Motif 530 (n=169)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A024R4G9 | C19orf48 | S20 | psp | Chromosome 19 open reading frame 48 (Multidrug resistance-related protein, isoform CRA_a) | None |
A0A087WZ62 | None | S250 | ochoa | Mannosyltransferase (EC 2.4.1.-) | None |
A5PKW4 | PSD | S995 | ochoa | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) | Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}. |
O14497 | ARID1A | S1513 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
O14526 | FCHO1 | S622 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
O14578 | CIT | S1948 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
O15061 | SYNM | S1090 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15503 | INSIG1 | S125 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
O43310 | CTIF | S292 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
O43542 | XRCC3 | S225 | psp | DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3) | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}. |
O60271 | SPAG9 | S272 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
O60292 | SIPA1L3 | S1239 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60936 | NOL3 | S120 | ochoa | Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) | [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}. |
O75128 | COBL | S962 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
O75369 | FLNB | S1384 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75521 | ECI2 | S283 | ochoa | Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) | Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. {ECO:0000269|PubMed:10419495}. |
O75676 | RPS6KA4 | S721 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
O75691 | UTP20 | S1734 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
O76003 | GLRX3 | S118 | ochoa | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
O94992 | HEXIM1 | S66 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
O95359 | TACC2 | S245 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
P04040 | CAT | S167 | psp | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
P06127 | CD5 | S439 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
P11137 | MAP2 | S1588 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P13796 | LCP1 | S406 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
P13861 | PRKAR2A | S58 | ochoa | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
P16104 | H2AX | S122 | ochoa | Histone H2AX (H2a/x) (Histone H2A.X) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}. |
P20810 | CAST | S414 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
P22674 | CCNO | S81 | ochoa|psp | Cyclin-O | Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}. |
P27987 | ITPKB | S29 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
P31645 | SLC6A4 | S48 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
P35269 | GTF2F1 | S433 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
P35670 | ATP7B | S341 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
P43119 | PTGIR | S328 | psp | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
P46087 | NOP2 | S599 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
P48634 | PRRC2A | S908 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
P50402 | EMD | S120 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
P50570 | DNM2 | S742 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P50747 | HLCS | S124 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
P51617 | IRAK1 | S601 | ochoa | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
P55201 | BRPF1 | S844 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
P78356 | PIP4K2B | S319 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}. |
P78524 | DENND2B | S357 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
P78527 | PRKDC | S2056 | psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
Q00872 | MYBPC1 | S162 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
Q07157 | TJP1 | S1180 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q07157 | TJP1 | S1433 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q08050 | FOXM1 | S613 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
Q12774 | ARHGEF5 | S627 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
Q12906 | ILF3 | S190 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
Q13164 | MAPK7 | S720 | ochoa|psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Q13263 | TRIM28 | S417 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13370 | PDE3B | S554 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
Q13469 | NFATC2 | S53 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q13469 | NFATC2 | S704 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q14204 | DYNC1H1 | S3917 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
Q14469 | HES1 | S20 | ochoa | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}. |
Q14694 | USP10 | S27 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
Q15014 | MORF4L2 | S90 | ochoa | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
Q15678 | PTPN14 | S438 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
Q15942 | ZYX | S205 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
Q16799 | RTN1 | S335 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
Q16891 | IMMT | S583 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
Q2KJY2 | KIF26B | S1004 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
Q2LD37 | BLTP1 | S1361 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q3KQU3 | MAP7D1 | S809 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q52LW3 | ARHGAP29 | S1143 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
Q53T59 | HS1BP3 | S289 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
Q5JPB2 | ZNF831 | S918 | ochoa | Zinc finger protein 831 | None |
Q5SW79 | CEP170 | S239 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5SW79 | CEP170 | S1132 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5SW79 | CEP170 | S1384 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5VT52 | RPRD2 | S356 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q63ZY3 | KANK2 | S172 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q6N021 | TET2 | S936 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
Q6W2J9 | BCOR | S389 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
Q6ZUJ8 | PIK3AP1 | S573 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
Q717R9 | CYS1 | S128 | ochoa | Cystin-1 (Cilia-associated protein) | None |
Q7RTP6 | MICAL3 | S1346 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q7Z2K8 | GPRIN1 | S870 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z401 | DENND4A | S1606 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q7Z434 | MAVS | S285 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
Q86TI0 | TBC1D1 | S209 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
Q86YS3 | RAB11FIP4 | S253 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
Q8IVT5 | KSR1 | S267 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
Q8IWE2 | FAM114A1 | S40 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
Q8IWY9 | CDAN1 | S285 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
Q8IY92 | SLX4 | S956 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
Q8IY92 | SLX4 | S1631 | psp | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
Q8N122 | RPTOR | S606 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
Q8N201 | INTS1 | S19 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
Q8N3F8 | MICALL1 | S588 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8N680 | ZBTB2 | S491 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
Q8NCN4 | RNF169 | S471 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
Q8NF91 | SYNE1 | S8277 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
Q8NF91 | SYNE1 | S8688 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
Q8NHV4 | NEDD1 | S548 | ochoa | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
Q8TEH3 | DENND1A | S554 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
Q8TEJ3 | SH3RF3 | S438 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
Q8TEW8 | PARD3B | S140 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
Q8WUF5 | PPP1R13L | S225 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
Q8WWI1 | LMO7 | S322 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q8WXE0 | CASKIN2 | S825 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WYL5 | SSH1 | S834 | ochoa|psp | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
Q92508 | PIEZO1 | S393 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
Q96F63 | CCDC97 | S29 | ochoa | Coiled-coil domain-containing protein 97 | May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}. |
Q96HP0 | DOCK6 | S1230 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
Q96L14 | CEP170P1 | S93 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
Q96PL5 | ERMAP | S421 | ochoa | Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen) | Possible role as a cell-adhesion or receptor molecule of erythroid cells. |
Q96QB1 | DLC1 | S599 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
Q96RT1 | ERBIN | S1112 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
Q99459 | CDC5L | S293 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
Q99706 | KIR2DL4 | S81 | ochoa | Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}. |
Q9BRR9 | ARHGAP9 | S279 | ochoa | Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}. |
