Motif 530 (n=169)

Position-wise Probabilities

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uniprot genes site source protein function
A0A024R4G9 C19orf48 S20 psp Chromosome 19 open reading frame 48 (Multidrug resistance-related protein, isoform CRA_a) None
A0A087WZ62 None S250 ochoa Mannosyltransferase (EC 2.4.1.-) None
A5PKW4 PSD S995 ochoa PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}.
O14497 ARID1A S1513 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14526 FCHO1 S622 ochoa F-BAR domain only protein 1 Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}.
O14578 CIT S1948 ochoa Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.
O15061 SYNM S1090 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15503 INSIG1 S125 psp Insulin-induced gene 1 protein (INSIG-1) Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}.
O43310 CTIF S292 ochoa CBP80/20-dependent translation initiation factor Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.
O43542 XRCC3 S225 psp DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3) Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.
O60271 SPAG9 S272 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60292 SIPA1L3 S1239 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60936 NOL3 S120 ochoa Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}.
O75128 COBL S962 ochoa Protein cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
O75369 FLNB S1384 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75521 ECI2 S283 ochoa Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. {ECO:0000269|PubMed:10419495}.
O75676 RPS6KA4 S721 ochoa Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
O75691 UTP20 S1734 ochoa Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}.
O76003 GLRX3 S118 ochoa Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}.
O94992 HEXIM1 S66 ochoa Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.
O95359 TACC2 S245 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
P04040 CAT S167 psp Catalase (EC 1.11.1.6) Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}.
P06127 CD5 S439 ochoa T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}.
P11137 MAP2 S1588 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P13796 LCP1 S406 ochoa Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}.
P13861 PRKAR2A S58 ochoa cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P16104 H2AX S122 ochoa Histone H2AX (H2a/x) (Histone H2A.X) Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}.
P20810 CAST S414 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P22674 CCNO S81 ochoa|psp Cyclin-O Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}.
P27987 ITPKB S29 ochoa Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
P31645 SLC6A4 S48 psp Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}.
P35269 GTF2F1 S433 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P35670 ATP7B S341 psp Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.
P43119 PTGIR S328 psp Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
P46087 NOP2 S599 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P48634 PRRC2A S908 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P50402 EMD S120 ochoa Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P50570 DNM2 S742 ochoa Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}.
P50747 HLCS S124 ochoa Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}.
P51617 IRAK1 S601 ochoa Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P55201 BRPF1 S844 ochoa Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.
P78356 PIP4K2B S319 ochoa Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}.
P78524 DENND2B S357 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
P78527 PRKDC S2056 psp DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q00872 MYBPC1 S162 ochoa Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.
Q07157 TJP1 S1180 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q07157 TJP1 S1433 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08050 FOXM1 S613 ochoa Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q12774 ARHGEF5 S627 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12906 ILF3 S190 ochoa Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
Q13164 MAPK7 S720 ochoa|psp Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Q13263 TRIM28 S417 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13370 PDE3B S554 ochoa cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}.
Q13469 NFATC2 S53 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13469 NFATC2 S704 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q14204 DYNC1H1 S3917 ochoa Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.
Q14469 HES1 S20 ochoa Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
Q14694 USP10 S27 ochoa Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}.
Q15014 MORF4L2 S90 ochoa Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Q15678 PTPN14 S438 ochoa Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Q15942 ZYX S205 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16799 RTN1 S335 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q16891 IMMT S583 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q2KJY2 KIF26B S1004 ochoa Kinesin-like protein KIF26B Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.
Q2LD37 BLTP1 S1361 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q3KQU3 MAP7D1 S809 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q52LW3 ARHGAP29 S1143 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q53T59 HS1BP3 S289 ochoa HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) May be a modulator of IL-2 signaling. {ECO:0000250}.
Q5JPB2 ZNF831 S918 ochoa Zinc finger protein 831 None
Q5SW79 CEP170 S239 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5SW79 CEP170 S1132 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5SW79 CEP170 S1384 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5VT52 RPRD2 S356 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q63ZY3 KANK2 S172 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q6N021 TET2 S936 ochoa Methylcytosine dioxygenase TET2 (EC 1.14.11.80) Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}.
Q6W2J9 BCOR S389 ochoa BCL-6 corepressor (BCoR) Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.
Q6ZUJ8 PIK3AP1 S573 ochoa Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
Q717R9 CYS1 S128 ochoa Cystin-1 (Cilia-associated protein) None
Q7RTP6 MICAL3 S1346 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z2K8 GPRIN1 S870 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z401 DENND4A S1606 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z434 MAVS S285 ochoa Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}.
Q86TI0 TBC1D1 S209 ochoa TBC1 domain family member 1 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86YS3 RAB11FIP4 S253 ochoa Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}.
Q8IVT5 KSR1 S267 ochoa Kinase suppressor of Ras 1 (EC 2.7.11.1) Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.
Q8IWE2 FAM114A1 S40 ochoa Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) May play a role in neuronal cell development. {ECO:0000250}.
Q8IWY9 CDAN1 S285 ochoa Codanin-1 May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}.
Q8IY92 SLX4 S956 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IY92 SLX4 S1631 psp Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8N122 RPTOR S606 psp Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}.
Q8N201 INTS1 S19 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8N3F8 MICALL1 S588 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N680 ZBTB2 S491 ochoa Zinc finger and BTB domain-containing protein 2 May be involved in transcriptional regulation.
Q8NCN4 RNF169 S471 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8NF91 SYNE1 S8277 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NF91 SYNE1 S8688 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NHV4 NEDD1 S548 ochoa Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TEH3 DENND1A S554 ochoa DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.
Q8TEJ3 SH3RF3 S438 ochoa E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}.
Q8TEW8 PARD3B S140 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUF5 PPP1R13L S225 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WWI1 LMO7 S322 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WXE0 CASKIN2 S825 ochoa Caskin-2 (CASK-interacting protein 2) None
Q8WYL5 SSH1 S834 ochoa|psp Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
Q92508 PIEZO1 S393 ochoa Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}.
Q96F63 CCDC97 S29 ochoa Coiled-coil domain-containing protein 97 May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}.
Q96HP0 DOCK6 S1230 ochoa Dedicator of cytokinesis protein 6 Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}.
Q96L14 CEP170P1 S93 ochoa Cep170-like protein (CEP170 pseudogene 1) None
Q96PL5 ERMAP S421 ochoa Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen) Possible role as a cell-adhesion or receptor molecule of erythroid cells.
Q96QB1 DLC1 S599 ochoa Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.
Q96RT1 ERBIN S1112 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q99459 CDC5L S293 ochoa Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}.
Q99706 KIR2DL4 S81 ochoa Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}.
Q9BRR9 ARHGAP9 S279 ochoa Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.
Q9BT88 SYT11 S144 ochoa Synaptotagmin-11 (Synaptotagmin XI) (SytXI) Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:27278822}.
Q9BU70 TRMO S214 ochoa tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity). {ECO:0000250|UniProtKB:P28634, ECO:0000269|PubMed:25063302}.
Q9BUF5 TUBB6 S56 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BVG9 PTDSS2 S24 ochoa Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:Q9Z1X2, ECO:0000269|PubMed:19014349}.
Q9BVV6 KIAA0586 S321 ochoa Protein TALPID3 Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}.
Q9BYV9 BACH2 S315 ochoa Transcription regulator protein BACH2 (BTB and CNC homolog 2) Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}.
Q9BZL4 PPP1R12C S327 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9BZL6 PRKD2 S375 ochoa Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}.
Q9C0C2 TNKS1BP1 S976 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S1371 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S1418 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S1506 ochoa 182 kDa tankyrase-1-binding protein None
Q9H0E3 SAP130 S442 ochoa Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.
Q9H0J9 PARP12 S633 ochoa Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}.
Q9H334 FOXP1 S37 ochoa Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.
Q9H4E7 DEF6 S568 ochoa Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}.
Q9H4L7 SMARCAD1 S67 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H792 PEAK1 S1148 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9HCD5 NCOA5 S378 ochoa Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
Q9HCD5 NCOA5 S416 ochoa Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
Q9NQ25 SLAMF7 S305 ochoa SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation.
Q9NR48 ASH1L S882 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NRH2 SNRK S383 ochoa SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}.
Q9NZ09 UBAP1 S250 ochoa Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}.
Q9NZJ0 DTL S425 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9UDT6 CLIP2 S173 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UIS9 MBD1 S518 ochoa Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}.
Q9UKJ3 GPATCH8 S738 ochoa G patch domain-containing protein 8 None
Q9UL51 HCN2 S80 ochoa Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}.
Q9ULI0 ATAD2B S140 ochoa ATPase family AAA domain-containing protein 2B None
Q9UMS6 SYNPO2 S226 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UN30 SCML1 S176 ochoa Sex comb on midleg-like protein 1 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}.
Q9UPN3 MACF1 S6969 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPN4 CEP131 S146 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UQP3 TNN S937 ochoa Tenascin-N (TN-N) (Tenascin-W) (TN-W) Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}.
Q9UQR1 ZNF148 S727 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y3Q8 TSC22D4 S225 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y3S1 WNK2 S1846 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4G8 RAPGEF2 S498 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
Q9Y520 PRRC2C S375 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y6D6 ARFGEF1 S1580 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.
