Motif 521 (n=194)

Position-wise Probabilities
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uniprot genes site source protein function
A3KN83 SBNO1 S811 ochoa Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}.
A6NKT7 RGPD3 S793 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A6NKT7 RGPD3 S1591 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O14639 ABLIM1 S363 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O14647 CHD2 S1785 ochoa Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.
O14686 KMT2D S1858 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14715 RGPD8 S1590 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O14920 IKBKB S679 ochoa Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
O15075 DCLK1 S330 ochoa Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
O15439 ABCC4 S661 ochoa ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}.
O15553 MEFV S345 ochoa Pyrin (Marenostrin) Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250|UniProtKB:Q9JJ26, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446, ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:27030597, ECO:0000269|PubMed:28835462}.
O43399 TPD52L2 S145 ochoa Tumor protein D54 (hD54) (Tumor protein D52-like 2) None
O43474 KLF4 S240 ochoa Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}.
O43524 FOXO3 S421 ochoa Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O43524 FOXO3 S425 ochoa|psp Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O43524 FOXO3 S432 ochoa Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O43623 SNAI2 S100 psp Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.
O60271 SPAG9 S238 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60307 MAST3 S43 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60346 PHLPP1 S317 ochoa|psp PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.
O75122 CLASP2 S459 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75122 CLASP2 S503 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75376 NCOR1 Y2147 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75427 LRCH4 S517 ochoa Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.
O75962 TRIO S2455 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
O75962 TRIO S2488 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
O75995 SASH3 S142 ochoa SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}.
O76080 ZFAND5 S54 ochoa AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}.
O94972 TRIM37 S801 ochoa E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}.
O95049 TJP3 S323 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95684 CEP43 S156 ochoa Centrosomal protein 43 (FGFR1 oncogene partner) Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
O95817 BAG3 S177 ochoa BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}.
O95863 SNAI1 S100 psp Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}.
P02671 FGA S281 ochoa Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P0DJD0 RGPD1 S783 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD0 RGPD1 S1575 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S791 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DJD1 RGPD2 S1583 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10071 GLI3 S660 ochoa Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.
P10636 MAPT S512 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P10636 MAPT S717 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11137 MAP2 S1786 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11274 BCR S367 ochoa Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}.
P12270 TPR S2054 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P13807 GYS1 S649 ochoa|psp Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}.
P17661 DES S28 ochoa|psp Desmin Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.
P19484 TFEB S138 ochoa|psp Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.
P19838 NFKB1 S903 ochoa|psp Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}.
P30291 WEE1 Y132 ochoa Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}.
P35222 CTNNB1 S33 psp Catenin beta-1 (Beta-catenin) Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}.
P35568 IRS1 S341 ochoa Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P35611 ADD1 S427 ochoa Alpha-adducin (Erythrocyte adducin subunit alpha) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
P46821 MAP1B S1258 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P49792 RANBP2 S792 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2566 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49815 TSC2 S1379 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P56524 HDAC4 S632 ochoa|psp Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P57682 KLF3 S74 ochoa Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
P78310 CXADR S293 ochoa|psp Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.
P78310 CXADR S297 ochoa Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.
P78559 MAP1A S1214 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559 MAP1A S1322 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q00536 CDK16 S82 ochoa|psp Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
Q01082 SPTBN1 S2165 ochoa Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
Q03164 KMT2A S3511 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04656 ATP7A S353 ochoa Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}.
Q08495 DMTN S22 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q09666 AHNAK S212 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S216 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S5735 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12797 ASPH S20 ochoa Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}.
Q12888 TP53BP1 S1642 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13191 CBLB S525 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13247 SRSF6 S299 ochoa Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}.
Q13409 DYNC1I2 S97 ochoa Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}.
Q13428 TCOF1 S160 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13501 SQSTM1 S287 ochoa Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13905 RAPGEF1 S345 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q14162 SCARF1 S749 ochoa Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}.
Q14244 MAP7 S165 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14687 GSE1 S80 ochoa Genetic suppressor element 1 None
Q14687 GSE1 T91 ochoa Genetic suppressor element 1 None
Q15746 MYLK S1772 ochoa|psp Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q16204 CCDC6 S363 ochoa Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) None
Q16204 CCDC6 S367 ochoa Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) None
Q16566 CAMK4 S356 ochoa Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}.
Q2LD37 BLTP1 S4304 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q4G0J3 LARP7 S254 ochoa La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.
Q504U0 C4orf46 S26 ochoa Renal cancer differentiation gene 1 protein None
Q53GS7 GLE1 S92 ochoa|psp mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.
Q53H80 AKIRIN2 S121 ochoa Akirin-2 Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}.
Q5T200 ZC3H13 S329 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5THJ4 VPS13D S1038 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5VT52 RPRD2 S610 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q63HR2 TNS2 S996 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q658Y4 FAM91A1 T351 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q659A1 ICE2 S601 ochoa Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}.
Q68CZ2 TNS3 S683 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68CZ2 TNS3 S1119 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68EM7 ARHGAP17 S610 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6GQQ9 OTUD7B S453 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6GQQ9 OTUD7B S471 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6H8Q1 ABLIM2 S290 ochoa Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
Q6JBY9 RCSD1 S116 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6P3S6 FBXO42 S583 ochoa F-box only protein 42 (Just one F-box and Kelch domain-containing protein) Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.
Q6P996 PDXDC1 S714 ochoa Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) None
Q6R327 RICTOR S1581 ochoa Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}.
Q6UXY1 BAIAP2L2 S227 ochoa BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.
Q6VN20 RANBP10 S365 ochoa Ran-binding protein 10 (RanBP10) May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q6ZNJ1 NBEAL2 S1305 ochoa Neurobeachin-like protein 2 Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.
Q6ZUT6 CCDC9B S407 ochoa Coiled-coil domain-containing protein 9B None
Q7Z3B3 KANSL1 S984 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z3J3 RGPD4 S793 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z3J3 RGPD4 S1591 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q86UU0 BCL9L S938 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86VP3 PACS2 S702 ochoa Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}.
Q86X29 LSR S508 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q86YD5 LDLRAD3 S309 ochoa Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}.
Q8IX07 ZFPM1 S487 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IYB3 SRRM1 S777 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IZD2 KMT2E S1355 ochoa Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.
Q8IZH2 XRN1 S1649 ochoa 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}.
Q8IZP0 ABI1 S319 ochoa Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q8N122 RPTOR S859 ochoa|psp Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}.
Q8ND30 PPFIBP2 S483 ochoa Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q8NEM7 SUPT20H S430 ochoa Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}.
Q8NHM5 KDM2B S828 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8TAP9 MPLKIP S97 ochoa M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
Q8TBP0 TBC1D16 S122 ochoa TBC1 domain family member 16 May act as a GTPase-activating protein for Rab family protein(s).
Q8TDJ6 DMXL2 S949 ochoa DmX-like protein 2 (Rabconnectin-3) May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
Q8TEM1 NUP210 S1859 ochoa Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.
Q8TF72 SHROOM3 S974 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WUM0 NUP133 S41 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WX93 PALLD S759 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WYP5 AHCTF1 S1138 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92610 ZNF592 S687 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q96CP6 GRAMD1A S267 ochoa Protein Aster-A (GRAM domain-containing protein 1A) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.
Q96HC4 PDLIM5 S383 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96JM3 CHAMP1 S472 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96JY6 PDLIM2 S120 ochoa PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
Q96PD2 DCBLD2 S720 ochoa|psp Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) None
Q96SI1 KCTD15 S31 ochoa BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15) During embryonic development, it is involved in neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain (PubMed:23382213). {ECO:0000250|UniProtKB:Q6DC02, ECO:0000269|PubMed:23382213}.
Q99666 RGPD5 S1590 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99700 ATXN2 S554 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q99700 ATXN2 S861 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q99959 PKP2 S293 ochoa Plakophilin-2 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}.
Q9BQE9 BCL7B S118 ochoa B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.
Q9BX40 LSM14B S102 ochoa Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}.
Q9BXS6 NUSAP1 S247 ochoa Nucleolar and spindle-associated protein 1 (NuSAP) Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}.
Q9BXS6 NUSAP1 S251 ochoa Nucleolar and spindle-associated protein 1 (NuSAP) Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}.
Q9BZQ8 NIBAN1 S592 ochoa Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9C0B5 ZDHHC5 S391 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0C2 TNKS1BP1 S297 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0H2 TTYH3 S496 ochoa Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q6P5F7, ECO:0000269|PubMed:15010458}.
Q9GZV5 WWTR1 S307 ochoa WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}.
Q9H1A4 ANAPC1 S518 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H1K0 RBSN S215 ochoa|psp Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
Q9H1K0 RBSN S226 ochoa Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
Q9H6S0 YTHDC2 S1263 ochoa 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}.
Q9H6S3 EPS8L2 S459 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9H7D0 DOCK5 S1785 ochoa Dedicator of cytokinesis protein 5 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.
