0 TPX2 S125 ochoa|psp Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UPT5 EXOC7 S245 ochoa Exocyst complex component 7 (Exocyst complex component Exo70) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}.
Q9Y5V3 MAGED1 S175 ochoa Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
Q9Y6D5 ARFGEF2 S1514 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}.
R4GMW8 BIVM-ERCC5 S765 ochoa DNA excision repair protein ERCC-5 None
P31153 MAT2A S247 Sugiyama S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}.
O60828 PQBP1 S210 Sugiyama Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}.
Q9NZ01 TECR S49 Sugiyama Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234). {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:25049234}.
Q93052 LPP S537 Sugiyama Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
P20248 CCNA2 S130 Sugiyama Cyclin-A2 (Cyclin-A) (Cyclin A) Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}.
P45985 MAP2K4 S55 Sugiyama Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.
Q6PJT7 ZC3H14 S330 Sugiyama Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}.
Q86Y07 VRK2 S190 Sugiyama Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}.
Q9NSE4 IARS2 S176 Sugiyama Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). {ECO:0000250|UniProtKB:P00956}.
Q7Z7E8 UBE2Q1 S401 Sugiyama Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}.
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reactome_id name p -log10_p
R-HSA-3371568 Attenuation phase 3.019807e-14 13.520
R-HSA-3371571 HSF1-dependent transactivation 4.215517e-13 12.375
R-HSA-3371511 HSF1 activation 1.094980e-11 10.961
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 4.888590e-11 10.311
R-HSA-3371556 Cellular response to heat stress 4.174751e-10 9.379
R-HSA-69278 Cell Cycle, Mitotic 1.593609e-06 5.798
R-HSA-2262752 Cellular responses to stress 2.057309e-06 5.687
R-HSA-1640170 Cell Cycle 2.686270e-06 5.571
R-HSA-8953897 Cellular responses to stimuli 1.593133e-05 4.798
R-HSA-1538133 G0 and Early G1 2.770578e-05 4.557
R-HSA-3700989 Transcriptional Regulation by TP53 3.696779e-05 4.432
R-HSA-8953750 Transcriptional Regulation by E2F6 6.798925e-05 4.168
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.435439e-04 3.613
R-HSA-2559580 Oxidative Stress Induced Senescence 6.047152e-04 3.218
R-HSA-72163 mRNA Splicing - Major Pathway 7.515609e-04 3.124
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 8.357317e-04 3.078
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 1.579664e-03 2.801
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 1.765313e-03 2.753
R-HSA-72172 mRNA Splicing 1.035671e-03 2.985
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.656280e-03 2.781
R-HSA-2559583 Cellular Senescence 2.311049e-03 2.636
R-HSA-450294 MAP kinase activation 3.688309e-03 2.433
R-HSA-68886 M Phase 3.727216e-03 2.429
R-HSA-3214847 HATs acetylate histones 3.364287e-03 2.473
R-HSA-9930044 Nuclear RNA decay 5.473256e-03 2.262
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 5.473256e-03 2.262
R-HSA-450341 Activation of the AP-1 family of transcription factors 5.401633e-03 2.267
R-HSA-448424 Interleukin-17 signaling 5.661763e-03 2.247
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 4.565606e-03 2.341
R-HSA-5633007 Regulation of TP53 Activity 5.759436e-03 2.240
R-HSA-5696400 Dual Incision in GG-NER 6.277003e-03 2.202
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 6.302323e-03 2.200
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 7.920487e-03 2.101
R-HSA-3247509 Chromatin modifying enzymes 8.513430e-03 2.070
R-HSA-3214841 PKMTs methylate histone lysines 9.624621e-03 2.017
R-HSA-141424 Amplification of signal from the kinetochores 1.070311e-02 1.970
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.070311e-02 1.970
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 9.955991e-03 2.002
R-HSA-8953854 Metabolism of RNA 1.063317e-02 1.973
R-HSA-69275 G2/M Transition 1.105921e-02 1.956
R-HSA-4839726 Chromatin organization 1.139863e-02 1.943
R-HSA-453274 Mitotic G2-G2/M phases 1.155491e-02 1.937
R-HSA-68877 Mitotic Prometaphase 1.286257e-02 1.891
R-HSA-69620 Cell Cycle Checkpoints 1.343800e-02 1.872
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 1.784897e-02 1.748
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 1.784897e-02 1.748
R-HSA-9673013 Diseases of Telomere Maintenance 1.784897e-02 1.748
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 1.784897e-02 1.748
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 1.784897e-02 1.748
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 1.784897e-02 1.748
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 1.784897e-02 1.748
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.692104e-02 1.772
R-HSA-975871 MyD88 cascade initiated on plasma membrane 1.747064e-02 1.758
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 1.747064e-02 1.758
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 1.747064e-02 1.758
R-HSA-5210891 Uptake and function of anthrax toxins 1.712394e-02 1.766
R-HSA-69618 Mitotic Spindle Checkpoint 1.853491e-02 1.732
R-HSA-156711 Polo-like kinase mediated events 1.860732e-02 1.730
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.975074e-02 1.704
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 2.057336e-02 1.687
R-HSA-68882 Mitotic Anaphase 2.060322e-02 1.686
R-HSA-2555396 Mitotic Metaphase and Anaphase 2.098172e-02 1.678
R-HSA-74160 Gene expression (Transcription) 1.919372e-02 1.717
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.141461e-02 1.669
R-HSA-5696398 Nucleotide Excision Repair 2.196604e-02 1.658
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 2.196604e-02 1.658
R-HSA-6782135 Dual incision in TC-NER 2.227449e-02 1.652
R-HSA-5674404 PTEN Loss of Function in Cancer 2.665445e-02 1.574
R-HSA-8943724 Regulation of PTEN gene transcription 2.405019e-02 1.619
R-HSA-2467813 Separation of Sister Chromatids 2.510495e-02 1.600
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.445540e-02 1.612
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.319032e-02 1.635
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 2.381774e-02 1.623