Q9Y696 CLIC4 S31 Sugiyama Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}.
O14965 AURKA S98 GPS6|ELM|EPSD|PSP Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
O15111 CHUK S414 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}.
P29401 TKT S443 Sugiyama Transketolase (TK) (EC 2.2.1.1) Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.
Q6IBS0 TWF2 S139 Sugiyama Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
P21333 FLNA S732 Sugiyama Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P13674 P4HA1 S387 Sugiyama Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.
O95071 UBR5 S2384 Sugiyama E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O15372 EIF3H S302 Sugiyama Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
P78406 RAE1 S74 Sugiyama mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) Acts as a mRNA export factor involved in nucleocytoplasmic transport (PubMed:20498086, PubMed:33849972). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455). {ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:20498086, ECO:0000269|PubMed:33849972}.
O94842 TOX4 S575 Sugiyama TOX high mobility group box family member 4 Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.
Q96EP5 DAZAP1 S193 Sugiyama DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) RNA-binding protein, which may be required during spermatogenesis.
Q6GYQ0 RALGAPA1 S1280 Sugiyama Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q9Y6M4 CSNK1G3 S372 Sugiyama Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.
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reactome_id name p -log10_p
R-HSA-5602636 IKBKB deficiency causes SCID 0.033341 1.477
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.033341 1.477
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.044208 1.355
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.044208 1.355
R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.044208 1.355
R-HSA-198765 Signalling to ERK5 0.044208 1.355
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.044208 1.355
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.044208 1.355
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.044208 1.355
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.044208 1.355
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.044208 1.355
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.044208 1.355
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.044208 1.355
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.044208 1.355
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.044208 1.355
R-HSA-1296061 HCN channels 0.065577 1.183
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.011224 1.950
R-HSA-937039 IRAK1 recruits IKK complex 0.014446 1.840
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.014446 1.840
R-HSA-109703 PKB-mediated events 0.086471 1.063
R-HSA-165160 PDE3B signalling 0.086471 1.063
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 0.106901 0.971
R-HSA-8854518 AURKA Activation by TPX2 0.001647 2.783
R-HSA-202670 ERKs are inactivated 0.156008 0.807
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.008988 2.046
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.008988 2.046
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.005186 2.285
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.013969 1.855
R-HSA-380287 Centrosome maturation 0.015138 1.820
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.237731 0.624
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.237731 0.624
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.246311 0.609
R-HSA-72165 mRNA Splicing - Minor Pathway 0.125094 0.903
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.132642 0.877
R-HSA-6803529 FGFR2 alternative splicing 0.271479 0.566
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.279681 0.553
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.279681 0.553
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.279681 0.553
R-HSA-73772 RNA Polymerase I Promoter Escape 0.148034 0.830
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.287791 0.541
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.151937 0.818
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.295810 0.529
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.311580 0.506
R-HSA-171306 Packaging Of Telomere Ends 0.311580 0.506
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.311580 0.506
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.179775 0.745
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.319333 0.496
R-HSA-113418 Formation of the Early Elongation Complex 0.319333 0.496
R-HSA-167287 HIV elongation arrest and recovery 0.319333 0.496
R-HSA-167290 Pausing and recovery of HIV elongation 0.319333 0.496
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.220677 0.656
R-HSA-141424 Amplification of signal from the kinetochores 0.287252 0.542
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.287252 0.542
R-HSA-209543 p75NTR recruits signalling complexes 0.014446 1.840
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.026720 1.573
R-HSA-9842860 Regulation of endogenous retroelements 0.137078 0.863
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.093806 1.028
R-HSA-156711 Polo-like kinase mediated events 0.229054 0.640
R-HSA-193639 p75NTR signals via NF-kB 0.019927 1.701
R-HSA-191650 Regulation of gap junction activity 0.065577 1.183
R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.106901 0.971
R-HSA-190873 Gap junction degradation 0.126876 0.897
R-HSA-933542 TRAF6 mediated NF-kB activation 0.045853 1.339
R-HSA-163615 PKA activation 0.229054 0.640
R-HSA-73863 RNA Polymerase I Transcription Termination 0.311580 0.506
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.246311 0.609
R-HSA-427413 NoRC negatively regulates rRNA expression 0.061244 1.213
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.224815 0.648
R-HSA-5693537 Resolution of D-Loop Structures 0.075843 1.120
R-HSA-2025928 Calcineurin activates NFAT 0.008368 2.077
R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 0.106901 0.971
R-HSA-3323169 Defects in biotin (Btn) metabolism 0.126876 0.897
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.072618 1.139
R-HSA-389977 Post-chaperonin tubulin folding pathway 0.246311 0.609
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.078805 1.103
R-HSA-1221632 Meiotic synapsis 0.151937 0.818
R-HSA-9609690 HCMV Early Events 0.036436 1.438
R-HSA-162599 Late Phase of HIV Life Cycle 0.271359 0.566
R-HSA-73864 RNA Polymerase I Transcription 0.253911 0.595
R-HSA-212165 Epigenetic regulation of gene expression 0.194060 0.712
R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 0.136696 0.864
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.184174 0.735
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.193353 0.714
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.211405 0.675
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.245581 0.610
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.128855 0.890
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.014446 1.840
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.103142 0.987
R-HSA-198753 ERK/MAPK targets 0.254795 0.594
R-HSA-8856828 Clathrin-mediated endocytosis 0.274403 0.562
R-HSA-9758274 Regulation of NF-kappa B signaling 0.202430 0.694
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.211405 0.675
R-HSA-111446 Activation of BIM and translocation to mitochondria 0.054952 1.260
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.065577 1.183
R-HSA-5624138 Trafficking of myristoylated proteins to the cilium 0.076083 1.119
R-HSA-1483101 Synthesis of PS 0.086471 1.063
R-HSA-5603029 IkBA variant leads to EDA-ID 0.086471 1.063
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.021919 1.659
R-HSA-196025 Formation of annular gap junctions 0.116944 0.932
R-HSA-177135 Conjugation of benzoate with glycine 0.146407 0.834
R-HSA-209560 NF-kB is activated and signals survival 0.156008 0.807
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.165503 0.781
R-HSA-380615 Serotonin clearance from the synaptic cleft 0.165503 0.781
