Motif 531 (n=159)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NHG4 | DDTL | S29 | ochoa | D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein) | May have lyase activity. {ECO:0000305}. |
| B0I1T2 | MYO1G | S842 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| H7C1D1 | None | S268 | ochoa | DUF4657 domain-containing protein | None |
| O00186 | STXBP3 | S512 | ochoa | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
| O14639 | ABLIM1 | S422 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14686 | KMT2D | S1834 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14757 | CHEK1 | S345 | ochoa|psp | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| O14908 | GIPC1 | S225 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
| O15018 | PDZD2 | S944 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15503 | INSIG1 | S125 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43526 | KCNQ2 | S52 | psp | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O43561 | LAT | S224 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60244 | MED14 | S998 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60315 | ZEB2 | S184 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O60381 | HBP1 | S372 | psp | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60784 | TOM1 | S405 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75128 | COBL | S962 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75150 | RNF40 | S601 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75385 | ULK1 | S719 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O94923 | GLCE | S73 | ochoa | D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238, ECO:0000269|PubMed:22528493, ECO:0000269|PubMed:30872481}. |
| O95785 | WIZ | S1335 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P00450 | CP | S499 | ochoa | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). {ECO:0000250|UniProtKB:P13635, ECO:0000269|PubMed:10481051, ECO:0000269|PubMed:14623105, ECO:0000269|PubMed:16150804, ECO:0000269|PubMed:16906150, ECO:0000269|PubMed:4643313, ECO:0000269|PubMed:5912351}. |
| P04198 | MYCN | S145 | ochoa | N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37) | Positively regulates the transcription of MYCNOS in neuroblastoma cells. {ECO:0000269|PubMed:24391509}. |
| P06132 | UROD | S57 | ochoa | Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) | Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824). {ECO:0000269|PubMed:11069625, ECO:0000269|PubMed:11719352, ECO:0000269|PubMed:12071824, ECO:0000269|PubMed:14633982, ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:21668429}. |
| P09661 | SNRPA1 | S178 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P11831 | SRF | S221 | ochoa | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12270 | TPR | S1660 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P22681 | CBL | S705 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P30046 | DDT | S29 | ochoa | D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) | Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). {ECO:0000269|PubMed:8267597, ECO:0000269|PubMed:9480844}. |
| P31645 | SLC6A4 | S48 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P35579 | MYH9 | S628 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35670 | ATP7B | S341 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P38159 | RBMX | S143 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S189 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P41161 | ETV5 | S248 | ochoa | ETS translocation variant 5 (Ets-related protein ERM) | Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}. |
| P43119 | PTGIR | S328 | psp | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| P46013 | MKI67 | S2941 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46734 | MAP2K3 | S28 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P49918 | CDKN1C | S287 | ochoa | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| P51608 | MECP2 | S70 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P53367 | ARFIP1 | S93 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P55201 | BRPF1 | S844 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55317 | FOXA1 | S347 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| Q04637 | EIF4G1 | S1110 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04912 | MST1R | S1031 | ochoa | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269|PubMed:18836480, ECO:0000269|PubMed:7939629, ECO:0000269|PubMed:9764835}. |
| Q07157 | TJP1 | S1399 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08379 | GOLGA2 | S774 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
| Q0VDF9 | HSPA14 | S418 | ochoa | Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) (Heat shock protein family A member 14) | Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity. {ECO:0000269|PubMed:16002468}. |
| Q13263 | TRIM28 | S417 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13480 | GAB1 | S371 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13526 | PIN1 | S32 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13615 | MTMR3 | S909 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q14135 | VGLL4 | S139 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14161 | GIT2 | S500 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14511 | NEDD9 | S333 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14526 | HIC1 | S366 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14596 | NBR1 | S276 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14684 | RRP1B | S458 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14766 | LTBP1 | S501 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14978 | NOLC1 | S397 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15654 | TRIP6 | S161 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q16473 | TNXA | S139 | ochoa | Putative tenascin-XA (TN-XA) | None |
| Q17R91 | DIAPH2 | S196 | psp | Protein diaphanous homolog 2 (Diaphanous-related formin-2) | None |
| Q3KR37 | GRAMD1B | S266 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q52LW3 | ARHGAP29 | S1143 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q562E7 | WDR81 | S1269 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5T1R4 | HIVEP3 | S2006 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T6F2 | UBAP2 | S946 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5T7P8 | SYT6 | S97 | ochoa | Synaptotagmin-6 (Synaptotagmin VI) (SytVI) | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}. |
| Q5TGY3 | AHDC1 | S957 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q68CZ2 | TNS3 | S762 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q69YQ0 | SPECC1L | S921 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6NUJ5 | PWWP2B | S183 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6P1N0 | CC2D1A | S118 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6PCD5 | RFWD3 | S63 | psp | E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) | E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:28691929, ECO:0000269|PubMed:33321094}. |
| Q6ZVM7 | TOM1L2 | S423 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q7Z6I6 | ARHGAP30 | S384 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6I6 | ARHGAP30 | S1064 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86UT8 | CENATAC | S238 | ochoa | Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) | Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype (PubMed:34009673). Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). {ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34009673}. |
| Q86UY5 | FAM83A | S102 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
| Q86VY9 | TMEM200A | S362 | ochoa | Transmembrane protein 200A | None |
| Q8IV36 | HID1 | S598 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IVF2 | AHNAK2 | S38 | ochoa | Protein AHNAK2 | None |
| Q8IVT5 | KSR1 | S257 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IVW6 | ARID3B | S63 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8IWY8 | ZSCAN29 | S137 | ochoa | Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) | May be involved in transcriptional regulation. |
| Q8IZT6 | ASPM | S482 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N163 | CCAR2 | S25 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N4C8 | MINK1 | S754 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NAV2 | C8orf58 | S233 | ochoa | Uncharacterized protein C8orf58 | None |