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.678676e-02 1.572
R-HSA-9700206 Signaling by ALK in cancer 2.319032e-02 1.635
R-HSA-975155 MyD88 dependent cascade initiated on endosome 2.445540e-02 1.612
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 2.510332e-02 1.600
R-HSA-166166 MyD88-independent TLR4 cascade 2.510332e-02 1.600
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 2.710898e-02 1.567
R-HSA-8943723 Regulation of PTEN mRNA translation 2.856807e-02 1.544
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.920806e-02 1.534
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2.920806e-02 1.534
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 3.039555e-02 1.517
R-HSA-4755609 Defective DHDDS causes RP59 3.538151e-02 1.451
R-HSA-674695 RNA Polymerase II Pre-transcription Events 3.855560e-02 1.414
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 3.514402e-02 1.454
R-HSA-453276 Regulation of mitotic cell cycle 3.514402e-02 1.454
R-HSA-69473 G2/M DNA damage checkpoint 3.855560e-02 1.414
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.447256e-02 1.463
R-HSA-400685 Sema4D in semaphorin signaling 3.226825e-02 1.491
R-HSA-68875 Mitotic Prophase 3.368890e-02 1.473
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 3.291580e-02 1.483
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 3.291580e-02 1.483
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 3.526679e-02 1.453
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 3.526679e-02 1.453
R-HSA-73857 RNA Polymerase II Transcription 3.397771e-02 1.469
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 3.614551e-02 1.442
R-HSA-5688426 Deubiquitination 3.903993e-02 1.408
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 3.972904e-02 1.401
R-HSA-9709570 Impaired BRCA2 binding to RAD51 4.019246e-02 1.396
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 4.019246e-02 1.396
R-HSA-212436 Generic Transcription Pathway 4.385955e-02 1.358
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 4.403087e-02 1.356
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 4.403087e-02 1.356
R-HSA-139910 Activation of BMF and translocation to mitochondria 4.403087e-02 1.356
R-HSA-111446 Activation of BIM and translocation to mitochondria 4.403087e-02 1.356
R-HSA-5693607 Processing of DNA double-strand break ends 4.714530e-02 1.327
R-HSA-68911 G2 Phase 6.109919e-02 1.214
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 5.328039e-02 1.273
R-HSA-5696394 DNA Damage Recognition in GG-NER 5.100543e-02 1.292
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 5.328039e-02 1.273
R-HSA-6807070 PTEN Regulation 5.337616e-02 1.273
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 4.876681e-02 1.312
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 5.328039e-02 1.273
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 6.272728e-02 1.203
R-HSA-73894 DNA Repair 5.718401e-02 1.243
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 5.559085e-02 1.255
R-HSA-9007892 Interleukin-38 signaling 5.260320e-02 1.279
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 4.876681e-02 1.312
R-HSA-9768919 NPAS4 regulates expression of target genes 5.328039e-02 1.273
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.401011e-02 1.194
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 6.764792e-02 1.170
R-HSA-5696395 Formation of Incision Complex in GG-NER 6.764792e-02 1.170
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 6.764792e-02 1.170
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 6.764792e-02 1.170
R-HSA-5674499 Negative feedback regulation of MAPK pathway 6.951951e-02 1.158
R-HSA-5693532 DNA Double-Strand Break Repair 6.971433e-02 1.157
R-HSA-167161 HIV Transcription Initiation 7.269186e-02 1.139
R-HSA-75953 RNA Polymerase II Transcription Initiation 7.269186e-02 1.139
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 7.269186e-02 1.139
R-HSA-157579 Telomere Maintenance 7.469152e-02 1.127
R-HSA-73776 RNA Polymerase II Promoter Escape 7.785320e-02 1.109
R-HSA-69478 G2/M DNA replication checkpoint 7.786482e-02 1.109
R-HSA-8948747 Regulation of PTEN localization 8.613581e-02 1.065
R-HSA-9732724 IFNG signaling activates MAPKs 8.613581e-02 1.065
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 8.613581e-02 1.065
R-HSA-9660537 Signaling by MRAS-complex mutants 9.433311e-02 1.025
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 9.433311e-02 1.025
R-HSA-9706019 RHOBTB3 ATPase cycle 1.184894e-01 0.926
R-HSA-5656121 Translesion synthesis by POLI 1.648990e-01 0.783
R-HSA-5655862 Translesion synthesis by POLK 1.723944e-01 0.763
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.723944e-01 0.763
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.871855e-01 0.728
R-HSA-9709603 Impaired BRCA2 binding to PALB2 1.944822e-01 0.711
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 2.017139e-01 0.695
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.017139e-01 0.695
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 2.017139e-01 0.695
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.017139e-01 0.695
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.088812e-01 0.680
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 2.159845e-01 0.666
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.023823e-01 0.990
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.052261e-01 0.978
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 2.437699e-01 0.613
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 1.138832e-01 0.944
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.408506e-01 0.851
R-HSA-8854518 AURKA Activation by TPX2 1.439273e-01 0.842
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.176737e-01 0.662
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 2.275686e-01 0.643
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.308743e-01 0.637
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.441261e-01 0.612
R-HSA-193648 NRAGE signals death through JNK 1.138832e-01 0.944
R-HSA-73893 DNA Damage Bypass 9.398518e-02 1.027
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 8.312622e-02 1.080
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.110993e-01 0.676