R-HSA-177128 Conjugation of salicylate with glycine 0.165503 0.781
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.174891 0.757
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.193353 0.714
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.072618 1.139
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.220279 0.657
R-HSA-164378 PKA activation in glucagon signalling 0.229054 0.640
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.237731 0.624
R-HSA-5620924 Intraflagellar transport 0.132642 0.877
R-HSA-8949613 Cristae formation 0.311580 0.506
R-HSA-73728 RNA Polymerase I Promoter Opening 0.311580 0.506
R-HSA-168325 Viral Messenger RNA Synthesis 0.183815 0.736
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.208305 0.681
R-HSA-1500620 Meiosis 0.283088 0.548
R-HSA-5693532 DNA Double-Strand Break Repair 0.129942 0.886
R-HSA-162587 HIV Life Cycle 0.317304 0.499
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.254795 0.594
R-HSA-9609646 HCMV Infection 0.034862 1.458
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.158150 0.801
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.184174 0.735
R-HSA-9932451 SWI/SNF chromatin remodelers 0.295810 0.529
R-HSA-9932444 ATP-dependent chromatin remodelers 0.295810 0.529
R-HSA-5617833 Cilium Assembly 0.032450 1.489
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.126933 0.896
R-HSA-5578749 Transcriptional regulation by small RNAs 0.228959 0.640
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.158150 0.801
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.126933 0.896
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.126933 0.896
R-HSA-69275 G2/M Transition 0.009223 2.035
R-HSA-196780 Biotin transport and metabolism 0.193353 0.714
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.155463 0.808
R-HSA-453274 Mitotic G2-G2/M phases 0.009690 2.014
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.169041 0.772
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.174891 0.757
R-HSA-157858 Gap junction trafficking and regulation 0.027448 1.561
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.177348 0.751
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.191436 0.718
R-HSA-68877 Mitotic Prometaphase 0.094044 1.027
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.191436 0.718
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.200022 0.699
R-HSA-525793 Myogenesis 0.303740 0.517
R-HSA-68875 Mitotic Prophase 0.194287 0.712
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.200022 0.699
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.003831 2.417
R-HSA-9729555 Sensory perception of sour taste 0.065577 1.183
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.018016 1.744
R-HSA-8847453 Synthesis of PIPs in the nucleus 0.106901 0.971
R-HSA-9646399 Aggrephagy 0.016687 1.778
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 0.174891 0.757
R-HSA-177504 Retrograde neurotrophin signalling 0.184174 0.735
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.004162 2.381
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.193353 0.714
R-HSA-190872 Transport of connexons to the plasma membrane 0.229054 0.640
R-HSA-159424 Conjugation of carboxylic acids 0.237731 0.624
R-HSA-156587 Amino Acid conjugation 0.237731 0.624
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.237731 0.624
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.059420 1.226
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.254795 0.594
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.287791 0.541
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.319333 0.496
R-HSA-446652 Interleukin-1 family signaling 0.127981 0.893
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.287791 0.541
R-HSA-2980766 Nuclear Envelope Breakdown 0.167743 0.775
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.197149 0.705
R-HSA-446353 Cell-extracellular matrix interactions 0.019927 1.701
R-HSA-190828 Gap junction trafficking 0.117655 0.929
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.171797 0.765
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.004813 2.318
R-HSA-9762293 Regulation of CDH11 gene transcription 0.126876 0.897
R-HSA-437239 Recycling pathway of L1 0.025061 1.601
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.035309 1.452
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.091595 1.038
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.202904 0.693
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.229054 0.640
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.233108 0.632
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.120267 0.920
R-HSA-9610379 HCMV Late Events 0.317304 0.499
R-HSA-68886 M Phase 0.088535 1.053
R-HSA-5693538 Homology Directed Repair 0.188595 0.724
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.012790 1.893
R-HSA-389542 NADPH regeneration 0.096743 1.014
R-HSA-1462054 Alpha-defensins 0.116944 0.932
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.184174 0.735
R-HSA-450294 MAP kinase activation 0.044204 1.355
R-HSA-166208 mTORC1-mediated signalling 0.271479 0.566
R-HSA-429947 Deadenylation of mRNA 0.287791 0.541
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.191934 0.717
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.160852 0.794
R-HSA-1852241 Organelle biogenesis and maintenance 0.092731 1.033
R-HSA-166166 MyD88-independent TLR4 cascade 0.160852 0.794
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.147490 0.831
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.202904 0.693
R-HSA-168898 Toll-like Receptor Cascades 0.214891 0.668
R-HSA-199991 Membrane Trafficking 0.041420 1.383
R-HSA-448424 Interleukin-17 signaling 0.059420 1.226
R-HSA-1474165 Reproduction 0.084987 1.071
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.014446 1.840
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.121968 0.914
R-HSA-8856688 Golgi-to-ER retrograde transport 0.088254 1.054
R-HSA-193704 p75 NTR receptor-mediated signalling 0.129443 0.888
R-HSA-8878171 Transcriptional regulation by RUNX1 0.147819 0.830
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.109091 0.962
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.224815 0.648
R-HSA-5653656 Vesicle-mediated transport 0.147032 0.833
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.193353 0.714
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.263184 0.580
R-HSA-3214847 HATs acetylate histones 0.037086 1.431
R-HSA-200425 Carnitine shuttle 0.279681 0.553
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.311580 0.506
R-HSA-4839726 Chromatin organization 0.034280 1.465
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.226293 0.645
R-HSA-73894 DNA Repair 0.261067 0.583
R-HSA-2132295 MHC class II antigen presentation 0.071047 1.148
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.229054 0.640
R-HSA-3214858 RMTs methylate histone arginines 0.117655 0.929
R-HSA-9705683 SARS-CoV-2-host interactions 0.151328 0.820
R-HSA-1640170 Cell Cycle 0.204223 0.690
R-HSA-9833482 PKR-mediated signaling 0.018326 1.737
R-HSA-9007101 Rab regulation of trafficking 0.185766 0.731
R-HSA-69278 Cell Cycle, Mitotic 0.130461 0.885
R-HSA-74160 Gene expression (Transcription) 0.091147 1.040
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.086471 1.063
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.220279 0.657
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.229054 0.640
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.136455 0.865
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 0.287791 0.541
R-HSA-6807878 COPI-mediated anterograde transport 0.121968 0.914
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.139931 0.854
R-HSA-3247509 Chromatin modifying enzymes 0.026320 1.580
R-HSA-9609507 Protein localization 0.305010 0.516
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.174891 0.757
R-HSA-1632852 Macroautophagy 0.105475 0.977
R-HSA-9010642 ROBO receptors bind AKAP5 0.116944 0.932
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.136696 0.864
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.263184 0.580
R-HSA-983189 Kinesins 0.179775 0.745
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.003667 2.436