Q9BT88 | SYT11 | S144 | ochoa | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) | Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:27278822}. |
Q9BU70 | TRMO | S214 | ochoa | tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) | S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity). {ECO:0000250|UniProtKB:P28634, ECO:0000269|PubMed:25063302}. |
Q9BUF5 | TUBB6 | S56 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
Q9BVG9 | PTDSS2 | S24 | ochoa | Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:Q9Z1X2, ECO:0000269|PubMed:19014349}. |
Q9BVV6 | KIAA0586 | S321 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
Q9BYV9 | BACH2 | S315 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
Q9BZL4 | PPP1R12C | S327 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9BZL6 | PRKD2 | S375 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
Q9C0C2 | TNKS1BP1 | S976 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C2 | TNKS1BP1 | S1371 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C2 | TNKS1BP1 | S1418 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C2 | TNKS1BP1 | S1506 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H0E3 | SAP130 | S442 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
Q9H0J9 | PARP12 | S633 | ochoa | Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}. |
Q9H334 | FOXP1 | S37 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
Q9H4E7 | DEF6 | S568 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
Q9H4L7 | SMARCAD1 | S67 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
Q9H792 | PEAK1 | S1148 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9HCD5 | NCOA5 | S378 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
Q9HCD5 | NCOA5 | S416 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
Q9NQ25 | SLAMF7 | S305 | ochoa | SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation. |
Q9NR48 | ASH1L | S882 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
Q9NRH2 | SNRK | S383 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
Q9NZ09 | UBAP1 | S250 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
Q9NZJ0 | DTL | S425 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
Q9UDT6 | CLIP2 | S173 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
Q9UIS9 | MBD1 | S518 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
Q9UKJ3 | GPATCH8 | S738 | ochoa | G patch domain-containing protein 8 | None |
Q9UL51 | HCN2 | S80 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
Q9ULI0 | ATAD2B | S140 | ochoa | ATPase family AAA domain-containing protein 2B | None |
Q9UMS6 | SYNPO2 | S226 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UN30 | SCML1 | S176 | ochoa | Sex comb on midleg-like protein 1 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}. |
Q9UPN3 | MACF1 | S6969 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
Q9UPN4 | CEP131 | S146 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
Q9UQP3 | TNN | S937 | ochoa | Tenascin-N (TN-N) (Tenascin-W) (TN-W) | Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}. |
Q9UQR1 | ZNF148 | S727 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
Q9Y3Q8 | TSC22D4 | S225 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
Q9Y3S1 | WNK2 | S1846 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Q9Y4G8 | RAPGEF2 | S498 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
Q9Y520 | PRRC2C | S375 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
Q9Y6D6 | ARFGEF1 | S1580 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
Q9Y696 | CLIC4 | S31 | Sugiyama | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
O14965 | AURKA | S98 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
O15111 | CHUK | S414 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
P29401 | TKT | S443 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
Q6IBS0 | TWF2 | S139 | Sugiyama | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
P21333 | FLNA | S732 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P13674 | P4HA1 | S387 | Sugiyama | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
O95071 | UBR5 | S2384 | Sugiyama | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
O15372 | EIF3H | S302 | Sugiyama | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
P78406 | RAE1 | S74 | Sugiyama | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | Acts as a mRNA export factor involved in nucleocytoplasmic transport (PubMed:20498086, PubMed:33849972). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455). {ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:20498086, ECO:0000269|PubMed:33849972}. |
O94842 | TOX4 | S575 | Sugiyama | TOX high mobility group box family member 4 | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}. |
Q96EP5 | DAZAP1 | S193 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
Q6GYQ0 | RALGAPA1 | S1280 | Sugiyama | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q9Y6M4 | CSNK1G3 | S372 | Sugiyama | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-5602636 | IKBKB deficiency causes SCID | 0.033341 | 1.477 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.033341 | 1.477 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.044208 | 1.355 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.044208 | 1.355 |
R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.044208 | 1.355 |
R-HSA-198765 | Signalling to ERK5 | 0.044208 | 1.355 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.044208 | 1.355 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.044208 | 1.355 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.044208 | 1.355 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.044208 | 1.355 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.044208 | 1.355 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.044208 | 1.355 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.044208 | 1.355 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.044208 | 1.355 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.044208 | 1.355 |
R-HSA-1296061 | HCN channels | 0.065577 | 1.183 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.011224 | 1.950 |
R-HSA-937039 | IRAK1 recruits IKK complex | 0.014446 | 1.840 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.014446 | 1.840 |
R-HSA-109703 | PKB-mediated events | 0.086471 | 1.063 |
R-HSA-165160 | PDE3B signalling | 0.086471 | 1.063 |
R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.106901 | 0.971 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.001647 | 2.783 |
R-HSA-202670 | ERKs are inactivated | 0.156008 | 0.807 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.008988 | 2.046 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.008988 | 2.046 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.005186 | 2.285 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.013969 | 1.855 |
R-HSA-380287 | Centrosome maturation | 0.015138 | 1.820 |
R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.237731 | 0.624 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.237731 | 0.624 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.246311 | 0.609 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.125094 | 0.903 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.132642 | 0.877 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.271479 | 0.566 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.279681 | 0.553 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.279681 | 0.553 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.279681 | 0.553 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.148034 | 0.830 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.287791 | 0.541 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.151937 | 0.818 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.295810 | 0.529 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.311580 | 0.506 |
R-HSA-171306 | Packaging Of Telomere Ends | 0.311580 | 0.506 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.311580 | 0.506 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.179775 | 0.745 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.319333 | 0.496 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.319333 | 0.496 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.319333 | 0.496 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.319333 | 0.496 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.220677 | 0.656 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.287252 | 0.542 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.287252 | 0.542 |
R-HSA-209543 | p75NTR recruits signalling complexes | 0.014446 | 1.840 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.026720 | 1.573 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.137078 | 0.863 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.093806 | 1.028 |
R-HSA-156711 | Polo-like kinase mediated events | 0.229054 | 0.640 |
R-HSA-193639 | p75NTR signals via NF-kB | 0.019927 | 1.701 |
R-HSA-191650 | Regulation of gap junction activity | 0.065577 | 1.183 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.106901 | 0.971 |
R-HSA-190873 | Gap junction degradation | 0.126876 | 0.897 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.045853 | 1.339 |
R-HSA-163615 | PKA activation | 0.229054 | 0.640 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.311580 | 0.506 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.246311 | 0.609 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.061244 | 1.213 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.224815 | 0.648 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.075843 | 1.120 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.008368 | 2.077 |