R-HSA-110312 Translesion synthesis by REV1 1.573361e-01 0.803
R-HSA-156902 Peptide chain elongation 2.176737e-01 0.662
R-HSA-2465910 MASTL Facilitates Mitotic Progression 1.024574e-01 0.989
R-HSA-69091 Polymerase switching 1.342371e-01 0.872
R-HSA-69109 Leading Strand Synthesis 1.342371e-01 0.872
R-HSA-110320 Translesion Synthesis by POLH 1.944822e-01 0.711
R-HSA-6802957 Oncogenic MAPK signaling 2.045457e-01 0.689
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 1.626678e-01 0.789
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.723944e-01 0.763
R-HSA-174411 Polymerase switching on the C-strand of the telomere 2.437699e-01 0.613
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 1.059368e-01 0.975
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 2.159845e-01 0.666
R-HSA-5693538 Homology Directed Repair 1.173281e-01 0.931
R-HSA-212165 Epigenetic regulation of gene expression 1.981184e-01 0.703
R-HSA-5685942 HDR through Homologous Recombination (HRR) 1.470181e-01 0.833
R-HSA-380615 Serotonin clearance from the synaptic cleft 1.342371e-01 0.872
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.871855e-01 0.728
R-HSA-156842 Eukaryotic Translation Elongation 2.341833e-01 0.630
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.427973e-01 0.615
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.658335e-01 0.780
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 8.580286e-02 1.066
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.501227e-01 0.824
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 1.263985e-01 0.898
R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 1.263985e-01 0.898
R-HSA-9664420 Killing mechanisms 1.648990e-01 0.783
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.648990e-01 0.783
R-HSA-69242 S Phase 1.891765e-01 0.723
R-HSA-446353 Cell-extracellular matrix interactions 1.573361e-01 0.803
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 1.317105e-01 0.880
R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.051766e-01 0.688
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.227165e-01 0.911
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 1.439273e-01 0.842
R-HSA-69186 Lagging Strand Synthesis 2.088812e-01 0.680
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.369166e-01 0.625
R-HSA-5689603 UCH proteinases 1.753939e-01 0.756
R-HSA-73886 Chromosome Maintenance 1.231894e-01 0.909
R-HSA-167172 Transcription of the HIV genome 1.501227e-01 0.824
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 8.613581e-02 1.065
R-HSA-69202 Cyclin E associated events during G1/S transition 1.563708e-01 0.806
R-HSA-69481 G2/M Checkpoints 1.372673e-01 0.862
R-HSA-8951664 Neddylation 1.735734e-01 0.761
R-HSA-2980766 Nuclear Envelope Breakdown 1.168088e-01 0.933
R-HSA-5693606 DNA Double Strand Break Response 1.470181e-01 0.833
R-HSA-430116 GP1b-IX-V activation signalling 1.024574e-01 0.989
R-HSA-180786 Extension of Telomeres 1.227165e-01 0.911
R-HSA-9675135 Diseases of DNA repair 8.580286e-02 1.066
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.420058e-01 0.848
R-HSA-5620916 VxPx cargo-targeting to cilium 2.017139e-01 0.695
R-HSA-2871796 FCERI mediated MAPK activation 1.022421e-01 0.990
R-HSA-162599 Late Phase of HIV Life Cycle 1.757372e-01 0.755
R-HSA-9675151 Disorders of Developmental Biology 1.723944e-01 0.763
R-HSA-1483249 Inositol phosphate metabolism 1.022421e-01 0.990
R-HSA-9659379 Sensory processing of sound 1.850402e-01 0.733
R-HSA-205043 NRIF signals cell death from the nucleus 1.497053e-01 0.825
R-HSA-392517 Rap1 signalling 1.944822e-01 0.711
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2.017139e-01 0.695
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.159845e-01 0.666
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.501227e-01 0.824
R-HSA-168255 Influenza Infection 1.047756e-01 0.980
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 1.024574e-01 0.989
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1.497053e-01 0.825
R-HSA-446199 Synthesis of dolichyl-phosphate 2.369166e-01 0.625
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.138832e-01 0.944
R-HSA-162587 HIV Life Cycle 2.098052e-01 0.678
R-HSA-9662834 CD163 mediating an anti-inflammatory response 1.184894e-01 0.926
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.122952e-01 0.950
R-HSA-9629569 Protein hydroxylation 2.017139e-01 0.695
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.369166e-01 0.625
R-HSA-8863678 Neurodegenerative Diseases 2.369166e-01 0.625
R-HSA-9645723 Diseases of programmed cell death 2.176737e-01 0.662
R-HSA-373755 Semaphorin interactions 1.347416e-01 0.870
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.658335e-01 0.780
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1.648990e-01 0.783
R-HSA-9833482 PKR-mediated signaling 1.882727e-01 0.725
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.028715e-01 0.693
R-HSA-168898 Toll-like Receptor Cascades 1.225107e-01 0.912
R-HSA-5339562 Uptake and actions of bacterial toxins 1.023823e-01 0.990
R-HSA-109581 Apoptosis 2.214762e-01 0.655
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 1.408506e-01 0.851
R-HSA-8986944 Transcriptional Regulation by MECP2 2.275686e-01 0.643
R-HSA-9634815 Transcriptional Regulation by NPAS4 1.023823e-01 0.990
R-HSA-9020591 Interleukin-12 signaling 1.753939e-01 0.756
R-HSA-447115 Interleukin-12 family signaling 2.143841e-01 0.669
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.474446e-01 0.607
R-HSA-72764 Eukaryotic Translation Termination 2.474446e-01 0.607
R-HSA-72689 Formation of a pool of free 40S subunits 2.474446e-01 0.607
R-HSA-422475 Axon guidance 2.496236e-01 0.603
R-HSA-5689880 Ub-specific processing proteases 2.499803e-01 0.602
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.505620e-01 0.601
R-HSA-5689901 Metalloprotease DUBs 2.505620e-01 0.601
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 2.505620e-01 0.601
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 2.505620e-01 0.601
R-HSA-445095 Interaction between L1 and Ankyrins 2.572936e-01 0.590
R-HSA-73863 RNA Polymerase I Transcription Termination 2.572936e-01 0.590
R-HSA-3928663 EPHA-mediated growth cone collapse 2.572936e-01 0.590