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.063226 1.199
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.270586 0.568
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.082426 1.084
R-HSA-9612973 Autophagy 0.048726 1.312
R-HSA-73887 Death Receptor Signaling 0.131915 0.880
R-HSA-428643 Organic anion transport by SLC5/17/25 transporters 0.229054 0.640
R-HSA-175474 Assembly Of The HIV Virion 0.263184 0.580
R-HSA-1169408 ISG15 antiviral mechanism 0.241420 0.617
R-HSA-68882 Mitotic Anaphase 0.278173 0.556
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.155323 0.809
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.280672 0.552
R-HSA-73893 DNA Damage Bypass 0.136455 0.865
R-HSA-9033241 Peroxisomal protein import 0.175750 0.755
R-HSA-73857 RNA Polymerase II Transcription 0.111862 0.951
R-HSA-430116 GP1b-IX-V activation signalling 0.126876 0.897
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.035456 1.450
R-HSA-391908 Prostanoid ligand receptors 0.146407 0.834
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.165503 0.781
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.237731 0.624
R-HSA-9827857 Specification of primordial germ cells 0.026137 1.583
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.228959 0.640
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.116944 0.932
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.174891 0.757
R-HSA-9860931 Response of endothelial cells to shear stress 0.142252 0.847
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.262247 0.581
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.179775 0.745
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.179775 0.745
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.179775 0.745
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.179775 0.745
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.178236 0.749
R-HSA-5633007 Regulation of TP53 Activity 0.144010 0.842
R-HSA-1980145 Signaling by NOTCH2 0.079113 1.102
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.211405 0.675
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.237731 0.624
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.287791 0.541
R-HSA-8863678 Neurodegenerative Diseases 0.287791 0.541
R-HSA-9663891 Selective autophagy 0.098294 1.007
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.220677 0.656
R-HSA-913531 Interferon Signaling 0.175108 0.757
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.311580 0.506
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.262247 0.581
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.236363 0.626
R-HSA-9855142 Cellular responses to mechanical stimuli 0.171797 0.765
R-HSA-9012852 Signaling by NOTCH3 0.159803 0.796
R-HSA-9645723 Diseases of programmed cell death 0.299728 0.523
R-HSA-446728 Cell junction organization 0.123548 0.908
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.220677 0.656
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.226754 0.644
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.051421 1.289
R-HSA-186712 Regulation of beta-cell development 0.175750 0.755
R-HSA-1980143 Signaling by NOTCH1 0.245581 0.610
R-HSA-438064 Post NMDA receptor activation events 0.295573 0.529
R-HSA-373760 L1CAM interactions 0.182948 0.738
R-HSA-9008059 Interleukin-37 signaling 0.063226 1.199
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.271479 0.566
R-HSA-418990 Adherens junctions interactions 0.283175 0.548
R-HSA-1500931 Cell-Cell communication 0.182197 0.739
R-HSA-9006925 Intracellular signaling by second messengers 0.227649 0.643
R-HSA-8983711 OAS antiviral response 0.165503 0.781
R-HSA-391903 Eicosanoid ligand-binding receptors 0.246311 0.609
R-HSA-212436 Generic Transcription Pathway 0.121208 0.916
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.106722 0.972
R-HSA-3700989 Transcriptional Regulation by TP53 0.311604 0.506
R-HSA-1257604 PIP3 activates AKT signaling 0.285132 0.545
R-HSA-168638 NOD1/2 Signaling Pathway 0.079113 1.102
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.279681 0.553
R-HSA-1834941 STING mediated induction of host immune responses 0.237731 0.624
R-HSA-8986944 Transcriptional Regulation by MECP2 0.027580 1.559
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.179775 0.745
R-HSA-199977 ER to Golgi Anterograde Transport 0.286615 0.543
R-HSA-9013694 Signaling by NOTCH4 0.237262 0.625
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.054290 1.265
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.167743 0.775
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.055850 1.253
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.117655 0.929
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.319333 0.496
R-HSA-2028269 Signaling by Hippo 0.220279 0.657
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.200100 0.699
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.196011 0.708
R-HSA-9020591 Interleukin-12 signaling 0.245581 0.610
R-HSA-447115 Interleukin-12 family signaling 0.295573 0.529
R-HSA-5334118 DNA methylation 0.326999 0.485
R-HSA-72086 mRNA Capping 0.326999 0.485
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.326999 0.485
R-HSA-9615710 Late endosomal microautophagy 0.326999 0.485
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.326999 0.485
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.326999 0.485
R-HSA-5656169 Termination of translesion DNA synthesis 0.326999 0.485
R-HSA-180024 DARPP-32 events 0.326999 0.485
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.326999 0.485
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.332794 0.478
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.334580 0.476
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.334580 0.476
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.334580 0.476
R-HSA-8863795 Downregulation of ERBB2 signaling 0.334580 0.476
R-HSA-112311 Neurotransmitter clearance 0.334580 0.476
R-HSA-114452 Activation of BH3-only proteins 0.334580 0.476
R-HSA-2467813 Separation of Sister Chromatids 0.338835 0.470
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.340997 0.467
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.342075 0.466
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.342075 0.466
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.342075 0.466
R-HSA-162588 Budding and maturation of HIV virion 0.342075 0.466
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.342075 0.466
R-HSA-9833109 Evasion by RSV of host interferon responses 0.342075 0.466
R-HSA-8878159 Transcriptional regulation by RUNX3 0.345087 0.462
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.349486 0.457
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.349486 0.457
R-HSA-9614085 FOXO-mediated transcription 0.353242 0.452
R-HSA-1855170 IPs transport between nucleus and cytosol 0.356814 0.448
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.356814 0.448
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.356814 0.448
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.356814 0.448
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.356814 0.448
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.356814 0.448
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.356814 0.448
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.356814 0.448
R-HSA-69618 Mitotic Spindle Checkpoint 0.357307 0.447
R-HSA-70171 Glycolysis 0.357307 0.447
R-HSA-5610787 Hedgehog 'off' state 0.357307 0.447
R-HSA-9020702 Interleukin-1 signaling 0.361362 0.442
R-HSA-418555 G alpha (s) signalling events 0.363391 0.440
R-HSA-5621481 C-type lectin receptors (CLRs) 0.363391 0.440
R-HSA-390522 Striated Muscle Contraction 0.364061 0.439
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.364061 0.439
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.364061 0.439
R-HSA-163359 Glucagon signaling in metabolic regulation 0.364061 0.439
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.365408 0.437
R-HSA-421270 Cell-cell junction organization 0.366974 0.435
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.369512 0.432
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.369512 0.432
R-HSA-5673000 RAF activation 0.371226 0.430