R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.106901 | 0.971 |
R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.126876 | 0.897 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.072618 | 1.139 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.246311 | 0.609 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.078805 | 1.103 |
R-HSA-1221632 | Meiotic synapsis | 0.151937 | 0.818 |
R-HSA-9609690 | HCMV Early Events | 0.036436 | 1.438 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.271359 | 0.566 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.253911 | 0.595 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.194060 | 0.712 |
R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.136696 | 0.864 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.184174 | 0.735 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.193353 | 0.714 |
R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.211405 | 0.675 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.245581 | 0.610 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.128855 | 0.890 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.014446 | 1.840 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.103142 | 0.987 |
R-HSA-198753 | ERK/MAPK targets | 0.254795 | 0.594 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.274403 | 0.562 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.202430 | 0.694 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.211405 | 0.675 |
R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.054952 | 1.260 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.065577 | 1.183 |
R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.076083 | 1.119 |
R-HSA-1483101 | Synthesis of PS | 0.086471 | 1.063 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.086471 | 1.063 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.021919 | 1.659 |
R-HSA-196025 | Formation of annular gap junctions | 0.116944 | 0.932 |
R-HSA-177135 | Conjugation of benzoate with glycine | 0.146407 | 0.834 |
R-HSA-209560 | NF-kB is activated and signals survival | 0.156008 | 0.807 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.165503 | 0.781 |
R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.165503 | 0.781 |
R-HSA-177128 | Conjugation of salicylate with glycine | 0.165503 | 0.781 |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.174891 | 0.757 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.193353 | 0.714 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.072618 | 1.139 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.220279 | 0.657 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.229054 | 0.640 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.237731 | 0.624 |
R-HSA-5620924 | Intraflagellar transport | 0.132642 | 0.877 |
R-HSA-8949613 | Cristae formation | 0.311580 | 0.506 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.311580 | 0.506 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.183815 | 0.736 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.208305 | 0.681 |
R-HSA-1500620 | Meiosis | 0.283088 | 0.548 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.129942 | 0.886 |
R-HSA-162587 | HIV Life Cycle | 0.317304 | 0.499 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.254795 | 0.594 |
R-HSA-9609646 | HCMV Infection | 0.034862 | 1.458 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.158150 | 0.801 |
R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.184174 | 0.735 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.295810 | 0.529 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.295810 | 0.529 |
R-HSA-5617833 | Cilium Assembly | 0.032450 | 1.489 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.126933 | 0.896 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.228959 | 0.640 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.158150 | 0.801 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.126933 | 0.896 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.126933 | 0.896 |
R-HSA-69275 | G2/M Transition | 0.009223 | 2.035 |
R-HSA-196780 | Biotin transport and metabolism | 0.193353 | 0.714 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.155463 | 0.808 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.009690 | 2.014 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.169041 | 0.772 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.174891 | 0.757 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.027448 | 1.561 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.177348 | 0.751 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.191436 | 0.718 |
R-HSA-68877 | Mitotic Prometaphase | 0.094044 | 1.027 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.191436 | 0.718 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.200022 | 0.699 |
R-HSA-525793 | Myogenesis | 0.303740 | 0.517 |
R-HSA-68875 | Mitotic Prophase | 0.194287 | 0.712 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.200022 | 0.699 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003831 | 2.417 |
R-HSA-9729555 | Sensory perception of sour taste | 0.065577 | 1.183 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.018016 | 1.744 |
R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.106901 | 0.971 |
R-HSA-9646399 | Aggrephagy | 0.016687 | 1.778 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.174891 | 0.757 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.184174 | 0.735 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.004162 | 2.381 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.193353 | 0.714 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 0.229054 | 0.640 |
R-HSA-159424 | Conjugation of carboxylic acids | 0.237731 | 0.624 |
R-HSA-156587 | Amino Acid conjugation | 0.237731 | 0.624 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.237731 | 0.624 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.059420 | 1.226 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.254795 | 0.594 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.287791 | 0.541 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.319333 | 0.496 |
R-HSA-446652 | Interleukin-1 family signaling | 0.127981 | 0.893 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.287791 | 0.541 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.167743 | 0.775 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.197149 | 0.705 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.019927 | 1.701 |
R-HSA-190828 | Gap junction trafficking | 0.117655 | 0.929 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.171797 | 0.765 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.004813 | 2.318 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.126876 | 0.897 |
R-HSA-437239 | Recycling pathway of L1 | 0.025061 | 1.601 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.035309 | 1.452 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.091595 | 1.038 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.202904 | 0.693 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.229054 | 0.640 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.233108 | 0.632 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.120267 | 0.920 |
R-HSA-9610379 | HCMV Late Events | 0.317304 | 0.499 |
R-HSA-68886 | M Phase | 0.088535 | 1.053 |
R-HSA-5693538 | Homology Directed Repair | 0.188595 | 0.724 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.012790 | 1.893 |
R-HSA-389542 | NADPH regeneration | 0.096743 | 1.014 |
R-HSA-1462054 | Alpha-defensins | 0.116944 | 0.932 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.184174 | 0.735 |
R-HSA-450294 | MAP kinase activation | 0.044204 | 1.355 |
R-HSA-166208 | mTORC1-mediated signalling | 0.271479 | 0.566 |
R-HSA-429947 | Deadenylation of mRNA | 0.287791 | 0.541 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.191934 | 0.717 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.160852 | 0.794 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.092731 | 1.033 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.160852 | 0.794 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.147490 | 0.831 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.202904 | 0.693 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.214891 | 0.668 |
R-HSA-199991 | Membrane Trafficking | 0.041420 | 1.383 |
R-HSA-448424 | Interleukin-17 signaling | 0.059420 | 1.226 |
R-HSA-1474165 | Reproduction | 0.084987 | 1.071 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.014446 | 1.840 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.121968 | 0.914 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.088254 | 1.054 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.129443 | 0.888 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.147819 | 0.830 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.109091 | 0.962 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.224815 | 0.648 |
R-HSA-5653656 | Vesicle-mediated transport | 0.147032 | 0.833 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.193353 | 0.714 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.263184 | 0.580 |
R-HSA-3214847 | HATs acetylate histones | 0.037086 | 1.431 |
R-HSA-200425 | Carnitine shuttle | 0.279681 | 0.553 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.311580 | 0.506 |