| Q8NCN4 | RNF169 | S471 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NCN4 | RNF169 | S520 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEZ4 | KMT2C | S3754 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFH8 | REPS2 | S239 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TBA6 | GOLGA5 | S204 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TD26 | CHD6 | S2402 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TEJ3 | SH3RF3 | S438 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
| Q8WUM4 | PDCD6IP | S712 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WXH0 | SYNE2 | S6785 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WZ82 | OVCA2 | S161 | ochoa | Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase domain-containing protein) (Ovarian cancer-associated gene 2 protein) | Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}. |
| Q92619 | ARHGAP45 | S99 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92619 | ARHGAP45 | S582 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q969G5 | CAVIN3 | S165 | ochoa | Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC) | Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}. |
| Q969V6 | MRTFA | S320 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q969V6 | MRTFA | S335 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96A47 | ISL2 | S157 | ochoa | Insulin gene enhancer protein ISL-2 (Islet-2) | Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}. |
| Q96CB8 | INTS12 | S353 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96E39 | RBMXL1 | S143 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S189 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96EV2 | RBM33 | S731 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96JY6 | PDLIM2 | S171 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96KS0 | EGLN2 | S130 | ochoa|psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96PE2 | ARHGEF17 | S324 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PV7 | FAM193B | S730 | ochoa | Protein FAM193B | None |
| Q96RY5 | CRAMP1 | S533 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99956 | DUSP9 | S361 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BT81 | SOX7 | S24 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9BXM7 | PINK1 | S284 | psp | Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) | Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress. It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24898855, PubMed:32047033, PubMed:32484300). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'; activated PRKN then ubiquinates VDAC1 and other OMM proteins to initiate mitophagy (PubMed:14607334, PubMed:15087508, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria through phosphorylation and PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). {ECO:0000250|UniProtKB:Q99MQ3, ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18443288, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20547144, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:24898855, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:32484300}. |
| Q9C0C2 | TNKS1BP1 | S1418 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0E8 | LNPK | S217 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
| Q9GZY8 | MFF | S105 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H175 | CSRNP2 | S504 | ochoa | Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. {ECO:0000250}. |
| Q9H3T3 | SEMA6B | S783 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H4I2 | ZHX3 | S899 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H6K5 | PRR36 | S243 | ochoa | Proline-rich protein 36 | None |
| Q9H6R7 | WDCP | S686 | ochoa|psp | WD repeat and coiled-coil-containing protein | None |
| Q9H7P9 | PLEKHG2 | S1253 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H972 | C14orf93 | S166 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9HCM3 | KIAA1549 | S1644 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9NX70 | MED29 | S137 | ochoa | Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15555573}. |
| Q9NYV4 | CDK12 | S1236 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZ71 | RTEL1 | S882 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9P206 | NHSL3 | S948 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P266 | JCAD | S694 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UGY1 | NOL12 | S139 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q9UGY1 | NOL12 | S140 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q9UHG2 | PCSK1N | S44 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
| Q9UKW4 | VAV3 | S604 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9UL51 | HCN2 | S80 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULQ1 | TPCN1 | S795 | ochoa | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}. |
| Q9UPT6 | MAPK8IP3 | S207 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UPY8 | MAPRE3 | S176 | ochoa|psp | Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). {ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}. |
| Q9Y2K7 | KDM2A | S390 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2U8 | LEMD3 | S117 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W1 | THRAP3 | S219 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4F5 | CEP170B | S868 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y572 | RIPK3 | S241 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y5W9 | SNX11 | S246 | ochoa | Sorting nexin-11 | Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes (PubMed:23615901). Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation (PubMed:26818531). {ECO:0000269|PubMed:23615901, ECO:0000269|PubMed:26818531}. |
| Q9Y6D5 | ARFGEF2 | S1534 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| V9GYY5 | None | S132 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
| V9GYY5 | None | S133 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
| P23588 | EIF4B | S122 | Sugiyama | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| Q96RT7 | TUBGCP6 | S1437 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P08174 | CD55 | S68 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q9H4F8 | SMOC1 | S65 | Sugiyama | SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) | Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. {ECO:0000269|PubMed:20359165, ECO:0000269|PubMed:21194678, ECO:0000269|PubMed:21194680}. |
| O14965 | AURKA | S98 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P32929 | CTH | S61 | Sugiyama | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| P62829 | RPL23 | S115 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P78406 | RAE1 | S74 | Sugiyama | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | Acts as a mRNA export factor involved in nucleocytoplasmic transport (PubMed:20498086, PubMed:33849972). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455). {ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:20498086, ECO:0000269|PubMed:33849972}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000216 | 3.666 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.001322 | 2.879 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.001891 | 2.723 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.001491 | 2.826 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000821 | 3.086 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.001958 | 2.708 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.002556 | 2.592 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003316 | 2.479 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003316 | 2.479 |
| R-HSA-429947 | Deadenylation of mRNA | 0.004059 | 2.392 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.005110 | 2.292 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.008461 | 2.073 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.008798 | 2.056 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.008798 | 2.056 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.009746 | 2.011 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.012556 | 1.901 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.012556 | 1.901 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.012556 | 1.901 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.012556 | 1.901 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.013307 | 1.876 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.041116 | 1.386 |
| R-HSA-5619049 | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | 0.041116 | 1.386 |
| R-HSA-8865999 | MET activates PTPN11 | 0.051129 | 1.291 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.051129 | 1.291 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.051129 | 1.291 |
