Motif 522 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14640 | DVL1 | S115 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O60706 | ABCC9 | S658 | ochoa | ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) | Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (PubMed:9831708). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity). {ECO:0000250|UniProtKB:P70170, ECO:0000269|PubMed:9831708}. |
| O60861 | GAS7 | S152 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
| O60885 | BRD4 | S494 | psp | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75128 | COBL | S317 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O94804 | STK10 | S450 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94804 | STK10 | S489 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94915 | FRYL | S1935 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95071 | UBR5 | S694 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95235 | KIF20A | S33 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95696 | BRD1 | S502 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| P04792 | HSPB1 | S82 | ochoa|psp | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P06400 | RB1 | S624 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06400 | RB1 | S838 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P09769 | FGR | S54 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P11274 | BCR | S235 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P16150 | SPN | S351 | ochoa|psp | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P21333 | FLNA | S2339 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21462 | FPR1 | S328 | psp | fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:15153520, PubMed:15210802, PubMed:1712023, PubMed:2161213). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:10514456, PubMed:1712023). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000269|PubMed:25109685, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}. |
| P29350 | PTPN6 | S553 | psp | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P33981 | TTK | Y833 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P39880 | CUX1 | S1333 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P43403 | ZAP70 | S313 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P50750 | CDK9 | S353 | ochoa|psp | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:16427012, PubMed:20930849, PubMed:28426094, PubMed:30134174). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE (PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:16427012, PubMed:20081228, PubMed:20980437, PubMed:21127351, PubMed:9857195). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:10912001, PubMed:11112772, PubMed:9857195). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity (PubMed:29335245). {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11145967, ECO:0000269|PubMed:11575923, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:11884399, ECO:0000269|PubMed:12037670, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15564463, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:17956865, ECO:0000269|PubMed:18362169, ECO:0000269|PubMed:19575011, ECO:0000269|PubMed:19844166, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:20930849, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:9857195}. |
| P53350 | PLK1 | S326 | psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P54136 | RARS1 | S378 | ochoa | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}. |
| P60709 | ACTB | S344 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P63261 | ACTG1 | S344 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P82094 | TMF1 | S156 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P82094 | TMF1 | S413 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q02040 | AKAP17A | S511 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q03188 | CENPC | S538 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q07157 | TJP1 | S837 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08050 | FOXM1 | S501 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12968 | NFATC3 | S177 | psp | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13107 | USP4 | S592 | ochoa | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) | Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16339847, PubMed:16472766, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766, PubMed:30514904). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (PubMed:30514904). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:22347420, ECO:0000269|PubMed:25404403, ECO:0000269|PubMed:28604766, ECO:0000269|PubMed:30514904}. |
| Q13330 | MTA1 | S558 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13422 | IKZF1 | S364 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13480 | GAB1 | S256 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13480 | GAB1 | S367 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13501 | SQSTM1 | S403 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13873 | BMPR2 | S940 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14517 | FAT1 | S4272 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14938 | NFIX | S280 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q14980 | NUMA1 | S1788 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S2047 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15398 | DLGAP5 | S630 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15648 | MED1 | S770 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q2KHR3 | QSER1 | S987 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2M2I8 | AAK1 | S690 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2QGD7 | ZXDC | S651 | ochoa | Zinc finger protein ZXDC (ZXD-like zinc finger protein) | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}. |
| Q562F6 | SGO2 | S278 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q58EX2 | SDK2 | S2101 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5HYJ3 | FAM76B | S227 | ochoa | Protein FAM76B | Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}. |
| Q5M775 | SPECC1 | S360 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SXM2 | SNAPC4 | S1394 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5T4S7 | UBR4 | S2718 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T5C0 | STXBP5 | S688 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5TCZ1 | SH3PXD2A | S638 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VT52 | RPRD2 | S942 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUB5 | FAM171A1 | S640 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VZ89 | DENND4C | S999 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HK5 | TSHZ3 | S596 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q68DQ2 | CRYBG3 | S2116 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6KC79 | NIPBL | S148 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PIJ6 | FBXO38 | S736 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Q6T4R5 | NHS | S1188 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UXY1 | BAIAP2L2 | S477 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6WCQ1 | MPRIP | S377 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZN16 | MAP3K15 | S946 | ochoa | Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) | Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}. |
| Q765P7 | MTSS2 | S324 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q86SQ0 | PHLDB2 | S565 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86US8 | SMG6 | S870 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UU1 | PHLDB1 | S191 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86W92 | PPFIBP1 | S636 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q86WB0 | ZC3HC1 | S407 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86X29 | LSR | S385 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YS7 | C2CD5 | S280 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q86YT6 | MIB1 | S405 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IV63 | VRK3 | S71 | ochoa | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
| Q8IWC1 | MAP7D3 | S453 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IZD2 | KMT2E | S1082 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8N4S9 | MARVELD2 | S140 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8N612 | FHIP1B | S855 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NCG7 | DAGLB | S175 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8TBP0 | TBC1D16 | S122 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TD55 | PLEKHO2 | S244 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TES7 | FBF1 | S142 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TF72 | SHROOM3 | S1486 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUA4 | GTF3C2 | S772 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUB8 | PHF10 | S297 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WXE9 | STON2 | S354 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WXI9 | GATAD2B | S134 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92576 | PHF3 | S702 | ochoa | PHD finger protein 3 | None |