R-HSA-4839726 | Chromatin organization | 0.034280 | 1.465 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.226293 | 0.645 |
R-HSA-73894 | DNA Repair | 0.261067 | 0.583 |
R-HSA-2132295 | MHC class II antigen presentation | 0.071047 | 1.148 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.229054 | 0.640 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.117655 | 0.929 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.151328 | 0.820 |
R-HSA-1640170 | Cell Cycle | 0.204223 | 0.690 |
R-HSA-9833482 | PKR-mediated signaling | 0.018326 | 1.737 |
R-HSA-9007101 | Rab regulation of trafficking | 0.185766 | 0.731 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.130461 | 0.885 |
R-HSA-74160 | Gene expression (Transcription) | 0.091147 | 1.040 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.086471 | 1.063 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.220279 | 0.657 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.229054 | 0.640 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.136455 | 0.865 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.287791 | 0.541 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.121968 | 0.914 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.139931 | 0.854 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.026320 | 1.580 |
R-HSA-9609507 | Protein localization | 0.305010 | 0.516 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.174891 | 0.757 |
R-HSA-1632852 | Macroautophagy | 0.105475 | 0.977 |
R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.116944 | 0.932 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.136696 | 0.864 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.263184 | 0.580 |
R-HSA-983189 | Kinesins | 0.179775 | 0.745 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.003667 | 2.436 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.063226 | 1.199 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.270586 | 0.568 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.082426 | 1.084 |
R-HSA-9612973 | Autophagy | 0.048726 | 1.312 |
R-HSA-73887 | Death Receptor Signaling | 0.131915 | 0.880 |
R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.229054 | 0.640 |
R-HSA-175474 | Assembly Of The HIV Virion | 0.263184 | 0.580 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.241420 | 0.617 |
R-HSA-68882 | Mitotic Anaphase | 0.278173 | 0.556 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.155323 | 0.809 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.280672 | 0.552 |
R-HSA-73893 | DNA Damage Bypass | 0.136455 | 0.865 |
R-HSA-9033241 | Peroxisomal protein import | 0.175750 | 0.755 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.111862 | 0.951 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.126876 | 0.897 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.035456 | 1.450 |
R-HSA-391908 | Prostanoid ligand receptors | 0.146407 | 0.834 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.165503 | 0.781 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.237731 | 0.624 |
R-HSA-9827857 | Specification of primordial germ cells | 0.026137 | 1.583 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.228959 | 0.640 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.116944 | 0.932 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.174891 | 0.757 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.142252 | 0.847 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.262247 | 0.581 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.179775 | 0.745 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.179775 | 0.745 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.179775 | 0.745 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.179775 | 0.745 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.178236 | 0.749 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.144010 | 0.842 |
R-HSA-1980145 | Signaling by NOTCH2 | 0.079113 | 1.102 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.211405 | 0.675 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.237731 | 0.624 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.287791 | 0.541 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.287791 | 0.541 |
R-HSA-9663891 | Selective autophagy | 0.098294 | 1.007 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.220677 | 0.656 |
R-HSA-913531 | Interferon Signaling | 0.175108 | 0.757 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.311580 | 0.506 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.262247 | 0.581 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.236363 | 0.626 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.171797 | 0.765 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.159803 | 0.796 |
R-HSA-9645723 | Diseases of programmed cell death | 0.299728 | 0.523 |
R-HSA-446728 | Cell junction organization | 0.123548 | 0.908 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.220677 | 0.656 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.226754 | 0.644 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.051421 | 1.289 |
R-HSA-186712 | Regulation of beta-cell development | 0.175750 | 0.755 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.245581 | 0.610 |
R-HSA-438064 | Post NMDA receptor activation events | 0.295573 | 0.529 |
R-HSA-373760 | L1CAM interactions | 0.182948 | 0.738 |
R-HSA-9008059 | Interleukin-37 signaling | 0.063226 | 1.199 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.271479 | 0.566 |
R-HSA-418990 | Adherens junctions interactions | 0.283175 | 0.548 |
R-HSA-1500931 | Cell-Cell communication | 0.182197 | 0.739 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.227649 | 0.643 |
R-HSA-8983711 | OAS antiviral response | 0.165503 | 0.781 |
R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.246311 | 0.609 |
R-HSA-212436 | Generic Transcription Pathway | 0.121208 | 0.916 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.106722 | 0.972 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.311604 | 0.506 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.285132 | 0.545 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.079113 | 1.102 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.279681 | 0.553 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.237731 | 0.624 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.027580 | 1.559 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.179775 | 0.745 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.286615 | 0.543 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.237262 | 0.625 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.054290 | 1.265 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.167743 | 0.775 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.055850 | 1.253 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.117655 | 0.929 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.319333 | 0.496 |
R-HSA-2028269 | Signaling by Hippo | 0.220279 | 0.657 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.200100 | 0.699 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.196011 | 0.708 |
R-HSA-9020591 | Interleukin-12 signaling | 0.245581 | 0.610 |
R-HSA-447115 | Interleukin-12 family signaling | 0.295573 | 0.529 |
R-HSA-5334118 | DNA methylation | 0.326999 | 0.485 |
R-HSA-72086 | mRNA Capping | 0.326999 | 0.485 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.326999 | 0.485 |
R-HSA-9615710 | Late endosomal microautophagy | 0.326999 | 0.485 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.326999 | 0.485 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.326999 | 0.485 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.326999 | 0.485 |
R-HSA-180024 | DARPP-32 events | 0.326999 | 0.485 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.326999 | 0.485 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.332794 | 0.478 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.334580 | 0.476 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.334580 | 0.476 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.334580 | 0.476 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.334580 | 0.476 |
R-HSA-112311 | Neurotransmitter clearance | 0.334580 | 0.476 |
R-HSA-114452 | Activation of BH3-only proteins | 0.334580 | 0.476 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.338835 | 0.470 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.340997 | 0.467 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.342075 | 0.466 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.342075 | 0.466 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.342075 | 0.466 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.342075 | 0.466 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.342075 | 0.466 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.342075 | 0.466 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.345087 | 0.462 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.349486 | 0.457 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.349486 | 0.457 |
R-HSA-9614085 | FOXO-mediated transcription | 0.353242 | 0.452 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.356814 | 0.448 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.356814 | 0.448 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.356814 | 0.448 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.356814 | 0.448 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.356814 | 0.448 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.356814 | 0.448 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.356814 | 0.448 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.356814 | 0.448 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.357307 | 0.447 |