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.371226 0.430
R-HSA-180746 Nuclear import of Rev protein 0.371226 0.430
R-HSA-190861 Gap junction assembly 0.371226 0.430
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.371226 0.430
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.373471 0.428
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.378310 0.422
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.378310 0.422
R-HSA-3296482 Defects in vitamin and cofactor metabolism 0.378310 0.422
R-HSA-212300 PRC2 methylates histones and DNA 0.385316 0.414
R-HSA-432720 Lysosome Vesicle Biogenesis 0.385316 0.414
R-HSA-111933 Calmodulin induced events 0.385316 0.414
R-HSA-111997 CaM pathway 0.385316 0.414
R-HSA-1839126 FGFR2 mutant receptor activation 0.385316 0.414
R-HSA-8853659 RET signaling 0.385316 0.414
R-HSA-8941326 RUNX2 regulates bone development 0.385316 0.414
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.389471 0.410
R-HSA-9700206 Signaling by ALK in cancer 0.389471 0.410
R-HSA-211000 Gene Silencing by RNA 0.389471 0.410
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.392242 0.406
R-HSA-427359 SIRT1 negatively regulates rRNA expression 0.392242 0.406
R-HSA-933541 TRAF6 mediated IRF7 activation 0.392242 0.406
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.392242 0.406
R-HSA-110331 Cleavage of the damaged purine 0.392242 0.406
R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.392242 0.406
R-HSA-5689896 Ovarian tumor domain proteases 0.392242 0.406
R-HSA-73927 Depurination 0.399092 0.399
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.399092 0.399
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.399092 0.399
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.399092 0.399
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.399092 0.399
R-HSA-9694516 SARS-CoV-2 Infection 0.404818 0.393
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.405864 0.392
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.405864 0.392
R-HSA-71336 Pentose phosphate pathway 0.405864 0.392
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.405864 0.392
R-HSA-1483249 Inositol phosphate metabolism 0.409213 0.388
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.412561 0.385
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.412561 0.385
R-HSA-167169 HIV Transcription Elongation 0.412561 0.385
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.412561 0.385
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.412561 0.385
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.412561 0.385
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.412561 0.385
R-HSA-177243 Interactions of Rev with host cellular proteins 0.412561 0.385
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.412561 0.385
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.412561 0.385
R-HSA-5260271 Diseases of Immune System 0.412561 0.385
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.419182 0.378
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.419182 0.378
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.419182 0.378
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.419182 0.378
R-HSA-3214841 PKMTs methylate histone lysines 0.419182 0.378
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.419182 0.378
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.425729 0.371
R-HSA-167161 HIV Transcription Initiation 0.425729 0.371
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.425729 0.371
R-HSA-9656223 Signaling by RAF1 mutants 0.425729 0.371
R-HSA-5674135 MAP2K and MAPK activation 0.425729 0.371
R-HSA-5675221 Negative regulation of MAPK pathway 0.425729 0.371
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.425729 0.371
R-HSA-442660 SLC-mediated transport of neurotransmitters 0.425729 0.371
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.428641 0.368
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.432203 0.364
R-HSA-165159 MTOR signalling 0.432203 0.364
R-HSA-111996 Ca-dependent events 0.432203 0.364
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.432203 0.364
R-HSA-110329 Cleavage of the damaged pyrimidine 0.432203 0.364
R-HSA-73928 Depyrimidination 0.432203 0.364
R-HSA-72163 mRNA Splicing - Major Pathway 0.432924 0.364
R-HSA-70326 Glucose metabolism 0.436319 0.360
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.437904 0.359
R-HSA-73776 RNA Polymerase II Promoter Escape 0.438604 0.358
R-HSA-9710421 Defective pyroptosis 0.438604 0.358
R-HSA-1461973 Defensins 0.438604 0.358
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.440138 0.356
R-HSA-8953897 Cellular responses to stimuli 0.447261 0.349
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.451192 0.346
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.451192 0.346
R-HSA-774815 Nucleosome assembly 0.451192 0.346
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.451192 0.346
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.451192 0.346
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.451192 0.346
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.451192 0.346
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.451192 0.346
R-HSA-6783310 Fanconi Anemia Pathway 0.451192 0.346
R-HSA-1489509 DAG and IP3 signaling 0.451192 0.346
R-HSA-3371556 Cellular response to heat stress 0.451507 0.345
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.451507 0.345
R-HSA-948021 Transport to the Golgi and subsequent modification 0.456503 0.341
R-HSA-2299718 Condensation of Prophase Chromosomes 0.457380 0.340
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.457380 0.340
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.457380 0.340
R-HSA-9649948 Signaling downstream of RAS mutants 0.457380 0.340
R-HSA-6802949 Signaling by RAS mutants 0.457380 0.340
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.457380 0.340
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.457380 0.340
R-HSA-5357905 Regulation of TNFR1 signaling 0.457380 0.340
R-HSA-75153 Apoptotic execution phase 0.457380 0.340
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.459423 0.338
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 0.463499 0.334
R-HSA-72172 mRNA Splicing 0.465241 0.332
R-HSA-1280215 Cytokine Signaling in Immune system 0.468435 0.329
R-HSA-9634597 GPER1 signaling 0.469550 0.328
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.469550 0.328
R-HSA-9031628 NGF-stimulated transcription 0.469550 0.328
R-HSA-9766229 Degradation of CDH1 0.475532 0.323
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.481175 0.318
R-HSA-109704 PI3K Cascade 0.481447 0.317
R-HSA-5655253 Signaling by FGFR2 in disease 0.481447 0.317
R-HSA-912446 Meiotic recombination 0.487296 0.312
R-HSA-1169091 Activation of NF-kappaB in B cells 0.487296 0.312
R-HSA-3371571 HSF1-dependent transactivation 0.487296 0.312
R-HSA-112382 Formation of RNA Pol II elongation complex 0.493079 0.307
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.493079 0.307
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.493079 0.307
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.498798 0.302
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.498798 0.302
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.498798 0.302
R-HSA-9639288 Amino acids regulate mTORC1 0.498798 0.302
R-HSA-72649 Translation initiation complex formation 0.504452 0.297
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.504452 0.297
R-HSA-3214815 HDACs deacetylate histones 0.510043 0.292
R-HSA-72702 Ribosomal scanning and start codon recognition 0.515571 0.288
R-HSA-193648 NRAGE signals death through JNK 0.515571 0.288
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.515571 0.288
R-HSA-75893 TNF signaling 0.515571 0.288
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.515571 0.288
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.515571 0.288
R-HSA-9018519 Estrogen-dependent gene expression 0.516849 0.287
R-HSA-163685 Integration of energy metabolism 0.516849 0.287
R-HSA-112399 IRS-mediated signalling 0.521037 0.283
R-HSA-9764561 Regulation of CDH1 Function 0.521037 0.283
R-HSA-5358351 Signaling by Hedgehog 0.523788 0.281