Q9NP08 HMX1 S133 ochoa Homeobox protein HMX1 (Homeobox protein H6) DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269|PubMed:10206974}.
Q9NQC7 CYLD S432 psp Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}.
Q9NYF8 BCLAF1 S272 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NYV4 CDK12 S261 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9NYV4 CDK12 S287 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9NYV4 CDK12 S316 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9NZN8 CNOT2 S161 ochoa CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Q9P0K1 ADAM22 S862 ochoa Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.
Q9P0K1 ADAM22 S866 ochoa Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.
Q9P0K7 RAI14 S286 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P206 NHSL3 S566 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9UBC2 EPS15L1 S246 ochoa Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.
Q9UBW5 BIN2 S259 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UBW5 BIN2 S273 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UBW5 BIN2 S429 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UBW5 BIN2 S440 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UDT6 CLIP2 S156 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UHV7 MED13 S2022 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UI08 EVL S345 ochoa Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Q9UJF2 RASAL2 S950 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UKI8 TLK1 S174 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9UPA5 BSN S1488 ochoa Protein bassoon (Zinc finger protein 231) Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.
Q9UPN3 MACF1 S7226 psp Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPN3 MACF1 S7230 ochoa|psp Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UQ35 SRRM2 S950 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1383 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1451 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2417 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2W1 THRAP3 S306 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y2X7 GIT1 S581 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y5K6 CD2AP S546 ochoa CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.
Q9Y5S2 CDC42BPB S1686 ochoa|psp Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q96EP5 DAZAP1 S204 Sugiyama DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) RNA-binding protein, which may be required during spermatogenesis.
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reactome_id name p -log10_p
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.000034 4.463
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.000066 4.178
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000696 3.158
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000770 3.114
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000770 3.114
R-HSA-1855170 IPs transport between nucleus and cytosol 0.000934 3.029
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.000934 3.029
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.001025 2.989
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.001226 2.912
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.001706 2.768
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.001843 2.734
R-HSA-209560 NF-kB is activated and signals survival 0.000630 3.201
R-HSA-69618 Mitotic Spindle Checkpoint 0.001458 2.836
R-HSA-193639 p75NTR signals via NF-kB 0.001239 2.907
R-HSA-9675151 Disorders of Developmental Biology 0.001647 2.783
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.001452 2.838
R-HSA-418885 DCC mediated attractive signaling 0.001239 2.907
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.001025 2.989
R-HSA-180746 Nuclear import of Rev protein 0.001122 2.950
R-HSA-177243 Interactions of Rev with host cellular proteins 0.001843 2.734
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.001843 2.734
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.001575 2.803
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.001706 2.768
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.000830 3.081
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.001989 2.701
R-HSA-9609690 HCMV Early Events 0.002623 2.581
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.002835 2.547
R-HSA-73887 Death Receptor Signaling 0.002956 2.529
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.003029 2.519
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.003338 2.476
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.003549 2.450
R-HSA-5603029 IkBA variant leads to EDA-ID 0.003549 2.450
R-HSA-3371556 Cellular response to heat stress 0.003817 2.418
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.003860 2.413
R-HSA-141424 Amplification of signal from the kinetochores 0.003860 2.413
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.004072 2.390
R-HSA-2980766 Nuclear Envelope Breakdown 0.005803 2.236
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.005813 2.236
R-HSA-191859 snRNP Assembly 0.006443 2.191
R-HSA-194441 Metabolism of non-coding RNA 0.006443 2.191
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.006596 2.181
R-HSA-168325 Viral Messenger RNA Synthesis 0.007128 2.147
R-HSA-193704 p75 NTR receptor-mediated signalling 0.007382 2.132
R-HSA-6784531 tRNA processing in the nucleus 0.007488 2.126
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.007762 2.110
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.008230 2.085
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.008243 2.084
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.008534 2.069
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.009046 2.044
R-HSA-9609646 HCMV Infection 0.009877 2.005
R-HSA-4839726 Chromatin organization 0.009674 2.014
R-HSA-162582 Signal Transduction 0.010529 1.978
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.016739 1.776
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.012639 1.898
R-HSA-2467813 Separation of Sister Chromatids 0.015184 1.819
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.015904 1.799
R-HSA-5260271 Diseases of Immune System 0.015047 1.823
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.015047 1.823
R-HSA-209543 p75NTR recruits signalling complexes 0.013414 1.872
R-HSA-9005895 Pervasive developmental disorders 0.013414 1.872
R-HSA-9697154 Disorders of Nervous System Development 0.013414 1.872
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.013414 1.872
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.011167 1.952
R-HSA-8853884 Transcriptional Regulation by VENTX 0.015904 1.799
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.016598 1.780
R-HSA-5578749 Transcriptional regulation by small RNAs 0.011758 1.930
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.010819 1.966
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.011274 1.948
R-HSA-3214841 PKMTs methylate histone lysines 0.015904 1.799
R-HSA-8941326 RUNX2 regulates bone development 0.011890 1.925
R-HSA-74160 Gene expression (Transcription) 0.015003 1.824
R-HSA-69620 Cell Cycle Checkpoints 0.011610 1.935
R-HSA-1169408 ISG15 antiviral mechanism 0.013290 1.876
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.011804 1.928
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.017221 1.764
R-HSA-9006925 Intracellular signaling by second messengers 0.018196 1.740
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.018520 1.732
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.021502 1.668
R-HSA-9673013 Diseases of Telomere Maintenance 0.021502 1.668
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.021502 1.668
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.021502 1.668
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.021502 1.668
R-HSA-5357905 Regulation of TNFR1 signaling 0.021609 1.665
R-HSA-373752 Netrin-1 signaling 0.019599 1.708