R-HSA-70171 | Glycolysis | 0.357307 | 0.447 |
R-HSA-5610787 | Hedgehog 'off' state | 0.357307 | 0.447 |
R-HSA-9020702 | Interleukin-1 signaling | 0.361362 | 0.442 |
R-HSA-418555 | G alpha (s) signalling events | 0.363391 | 0.440 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.363391 | 0.440 |
R-HSA-390522 | Striated Muscle Contraction | 0.364061 | 0.439 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.364061 | 0.439 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.364061 | 0.439 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.364061 | 0.439 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.365408 | 0.437 |
R-HSA-421270 | Cell-cell junction organization | 0.366974 | 0.435 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.369512 | 0.432 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.369512 | 0.432 |
R-HSA-5673000 | RAF activation | 0.371226 | 0.430 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.371226 | 0.430 |
R-HSA-180746 | Nuclear import of Rev protein | 0.371226 | 0.430 |
R-HSA-190861 | Gap junction assembly | 0.371226 | 0.430 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.371226 | 0.430 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.373471 | 0.428 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.378310 | 0.422 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.378310 | 0.422 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.378310 | 0.422 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.385316 | 0.414 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.385316 | 0.414 |
R-HSA-111933 | Calmodulin induced events | 0.385316 | 0.414 |
R-HSA-111997 | CaM pathway | 0.385316 | 0.414 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 0.385316 | 0.414 |
R-HSA-8853659 | RET signaling | 0.385316 | 0.414 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.385316 | 0.414 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.389471 | 0.410 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.389471 | 0.410 |
R-HSA-211000 | Gene Silencing by RNA | 0.389471 | 0.410 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.392242 | 0.406 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.392242 | 0.406 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.392242 | 0.406 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.392242 | 0.406 |
R-HSA-110331 | Cleavage of the damaged purine | 0.392242 | 0.406 |
R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.392242 | 0.406 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.392242 | 0.406 |
R-HSA-73927 | Depurination | 0.399092 | 0.399 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.399092 | 0.399 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.399092 | 0.399 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.399092 | 0.399 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.399092 | 0.399 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.404818 | 0.393 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.405864 | 0.392 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.405864 | 0.392 |
R-HSA-71336 | Pentose phosphate pathway | 0.405864 | 0.392 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.405864 | 0.392 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.409213 | 0.388 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.412561 | 0.385 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.412561 | 0.385 |
R-HSA-167169 | HIV Transcription Elongation | 0.412561 | 0.385 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.412561 | 0.385 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.412561 | 0.385 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.412561 | 0.385 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.412561 | 0.385 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.412561 | 0.385 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.412561 | 0.385 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.412561 | 0.385 |
R-HSA-5260271 | Diseases of Immune System | 0.412561 | 0.385 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.419182 | 0.378 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.419182 | 0.378 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.419182 | 0.378 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.419182 | 0.378 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.419182 | 0.378 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.419182 | 0.378 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.425729 | 0.371 |
R-HSA-167161 | HIV Transcription Initiation | 0.425729 | 0.371 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.425729 | 0.371 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.425729 | 0.371 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.425729 | 0.371 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.425729 | 0.371 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.425729 | 0.371 |
R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.425729 | 0.371 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.428641 | 0.368 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.432203 | 0.364 |
R-HSA-165159 | MTOR signalling | 0.432203 | 0.364 |
R-HSA-111996 | Ca-dependent events | 0.432203 | 0.364 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.432203 | 0.364 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.432203 | 0.364 |
R-HSA-73928 | Depyrimidination | 0.432203 | 0.364 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.432924 | 0.364 |
R-HSA-70326 | Glucose metabolism | 0.436319 | 0.360 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.437904 | 0.359 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.438604 | 0.358 |
R-HSA-9710421 | Defective pyroptosis | 0.438604 | 0.358 |
R-HSA-1461973 | Defensins | 0.438604 | 0.358 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.440138 | 0.356 |
R-HSA-8953897 | Cellular responses to stimuli | 0.447261 | 0.349 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.451192 | 0.346 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.451192 | 0.346 |
R-HSA-774815 | Nucleosome assembly | 0.451192 | 0.346 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.451192 | 0.346 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.451192 | 0.346 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.451192 | 0.346 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.451192 | 0.346 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.451192 | 0.346 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.451192 | 0.346 |
R-HSA-1489509 | DAG and IP3 signaling | 0.451192 | 0.346 |
R-HSA-3371556 | Cellular response to heat stress | 0.451507 | 0.345 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.451507 | 0.345 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.456503 | 0.341 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.457380 | 0.340 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.457380 | 0.340 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.457380 | 0.340 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.457380 | 0.340 |
R-HSA-6802949 | Signaling by RAS mutants | 0.457380 | 0.340 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.457380 | 0.340 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.457380 | 0.340 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.457380 | 0.340 |
R-HSA-75153 | Apoptotic execution phase | 0.457380 | 0.340 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.459423 | 0.338 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.463499 | 0.334 |
R-HSA-72172 | mRNA Splicing | 0.465241 | 0.332 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.468435 | 0.329 |
R-HSA-9634597 | GPER1 signaling | 0.469550 | 0.328 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.469550 | 0.328 |
R-HSA-9031628 | NGF-stimulated transcription | 0.469550 | 0.328 |
R-HSA-9766229 | Degradation of CDH1 | 0.475532 | 0.323 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.481175 | 0.318 |
R-HSA-109704 | PI3K Cascade | 0.481447 | 0.317 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.481447 | 0.317 |
R-HSA-912446 | Meiotic recombination | 0.487296 | 0.312 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.487296 | 0.312 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.487296 | 0.312 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.493079 | 0.307 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.493079 | 0.307 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.493079 | 0.307 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.498798 | 0.302 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.498798 | 0.302 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.498798 | 0.302 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.498798 | 0.302 |
R-HSA-72649 | Translation initiation complex formation | 0.504452 | 0.297 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.504452 | 0.297 |
R-HSA-3214815 | HDACs deacetylate histones | 0.510043 | 0.292 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.515571 | 0.288 |
R-HSA-193648 | NRAGE signals death through JNK | 0.515571 | 0.288 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.515571 | 0.288 |