| R-HSA-1296061 | HCN channels | 0.061039 | 1.214 |
| R-HSA-5619060 | Defective CP causes aceruloplasminemia (ACERULOP) | 0.061039 | 1.214 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.070846 | 1.150 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.080551 | 1.094 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.099659 | 1.001 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.109065 | 0.962 |
| R-HSA-8875656 | MET receptor recycling | 0.109065 | 0.962 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.127584 | 0.894 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.045066 | 1.346 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.163483 | 0.787 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.055525 | 1.256 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.058260 | 1.235 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.058260 | 1.235 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.063868 | 1.195 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.063868 | 1.195 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.066738 | 1.176 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.072603 | 1.139 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.084803 | 1.072 |
| R-HSA-180292 | GAB1 signalosome | 0.214595 | 0.668 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.087944 | 1.056 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.222807 | 0.652 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.222807 | 0.652 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.222807 | 0.652 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.230933 | 0.637 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.254809 | 0.594 |
| R-HSA-72649 | Translation initiation complex formation | 0.138628 | 0.858 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.277947 | 0.556 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.277947 | 0.556 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.145796 | 0.836 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.178898 | 0.747 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.133015 | 0.876 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.286365 | 0.543 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.317204 | 0.499 |
| R-HSA-182971 | EGFR downregulation | 0.322103 | 0.492 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.021765 | 1.662 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.243793 | 0.613 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.163483 | 0.787 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.153040 | 0.815 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.081697 | 1.088 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.182906 | 0.738 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.182906 | 0.738 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.063868 | 1.195 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.182906 | 0.738 |
| R-HSA-191650 | Regulation of gap junction activity | 0.061039 | 1.214 |
| R-HSA-8852405 | Signaling by MST1 | 0.080551 | 1.094 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.209177 | 0.679 |
| R-HSA-2424491 | DAP12 signaling | 0.055525 | 1.256 |
| R-HSA-177929 | Signaling by EGFR | 0.030482 | 1.516 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.075412 | 1.123 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.133015 | 0.876 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.180877 | 0.743 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.157337 | 0.803 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.157337 | 0.803 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.061039 | 1.214 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.246933 | 0.607 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.300371 | 0.522 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.343939 | 0.464 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.343939 | 0.464 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.014503 | 1.839 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.154648 | 0.811 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.032019 | 1.495 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.103649 | 0.984 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 0.030997 | 1.509 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.051129 | 1.291 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.061039 | 1.214 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.099659 | 1.001 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.099659 | 1.001 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.109065 | 0.962 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.154648 | 0.811 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.163483 | 0.787 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.163483 | 0.787 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.172226 | 0.764 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.180877 | 0.743 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.078628 | 1.104 |
| R-HSA-8875878 | MET promotes cell motility | 0.081697 | 1.088 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.107476 | 0.969 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.322103 | 0.492 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.343163 | 0.464 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.309517 | 0.509 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.270469 | 0.568 |
| R-HSA-5218859 | Regulated Necrosis | 0.190178 | 0.721 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.099659 | 1.001 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.206297 | 0.686 |
| R-HSA-3295583 | TRP channels | 0.285500 | 0.544 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.230933 | 0.637 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.127584 | 0.894 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.066738 | 1.176 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.034196 | 1.466 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.246933 | 0.607 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.300371 | 0.522 |
| R-HSA-6806834 | Signaling by MET | 0.066290 | 1.179 |
| R-HSA-2172127 | DAP12 interactions | 0.104144 | 0.982 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.190178 | 0.721 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.063868 | 1.195 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.300371 | 0.522 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.307691 | 0.512 |
| R-HSA-5205647 | Mitophagy | 0.069650 | 1.157 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.061039 | 1.214 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.099659 | 1.001 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.163483 | 0.787 |
| R-HSA-8963901 | Chylomicron remodeling | 0.163483 | 0.787 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.180877 | 0.743 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.214595 | 0.668 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.222807 | 0.652 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.156688 | 0.805 |
| R-HSA-191859 | snRNP Assembly | 0.156688 | 0.805 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.164033 | 0.785 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.314934 | 0.502 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.336216 | 0.473 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.336216 | 0.473 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.075596 | 1.122 |
| R-HSA-9664873 | Pexophagy | 0.127584 | 0.894 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.031695 | 1.499 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.307691 | 0.512 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.314934 | 0.502 |
| R-HSA-9843745 | Adipogenesis | 0.201423 | 0.696 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.322103 | 0.492 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.094328 | 1.025 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.100842 | 0.996 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.030482 | 1.516 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.127584 | 0.894 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.069650 | 1.157 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.214595 | 0.668 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.273296 | 0.563 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.107476 | 0.969 |
| R-HSA-3371556 | Cellular response to heat stress | 0.054873 | 1.261 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.180877 | 0.743 |
| R-HSA-190236 | Signaling by FGFR | 0.107983 | 0.967 |