R-HSA-75153 Apoptotic execution phase 0.021609 1.665
R-HSA-3247509 Chromatin modifying enzymes 0.021840 1.661
R-HSA-1257604 PIP3 activates AKT signaling 0.022647 1.645
R-HSA-9843745 Adipogenesis 0.022943 1.639
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.026385 1.579
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.026385 1.579
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.032080 1.494
R-HSA-5602636 IKBKB deficiency causes SCID 0.032080 1.494
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.033016 1.481
R-HSA-75893 TNF signaling 0.033286 1.478
R-HSA-68877 Mitotic Prometaphase 0.029226 1.534
R-HSA-373753 Nephrin family interactions 0.030740 1.512
R-HSA-68886 M Phase 0.033026 1.481
R-HSA-8878159 Transcriptional regulation by RUNX3 0.031020 1.508
R-HSA-844456 The NLRP3 inflammasome 0.028529 1.545
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.031393 1.503
R-HSA-70171 Glycolysis 0.033775 1.471
R-HSA-1266738 Developmental Biology 0.035023 1.456
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.035944 1.444
R-HSA-429914 Deadenylation-dependent mRNA decay 0.037313 1.428
R-HSA-9860931 Response of endothelial cells to shear stress 0.037663 1.424
R-HSA-350054 Notch-HLH transcription pathway 0.037759 1.423
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.037759 1.423
R-HSA-8943724 Regulation of PTEN gene transcription 0.038708 1.412
R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.042544 1.371
R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.042544 1.371
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.047960 1.319
R-HSA-933542 TRAF6 mediated NF-kB activation 0.042744 1.369
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.040727 1.390
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.047960 1.319
R-HSA-525793 Myogenesis 0.047960 1.319
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.050808 1.294
R-HSA-68882 Mitotic Anaphase 0.045209 1.345
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.045974 1.337
R-HSA-9610379 HCMV Late Events 0.043297 1.364
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.050808 1.294
R-HSA-429947 Deadenylation of mRNA 0.042744 1.369
R-HSA-1483249 Inositol phosphate metabolism 0.047313 1.325
R-HSA-9855142 Cellular responses to mechanical stimuli 0.049628 1.304
R-HSA-8953897 Cellular responses to stimuli 0.050769 1.294
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.041797 1.379
R-HSA-9700206 Signaling by ALK in cancer 0.041797 1.379
R-HSA-211000 Gene Silencing by RNA 0.041797 1.379
R-HSA-73857 RNA Polymerase II Transcription 0.051245 1.290
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.052896 1.277
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.052896 1.277
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.063136 1.200
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.063136 1.200
R-HSA-74713 IRS activation 0.073267 1.135
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.073267 1.135
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.073267 1.135
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.083288 1.079
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.083288 1.079
R-HSA-8951430 RUNX3 regulates WNT signaling 0.103009 0.987
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.103009 0.987
R-HSA-112412 SOS-mediated signalling 0.103009 0.987
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.112710 0.948
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.141194 0.850
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.150484 0.823
R-HSA-5339716 Signaling by GSK3beta mutants 0.150484 0.823
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.159675 0.797
R-HSA-3000484 Scavenging by Class F Receptors 0.159675 0.797
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.159675 0.797
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.159675 0.797
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.159675 0.797
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.159675 0.797
R-HSA-9027284 Erythropoietin activates RAS 0.186659 0.729
R-HSA-196299 Beta-catenin phosphorylation cascade 0.186659 0.729
R-HSA-390522 Striated Muscle Contraction 0.070893 1.149
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.195461 0.709
R-HSA-176412 Phosphorylation of the APC/C 0.195461 0.709
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.195461 0.709
R-HSA-72187 mRNA 3'-end processing 0.139100 0.857
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.180855 0.743
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.180855 0.743
R-HSA-8854518 AURKA Activation by TPX2 0.192554 0.715
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.196027 0.708
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.196027 0.708
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.196027 0.708
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.073267 1.135
R-HSA-9762292 Regulation of CDH11 function 0.131802 0.880
R-HSA-198203 PI3K/AKT activation 0.131802 0.880
R-HSA-5682910 LGI-ADAM interactions 0.141194 0.850
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.083288 1.079
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.204168 0.690
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.120922 0.917
R-HSA-1169091 Activation of NF-kappaB in B cells 0.135417 0.868
R-HSA-9614085 FOXO-mediated transcription 0.118925 0.925
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 0.112710 0.948
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.141194 0.850
R-HSA-9675126 Diseases of mitotic cell cycle 0.064872 1.188
R-HSA-1839124 FGFR1 mutant receptor activation 0.067860 1.168
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.177762 0.750
R-HSA-9758274 Regulation of NF-kappa B signaling 0.195461 0.709
R-HSA-8875513 MET interacts with TNS proteins 0.052896 1.277
R-HSA-69478 G2/M DNA replication checkpoint 0.093202 1.031
R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.131802 0.880
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.168768 0.773
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.204168 0.690
R-HSA-5655302 Signaling by FGFR1 in disease 0.099995 1.000
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.177004 0.752
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.208300 0.681
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.131802 0.880
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.177004 0.752
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.185093 0.733
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.185093 0.733
R-HSA-165159 MTOR signalling 0.103407 0.985
R-HSA-9020702 Interleukin-1 signaling 0.123655 0.908
R-HSA-74749 Signal attenuation 0.131802 0.880
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.059036 1.229
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.103009 0.987
R-HSA-8875555 MET activates RAP1 and RAC1 0.131802 0.880
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.168768 0.773
R-HSA-212165 Epigenetic regulation of gene expression 0.171879 0.765
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 0.093202 1.031
R-HSA-8964046 VLDL clearance 0.103009 0.987
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.122308 0.913
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.150484 0.823
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.186659 0.729
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.204168 0.690
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.204168 0.690
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.056190 1.250
R-HSA-9664873 Pexophagy 0.131802 0.880
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.067860 1.168
R-HSA-9842663 Signaling by LTK 0.159675 0.797
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.093202 1.031
R-HSA-205043 NRIF signals cell death from the nucleus 0.177762 0.750
R-HSA-114608 Platelet degranulation 0.201552 0.696
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.113830 0.944
R-HSA-438064 Post NMDA receptor activation events 0.087883 1.056