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.572936e-01 0.590
R-HSA-264876 Insulin processing 2.572936e-01 0.590
R-HSA-193704 p75 NTR receptor-mediated signalling 2.607324e-01 0.584
R-HSA-171319 Telomere Extension By Telomerase 2.639651e-01 0.578
R-HSA-70171 Glycolysis 2.640563e-01 0.578
R-HSA-2408557 Selenocysteine synthesis 2.673804e-01 0.573
R-HSA-5656169 Termination of translesion DNA synthesis 2.705771e-01 0.568
R-HSA-9842860 Regulation of endogenous retroelements 2.707044e-01 0.568
R-HSA-1483255 PI Metabolism 2.707044e-01 0.568
R-HSA-192823 Viral mRNA Translation 2.740282e-01 0.562
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.771302e-01 0.557
R-HSA-112311 Neurotransmitter clearance 2.771302e-01 0.557
R-HSA-114452 Activation of BH3-only proteins 2.771302e-01 0.557
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.773513e-01 0.557
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 2.806737e-01 0.552
R-HSA-5619507 Activation of HOX genes during differentiation 2.806737e-01 0.552
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.836247e-01 0.547
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.836247e-01 0.547
R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.863126e-01 0.543
R-HSA-9675126 Diseases of mitotic cell cycle 2.900613e-01 0.538
R-HSA-69190 DNA strand elongation 2.900613e-01 0.538
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.900613e-01 0.538
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.906333e-01 0.537
R-HSA-69239 Synthesis of DNA 2.906333e-01 0.537
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.939499e-01 0.532
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.939499e-01 0.532
R-HSA-1855170 IPs transport between nucleus and cytosol 2.964404e-01 0.528
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.964404e-01 0.528
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.964404e-01 0.528
R-HSA-1839124 FGFR1 mutant receptor activation 2.964404e-01 0.528
R-HSA-176187 Activation of ATR in response to replication stress 2.964404e-01 0.528
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 2.964404e-01 0.528
R-HSA-9733709 Cardiogenesis 2.964404e-01 0.528
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 2.964404e-01 0.528
R-HSA-9675108 Nervous system development 3.012260e-01 0.521
R-HSA-390522 Striated Muscle Contraction 3.027627e-01 0.519
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.027627e-01 0.519
R-HSA-5693537 Resolution of D-Loop Structures 3.027627e-01 0.519
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 3.027627e-01 0.519
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.027627e-01 0.519
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.071937e-01 0.513
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.071937e-01 0.513
R-HSA-5673000 RAF activation 3.090285e-01 0.510
R-HSA-180746 Nuclear import of Rev protein 3.090285e-01 0.510
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.152384e-01 0.501
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.152384e-01 0.501
R-HSA-1257604 PIP3 activates AKT signaling 3.158073e-01 0.501
R-HSA-212300 PRC2 methylates histones and DNA 3.213928e-01 0.493
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.213928e-01 0.493
R-HSA-69205 G1/S-Specific Transcription 3.213928e-01 0.493
R-HSA-6804757 Regulation of TP53 Degradation 3.213928e-01 0.493
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 3.230484e-01 0.491
R-HSA-376176 Signaling by ROBO receptors 3.230484e-01 0.491
R-HSA-72613 Eukaryotic Translation Initiation 3.269675e-01 0.485
R-HSA-72737 Cap-dependent Translation Initiation 3.269675e-01 0.485
R-HSA-373760 L1CAM interactions 3.269675e-01 0.485
R-HSA-1296072 Voltage gated Potassium channels 3.274923e-01 0.485
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.274923e-01 0.485
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.274923e-01 0.485
R-HSA-5689896 Ovarian tumor domain proteases 3.274923e-01 0.485
R-HSA-70326 Glucose metabolism 3.302499e-01 0.481
R-HSA-5357801 Programmed Cell Death 3.304113e-01 0.481
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.335374e-01 0.477
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.395285e-01 0.469
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.395285e-01 0.469
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 3.395285e-01 0.469
R-HSA-6806003 Regulation of TP53 Expression and Degradation 3.395285e-01 0.469
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.454661e-01 0.462
R-HSA-9670095 Inhibition of DNA recombination at telomere 3.454661e-01 0.462
R-HSA-177243 Interactions of Rev with host cellular proteins 3.454661e-01 0.462
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.454661e-01 0.462
R-HSA-379726 Mitochondrial tRNA aminoacylation 3.454661e-01 0.462
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 3.513507e-01 0.454
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.513507e-01 0.454
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.513507e-01 0.454
R-HSA-9656223 Signaling by RAF1 mutants 3.571827e-01 0.447
R-HSA-5674135 MAP2K and MAPK activation 3.571827e-01 0.447
R-HSA-5675221 Negative regulation of MAPK pathway 3.571827e-01 0.447
R-HSA-5655302 Signaling by FGFR1 in disease 3.571827e-01 0.447
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 3.571827e-01 0.447
R-HSA-442660 SLC-mediated transport of neurotransmitters 3.571827e-01 0.447
R-HSA-69206 G1/S Transition 3.595743e-01 0.444
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.629627e-01 0.440
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 3.629627e-01 0.440
R-HSA-9710421 Defective pyroptosis 3.686911e-01 0.433
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 3.686911e-01 0.433
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 3.743683e-01 0.427
R-HSA-156581 Methylation 3.743683e-01 0.427
R-HSA-3214858 RMTs methylate histone arginines 3.743683e-01 0.427
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.799948e-01 0.420
R-HSA-9843745 Adipogenesis 3.820604e-01 0.418
R-HSA-162906 HIV Infection 3.842068e-01 0.415
R-HSA-9649948 Signaling downstream of RAS mutants 3.855710e-01 0.414