| Q92997 | DVL3 | S112 | ochoa | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96GX5 | MASTL | S593 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96GX5 | MASTL | S631 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96JY6 | PDLIM2 | S209 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96PD2 | DCBLD2 | S720 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96Q89 | KIF20B | S1588 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96SU4 | OSBPL9 | S344 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q96T88 | UHRF1 | S91 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99460 | PSMD1 | S290 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99569 | PKP4 | S139 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99569 | PKP4 | S259 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BQE9 | BCL7B | S134 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BRD0 | BUD13 | S311 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BY89 | KIAA1671 | S1669 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0H5 | ARHGAP39 | S135 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9HAU0 | PLEKHA5 | S861 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NQC3 | RTN4 | S738 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NSI6 | BRWD1 | S2162 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NZ09 | UBAP1 | S249 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9P2F8 | SIPA1L2 | S160 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBY5 | LPAR3 | S331 | ochoa | Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. |
| Q9UHB7 | AFF4 | S706 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHW9 | SLC12A6 | S96 | ochoa|psp | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UKF7 | PITPNC1 | S273 | ochoa | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) | [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}. |
| Q9ULH1 | ASAP1 | S738 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULM3 | YEATS2 | S144 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UQ26 | RIMS2 | S1144 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9Y365 | STARD10 | S246 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y6Q9 | NCOA3 | S563 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6Q9 | NCOA3 | S916 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6Y0 | IVNS1ABP | S334 | ochoa | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201). {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}. |
| P13667 | PDIA4 | S379 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P63151 | PPP2R2A | S75 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q00005 | PPP2R2B | S71 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}. |
| Q66LE6 | PPP2R2D | S81 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| P27797 | CALR | S189 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P29323 | EPHB2 | S914 | Sugiyama | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| Q9BT78 | COPS4 | S298 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Q9H4A4 | RNPEP | S27 | Sugiyama | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 7.375727e-07 | 6.132 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.205702e-06 | 5.919 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.101190e-06 | 5.958 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.205702e-06 | 5.919 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 3.288328e-04 | 3.483 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 6.515526e-04 | 3.186 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 5.575165e-04 | 3.254 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 6.515526e-04 | 3.186 |
| R-HSA-68886 | M Phase | 8.495804e-04 | 3.071 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 9.117041e-04 | 3.040 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.126878e-03 | 2.948 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.428967e-03 | 2.845 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.623251e-03 | 2.581 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.623251e-03 | 2.581 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 2.294472e-03 | 2.639 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.928869e-03 | 2.715 |
| R-HSA-199991 | Membrane Trafficking | 2.182826e-03 | 2.661 |
| R-HSA-4839726 | Chromatin organization | 2.582622e-03 | 2.588 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.353976e-03 | 2.628 |
| R-HSA-162582 | Signal Transduction | 2.025226e-03 | 2.694 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.090580e-03 | 2.510 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.249914e-03 | 2.488 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.980947e-03 | 2.400 |
| R-HSA-196025 | Formation of annular gap junctions | 4.264734e-03 | 2.370 |
| R-HSA-190873 | Gap junction degradation | 5.046695e-03 | 2.297 |
| R-HSA-201688 | WNT mediated activation of DVL | 5.046695e-03 | 2.297 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 5.046695e-03 | 2.297 |
| R-HSA-2025928 | Calcineurin activates NFAT | 5.046695e-03 | 2.297 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.966845e-03 | 2.304 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.890836e-03 | 2.230 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 6.492095e-03 | 2.188 |
| R-HSA-74158 | RNA Polymerase III Transcription | 6.492095e-03 | 2.188 |
| R-HSA-68875 | Mitotic Prophase | 6.590644e-03 | 2.181 |
| R-HSA-4641258 | Degradation of DVL | 6.912156e-03 | 2.160 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 7.752668e-03 | 2.111 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 8.656616e-03 | 2.063 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 9.252109e-03 | 2.034 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 9.845951e-03 | 2.007 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 9.845951e-03 | 2.007 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.085211e-02 | 1.964 |
| R-HSA-1640170 | Cell Cycle | 1.137648e-02 | 1.944 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.097622e-02 | 1.960 |
| R-HSA-9664420 | Killing mechanisms | 1.339890e-02 | 1.873 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.339890e-02 | 1.873 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.260244e-02 | 1.900 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.373082e-02 | 1.862 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.385388e-02 | 1.858 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.656194e-02 | 1.781 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.742328e-02 | 1.759 |
| R-HSA-373756 | SDK interactions | 1.723883e-02 | 1.763 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.742328e-02 | 1.759 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.751026e-02 | 1.757 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.954588e-02 | 1.709 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 2.574726e-02 | 1.589 |
| R-HSA-5678420 | Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome | 2.574726e-02 | 1.589 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 2.574726e-02 | 1.589 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 3.418256e-02 | 1.466 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 3.418256e-02 | 1.466 |
| R-HSA-8865999 | MET activates PTPN11 | 4.254534e-02 | 1.371 |
| R-HSA-8941237 | Invadopodia formation | 4.254534e-02 | 1.371 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 5.083622e-02 | 1.294 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 8.329295e-02 | 1.079 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 9.123344e-02 | 1.040 |
| R-HSA-8875656 | MET receptor recycling | 9.123344e-02 | 1.040 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.069101e-01 | 0.971 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.069101e-01 | 0.971 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.299231e-01 | 0.886 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.374625e-01 | 0.862 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.374625e-01 | 0.862 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.596936e-01 | 0.797 |
| R-HSA-3928664 | Ephrin signaling | 1.813558e-01 | 0.741 |
| R-HSA-180292 | GAB1 signalosome | 1.813558e-01 | 0.741 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 1.884525e-01 | 0.725 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.634673e-02 | 1.579 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 1.954882e-01 | 0.709 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.093785e-01 | 0.679 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.162340e-01 | 0.665 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.162340e-01 | 0.665 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.230305e-01 | 0.652 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 9.655940e-02 | 1.015 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.297685e-01 | 0.639 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.364485e-01 | 0.626 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.942177e-02 | 1.306 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.942177e-02 | 1.306 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.496364e-01 | 0.603 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.496364e-01 | 0.603 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.561453e-01 | 0.592 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.561453e-01 | 0.592 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.689954e-01 | 0.570 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.066840e-01 | 0.685 |