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.163755 0.786
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.073267 1.135
R-HSA-5660668 CLEC7A/inflammasome pathway 0.083288 1.079
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.103009 0.987
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.122308 0.913
R-HSA-8951936 RUNX3 regulates p14-ARF 0.159675 0.797
R-HSA-937039 IRAK1 recruits IKK complex 0.159675 0.797
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.159675 0.797
R-HSA-9796292 Formation of axial mesoderm 0.168768 0.773
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.186659 0.729
R-HSA-8875878 MET promotes cell motility 0.086684 1.062
R-HSA-73856 RNA Polymerase II Transcription Termination 0.173118 0.762
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.207195 0.684
R-HSA-9659379 Sensory processing of sound 0.070054 1.155
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.159675 0.797
R-HSA-450294 MAP kinase activation 0.173118 0.762
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.157791 0.802
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.157791 0.802
R-HSA-9022692 Regulation of MECP2 expression and activity 0.067860 1.168
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.073267 1.135
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.083288 1.079
R-HSA-193692 Regulated proteolysis of p75NTR 0.122308 0.913
R-HSA-448706 Interleukin-1 processing 0.122308 0.913
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.141194 0.850
R-HSA-8851805 MET activates RAS signaling 0.159675 0.797
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.177762 0.750
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.186659 0.729
R-HSA-448424 Interleukin-17 signaling 0.208300 0.681
R-HSA-168898 Toll-like Receptor Cascades 0.196081 0.708
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.056938 1.245
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.064872 1.188
R-HSA-1500931 Cell-Cell communication 0.161032 0.793
R-HSA-69278 Cell Cycle, Mitotic 0.108502 0.965
R-HSA-1632852 Macroautophagy 0.094798 1.023
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.059193 1.228
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.154039 0.812
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.117362 0.930
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.117362 0.930
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.083288 1.079
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.112710 0.948
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.053395 1.273
R-HSA-5578768 Physiological factors 0.177762 0.750
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.177762 0.750
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.186659 0.729
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.195461 0.709
R-HSA-1640170 Cell Cycle 0.101398 0.994
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.126045 0.899
R-HSA-170968 Frs2-mediated activation 0.168768 0.773
R-HSA-397014 Muscle contraction 0.110224 0.958
R-HSA-9612973 Autophagy 0.122726 0.911
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.131802 0.880
R-HSA-8854214 TBC/RABGAPs 0.106851 0.971
R-HSA-193648 NRAGE signals death through JNK 0.154039 0.812
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.120886 0.918
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.054088 1.267
R-HSA-5683057 MAPK family signaling cascades 0.211223 0.675
R-HSA-212436 Generic Transcription Pathway 0.132299 0.878
R-HSA-202403 TCR signaling 0.148278 0.829
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.096615 1.015
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.154039 0.812
R-HSA-936837 Ion transport by P-type ATPases 0.184743 0.733
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.161899 0.791
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.159675 0.797
R-HSA-5223345 Miscellaneous transport and binding events 0.070893 1.149
R-HSA-168638 NOD1/2 Signaling Pathway 0.073969 1.131
R-HSA-622312 Inflammasomes 0.053395 1.273
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.054088 1.267
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.155752 0.808
R-HSA-9730414 MITF-M-regulated melanocyte development 0.111695 0.952
R-HSA-2586552 Signaling by Leptin 0.131802 0.880
R-HSA-169893 Prolonged ERK activation events 0.195461 0.709
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.112710 0.948
R-HSA-9711123 Cellular response to chemical stress 0.205623 0.687
R-HSA-6806834 Signaling by MET 0.071945 1.143
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.169270 0.771
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.107410 0.969
R-HSA-162909 Host Interactions of HIV factors 0.064796 1.188
R-HSA-2262752 Cellular responses to stress 0.101664 0.993
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.077088 1.113
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.187811 0.726
R-HSA-168255 Influenza Infection 0.170230 0.769
R-HSA-983712 Ion channel transport 0.191689 0.717
R-HSA-388841 Regulation of T cell activation by CD28 family 0.183179 0.737
R-HSA-9705683 SARS-CoV-2-host interactions 0.134860 0.870
R-HSA-9762293 Regulation of CDH11 gene transcription 0.122308 0.913
R-HSA-8878166 Transcriptional regulation by RUNX2 0.177004 0.752
R-HSA-68875 Mitotic Prophase 0.059497 1.226
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.128121 0.892
R-HSA-70326 Glucose metabolism 0.055682 1.254
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.169270 0.771
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.169270 0.771
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.169270 0.771
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.169270 0.771
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.182386 0.739
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.166380 0.779
R-HSA-194138 Signaling by VEGF 0.196027 0.708
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.169270 0.771
R-HSA-162599 Late Phase of HIV Life Cycle 0.098107 1.008
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.157821 0.802
R-HSA-72306 tRNA processing 0.151704 0.819
R-HSA-162587 HIV Life Cycle 0.124578 0.905
R-HSA-5619102 SLC transporter disorders 0.143733 0.842
R-HSA-9675108 Nervous system development 0.211416 0.675
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.212781 0.672
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.212781 0.672
R-HSA-3229121 Glycogen storage diseases 0.212781 0.672
R-HSA-2028269 Signaling by Hippo 0.212781 0.672
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.212781 0.672
R-HSA-9694516 SARS-CoV-2 Infection 0.214638 0.668
R-HSA-389948 Co-inhibition by PD-1 0.216216 0.665
R-HSA-9909396 Circadian clock 0.218342 0.661
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.220196 0.657
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.221169 0.655
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.221302 0.655
R-HSA-3928664 Ephrin signaling 0.221302 0.655
R-HSA-156711 Polo-like kinase mediated events 0.221302 0.655
R-HSA-8953854 Metabolism of RNA 0.222437 0.653
R-HSA-69473 G2/M DNA damage checkpoint 0.224174 0.649
R-HSA-1226099 Signaling by FGFR in disease 0.224174 0.649
R-HSA-380287 Centrosome maturation 0.228158 0.642
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.229731 0.639
R-HSA-9754189 Germ layer formation at gastrulation 0.229731 0.639
R-HSA-9834899 Specification of the neural plate border 0.229731 0.639
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.229731 0.639
R-HSA-912631 Regulation of signaling by CBL 0.229731 0.639
R-HSA-1980143 Signaling by NOTCH1 0.232147 0.634
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.238069 0.623
R-HSA-3322077 Glycogen synthesis 0.238069 0.623
R-HSA-9823730 Formation of definitive endoderm 0.238069 0.623
R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.238069 0.623
R-HSA-9629569 Protein hydroxylation 0.238069 0.623
R-HSA-1181150 Signaling by NODAL 0.238069 0.623