| R-HSA-68875 | Mitotic Prophase | 0.053684 | 1.270 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.030979 | 1.509 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.030979 | 1.509 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.236069 | 0.627 |
| R-HSA-1632852 | Macroautophagy | 0.086077 | 1.065 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.099659 | 1.001 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.109065 | 0.962 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.035446 | 1.450 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.189439 | 0.723 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.087944 | 1.056 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.087944 | 1.056 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.091119 | 1.040 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.270315 | 0.568 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.292974 | 0.533 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.292974 | 0.533 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.045066 | 1.346 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.022790 | 1.642 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.022790 | 1.642 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.118373 | 0.927 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.182646 | 0.738 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.118373 | 0.927 |
| R-HSA-9663891 | Selective autophagy | 0.083087 | 1.080 |
| R-HSA-9612973 | Autophagy | 0.111895 | 0.951 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.017348 | 1.761 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.163483 | 0.787 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.172226 | 0.764 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.081697 | 1.088 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.214595 | 0.668 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.110837 | 0.955 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.329196 | 0.483 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.205360 | 0.687 |
| R-HSA-1296071 | Potassium Channels | 0.309517 | 0.509 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.206297 | 0.686 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.214595 | 0.668 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.167729 | 0.775 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.307691 | 0.512 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.110837 | 0.955 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.175118 | 0.757 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.084803 | 1.072 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.214595 | 0.668 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.262602 | 0.581 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.307691 | 0.512 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.071723 | 1.144 |
| R-HSA-199991 | Membrane Trafficking | 0.270901 | 0.567 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.142579 | 0.846 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.079208 | 1.101 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.322103 | 0.492 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.022790 | 1.642 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.116858 | 0.932 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.030482 | 1.516 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.078628 | 1.104 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.206297 | 0.686 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.230933 | 0.637 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.246933 | 0.607 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.285500 | 0.544 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.292974 | 0.533 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.167729 | 0.775 |
| R-HSA-74160 | Gene expression (Transcription) | 0.196581 | 0.706 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.091119 | 1.040 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.270885 | 0.567 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.024740 | 1.607 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.072603 | 1.139 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.209177 | 0.679 |
| R-HSA-212436 | Generic Transcription Pathway | 0.101214 | 0.995 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.132115 | 0.879 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.057350 | 1.241 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.163483 | 0.787 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.172226 | 0.764 |
| R-HSA-9839394 | TGFBR3 expression | 0.277947 | 0.556 |
| R-HSA-112311 | Neurotransmitter clearance | 0.314934 | 0.502 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.186407 | 0.730 |
| R-HSA-3214842 | HDMs demethylate histones | 0.277947 | 0.556 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.100842 | 0.996 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.136700 | 0.864 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.136700 | 0.864 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.307691 | 0.512 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.259328 | 0.586 |
| R-HSA-1640170 | Cell Cycle | 0.237364 | 0.625 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.109065 | 0.962 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.314934 | 0.502 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.118834 | 0.925 |
| R-HSA-162582 | Signal Transduction | 0.102852 | 0.988 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.197912 | 0.704 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.336216 | 0.473 |
| R-HSA-70171 | Glycolysis | 0.324871 | 0.488 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.180877 | 0.743 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.254809 | 0.594 |
| R-HSA-1483255 | PI Metabolism | 0.332517 | 0.478 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.277947 | 0.556 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.343163 | 0.464 |
| R-HSA-9733709 | Cardiogenesis | 0.063868 | 1.195 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.127584 | 0.894 |
| R-HSA-201556 | Signaling by ALK | 0.084803 | 1.072 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.254809 | 0.594 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.343163 | 0.464 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.290231 | 0.537 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.277773 | 0.556 |
| R-HSA-165159 | MTOR signalling | 0.097569 | 1.011 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.230933 | 0.637 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.062794 | 1.202 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.340139 | 0.468 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.117638 | 0.929 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.118834 | 0.925 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.054444 | 1.264 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.140900 | 0.851 |
| R-HSA-9758941 | Gastrulation | 0.256390 | 0.591 |
| R-HSA-4839726 | Chromatin organization | 0.312876 | 0.505 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.292974 | 0.533 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.100842 | 0.996 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.236869 | 0.625 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.163483 | 0.787 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.313362 | 0.504 |
| R-HSA-1989781 | PPARA activates gene expression | 0.273296 | 0.563 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.149409 | 0.826 |
| R-HSA-5619102 | SLC transporter disorders | 0.307416 | 0.512 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.131541 | 0.881 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.270315 | 0.568 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.270315 | 0.568 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.278959 | 0.554 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.035923 | 1.445 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.292974 | 0.533 |
| R-HSA-9833110 | RSV-host interactions | 0.343939 | 0.464 |
| R-HSA-162587 | HIV Life Cycle | 0.278959 | 0.554 |
| R-HSA-2028269 | Signaling by Hippo | 0.206297 | 0.686 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.270315 | 0.568 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.178898 | 0.747 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.329196 | 0.483 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.321040 | 0.493 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.110176 | 0.958 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.220669 | 0.656 |