| R-HSA-6798695 | Neutrophil degranulation | 1.243896e-01 | 0.905 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.968918e-02 | 1.401 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.070392e-02 | 1.295 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.130187e-01 | 0.672 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.954882e-01 | 0.709 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.162340e-01 | 0.665 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.235033e-01 | 0.908 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.235033e-01 | 0.908 |
| R-HSA-191650 | Regulation of gap junction activity | 5.083622e-02 | 1.294 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.446361e-02 | 1.264 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.012542e-02 | 1.221 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.235033e-01 | 0.908 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.141149e-01 | 0.943 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.223183e-01 | 0.913 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.671108e-02 | 1.246 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.841422e-02 | 1.165 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.753376e-01 | 0.560 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 9.926016e-02 | 1.003 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.816251e-01 | 0.550 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.299231e-01 | 0.886 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.391275e-02 | 1.470 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.841422e-02 | 1.165 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.083095e-02 | 1.092 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.083095e-02 | 1.092 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.083095e-02 | 1.092 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.334742e-02 | 1.135 |
| R-HSA-68877 | Mitotic Prometaphase | 1.144650e-01 | 0.941 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.815582e-02 | 1.317 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.385204e-01 | 0.622 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.580828e-02 | 1.339 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.083622e-02 | 1.294 |
| R-HSA-1296025 | ATP sensitive Potassium channels | 5.083622e-02 | 1.294 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 5.905582e-02 | 1.229 |
| R-HSA-176417 | Phosphorylation of Emi1 | 6.720474e-02 | 1.173 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.329295e-02 | 1.079 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 9.123344e-02 | 1.040 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 9.910564e-02 | 1.004 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.223183e-01 | 0.913 |
| R-HSA-202670 | ERKs are inactivated | 1.223183e-01 | 0.913 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.391275e-02 | 1.470 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.374625e-01 | 0.862 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.374625e-01 | 0.862 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.374625e-01 | 0.862 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.596936e-01 | 0.797 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.813558e-01 | 0.741 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 6.364261e-02 | 1.196 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.884525e-01 | 0.725 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 8.083095e-02 | 1.092 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.625982e-01 | 0.581 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.753376e-01 | 0.560 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.753376e-01 | 0.560 |
| R-HSA-201451 | Signaling by BMP | 2.496364e-01 | 0.603 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.405193e-02 | 1.193 |
| R-HSA-69275 | G2/M Transition | 3.413632e-02 | 1.467 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.523472e-01 | 0.817 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.535578e-02 | 1.452 |
| R-HSA-9843745 | Adipogenesis | 4.016849e-02 | 1.396 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.299231e-01 | 0.886 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.083095e-02 | 1.092 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.741974e-01 | 0.759 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.217522e-02 | 1.492 |
| R-HSA-5334118 | DNA methylation | 2.625982e-01 | 0.581 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.600475e-01 | 0.796 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.449370e-01 | 0.839 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.954882e-01 | 0.709 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.047245e-01 | 0.980 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.496364e-01 | 0.603 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 8.941308e-02 | 1.049 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 9.910564e-02 | 1.004 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.162340e-01 | 0.665 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.529867e-02 | 1.123 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.098489e-01 | 0.678 |
| R-HSA-5617833 | Cilium Assembly | 1.102026e-01 | 0.958 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 6.364261e-02 | 1.196 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 6.364261e-02 | 1.196 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.509721e-01 | 0.821 |
| R-HSA-8964046 | VLDL clearance | 8.329295e-02 | 1.079 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 9.123344e-02 | 1.040 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.069101e-01 | 0.971 |
| R-HSA-426048 | Arachidonate production from DAG | 1.069101e-01 | 0.971 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.449370e-01 | 0.839 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.523472e-01 | 0.817 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.024634e-01 | 0.694 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.625982e-01 | 0.581 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.816251e-01 | 0.550 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.960600e-02 | 1.099 |
| R-HSA-9664873 | Pexophagy | 1.069101e-01 | 0.971 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.625982e-01 | 0.581 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.689954e-01 | 0.570 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.217522e-02 | 1.492 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.217522e-02 | 1.492 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.244519e-01 | 0.905 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.573556e-01 | 0.803 |
| R-HSA-9664407 | Parasite infection | 1.573556e-01 | 0.803 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.573556e-01 | 0.803 |
| R-HSA-69236 | G1 Phase | 7.578394e-02 | 1.120 |
| R-HSA-69231 | Cyclin D associated events in G1 | 7.578394e-02 | 1.120 |
| R-HSA-4086400 | PCP/CE pathway | 3.975445e-02 | 1.401 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.449370e-01 | 0.839 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.580828e-02 | 1.339 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.093785e-01 | 0.679 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.532148e-02 | 1.452 |
| R-HSA-5689603 | UCH proteinases | 1.661530e-01 | 0.779 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.572642e-01 | 0.590 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.116071e-02 | 1.506 |
| R-HSA-9927353 | Co-inhibition by BTLA | 5.905582e-02 | 1.229 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 7.528358e-02 | 1.123 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 8.329295e-02 | 1.079 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.299231e-01 | 0.886 |
| R-HSA-429947 | Deadenylation of mRNA | 2.297685e-01 | 0.639 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.755339e-01 | 0.756 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.481294e-01 | 0.605 |
| R-HSA-437239 | Recycling pathway of L1 | 8.339271e-02 | 1.079 |
| R-HSA-983189 | Kinesins | 1.187261e-01 | 0.925 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.561453e-01 | 0.592 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.449370e-01 | 0.839 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 1.523472e-01 | 0.817 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.792044e-02 | 1.319 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.813558e-01 | 0.741 |
| R-HSA-190828 | Gap junction trafficking | 7.578394e-02 | 1.120 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.425564e-02 | 1.465 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.162340e-01 | 0.665 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.074870e-01 | 0.969 |