R-HSA-416482 G alpha (12/13) signalling events 0.240137 0.620
R-HSA-6807070 PTEN Regulation 0.241152 0.618
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.246318 0.609
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.246318 0.609
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.246318 0.609
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.248141 0.605
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.248141 0.605
R-HSA-9833482 PKR-mediated signaling 0.248141 0.605
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.252147 0.598
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.253783 0.596
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.254477 0.594
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.254477 0.594
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.254477 0.594
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.254477 0.594
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.254477 0.594
R-HSA-9671555 Signaling by PDGFR in disease 0.254477 0.594
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.256154 0.591
R-HSA-418990 Adherens junctions interactions 0.260383 0.584
R-HSA-166208 mTORC1-mediated signalling 0.262549 0.581
R-HSA-8964038 LDL clearance 0.262549 0.581
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.264171 0.578
R-HSA-5687128 MAPK6/MAPK4 signaling 0.268181 0.572
R-HSA-6794362 Protein-protein interactions at synapses 0.268181 0.572
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.270178 0.568
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.270534 0.568
R-HSA-982772 Growth hormone receptor signaling 0.270534 0.568
R-HSA-9758941 Gastrulation 0.273104 0.564
R-HSA-422475 Axon guidance 0.274887 0.561
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.276199 0.559
R-HSA-381038 XBP1(S) activates chaperone genes 0.276199 0.559
R-HSA-913531 Interferon Signaling 0.277161 0.557
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.278433 0.555
R-HSA-8863678 Neurodegenerative Diseases 0.278433 0.555
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.278433 0.555
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.278967 0.554
R-HSA-162906 HIV Infection 0.281902 0.550
R-HSA-446652 Interleukin-1 family signaling 0.281903 0.550
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.284212 0.546
R-HSA-9663891 Selective autophagy 0.284212 0.546
R-HSA-9932444 ATP-dependent chromatin remodelers 0.286247 0.543
R-HSA-9932451 SWI/SNF chromatin remodelers 0.286247 0.543
R-HSA-3214842 HDMs demethylate histones 0.286247 0.543
R-HSA-9830364 Formation of the nephric duct 0.286247 0.543
R-HSA-1266695 Interleukin-7 signaling 0.286247 0.543
R-HSA-1236974 ER-Phagosome pathway 0.288216 0.540
R-HSA-1989781 PPARA activates gene expression 0.290728 0.537
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.292217 0.534
R-HSA-202424 Downstream TCR signaling 0.292217 0.534
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.293977 0.532
R-HSA-8986944 Transcriptional Regulation by MECP2 0.296216 0.528
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.296623 0.528
R-HSA-381070 IRE1alpha activates chaperones 0.300211 0.523
R-HSA-445095 Interaction between L1 and Ankyrins 0.301623 0.521
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.301623 0.521
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.301623 0.521
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.301623 0.521
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.301623 0.521
R-HSA-2682334 EPH-Ephrin signaling 0.304203 0.517
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.309188 0.510
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.309188 0.510
R-HSA-109581 Apoptosis 0.311389 0.507
R-HSA-9006335 Signaling by Erythropoietin 0.316670 0.499
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.324072 0.489
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.324072 0.489
R-HSA-6807878 COPI-mediated anterograde transport 0.324094 0.489
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.324094 0.489
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.328056 0.484
R-HSA-5619115 Disorders of transmembrane transporters 0.330552 0.481
R-HSA-182971 EGFR downregulation 0.331395 0.480
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.331395 0.480
R-HSA-186763 Downstream signal transduction 0.331395 0.480
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.332012 0.479
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.332012 0.479
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.332012 0.479
R-HSA-3214847 HATs acetylate histones 0.335962 0.474
R-HSA-4791275 Signaling by WNT in cancer 0.338638 0.470
R-HSA-421270 Cell-cell junction organization 0.340361 0.468
R-HSA-354192 Integrin signaling 0.345804 0.461
R-HSA-9930044 Nuclear RNA decay 0.345804 0.461
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.345804 0.461
R-HSA-9733709 Cardiogenesis 0.345804 0.461
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.352892 0.452
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.352892 0.452
R-HSA-5619507 Activation of HOX genes during differentiation 0.359505 0.444
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.359505 0.444
R-HSA-9833110 RSV-host interactions 0.359505 0.444
R-HSA-5205647 Mitophagy 0.359904 0.444
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.359904 0.444
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.363400 0.440
R-HSA-187687 Signalling to ERKs 0.366841 0.436
R-HSA-111933 Calmodulin induced events 0.373702 0.427
R-HSA-111997 CaM pathway 0.373702 0.427
R-HSA-9682385 FLT3 signaling in disease 0.373702 0.427
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.373702 0.427
R-HSA-6804757 Regulation of TP53 Degradation 0.373702 0.427
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.375032 0.426
R-HSA-2672351 Stimuli-sensing channels 0.375032 0.426
R-HSA-1236975 Antigen processing-Cross presentation 0.375032 0.426
R-HSA-1280218 Adaptive Immune System 0.376251 0.425
R-HSA-201681 TCF dependent signaling in response to WNT 0.376339 0.424
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.378891 0.421
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.380490 0.420
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.380490 0.420
R-HSA-5689896 Ovarian tumor domain proteases 0.380490 0.420
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.382740 0.417
R-HSA-166166 MyD88-independent TLR4 cascade 0.382740 0.417
R-HSA-69275 G2/M Transition 0.385131 0.414
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.387204 0.412
R-HSA-453274 Mitotic G2-G2/M phases 0.390978 0.408
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.393847 0.405
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.393847 0.405
R-HSA-8964043 Plasma lipoprotein clearance 0.393847 0.405
R-HSA-201556 Signaling by ALK 0.393847 0.405
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.393847 0.405
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.394224 0.404
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.400417 0.397
R-HSA-9646399 Aggrephagy 0.400417 0.397
R-HSA-8982491 Glycogen metabolism 0.400417 0.397
R-HSA-1251985 Nuclear signaling by ERBB4 0.400417 0.397
R-HSA-202433 Generation of second messenger molecules 0.400417 0.397
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.405611 0.392
R-HSA-446728 Cell junction organization 0.406537 0.391
R-HSA-9607240 FLT3 Signaling 0.406917 0.390
R-HSA-9694548 Maturation of spike protein 0.406917 0.390
R-HSA-72163 mRNA Splicing - Major Pathway 0.408431 0.389
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.413347 0.384
R-HSA-5674135 MAP2K and MAPK activation 0.413347 0.384
R-HSA-9656223 Signaling by RAF1 mutants 0.413347 0.384
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.413347 0.384
R-HSA-9007101 Rab regulation of trafficking 0.416896 0.380
R-HSA-1592230 Mitochondrial biogenesis 0.416896 0.380
R-HSA-2980736 Peptide hormone metabolism 0.416896 0.380
R-HSA-111996 Ca-dependent events 0.419707 0.377