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.855710e-01 0.414
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.855710e-01 0.414
R-HSA-6802949 Signaling by RAS mutants 3.855710e-01 0.414
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 3.855710e-01 0.414
R-HSA-75153 Apoptotic execution phase 3.855710e-01 0.414
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.910974e-01 0.408
R-HSA-437239 Recycling pathway of L1 3.910974e-01 0.408
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 3.910974e-01 0.408
R-HSA-72312 rRNA processing 3.963245e-01 0.402
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.965745e-01 0.402
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 3.965745e-01 0.402
R-HSA-70263 Gluconeogenesis 3.965745e-01 0.402
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 4.020026e-01 0.396
R-HSA-69563 p53-Dependent G1 DNA Damage Response 4.020026e-01 0.396
R-HSA-9948299 Ribosome-associated quality control 4.073436e-01 0.390
R-HSA-5658442 Regulation of RAS by GAPs 4.073823e-01 0.390
R-HSA-9006925 Intracellular signaling by second messengers 4.113794e-01 0.386
R-HSA-912446 Meiotic recombination 4.127139e-01 0.384
R-HSA-9864848 Complex IV assembly 4.127139e-01 0.384
R-HSA-73772 RNA Polymerase I Promoter Escape 4.179978e-01 0.379
R-HSA-112382 Formation of RNA Pol II elongation complex 4.179978e-01 0.379
R-HSA-68949 Orc1 removal from chromatin 4.179978e-01 0.379
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 4.232345e-01 0.373
R-HSA-8948751 Regulation of PTEN stability and activity 4.232345e-01 0.373
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.232345e-01 0.373
R-HSA-1221632 Meiotic synapsis 4.232345e-01 0.373
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 4.232345e-01 0.373
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.284244e-01 0.368
R-HSA-6798695 Neutrophil degranulation 4.312455e-01 0.365
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.386656e-01 0.358
R-HSA-3299685 Detoxification of Reactive Oxygen Species 4.386656e-01 0.358
R-HSA-9856651 MITF-M-dependent gene expression 4.473325e-01 0.349
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.533526e-01 0.344
R-HSA-446652 Interleukin-1 family signaling 4.533526e-01 0.344
R-HSA-194441 Metabolism of non-coding RNA 4.536865e-01 0.343
R-HSA-191859 snRNP Assembly 4.536865e-01 0.343
R-HSA-69306 DNA Replication 4.563488e-01 0.341
R-HSA-983189 Kinesins 4.586042e-01 0.339
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.586042e-01 0.339
R-HSA-379724 tRNA Aminoacylation 4.586042e-01 0.339
R-HSA-73887 Death Receptor Signaling 4.593357e-01 0.338
R-HSA-168325 Viral Messenger RNA Synthesis 4.634780e-01 0.334
R-HSA-6784531 tRNA processing in the nucleus 4.683082e-01 0.329
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.683082e-01 0.329
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.683082e-01 0.329
R-HSA-9707616 Heme signaling 4.683082e-01 0.329
R-HSA-9711097 Cellular response to starvation 4.711881e-01 0.327
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.730952e-01 0.325
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.730952e-01 0.325
R-HSA-8848021 Signaling by PTK6 4.730952e-01 0.325
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.730952e-01 0.325
R-HSA-69615 G1/S DNA Damage Checkpoints 4.730952e-01 0.325
R-HSA-9711123 Cellular response to chemical stress 4.812341e-01 0.318
R-HSA-2408522 Selenoamino acid metabolism 4.886743e-01 0.311
R-HSA-913531 Interferon Signaling 4.945065e-01 0.306
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 4.963958e-01 0.304
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.054268e-01 0.296
R-HSA-75105 Fatty acyl-CoA biosynthesis 5.054268e-01 0.296
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.098818e-01 0.293
R-HSA-427413 NoRC negatively regulates rRNA expression 5.098818e-01 0.293
R-HSA-5620920 Cargo trafficking to the periciliary membrane 5.098818e-01 0.293
R-HSA-9909648 Regulation of PD-L1(CD274) expression 5.142217e-01 0.289
R-HSA-5578749 Transcriptional regulation by small RNAs 5.142970e-01 0.289
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.142970e-01 0.289
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.186727e-01 0.285
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.186727e-01 0.285
R-HSA-69052 Switching of origins to a post-replicative state 5.186727e-01 0.285
R-HSA-1226099 Signaling by FGFR in disease 5.230092e-01 0.281
R-HSA-449147 Signaling by Interleukins 5.272523e-01 0.278
R-HSA-380287 Centrosome maturation 5.273069e-01 0.278
R-HSA-1169408 ISG15 antiviral mechanism 5.273069e-01 0.278
R-HSA-1280215 Cytokine Signaling in Immune system 5.282842e-01 0.277
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.315662e-01 0.274
R-HSA-73864 RNA Polymerase I Transcription 5.399707e-01 0.268
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 5.482255e-01 0.261
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.482255e-01 0.261
R-HSA-597592 Post-translational protein modification 5.537297e-01 0.257
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 5.563331e-01 0.255
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 5.563331e-01 0.255
R-HSA-9707564 Cytoprotection by HMOX1 5.603325e-01 0.252
R-HSA-5617833 Cilium Assembly 5.627502e-01 0.250
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 5.642962e-01 0.248
R-HSA-1500620 Meiosis 5.682243e-01 0.245
R-HSA-5687128 MAPK6/MAPK4 signaling 5.682243e-01 0.245
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 5.759755e-01 0.240
R-HSA-9609690 HCMV Early Events 5.781443e-01 0.238
R-HSA-390466 Chaperonin-mediated protein folding 5.797990e-01 0.237
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 5.881869e-01 0.230
R-HSA-389948 Co-inhibition by PD-1 5.881869e-01 0.230
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.910655e-01 0.228
R-HSA-73884 Base Excision Repair 5.910655e-01 0.228
R-HSA-202424 Downstream TCR signaling 5.910655e-01 0.228
R-HSA-391251 Protein folding 6.020320e-01 0.220
R-HSA-2682334 EPH-Ephrin signaling 6.020320e-01 0.220
R-HSA-9837999 Mitochondrial protein degradation 6.091802e-01 0.215
R-HSA-6807878 COPI-mediated anterograde transport 6.196641e-01 0.208
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 6.196641e-01 0.208