| R-HSA-3214847 | HATs acetylate histones | 7.181878e-02 | 1.144 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.802175e-01 | 0.553 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.491427e-01 | 0.826 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.026304e-02 | 1.519 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.561453e-01 | 0.592 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.169187e-02 | 1.380 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.689879e-02 | 1.245 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.385204e-01 | 0.622 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.625982e-01 | 0.581 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 7.829448e-02 | 1.106 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.299231e-01 | 0.886 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.299231e-01 | 0.886 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.596936e-01 | 0.797 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.741974e-01 | 0.759 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.741974e-01 | 0.759 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 7.084315e-02 | 1.150 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.230305e-01 | 0.652 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.364514e-01 | 0.626 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.625982e-01 | 0.581 |
| R-HSA-68882 | Mitotic Anaphase | 5.608146e-02 | 1.251 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.843703e-02 | 1.165 |
| R-HSA-9659379 | Sensory processing of sound | 1.753857e-01 | 0.756 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.479708e-01 | 0.830 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.231054e-01 | 0.910 |
| R-HSA-9658195 | Leishmania infection | 1.231054e-01 | 0.910 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.246886e-01 | 0.904 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 7.528358e-02 | 1.123 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.069101e-01 | 0.971 |
| R-HSA-210990 | PECAM1 interactions | 1.146475e-01 | 0.941 |
| R-HSA-198753 | ERK/MAPK targets | 2.024634e-01 | 0.694 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.430710e-01 | 0.614 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.496364e-01 | 0.603 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.244519e-01 | 0.905 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.420063e-01 | 0.848 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 2.816251e-01 | 0.550 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.479708e-01 | 0.830 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.491427e-01 | 0.826 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.827849e-01 | 0.738 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.187261e-01 | 0.925 |
| R-HSA-8939211 | ESR-mediated signaling | 1.862110e-01 | 0.730 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.024634e-01 | 0.694 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.024634e-01 | 0.694 |
| R-HSA-418346 | Platelet homeostasis | 2.738001e-01 | 0.563 |
| R-HSA-73887 | Death Receptor Signaling | 1.893087e-01 | 0.723 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.329295e-02 | 1.079 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.449370e-01 | 0.839 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.093785e-01 | 0.679 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.815582e-02 | 1.317 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.074870e-01 | 0.969 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.539857e-01 | 0.813 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.160591e-01 | 0.665 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.910564e-02 | 1.004 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.689954e-01 | 0.570 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.982030e-02 | 1.223 |
| R-HSA-373760 | L1CAM interactions | 1.050148e-01 | 0.979 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.513358e-01 | 0.600 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.237489e-01 | 0.650 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.539857e-01 | 0.813 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.123344e-02 | 1.040 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.347715e-02 | 1.629 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.449370e-01 | 0.839 |
| R-HSA-210991 | Basigin interactions | 2.024634e-01 | 0.694 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.661530e-01 | 0.779 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.720538e-01 | 0.764 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.422850e-01 | 0.616 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.689954e-01 | 0.570 |
| R-HSA-74160 | Gene expression (Transcription) | 2.787697e-01 | 0.555 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.387494e-01 | 0.622 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.385204e-01 | 0.622 |
| R-HSA-5619084 | ABC transporter disorders | 1.722987e-01 | 0.764 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.424555e-02 | 1.615 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.025314e-01 | 0.694 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.024634e-01 | 0.694 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.968918e-02 | 1.401 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.162340e-01 | 0.665 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.230305e-01 | 0.652 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.722987e-01 | 0.764 |
| R-HSA-1643685 | Disease | 1.061771e-01 | 0.974 |
| R-HSA-8983711 | OAS antiviral response | 1.299231e-01 | 0.886 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.162340e-01 | 0.665 |
| R-HSA-6783783 | Interleukin-10 signaling | 1.722987e-01 | 0.764 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.747524e-02 | 1.058 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.747524e-02 | 1.058 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.625982e-01 | 0.581 |
| R-HSA-446728 | Cell junction organization | 4.672754e-02 | 1.330 |
| R-HSA-421270 | Cell-cell junction organization | 8.873864e-02 | 1.052 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.630950e-01 | 0.788 |
| R-HSA-1500931 | Cell-Cell communication | 2.819374e-02 | 1.550 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 5.905582e-02 | 1.229 |
| R-HSA-418990 | Adherens junctions interactions | 1.542699e-01 | 0.812 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.705905e-01 | 0.568 |
| R-HSA-6807070 | PTEN Regulation | 1.552892e-01 | 0.809 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.982030e-02 | 1.223 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.496364e-01 | 0.603 |
| R-HSA-8964038 | LDL clearance | 2.162340e-01 | 0.665 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.909467e-01 | 0.719 |
| R-HSA-157118 | Signaling by NOTCH | 7.758458e-02 | 1.110 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.187995e-01 | 0.925 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.374625e-01 | 0.862 |
| R-HSA-168268 | Virus Assembly and Release | 1.596936e-01 | 0.797 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.430710e-01 | 0.614 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.367070e-02 | 1.270 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.741974e-01 | 0.759 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.417215e-01 | 0.617 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.449370e-01 | 0.839 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 1.884525e-01 | 0.725 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.141149e-01 | 0.943 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.545433e-01 | 0.594 |
| R-HSA-2028269 | Signaling by Hippo | 1.741974e-01 | 0.759 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.191684e-02 | 1.208 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.816251e-01 | 0.550 |
| R-HSA-449147 | Signaling by Interleukins | 1.113958e-01 | 0.953 |
| R-HSA-9679506 | SARS-CoV Infections | 2.362655e-01 | 0.627 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.032308e-01 | 0.986 |
| R-HSA-194138 | Signaling by VEGF | 1.235033e-01 | 0.908 |
| R-HSA-202403 | TCR signaling | 2.866310e-01 | 0.543 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.930389e-01 | 0.533 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.930389e-01 | 0.533 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.938575e-01 | 0.532 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.940380e-01 | 0.532 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.940380e-01 | 0.532 |
| R-HSA-9824446 | Viral Infection Pathways | 2.966265e-01 | 0.528 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.971752e-01 | 0.527 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.001644e-01 | 0.523 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.001644e-01 | 0.523 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.001644e-01 | 0.523 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.001644e-01 | 0.523 |
| R-HSA-5205647 | Mitophagy | 3.001644e-01 | 0.523 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.001644e-01 | 0.523 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.001644e-01 | 0.523 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.001644e-01 | 0.523 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.062380e-01 | 0.514 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.062380e-01 | 0.514 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.062380e-01 | 0.514 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.062380e-01 | 0.514 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.062380e-01 | 0.514 |