R-HSA-75893 | TNF signaling | 0.515571 | 0.288 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.515571 | 0.288 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.515571 | 0.288 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.516849 | 0.287 |
R-HSA-163685 | Integration of energy metabolism | 0.516849 | 0.287 |
R-HSA-112399 | IRS-mediated signalling | 0.521037 | 0.283 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.521037 | 0.283 |
R-HSA-5358351 | Signaling by Hedgehog | 0.523788 | 0.281 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.526442 | 0.279 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.526442 | 0.279 |
R-HSA-162906 | HIV Infection | 0.530017 | 0.276 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.531786 | 0.274 |
R-HSA-191859 | snRNP Assembly | 0.531786 | 0.274 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.531786 | 0.274 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.531786 | 0.274 |
R-HSA-1227986 | Signaling by ERBB2 | 0.537070 | 0.270 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.537070 | 0.270 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.537070 | 0.270 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.537070 | 0.270 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.542295 | 0.266 |
R-HSA-112043 | PLC beta mediated events | 0.542295 | 0.266 |
R-HSA-445717 | Aquaporin-mediated transport | 0.542295 | 0.266 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.547461 | 0.262 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.547461 | 0.262 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.547461 | 0.262 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.547461 | 0.262 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.547461 | 0.262 |
R-HSA-1280218 | Adaptive Immune System | 0.549344 | 0.260 |
R-HSA-2428924 | IGF1R signaling cascade | 0.557620 | 0.254 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.557620 | 0.254 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.557620 | 0.254 |
R-HSA-166520 | Signaling by NTRKs | 0.560746 | 0.251 |
R-HSA-1474244 | Extracellular matrix organization | 0.562174 | 0.250 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.562614 | 0.250 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.562614 | 0.250 |
R-HSA-162582 | Signal Transduction | 0.564567 | 0.248 |
R-HSA-157118 | Signaling by NOTCH | 0.564657 | 0.248 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.567552 | 0.246 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.570466 | 0.244 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.572435 | 0.242 |
R-HSA-112040 | G-protein mediated events | 0.572435 | 0.242 |
R-HSA-167172 | Transcription of the HIV genome | 0.577262 | 0.239 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.577262 | 0.239 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.577262 | 0.239 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.577262 | 0.239 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.582036 | 0.235 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.583184 | 0.234 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.586756 | 0.232 |
R-HSA-3000178 | ECM proteoglycans | 0.591423 | 0.228 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.591423 | 0.228 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.591423 | 0.228 |
R-HSA-8978934 | Metabolism of cofactors | 0.591423 | 0.228 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.596037 | 0.225 |
R-HSA-449147 | Signaling by Interleukins | 0.597938 | 0.223 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.600600 | 0.221 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.600600 | 0.221 |
R-HSA-9749641 | Aspirin ADME | 0.600600 | 0.221 |
R-HSA-109581 | Apoptosis | 0.604773 | 0.218 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.605111 | 0.218 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.605111 | 0.218 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.605111 | 0.218 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.609572 | 0.215 |
R-HSA-8852135 | Protein ubiquitination | 0.609572 | 0.215 |
R-HSA-917937 | Iron uptake and transport | 0.609572 | 0.215 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.609572 | 0.215 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.609986 | 0.215 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.622656 | 0.206 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 0.622656 | 0.206 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.622656 | 0.206 |
R-HSA-9659379 | Sensory processing of sound | 0.626919 | 0.203 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.626919 | 0.203 |
R-HSA-6798695 | Neutrophil degranulation | 0.630469 | 0.200 |
R-HSA-5654738 | Signaling by FGFR2 | 0.631135 | 0.200 |
R-HSA-2262752 | Cellular responses to stress | 0.631652 | 0.200 |
R-HSA-9711123 | Cellular response to chemical stress | 0.633781 | 0.198 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.635303 | 0.197 |
R-HSA-977225 | Amyloid fiber formation | 0.635303 | 0.197 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.639425 | 0.194 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.643500 | 0.191 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.647529 | 0.189 |
R-HSA-390918 | Peroxisomal lipid metabolism | 0.647529 | 0.189 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.651513 | 0.186 |
R-HSA-9824446 | Viral Infection Pathways | 0.651781 | 0.186 |
R-HSA-168255 | Influenza Infection | 0.656388 | 0.183 |
R-HSA-2559583 | Cellular Senescence | 0.659092 | 0.181 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.659348 | 0.181 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.663199 | 0.178 |
R-HSA-168249 | Innate Immune System | 0.670203 | 0.174 |
R-HSA-1236974 | ER-Phagosome pathway | 0.670772 | 0.173 |
R-HSA-202424 | Downstream TCR signaling | 0.674494 | 0.171 |
R-HSA-73884 | Base Excision Repair | 0.674494 | 0.171 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.678175 | 0.169 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.680120 | 0.167 |
R-HSA-983712 | Ion channel transport | 0.682673 | 0.166 |
R-HSA-391251 | Protein folding | 0.685413 | 0.164 |
R-HSA-74752 | Signaling by Insulin receptor | 0.685413 | 0.164 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.688971 | 0.162 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.688971 | 0.162 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.692489 | 0.160 |
R-HSA-1474290 | Collagen formation | 0.692489 | 0.160 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.699407 | 0.155 |
R-HSA-1296071 | Potassium Channels | 0.702808 | 0.153 |
R-HSA-157579 | Telomere Maintenance | 0.706170 | 0.151 |
R-HSA-190236 | Signaling by FGFR | 0.709494 | 0.149 |
R-HSA-422356 | Regulation of insulin secretion | 0.709494 | 0.149 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.722423 | 0.141 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.722423 | 0.141 |
R-HSA-1483255 | PI Metabolism | 0.722423 | 0.141 |
R-HSA-5357801 | Programmed Cell Death | 0.723583 | 0.141 |
R-HSA-111885 | Opioid Signalling | 0.728670 | 0.137 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.731742 | 0.136 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.731742 | 0.136 |
R-HSA-9833110 | RSV-host interactions | 0.731742 | 0.136 |
R-HSA-418346 | Platelet homeostasis | 0.737781 | 0.132 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.737781 | 0.132 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.739097 | 0.131 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.743685 | 0.129 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.743685 | 0.129 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.743685 | 0.129 |
R-HSA-2672351 | Stimuli-sensing channels | 0.743685 | 0.129 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.746404 | 0.127 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.746587 | 0.127 |
R-HSA-202403 | TCR signaling | 0.749457 | 0.125 |
R-HSA-6803157 | Antimicrobial peptides | 0.752294 | 0.124 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.757873 | 0.120 |
R-HSA-8951664 | Neddylation | 0.757952 | 0.120 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.766008 | 0.116 |
R-HSA-422475 | Axon guidance | 0.769567 | 0.114 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.771279 | 0.113 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.771279 | 0.113 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.773719 | 0.111 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.773871 | 0.111 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.778966 | 0.108 |
R-HSA-72312 | rRNA processing | 0.779397 | 0.108 |
R-HSA-9679506 | SARS-CoV Infections | 0.782534 | 0.106 |
R-HSA-73886 | Chromosome Maintenance | 0.783948 | 0.106 |
R-HSA-168256 | Immune System | 0.784773 | 0.105 |
R-HSA-8939211 | ESR-mediated signaling | 0.788586 | 0.103 |
R-HSA-162909 | Host Interactions of HIV factors | 0.791211 | 0.102 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.795918 | 0.099 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.795918 | 0.099 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.795918 | 0.099 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.798231 | 0.098 |
R-HSA-114608 | Platelet degranulation | 0.800519 | 0.097 |
R-HSA-69481 | G2/M Checkpoints | 0.800519 | 0.097 |
R-HSA-112316 | Neuronal System | 0.805665 | 0.094 |
R-HSA-9717189 | Sensory perception of taste | 0.811576 | 0.091 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.813713 | 0.090 |