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.526442 0.279
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.526442 0.279
R-HSA-162906 HIV Infection 0.530017 0.276
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.531786 0.274
R-HSA-191859 snRNP Assembly 0.531786 0.274
R-HSA-194441 Metabolism of non-coding RNA 0.531786 0.274
R-HSA-429914 Deadenylation-dependent mRNA decay 0.531786 0.274
R-HSA-1227986 Signaling by ERBB2 0.537070 0.270
R-HSA-8943724 Regulation of PTEN gene transcription 0.537070 0.270
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.537070 0.270
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.537070 0.270
R-HSA-2428928 IRS-related events triggered by IGF1R 0.542295 0.266
R-HSA-112043 PLC beta mediated events 0.542295 0.266
R-HSA-445717 Aquaporin-mediated transport 0.542295 0.266
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.547461 0.262
R-HSA-6784531 tRNA processing in the nucleus 0.547461 0.262
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.547461 0.262
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.547461 0.262
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.547461 0.262
R-HSA-1280218 Adaptive Immune System 0.549344 0.260
R-HSA-2428924 IGF1R signaling cascade 0.557620 0.254
R-HSA-74751 Insulin receptor signalling cascade 0.557620 0.254
R-HSA-936837 Ion transport by P-type ATPases 0.557620 0.254
R-HSA-166520 Signaling by NTRKs 0.560746 0.251
R-HSA-1474244 Extracellular matrix organization 0.562174 0.250
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.562614 0.250
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.562614 0.250
R-HSA-162582 Signal Transduction 0.564567 0.248
R-HSA-157118 Signaling by NOTCH 0.564657 0.248
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.567552 0.246
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.570466 0.244
R-HSA-5693606 DNA Double Strand Break Response 0.572435 0.242
R-HSA-112040 G-protein mediated events 0.572435 0.242
R-HSA-167172 Transcription of the HIV genome 0.577262 0.239
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.577262 0.239
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.577262 0.239
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.577262 0.239
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.582036 0.235
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.583184 0.234
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.586756 0.232
R-HSA-3000178 ECM proteoglycans 0.591423 0.228
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.591423 0.228
R-HSA-453276 Regulation of mitotic cell cycle 0.591423 0.228
R-HSA-8978934 Metabolism of cofactors 0.591423 0.228
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.596037 0.225
R-HSA-449147 Signaling by Interleukins 0.597938 0.223
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.600600 0.221
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.600600 0.221
R-HSA-9749641 Aspirin ADME 0.600600 0.221
R-HSA-109581 Apoptosis 0.604773 0.218
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.605111 0.218
R-HSA-69473 G2/M DNA damage checkpoint 0.605111 0.218
R-HSA-1226099 Signaling by FGFR in disease 0.605111 0.218
R-HSA-71403 Citric acid cycle (TCA cycle) 0.609572 0.215
R-HSA-8852135 Protein ubiquitination 0.609572 0.215
R-HSA-917937 Iron uptake and transport 0.609572 0.215
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.609572 0.215
R-HSA-69620 Cell Cycle Checkpoints 0.609986 0.215
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.622656 0.206
R-HSA-9955298 SLC-mediated transport of organic anions 0.622656 0.206
R-HSA-416482 G alpha (12/13) signalling events 0.622656 0.206
R-HSA-9659379 Sensory processing of sound 0.626919 0.203
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.626919 0.203
R-HSA-6798695 Neutrophil degranulation 0.630469 0.200
R-HSA-5654738 Signaling by FGFR2 0.631135 0.200
R-HSA-2262752 Cellular responses to stress 0.631652 0.200
R-HSA-9711123 Cellular response to chemical stress 0.633781 0.198
R-HSA-5693607 Processing of DNA double-strand break ends 0.635303 0.197
R-HSA-977225 Amyloid fiber formation 0.635303 0.197
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.639425 0.194
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.643500 0.191
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.647529 0.189
R-HSA-390918 Peroxisomal lipid metabolism 0.647529 0.189
R-HSA-6802957 Oncogenic MAPK signaling 0.651513 0.186
R-HSA-9824446 Viral Infection Pathways 0.651781 0.186
R-HSA-168255 Influenza Infection 0.656388 0.183
R-HSA-2559583 Cellular Senescence 0.659092 0.181
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.659348 0.181
R-HSA-390466 Chaperonin-mediated protein folding 0.663199 0.178
R-HSA-168249 Innate Immune System 0.670203 0.174
R-HSA-1236974 ER-Phagosome pathway 0.670772 0.173
R-HSA-202424 Downstream TCR signaling 0.674494 0.171
R-HSA-73884 Base Excision Repair 0.674494 0.171
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.678175 0.169
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.680120 0.167
R-HSA-983712 Ion channel transport 0.682673 0.166
R-HSA-391251 Protein folding 0.685413 0.164
R-HSA-74752 Signaling by Insulin receptor 0.685413 0.164
R-HSA-68867 Assembly of the pre-replicative complex 0.688971 0.162
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.688971 0.162
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.692489 0.160
R-HSA-1474290 Collagen formation 0.692489 0.160
R-HSA-72689 Formation of a pool of free 40S subunits 0.699407 0.155
R-HSA-1296071 Potassium Channels 0.702808 0.153
R-HSA-157579 Telomere Maintenance 0.706170 0.151
R-HSA-190236 Signaling by FGFR 0.709494 0.149
R-HSA-422356 Regulation of insulin secretion 0.709494 0.149
R-HSA-2559580 Oxidative Stress Induced Senescence 0.722423 0.141
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.722423 0.141
R-HSA-1483255 PI Metabolism 0.722423 0.141
R-HSA-5357801 Programmed Cell Death 0.723583 0.141
R-HSA-111885 Opioid Signalling 0.728670 0.137
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.731742 0.136
R-HSA-5619507 Activation of HOX genes during differentiation 0.731742 0.136
R-HSA-9833110 RSV-host interactions 0.731742 0.136
R-HSA-418346 Platelet homeostasis 0.737781 0.132
R-HSA-9692914 SARS-CoV-1-host interactions 0.737781 0.132
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.739097 0.131
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.743685 0.129
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.743685 0.129
R-HSA-1236975 Antigen processing-Cross presentation 0.743685 0.129
R-HSA-2672351 Stimuli-sensing channels 0.743685 0.129
R-HSA-112315 Transmission across Chemical Synapses 0.746404 0.127
R-HSA-69002 DNA Replication Pre-Initiation 0.746587 0.127
R-HSA-202403 TCR signaling 0.749457 0.125
R-HSA-6803157 Antimicrobial peptides 0.752294 0.124
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.757873 0.120
R-HSA-8951664 Neddylation 0.757952 0.120
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.766008 0.116
R-HSA-422475 Axon guidance 0.769567 0.114
R-HSA-72737 Cap-dependent Translation Initiation 0.771279 0.113
R-HSA-72613 Eukaryotic Translation Initiation 0.771279 0.113
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.773719 0.111
R-HSA-1592230 Mitochondrial biogenesis 0.773871 0.111
R-HSA-8878166 Transcriptional regulation by RUNX2 0.778966 0.108
R-HSA-72312 rRNA processing 0.779397 0.108
R-HSA-9679506 SARS-CoV Infections 0.782534 0.106
R-HSA-73886 Chromosome Maintenance 0.783948 0.106
R-HSA-168256 Immune System 0.784773 0.105
R-HSA-8939211 ESR-mediated signaling 0.788586 0.103
R-HSA-162909 Host Interactions of HIV factors 0.791211 0.102
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.795918 0.099
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.795918 0.099
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.795918 0.099
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.798231 0.098
R-HSA-114608 Platelet degranulation 0.800519 0.097
R-HSA-69481 G2/M Checkpoints 0.800519 0.097
R-HSA-112316 Neuronal System 0.805665 0.094
R-HSA-9717189 Sensory perception of taste 0.811576 0.091
R-HSA-1474228 Degradation of the extracellular matrix 0.813713 0.090