R-HSA-1296071 Potassium Channels 6.196641e-01 0.208
R-HSA-9730414 MITF-M-regulated melanocyte development 6.219446e-01 0.206
R-HSA-422356 Regulation of insulin secretion 6.264977e-01 0.203
R-HSA-9020702 Interleukin-1 signaling 6.365201e-01 0.196
R-HSA-5683057 MAPK family signaling cascades 6.445248e-01 0.191
R-HSA-8878171 Transcriptional regulation by RUNX1 6.513596e-01 0.186
R-HSA-211000 Gene Silencing by RNA 6.588791e-01 0.181
R-HSA-2672351 Stimuli-sensing channels 6.619597e-01 0.179
R-HSA-202403 TCR signaling 6.680383e-01 0.175
R-HSA-168249 Innate Immune System 6.786195e-01 0.168
R-HSA-2980736 Peptide hormone metabolism 6.940759e-01 0.159
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.968407e-01 0.157
R-HSA-9609646 HCMV Infection 7.008797e-01 0.154
R-HSA-2132295 MHC class II antigen presentation 7.102969e-01 0.149
R-HSA-388841 Regulation of T cell activation by CD28 family 7.123174e-01 0.147
R-HSA-162909 Host Interactions of HIV factors 7.129161e-01 0.147
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.180841e-01 0.144
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.180841e-01 0.144
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.180841e-01 0.144
R-HSA-114608 Platelet degranulation 7.231598e-01 0.141
R-HSA-199991 Membrane Trafficking 7.238484e-01 0.140
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.306036e-01 0.136
R-HSA-1474165 Reproduction 7.330404e-01 0.135
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 7.354553e-01 0.133
R-HSA-8856688 Golgi-to-ER retrograde transport 7.378486e-01 0.132
R-HSA-9909396 Circadian clock 7.378486e-01 0.132
R-HSA-1474228 Degradation of the extracellular matrix 7.378486e-01 0.132
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.402203e-01 0.131
R-HSA-76002 Platelet activation, signaling and aggregation 7.444645e-01 0.128
R-HSA-163685 Integration of energy metabolism 7.494960e-01 0.125
R-HSA-446728 Cell junction organization 7.511799e-01 0.124
R-HSA-9824443 Parasitic Infection Pathways 7.561172e-01 0.121
R-HSA-9658195 Leishmania infection 7.561172e-01 0.121
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.577442e-01 0.120
R-HSA-9664407 Parasite infection 7.584427e-01 0.120
R-HSA-9664422 FCGR3A-mediated phagocytosis 7.584427e-01 0.120
R-HSA-9664417 Leishmania phagocytosis 7.584427e-01 0.120
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 7.606293e-01 0.119
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 7.649438e-01 0.116
R-HSA-5673001 RAF/MAP kinase cascade 7.688746e-01 0.114
R-HSA-72766 Translation 7.735630e-01 0.112
R-HSA-199977 ER to Golgi Anterograde Transport 7.753951e-01 0.110
R-HSA-1483257 Phospholipid metabolism 7.780609e-01 0.109
R-HSA-5684996 MAPK1/MAPK3 signaling 7.795608e-01 0.108
R-HSA-392499 Metabolism of proteins 7.805270e-01 0.108
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.834227e-01 0.106
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 7.892559e-01 0.103
R-HSA-9610379 HCMV Late Events 7.949330e-01 0.100
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 7.949330e-01 0.100
R-HSA-877300 Interferon gamma signaling 7.986331e-01 0.098
R-HSA-1500931 Cell-Cell communication 8.077559e-01 0.093
R-HSA-5619102 SLC transporter disorders 8.127820e-01 0.090
R-HSA-1852241 Organelle biogenesis and maintenance 8.129976e-01 0.090
R-HSA-1643685 Disease 8.184925e-01 0.087
R-HSA-72306 tRNA processing 8.194817e-01 0.086
R-HSA-5621481 C-type lectin receptors (CLRs) 8.211190e-01 0.086
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.243497e-01 0.084
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.243497e-01 0.084
R-HSA-9664433 Leishmania parasite growth and survival 8.243497e-01 0.084
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.243497e-01 0.084
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 8.259432e-01 0.083
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 8.275223e-01 0.082
R-HSA-611105 Respiratory electron transport 8.321749e-01 0.080
R-HSA-3781865 Diseases of glycosylation 8.411095e-01 0.075
R-HSA-983712 Ion channel transport 8.481929e-01 0.072
R-HSA-1280218 Adaptive Immune System 8.521133e-01 0.070
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.575857e-01 0.067
R-HSA-948021 Transport to the Golgi and subsequent modification 8.651758e-01 0.063
R-HSA-5653656 Vesicle-mediated transport 8.720553e-01 0.059
R-HSA-397014 Muscle contraction 8.780625e-01 0.056
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.811641e-01 0.055
R-HSA-418990 Adherens junctions interactions 8.845680e-01 0.053
R-HSA-9824439 Bacterial Infection Pathways 8.870438e-01 0.052
R-HSA-9705683 SARS-CoV-2-host interactions 8.946533e-01 0.048
R-HSA-168256 Immune System 8.951753e-01 0.048
R-HSA-9824446 Viral Infection Pathways 8.983622e-01 0.047
R-HSA-156580 Phase II - Conjugation of compounds 9.047388e-01 0.043
R-HSA-446203 Asparagine N-linked glycosylation 9.106596e-01 0.041
R-HSA-5619115 Disorders of transmembrane transporters 9.114657e-01 0.040
R-HSA-1266738 Developmental Biology 9.120836e-01 0.040
R-HSA-5663205 Infectious disease 9.128101e-01 0.040
R-HSA-421270 Cell-cell junction organization 9.146500e-01 0.039
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.301422e-01 0.031
R-HSA-112316 Neuronal System 9.366615e-01 0.028
R-HSA-112315 Transmission across Chemical Synapses 9.559277e-01 0.020
R-HSA-162582 Signal Transduction 9.585960e-01 0.018
R-HSA-1474244 Extracellular matrix organization 9.590558e-01 0.018
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.626576e-01 0.017
R-HSA-9694516 SARS-CoV-2 Infection 9.653110e-01 0.015
R-HSA-109582 Hemostasis 9.778682e-01 0.010
R-HSA-425407 SLC-mediated transmembrane transport 9.779316e-01 0.010
R-HSA-8978868 Fatty acid metabolism 9.798808e-01 0.009
R-HSA-71291 Metabolism of amino acids and derivatives 9.802866e-01 0.009
R-HSA-5668914 Diseases of metabolism 9.832810e-01 0.007
R-HSA-211859 Biological oxidations 9.931473e-01 0.003
R-HSA-9679506 SARS-CoV Infections 9.949159e-01 0.002
R-HSA-382551 Transport of small molecules 9.990439e-01 0.000
R-HSA-9709957 Sensory Perception 9.998997e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999188e-01 0.000