R-HSA-9675108 | Nervous system development | 0.814752 | 0.089 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.815826 | 0.088 |
R-HSA-5688426 | Deubiquitination | 0.818942 | 0.087 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.826039 | 0.083 |
R-HSA-6807070 | PTEN Regulation | 0.829964 | 0.081 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.841220 | 0.075 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.846948 | 0.072 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.851735 | 0.070 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.855083 | 0.068 |
R-HSA-8953854 | Metabolism of RNA | 0.855099 | 0.068 |
R-HSA-69306 | DNA Replication | 0.856729 | 0.067 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.858357 | 0.066 |
R-HSA-9711097 | Cellular response to starvation | 0.864684 | 0.063 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.865858 | 0.063 |
R-HSA-1483257 | Phospholipid metabolism | 0.872885 | 0.059 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.874023 | 0.058 |
R-HSA-5619102 | SLC transporter disorders | 0.877913 | 0.057 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.879418 | 0.056 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.883371 | 0.054 |
R-HSA-72306 | tRNA processing | 0.883371 | 0.054 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.886009 | 0.053 |
R-HSA-5689880 | Ub-specific processing proteases | 0.887305 | 0.052 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.887305 | 0.052 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.887305 | 0.052 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.889854 | 0.051 |
R-HSA-109582 | Hemostasis | 0.896171 | 0.048 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.899490 | 0.046 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.907254 | 0.042 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.917270 | 0.038 |
R-HSA-428157 | Sphingolipid metabolism | 0.918213 | 0.037 |
R-HSA-376176 | Signaling by ROBO receptors | 0.920066 | 0.036 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.920066 | 0.036 |
R-HSA-5683057 | MAPK family signaling cascades | 0.921032 | 0.036 |
R-HSA-397014 | Muscle contraction | 0.928724 | 0.032 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.929536 | 0.032 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.932007 | 0.031 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.932643 | 0.030 |
R-HSA-9748784 | Drug ADME | 0.933464 | 0.030 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.942024 | 0.026 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.944244 | 0.025 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.947717 | 0.023 |
R-HSA-388396 | GPCR downstream signalling | 0.948721 | 0.023 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.951211 | 0.022 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.952308 | 0.021 |
R-HSA-8978868 | Fatty acid metabolism | 0.955673 | 0.020 |
R-HSA-5663205 | Infectious disease | 0.956783 | 0.019 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.956996 | 0.019 |
R-HSA-9734767 | Developmental Cell Lineages | 0.960323 | 0.018 |
R-HSA-416476 | G alpha (q) signalling events | 0.960776 | 0.017 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.965041 | 0.015 |
R-HSA-9658195 | Leishmania infection | 0.967748 | 0.014 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.967748 | 0.014 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.968117 | 0.014 |
R-HSA-597592 | Post-translational protein modification | 0.971858 | 0.012 |
R-HSA-372790 | Signaling by GPCR | 0.972426 | 0.012 |
R-HSA-382551 | Transport of small molecules | 0.972788 | 0.012 |
R-HSA-195721 | Signaling by WNT | 0.973486 | 0.012 |
R-HSA-1643685 | Disease | 0.974914 | 0.011 |
R-HSA-8957322 | Metabolism of steroids | 0.980358 | 0.009 |
R-HSA-1266738 | Developmental Biology | 0.981386 | 0.008 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.983861 | 0.007 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.991365 | 0.004 |
R-HSA-418594 | G alpha (i) signalling events | 0.992574 | 0.003 |
R-HSA-5668914 | Diseases of metabolism | 0.994114 | 0.003 |
R-HSA-72766 | Translation | 0.994249 | 0.003 |
R-HSA-211859 | Biological oxidations | 0.998079 | 0.001 |
R-HSA-500792 | GPCR ligand binding | 0.999114 | 0.000 |
R-HSA-392499 | Metabolism of proteins | 0.999128 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999583 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999994 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.880 | 0.196 | 2 | 0.880 |
CLK3 |
0.874 | 0.253 | 1 | 0.823 |
PIM3 |
0.872 | 0.207 | -3 | 0.843 |
NDR2 |
0.871 | 0.173 | -3 | 0.846 |
RSK2 |
0.868 | 0.192 | -3 | 0.776 |
CDC7 |
0.864 | 0.059 | 1 | 0.798 |
MTOR |
0.863 | 0.051 | 1 | 0.791 |
PRKD1 |
0.862 | 0.185 | -3 | 0.839 |
SKMLCK |
0.861 | 0.203 | -2 | 0.884 |
PRKD2 |
0.861 | 0.182 | -3 | 0.785 |
P90RSK |
0.861 | 0.142 | -3 | 0.777 |
PIM1 |
0.861 | 0.191 | -3 | 0.792 |
NDR1 |
0.860 | 0.109 | -3 | 0.836 |
AURC |
0.860 | 0.231 | -2 | 0.720 |
MOS |
0.859 | 0.083 | 1 | 0.822 |
PRPK |
0.858 | -0.034 | -1 | 0.839 |
SRPK1 |
0.858 | 0.140 | -3 | 0.757 |
CAMK1B |
0.858 | 0.077 | -3 | 0.867 |
HIPK4 |
0.858 | 0.185 | 1 | 0.766 |
NLK |
0.858 | 0.077 | 1 | 0.819 |
RSK3 |
0.857 | 0.129 | -3 | 0.769 |
ERK5 |
0.857 | 0.129 | 1 | 0.828 |
RAF1 |
0.857 | -0.020 | 1 | 0.826 |
CDKL1 |
0.857 | 0.097 | -3 | 0.805 |
MST4 |
0.857 | 0.111 | 2 | 0.862 |
WNK1 |
0.857 | 0.108 | -2 | 0.905 |
ATR |
0.856 | 0.073 | 1 | 0.829 |
IKKB |
0.856 | -0.044 | -2 | 0.745 |
PKACG |
0.855 | 0.134 | -2 | 0.788 |
CDKL5 |
0.855 | 0.123 | -3 | 0.800 |
MAPKAPK2 |
0.854 | 0.132 | -3 | 0.735 |
GRK1 |
0.853 | 0.123 | -2 | 0.779 |
LATS2 |
0.853 | 0.088 | -5 | 0.782 |
TBK1 |
0.853 | -0.044 | 1 | 0.734 |
CAMK2G |
0.853 | -0.010 | 2 | 0.821 |
GCN2 |
0.853 | -0.113 | 2 | 0.815 |
PDHK4 |
0.852 | -0.172 | 1 | 0.838 |
RSK4 |
0.852 | 0.165 | -3 | 0.745 |
CAMK2D |
0.852 | 0.083 | -3 | 0.851 |
PKACB |
0.851 | 0.192 | -2 | 0.729 |
MAPKAPK3 |
0.851 | 0.085 | -3 | 0.783 |
PKN3 |
0.851 | 0.030 | -3 | 0.836 |
KIS |
0.850 | 0.111 | 1 | 0.682 |
ICK |
0.850 | 0.121 | -3 | 0.843 |
NIK |
0.850 | 0.067 | -3 | 0.885 |
DSTYK |
0.850 | -0.055 | 2 | 0.881 |
CAMLCK |
0.850 | 0.105 | -2 | 0.880 |
GRK5 |
0.850 | -0.008 | -3 | 0.873 |
CLK2 |
0.850 | 0.227 | -3 | 0.757 |
PKN2 |
0.849 | 0.049 | -3 | 0.847 |
P70S6KB |
0.849 | 0.095 | -3 | 0.799 |
CHAK2 |
0.849 | 0.029 | -1 | 0.863 |
IKKE |
0.849 | -0.076 | 1 | 0.728 |
CAMK2A |
0.849 | 0.134 | 2 | 0.816 |
BMPR2 |
0.849 | -0.115 | -2 | 0.864 |
NUAK2 |
0.848 | 0.034 | -3 | 0.852 |
RIPK3 |
0.848 | -0.032 | 3 | 0.635 |
ULK2 |
0.848 | -0.132 | 2 | 0.782 |
PKCD |
0.848 | 0.089 | 2 | 0.777 |
PDHK1 |
0.848 | -0.124 | 1 | 0.823 |
DAPK2 |
0.848 | 0.101 | -3 | 0.872 |
PAK1 |
0.847 | 0.125 | -2 | 0.835 |
MARK4 |
0.847 | 0.030 | 4 | 0.843 |
PRKX |
0.847 | 0.187 | -3 | 0.689 |
CAMK2B |
0.847 | 0.113 | 2 | 0.800 |
IKKA |
0.846 | 0.014 | -2 | 0.721 |
AMPKA1 |
0.846 | 0.045 | -3 | 0.866 |
HUNK |
0.846 | -0.059 | 2 | 0.827 |
GRK6 |
0.846 | 0.057 | 1 | 0.822 |
MSK1 |
0.846 | 0.143 | -3 | 0.751 |
SRPK2 |
0.845 | 0.091 | -3 | 0.677 |
CLK4 |
0.845 | 0.156 | -3 | 0.772 |
DYRK2 |
0.844 | 0.121 | 1 | 0.683 |
MNK2 |
0.844 | 0.124 | -2 | 0.836 |
MSK2 |
0.843 | 0.069 | -3 | 0.746 |
NEK6 |
0.843 | -0.055 | -2 | 0.826 |
TSSK1 |
0.843 | 0.090 | -3 | 0.888 |
MASTL |
0.843 | -0.106 | -2 | 0.831 |
TGFBR2 |
0.843 | -0.059 | -2 | 0.752 |
MLK1 |
0.843 | -0.093 | 2 | 0.809 |
AURB |
0.842 | 0.158 | -2 | 0.722 |
PAK3 |
0.842 | 0.076 | -2 | 0.832 |
PKCB |
0.842 | 0.073 | 2 | 0.725 |
PKCA |
0.842 | 0.093 | 2 | 0.716 |
CDK18 |
0.841 | 0.098 | 1 | 0.613 |
NIM1 |
0.841 | 0.002 | 3 | 0.676 |
CDK8 |
0.841 | 0.039 | 1 | 0.661 |
PKCG |
0.841 | 0.058 | 2 | 0.730 |
PAK6 |
0.841 | 0.139 | -2 | 0.777 |
LATS1 |
0.841 | 0.116 | -3 | 0.844 |
CLK1 |
0.840 | 0.139 | -3 | 0.752 |
DLK |
0.840 | -0.061 | 1 | 0.831 |
AMPKA2 |
0.840 | 0.036 | -3 | 0.831 |
BCKDK |
0.840 | -0.133 | -1 | 0.775 |
MLK2 |
0.840 | -0.021 | 2 | 0.816 |
HIPK2 |
0.840 | 0.151 | 1 | 0.598 |
TSSK2 |
0.840 | 0.020 | -5 | 0.850 |
CDK19 |
0.840 | 0.061 | 1 | 0.627 |
GRK7 |
0.839 | 0.117 | 1 | 0.774 |
PRKD3 |
0.839 | 0.075 | -3 | 0.752 |
MNK1 |
0.839 | 0.109 | -2 | 0.836 |
CDK7 |
0.839 | 0.040 | 1 | 0.665 |
WNK3 |
0.838 | -0.161 | 1 | 0.808 |
PIM2 |
0.838 | 0.142 | -3 | 0.752 |
BMPR1B |
0.838 | 0.107 | 1 | 0.788 |
SRPK3 |
0.838 | 0.063 | -3 | 0.725 |
PKG2 |
0.838 | 0.122 | -2 | 0.729 |
PKCZ |
0.838 | 0.070 | 2 | 0.771 |
NEK7 |
0.838 | -0.192 | -3 | 0.826 |
CDK1 |
0.838 | 0.060 | 1 | 0.633 |
IRE1 |
0.838 | -0.025 | 1 | 0.802 |
RIPK1 |
0.838 | -0.101 | 1 | 0.816 |
HIPK1 |
0.837 | 0.142 | 1 | 0.711 |
CAMK4 |
0.837 | -0.025 | -3 | 0.831 |
AKT2 |
0.837 | 0.112 | -3 | 0.697 |
P38A |
0.837 | 0.103 | 1 | 0.713 |
QSK |
0.836 | 0.042 | 4 | 0.819 |
ULK1 |
0.836 | -0.191 | -3 | 0.810 |
MYLK4 |
0.836 | 0.078 | -2 | 0.813 |
CDK13 |
0.836 | 0.043 | 1 | 0.641 |
SGK3 |
0.836 | 0.109 | -3 | 0.770 |
PKR |
0.836 | 0.092 | 1 | 0.833 |
AURA |
0.836 | 0.127 | -2 | 0.694 |
P38B |
0.836 | 0.106 | 1 | 0.642 |
NEK9 |
0.835 | -0.114 | 2 | 0.836 |
DNAPK |
0.835 | 0.085 | 1 | 0.705 |
MLK3 |
0.835 | -0.029 | 2 | 0.734 |
PAK2 |
0.834 | 0.055 | -2 | 0.826 |
SMG1 |
0.834 | 0.034 | 1 | 0.787 |
JNK2 |
0.834 | 0.083 | 1 | 0.610 |
MELK |
0.834 | 0.008 | -3 | 0.814 |
CDK5 |
0.834 | 0.062 | 1 | 0.688 |
PKACA |
0.834 | 0.147 | -2 | 0.682 |
GRK4 |
0.833 | -0.109 | -2 | 0.792 |
FAM20C |
0.833 | 0.013 | 2 | 0.583 |
QIK |
0.833 | -0.047 | -3 | 0.844 |
ANKRD3 |
0.833 | -0.137 | 1 | 0.849 |
ALK4 |