R-HSA-9675108 Nervous system development 0.814752 0.089
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.815826 0.088
R-HSA-5688426 Deubiquitination 0.818942 0.087
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.826039 0.083
R-HSA-6807070 PTEN Regulation 0.829964 0.081
R-HSA-2871837 FCERI mediated NF-kB activation 0.841220 0.075
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.846948 0.072
R-HSA-9856651 MITF-M-dependent gene expression 0.851735 0.070
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.855083 0.068
R-HSA-8953854 Metabolism of RNA 0.855099 0.068
R-HSA-69306 DNA Replication 0.856729 0.067
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.858357 0.066
R-HSA-9711097 Cellular response to starvation 0.864684 0.063
R-HSA-5673001 RAF/MAP kinase cascade 0.865858 0.063
R-HSA-1483257 Phospholipid metabolism 0.872885 0.059
R-HSA-5684996 MAPK1/MAPK3 signaling 0.874023 0.058
R-HSA-5619102 SLC transporter disorders 0.877913 0.057
R-HSA-446203 Asparagine N-linked glycosylation 0.879418 0.056
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.883371 0.054
R-HSA-72306 tRNA processing 0.883371 0.054
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.886009 0.053
R-HSA-5689880 Ub-specific processing proteases 0.887305 0.052
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.887305 0.052
R-HSA-9664433 Leishmania parasite growth and survival 0.887305 0.052
R-HSA-9678108 SARS-CoV-1 Infection 0.889854 0.051
R-HSA-109582 Hemostasis 0.896171 0.048
R-HSA-201681 TCF dependent signaling in response to WNT 0.899490 0.046
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.907254 0.042
R-HSA-389948 Co-inhibition by PD-1 0.917270 0.038
R-HSA-428157 Sphingolipid metabolism 0.918213 0.037
R-HSA-376176 Signaling by ROBO receptors 0.920066 0.036
R-HSA-1483206 Glycerophospholipid biosynthesis 0.920066 0.036
R-HSA-5683057 MAPK family signaling cascades 0.921032 0.036
R-HSA-397014 Muscle contraction 0.928724 0.032
R-HSA-9730414 MITF-M-regulated melanocyte development 0.929536 0.032
R-HSA-9006931 Signaling by Nuclear Receptors 0.932007 0.031
R-HSA-196854 Metabolism of vitamins and cofactors 0.932643 0.030
R-HSA-9748784 Drug ADME 0.933464 0.030
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.942024 0.026
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.944244 0.025
R-HSA-156580 Phase II - Conjugation of compounds 0.947717 0.023
R-HSA-388396 GPCR downstream signalling 0.948721 0.023
R-HSA-425407 SLC-mediated transmembrane transport 0.951211 0.022
R-HSA-5619115 Disorders of transmembrane transporters 0.952308 0.021
R-HSA-8978868 Fatty acid metabolism 0.955673 0.020
R-HSA-5663205 Infectious disease 0.956783 0.019
R-HSA-388841 Regulation of T cell activation by CD28 family 0.956996 0.019
R-HSA-9734767 Developmental Cell Lineages 0.960323 0.018
R-HSA-416476 G alpha (q) signalling events 0.960776 0.017
R-HSA-76002 Platelet activation, signaling and aggregation 0.965041 0.015
R-HSA-9658195 Leishmania infection 0.967748 0.014
R-HSA-9824443 Parasitic Infection Pathways 0.967748 0.014
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.968117 0.014
R-HSA-597592 Post-translational protein modification 0.971858 0.012
R-HSA-372790 Signaling by GPCR 0.972426 0.012
R-HSA-382551 Transport of small molecules 0.972788 0.012
R-HSA-195721 Signaling by WNT 0.973486 0.012
R-HSA-1643685 Disease 0.974914 0.011
R-HSA-8957322 Metabolism of steroids 0.980358 0.009
R-HSA-1266738 Developmental Biology 0.981386 0.008
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.983861 0.007
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.991365 0.004
R-HSA-418594 G alpha (i) signalling events 0.992574 0.003
R-HSA-5668914 Diseases of metabolism 0.994114 0.003
R-HSA-72766 Translation 0.994249 0.003
R-HSA-211859 Biological oxidations 0.998079 0.001
R-HSA-500792 GPCR ligand binding 0.999114 0.000
R-HSA-392499 Metabolism of proteins 0.999128 0.000
R-HSA-556833 Metabolism of lipids 0.999583 0.000
R-HSA-9709957 Sensory Perception 0.999994 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.880 0.196 2 0.880
CLK3CLK3 0.874 0.253 1 0.823
PIM3PIM3 0.872 0.207 -3 0.843
NDR2NDR2 0.871 0.173 -3 0.846
RSK2RSK2 0.868 0.192 -3 0.776
CDC7CDC7 0.864 0.059 1 0.798
MTORMTOR 0.863 0.051 1 0.791
PRKD1PRKD1 0.862 0.185 -3 0.839
SKMLCKSKMLCK 0.861 0.203 -2 0.884
PRKD2PRKD2 0.861 0.182 -3 0.785
P90RSKP90RSK 0.861 0.142 -3 0.777
PIM1PIM1 0.861 0.191 -3 0.792
NDR1NDR1 0.860 0.109 -3 0.836
AURCAURC 0.860 0.231 -2 0.720
MOSMOS 0.859 0.083 1 0.822
PRPKPRPK 0.858 -0.034 -1 0.839
SRPK1SRPK1 0.858 0.140 -3 0.757
CAMK1BCAMK1B 0.858 0.077 -3 0.867
HIPK4HIPK4 0.858 0.185 1 0.766
NLKNLK 0.858 0.077 1 0.819
RSK3RSK3 0.857 0.129 -3 0.769
ERK5ERK5 0.857 0.129 1 0.828
RAF1RAF1 0.857 -0.020 1 0.826
CDKL1CDKL1 0.857 0.097 -3 0.805
MST4MST4 0.857 0.111 2 0.862
WNK1WNK1 0.857 0.108 -2 0.905
ATRATR 0.856 0.073 1 0.829
IKKBIKKB 0.856 -0.044 -2 0.745
PKACGPKACG 0.855 0.134 -2 0.788
CDKL5CDKL5 0.855 0.123 -3 0.800
MAPKAPK2MAPKAPK2 0.854 0.132 -3 0.735
GRK1GRK1 0.853 0.123 -2 0.779
LATS2LATS2 0.853 0.088 -5 0.782
TBK1TBK1 0.853 -0.044 1 0.734
CAMK2GCAMK2G 0.853 -0.010 2 0.821
GCN2GCN2 0.853 -0.113 2 0.815
PDHK4PDHK4 0.852 -0.172 1 0.838
RSK4RSK4 0.852 0.165 -3 0.745
CAMK2DCAMK2D 0.852 0.083 -3 0.851
PKACBPKACB 0.851 0.192 -2 0.729
MAPKAPK3MAPKAPK3 0.851 0.085 -3 0.783
PKN3PKN3 0.851 0.030 -3 0.836
KISKIS 0.850 0.111 1 0.682
ICKICK 0.850 0.121 -3 0.843
NIKNIK 0.850 0.067 -3 0.885
DSTYKDSTYK 0.850 -0.055 2 0.881
CAMLCKCAMLCK 0.850 0.105 -2 0.880
GRK5GRK5 0.850 -0.008 -3 0.873
CLK2CLK2 0.850 0.227 -3 0.757
PKN2PKN2 0.849 0.049 -3 0.847
P70S6KBP70S6KB 0.849 0.095 -3 0.799
CHAK2CHAK2 0.849 0.029 -1 0.863
IKKEIKKE 0.849 -0.076 1 0.728
CAMK2ACAMK2A 0.849 0.134 2 0.816
BMPR2BMPR2 0.849 -0.115 -2 0.864
NUAK2NUAK2 0.848 0.034 -3 0.852
RIPK3RIPK3 0.848 -0.032 3 0.635
ULK2ULK2 0.848 -0.132 2 0.782
PKCDPKCD 0.848 0.089 2 0.777
PDHK1PDHK1 0.848 -0.124 1 0.823
DAPK2DAPK2 0.848 0.101 -3 0.872
PAK1PAK1 0.847 0.125 -2 0.835
MARK4MARK4 0.847 0.030 4 0.843
PRKXPRKX 0.847 0.187 -3 0.689
CAMK2BCAMK2B 0.847 0.113 2 0.800
IKKAIKKA 0.846 0.014 -2 0.721
AMPKA1AMPKA1 0.846 0.045 -3 0.866
HUNKHUNK 0.846 -0.059 2 0.827
GRK6GRK6 0.846 0.057 1 0.822
MSK1MSK1 0.846 0.143 -3 0.751
SRPK2SRPK2 0.845 0.091 -3 0.677
CLK4CLK4 0.845 0.156 -3 0.772
DYRK2DYRK2 0.844 0.121 1 0.683
MNK2MNK2 0.844 0.124 -2 0.836
MSK2MSK2 0.843 0.069 -3 0.746
NEK6NEK6 0.843 -0.055 -2 0.826
TSSK1TSSK1 0.843 0.090 -3 0.888
MASTLMASTL 0.843 -0.106 -2 0.831
TGFBR2TGFBR2 0.843 -0.059 -2 0.752
MLK1MLK1 0.843 -0.093 2 0.809
AURBAURB 0.842 0.158 -2 0.722
PAK3PAK3 0.842 0.076 -2 0.832
PKCBPKCB 0.842 0.073 2 0.725
PKCAPKCA 0.842 0.093 2 0.716
CDK18CDK18 0.841 0.098 1 0.613
NIM1NIM1 0.841 0.002 3 0.676
CDK8CDK8 0.841 0.039 1 0.661
PKCGPKCG 0.841 0.058 2 0.730
PAK6PAK6 0.841 0.139 -2 0.777
LATS1LATS1 0.841 0.116 -3 0.844
CLK1CLK1 0.840 0.139 -3 0.752
DLKDLK 0.840 -0.061 1 0.831
AMPKA2AMPKA2 0.840 0.036 -3 0.831
BCKDKBCKDK 0.840 -0.133 -1 0.775
MLK2MLK2 0.840 -0.021 2 0.816
HIPK2HIPK2 0.840 0.151 1 0.598
TSSK2TSSK2 0.840 0.020 -5 0.850
CDK19CDK19 0.840 0.061 1 0.627
GRK7GRK7 0.839 0.117 1 0.774
PRKD3PRKD3 0.839 0.075 -3 0.752
MNK1MNK1 0.839 0.109 -2 0.836
CDK7CDK7 0.839 0.040 1 0.665
WNK3WNK3 0.838 -0.161 1 0.808
PIM2PIM2 0.838 0.142 -3 0.752
BMPR1BBMPR1B 0.838 0.107 1 0.788
SRPK3SRPK3 0.838 0.063 -3 0.725
PKG2PKG2 0.838 0.122 -2 0.729
PKCZPKCZ 0.838 0.070 2 0.771
NEK7NEK7 0.838 -0.192 -3 0.826
CDK1CDK1 0.838 0.060 1 0.633
IRE1IRE1 0.838 -0.025 1 0.802
RIPK1RIPK1 0.838 -0.101 1 0.816
HIPK1HIPK1 0.837 0.142 1 0.711
CAMK4CAMK4 0.837 -0.025 -3 0.831
AKT2AKT2 0.837 0.112 -3 0.697
P38AP38A 0.837 0.103 1 0.713
QSKQSK 0.836 0.042 4 0.819
ULK1ULK1 0.836 -0.191 -3 0.810
MYLK4MYLK4 0.836 0.078 -2 0.813
CDK13CDK13 0.836 0.043 1 0.641
SGK3SGK3 0.836 0.109 -3 0.770
PKRPKR 0.836 0.092 1 0.833
AURAAURA 0.836 0.127 -2 0.694
P38BP38B 0.836 0.106 1 0.642
NEK9NEK9 0.835 -0.114 2 0.836
DNAPKDNAPK 0.835 0.085 1 0.705
MLK3MLK3 0.835 -0.029 2 0.734
PAK2PAK2 0.834 0.055 -2 0.826
SMG1SMG1 0.834 0.034 1 0.787
JNK2JNK2 0.834 0.083 1 0.610
MELKMELK 0.834 0.008 -3 0.814
CDK5CDK5 0.834 0.062 1 0.688
PKACAPKACA 0.834 0.147 -2 0.682
GRK4GRK4 0.833 -0.109 -2 0.792
FAM20CFAM20C 0.833 0.013 2 0.583