R-HSA-1430728 Metabolism 9.999999e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.852 0.124 2 0.908
CLK3CLK3 0.851 0.229 1 0.717
ERK5ERK5 0.843 0.292 1 0.839
CDKL5CDKL5 0.842 0.218 -3 0.650
PIM3PIM3 0.839 0.092 -3 0.677
MST4MST4 0.838 0.143 2 0.917
PRPKPRPK 0.838 -0.019 -1 0.783
MOSMOS 0.838 0.103 1 0.784
CDKL1CDKL1 0.837 0.100 -3 0.655
NLKNLK 0.837 0.067 1 0.729
MTORMTOR 0.836 -0.024 1 0.743
WNK1WNK1 0.833 0.076 -2 0.904
CDC7CDC7 0.833 -0.051 1 0.747
GCN2GCN2 0.833 -0.079 2 0.813
RIPK3RIPK3 0.832 0.047 3 0.716
PKCDPKCD 0.832 0.145 2 0.880
ULK2ULK2 0.832 -0.054 2 0.823
NDR2NDR2 0.832 0.030 -3 0.686
MLK1MLK1 0.832 0.066 2 0.888
RAF1RAF1 0.832 -0.074 1 0.783
DSTYKDSTYK 0.832 -0.028 2 0.925
TBK1TBK1 0.831 -0.063 1 0.728
RSK2RSK2 0.831 0.096 -3 0.618
PKN2PKN2 0.831 0.095 -3 0.674
ICKICK 0.831 0.133 -3 0.701
HIPK4HIPK4 0.831 0.113 1 0.655
PKN3PKN3 0.830 0.046 -3 0.665
CAMK1BCAMK1B 0.830 0.016 -3 0.707
SKMLCKSKMLCK 0.830 0.104 -2 0.920
NUAK2NUAK2 0.830 0.033 -3 0.678
CHAK2CHAK2 0.830 0.040 -1 0.739
AURCAURC 0.829 0.193 -2 0.763
CAMLCKCAMLCK 0.829 0.135 -2 0.895
NDR1NDR1 0.829 0.046 -3 0.670
ATRATR 0.828 -0.021 1 0.723
PKACGPKACG 0.828 0.109 -2 0.799
IKKBIKKB 0.828 -0.106 -2 0.719
BMPR2BMPR2 0.828 -0.119 -2 0.849
IKKEIKKE 0.827 -0.086 1 0.713
NIKNIK 0.827 0.046 -3 0.727
PIM1PIM1 0.827 0.082 -3 0.613
GRK1GRK1 0.827 0.080 -2 0.786
RSK3RSK3 0.827 0.079 -3 0.610
KISKIS 0.826 0.045 1 0.594
NEK7NEK7 0.826 -0.055 -3 0.765
P90RSKP90RSK 0.826 0.048 -3 0.624
P70S6KBP70S6KB 0.826 0.087 -3 0.629
CAMK2GCAMK2G 0.826 -0.065 2 0.797
PDHK4PDHK4 0.826 -0.246 1 0.796
DAPK2DAPK2 0.826 0.084 -3 0.720
NEK6NEK6 0.826 -0.006 -2 0.821
SRPK1SRPK1 0.825 0.043 -3 0.605
AMPKA1AMPKA1 0.824 0.026 -3 0.692
TGFBR2TGFBR2 0.823 -0.054 -2 0.754
PRKD1PRKD1 0.823 0.032 -3 0.704
PKCAPKCA 0.823 0.138 2 0.840
PDHK1PDHK1 0.822 -0.187 1 0.791
MLK2MLK2 0.822 0.055 2 0.877
PKCGPKCG 0.822 0.110 2 0.848
ULK1ULK1 0.822 -0.094 -3 0.744
PAK3PAK3 0.822 0.118 -2 0.857
WNK3WNK3 0.822 -0.078 1 0.761
PAK1PAK1 0.822 0.120 -2 0.873
PRKD2PRKD2 0.821 0.039 -3 0.624
MARK4MARK4 0.821 -0.008 4 0.837
PKCBPKCB 0.821 0.105 2 0.850
MLK3MLK3 0.820 0.089 2 0.850
AURBAURB 0.820 0.170 -2 0.761
RSK4RSK4 0.820 0.110 -3 0.582
NEK9NEK9 0.820 -0.038 2 0.881
CLK4CLK4 0.819 0.111 -3 0.599
PKCHPKCH 0.819 0.098 2 0.824
CLK1CLK1 0.819 0.105 -3 0.582
MSK2MSK2 0.819 0.048 -3 0.597
MNK2MNK2 0.819 0.100 -2 0.860
GRK5GRK5 0.818 -0.143 -3 0.726
PKG2PKG2 0.818 0.143 -2 0.749
MAPKAPK3MAPKAPK3 0.818 -0.020 -3 0.627
AMPKA2AMPKA2 0.818 0.022 -3 0.655
MYLK4MYLK4 0.818 0.111 -2 0.849
PKACBPKACB 0.817 0.141 -2 0.762
HUNKHUNK 0.817 -0.101 2 0.816
DYRK2DYRK2 0.817 0.049 1 0.587
CDK8CDK8 0.817 -0.005 1 0.540
ANKRD3ANKRD3 0.817 -0.047 1 0.807
IRE1IRE1 0.817 -0.008 1 0.730
RIPK1RIPK1 0.816 -0.088 1 0.773
MASTLMASTL 0.816 -0.181 -2 0.810
SRPK2SRPK2 0.816 0.030 -3 0.522
DLKDLK 0.816 -0.102 1 0.788
MSK1MSK1 0.816 0.101 -3 0.594
PKCZPKCZ 0.815 0.064 2 0.855
CLK2CLK2 0.815 0.139 -3 0.578
MNK1MNK1 0.815 0.087 -2 0.860
PAK2PAK2 0.815 0.101 -2 0.857
SGK3SGK3 0.815 0.099 -3 0.591
GRK6GRK6 0.815 -0.086 1 0.783
HIPK1HIPK1 0.814 0.083 1 0.605
CAMK2DCAMK2D 0.814 -0.067 -3 0.696
CDK19CDK19 0.814 0.008 1 0.501
PAK6PAK6 0.814 0.129 -2 0.796
GRK7GRK7 0.813 0.055 1 0.737
AKT2AKT2 0.813 0.083 -3 0.527
CAMK4CAMK4 0.813 -0.030 -3 0.650
CDK7CDK7 0.813 -0.004 1 0.546
NIM1NIM1 0.813 -0.056 3 0.729
CDK1CDK1 0.813 0.039 1 0.510
BCKDKBCKDK 0.813 -0.156 -1 0.728
PIM2PIM2 0.813 0.101 -3 0.582
TSSK2TSSK2 0.812 -0.024 -5 0.786
IKKAIKKA 0.812 -0.100 -2 0.705
PHKG1PHKG1 0.812 0.005 -3 0.662
HIPK2HIPK2 0.812 0.069 1 0.486
PKRPKR 0.812 0.034 1 0.768
IRE2IRE2 0.812 0.019 2 0.815
SRPK3SRPK3 0.812 0.006 -3 0.572
YSK4YSK4 0.812 -0.030 1 0.741
LATS2LATS2 0.812 -0.057 -5 0.747
TSSK1TSSK1 0.812 -0.018 -3 0.715
MLK4MLK4 0.811 0.001 2 0.801
CDK5CDK5 0.811 0.047 1 0.560
TTBK2TTBK2 0.811 -0.137 2 0.738
P38AP38A 0.811 0.067 1 0.635
NEK2NEK2 0.811 -0.000 2 0.865
CHAK1CHAK1 0.810 -0.041 2 0.823
MST3MST3 0.810 0.121 2 0.914
MAPKAPK2MAPKAPK2 0.810 -0.023 -3 0.579
AURAAURA 0.810 0.139 -2 0.752
PRKD3PRKD3 0.810 0.008 -3 0.601
CDK18CDK18 0.810 0.025 1 0.488
LATS1LATS1 0.810 0.018 -3 0.714
P38BP38B 0.810 0.066 1 0.584
HIPK3HIPK3 0.809 0.072 1 0.629
NUAK1NUAK1 0.809 -0.047 -3 0.620
ALK4ALK4 0.809 -0.071 -2 0.778
GRK4GRK4 0.809 -0.150 -2 0.812
ERK1ERK1 0.809 0.038 1 0.557
PKCTPKCT 0.809 0.098 2 0.832
MELKMELK 0.809 -0.027 -3 0.640
TGFBR1TGFBR1 0.809 -0.038 -2 0.746
QIKQIK 0.809 -0.059 -3 0.682
BMPR1BBMPR1B 0.808 -0.003 1 0.718
MEK1MEK1 0.808 -0.110 2 0.865
VRK2VRK2 0.808 -0.056 1 0.805
QSKQSK 0.808 -0.011 4 0.817
PRKXPRKX 0.808 0.107 -3 0.500
PLK1PLK1 0.807 -0.083 -2 0.769
CDK3CDK3 0.807 0.091 1 0.453
CDK13CDK13 0.806 -0.037 1 0.528
CK1ECK1E 0.806 0.006 -3 0.475
SIKSIK 0.806 -0.035 -3 0.601
FAM20CFAM20C 0.805 0.002 2 0.577
AKT1AKT1 0.805 0.102 -3 0.542
DRAK1DRAK1 0.805 -0.031 1 0.720
MPSK1MPSK1 0.805 0.128 1 0.706
GSK3BGSK3B 0.805 0.113 4 0.554
PKACAPKACA 0.805 0.117 -2 0.713
ERK2ERK2 0.804 -0.009 1 0.592
CDK2CDK2 0.804 0.034 1 0.605
DYRK1ADYRK1A 0.804 0.026 1 0.624
JNK2JNK2 0.804 -0.003 1 0.510
CDK17CDK17 0.803 -0.005 1 0.435
ACVR2AACVR2A 0.803 -0.072 -2 0.733
CAMK1GCAMK1G 0.803 -0.016 -3 0.598
PKCEPKCE 0.803 0.124 2 0.836
P70S6KP70S6K 0.803 0.055 -3 0.546
CAMK2ACAMK2A 0.803 -0.040 2 0.783
SMMLCKSMMLCK 0.803 0.070 -3 0.657
CAMK2BCAMK2B 0.803 -0.067 2 0.756
ACVR2BACVR2B 0.803 -0.058 -2 0.742
PKCIPKCI 0.803 0.084 2 0.834
CDK10CDK10 0.803 0.053 1 0.512
JNK3JNK3 0.802 -0.023 1 0.550
WNK4WNK4 0.802 -0.025 -2 0.889
DYRK4DYRK4 0.802 0.046 1 0.506
IRAK4IRAK4 0.802 -0.001 1 0.757
MAKMAK 0.802 0.171 -2 0.872
ZAKZAK 0.802 -0.062 1 0.753
TAO3TAO3 0.802 0.034 1 0.752
PLK4PLK4 0.802 -0.074 2 0.637
SMG1SMG1 0.801 -0.068 1 0.667
ATMATM 0.801 -0.114 1 0.646
MEKK3MEKK3 0.801 -0.093 1 0.773
DYRK3DYRK3 0.801 0.073 1 0.607
SNRKSNRK 0.801 -0.103 2 0.703
BRSK2BRSK2 0.801 -0.065 -3 0.650
GSK3AGSK3A 0.800 0.109 4 0.560
MEK5MEK5 0.800 -0.108 2 0.866
CDK9CDK9 0.800 -0.045 1 0.543
MARK3MARK3 0.800 -0.023 4 0.788
CDK12CDK12 0.800 -0.037 1 0.506
CDK14CDK14 0.799 0.009 1 0.532
PHKG2PHKG2 0.799 0.003 -3 0.628
DYRK1BDYRK1B 0.799 0.024 1 0.534
NEK5NEK5 0.799 -0.006 1 0.782
MEKK1MEKK1 0.799 -0.087 1 0.764
HRIHRI 0.799 -0.101 -2 0.806
CDK16CDK16 0.798 0.029 1 0.454
PERKPERK 0.798 -0.104 -2 0.788