| R-HSA-169911 | Regulation of Apoptosis | 3.062380e-01 | 0.514 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.062380e-01 | 0.514 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.062380e-01 | 0.514 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.122593e-01 | 0.505 |
| R-HSA-8853659 | RET signaling | 3.122593e-01 | 0.505 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.122593e-01 | 0.505 |
| R-HSA-3371511 | HSF1 activation | 3.122593e-01 | 0.505 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.122593e-01 | 0.505 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.153984e-01 | 0.501 |
| R-HSA-4641257 | Degradation of AXIN | 3.182287e-01 | 0.497 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.182287e-01 | 0.497 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.182287e-01 | 0.497 |
| R-HSA-5663205 | Infectious disease | 3.185576e-01 | 0.497 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.217608e-01 | 0.492 |
| R-HSA-8875878 | MET promotes cell motility | 3.241466e-01 | 0.489 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.241466e-01 | 0.489 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.300135e-01 | 0.481 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.300135e-01 | 0.481 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.300135e-01 | 0.481 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.300135e-01 | 0.481 |
| R-HSA-69541 | Stabilization of p53 | 3.300135e-01 | 0.481 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.300135e-01 | 0.481 |
| R-HSA-201556 | Signaling by ALK | 3.300135e-01 | 0.481 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.344415e-01 | 0.476 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.358299e-01 | 0.474 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.358299e-01 | 0.474 |
| R-HSA-3371568 | Attenuation phase | 3.358299e-01 | 0.474 |
| R-HSA-167169 | HIV Transcription Elongation | 3.358299e-01 | 0.474 |
| R-HSA-202433 | Generation of second messenger molecules | 3.358299e-01 | 0.474 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.358299e-01 | 0.474 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.358299e-01 | 0.474 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.358299e-01 | 0.474 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.376014e-01 | 0.472 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.415961e-01 | 0.466 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.415961e-01 | 0.466 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.415961e-01 | 0.466 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.415961e-01 | 0.466 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.415961e-01 | 0.466 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.415961e-01 | 0.466 |
| R-HSA-69206 | G1/S Transition | 3.439079e-01 | 0.464 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.473126e-01 | 0.459 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.473126e-01 | 0.459 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.473126e-01 | 0.459 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.473126e-01 | 0.459 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.473126e-01 | 0.459 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.473126e-01 | 0.459 |
| R-HSA-8951664 | Neddylation | 3.492789e-01 | 0.457 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.529799e-01 | 0.452 |
| R-HSA-165159 | MTOR signalling | 3.529799e-01 | 0.452 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.529799e-01 | 0.452 |
| R-HSA-73928 | Depyrimidination | 3.529799e-01 | 0.452 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.529799e-01 | 0.452 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.585983e-01 | 0.445 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.585983e-01 | 0.445 |
| R-HSA-8854214 | TBC/RABGAPs | 3.585983e-01 | 0.445 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.585983e-01 | 0.445 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.585983e-01 | 0.445 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.610999e-01 | 0.442 |
| R-HSA-162906 | HIV Infection | 3.634608e-01 | 0.440 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.641682e-01 | 0.439 |
| R-HSA-9907900 | Proteasome assembly | 3.641682e-01 | 0.439 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.689330e-01 | 0.433 |
| R-HSA-9909396 | Circadian clock | 3.689330e-01 | 0.433 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.696901e-01 | 0.432 |
| R-HSA-774815 | Nucleosome assembly | 3.696901e-01 | 0.432 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.696901e-01 | 0.432 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.696901e-01 | 0.432 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.696901e-01 | 0.432 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.696901e-01 | 0.432 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.696901e-01 | 0.432 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.696901e-01 | 0.432 |
| R-HSA-9824272 | Somitogenesis | 3.696901e-01 | 0.432 |
| R-HSA-422475 | Axon guidance | 3.698795e-01 | 0.432 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.751644e-01 | 0.426 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.751644e-01 | 0.426 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.751644e-01 | 0.426 |
| R-HSA-75153 | Apoptotic execution phase | 3.751644e-01 | 0.426 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.805915e-01 | 0.420 |
| R-HSA-1483191 | Synthesis of PC | 3.805915e-01 | 0.420 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.805915e-01 | 0.420 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.860838e-01 | 0.413 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.913056e-01 | 0.407 |
| R-HSA-9766229 | Degradation of CDH1 | 3.913056e-01 | 0.407 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.913056e-01 | 0.407 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.913056e-01 | 0.407 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.935827e-01 | 0.405 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.965935e-01 | 0.402 |
| R-HSA-109704 | PI3K Cascade | 3.965935e-01 | 0.402 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.965935e-01 | 0.402 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.996789e-01 | 0.398 |
| R-HSA-109582 | Hemostasis | 4.010541e-01 | 0.397 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.018358e-01 | 0.396 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.018358e-01 | 0.396 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.018358e-01 | 0.396 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.018358e-01 | 0.396 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.057469e-01 | 0.392 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.070328e-01 | 0.390 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.070328e-01 | 0.390 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.070328e-01 | 0.390 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.070328e-01 | 0.390 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.103110e-01 | 0.387 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.121850e-01 | 0.385 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.121850e-01 | 0.385 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.121850e-01 | 0.385 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.172927e-01 | 0.380 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.172927e-01 | 0.380 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.223564e-01 | 0.374 |
| R-HSA-69242 | S Phase | 4.237728e-01 | 0.373 |
| R-HSA-166520 | Signaling by NTRKs | 4.237728e-01 | 0.373 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.271088e-01 | 0.369 |
| R-HSA-9675108 | Nervous system development | 4.273039e-01 | 0.369 |
| R-HSA-177929 | Signaling by EGFR | 4.273764e-01 | 0.369 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.273764e-01 | 0.369 |
| R-HSA-5578775 | Ion homeostasis | 4.273764e-01 | 0.369 |
| R-HSA-75893 | TNF signaling | 4.273764e-01 | 0.369 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.273764e-01 | 0.369 |
| R-HSA-5688426 | Deubiquitination | 4.287799e-01 | 0.368 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.310749e-01 | 0.365 |
| R-HSA-112399 | IRS-mediated signalling | 4.323531e-01 | 0.364 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.323531e-01 | 0.364 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.323531e-01 | 0.364 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.372868e-01 | 0.359 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.421780e-01 | 0.354 |
| R-HSA-1989781 | PPARA activates gene expression | 4.444446e-01 | 0.352 |
| R-HSA-379724 | tRNA Aminoacylation | 4.470269e-01 | 0.350 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.470269e-01 | 0.350 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.470269e-01 | 0.350 |
| R-HSA-351202 | Metabolism of polyamines | 4.470269e-01 | 0.350 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.470269e-01 | 0.350 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.470269e-01 | 0.350 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.470269e-01 | 0.350 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.470269e-01 | 0.350 |