QIKQIK 0.833 -0.047 -3 0.844
ANKRD3ANKRD3 0.833 -0.137 1 0.849
ALK4ALK4 0.833 -0.009 -2 0.791
TGFBR1TGFBR1 0.833 0.030 -2 0.756
PASKPASK 0.833 0.151 -3 0.860
ATMATM 0.832 -0.016 1 0.762
DCAMKL1DCAMKL1 0.832 0.080 -3 0.797
PKCHPKCH 0.832 0.013 2 0.710
YSK4YSK4 0.832 -0.049 1 0.781
CDK12CDK12 0.831 0.048 1 0.612
CDK9CDK9 0.831 0.027 1 0.652
CDK10CDK10 0.831 0.106 1 0.643
JNK3JNK3 0.830 0.049 1 0.642
ERK1ERK1 0.830 0.064 1 0.631
MST3MST3 0.830 0.102 2 0.838
MPSK1MPSK1 0.830 0.218 1 0.829
GSK3AGSK3A 0.830 0.176 4 0.529
DYRK4DYRK4 0.829 0.113 1 0.611
SIKSIK 0.829 0.001 -3 0.768
NUAK1NUAK1 0.829 -0.033 -3 0.790
VRK2VRK2 0.829 -0.044 1 0.859
CHAK1CHAK1 0.829 -0.077 2 0.767
CDK17CDK17 0.829 0.046 1 0.555
PHKG1PHKG1 0.829 -0.039 -3 0.836
PLK1PLK1 0.829 -0.078 -2 0.768
CDK14CDK14 0.829 0.077 1 0.660
MEK1MEK1 0.829 -0.111 2 0.834
MARK3MARK3 0.829 0.021 4 0.784
DRAK1DRAK1 0.828 0.010 1 0.786
P38GP38G 0.828 0.057 1 0.548
NEK2NEK2 0.828 -0.048 2 0.805
TTBK2TTBK2 0.828 -0.187 2 0.709
CAMK1GCAMK1G 0.827 0.012 -3 0.766
IRE2IRE2 0.827 -0.062 2 0.736
GSK3BGSK3B 0.827 0.139 4 0.522
CHK1CHK1 0.827 0.001 -3 0.828
BRSK1BRSK1 0.827 -0.038 -3 0.798
PRP4PRP4 0.827 0.116 -3 0.810
DYRK1ADYRK1A 0.827 0.075 1 0.718
CDK3CDK3 0.826 0.051 1 0.573
CDK2CDK2 0.826 -0.022 1 0.717
MLK4MLK4 0.825 -0.085 2 0.718
HIPK3HIPK3 0.825 0.087 1 0.699
GAKGAK 0.825 0.268 1 0.900
DYRK1BDYRK1B 0.825 0.085 1 0.651
AKT1AKT1 0.825 0.109 -3 0.715
P38DP38D 0.825 0.106 1 0.562
WNK4WNK4 0.825 0.005 -2 0.904
ERK2ERK2 0.825 0.013 1 0.677
MARK2MARK2 0.824 -0.011 4 0.749
BRSK2BRSK2 0.824 -0.067 -3 0.824
DYRK3DYRK3 0.824 0.107 1 0.706
TLK2TLK2 0.824 -0.038 1 0.776
ALK2ALK2 0.824 -0.009 -2 0.770
PLK3PLK3 0.823 -0.069 2 0.778
ACVR2AACVR2A 0.823 -0.027 -2 0.736
PAK5PAK5 0.823 0.092 -2 0.721
ACVR2BACVR2B 0.823 -0.024 -2 0.744
P70S6KP70S6K 0.822 0.043 -3 0.706
MAKMAK 0.822 0.185 -2 0.785
CDK16CDK16 0.822 0.062 1 0.574
PKCTPKCT 0.822 0.027 2 0.719
MAPKAPK5MAPKAPK5 0.822 -0.071 -3 0.717
TAO3TAO3 0.821 0.026 1 0.801
PLK4PLK4 0.821 -0.099 2 0.638
GRK2GRK2 0.821 -0.040 -2 0.679
CK1ECK1E 0.820 0.012 -3 0.604
ZAKZAK 0.820 -0.102 1 0.787
PKCIPKCI 0.820 0.039 2 0.737
SMMLCKSMMLCK 0.819 0.030 -3 0.822
MARK1MARK1 0.819 -0.045 4 0.799
NEK5NEK5 0.819 -0.004 1 0.839
PKCEPKCE 0.819 0.072 2 0.713
IRAK4IRAK4 0.819 -0.032 1 0.812
PAK4PAK4 0.819 0.093 -2 0.726
CAMK1DCAMK1D 0.818 0.045 -3 0.691
MEK5MEK5 0.818 -0.187 2 0.819
DCAMKL2DCAMKL2 0.818 -0.010 -3 0.816
MEKK1MEKK1 0.818 -0.104 1 0.805
BUB1BUB1 0.818 0.231 -5 0.818
LKB1LKB1 0.818 0.094 -3 0.845
SNRKSNRK 0.817 -0.181 2 0.671
MEKK3MEKK3 0.817 -0.161 1 0.809
GCKGCK 0.816 0.093 1 0.806
AKT3AKT3 0.816 0.106 -3 0.633
MEKK2MEKK2 0.816 -0.092 2 0.800
BRAFBRAF 0.816 -0.117 -4 0.839
SSTKSSTK 0.816 0.004 4 0.809
DAPK3DAPK3 0.815 0.099 -3 0.807
PERKPERK 0.815 -0.141 -2 0.807
CAMKK1CAMKK1 0.815 -0.028 -2 0.790
BMPR1ABMPR1A 0.814 0.020 1 0.754
PHKG2PHKG2 0.814 -0.044 -3 0.812
CAMKK2CAMKK2 0.813 0.024 -2 0.794
CK2A2CK2A2 0.813 0.088 1 0.670
HPK1HPK1 0.812 0.073 1 0.795
ROCK2ROCK2 0.812 0.144 -3 0.794
SGK1SGK1 0.812 0.095 -3 0.612
CK1DCK1D 0.811 0.018 -3 0.555
CK1A2CK1A2 0.811 0.023 -3 0.556
TNIKTNIK 0.811 0.080 3 0.774
PINK1PINK1 0.811 -0.166 1 0.827
MOKMOK 0.811 0.128 1 0.741
DAPK1DAPK1 0.811 0.087 -3 0.792
PBKPBK 0.811 0.221 1 0.838
NEK11NEK11 0.810 -0.117 1 0.792
MEKK6MEKK6 0.810 0.007 1 0.811
MRCKBMRCKB 0.810 0.101 -3 0.744
HRIHRI 0.810 -0.223 -2 0.814
ERK7ERK7 0.810 0.030 2 0.546
MRCKAMRCKA 0.809 0.095 -3 0.753
TAO2TAO2 0.809 -0.057 2 0.835
JNK1JNK1 0.809 0.027 1 0.598
KHS1KHS1 0.809 0.103 1 0.781
HGKHGK 0.809 0.020 3 0.774
CK1G1CK1G1 0.808 -0.027 -3 0.574
MINKMINK 0.808 0.018 1 0.800
CDK6CDK6 0.808 0.034 1 0.636
KHS2KHS2 0.807 0.101 1 0.796
TLK1TLK1 0.807 -0.176 -2 0.765
GRK3GRK3 0.807 -0.035 -2 0.630
MAP3K15MAP3K15 0.807 -0.026 1 0.773
NEK4NEK4 0.806 -0.056 1 0.800
CK2A1CK2A1 0.806 0.091 1 0.654
CDK4CDK4 0.806 0.028 1 0.601
LRRK2LRRK2 0.806 -0.036 2 0.841
PDK1PDK1 0.806 -0.068 1 0.778
DMPK1DMPK1 0.806 0.155 -3 0.768
NEK8NEK8 0.805 -0.155 2 0.810
LOKLOK 0.805 0.015 -2 0.791
CHK2CHK2 0.805 0.021 -3 0.644
SBKSBK 0.804 0.063 -3 0.576
PKN1PKN1 0.804 -0.017 -3 0.731
EEF2KEEF2K 0.803 -0.048 3 0.739
CAMK1ACAMK1A 0.803 0.033 -3 0.659
NEK1NEK1 0.803 0.003 1 0.812
MST2MST2 0.803 -0.081 1 0.806
STK33STK33 0.802 -0.103 2 0.627
IRAK1IRAK1 0.801 -0.250 -1 0.729
TAK1TAK1 0.801 -0.073 1 0.802
PLK2PLK2 0.801 -0.012 -3 0.781
SLKSLK 0.800 -0.035 -2 0.726
MST1MST1 0.800 -0.058 1 0.795
VRK1VRK1 0.799 -0.080 2 0.839
TTBK1TTBK1 0.799 -0.214 2 0.632
CRIKCRIK 0.798 0.112 -3 0.711
YSK1YSK1 0.798 -0.022 2 0.806
ROCK1ROCK1 0.796 0.101 -3 0.758
PDHK3_TYRPDHK3_TYR 0.795 0.286 4 0.886
PKG1PKG1 0.794 0.039 -2 0.656
BIKEBIKE 0.793 0.201 1 0.820
HASPINHASPIN 0.793 0.078 -1 0.774
OSR1OSR1 0.790 -0.027 2 0.802
MYO3BMYO3B 0.789 0.039 2 0.812
MEK2MEK2 0.789 -0.216 2 0.803
PDHK4_TYRPDHK4_TYR 0.788 0.156 2 0.883
YANK3YANK3 0.788 -0.030 2 0.424
TESK1_TYRTESK1_TYR 0.786 0.053 3 0.812
RIPK2RIPK2 0.786 -0.289 1 0.735
NEK3NEK3 0.785 -0.103 1 0.764
MAP2K4_TYRMAP2K4_TYR 0.785 0.092 -1 0.855
PKMYT1_TYRPKMYT1_TYR 0.784 0.091 3 0.777
MAP2K6_TYRMAP2K6_TYR 0.784 0.077 -1 0.860
LIMK2_TYRLIMK2_TYR 0.784 0.129 -3 0.896
ASK1ASK1 0.783 -0.085 1 0.760
BMPR2_TYRBMPR2_TYR 0.783 0.063 -1 0.852
AAK1AAK1 0.782 0.249 1 0.739
TTKTTK 0.782 -0.079 -2 0.779
MAP2K7_TYRMAP2K7_TYR 0.781 -0.071 2 0.858
TAO1TAO1 0.779 -0.078 1 0.728
MYO3AMYO3A 0.778 -0.077 1 0.781
PINK1_TYRPINK1_TYR 0.776 -0.127 1 0.834
PDHK1_TYRPDHK1_TYR 0.776 -0.057 -1 0.852
CK1ACK1A 0.775 -0.011 -3 0.461
LIMK1_TYRLIMK1_TYR 0.771 -0.109 2 0.842
EPHA6EPHA6 0.770 -0.009 -1 0.802
RETRET 0.769 -0.109 1 0.804
ALPHAK3ALPHAK3 0.767 -0.138 -1 0.752
EPHB4EPHB4 0.767 -0.015 -1 0.767
ABL2ABL2 0.767 0.054 -1 0.749
FGRFGR 0.767 -0.003 1 0.877
STLK3STLK3 0.765 -0.188 1 0.751
DDR1DDR1 0.765 -0.146 4 0.817
ABL1ABL1 0.764 0.044 -1 0.736
MST1RMST1R 0.764 -0.161 3 0.706
TNK2TNK2 0.763 -0.012 3 0.649
TYK2TYK2 0.763 -0.213 1 0.798
TYRO3TYRO3 0.763 -0.149 3 0.686
TXKTXK 0.762 0.032 1 0.821
CSF1RCSF1R 0.762 -0.125 3 0.683
JAK2JAK2 0.762 -0.166 1 0.793
NEK10_TYRNEK10_TYR 0.761 -0.043 1 0.700
ROS1ROS1 0.761 -0.167 3 0.641
YES1YES1 0.761 -0.053 -1 0.773
TNK1TNK1 0.761 -0.013 3 0.676
JAK3JAK3 0.759 -0.158 1 0.787
TNNI3K_TYRTNNI3K_TYR 0.759 -0.014 1 0.799
ITKITK 0.759 -0.041 -1 0.730
EPHA4EPHA4 0.758 -0.065 2 0.780
FERFER 0.757 -0.165 1 0.843
LCKLCK 0.755 -0.006 -1 0.757
KDRKDR 0.754 -0.148 3 0.645
HCKHCK 0.754 -0.101 -1 0.756
INSRRINSRR 0.753 -0.197 3 0.632
FGFR2FGFR2 0.753 -0.212 3 0.703
KITKIT 0.753 -0.170 3 0.697
SRMSSRMS 0.752 -0.129 1 0.829
YANK2YANK2 0.752 -0.071 2 0.433
BLKBLK 0.751 -0.008 -1 0.758
EPHB3EPHB3 0.751 -0.110 -1 0.740
PDGFRBPDGFRB 0.751 -0.230 3 0.692
WEE1_TYRWEE1_TYR 0.751 -0.105 -1 0.726
MERTKMERTK 0.751 -0.094 3 0.678
EPHB1EPHB1 0.751 -0.156 1 0.824
METMET 0.750 -0.127 3 0.687
FYNFYN 0.750 0.002 -1 0.741
AXLAXL 0.750 -0.160 3 0.670
EPHB2EPHB2 0.750 -0.104 -1 0.730
JAK1JAK1 0.749 -0.135 1 0.744
BMXBMX 0.749 -0.073 -1 0.674
FLT3FLT3 0.748 -0.228 3 0.689
DDR2DDR2 0.748 -0.047 3 0.619
FLT1FLT1 0.746 -0.154 -1 0.777
CK1G3CK1G3 0.746 -0.054 -3 0.412
EPHA3EPHA3 0.745 -0.141 2 0.753
TEKTEK 0.745 -0.260 3 0.624
FGFR1FGFR1 0.745 -0.264 3 0.654
TECTEC 0.744 -0.153 -1 0.664
BTKBTK 0.743 -0.236 -1 0.698
EPHA7EPHA7 0.743 -0.133 2 0.776
PTK2BPTK2B 0.742 -0.053 -1 0.692
PTK6PTK6 0.741 -0.233 -1 0.662
LTKLTK 0.741 -0.195 3 0.629
PDGFRAPDGFRA 0.741 -0.315 3 0.683
FGFR3FGFR3 0.741 -0.229 3 0.670
EPHA1EPHA1 0.741 -0.153 3 0.658
ERBB2ERBB2 0.740 -0.229 1 0.765
NTRK1NTRK1 0.740 -0.271 -1 0.766
PTK2PTK2 0.739 0.008 -1 0.753
ALKALK 0.739 -0.243 3 0.596
SRCSRC 0.739 -0.084 -1 0.727
LYNLYN 0.738 -0.134 3 0.621
FRKFRK 0.737 -0.182 -1 0.756
INSRINSR 0.736 -0.241 3 0.609
FLT4FLT4 0.736 -0.275 3 0.652
NTRK3NTRK3 0.736 -0.192 -1 0.723
NTRK2NTRK2 0.736 -0.290 3 0.649
EPHA5EPHA5 0.735 -0.130 2 0.761
MATKMATK 0.735 -0.162 -1 0.682
CSKCSK 0.734 -0.175 2 0.779
EPHA8EPHA8 0.733 -0.140 -1 0.730
SYKSYK 0.733 -0.038 -1 0.732
EGFREGFR 0.732 -0.146 1 0.682
CK1G2CK1G2 0.729 -0.062 -3 0.500
FGFR4FGFR4 0.727 -0.175 -1 0.702
EPHA2EPHA2 0.725 -0.135 -1 0.709
MUSKMUSK 0.723 -0.189 1 0.687
IGF1RIGF1R 0.722 -0.222 3 0.563
ERBB4ERBB4 0.720 -0.127 1 0.695
ZAP70ZAP70 0.717 -0.033 -1 0.688
FESFES 0.707 -0.208 -1 0.641