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.419707 0.377
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.419707 0.377
R-HSA-3928662 EPHB-mediated forward signaling 0.432223 0.364
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.432223 0.364
R-HSA-5673001 RAF/MAP kinase cascade 0.433214 0.363
R-HSA-3700989 Transcriptional Regulation by TP53 0.434073 0.362
R-HSA-9679506 SARS-CoV Infections 0.436081 0.360
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.438380 0.358
R-HSA-9824272 Somitogenesis 0.438380 0.358
R-HSA-1489509 DAG and IP3 signaling 0.438380 0.358
R-HSA-72172 mRNA Splicing 0.440023 0.357
R-HSA-5357801 Programmed Cell Death 0.442865 0.354
R-HSA-72165 mRNA Splicing - Minor Pathway 0.444470 0.352
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.444470 0.352
R-HSA-9649948 Signaling downstream of RAS mutants 0.444470 0.352
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.444470 0.352
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.444470 0.352
R-HSA-6802949 Signaling by RAS mutants 0.444470 0.352
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.447940 0.349
R-HSA-5684996 MAPK1/MAPK3 signaling 0.450026 0.347
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.450495 0.346
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.456455 0.341
R-HSA-389356 Co-stimulation by CD28 0.456455 0.341
R-HSA-69481 G2/M Checkpoints 0.457318 0.340
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.460913 0.336
R-HSA-9766229 Degradation of CDH1 0.462351 0.335
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.462596 0.335
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.468063 0.330
R-HSA-5658442 Regulation of RAS by GAPs 0.468183 0.330
R-HSA-109704 PI3K Cascade 0.468183 0.330
R-HSA-9748787 Azathioprine ADME 0.468183 0.330
R-HSA-3371571 HSF1-dependent transactivation 0.473952 0.324
R-HSA-5576891 Cardiac conduction 0.475156 0.323
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.479659 0.319
R-HSA-6794361 Neurexins and neuroligins 0.479659 0.319
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.479659 0.319
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.485304 0.314
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.485304 0.314
R-HSA-9639288 Amino acids regulate mTORC1 0.485304 0.314
R-HSA-445355 Smooth Muscle Contraction 0.485304 0.314
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.490888 0.309
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.496413 0.304
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.496413 0.304
R-HSA-3214815 HDACs deacetylate histones 0.496413 0.304
R-HSA-9753281 Paracetamol ADME 0.496413 0.304
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.499528 0.301
R-HSA-8878171 Transcriptional regulation by RUNX1 0.501119 0.300
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.501877 0.299
R-HSA-177929 Signaling by EGFR 0.501877 0.299
R-HSA-5578775 Ion homeostasis 0.501877 0.299
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.501877 0.299
R-HSA-1852241 Organelle biogenesis and maintenance 0.506345 0.296
R-HSA-381119 Unfolded Protein Response (UPR) 0.506358 0.296
R-HSA-9764561 Regulation of CDH1 Function 0.507283 0.295
R-HSA-112399 IRS-mediated signalling 0.507283 0.295
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.512630 0.290
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.517920 0.286
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.523152 0.281
R-HSA-2871837 FCERI mediated NF-kB activation 0.526484 0.279
R-HSA-2428928 IRS-related events triggered by IGF1R 0.528328 0.277
R-HSA-9793380 Formation of paraxial mesoderm 0.528328 0.277
R-HSA-112043 PLC beta mediated events 0.528328 0.277
R-HSA-1280215 Cytokine Signaling in Immune system 0.530583 0.275
R-HSA-1643685 Disease 0.532227 0.274
R-HSA-9707616 Heme signaling 0.533448 0.273
R-HSA-375165 NCAM signaling for neurite out-growth 0.533448 0.273
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.533448 0.273
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.533448 0.273
R-HSA-186797 Signaling by PDGF 0.533448 0.273
R-HSA-199977 ER to Golgi Anterograde Transport 0.536339 0.271
R-HSA-166520 Signaling by NTRKs 0.539593 0.268
R-HSA-69242 S Phase 0.539593 0.268
R-HSA-74751 Insulin receptor signalling cascade 0.543523 0.265
R-HSA-2428924 IGF1R signaling cascade 0.543523 0.265
R-HSA-9856651 MITF-M-dependent gene expression 0.546054 0.263
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.548479 0.261
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.548479 0.261
R-HSA-449147 Signaling by Interleukins 0.556440 0.255
R-HSA-5693606 DNA Double Strand Break Response 0.558232 0.253
R-HSA-112040 G-protein mediated events 0.558232 0.253
R-HSA-9830369 Kidney development 0.558232 0.253
R-HSA-168256 Immune System 0.559202 0.252
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.563029 0.249
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.571262 0.243
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.572469 0.242
R-HSA-69202 Cyclin E associated events during G1/S transition 0.572469 0.242
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.577112 0.239
R-HSA-453276 Regulation of mitotic cell cycle 0.577112 0.239
R-HSA-5632684 Hedgehog 'on' state 0.577112 0.239
R-HSA-9006936 Signaling by TGFB family members 0.577405 0.239
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.581706 0.235
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.581706 0.235
R-HSA-4086398 Ca2+ pathway 0.586249 0.232
R-HSA-69052 Switching of origins to a post-replicative state 0.586249 0.232
R-HSA-5663084 Diseases of carbohydrate metabolism 0.586249 0.232
R-HSA-1236394 Signaling by ERBB4 0.590744 0.229
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.592292 0.227
R-HSA-9824446 Viral Infection Pathways 0.597613 0.224
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.603939 0.219
R-HSA-9694635 Translation of Structural Proteins 0.603939 0.219
R-HSA-383280 Nuclear Receptor transcription pathway 0.608243 0.216
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.608243 0.216
R-HSA-216083 Integrin cell surface interactions 0.608243 0.216
R-HSA-5621481 C-type lectin receptors (CLRs) 0.612913 0.213
R-HSA-112316 Neuronal System 0.616132 0.210
R-HSA-5693607 Processing of DNA double-strand break ends 0.620877 0.207
R-HSA-977225 Amyloid fiber formation 0.620877 0.207
R-HSA-76002 Platelet activation, signaling and aggregation 0.621367 0.207
R-HSA-9707564 Cytoprotection by HMOX1 0.629073 0.201
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.633105 0.199
R-HSA-6802957 Oncogenic MAPK signaling 0.637094 0.196
R-HSA-9824443 Parasitic Infection Pathways 0.637179 0.196
R-HSA-9658195 Leishmania infection 0.637179 0.196
R-HSA-2559583 Cellular Senescence 0.638028 0.195
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.639400 0.194
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.644942 0.190
R-HSA-109582 Hemostasis 0.651379 0.186
R-HSA-9645723 Diseases of programmed cell death 0.652621 0.185
R-HSA-5617833 Cilium Assembly 0.664423 0.178
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.669513 0.174
R-HSA-74752 Signaling by Insulin receptor 0.671104 0.173
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.671104 0.173
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.671104 0.173
R-HSA-195721 Signaling by WNT 0.673651 0.172
R-HSA-68867 Assembly of the pre-replicative complex 0.674682 0.171
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.678221 0.169
R-HSA-157579 Telomere Maintenance 0.691998 0.160
R-HSA-948021 Transport to the Golgi and subsequent modification 0.694040 0.159
R-HSA-8957275 Post-translational protein phosphorylation 0.695349 0.158
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.696408 0.157
R-HSA-376176 Signaling by ROBO receptors 0.696408 0.157
R-HSA-5610787 Hedgehog 'off' state 0.701944 0.154
R-HSA-382556 ABC-family proteins mediated transport 0.701944 0.154
R-HSA-9009391 Extra-nuclear estrogen signaling 0.705188 0.152