| R-HSA-73887 | Death Receptor Signaling | 0.108496 | 0.965 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.267013 | 0.573 |
| R-HSA-168255 | Influenza Infection | 0.344552 | 0.463 |
| R-HSA-2559583 | Cellular Senescence | 0.347406 | 0.459 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.347733 | 0.459 |
| R-HSA-5673000 | RAF activation | 0.350038 | 0.456 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.350038 | 0.456 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.350038 | 0.456 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.350038 | 0.456 |
| R-HSA-211000 | Gene Silencing by RNA | 0.355299 | 0.449 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.356841 | 0.448 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.356841 | 0.448 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.356841 | 0.448 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.356841 | 0.448 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.356841 | 0.448 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.359071 | 0.445 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.363573 | 0.439 |
| R-HSA-8853659 | RET signaling | 0.363573 | 0.439 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.363573 | 0.439 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.363573 | 0.439 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.366590 | 0.436 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.366590 | 0.436 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.370236 | 0.432 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.370236 | 0.432 |
| R-HSA-983712 | Ion channel transport | 0.373027 | 0.428 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.374075 | 0.427 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.374075 | 0.427 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.374075 | 0.427 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.376828 | 0.424 |
| R-HSA-1566948 | Elastic fibre formation | 0.376828 | 0.424 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.381524 | 0.418 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.383353 | 0.416 |
| R-HSA-422475 | Axon guidance | 0.383892 | 0.416 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.383935 | 0.416 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.385235 | 0.414 |
| R-HSA-202433 | Generation of second messenger molecules | 0.389809 | 0.409 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.392628 | 0.406 |
| R-HSA-9609690 | HCMV Early Events | 0.392828 | 0.406 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.396198 | 0.402 |
| R-HSA-9607240 | FLT3 Signaling | 0.396198 | 0.402 |
| R-HSA-70326 | Glucose metabolism | 0.399981 | 0.398 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.402521 | 0.395 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.402521 | 0.395 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.402521 | 0.395 |
| R-HSA-189451 | Heme biosynthesis | 0.402521 | 0.395 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.402521 | 0.395 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.402521 | 0.395 |
| R-HSA-5693538 | Homology Directed Repair | 0.403642 | 0.394 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.408778 | 0.389 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.408778 | 0.389 |
| R-HSA-8854214 | TBC/RABGAPs | 0.414969 | 0.382 |
| R-HSA-68886 | M Phase | 0.416455 | 0.380 |
| R-HSA-913531 | Interferon Signaling | 0.418519 | 0.378 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.419928 | 0.377 |
| R-HSA-5357801 | Programmed Cell Death | 0.420831 | 0.376 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.421097 | 0.376 |
| R-HSA-69236 | G1 Phase | 0.421097 | 0.376 |
| R-HSA-373752 | Netrin-1 signaling | 0.421097 | 0.376 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.425381 | 0.371 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.427160 | 0.369 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.427160 | 0.369 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.427160 | 0.369 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.433160 | 0.363 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.433160 | 0.363 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.433160 | 0.363 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.433160 | 0.363 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.433160 | 0.363 |
| R-HSA-75153 | Apoptotic execution phase | 0.433160 | 0.363 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.439098 | 0.357 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.444974 | 0.352 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.444974 | 0.352 |
| R-HSA-425410 | Metal ion SLC transporters | 0.444974 | 0.352 |
| R-HSA-9675108 | Nervous system development | 0.447289 | 0.349 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.450789 | 0.346 |
| R-HSA-109704 | PI3K Cascade | 0.456543 | 0.341 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.456543 | 0.341 |
| R-HSA-9748787 | Azathioprine ADME | 0.456543 | 0.341 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.462238 | 0.335 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.467873 | 0.330 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.467873 | 0.330 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.467873 | 0.330 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.473449 | 0.325 |
| R-HSA-1221632 | Meiotic synapsis | 0.473449 | 0.325 |
| R-HSA-162906 | HIV Infection | 0.480774 | 0.318 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.481243 | 0.318 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.483433 | 0.316 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.486105 | 0.313 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.489832 | 0.310 |
| R-HSA-75893 | TNF signaling | 0.489832 | 0.310 |
| R-HSA-9664407 | Parasite infection | 0.491347 | 0.309 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.491347 | 0.309 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.491347 | 0.309 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.494687 | 0.306 |
| R-HSA-112399 | IRS-mediated signalling | 0.495179 | 0.305 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.500471 | 0.301 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.501326 | 0.300 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.504625 | 0.297 |
| R-HSA-180786 | Extension of Telomeres | 0.505707 | 0.296 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.505707 | 0.296 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.506768 | 0.295 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.510890 | 0.292 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.510890 | 0.292 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.516018 | 0.287 |
| R-HSA-450294 | MAP kinase activation | 0.516018 | 0.287 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.516018 | 0.287 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.517679 | 0.286 |
| R-HSA-166520 | Signaling by NTRKs | 0.520907 | 0.283 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.520907 | 0.283 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.526114 | 0.279 |
| R-HSA-8848021 | Signaling by PTK6 | 0.526114 | 0.279 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.526114 | 0.279 |
| R-HSA-373755 | Semaphorin interactions | 0.526114 | 0.279 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.531083 | 0.275 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.531083 | 0.275 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.531083 | 0.275 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.532656 | 0.274 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.533674 | 0.273 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.536001 | 0.271 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.536001 | 0.271 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.536830 | 0.270 |
| R-HSA-9609646 | HCMV Infection | 0.540189 | 0.267 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.540867 | 0.267 |
| R-HSA-8953854 | Metabolism of RNA | 0.545752 | 0.263 |
| R-HSA-9610379 | HCMV Late Events | 0.549306 | 0.260 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.550448 | 0.259 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.559830 | 0.252 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.559830 | 0.252 |
| R-HSA-448424 | Interleukin-17 signaling | 0.559830 | 0.252 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.559830 | 0.252 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.559830 | 0.252 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.564448 | 0.248 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.564448 | 0.248 |