| R-HSA-9612973 | Autophagy | 4.473646e-01 | 0.349 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.502761e-01 | 0.347 |
| R-HSA-162587 | HIV Life Cycle | 4.502761e-01 | 0.347 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.518340e-01 | 0.345 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.518340e-01 | 0.345 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.518340e-01 | 0.345 |
| R-HSA-450294 | MAP kinase activation | 4.518340e-01 | 0.345 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.565996e-01 | 0.340 |
| R-HSA-9707616 | Heme signaling | 4.565996e-01 | 0.340 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.565996e-01 | 0.340 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.589590e-01 | 0.338 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.613241e-01 | 0.336 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.613241e-01 | 0.336 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.613241e-01 | 0.336 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.613241e-01 | 0.336 |
| R-HSA-109581 | Apoptosis | 4.647038e-01 | 0.333 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 4.660077e-01 | 0.332 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.660077e-01 | 0.332 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.660077e-01 | 0.332 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.706510e-01 | 0.327 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.706510e-01 | 0.327 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.717788e-01 | 0.326 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.748960e-01 | 0.323 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.752541e-01 | 0.323 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.752541e-01 | 0.323 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.831354e-01 | 0.316 |
| R-HSA-167172 | Transcription of the HIV genome | 4.843415e-01 | 0.315 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.928838e-01 | 0.307 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.932727e-01 | 0.307 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.932727e-01 | 0.307 |
| R-HSA-448424 | Interleukin-17 signaling | 4.932727e-01 | 0.307 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.956507e-01 | 0.305 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.976805e-01 | 0.303 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.976805e-01 | 0.303 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.984081e-01 | 0.302 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.020502e-01 | 0.299 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.038941e-01 | 0.298 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.046868e-01 | 0.297 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.063822e-01 | 0.296 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.063822e-01 | 0.296 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.063822e-01 | 0.296 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.106768e-01 | 0.292 |
| R-HSA-380287 | Centrosome maturation | 5.149342e-01 | 0.288 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.149342e-01 | 0.288 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.191549e-01 | 0.285 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.196857e-01 | 0.284 |
| R-HSA-195721 | Signaling by WNT | 5.239267e-01 | 0.281 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.274872e-01 | 0.278 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.274872e-01 | 0.278 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.315994e-01 | 0.274 |
| R-HSA-6806834 | Signaling by MET | 5.356761e-01 | 0.271 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.356761e-01 | 0.271 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.356761e-01 | 0.271 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.397176e-01 | 0.268 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.476960e-01 | 0.261 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.476960e-01 | 0.261 |
| R-HSA-1266738 | Developmental Biology | 5.498032e-01 | 0.260 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.516336e-01 | 0.258 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.516336e-01 | 0.258 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.555372e-01 | 0.255 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.594070e-01 | 0.252 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.594070e-01 | 0.252 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.670465e-01 | 0.246 |
| R-HSA-9663891 | Selective autophagy | 5.708168e-01 | 0.244 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.765454e-01 | 0.239 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.765454e-01 | 0.239 |
| R-HSA-73884 | Base Excision Repair | 5.782598e-01 | 0.238 |
| R-HSA-202424 | Downstream TCR signaling | 5.782598e-01 | 0.238 |
| R-HSA-5357801 | Programmed Cell Death | 5.838580e-01 | 0.234 |
| R-HSA-1280218 | Adaptive Immune System | 5.857862e-01 | 0.232 |
| R-HSA-391251 | Protein folding | 5.891848e-01 | 0.230 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.891848e-01 | 0.230 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.891848e-01 | 0.230 |
| R-HSA-1474244 | Extracellular matrix organization | 5.908243e-01 | 0.229 |
| R-HSA-2029481 | FCGR activation | 5.927636e-01 | 0.227 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.927636e-01 | 0.227 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.927636e-01 | 0.227 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.963115e-01 | 0.225 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.033155e-01 | 0.219 |
| R-HSA-1296071 | Potassium Channels | 6.067721e-01 | 0.217 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.101988e-01 | 0.215 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.127198e-01 | 0.213 |
| R-HSA-190236 | Signaling by FGFR | 6.135958e-01 | 0.212 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.135958e-01 | 0.212 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.135958e-01 | 0.212 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.135958e-01 | 0.212 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.169635e-01 | 0.210 |
| R-HSA-8953854 | Metabolism of RNA | 6.193503e-01 | 0.208 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.203020e-01 | 0.207 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.236116e-01 | 0.205 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.246986e-01 | 0.204 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.268926e-01 | 0.203 |
| R-HSA-1483255 | PI Metabolism | 6.268926e-01 | 0.203 |
| R-HSA-168249 | Innate Immune System | 6.329784e-01 | 0.199 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.333695e-01 | 0.198 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.365661e-01 | 0.196 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.365661e-01 | 0.196 |
| R-HSA-9833110 | RSV-host interactions | 6.365661e-01 | 0.196 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.368441e-01 | 0.196 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.397349e-01 | 0.194 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.428763e-01 | 0.192 |
| R-HSA-73894 | DNA Repair | 6.444451e-01 | 0.191 |
| R-HSA-69239 | Synthesis of DNA | 6.459905e-01 | 0.190 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.490777e-01 | 0.188 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.521383e-01 | 0.186 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.521383e-01 | 0.186 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.551723e-01 | 0.184 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.551723e-01 | 0.184 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.551723e-01 | 0.184 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.561031e-01 | 0.183 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.641175e-01 | 0.178 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.670478e-01 | 0.176 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.728324e-01 | 0.172 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.756871e-01 | 0.170 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.756871e-01 | 0.170 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.813226e-01 | 0.167 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.841038e-01 | 0.165 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.849720e-01 | 0.164 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.868609e-01 | 0.163 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.868609e-01 | 0.163 |
| R-HSA-2262752 | Cellular responses to stress | 6.878749e-01 | 0.162 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.912502e-01 | 0.160 |
| R-HSA-3371556 | Cellular response to heat stress | 6.923037e-01 | 0.160 |
| R-HSA-73886 | Chromosome Maintenance | 6.923037e-01 | 0.160 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.949897e-01 | 0.158 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.949897e-01 | 0.158 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.976524e-01 | 0.156 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.976524e-01 | 0.156 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.002921e-01 | 0.155 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.080746e-01 | 0.150 |