R-HSA-9842860 Regulation of endogenous retroelements 0.708397 0.150
R-HSA-111885 Opioid Signalling 0.714711 0.146
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.714711 0.146
R-HSA-112315 Transmission across Chemical Synapses 0.722307 0.141
R-HSA-9692914 SARS-CoV-1-host interactions 0.723927 0.140
R-HSA-69239 Synthesis of DNA 0.726933 0.139
R-HSA-69002 DNA Replication Pre-Initiation 0.732848 0.135
R-HSA-6803157 Antimicrobial peptides 0.738635 0.132
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.747083 0.127
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.749839 0.125
R-HSA-373760 L1CAM interactions 0.757926 0.120
R-HSA-5693538 Homology Directed Repair 0.763173 0.117
R-HSA-73886 Chromosome Maintenance 0.770833 0.113
R-HSA-157118 Signaling by NOTCH 0.775721 0.110
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.775801 0.110
R-HSA-2132295 MHC class II antigen presentation 0.775801 0.110
R-HSA-6809371 Formation of the cornified envelope 0.778245 0.109
R-HSA-69206 G1/S Transition 0.783054 0.106
R-HSA-8856688 Golgi-to-ER retrograde transport 0.801275 0.096
R-HSA-5688426 Deubiquitination 0.801709 0.096
R-HSA-3858494 Beta-catenin independent WNT signaling 0.811881 0.091
R-HSA-5358351 Signaling by Hedgehog 0.815965 0.088
R-HSA-416476 G alpha (q) signalling events 0.815995 0.088
R-HSA-9664407 Parasite infection 0.819960 0.086
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.819960 0.086
R-HSA-9664417 Leishmania phagocytosis 0.819960 0.086
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.821925 0.085
R-HSA-8856828 Clathrin-mediated endocytosis 0.827693 0.082
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.833276 0.079
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.840440 0.075
R-HSA-5663205 Infectious disease 0.843461 0.074
R-HSA-5693532 DNA Double-Strand Break Repair 0.845612 0.073
R-HSA-69306 DNA Replication 0.845612 0.073
R-HSA-9711097 Cellular response to starvation 0.853864 0.069
R-HSA-199991 Membrane Trafficking 0.855853 0.068
R-HSA-5633007 Regulation of TP53 Activity 0.857040 0.067
R-HSA-382551 Transport of small molecules 0.857824 0.067
R-HSA-168249 Innate Immune System 0.875548 0.058
R-HSA-5689880 Ub-specific processing proteases 0.877434 0.057
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.878775 0.056
R-HSA-9678108 SARS-CoV-1 Infection 0.880101 0.055
R-HSA-5653656 Vesicle-mediated transport 0.891186 0.050
R-HSA-6798695 Neutrophil degranulation 0.894384 0.048
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.908948 0.041
R-HSA-6805567 Keratinization 0.915707 0.038
R-HSA-9006931 Signaling by Nuclear Receptors 0.922054 0.035
R-HSA-9748784 Drug ADME 0.926154 0.033
R-HSA-8951664 Neddylation 0.928558 0.032
R-HSA-597592 Post-translational protein modification 0.928591 0.032
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.934595 0.029
R-HSA-8939211 ESR-mediated signaling 0.940124 0.027
R-HSA-202733 Cell surface interactions at the vascular wall 0.940124 0.027
R-HSA-446203 Asparagine N-linked glycosylation 0.954874 0.020
R-HSA-1474244 Extracellular matrix organization 0.978862 0.009
R-HSA-73894 DNA Repair 0.984689 0.007
R-HSA-9824439 Bacterial Infection Pathways 0.989160 0.005
R-HSA-418594 G alpha (i) signalling events 0.991033 0.004
R-HSA-388396 GPCR downstream signalling 0.992741 0.003
R-HSA-5668914 Diseases of metabolism 0.992829 0.003
R-HSA-392499 Metabolism of proteins 0.996370 0.002
R-HSA-372790 Signaling by GPCR 0.996617 0.001
R-HSA-9709957 Sensory Perception 0.999918 0.000
R-HSA-556833 Metabolism of lipids 0.999994 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GSK3AGSK3A 0.795 0.536 4 0.659
GSK3BGSK3B 0.783 0.508 4 0.661
CLK3CLK3 0.775 0.249 1 0.802
CLK2CLK2 0.765 0.230 -3 0.688
KISKIS 0.762 0.150 1 0.740
COTCOT 0.759 0.175 2 0.822
GRK1GRK1 0.759 0.264 -2 0.819
NDR2NDR2 0.752 0.110 -3 0.815
PIM3PIM3 0.752 0.126 -3 0.795
MTORMTOR 0.752 0.147 1 0.707
MOSMOS 0.750 0.154 1 0.786
HIPK4HIPK4 0.750 0.100 1 0.832
DYRK2DYRK2 0.749 0.147 1 0.798
SRPK1SRPK1 0.749 0.091 -3 0.703
CDC7CDC7 0.748 0.084 1 0.736
SKMLCKSKMLCK 0.746 0.141 -2 0.874
GRK7GRK7 0.746 0.245 1 0.692
HIPK2HIPK2 0.744 0.131 1 0.734
DYRK4DYRK4 0.743 0.160 1 0.729
RSK2RSK2 0.742 0.104 -3 0.714
CDK1CDK1 0.741 0.124 1 0.721
PIM1PIM1 0.740 0.107 -3 0.726
GRK5GRK5 0.739 0.188 -3 0.783
ATRATR 0.739 0.076 1 0.761
NLKNLK 0.739 0.069 1 0.810
IKKBIKKB 0.739 0.107 -2 0.722
CLK4CLK4 0.739 0.122 -3 0.687
CDK18CDK18 0.737 0.099 1 0.704
ERK5ERK5 0.737 0.073 1 0.797
CAMK2ACAMK2A 0.737 0.168 2 0.747
PRPKPRPK 0.736 -0.008 -1 0.789
CHAK2CHAK2 0.735 0.068 -1 0.792
CAMK2GCAMK2G 0.735 0.108 2 0.741
CDK8CDK8 0.734 0.087 1 0.725
PRKD1PRKD1 0.734 0.039 -3 0.789
P90RSKP90RSK 0.734 0.070 -3 0.718
CDK19CDK19 0.734 0.089 1 0.700
GRK6GRK6 0.734 0.203 1 0.728
JNK3JNK3 0.734 0.136 1 0.714
HIPK1HIPK1 0.734 0.108 1 0.809
CDKL1CDKL1 0.733 0.026 -3 0.740
CAMK2BCAMK2B 0.733 0.154 2 0.721
IKKAIKKA 0.733 0.091 -2 0.718
ICKICK 0.733 0.070 -3 0.784
CK1ECK1E 0.733 0.108 -3 0.549
JNK2JNK2 0.732 0.126 1 0.682
CAMK1BCAMK1B 0.732 0.023 -3 0.765
CDKL5CDKL5 0.732 0.024 -3 0.735
NDR1NDR1 0.732 0.014 -3 0.774
PDHK4PDHK4 0.731 -0.009 1 0.736
LATS1LATS1 0.731 0.162 -3 0.835
PRKXPRKX 0.731 0.110 -3 0.637
BMPR1BBMPR1B 0.731 0.107 1 0.707
AURCAURC 0.730 0.054 -2 0.665
SRPK2SRPK2 0.730 0.043 -3 0.627
PASKPASK 0.729 0.219 -3 0.825
PKACGPKACG 0.729 0.058 -2 0.739
CLK1CLK1 0.729 0.092 -3 0.659
FAM20CFAM20C 0.729 0.081 2 0.554
RAF1RAF1 0.729 -0.033 1 0.695
CDK7CDK7 0.729 0.064 1 0.736
CDK13CDK13 0.729 0.090 1 0.717
RSK4RSK4 0.729 0.092 -3 0.708
NUAK2NUAK2 0.729 0.007 -3 0.765
CK1DCK1D 0.729 0.137 -3 0.508
CDK5CDK5 0.728 0.077 1 0.759
LATS2LATS2 0.728 0.033 -5 0.731
RIPK3RIPK3 0.728 0.025 3 0.742
GRK4GRK4 0.728 0.119 -2 0.842
SRPK3SRPK3 0.728 0.046 -3 0.671
MARK4MARK4 0.728 -0.026 4 0.173
CAMK2DCAMK2D 0.728 0.080 -3 0.769
P38GP38G 0.727 0.097 1 0.648
PRKD2PRKD2 0.727 0.025 -3 0.724
DSTYKDSTYK 0.727 -0.020 2 0.828
P38BP38B 0.727 0.109 1 0.711
PKACBPKACB 0.726 0.070 -2 0.678
CDK17CDK17 0.726 0.086 1 0.659
MSK1MSK1 0.726 0.096 -3 0.691
BMPR2BMPR2 0.725 -0.068 -2 0.869
WNK1WNK1 0.725 -0.012 -2 0.875
CK1ACK1A 0.725 0.199 -3 0.428
ERK1ERK1 0.725 0.097 1 0.697
GCN2GCN2 0.725 -0.099 2 0.737
DAPK2DAPK2 0.725 0.017 -3 0.784
MST4MST4 0.725 -0.005 2 0.800
HUNKHUNK 0.725 -0.037 2 0.795
CK1A2CK1A2 0.725 0.132 -3 0.504
P38DP38D 0.725 0.120 1 0.666
CK1G1CK1G1 0.725 0.119 -3 0.537
MAPKAPK2MAPKAPK2 0.724 0.047 -3 0.689
DYRK3DYRK3 0.724 0.096 1 0.814
RSK3RSK3 0.724 0.009 -3 0.701
CAMLCKCAMLCK 0.723 0.014 -2 0.840
NEK6NEK6 0.723 -0.036 -2 0.847
CDK3CDK3 0.723 0.088 1 0.679
DYRK1BDYRK1B 0.723 0.095 1 0.747
TBK1TBK1 0.723 -0.068 1 0.577
CDK12CDK12 0.723 0.083 1 0.690
CDK10CDK10 0.722 0.092 1 0.726
MLK1MLK1 0.722 0.010 2 0.755
P38AP38A 0.722 0.075 1 0.758
NIKNIK 0.722 -0.032 -3 0.787
MASTLMASTL 0.722 -0.009 -2 0.799
DLKDLK 0.722 0.071 1 0.706
JNK1JNK1 0.721 0.132 1 0.690
PKN2PKN2 0.721 -0.020 -3 0.752
AMPKA1AMPKA1 0.721 -0.034 -3 0.782
IKKEIKKE 0.721 -0.046 1 0.570
CDK9CDK9 0.721 0.071 1 0.719
P70S6KBP70S6KB 0.721 0.015 -3 0.714
PKN3PKN3 0.720 -0.034 -3 0.763
CDK14CDK14 0.720 0.080 1 0.733
TGFBR1TGFBR1 0.720 0.072 -2 0.824
TGFBR2TGFBR2 0.719 -0.056 -2 0.808
MSK2MSK2 0.719 0.034 -3 0.698
DYRK1ADYRK1A 0.719 0.064 1 0.762
ATMATM 0.718 0.030 1 0.698
NEK7NEK7 0.718 -0.062 -3 0.766
PAK1PAK1 0.718 0.026 -2 0.782
ALK4ALK4 0.717 0.044 -2 0.846
CDK16CDK16 0.717 0.073 1 0.678
PKCBPKCB 0.717 -0.002 2 0.675
GRK2GRK2 0.717 0.080 -2 0.730
MPSK1MPSK1 0.717 0.111 1 0.797
ULK2ULK2 0.717 -0.134 2 0.717
AMPKA2AMPKA2 0.717 -0.022 -3 0.753
ERK2ERK2 0.717 0.076 1 0.727
IRE1IRE1 0.716 -0.049 1 0.739
SMG1SMG1 0.716 0.017 1 0.726
PDHK1PDHK1 0.716 -0.145 1 0.707
MNK1MNK1 0.716 0.021 -2 0.789
MLK3MLK3 0.716 -0.003 2 0.692
GRK3GRK3 0.716 0.124 -2 0.702
TLK2TLK2 0.716 0.069 1 0.694
PKCDPKCD 0.716 -0.025 2 0.718
MAPKAPK3MAPKAPK3 0.716 -0.018 -3 0.720
MAKMAK 0.715 0.114 -2 0.742
QSKQSK 0.715 -0.036 4 0.146
RIPK1RIPK1 0.715 -0.024 1 0.723
CK2A1CK2A1 0.715 0.194 1 0.629
TSSK1TSSK1 0.715 -0.037 -3 0.809