| R-HSA-189445 | Metabolism of porphyrins | 0.564448 | 0.248 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.564448 | 0.248 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.569017 | 0.245 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.569017 | 0.245 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.569017 | 0.245 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.570571 | 0.244 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.573539 | 0.241 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.578014 | 0.238 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.578014 | 0.238 |
| R-HSA-380287 | Centrosome maturation | 0.582442 | 0.235 |
| R-HSA-8852135 | Protein ubiquitination | 0.582442 | 0.235 |
| R-HSA-917937 | Iron uptake and transport | 0.582442 | 0.235 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.591106 | 0.228 |
| R-HSA-72306 | tRNA processing | 0.591106 | 0.228 |
| R-HSA-1266738 | Developmental Biology | 0.596038 | 0.225 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.596838 | 0.224 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.597870 | 0.223 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.599682 | 0.222 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.599682 | 0.222 |
| R-HSA-9659379 | Sensory processing of sound | 0.599698 | 0.222 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.599698 | 0.222 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.602511 | 0.220 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.603900 | 0.219 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.608058 | 0.216 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.608058 | 0.216 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.620273 | 0.207 |
| R-HSA-1500620 | Meiosis | 0.624260 | 0.205 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.627294 | 0.203 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.628206 | 0.202 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.631458 | 0.200 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.632110 | 0.199 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.632110 | 0.199 |
| R-HSA-69275 | G2/M Transition | 0.635287 | 0.197 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.635974 | 0.197 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.639797 | 0.194 |
| R-HSA-156902 | Peptide chain elongation | 0.639797 | 0.194 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.640540 | 0.193 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.640540 | 0.193 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.646460 | 0.189 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.647324 | 0.189 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.648310 | 0.188 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.651029 | 0.186 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.655947 | 0.183 |
| R-HSA-2262752 | Cellular responses to stress | 0.656055 | 0.183 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.658323 | 0.182 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.658323 | 0.182 |
| R-HSA-391251 | Protein folding | 0.658323 | 0.182 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.658323 | 0.182 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.660965 | 0.180 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.665465 | 0.177 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.668980 | 0.175 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.668980 | 0.175 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.670825 | 0.173 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.672459 | 0.172 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.672459 | 0.172 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.672459 | 0.172 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.675669 | 0.170 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.678069 | 0.169 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.678069 | 0.169 |
| R-HSA-157579 | Telomere Maintenance | 0.679307 | 0.168 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.682678 | 0.166 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.682678 | 0.166 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.682678 | 0.166 |
| R-HSA-72172 | mRNA Splicing | 0.682826 | 0.166 |
| R-HSA-3214847 | HATs acetylate histones | 0.686013 | 0.164 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.692580 | 0.160 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.692580 | 0.160 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.695812 | 0.158 |
| R-HSA-192823 | Viral mRNA Translation | 0.699010 | 0.156 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.702175 | 0.154 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.705306 | 0.152 |
| R-HSA-418346 | Platelet homeostasis | 0.711472 | 0.148 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.711472 | 0.148 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.714506 | 0.146 |
| R-HSA-418990 | Adherens junctions interactions | 0.714539 | 0.146 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.717509 | 0.144 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.717509 | 0.144 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.720480 | 0.142 |
| R-HSA-202403 | TCR signaling | 0.723421 | 0.141 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.732058 | 0.135 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.740428 | 0.131 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.742702 | 0.129 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.743159 | 0.129 |
| R-HSA-72312 | rRNA processing | 0.743567 | 0.129 |
| R-HSA-373760 | L1CAM interactions | 0.745862 | 0.127 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.746015 | 0.127 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.748537 | 0.126 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.751184 | 0.124 |
| R-HSA-8939211 | ESR-mediated signaling | 0.753308 | 0.123 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.753803 | 0.123 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.753803 | 0.123 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.753803 | 0.123 |
| R-HSA-73886 | Chromosome Maintenance | 0.758959 | 0.120 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.758959 | 0.120 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.761497 | 0.118 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.761497 | 0.118 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.764008 | 0.117 |
| R-HSA-977606 | Regulation of Complement cascade | 0.768952 | 0.114 |
| R-HSA-194138 | Signaling by VEGF | 0.771385 | 0.113 |
| R-HSA-69481 | G2/M Checkpoints | 0.776175 | 0.110 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.778533 | 0.109 |
| R-HSA-421270 | Cell-cell junction organization | 0.778913 | 0.109 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.783174 | 0.106 |
| R-HSA-1474165 | Reproduction | 0.785458 | 0.105 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.787482 | 0.104 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.787687 | 0.104 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.792168 | 0.101 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.800791 | 0.096 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.804969 | 0.094 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.808034 | 0.093 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.818212 | 0.087 |
| R-HSA-166658 | Complement cascade | 0.820825 | 0.086 |
| R-HSA-446728 | Cell junction organization | 0.821816 | 0.085 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.822715 | 0.085 |
| R-HSA-2187338 | Visual phototransduction | 0.824584 | 0.084 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.826094 | 0.083 |
| R-HSA-9658195 | Leishmania infection | 0.826094 | 0.083 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.831870 | 0.080 |
| R-HSA-9711097 | Cellular response to starvation | 0.843903 | 0.074 |
| R-HSA-1483257 | Phospholipid metabolism | 0.844868 | 0.073 |
| R-HSA-195721 | Signaling by WNT | 0.848645 | 0.071 |
| R-HSA-109581 | Apoptosis | 0.850390 | 0.070 |
| R-HSA-72766 | Translation | 0.853770 | 0.069 |
| R-HSA-9679506 | SARS-CoV Infections | 0.857576 | 0.067 |
| R-HSA-9824446 | Viral Infection Pathways | 0.857649 | 0.067 |
| R-HSA-418555 | G alpha (s) signalling events | 0.865460 | 0.063 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.868288 | 0.061 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.868288 | 0.061 |