| R-HSA-416476 | G alpha (q) signalling events | 7.090326e-01 | 0.149 |
| R-HSA-114608 | Platelet degranulation | 7.106239e-01 | 0.148 |
| R-HSA-69481 | G2/M Checkpoints | 7.106239e-01 | 0.148 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.131511e-01 | 0.147 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.181400e-01 | 0.144 |
| R-HSA-5576891 | Cardiac conduction | 7.230427e-01 | 0.141 |
| R-HSA-168256 | Immune System | 7.276573e-01 | 0.138 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.278607e-01 | 0.138 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.395447e-01 | 0.131 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.404394e-01 | 0.131 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.418211e-01 | 0.130 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.418211e-01 | 0.130 |
| R-HSA-1632852 | Macroautophagy | 7.485323e-01 | 0.126 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.529098e-01 | 0.123 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.572118e-01 | 0.121 |
| R-HSA-1483257 | Phospholipid metabolism | 7.612968e-01 | 0.118 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.655938e-01 | 0.116 |
| R-HSA-9758941 | Gastrulation | 7.676440e-01 | 0.115 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.696764e-01 | 0.114 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.736884e-01 | 0.111 |
| R-HSA-69306 | DNA Replication | 7.756683e-01 | 0.110 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.776310e-01 | 0.109 |
| R-HSA-9610379 | HCMV Late Events | 7.834174e-01 | 0.106 |
| R-HSA-877300 | Interferon gamma signaling | 7.871917e-01 | 0.104 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.963441e-01 | 0.099 |
| R-HSA-5619102 | SLC transporter disorders | 8.016469e-01 | 0.096 |
| R-HSA-8957322 | Metabolism of steroids | 8.026841e-01 | 0.095 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.134928e-01 | 0.090 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.134928e-01 | 0.090 |
| R-HSA-168255 | Influenza Infection | 8.230856e-01 | 0.085 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.240612e-01 | 0.084 |
| R-HSA-2559583 | Cellular Senescence | 8.246360e-01 | 0.084 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.336595e-01 | 0.079 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.408258e-01 | 0.075 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.449775e-01 | 0.073 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.567986e-01 | 0.067 |
| R-HSA-72172 | mRNA Splicing | 8.593014e-01 | 0.066 |
| R-HSA-6805567 | Keratinization | 8.617608e-01 | 0.065 |
| R-HSA-913531 | Interferon Signaling | 8.687354e-01 | 0.061 |
| R-HSA-397014 | Muscle contraction | 8.688858e-01 | 0.061 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.784014e-01 | 0.056 |
| R-HSA-418594 | G alpha (i) signalling events | 8.889825e-01 | 0.051 |
| R-HSA-72766 | Translation | 9.049770e-01 | 0.043 |
| R-HSA-9609646 | HCMV Infection | 9.062657e-01 | 0.043 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.274843e-01 | 0.033 |
| R-HSA-112316 | Neuronal System | 9.281906e-01 | 0.032 |
| R-HSA-212436 | Generic Transcription Pathway | 9.371310e-01 | 0.028 |
| R-HSA-500792 | GPCR ligand binding | 9.707755e-01 | 0.013 |
| R-HSA-388396 | GPCR downstream signalling | 9.711848e-01 | 0.013 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.748301e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.765761e-01 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 9.771761e-01 | 0.010 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.798676e-01 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 9.838413e-01 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 9.927931e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.975364e-01 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 9.998422e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998542e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.824 | 0.251 | 1 | 0.861 |
GSK3B |
0.824 | 0.563 | 4 | 0.727 |
GSK3A |
0.822 | 0.543 | 4 | 0.728 |
GRK1 |
0.819 | 0.311 | -2 | 0.731 |
CLK3 |
0.817 | 0.216 | 1 | 0.692 |
COT |
0.816 | 0.162 | 2 | 0.890 |
NDR2 |
0.816 | 0.180 | -3 | 0.809 |
GRK6 |
0.815 | 0.386 | 1 | 0.833 |
CAMK2B |
0.815 | 0.292 | 2 | 0.797 |
RSK2 |
0.815 | 0.229 | -3 | 0.760 |
CAMK2A |
0.813 | 0.294 | 2 | 0.798 |
PIM3 |
0.812 | 0.182 | -3 | 0.817 |
MAPKAPK2 |
0.808 | 0.175 | -3 | 0.707 |
MOS |
0.807 | 0.162 | 1 | 0.826 |
CLK2 |
0.807 | 0.254 | -3 | 0.747 |
GRK5 |
0.806 | 0.271 | -3 | 0.850 |
GRK7 |
0.805 | 0.278 | 1 | 0.731 |
RSK4 |
0.805 | 0.216 | -3 | 0.744 |
P90RSK |
0.804 | 0.179 | -3 | 0.762 |
PRKD1 |
0.804 | 0.112 | -3 | 0.777 |
CAMK2G |
0.803 | 0.175 | 2 | 0.808 |
CAMK1B |
0.803 | 0.129 | -3 | 0.825 |
MSK1 |
0.802 | 0.221 | -3 | 0.740 |
BMPR1B |
0.801 | 0.208 | 1 | 0.864 |
PIM1 |
0.800 | 0.166 | -3 | 0.779 |
PRKX |
0.799 | 0.207 | -3 | 0.676 |
CAMK2D |
0.799 | 0.178 | -3 | 0.783 |
SKMLCK |
0.799 | 0.162 | -2 | 0.855 |
IKKB |
0.799 | 0.061 | -2 | 0.687 |
PRKD2 |
0.799 | 0.111 | -3 | 0.726 |
LATS2 |
0.797 | 0.112 | -5 | 0.770 |
LATS1 |
0.797 | 0.247 | -3 | 0.818 |
FAM20C |
0.797 | 0.140 | 2 | 0.638 |
PRPK |
0.797 | 0.000 | -1 | 0.858 |
MTOR |
0.796 | 0.031 | 1 | 0.677 |
RSK3 |
0.796 | 0.111 | -3 | 0.742 |
RAF1 |
0.796 | -0.012 | 1 | 0.788 |
CK2A2 |
0.796 | 0.264 | 1 | 0.780 |
MSK2 |
0.796 | 0.148 | -3 | 0.748 |
GRK4 |
0.796 | 0.162 | -2 | 0.780 |
HIPK4 |
0.795 | 0.070 | 1 | 0.679 |
IKKA |
0.794 | 0.097 | -2 | 0.678 |
PKACG |
0.794 | 0.132 | -2 | 0.758 |
CK2A1 |
0.794 | 0.309 | 1 | 0.772 |
ATR |
0.794 | 0.037 | 1 | 0.747 |
P70S6KB |
0.794 | 0.125 | -3 | 0.769 |
SRPK1 |
0.794 | 0.094 | -3 | 0.767 |
PKN3 |
0.793 | 0.055 | -3 | 0.791 |
NDR1 |
0.793 | 0.064 | -3 | 0.795 |
CDKL1 |
0.793 | 0.069 | -3 | 0.800 |
PKACB |
0.793 | 0.164 | -2 | 0.721 |
AURC |
0.792 | 0.126 | -2 | 0.715 |
PDHK4 |
0.792 | -0.020 | 1 | 0.771 |
NUAK2 |
0.792 | 0.052 | -3 | 0.805 |
MAPKAPK3 |
0.792 | 0.087 | -3 | 0.730 |
DAPK2 |
0.791 | 0.120 | -3 | 0.824 |
TGFBR1 |
0.791 | 0.152 | -2 | 0.778 |
CAMLCK |
0.790 | 0.104 | -2 | 0.849 |
GCN2 |
0.790 | -0.109 | 2 | 0.799 |
DSTYK |
0.789 | -0.013 | 2 | 0.896 |
TBK1 |
0.789 | -0.063 | 1 | 0.671 |
AURA |
0.789 | 0.139 | -2 | 0.701 |
ATM |
0.789 | 0.051 | 1 | 0.714 |
PASK |
0.788 | 0.273 | -3 | 0.838 |
MST4 |
0.788 | 0.029 | 2 | 0.878 |
CLK4 |
0.788 | 0.153 | -3 | 0.763 |
AMPKA1 |
0.788 | 0.034 | -3 | 0.801 |
IKKE |
0.788 | -0.048 | 1 | 0.676 |
MARK4 |
0.788 | -0.002 | 4 | 0.417 |
DLK |
0.788 | 0.119 | 1 | 0.794 |
GRK2 |
0.788 | 0.152 | -2 | 0.689 |
BMPR2 |
0.788 | -0.070 | -2 | 0.842 |
HUNK |
0.788 | -0.001 | 2 | 0.824 |
BMPR1A |
0.787 | 0.185 | 1 | 0.853 |
SRPK2 |
0.787 | 0.082 | -3 | 0.699 |
PKN2 |
0.787 | 0.024 | -3 | 0.797 |
TSSK2 |
0.786 | 0.044 | -5 | 0.867 |
TGFBR2 |
0.785 | -0.031 | -2 | 0.776 |
PDHK1 |
0.785 | -0.092 | 1 | 0.752 |
AMPKA2 |
0.785 | 0.051 | -3 | 0.775 |
GRK3 |
0.785 | 0.186 | -2 | 0.651 |
PLK1 |
0.784 | 0.148 | -2 | 0.774 |
NIK |
0.784 | 0.014 | -3 | 0.823 |
ALK2 |
0.784 | 0.155 | -2 | 0.786 |
BCKDK |
0.784 | -0.043 | -1 | 0.809 |
ICK |
0.784 | 0.072 | -3 | 0.822 |
MYLK4 |
0.784 | 0.115 | -2 | 0.786 |
ALK4 |
0.784 | 0.109 | -2 | 0.802 |
TSSK1 |
0.784 | 0.029 | -3 | 0.812 |
CK1E |
0.783 | 0.133 | -3 | 0.722 |
NLK |
0.783 | -0.046 | 1 | 0.695 |
ACVR2B |
0.783 | 0.137 | -2 | 0.766 |
WNK1 |
0.783 | -0.010 | -2 | 0.845 |
BRSK1 |
0.783 | 0.055 | -3 | 0.748 |
ACVR2A |
0.782 | 0.124 | -2 | 0.757 |
CDKL5 |
0.782 | 0.034 | -3 | 0.790 |
RIPK3 |
0.782 | -0.032 | 3 | 0.633 |
PAK1 |
0.781 | 0.094 | -2 | 0.802 |
PKCD |
0.781 | 0.028 | 2 | 0.790 |
CLK1 |
0.781 | 0.113 | -3 | 0.726 |
DYRK2 |
0.781 | 0.059 | 1 | 0.569 |
SRPK3 |
0.781 | 0.061 | -3 | 0.753 |
CAMK4 |
0.781 | 0.035 | -3 | 0.777 |
NEK6 |
0.780 | -0.080 | -2 | 0.817 |
CHAK2 |
0.780 | -0.014 | -1 | 0.855 |
AURB |
0.780 | 0.104 | -2 | 0.713 |
QSK |
0.780 | 0.020 | 4 | 0.389 |
ULK2 |
0.780 | -0.144 | 2 | 0.785 |
DRAK1 |
0.780 | 0.126 | 1 | 0.818 |
KIS |
0.779 | 0.001 | 1 | 0.529 |
MLK1 |
0.779 | -0.044 | 2 | 0.825 |
ERK5 |
0.779 | -0.038 | 1 | 0.624 |
MARK3 |
0.779 | 0.015 | 4 | 0.389 |
PLK3 |
0.778 | 0.101 | 2 | 0.781 |
NEK7 |
0.778 | -0.114 | -3 | 0.768 |
PKACA |
0.776 | 0.139 | -2 | 0.680 |
CAMK1G |
0.776 | 0.072 | -3 | 0.746 |
AKT2 |
0.776 | 0.101 | -3 | 0.694 |
SIK |
0.776 | 0.023 | -3 | 0.732 |
PRKD3 |
0.776 | 0.039 | -3 | 0.722 |
DNAPK |
0.776 | 0.073 | 1 | 0.626 |
CK1A2 |
0.776 | 0.155 | -3 | 0.690 |
ULK1 |
0.775 | -0.087 | -3 | 0.740 |
CK1D |
0.775 | 0.143 | -3 | 0.689 |
TLK2 |
0.775 | 0.054 | 1 | 0.756 |
CK1G1 |
0.775 | 0.127 | -3 | 0.722 |
RIPK1 |
0.775 | -0.039 | 1 | 0.741 |
MNK1 |
0.774 | 0.060 | -2 | 0.815 |
MASTL |
0.774 | -0.084 | -2 | 0.754 |
PKG2 |
0.774 | 0.080 | -2 | 0.716 |
DYRK4 |
0.773 | 0.078 | 1 | 0.490 |
MARK2 |
0.773 | -0.018 | 4 | 0.364 |
MNK2 |
0.773 | 0.032 | -2 | 0.809 |
HIPK2 |
0.772 | 0.051 | 1 | 0.480 |
MEK1 |
0.772 | 0.018 | 2 | 0.859 |
TTBK2 |
0.772 | -0.076 | 2 | 0.725 |
PAK3 |
0.771 | 0.028 | -2 | 0.788 |
ANKRD3 |
0.771 | -0.089 | 1 | 0.774 |
NUAK1 |
0.771 | -0.024 | -3 | 0.748 |
SGK3 |
0.770 | 0.072 | -3 | 0.734 |
NIM1 |
0.770 | -0.032 | 3 | 0.698 |
CDK8 |
0.770 | -0.029 | 1 | 0.526 |
MARK1 |
0.770 | -0.004 | 4 | 0.391 |
PKCA |
0.769 | -0.005 | 2 | 0.734 |
PKCB |