BRSK1BRSK1 0.798 -0.064 -3 0.626
PASKPASK 0.798 0.012 -3 0.709
MARK2MARK2 0.798 -0.045 4 0.765
MAPKAPK5MAPKAPK5 0.797 -0.112 -3 0.569
MEKK2MEKK2 0.797 -0.060 2 0.855
SSTKSSTK 0.797 0.031 4 0.792
DCAMKL1DCAMKL1 0.797 -0.041 -3 0.622
PLK3PLK3 0.797 -0.110 2 0.765
DNAPKDNAPK 0.797 -0.069 1 0.587
P38GP38G 0.796 -0.021 1 0.435
ALK2ALK2 0.796 -0.090 -2 0.753
NEK11NEK11 0.796 -0.032 1 0.753
CK1A2CK1A2 0.796 0.004 -3 0.427
AKT3AKT3 0.796 0.097 -3 0.475
GRK2GRK2 0.796 -0.086 -2 0.697
CK1DCK1D 0.796 -0.007 -3 0.434
ERK7ERK7 0.795 0.067 2 0.601
DAPK3DAPK3 0.795 0.090 -3 0.633
GAKGAK 0.795 0.047 1 0.780
BRAFBRAF 0.794 -0.123 -4 0.812
PAK5PAK5 0.794 0.085 -2 0.748
EEF2KEEF2K 0.794 0.091 3 0.831
PRP4PRP4 0.793 -0.045 -3 0.625
CK1G1CK1G1 0.793 -0.045 -3 0.468
MAP3K15MAP3K15 0.793 0.031 1 0.743
PAK4PAK4 0.793 0.104 -2 0.767
TAO2TAO2 0.793 0.012 2 0.911
TLK2TLK2 0.793 -0.158 1 0.686
GCKGCK 0.793 0.043 1 0.736
MOKMOK 0.792 0.131 1 0.667
MARK1MARK1 0.792 -0.081 4 0.796
SGK1SGK1 0.791 0.074 -3 0.448
MEKK6MEKK6 0.791 0.049 1 0.766
BUB1BUB1 0.791 0.162 -5 0.734
CHK1CHK1 0.791 -0.130 -3 0.668
TNIKTNIK 0.791 0.095 3 0.867
MRCKBMRCKB 0.790 0.105 -3 0.562
DCAMKL2DCAMKL2 0.790 -0.065 -3 0.648
HGKHGK 0.790 0.046 3 0.866
NEK8NEK8 0.790 -0.071 2 0.874
MINKMINK 0.790 0.035 1 0.752
NEK4NEK4 0.790 -0.014 1 0.750
DAPK1DAPK1 0.790 0.079 -3 0.613
PDK1PDK1 0.789 -0.028 1 0.776
HPK1HPK1 0.789 0.044 1 0.732
PKN1PKN1 0.789 0.018 -3 0.565
MRCKAMRCKA 0.789 0.099 -3 0.575
BMPR1ABMPR1A 0.789 -0.060 1 0.687
MST2MST2 0.789 -0.014 1 0.764
TTBK1TTBK1 0.789 -0.138 2 0.651
ROCK2ROCK2 0.788 0.111 -3 0.612
PINK1PINK1 0.787 -0.178 1 0.699
CAMKK1CAMKK1 0.787 -0.112 -2 0.714
IRAK1IRAK1 0.787 -0.171 -1 0.686
KHS1KHS1 0.786 0.070 1 0.735
P38DP38D 0.786 -0.005 1 0.431
CAMKK2CAMKK2 0.786 -0.066 -2 0.722
NEK1NEK1 0.786 0.031 1 0.774
LOKLOK 0.785 0.030 -2 0.765
CDK6CDK6 0.784 0.003 1 0.511
LKB1LKB1 0.784 -0.058 -3 0.715
KHS2KHS2 0.784 0.072 1 0.729
TAK1TAK1 0.784 -0.014 1 0.741
CAMK1DCAMK1D 0.784 -0.039 -3 0.507
TLK1TLK1 0.784 -0.184 -2 0.785
VRK1VRK1 0.783 -0.030 2 0.881
DMPK1DMPK1 0.783 0.128 -3 0.585
GRK3GRK3 0.783 -0.082 -2 0.655
LRRK2LRRK2 0.782 -0.057 2 0.881
MST1MST1 0.782 -0.008 1 0.755
PBKPBK 0.781 0.059 1 0.724
YSK1YSK1 0.781 0.016 2 0.874
CHK2CHK2 0.780 -0.034 -3 0.475
SLKSLK 0.780 -0.035 -2 0.707
CDK4CDK4 0.779 -0.017 1 0.487
JNK1JNK1 0.778 -0.052 1 0.496
HASPINHASPIN 0.778 0.039 -1 0.639
STK33STK33 0.778 -0.108 2 0.648
CAMK1ACAMK1A 0.778 -0.011 -3 0.497
CRIKCRIK 0.777 0.100 -3 0.551
RIPK2RIPK2 0.777 -0.151 1 0.729
ROCK1ROCK1 0.776 0.100 -3 0.571
MEK2MEK2 0.774 -0.152 2 0.838
PKG1PKG1 0.774 0.055 -2 0.669
CK2A2CK2A2 0.773 -0.033 1 0.639
PLK2PLK2 0.771 -0.089 -3 0.667
MYO3BMYO3B 0.769 0.048 2 0.887
OSR1OSR1 0.768 -0.036 2 0.851
NEK3NEK3 0.767 -0.082 1 0.743
ASK1ASK1 0.767 -0.044 1 0.734
CK2A1CK2A1 0.766 -0.025 1 0.620
MYO3AMYO3A 0.765 0.015 1 0.716
SBKSBK 0.765 -0.045 -3 0.421
TAO1TAO1 0.765 -0.017 1 0.699
BIKEBIKE 0.764 0.035 1 0.672
TTKTTK 0.763 -0.060 -2 0.796
PDHK3_TYRPDHK3_TYR 0.763 0.144 4 0.861
YANK3YANK3 0.760 -0.059 2 0.414
ALPHAK3ALPHAK3 0.758 -0.061 -1 0.679
CK1ACK1A 0.757 -0.043 -3 0.356
TESK1_TYRTESK1_TYR 0.757 0.053 3 0.855
PKMYT1_TYRPKMYT1_TYR 0.757 0.069 3 0.833
LIMK2_TYRLIMK2_TYR 0.755 0.130 -3 0.756
PDHK4_TYRPDHK4_TYR 0.753 0.008 2 0.888
EPHA6EPHA6 0.753 0.135 -1 0.778
PINK1_TYRPINK1_TYR 0.752 -0.006 1 0.796
BMPR2_TYRBMPR2_TYR 0.751 0.025 -1 0.812
MAP2K4_TYRMAP2K4_TYR 0.751 -0.063 -1 0.788
MAP2K7_TYRMAP2K7_TYR 0.751 -0.103 2 0.872
EPHB4EPHB4 0.750 0.113 -1 0.753
AAK1AAK1 0.750 0.073 1 0.575
MAP2K6_TYRMAP2K6_TYR 0.749 -0.055 -1 0.792
PDHK1_TYRPDHK1_TYR 0.748 -0.050 -1 0.800
TYRO3TYRO3 0.747 0.044 3 0.810
TXKTXK 0.747 0.100 1 0.801
ABL2ABL2 0.746 0.133 -1 0.711
TNK2TNK2 0.746 0.124 3 0.742
LIMK1_TYRLIMK1_TYR 0.746 -0.038 2 0.881
MST1RMST1R 0.746 -0.015 3 0.811
RETRET 0.746 -0.026 1 0.780
ROS1ROS1 0.745 0.014 3 0.773
DDR1DDR1 0.745 0.013 4 0.790
TYK2TYK2 0.745 -0.048 1 0.782
LCKLCK 0.744 0.121 -1 0.782
ITKITK 0.744 0.072 -1 0.744
STLK3STLK3 0.744 -0.180 1 0.724
CSF1RCSF1R 0.743 -0.019 3 0.803
JAK2JAK2 0.743 -0.022 1 0.782
YES1YES1 0.743 0.018 -1 0.763
ABL1ABL1 0.742 0.114 -1 0.703
HCKHCK 0.741 0.050 -1 0.775
FGRFGR 0.741 0.005 1 0.859
EPHB1EPHB1 0.741 0.041 1 0.830
BLKBLK 0.740 0.113 -1 0.775
TNNI3K_TYRTNNI3K_TYR 0.739 0.090 1 0.812
JAK1JAK1 0.739 0.033 1 0.737
JAK3JAK3 0.739 -0.035 1 0.768
BMXBMX 0.739 0.048 -1 0.695
TNK1TNK1 0.739 0.040 3 0.785
EPHB3EPHB3 0.738 0.036 -1 0.738
INSRRINSRR 0.738 -0.043 3 0.744
PDGFRBPDGFRB 0.737 -0.057 3 0.811
EPHB2EPHB2 0.737 0.022 -1 0.739
EPHA4EPHA4 0.737 -0.010 2 0.765
FYNFYN 0.737 0.086 -1 0.782
SRMSSRMS 0.736 -0.023 1 0.824
FERFER 0.735 -0.088 1 0.832
METMET 0.735 -0.000 3 0.788
MERTKMERTK 0.735 0.024 3 0.762
TECTEC 0.735 0.002 -1 0.683
KITKIT 0.735 -0.068 3 0.808
FLT3FLT3 0.735 -0.073 3 0.805
KDRKDR 0.735 -0.030 3 0.756
AXLAXL 0.733 -0.041 3 0.763
NEK10_TYRNEK10_TYR 0.733 -0.043 1 0.650
CK1G3CK1G3 0.733 -0.066 -3 0.311
WEE1_TYRWEE1_TYR 0.733 -0.033 -1 0.704
DDR2DDR2 0.732 0.098 3 0.722
BTKBTK 0.732 -0.063 -1 0.715
LTKLTK 0.730 0.004 3 0.748
EPHA1EPHA1 0.730 0.012 3 0.771
EPHA7EPHA7 0.730 0.006 2 0.772
PDGFRAPDGFRA 0.729 -0.113 3 0.817
ALKALK 0.729 -0.051 3 0.731
FGFR2FGFR2 0.729 -0.124 3 0.768
LYNLYN 0.729 -0.000 3 0.722
PTK2BPTK2B 0.728 0.024 -1 0.708
TEKTEK 0.728 -0.109 3 0.745
FGFR1FGFR1 0.727 -0.120 3 0.753
FRKFRK 0.727 -0.029 -1 0.769
EPHA3EPHA3 0.727 -0.050 2 0.741
NTRK2NTRK2 0.726 -0.103 3 0.756
YANK2YANK2 0.725 -0.094 2 0.434
FLT1FLT1 0.725 -0.077 -1 0.727
INSRINSR 0.724 -0.090 3 0.722
SRCSRC 0.723 -0.012 -1 0.750
ERBB2ERBB2 0.723 -0.126 1 0.754
NTRK1NTRK1 0.723 -0.154 -1 0.727
CK1G2CK1G2 0.722 -0.043 -3 0.392
EPHA5EPHA5 0.721 -0.034 2 0.748
NTRK3NTRK3 0.721 -0.089 -1 0.686
PTK6PTK6 0.721 -0.168 -1 0.644
PTK2PTK2 0.720 0.052 -1 0.742
FGFR3FGFR3 0.719 -0.131 3 0.748
EPHA8EPHA8 0.719 -0.032 -1 0.732
MATKMATK 0.718 -0.084 -1 0.638
FLT4FLT4 0.718 -0.153 3 0.746
MUSKMUSK 0.716 -0.050 1 0.697
SYKSYK 0.715 0.008 -1 0.720
CSKCSK 0.714 -0.107 2 0.773
EPHA2EPHA2 0.712 -0.026 -1 0.703
EGFREGFR 0.712 -0.091 1 0.699
IGF1RIGF1R 0.708 -0.106 3 0.665
FGFR4FGFR4 0.707 -0.124 -1 0.665
ERBB4ERBB4 0.707 -0.038 1 0.700
ZAP70ZAP70 0.701 0.012 -1 0.671
FESFES 0.696 -0.114 -1 0.659