| R-HSA-1500931 | Cell-Cell communication | 0.869612 | 0.061 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.871057 | 0.060 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.878740 | 0.056 |
| R-HSA-6798695 | Neutrophil degranulation | 0.880496 | 0.055 |
| R-HSA-112316 | Neuronal System | 0.889757 | 0.051 |
| R-HSA-68877 | Mitotic Prometaphase | 0.893510 | 0.049 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.893510 | 0.049 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.901151 | 0.045 |
| R-HSA-1643685 | Disease | 0.906147 | 0.043 |
| R-HSA-73894 | DNA Repair | 0.910157 | 0.041 |
| R-HSA-449147 | Signaling by Interleukins | 0.910508 | 0.041 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.912443 | 0.040 |
| R-HSA-68882 | Mitotic Anaphase | 0.917515 | 0.037 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.918389 | 0.037 |
| R-HSA-5663205 | Infectious disease | 0.919173 | 0.037 |
| R-HSA-9748784 | Drug ADME | 0.919253 | 0.037 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.935390 | 0.029 |
| R-HSA-597592 | Post-translational protein modification | 0.945237 | 0.024 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.947296 | 0.024 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.948174 | 0.023 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.950037 | 0.022 |
| R-HSA-168249 | Innate Immune System | 0.950208 | 0.022 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.952636 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 0.955055 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 0.956096 | 0.019 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.959220 | 0.018 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.964516 | 0.016 |
| R-HSA-388396 | GPCR downstream signalling | 0.969472 | 0.013 |
| R-HSA-109582 | Hemostasis | 0.971701 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.973712 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 0.973993 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 0.975874 | 0.011 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.978561 | 0.009 |
| R-HSA-168256 | Immune System | 0.980940 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.983074 | 0.007 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.986350 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.987875 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.988191 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 0.988792 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.991482 | 0.004 |
| R-HSA-1280218 | Adaptive Immune System | 0.996591 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998945 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999984 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.871 | 0.187 | 2 | 0.816 |
CLK3 |
0.870 | 0.293 | 1 | 0.818 |
CDC7 |
0.863 | 0.128 | 1 | 0.843 |
PIM3 |
0.862 | 0.196 | -3 | 0.856 |
PRKD1 |
0.859 | 0.228 | -3 | 0.858 |
MOS |
0.858 | 0.145 | 1 | 0.855 |
SRPK1 |
0.856 | 0.223 | -3 | 0.799 |
NLK |
0.856 | 0.146 | 1 | 0.846 |
RSK2 |
0.855 | 0.209 | -3 | 0.802 |
HIPK4 |
0.854 | 0.218 | 1 | 0.798 |
NDR2 |
0.854 | 0.105 | -3 | 0.846 |
MTOR |
0.854 | -0.007 | 1 | 0.799 |
PRKD2 |
0.853 | 0.202 | -3 | 0.788 |
IKKB |
0.853 | -0.022 | -2 | 0.720 |
RAF1 |
0.853 | 0.023 | 1 | 0.843 |
DSTYK |
0.852 | 0.044 | 2 | 0.827 |
CDKL1 |
0.852 | 0.148 | -3 | 0.842 |
CAMK1B |
0.852 | 0.123 | -3 | 0.870 |
PRPK |
0.852 | -0.072 | -1 | 0.874 |
AURC |
0.851 | 0.234 | -2 | 0.741 |
GCN2 |
0.851 | -0.092 | 2 | 0.716 |
SKMLCK |
0.850 | 0.198 | -2 | 0.875 |
CDKL5 |
0.849 | 0.160 | -3 | 0.838 |
ERK5 |
0.849 | 0.112 | 1 | 0.839 |
MST4 |
0.849 | 0.093 | 2 | 0.799 |
CLK2 |
0.849 | 0.301 | -3 | 0.783 |
NEK6 |
0.849 | 0.046 | -2 | 0.802 |
TBK1 |
0.848 | -0.035 | 1 | 0.750 |
PKN3 |
0.848 | 0.092 | -3 | 0.855 |
P90RSK |
0.848 | 0.155 | -3 | 0.820 |
RSK3 |
0.848 | 0.160 | -3 | 0.805 |
PIM1 |
0.848 | 0.177 | -3 | 0.798 |
BMPR2 |
0.847 | -0.005 | -2 | 0.846 |
BMPR1B |
0.847 | 0.251 | 1 | 0.838 |
MAPKAPK2 |
0.847 | 0.182 | -3 | 0.752 |
DYRK2 |
0.847 | 0.207 | 1 | 0.739 |
IKKE |
0.847 | -0.037 | 1 | 0.750 |
NDR1 |
0.846 | 0.080 | -3 | 0.841 |
TGFBR2 |
0.846 | 0.039 | -2 | 0.754 |
ULK2 |
0.846 | -0.075 | 2 | 0.691 |
MAPKAPK3 |
0.846 | 0.146 | -3 | 0.796 |
ICK |
0.846 | 0.164 | -3 | 0.869 |
NUAK2 |
0.846 | 0.091 | -3 | 0.842 |
CAMLCK |
0.846 | 0.154 | -2 | 0.871 |
ATR |
0.845 | -0.007 | 1 | 0.784 |
PKN2 |
0.845 | 0.103 | -3 | 0.837 |
PDHK4 |
0.845 | -0.221 | 1 | 0.844 |
DAPK2 |
0.844 | 0.162 | -3 | 0.879 |
SRPK2 |
0.844 | 0.181 | -3 | 0.728 |
CAMK2D |
0.844 | 0.082 | -3 | 0.853 |
KIS |
0.844 | 0.113 | 1 | 0.721 |
IKKA |
0.843 | 0.015 | -2 | 0.702 |
CAMK2G |
0.843 | -0.087 | 2 | 0.755 |
CLK4 |
0.843 | 0.226 | -3 | 0.792 |
PKACG |
0.843 | 0.140 | -2 | 0.800 |
NIK |
0.843 | 0.058 | -3 | 0.877 |
PKCD |
0.842 | 0.123 | 2 | 0.693 |
P70S6KB |
0.842 | 0.129 | -3 | 0.813 |
WNK1 |
0.841 | 0.011 | -2 | 0.871 |
CLK1 |
0.841 | 0.221 | -3 | 0.764 |
NEK7 |
0.841 | -0.091 | -3 | 0.842 |
LATS2 |
0.841 | 0.059 | -5 | 0.791 |
PDHK1 |
0.840 | -0.171 | 1 | 0.826 |
PKACB |
0.840 | 0.217 | -2 | 0.755 |
CHAK2 |
0.839 | -0.000 | -1 | 0.839 |
TGFBR1 |
0.839 | 0.153 | -2 | 0.776 |
AMPKA1 |
0.839 | 0.059 | -3 | 0.852 |
SRPK3 |
0.839 | 0.155 | -3 | 0.773 |
GRK5 |
0.839 | -0.094 | -3 | 0.840 |
MLK1 |
0.839 | -0.073 | 2 | 0.727 |
MARK4 |
0.838 | 0.011 | 4 | 0.820 |
CAMK2B |
0.838 | 0.109 | 2 | 0.742 |
GRK1 |
0.838 | 0.035 | -2 | 0.737 |
RIPK3 |
0.838 | -0.059 | 3 | 0.675 |
CAMK2A |
0.838 | 0.116 | 2 | 0.756 |
HIPK2 |
0.838 | 0.211 | 1 | 0.660 |
AURA |
0.838 | 0.193 | -2 | 0.710 |
RSK4 |
0.837 | 0.177 | -3 | 0.776 |
CDK8 |
0.837 | 0.079 | 1 | 0.691 |
HUNK |
0.836 | -0.082 | 2 | 0.748 |
GRK6 |
0.836 | 0.008 | 1 | 0.840 |
MSK2 |
0.836 | 0.120 | -3 | 0.784 |
PRKD3 |
0.836 | 0.138 | -3 | 0.771 |
MSK1 |
0.836 | 0.179 | -3 | 0.782 |
PAK6 |
0.836 | 0.179 | -2 | 0.770 |
TSSK2 |
0.836 | 0.063 | -5 | 0.884 |
AKT2 |
0.836 | 0.206 | -3 | 0.720 |
MNK2 |
0.835 | 0.119 | -2 | 0.848 |
TSSK1 |
0.835 | 0.086 | -3 | 0.874 |
FAM20C |
0.835 | 0.072 | 2 | 0.603 |
AURB |
0.835 | 0.172 | -2 | 0.737 |
JNK2 |
0.835 | 0.163 | 1 | 0.665 |
ULK1 |
0.834 | -0.149 | -3 | 0.825 |
CDK19 |
0.834 | 0.094 | 1 | 0.658 |
NEK9 |
0.834 | -0.074 | 2 | 0.749 |
PAK1 |
0.834 | 0.106 | -2 | 0.828 |
ALK4 |
0.834 | 0.095 | -2 | 0.802 |
HIPK1 |
0.834 | 0.202 | 1 | 0.752 |
PKCA |
0.834 | 0.103 | 2 | 0.630 |
LATS1 |
0.834 | 0.118 | -3 | 0.860 |
PKCB |
0.834 | 0.084 | 2 | 0.648 |
CDK5 |
0.834 | 0.134 | 1 | 0.719 |
AMPKA2 |
0.833 | 0.062 | -3 | 0.822 |
PKG2 |
0.833 | 0.174 | -2 | 0.754 |
BCKDK |
0.833 | -0.148 | -1 | 0.801 |
CDK1 |
0.833 | 0.122 | 1 | 0.676 |
MLK2 |
0.833 | -0.037 | 2 | 0.737 |
MLK3 |
0.833 | 0.012 | 2 | 0.654 |
CDK7 |
0.833 | 0.078 | 1 | 0.705 |
PAK3 |
0.832 | 0.071 | -2 | 0.830 |
PKCG |
0.832 | 0.068 | 2 | 0.646 |
DYRK4 |
0.832 | 0.190 | 1 | 0.668 |
PRKX |
0.832 | 0.203 | -3 | 0.688 |
P38A |
0.831 | 0.128 | 1 | 0.747 |
JNK3 |
0.831 | 0.129 | 1 | 0.689 |
CDK18 |
0.831 | 0.123 | 1 | 0.642 |
MASTL |
0.830 | -0.220 | -2 | 0.785 |
CDK13 |
0.830 | 0.088 | 1 | 0.683 |
DLK |
0.830 | -0.126 | 1 | 0.824 |
PKR |
0.830 | 0.070 | 1 | 0.816 |
NIM1 |
0.830 | -0.044 | 3 | 0.722 |
IRE1 |
0.830 | -0.033 | 1 | 0.771 |
ANKRD3 |
0.829 | -0.111 | 1 | 0.844 |
PLK1 |
0.829 | -0.014 | -2 | 0.765 |
GRK7 |
0.828 | 0.065 | 1 | 0.773 |
PHKG1 |
0.828 | 0.017 | -3 | 0.831 |
P38B |
0.828 | 0.134 | 1 | 0.683 |
CAMK4 |
0.828 | -0.010 | -3 | 0.814 |
MYLK4 |
0.828 | 0.128 | -2 | 0.822 |
MELK |
0.828 | 0.037 | -3 | 0.815 |
ATM |
0.828 | -0.051 | 1 | 0.720 |
WNK3 |
0.828 | -0.238 | 1 | 0.795 |
QSK |
0.828 | 0.041 | 4 | 0.812 |
SGK3 |
0.827 | 0.148 | -3 | 0.780 |
ACVR2B |
0.827 | 0.087 | -2 | 0.749 |
HIPK3 |
0.827 | 0.172 | 1 | 0.757 |
DYRK3 |
0.827 | 0.211 | 1 | 0.755 |
PIM2 |
0.827 | 0.150 | -3 | 0.773 |
ALK2 |
0.827 | 0.099 | -2 | 0.771 |
NEK2 |
0.827 | -0.007 | 2 | 0.723 |
PRP4 |
0.827 | 0.187 | -3 | 0.839 |
MNK1 |
0.827 | 0.080 | -2 | 0.855 |
DYRK1A |
0.826 | 0.155 | 1 | 0.755 |
ACVR2A |
0.826 | 0.070 | -2 | 0.740 |
PKCZ |
0.826 | 0.033 | 2 | 0.685 |
RIPK1 |
0.826 | -0.163 | 1 | 0.804 |
BMPR1A |
0.826 | 0.170 | 1 | 0.806 |
IRE2 |
0.826 | -0.019 | 2 | 0.646 |
YSK4 |
0.826 | -0.057 | 1 | 0.780 |
P38G |
0.825 | 0.121 | 1 | 0.595 |
NUAK1 |
0.825 | 0.011 | -3 | 0.798 |
PKCH |
0.825 | 0.042 | 2 | 0.617 |
DYRK1B |
0.825 | 0.156 | 1 | 0.700 |
ERK1 |
0.825 | 0.098 | 1 | 0.675 |
CDK12 |
0.825 | 0.095 | 1 | 0.660 |
GRK4 |
0.824 | -0.164 | -2 | 0.757 |
MLK4 |
0.824 | -0.043 | 2 | 0.633 |
CDK3 |
0.823 | 0.127 | 1 | 0.614 |
CDK9 |
0.823 | 0.069 | 1 | 0.691 |
DRAK1 |
0.823 | 0.053 | 1 | 0.801 |
DNAPK |
0.823 | -0.008 | 1 | 0.676 |
PKACA |