0.769 | -0.001 | 2 | 0.742 |
WNK3 |
0.769 | -0.184 | 1 | 0.724 |
PKCG |
0.769 | -0.022 | 2 | 0.749 |
PAK2 |
0.769 | 0.048 | -2 | 0.783 |
PKR |
0.768 | -0.011 | 1 | 0.744 |
DAPK1 |
0.768 | 0.173 | -3 | 0.776 |
CAMK1D |
0.768 | 0.099 | -3 | 0.655 |
BRSK2 |
0.767 | -0.044 | -3 | 0.756 |
QIK |
0.767 | -0.066 | -3 | 0.781 |
YSK4 |
0.767 | -0.036 | 1 | 0.720 |
PIM2 |
0.767 | 0.073 | -3 | 0.732 |
DCAMKL1 |
0.767 | 0.061 | -3 | 0.740 |
NEK9 |
0.767 | -0.132 | 2 | 0.836 |
MAPKAPK5 |
0.767 | 0.029 | -3 | 0.700 |
SMG1 |
0.767 | -0.015 | 1 | 0.689 |
CDK1 |
0.767 | -0.005 | 1 | 0.505 |
P70S6K |
0.767 | 0.096 | -3 | 0.697 |
MLK3 |
0.766 | -0.060 | 2 | 0.757 |
CHK1 |
0.766 | 0.010 | -3 | 0.734 |
PKCH |
0.766 | -0.005 | 2 | 0.719 |
PAK6 |
0.765 | 0.050 | -2 | 0.724 |
JNK3 |
0.765 | 0.018 | 1 | 0.507 |
HIPK1 |
0.765 | 0.039 | 1 | 0.575 |
DAPK3 |
0.765 | 0.119 | -3 | 0.778 |
SMMLCK |
0.765 | 0.081 | -3 | 0.791 |
MLK2 |
0.764 | -0.139 | 2 | 0.835 |
TLK1 |
0.764 | -0.026 | -2 | 0.790 |
MELK |
0.764 | -0.026 | -3 | 0.753 |
IRE1 |
0.764 | -0.120 | 1 | 0.693 |
CDK19 |
0.764 | -0.030 | 1 | 0.480 |
PLK2 |
0.763 | 0.106 | -3 | 0.686 |
VRK2 |
0.763 | -0.083 | 1 | 0.764 |
JNK2 |
0.763 | 0.015 | 1 | 0.476 |
MLK4 |
0.762 | -0.048 | 2 | 0.743 |
AKT1 |
0.762 | 0.079 | -3 | 0.699 |
CDK13 |
0.761 | -0.027 | 1 | 0.492 |
DYRK1A |
0.761 | 0.027 | 1 | 0.585 |
MEKK3 |
0.760 | 0.012 | 1 | 0.744 |
PKCZ |
0.760 | -0.038 | 2 | 0.784 |
CDK7 |
0.760 | -0.055 | 1 | 0.525 |
SSTK |
0.760 | -0.014 | 4 | 0.376 |
PHKG1 |
0.760 | -0.077 | -3 | 0.780 |
DYRK3 |
0.760 | 0.066 | 1 | 0.589 |
SGK1 |
0.759 | 0.123 | -3 | 0.629 |
CK1A |
0.759 | 0.181 | -3 | 0.620 |
CHAK1 |
0.758 | -0.120 | 2 | 0.784 |
BRAF |
0.757 | -0.045 | -4 | 0.830 |
MST3 |
0.757 | 0.001 | 2 | 0.854 |
DYRK1B |
0.757 | 0.020 | 1 | 0.506 |
DCAMKL2 |
0.757 | 0.010 | -3 | 0.754 |
NEK2 |
0.756 | -0.116 | 2 | 0.813 |
P38B |
0.755 | -0.012 | 1 | 0.461 |
GAK |
0.755 | 0.075 | 1 | 0.701 |
P38A |
0.754 | -0.043 | 1 | 0.526 |
CDK18 |
0.754 | -0.043 | 1 | 0.442 |
P38G |
0.754 | -0.026 | 1 | 0.404 |
TAO3 |
0.753 | -0.032 | 1 | 0.723 |
CDK12 |
0.753 | -0.033 | 1 | 0.469 |
ZAK |
0.753 | -0.109 | 1 | 0.738 |
SNRK |
0.753 | -0.130 | 2 | 0.685 |
CAMK1A |
0.752 | 0.063 | -3 | 0.646 |
AKT3 |
0.752 | 0.083 | -3 | 0.643 |
MEK5 |
0.752 | -0.140 | 2 | 0.836 |
CDK5 |
0.752 | -0.057 | 1 | 0.536 |
JNK1 |
0.752 | 0.025 | 1 | 0.470 |
PLK4 |
0.752 | -0.110 | 2 | 0.647 |
MRCKA |
0.752 | 0.106 | -3 | 0.725 |
IRE2 |
0.751 | -0.140 | 2 | 0.722 |
ERK1 |
0.751 | -0.035 | 1 | 0.450 |
PERK |
0.750 | -0.120 | -2 | 0.786 |
CDK9 |
0.750 | -0.049 | 1 | 0.493 |
CDK2 |
0.749 | -0.074 | 1 | 0.588 |
PAK4 |
0.749 | 0.065 | -2 | 0.690 |
WNK4 |
0.749 | -0.094 | -2 | 0.831 |
ERK2 |
0.749 | -0.048 | 1 | 0.502 |
PKCE |
0.749 | 0.025 | 2 | 0.726 |
CDK10 |
0.749 | 0.006 | 1 | 0.475 |
YANK3 |
0.749 | 0.052 | 2 | 0.449 |
GCK |
0.749 | 0.014 | 1 | 0.750 |
HIPK3 |
0.748 | -0.018 | 1 | 0.558 |
PKCT |
0.748 | -0.042 | 2 | 0.731 |
HRI |
0.748 | -0.171 | -2 | 0.798 |
MPSK1 |
0.748 | -0.035 | 1 | 0.653 |
MEKK1 |
0.748 | -0.157 | 1 | 0.726 |
PHKG2 |
0.747 | -0.077 | -3 | 0.752 |
SBK |
0.747 | 0.092 | -3 | 0.583 |
MEKK2 |
0.747 | -0.102 | 2 | 0.809 |
CDK17 |
0.747 | -0.052 | 1 | 0.406 |
PAK5 |
0.747 | 0.034 | -2 | 0.671 |
CHK2 |
0.747 | 0.041 | -3 | 0.634 |
TTBK1 |
0.747 | -0.081 | 2 | 0.642 |
NEK11 |
0.746 | -0.109 | 1 | 0.738 |
P38D |
0.746 | -0.009 | 1 | 0.398 |
CAMKK2 |
0.746 | -0.022 | -2 | 0.716 |
CAMKK1 |
0.746 | -0.083 | -2 | 0.713 |
CDK3 |
0.746 | -0.031 | 1 | 0.423 |
PRP4 |
0.745 | -0.070 | -3 | 0.670 |
MRCKB |
0.745 | 0.066 | -3 | 0.717 |
CDK14 |
0.745 | -0.038 | 1 | 0.488 |
TAK1 |
0.745 | 0.011 | 1 | 0.790 |
MAK |
0.745 | 0.065 | -2 | 0.768 |
PKCI |
0.744 | -0.022 | 2 | 0.751 |
ROCK2 |
0.744 | 0.075 | -3 | 0.755 |
NEK5 |
0.744 | -0.163 | 1 | 0.720 |
EEF2K |
0.744 | -0.006 | 3 | 0.734 |
MST2 |
0.743 | -0.040 | 1 | 0.744 |
NEK8 |
0.743 | -0.119 | 2 | 0.813 |
PINK1 |
0.741 | -0.185 | 1 | 0.702 |
PDK1 |
0.741 | -0.054 | 1 | 0.714 |
HPK1 |
0.740 | -0.012 | 1 | 0.735 |
CRIK |
0.740 | 0.115 | -3 | 0.702 |
DMPK1 |
0.740 | 0.092 | -3 | 0.739 |
BUB1 |
0.740 | 0.038 | -5 | 0.810 |
PKN1 |
0.738 | -0.010 | -3 | 0.703 |
PDHK3_TYR |
0.738 | 0.297 | 4 | 0.488 |
CDK16 |
0.738 | -0.052 | 1 | 0.416 |
TAO2 |
0.737 | -0.132 | 2 | 0.842 |
LKB1 |
0.737 | -0.107 | -3 | 0.737 |
IRAK4 |
0.737 | -0.180 | 1 | 0.690 |
MAP3K15 |
0.736 | -0.130 | 1 | 0.701 |
MST1 |
0.735 | -0.065 | 1 | 0.718 |
MINK |
0.735 | -0.086 | 1 | 0.719 |
MOK |
0.735 | 0.034 | 1 | 0.577 |
PDHK4_TYR |
0.735 | 0.230 | 2 | 0.888 |
TNIK |
0.735 | -0.077 | 3 | 0.759 |
LRRK2 |
0.734 | -0.098 | 2 | 0.844 |
VRK1 |
0.734 | -0.109 | 2 | 0.832 |
ALPHAK3 |
0.734 | 0.096 | -1 | 0.784 |
STK33 |
0.733 | -0.057 | 2 | 0.653 |
KHS2 |
0.733 | -0.015 | 1 | 0.724 |
HGK |
0.731 | -0.103 | 3 | 0.752 |
SLK |
0.731 | -0.060 | -2 | 0.657 |
KHS1 |
0.731 | -0.054 | 1 | 0.702 |
ROCK1 |
0.730 | 0.058 | -3 | 0.722 |
MAP2K6_TYR |
0.730 | 0.195 | -1 | 0.876 |
ERK7 |
0.730 | -0.039 | 2 | 0.560 |
NEK4 |
0.729 | -0.183 | 1 | 0.691 |
CK1G3 |
0.729 | 0.137 | -3 | 0.582 |
MEKK6 |
0.729 | -0.186 | 1 | 0.701 |
IRAK1 |
0.729 | -0.239 | -1 | 0.721 |
BMPR2_TYR |
0.728 | 0.136 | -1 | 0.865 |
PKG1 |
0.728 | 0.023 | -2 | 0.653 |
LOK |
0.726 | -0.105 | -2 | 0.721 |
NEK1 |
0.725 | -0.160 | 1 | 0.694 |
RIPK2 |
0.725 | -0.164 | 1 | 0.697 |
MAP2K4_TYR |
0.725 | 0.080 | -1 | 0.873 |
PDHK1_TYR |
0.723 | 0.064 | -1 | 0.876 |
OSR1 |
0.723 | -0.073 | 2 | 0.831 |
TESK1_TYR |
0.723 | -0.038 | 3 | 0.799 |
MEK2 |
0.722 | -0.192 | 2 | 0.821 |
CDK4 |
0.721 | -0.064 | 1 | 0.454 |
YSK1 |
0.721 | -0.129 | 2 | 0.811 |
MAP2K7_TYR |
0.720 | -0.046 | 2 | 0.859 |
TTK |
0.719 | -0.084 | -2 | 0.796 |
CDK6 |
0.718 | -0.082 | 1 | 0.456 |
PBK |
0.718 | -0.092 | 1 | 0.583 |
CK1G2 |
0.718 | 0.128 | -3 | 0.655 |
HASPIN |
0.718 | -0.035 | -1 | 0.693 |
PKMYT1_TYR |
0.716 | -0.086 | 3 | 0.765 |
PINK1_TYR |
0.716 | -0.076 | 1 | 0.756 |
EPHA6 |
0.714 | -0.035 | -1 | 0.844 |
YANK2 |
0.712 | 0.024 | 2 | 0.460 |
ASK1 |
0.712 | -0.142 | 1 | 0.698 |
EPHA4 |
0.712 | 0.039 | 2 | 0.791 |
EPHB4 |
0.711 | -0.015 | -1 | 0.830 |
DDR1 |
0.710 | -0.067 | 4 | 0.442 |
LIMK2_TYR |
0.709 | -0.100 | -3 | 0.803 |
BIKE |
0.708 | -0.077 | 1 | 0.545 |
TXK |
0.708 | 0.026 | 1 | 0.823 |
RET |
0.707 | -0.157 | 1 | 0.709 |
MYO3B |
0.706 | -0.133 | 2 | 0.822 |
TAO1 |
0.704 | -0.148 | 1 | 0.653 |
MYO3A |
0.704 | -0.148 | 1 | 0.704 |
SRMS |
0.704 | -0.006 | 1 | 0.817 |
EPHB1 |
0.703 | -0.016 | 1 | 0.806 |
INSRR |
0.703 | -0.057 | 3 | 0.624 |
LIMK1_TYR |
0.703 | -0.206 | 2 | 0.845 |
NEK3 |
0.702 | -0.244 | 1 | 0.653 |
MST1R |
0.702 | -0.208 | 3 | 0.696 |
STLK3 |
0.702 | -0.147 | 1 | 0.702 |
ABL2 |
0.701 | -0.103 | -1 | 0.795 |
FER |
0.700 | -0.131 | 1 | 0.793 |
CSF1R |
0.700 | -0.173 | 3 | 0.675 |
EPHB2 |
0.700 | -0.030 | -1 | 0.805 |
FGR |
0.699 | -0.129 | 1 | 0.730 |
JAK3 |
0.699 | -0.147 | 1 | 0.716 |
TYK2 |
0.699 | -0.246 | 1 | 0.703 |
SYK |
0.698 | 0.089 | -1 | 0.766 |
KIT |
0.698 | -0.122 | 3 | 0.686 |
TYRO3 |
0.697 | -0.227 | 3 | 0.673 |
EPHB3 |
0.697 | -0.064 | -1 | 0.808 |
DDR2 |
0.696 | 0.037 | 3 | 0.611 |
EPHA3 |
0.696 | -0.039 | 2 | 0.763 |
ABL1 |
0.696 | -0.118 | -1 | 0.782 |
FGFR2 |
0.696 | -0.136 | 3 | 0.696 |
EPHA7 |
0.696 | -0.033 | 2 | 0.789 |
JAK2 |
0.696 | -0.232 | 1 | 0.696 |
NEK10_TYR |
0.695 | -0.097 | 1 | 0.617 |
ROS1 |
0.695 | -0.248 | 3 | 0.631 |
ITK |
0.695 | -0.097 | -1 | 0.763 |
BMX |
0.695 | -0.029 | -1 | 0.710 |
YES1 |
0.695 | -0.123 | -1 | 0.801 |
FLT1 |
0.695 | -0.035 | -1 | 0.832 |
PTK2 |
0.695 | 0.063 | -1 | 0.769 |
EPHA5 |
0.695 | 0.022 | 2 | 0.775 |
TNK2 |
0.694 | -0.107 | 3 | 0.641 |
MET |
0.693 | -0.120 | 3 | 0.670 |
KDR |
0.692 | -0.139 | 3 | 0.636 |
MERTK |
0.692 | -0.096 | 3 | 0.670 |
AAK1 |
0.692 | -0.053 | 1 | 0.422 |
PDGFRB |
0.692 | -0.191 | 3 | 0.682 |
WEE1_TYR |
0.691 | -0.075 | -1 | 0.756 |
NTRK1 |
0.691 | -0.096 | -1 | 0.824 |
TEC |
0.690 | -0.096 | -1 | 0.703 |
PTK2B |
0.690 | -0.014 | -1 | 0.734 |
FLT3 |
0.690 | -0.196 | 3 | 0.672 |
ERBB2 |
0.689 | -0.116 | 1 | 0.701 |
FYN |
0.689 | -0.050 | -1 | 0.757 |
FGFR3 |
0.688 | -0.105 | 3 | 0.663 |
HCK |
0.688 | -0.183 | -1 | 0.780 |
EGFR |
0.688 | -0.039 | 1 | 0.629 |
AXL |
0.687 | -0.155 | 3 | 0.661 |
FGFR1 |
0.686 | -0.192 | 3 | 0.649 |
LCK |
0.686 | -0.160 | -1 | 0.784 |
BLK |
0.685 | -0.125 | -1 | 0.782 |
JAK1 |
0.685 | -0.170 | 1 | 0.664 |
FLT4 |
0.685 | -0.135 | 3 | 0.647 |
EPHA8 |
0.685 | -0.047 | -1 | 0.786 |
TNNI3K_TYR |
0.684 | -0.160 | 1 | 0.692 |
TNK1 |
0.684 | -0.187 | 3 | 0.663 |
PDGFRA |
0.684 | -0.243 | 3 | 0.679 |
TEK |
0.683 | -0.226 | 3 | 0.608 |
PTK6 |
0.683 | -0.160 | -1 | 0.715 |
LTK |
0.683 | -0.146 | 3 | 0.622 |
ALK |
0.683 | -0.185 | 3 | 0.587 |
INSR |
0.682 | -0.151 | 3 | 0.598 |
BTK |
0.682 | -0.202 | -1 | 0.730 |
FRK |
0.682 | -0.140 | -1 | 0.793 |
NTRK3 |
0.682 | -0.100 | -1 | 0.786 |
MATK |
0.682 | -0.100 | -1 | 0.741 |
CSK |
0.680 | -0.079 | 2 | 0.788 |
EPHA2 |
0.680 | -0.025 | -1 | 0.770 |
FGFR4 |
0.680 | -0.060 | -1 | 0.772 |
NTRK2 |
0.679 | -0.182 | 3 | 0.645 |
EPHA1 |
0.679 | -0.171 | 3 | 0.639 |
ERBB4 |
0.678 | -0.027 | 1 | 0.676 |
LYN |
0.675 | -0.169 | 3 | 0.608 |
IGF1R |
0.672 | -0.103 | 3 | 0.548 |
SRC |
0.672 | -0.121 | -1 | 0.754 |
ZAP70 |
0.664 | -0.018 | -1 | 0.708 |
MUSK |
0.664 | -0.146 | 1 | 0.599 |
FES |
0.660 | -0.084 | -1 | 0.686 |