0.833 | -0.009 | -2 | 0.791 |
TGFBR1 |
0.833 | 0.030 | -2 | 0.756 |
PASK |
0.833 | 0.151 | -3 | 0.860 |
ATM |
0.832 | -0.016 | 1 | 0.762 |
DCAMKL1 |
0.832 | 0.080 | -3 | 0.797 |
PKCH |
0.832 | 0.013 | 2 | 0.710 |
YSK4 |
0.832 | -0.049 | 1 | 0.781 |
CDK12 |
0.831 | 0.048 | 1 | 0.612 |
CDK9 |
0.831 | 0.027 | 1 | 0.652 |
CDK10 |
0.831 | 0.106 | 1 | 0.643 |
JNK3 |
0.830 | 0.049 | 1 | 0.642 |
ERK1 |
0.830 | 0.064 | 1 | 0.631 |
MST3 |
0.830 | 0.102 | 2 | 0.838 |
MPSK1 |
0.830 | 0.218 | 1 | 0.829 |
GSK3A |
0.830 | 0.176 | 4 | 0.529 |
DYRK4 |
0.829 | 0.113 | 1 | 0.611 |
SIK |
0.829 | 0.001 | -3 | 0.768 |
NUAK1 |
0.829 | -0.033 | -3 | 0.790 |
VRK2 |
0.829 | -0.044 | 1 | 0.859 |
CHAK1 |
0.829 | -0.077 | 2 | 0.767 |
CDK17 |
0.829 | 0.046 | 1 | 0.555 |
PHKG1 |
0.829 | -0.039 | -3 | 0.836 |
PLK1 |
0.829 | -0.078 | -2 | 0.768 |
CDK14 |
0.829 | 0.077 | 1 | 0.660 |
MEK1 |
0.829 | -0.111 | 2 | 0.834 |
MARK3 |
0.829 | 0.021 | 4 | 0.784 |
DRAK1 |
0.828 | 0.010 | 1 | 0.786 |
P38G |
0.828 | 0.057 | 1 | 0.548 |
NEK2 |
0.828 | -0.048 | 2 | 0.805 |
TTBK2 |
0.828 | -0.187 | 2 | 0.709 |
CAMK1G |
0.827 | 0.012 | -3 | 0.766 |
IRE2 |
0.827 | -0.062 | 2 | 0.736 |
GSK3B |
0.827 | 0.139 | 4 | 0.522 |
CHK1 |
0.827 | 0.001 | -3 | 0.828 |
BRSK1 |
0.827 | -0.038 | -3 | 0.798 |
PRP4 |
0.827 | 0.116 | -3 | 0.810 |
DYRK1A |
0.827 | 0.075 | 1 | 0.718 |
CDK3 |
0.826 | 0.051 | 1 | 0.573 |
CDK2 |
0.826 | -0.022 | 1 | 0.717 |
MLK4 |
0.825 | -0.085 | 2 | 0.718 |
HIPK3 |
0.825 | 0.087 | 1 | 0.699 |
GAK |
0.825 | 0.268 | 1 | 0.900 |
DYRK1B |
0.825 | 0.085 | 1 | 0.651 |
AKT1 |
0.825 | 0.109 | -3 | 0.715 |
P38D |
0.825 | 0.106 | 1 | 0.562 |
WNK4 |
0.825 | 0.005 | -2 | 0.904 |
ERK2 |
0.825 | 0.013 | 1 | 0.677 |
MARK2 |
0.824 | -0.011 | 4 | 0.749 |
BRSK2 |
0.824 | -0.067 | -3 | 0.824 |
DYRK3 |
0.824 | 0.107 | 1 | 0.706 |
TLK2 |
0.824 | -0.038 | 1 | 0.776 |
ALK2 |
0.824 | -0.009 | -2 | 0.770 |
PLK3 |
0.823 | -0.069 | 2 | 0.778 |
ACVR2A |
0.823 | -0.027 | -2 | 0.736 |
PAK5 |
0.823 | 0.092 | -2 | 0.721 |
ACVR2B |
0.823 | -0.024 | -2 | 0.744 |
P70S6K |
0.822 | 0.043 | -3 | 0.706 |
MAK |
0.822 | 0.185 | -2 | 0.785 |
CDK16 |
0.822 | 0.062 | 1 | 0.574 |
PKCT |
0.822 | 0.027 | 2 | 0.719 |
MAPKAPK5 |
0.822 | -0.071 | -3 | 0.717 |
TAO3 |
0.821 | 0.026 | 1 | 0.801 |
PLK4 |
0.821 | -0.099 | 2 | 0.638 |
GRK2 |
0.821 | -0.040 | -2 | 0.679 |
CK1E |
0.820 | 0.012 | -3 | 0.604 |
ZAK |
0.820 | -0.102 | 1 | 0.787 |
PKCI |
0.820 | 0.039 | 2 | 0.737 |
SMMLCK |
0.819 | 0.030 | -3 | 0.822 |
MARK1 |
0.819 | -0.045 | 4 | 0.799 |
NEK5 |
0.819 | -0.004 | 1 | 0.839 |
PKCE |
0.819 | 0.072 | 2 | 0.713 |
IRAK4 |
0.819 | -0.032 | 1 | 0.812 |
PAK4 |
0.819 | 0.093 | -2 | 0.726 |
CAMK1D |
0.818 | 0.045 | -3 | 0.691 |
MEK5 |
0.818 | -0.187 | 2 | 0.819 |
DCAMKL2 |
0.818 | -0.010 | -3 | 0.816 |
MEKK1 |
0.818 | -0.104 | 1 | 0.805 |
BUB1 |
0.818 | 0.231 | -5 | 0.818 |
LKB1 |
0.818 | 0.094 | -3 | 0.845 |
SNRK |
0.817 | -0.181 | 2 | 0.671 |
MEKK3 |
0.817 | -0.161 | 1 | 0.809 |
GCK |
0.816 | 0.093 | 1 | 0.806 |
AKT3 |
0.816 | 0.106 | -3 | 0.633 |
MEKK2 |
0.816 | -0.092 | 2 | 0.800 |
BRAF |
0.816 | -0.117 | -4 | 0.839 |
SSTK |
0.816 | 0.004 | 4 | 0.809 |
DAPK3 |
0.815 | 0.099 | -3 | 0.807 |
PERK |
0.815 | -0.141 | -2 | 0.807 |
CAMKK1 |
0.815 | -0.028 | -2 | 0.790 |
BMPR1A |
0.814 | 0.020 | 1 | 0.754 |
PHKG2 |
0.814 | -0.044 | -3 | 0.812 |
CAMKK2 |
0.813 | 0.024 | -2 | 0.794 |
CK2A2 |
0.813 | 0.088 | 1 | 0.670 |
HPK1 |
0.812 | 0.073 | 1 | 0.795 |
ROCK2 |
0.812 | 0.144 | -3 | 0.794 |
SGK1 |
0.812 | 0.095 | -3 | 0.612 |
CK1D |
0.811 | 0.018 | -3 | 0.555 |
CK1A2 |
0.811 | 0.023 | -3 | 0.556 |
TNIK |
0.811 | 0.080 | 3 | 0.774 |
PINK1 |
0.811 | -0.166 | 1 | 0.827 |
MOK |
0.811 | 0.128 | 1 | 0.741 |
DAPK1 |
0.811 | 0.087 | -3 | 0.792 |
PBK |
0.811 | 0.221 | 1 | 0.838 |
NEK11 |
0.810 | -0.117 | 1 | 0.792 |
MEKK6 |
0.810 | 0.007 | 1 | 0.811 |
MRCKB |
0.810 | 0.101 | -3 | 0.744 |
HRI |
0.810 | -0.223 | -2 | 0.814 |
ERK7 |
0.810 | 0.030 | 2 | 0.546 |
MRCKA |
0.809 | 0.095 | -3 | 0.753 |
TAO2 |
0.809 | -0.057 | 2 | 0.835 |
JNK1 |
0.809 | 0.027 | 1 | 0.598 |
KHS1 |
0.809 | 0.103 | 1 | 0.781 |
HGK |
0.809 | 0.020 | 3 | 0.774 |
CK1G1 |
0.808 | -0.027 | -3 | 0.574 |
MINK |
0.808 | 0.018 | 1 | 0.800 |
CDK6 |
0.808 | 0.034 | 1 | 0.636 |
KHS2 |
0.807 | 0.101 | 1 | 0.796 |
TLK1 |
0.807 | -0.176 | -2 | 0.765 |
GRK3 |
0.807 | -0.035 | -2 | 0.630 |
MAP3K15 |
0.807 | -0.026 | 1 | 0.773 |
NEK4 |
0.806 | -0.056 | 1 | 0.800 |
CK2A1 |
0.806 | 0.091 | 1 | 0.654 |
CDK4 |
0.806 | 0.028 | 1 | 0.601 |
LRRK2 |
0.806 | -0.036 | 2 | 0.841 |
PDK1 |
0.806 | -0.068 | 1 | 0.778 |
DMPK1 |
0.806 | 0.155 | -3 | 0.768 |
NEK8 |
0.805 | -0.155 | 2 | 0.810 |
LOK |
0.805 | 0.015 | -2 | 0.791 |
CHK2 |
0.805 | 0.021 | -3 | 0.644 |
SBK |
0.804 | 0.063 | -3 | 0.576 |
PKN1 |
0.804 | -0.017 | -3 | 0.731 |
EEF2K |
0.803 | -0.048 | 3 | 0.739 |
CAMK1A |
0.803 | 0.033 | -3 | 0.659 |
NEK1 |
0.803 | 0.003 | 1 | 0.812 |
MST2 |
0.803 | -0.081 | 1 | 0.806 |
STK33 |
0.802 | -0.103 | 2 | 0.627 |
IRAK1 |
0.801 | -0.250 | -1 | 0.729 |
TAK1 |
0.801 | -0.073 | 1 | 0.802 |
PLK2 |
0.801 | -0.012 | -3 | 0.781 |
SLK |
0.800 | -0.035 | -2 | 0.726 |
MST1 |
0.800 | -0.058 | 1 | 0.795 |
VRK1 |
0.799 | -0.080 | 2 | 0.839 |
TTBK1 |
0.799 | -0.214 | 2 | 0.632 |
CRIK |
0.798 | 0.112 | -3 | 0.711 |
YSK1 |
0.798 | -0.022 | 2 | 0.806 |
ROCK1 |
0.796 | 0.101 | -3 | 0.758 |
PDHK3_TYR |
0.795 | 0.286 | 4 | 0.886 |
PKG1 |
0.794 | 0.039 | -2 | 0.656 |
BIKE |
0.793 | 0.201 | 1 | 0.820 |
HASPIN |
0.793 | 0.078 | -1 | 0.774 |
OSR1 |
0.790 | -0.027 | 2 | 0.802 |
MYO3B |
0.789 | 0.039 | 2 | 0.812 |
MEK2 |
0.789 | -0.216 | 2 | 0.803 |
PDHK4_TYR |
0.788 | 0.156 | 2 | 0.883 |
YANK3 |
0.788 | -0.030 | 2 | 0.424 |
TESK1_TYR |
0.786 | 0.053 | 3 | 0.812 |
RIPK2 |
0.786 | -0.289 | 1 | 0.735 |
NEK3 |
0.785 | -0.103 | 1 | 0.764 |
MAP2K4_TYR |
0.785 | 0.092 | -1 | 0.855 |
PKMYT1_TYR |
0.784 | 0.091 | 3 | 0.777 |
MAP2K6_TYR |
0.784 | 0.077 | -1 | 0.860 |
LIMK2_TYR |
0.784 | 0.129 | -3 | 0.896 |
ASK1 |
0.783 | -0.085 | 1 | 0.760 |
BMPR2_TYR |
0.783 | 0.063 | -1 | 0.852 |
AAK1 |
0.782 | 0.249 | 1 | 0.739 |
TTK |
0.782 | -0.079 | -2 | 0.779 |
MAP2K7_TYR |
0.781 | -0.071 | 2 | 0.858 |
TAO1 |
0.779 | -0.078 | 1 | 0.728 |
MYO3A |
0.778 | -0.077 | 1 | 0.781 |
PINK1_TYR |
0.776 | -0.127 | 1 | 0.834 |
PDHK1_TYR |
0.776 | -0.057 | -1 | 0.852 |
CK1A |
0.775 | -0.011 | -3 | 0.461 |
LIMK1_TYR |
0.771 | -0.109 | 2 | 0.842 |
EPHA6 |
0.770 | -0.009 | -1 | 0.802 |
RET |
0.769 | -0.109 | 1 | 0.804 |
ALPHAK3 |
0.767 | -0.138 | -1 | 0.752 |
EPHB4 |
0.767 | -0.015 | -1 | 0.767 |
ABL2 |
0.767 | 0.054 | -1 | 0.749 |
FGR |
0.767 | -0.003 | 1 | 0.877 |
STLK3 |
0.765 | -0.188 | 1 | 0.751 |
DDR1 |
0.765 | -0.146 | 4 | 0.817 |
ABL1 |
0.764 | 0.044 | -1 | 0.736 |
MST1R |
0.764 | -0.161 | 3 | 0.706 |
TNK2 |
0.763 | -0.012 | 3 | 0.649 |
TYK2 |
0.763 | -0.213 | 1 | 0.798 |
TYRO3 |
0.763 | -0.149 | 3 | 0.686 |
TXK |
0.762 | 0.032 | 1 | 0.821 |
CSF1R |
0.762 | -0.125 | 3 | 0.683 |
JAK2 |
0.762 | -0.166 | 1 | 0.793 |
NEK10_TYR |
0.761 | -0.043 | 1 | 0.700 |
ROS1 |
0.761 | -0.167 | 3 | 0.641 |
YES1 |
0.761 | -0.053 | -1 | 0.773 |
TNK1 |
0.761 | -0.013 | 3 | 0.676 |
JAK3 |
0.759 | -0.158 | 1 | 0.787 |
TNNI3K_TYR |
0.759 | -0.014 | 1 | 0.799 |
ITK |
0.759 | -0.041 | -1 | 0.730 |
EPHA4 |
0.758 | -0.065 | 2 | 0.780 |
FER |
0.757 | -0.165 | 1 | 0.843 |
LCK |
0.755 | -0.006 | -1 | 0.757 |
KDR |
0.754 | -0.148 | 3 | 0.645 |
HCK |
0.754 | -0.101 | -1 | 0.756 |
INSRR |
0.753 | -0.197 | 3 | 0.632 |
FGFR2 |
0.753 | -0.212 | 3 | 0.703 |
KIT |
0.753 | -0.170 | 3 | 0.697 |
SRMS |
0.752 | -0.129 | 1 | 0.829 |
YANK2 |
0.752 | -0.071 | 2 | 0.433 |
BLK |
0.751 | -0.008 | -1 | 0.758 |
EPHB3 |
0.751 | -0.110 | -1 | 0.740 |
PDGFRB |
0.751 | -0.230 | 3 | 0.692 |
WEE1_TYR |
0.751 | -0.105 | -1 | 0.726 |
MERTK |
0.751 | -0.094 | 3 | 0.678 |
EPHB1 |
0.751 | -0.156 | 1 | 0.824 |
MET |
0.750 | -0.127 | 3 | 0.687 |
FYN |
0.750 | 0.002 | -1 | 0.741 |
AXL |
0.750 | -0.160 | 3 | 0.670 |
EPHB2 |
0.750 | -0.104 | -1 | 0.730 |
JAK1 |
0.749 | -0.135 | 1 | 0.744 |
BMX |
0.749 | -0.073 | -1 | 0.674 |
FLT3 |
0.748 | -0.228 | 3 | 0.689 |
DDR2 |
0.748 | -0.047 | 3 | 0.619 |
FLT1 |
0.746 | -0.154 | -1 | 0.777 |
CK1G3 |
0.746 | -0.054 | -3 | 0.412 |
EPHA3 |
0.745 | -0.141 | 2 | 0.753 |
TEK |
0.745 | -0.260 | 3 | 0.624 |
FGFR1 |
0.745 | -0.264 | 3 | 0.654 |
TEC |
0.744 | -0.153 | -1 | 0.664 |
BTK |
0.743 | -0.236 | -1 | 0.698 |
EPHA7 |
0.743 | -0.133 | 2 | 0.776 |
PTK2B |
0.742 | -0.053 | -1 | 0.692 |
PTK6 |
0.741 | -0.233 | -1 | 0.662 |
LTK |
0.741 | -0.195 | 3 | 0.629 |
PDGFRA |
0.741 | -0.315 | 3 | 0.683 |
FGFR3 |
0.741 | -0.229 | 3 | 0.670 |
EPHA1 |
0.741 | -0.153 | 3 | 0.658 |
ERBB2 |
0.740 | -0.229 | 1 | 0.765 |
NTRK1 |
0.740 | -0.271 | -1 | 0.766 |
PTK2 |
0.739 | 0.008 | -1 | 0.753 |
ALK |
0.739 | -0.243 | 3 | 0.596 |
SRC |
0.739 | -0.084 | -1 | 0.727 |
LYN |
0.738 | -0.134 | 3 | 0.621 |
FRK |
0.737 | -0.182 | -1 | 0.756 |
INSR |
0.736 | -0.241 | 3 | 0.609 |
FLT4 |
0.736 | -0.275 | 3 | 0.652 |
NTRK3 |
0.736 | -0.192 | -1 | 0.723 |
NTRK2 |
0.736 | -0.290 | 3 | 0.649 |
EPHA5 |
0.735 | -0.130 | 2 | 0.761 |
MATK |
0.735 | -0.162 | -1 | 0.682 |
CSK |
0.734 | -0.175 | 2 | 0.779 |
EPHA8 |
0.733 | -0.140 | -1 | 0.730 |
SYK |
0.733 | -0.038 | -1 | 0.732 |
EGFR |
0.732 | -0.146 | 1 | 0.682 |
CK1G2 |
0.729 | -0.062 | -3 | 0.500 |
FGFR4 |
0.727 | -0.175 | -1 | 0.702 |
EPHA2 |
0.725 | -0.135 | -1 | 0.709 |
MUSK |
0.723 | -0.189 | 1 | 0.687 |
IGF1R |
0.722 | -0.222 | 3 | 0.563 |
ERBB4 |
0.720 | -0.127 | 1 | 0.695 |
ZAP70 |
0.717 | -0.033 | -1 | 0.688 |
FES |
0.707 | -0.208 | -1 | 0.641 |