0.822 | 0.186 | -2 | 0.716 |
PAK2 |
0.822 | 0.045 | -2 | 0.812 |
TTBK2 |
0.822 | -0.200 | 2 | 0.633 |
MEK1 |
0.822 | -0.138 | 2 | 0.764 |
VRK2 |
0.822 | -0.120 | 1 | 0.850 |
SIK |
0.822 | 0.021 | -3 | 0.771 |
BRSK1 |
0.821 | 0.003 | -3 | 0.808 |
MARK3 |
0.821 | 0.029 | 4 | 0.773 |
TLK2 |
0.821 | -0.016 | 1 | 0.762 |
DCAMKL1 |
0.821 | 0.075 | -3 | 0.792 |
CDK17 |
0.821 | 0.087 | 1 | 0.594 |
CDK2 |
0.821 | 0.045 | 1 | 0.746 |
CHK1 |
0.821 | 0.013 | -3 | 0.819 |
QIK |
0.821 | -0.085 | -3 | 0.834 |
CDK14 |
0.821 | 0.125 | 1 | 0.689 |
MST3 |
0.820 | 0.079 | 2 | 0.776 |
AKT1 |
0.820 | 0.174 | -3 | 0.730 |
MAPKAPK5 |
0.820 | 0.006 | -3 | 0.769 |
PLK3 |
0.820 | -0.069 | 2 | 0.720 |
CHAK1 |
0.819 | -0.103 | 2 | 0.693 |
SMG1 |
0.819 | -0.076 | 1 | 0.726 |
P38D |
0.819 | 0.134 | 1 | 0.596 |
CDK10 |
0.819 | 0.140 | 1 | 0.676 |
PINK1 |
0.818 | -0.051 | 1 | 0.810 |
ERK2 |
0.818 | 0.049 | 1 | 0.711 |
MARK2 |
0.818 | 0.001 | 4 | 0.732 |
PKCT |
0.817 | 0.069 | 2 | 0.627 |
SMMLCK |
0.816 | 0.104 | -3 | 0.837 |
CAMK1G |
0.816 | 0.040 | -3 | 0.784 |
MAK |
0.816 | 0.215 | -2 | 0.743 |
CDK16 |
0.816 | 0.113 | 1 | 0.607 |
BRSK2 |
0.815 | -0.072 | -3 | 0.820 |
PASK |
0.815 | 0.081 | -3 | 0.864 |
BRAF |
0.814 | -0.058 | -4 | 0.806 |
P70S6K |
0.814 | 0.081 | -3 | 0.739 |
TAO3 |
0.814 | 0.016 | 1 | 0.794 |
PAK5 |
0.814 | 0.118 | -2 | 0.710 |
PERK |
0.814 | -0.096 | -2 | 0.774 |
AKT3 |
0.814 | 0.197 | -3 | 0.667 |
GRK2 |
0.814 | -0.046 | -2 | 0.661 |
NEK5 |
0.813 | -0.031 | 1 | 0.808 |
SNRK |
0.813 | -0.146 | 2 | 0.586 |
MPSK1 |
0.813 | 0.078 | 1 | 0.777 |
MARK1 |
0.812 | -0.034 | 4 | 0.785 |
HRI |
0.812 | -0.147 | -2 | 0.797 |
PKCI |
0.812 | 0.049 | 2 | 0.648 |
LKB1 |
0.812 | 0.085 | -3 | 0.851 |
MEKK1 |
0.812 | -0.126 | 1 | 0.794 |
GAK |
0.811 | 0.114 | 1 | 0.846 |
PAK4 |
0.811 | 0.125 | -2 | 0.722 |
PKCE |
0.811 | 0.105 | 2 | 0.630 |
MEK5 |
0.811 | -0.199 | 2 | 0.741 |
GSK3A |
0.811 | 0.049 | 4 | 0.431 |
ZAK |
0.811 | -0.130 | 1 | 0.773 |
PHKG2 |
0.811 | -0.007 | -3 | 0.791 |
PLK4 |
0.810 | -0.135 | 2 | 0.547 |
TLK1 |
0.810 | -0.094 | -2 | 0.772 |
MEKK2 |
0.810 | -0.083 | 2 | 0.711 |
WNK4 |
0.809 | -0.106 | -2 | 0.844 |
DCAMKL2 |
0.809 | -0.008 | -3 | 0.810 |
SSTK |
0.809 | 0.006 | 4 | 0.804 |
DAPK3 |
0.809 | 0.137 | -3 | 0.811 |
GCK |
0.809 | 0.089 | 1 | 0.825 |
TNIK |
0.808 | 0.122 | 3 | 0.845 |
IRAK4 |
0.808 | -0.089 | 1 | 0.776 |
ERK7 |
0.808 | 0.021 | 2 | 0.463 |
CAMK1D |
0.808 | 0.078 | -3 | 0.708 |
CK2A2 |
0.808 | 0.096 | 1 | 0.722 |
MOK |
0.807 | 0.181 | 1 | 0.776 |
MEKK3 |
0.807 | -0.185 | 1 | 0.809 |
CAMKK1 |
0.807 | -0.064 | -2 | 0.737 |
SGK1 |
0.807 | 0.166 | -3 | 0.650 |
GSK3B |
0.807 | -0.007 | 4 | 0.427 |
JNK1 |
0.805 | 0.074 | 1 | 0.647 |
CAMKK2 |
0.805 | -0.023 | -2 | 0.743 |
PKN1 |
0.805 | 0.071 | -3 | 0.749 |
CDK6 |
0.805 | 0.095 | 1 | 0.667 |
TAO2 |
0.805 | -0.043 | 2 | 0.762 |
HPK1 |
0.805 | 0.075 | 1 | 0.820 |
DAPK1 |
0.805 | 0.139 | -3 | 0.799 |
MINK |
0.805 | 0.050 | 1 | 0.801 |
HGK |
0.804 | 0.045 | 3 | 0.836 |
PDK1 |
0.804 | -0.012 | 1 | 0.788 |
CHK2 |
0.804 | 0.106 | -3 | 0.664 |
NEK8 |
0.804 | -0.099 | 2 | 0.726 |
MEKK6 |
0.804 | -0.004 | 1 | 0.795 |
NEK11 |
0.803 | -0.141 | 1 | 0.804 |
CDK4 |
0.803 | 0.093 | 1 | 0.642 |
MRCKB |
0.803 | 0.146 | -3 | 0.752 |
NEK4 |
0.802 | -0.038 | 1 | 0.786 |
MST2 |
0.802 | -0.032 | 1 | 0.817 |
ROCK2 |
0.802 | 0.153 | -3 | 0.798 |
BUB1 |
0.801 | 0.145 | -5 | 0.810 |
CK1E |
0.801 | -0.090 | -3 | 0.511 |
KHS1 |
0.801 | 0.098 | 1 | 0.796 |
LOK |
0.800 | 0.019 | -2 | 0.782 |
KHS2 |
0.800 | 0.109 | 1 | 0.812 |
TAK1 |
0.800 | -0.022 | 1 | 0.807 |
GRK3 |
0.799 | -0.054 | -2 | 0.612 |
MRCKA |
0.799 | 0.117 | -3 | 0.764 |
EEF2K |
0.799 | -0.001 | 3 | 0.802 |
CK2A1 |
0.798 | 0.081 | 1 | 0.707 |
NEK1 |
0.798 | 0.000 | 1 | 0.788 |
PBK |
0.797 | 0.099 | 1 | 0.771 |
SBK |
0.797 | 0.128 | -3 | 0.607 |
IRAK1 |
0.796 | -0.259 | -1 | 0.756 |
MAP3K15 |
0.796 | -0.092 | 1 | 0.761 |
CK1D |
0.796 | -0.075 | -3 | 0.457 |
CAMK1A |
0.795 | 0.084 | -3 | 0.677 |
DMPK1 |
0.794 | 0.165 | -3 | 0.761 |
TTBK1 |
0.794 | -0.224 | 2 | 0.557 |
CK1G1 |
0.793 | -0.117 | -3 | 0.508 |
VRK1 |
0.793 | -0.096 | 2 | 0.761 |
PLK2 |
0.793 | -0.056 | -3 | 0.782 |
MST1 |
0.793 | -0.064 | 1 | 0.794 |
LRRK2 |
0.793 | -0.132 | 2 | 0.760 |
SLK |
0.792 | -0.055 | -2 | 0.711 |
CK1A2 |
0.792 | -0.083 | -3 | 0.457 |
PKG1 |
0.792 | 0.110 | -2 | 0.683 |
YSK1 |
0.792 | -0.028 | 2 | 0.724 |
ROCK1 |
0.789 | 0.133 | -3 | 0.766 |
PDHK3_TYR |
0.787 | 0.194 | 4 | 0.847 |
NEK3 |
0.787 | -0.069 | 1 | 0.751 |
OSR1 |
0.786 | 0.005 | 2 | 0.712 |
MYO3B |
0.786 | 0.065 | 2 | 0.743 |
CRIK |
0.786 | 0.131 | -3 | 0.732 |
STK33 |
0.785 | -0.165 | 2 | 0.540 |
MEK2 |
0.785 | -0.217 | 2 | 0.725 |
BIKE |
0.783 | 0.086 | 1 | 0.737 |
RIPK2 |
0.780 | -0.290 | 1 | 0.734 |
MAP2K4_TYR |
0.780 | 0.080 | -1 | 0.889 |
TTK |
0.779 | -0.055 | -2 | 0.769 |
TESK1_TYR |
0.779 | 0.027 | 3 | 0.847 |
MYO3A |
0.778 | -0.005 | 1 | 0.784 |
MAP2K6_TYR |
0.778 | 0.068 | -1 | 0.895 |
HASPIN |
0.778 | -0.017 | -1 | 0.687 |
PDHK4_TYR |
0.777 | 0.053 | 2 | 0.827 |
BMPR2_TYR |
0.777 | 0.061 | -1 | 0.879 |
LIMK2_TYR |
0.777 | 0.110 | -3 | 0.888 |
TAO1 |
0.775 | -0.062 | 1 | 0.727 |
EPHA6 |
0.775 | 0.101 | -1 | 0.869 |
PKMYT1_TYR |
0.774 | -0.031 | 3 | 0.808 |
MAP2K7_TYR |
0.773 | -0.137 | 2 | 0.790 |
ASK1 |
0.773 | -0.138 | 1 | 0.747 |
PDHK1_TYR |
0.771 | -0.040 | -1 | 0.901 |
EPHB4 |
0.771 | 0.069 | -1 | 0.849 |
ABL2 |
0.771 | 0.103 | -1 | 0.826 |
RET |
0.770 | -0.015 | 1 | 0.787 |
AAK1 |
0.770 | 0.131 | 1 | 0.643 |
PINK1_TYR |
0.770 | -0.131 | 1 | 0.822 |
TXK |
0.769 | 0.152 | 1 | 0.839 |
YANK3 |
0.768 | -0.105 | 2 | 0.379 |
TYRO3 |
0.766 | -0.042 | 3 | 0.749 |
ROS1 |
0.765 | -0.043 | 3 | 0.716 |
ABL1 |
0.765 | 0.060 | -1 | 0.817 |
ITK |
0.765 | 0.069 | -1 | 0.802 |
FGR |
0.765 | 0.005 | 1 | 0.843 |
LCK |
0.765 | 0.089 | -1 | 0.830 |
LIMK1_TYR |
0.765 | -0.139 | 2 | 0.768 |
ALPHAK3 |
0.765 | -0.119 | -1 | 0.794 |
MST1R |
0.764 | -0.108 | 3 | 0.757 |
CSF1R |
0.763 | -0.066 | 3 | 0.729 |
TYK2 |
0.762 | -0.163 | 1 | 0.784 |
BLK |
0.761 | 0.089 | -1 | 0.834 |
YES1 |
0.761 | -0.021 | -1 | 0.841 |
JAK2 |
0.761 | -0.125 | 1 | 0.780 |
JAK3 |
0.761 | -0.068 | 1 | 0.767 |
STLK3 |
0.760 | -0.177 | 1 | 0.739 |
TNNI3K_TYR |
0.760 | 0.053 | 1 | 0.779 |
DDR1 |
0.760 | -0.137 | 4 | 0.783 |
EPHA4 |
0.760 | -0.013 | 2 | 0.734 |
HCK |
0.759 | -0.024 | -1 | 0.828 |
FER |
0.759 | -0.084 | 1 | 0.846 |
CK1A |
0.758 | -0.100 | -3 | 0.366 |
NEK10_TYR |
0.757 | -0.041 | 1 | 0.688 |
SRMS |
0.757 | -0.022 | 1 | 0.843 |
EPHB3 |
0.757 | -0.013 | -1 | 0.834 |
INSRR |
0.757 | -0.089 | 3 | 0.677 |
EPHB1 |
0.757 | -0.039 | 1 | 0.841 |
BMX |
0.756 | 0.024 | -1 | 0.735 |
TNK2 |
0.756 | -0.044 | 3 | 0.686 |
EPHB2 |
0.756 | -0.009 | -1 | 0.831 |
JAK1 |
0.754 | -0.045 | 1 | 0.740 |
MERTK |
0.754 | -0.028 | 3 | 0.713 |
TNK1 |
0.753 | -0.063 | 3 | 0.732 |
KIT |
0.752 | -0.126 | 3 | 0.725 |
FGFR2 |
0.752 | -0.153 | 3 | 0.725 |
TEC |
0.752 | -0.027 | -1 | 0.739 |
KDR |
0.751 | -0.107 | 3 | 0.683 |
AXL |
0.750 | -0.109 | 3 | 0.710 |
PDGFRB |
0.750 | -0.185 | 3 | 0.739 |
FYN |
0.750 | 0.013 | -1 | 0.802 |
FLT3 |
0.749 | -0.167 | 3 | 0.742 |
MET |
0.749 | -0.100 | 3 | 0.723 |
TEK |
0.749 | -0.158 | 3 | 0.668 |
EPHA7 |
0.748 | -0.047 | 2 | 0.719 |
WEE1_TYR |
0.748 | -0.065 | -1 | 0.755 |
FGFR1 |
0.748 | -0.172 | 3 | 0.697 |
BTK |
0.747 | -0.163 | -1 | 0.765 |
PTK2B |
0.745 | -0.000 | -1 | 0.784 |
ALK |
0.745 | -0.145 | 3 | 0.642 |
EPHA1 |
0.745 | -0.084 | 3 | 0.701 |
PTK6 |
0.744 | -0.180 | -1 | 0.741 |
FRK |
0.743 | -0.092 | -1 | 0.845 |
EPHA3 |
0.743 | -0.131 | 2 | 0.699 |
LYN |
0.743 | -0.082 | 3 | 0.654 |
LTK |
0.743 | -0.139 | 3 | 0.665 |
DDR2 |
0.742 | -0.051 | 3 | 0.651 |
FLT1 |
0.741 | -0.132 | -1 | 0.845 |
NTRK1 |
0.741 | -0.209 | -1 | 0.831 |
INSR |
0.741 | -0.162 | 3 | 0.663 |
PDGFRA |
0.741 | -0.263 | 3 | 0.739 |
MATK |
0.740 | -0.107 | -1 | 0.759 |
EPHA5 |
0.740 | -0.064 | 2 | 0.712 |
FGFR3 |
0.739 | -0.179 | 3 | 0.690 |
PTK2 |
0.739 | 0.023 | -1 | 0.790 |
NTRK3 |
0.738 | -0.138 | -1 | 0.791 |
EPHA8 |
0.738 | -0.080 | -1 | 0.812 |
ERBB2 |
0.738 | -0.214 | 1 | 0.742 |
NTRK2 |
0.737 | -0.237 | 3 | 0.681 |
SRC |
0.737 | -0.084 | -1 | 0.801 |
FLT4 |
0.735 | -0.224 | 3 | 0.678 |
EGFR |
0.732 | -0.126 | 1 | 0.650 |
CSK |
0.732 | -0.169 | 2 | 0.722 |
SYK |
0.732 | -0.021 | -1 | 0.790 |
YANK2 |
0.731 | -0.153 | 2 | 0.381 |
CK1G3 |
0.730 | -0.137 | -3 | 0.319 |
EPHA2 |
0.730 | -0.073 | -1 | 0.784 |
FGFR4 |
0.729 | -0.143 | -1 | 0.790 |
IGF1R |
0.725 | -0.166 | 3 | 0.599 |
MUSK |
0.724 | -0.169 | 1 | 0.654 |
ERBB4 |
0.719 | -0.117 | 1 | 0.681 |
ZAP70 |
0.713 | -0.048 | -1 | 0.719 |
FES |
0.711 | -0.161 | -1 | 0.713 |
CK1G2 |
0.710 | -0.150 | -3 | 0.417 |