DNAPKDNAPK 0.714 0.069 1 0.610
PRP4PRP4 0.714 0.072 -3 0.742
HIPK3HIPK3 0.714 0.054 1 0.762
MLK2MLK2 0.713 -0.057 2 0.763
MNK2MNK2 0.713 -0.012 -2 0.781
TSSK2TSSK2 0.713 -0.036 -5 0.787
PKCGPKCG 0.713 -0.029 2 0.690
MARK3MARK3 0.713 -0.036 4 0.146
PKCZPKCZ 0.713 -0.013 2 0.712
BCKDKBCKDK 0.712 -0.113 -1 0.729
VRK2VRK2 0.712 0.045 1 0.797
ACVR2BACVR2B 0.712 0.052 -2 0.806
NIM1NIM1 0.712 -0.035 3 0.763
ANKRD3ANKRD3 0.712 -0.047 1 0.739
GAKGAK 0.712 0.208 1 0.830
CK2A2CK2A2 0.711 0.141 1 0.648
PKCAPKCA 0.711 -0.020 2 0.665
AKT2AKT2 0.711 0.020 -3 0.626
ALK2ALK2 0.711 0.061 -2 0.830
MYLK4MYLK4 0.711 0.014 -2 0.774
TTBK2TTBK2 0.710 -0.045 2 0.664
PKRPKR 0.710 0.002 1 0.764
CDK2CDK2 0.710 0.018 1 0.776
ULK1ULK1 0.710 -0.096 -3 0.721
AURBAURB 0.710 0.016 -2 0.659
BMPR1ABMPR1A 0.710 0.072 1 0.675
PLK1PLK1 0.709 0.053 -2 0.776
DRAK1DRAK1 0.709 0.039 1 0.667
ACVR2AACVR2A 0.709 0.037 -2 0.792
PKG2PKG2 0.708 0.011 -2 0.674
NEK9NEK9 0.708 -0.096 2 0.757
MEK1MEK1 0.708 -0.026 2 0.816
AURAAURA 0.708 0.033 -2 0.636
PIM2PIM2 0.708 0.018 -3 0.671
CAMK1GCAMK1G 0.708 0.003 -3 0.680
PAK3PAK3 0.708 -0.031 -2 0.773
DCAMKL1DCAMKL1 0.707 0.018 -3 0.723
CHAK1CHAK1 0.707 -0.055 2 0.730
MEKK3MEKK3 0.706 0.085 1 0.675
CAMK4CAMK4 0.706 -0.057 -3 0.735
MARK2MARK2 0.706 -0.072 4 0.131
MST3MST3 0.706 0.033 2 0.802
WNK3WNK3 0.706 -0.178 1 0.690
QIKQIK 0.705 -0.090 -3 0.750
MLK4MLK4 0.705 -0.029 2 0.673
PAK2PAK2 0.705 -0.006 -2 0.763
SIKSIK 0.705 -0.047 -3 0.687
MOKMOK 0.704 0.070 1 0.845
PKCHPKCH 0.704 -0.036 2 0.656
YSK4YSK4 0.704 -0.032 1 0.628
PKACAPKACA 0.703 0.037 -2 0.631
SGK3SGK3 0.703 -0.006 -3 0.698
PRKD3PRKD3 0.703 -0.046 -3 0.671
PLK3PLK3 0.702 0.031 2 0.736
BRSK1BRSK1 0.701 -0.056 -3 0.720
PHKG1PHKG1 0.700 -0.091 -3 0.762
DAPK1DAPK1 0.700 0.070 -3 0.714
IRE2IRE2 0.700 -0.088 2 0.660
NUAK1NUAK1 0.699 -0.087 -3 0.707
TAO3TAO3 0.698 0.016 1 0.668
PINK1PINK1 0.698 -0.065 1 0.827
BRSK2BRSK2 0.698 -0.095 -3 0.733
MEK5MEK5 0.697 -0.066 2 0.775
MELKMELK 0.697 -0.085 -3 0.725
DAPK3DAPK3 0.697 0.025 -3 0.732
NEK5NEK5 0.697 -0.045 1 0.728
TLK1TLK1 0.697 -0.045 -2 0.845
MARK1MARK1 0.697 -0.083 4 0.144
NEK2NEK2 0.696 -0.101 2 0.743
MAPKAPK5MAPKAPK5 0.696 -0.039 -3 0.654
SSTKSSTK 0.695 -0.058 4 0.136
PKCEPKCE 0.695 -0.009 2 0.671
PLK4PLK4 0.695 -0.070 2 0.613
PAK6PAK6 0.694 -0.029 -2 0.688
BUB1BUB1 0.694 0.077 -5 0.772
SMMLCKSMMLCK 0.694 -0.013 -3 0.730
LKB1LKB1 0.694 -0.025 -3 0.777
MEKK2MEKK2 0.694 -0.039 2 0.740
CDK6CDK6 0.692 0.038 1 0.711
PERKPERK 0.692 -0.099 -2 0.827
GCKGCK 0.692 0.033 1 0.660
NEK11NEK11 0.692 -0.037 1 0.650
WNK4WNK4 0.692 -0.087 -2 0.867
ZAKZAK 0.691 -0.085 1 0.643
PLK2PLK2 0.691 0.067 -3 0.654
ERK7ERK7 0.691 -0.001 2 0.493
CHK1CHK1 0.691 -0.068 -3 0.756
AKT1AKT1 0.690 -0.009 -3 0.648
SGK1SGK1 0.690 0.032 -3 0.561
DCAMKL2DCAMKL2 0.690 -0.040 -3 0.722
P70S6KP70S6K 0.689 -0.013 -3 0.630
PKCIPKCI 0.689 -0.045 2 0.685
MEKK1MEKK1 0.689 -0.114 1 0.684
CAMK1DCAMK1D 0.688 -0.013 -3 0.615
CDK4CDK4 0.687 0.033 1 0.690
IRAK4IRAK4 0.687 -0.117 1 0.715
PBKPBK 0.687 0.048 1 0.771
SNRKSNRK 0.687 -0.152 2 0.632
PKCTPKCT 0.686 -0.078 2 0.660
CK1G3CK1G3 0.686 0.161 -3 0.387
BRAFBRAF 0.685 -0.122 -4 0.532
CAMKK2CAMKK2 0.685 -0.028 -2 0.718
PDK1PDK1 0.685 -0.035 1 0.665
ROCK2ROCK2 0.684 0.013 -3 0.719
HRIHRI 0.684 -0.163 -2 0.836
HPK1HPK1 0.684 0.001 1 0.642
STK33STK33 0.684 -0.018 2 0.613
EEF2KEEF2K 0.684 -0.009 3 0.793
MRCKAMRCKA 0.684 0.013 -3 0.674
AKT3AKT3 0.683 -0.005 -3 0.587
PAK4PAK4 0.683 -0.005 -2 0.647
YANK3YANK3 0.682 0.017 2 0.428
CAMKK1CAMKK1 0.682 -0.085 -2 0.720
VRK1VRK1 0.682 -0.038 2 0.779
MST2MST2 0.682 -0.040 1 0.663
NEK8NEK8 0.681 -0.105 2 0.745
PAK5PAK5 0.681 -0.033 -2 0.641
CK1G2CK1G2 0.681 0.157 -3 0.467
LRRK2LRRK2 0.680 -0.059 2 0.776
TTBK1TTBK1 0.679 -0.085 2 0.593
MEKK6MEKK6 0.679 -0.127 1 0.669
MAP3K15MAP3K15 0.679 -0.082 1 0.626
PDHK4_TYRPDHK4_TYR 0.678 0.277 2 0.836
TNIKTNIK 0.678 -0.054 3 0.841
MRCKBMRCKB 0.678 -0.019 -3 0.657
PDHK3_TYRPDHK3_TYR 0.678 0.271 4 0.260
TAO2TAO2 0.677 -0.113 2 0.769
KHS2KHS2 0.677 -0.006 1 0.649
DMPK1DMPK1 0.677 0.017 -3 0.681
MINKMINK 0.676 -0.067 1 0.641
TAK1TAK1 0.675 -0.022 1 0.669
HGKHGK 0.675 -0.072 3 0.837
SLKSLK 0.675 -0.036 -2 0.694
CHK2CHK2 0.674 -0.037 -3 0.567
PHKG2PHKG2 0.674 -0.135 -3 0.698
KHS1KHS1 0.674 -0.045 1 0.633
SBKSBK 0.674 0.004 -3 0.519
HASPINHASPIN 0.673 -0.003 -1 0.670
NEK4NEK4 0.673 -0.138 1 0.662
NEK1NEK1 0.672 -0.095 1 0.689
MAP2K6_TYRMAP2K6_TYR 0.672 0.213 -1 0.809
CRIKCRIK 0.671 0.017 -3 0.662
MST1MST1 0.670 -0.079 1 0.646
CAMK1ACAMK1A 0.670 -0.042 -3 0.589
LOKLOK 0.669 -0.097 -2 0.738
IRAK1IRAK1 0.668 -0.192 -1 0.668
OSR1OSR1 0.668 -0.035 2 0.764
MAP2K4_TYRMAP2K4_TYR 0.667 0.149 -1 0.805
ROCK1ROCK1 0.667 -0.014 -3 0.670
PKN1PKN1 0.666 -0.082 -3 0.645
BIKEBIKE 0.666 0.045 1 0.780
BMPR2_TYRBMPR2_TYR 0.666 0.110 -1 0.788
PDHK1_TYRPDHK1_TYR 0.665 0.121 -1 0.804
TTKTTK 0.665 -0.037 -2 0.815
YSK1YSK1 0.663 -0.105 2 0.732
TESK1_TYRTESK1_TYR 0.663 -0.014 3 0.858
PKMYT1_TYRPKMYT1_TYR 0.662 0.007 3 0.833
ALPHAK3ALPHAK3 0.662 0.036 -1 0.682
MEK2MEK2 0.661 -0.176 2 0.764
PKG1PKG1 0.659 -0.053 -2 0.595
MAP2K7_TYRMAP2K7_TYR 0.659 -0.003 2 0.801
MYO3BMYO3B 0.658 -0.073 2 0.754
AAK1AAK1 0.657 0.073 1 0.714
LIMK2_TYRLIMK2_TYR 0.656 -0.039 -3 0.812
YANK2YANK2 0.655 0.019 2 0.433
RIPK2RIPK2 0.655 -0.167 1 0.582
PINK1_TYRPINK1_TYR 0.653 -0.074 1 0.750
MYO3AMYO3A 0.650 -0.092 1 0.672
ASK1ASK1 0.650 -0.112 1 0.616
NEK3NEK3 0.648 -0.206 1 0.624
FGRFGR 0.647 -0.049 1 0.768
LIMK1_TYRLIMK1_TYR 0.647 -0.122 2 0.774
DDR1DDR1 0.646 -0.082 4 0.215
EPHB4EPHB4 0.644 -0.047 -1 0.710
YES1YES1 0.644 -0.034 -1 0.751
TXKTXK 0.644 0.001 1 0.730
EPHA6EPHA6 0.644 -0.092 -1 0.742
TAO1TAO1 0.643 -0.131 1 0.578
ABL2ABL2 0.643 -0.057 -1 0.706
RETRET 0.643 -0.140 1 0.688
TNK2TNK2 0.642 -0.034 3 0.727
EPHA4EPHA4 0.641 -0.006 2 0.760
BLKBLK 0.641 -0.007 -1 0.729
FYNFYN 0.640 0.031 -1 0.705
LCKLCK 0.640 -0.046 -1 0.723
MST1RMST1R 0.639 -0.189 3 0.796
ABL1ABL1 0.639 -0.070 -1 0.699
CSF1RCSF1R 0.638 -0.117 3 0.775
DDR2DDR2 0.638 0.030 3 0.706
METMET 0.637 -0.059 3 0.768
FERFER 0.637 -0.110 1 0.753
SRMSSRMS 0.637 -0.033 1 0.726
TYRO3TYRO3 0.636 -0.181 3 0.781
TYK2TYK2 0.636 -0.200 1 0.675
STLK3STLK3 0.636 -0.136 1 0.603
PTK2PTK2 0.636 0.049 -1 0.682
HCKHCK 0.636 -0.087 -1 0.718
INSRRINSRR 0.635 -0.062 3 0.732
KITKIT 0.635 -0.075 3 0.774
ITKITK 0.635 -0.065 -1 0.686
JAK2JAK2 0.635 -0.156 1 0.663
ROS1ROS1 0.635 -0.192 3 0.760
FLT1FLT1 0.635 0.012 -1 0.715
SYKSYK 0.634 0.088 -1 0.661
KDRKDR 0.634 -0.089 3 0.738
EPHB1EPHB1 0.634 -0.049 1 0.705
JAK3JAK3 0.634 -0.128 1 0.663
BMXBMX 0.631 -0.034 -1 0.609
EPHB3EPHB3 0.631 -0.075 -1 0.688
FGFR2FGFR2 0.631 -0.126 3 0.775
WEE1_TYRWEE1_TYR 0.631 -0.061 -1 0.651
TNK1TNK1 0.630 -0.130 3 0.774
EPHB2EPHB2 0.629 -0.072 -1 0.681
TNNI3K_TYRTNNI3K_TYR 0.628 -0.133 1 0.702
SRCSRC 0.628 -0.021 -1 0.701
EPHA3EPHA3 0.626 -0.069 2 0.722
FGFR3FGFR3 0.626 -0.073 3 0.746
MERTKMERTK 0.626 -0.100 3 0.762
ERBB2ERBB2 0.625 -0.089 1 0.655
PTK2BPTK2B 0.624 -0.052 -1 0.665
PDGFRBPDGFRB 0.624 -0.191 3 0.782
LYNLYN 0.624 -0.077 3 0.704
NEK10_TYRNEK10_TYR 0.623 -0.126 1 0.551
TECTEC 0.623 -0.100 -1 0.619
EPHA7EPHA7 0.623 -0.072 2 0.746
FLT3FLT3 0.622 -0.196 3 0.769
JAK1JAK1 0.622 -0.123 1 0.598
EPHA5EPHA5 0.622 -0.025 2 0.739
AXLAXL 0.622 -0.149 3 0.762
TEKTEK 0.622 -0.192 3 0.718
NTRK1NTRK1 0.621 -0.115 -1 0.707
FGFR1FGFR1 0.620 -0.179 3 0.741
BTKBTK 0.620 -0.167 -1 0.654
MATKMATK 0.619 -0.086 -1 0.640
FRKFRK 0.619 -0.119 -1 0.724
PTK6PTK6 0.619 -0.144 -1 0.620
EGFREGFR 0.619 -0.036 1 0.579
EPHA8EPHA8 0.618 -0.052 -1 0.673
ERBB4ERBB4 0.617 -0.007 1 0.616
FLT4FLT4 0.617 -0.122 3 0.738
PDGFRAPDGFRA 0.617 -0.223 3 0.782
FGFR4FGFR4 0.616 -0.033 -1 0.650
ZAP70ZAP70 0.616 0.038 -1 0.605
INSRINSR 0.615 -0.144 3 0.718
NTRK3NTRK3 0.615 -0.101 -1 0.663
LTKLTK 0.614 -0.147 3 0.717
ALKALK 0.614 -0.183 3 0.690
CSKCSK 0.613 -0.080 2 0.743
EPHA2EPHA2 0.613 -0.029 -1 0.634
EPHA1EPHA1 0.612 -0.178 3 0.752
NTRK2NTRK2 0.609 -0.184 3 0.728
IGF1RIGF1R 0.605 -0.102 3 0.659
MUSKMUSK 0.597 -0.138 1 0.586
FESFES 0.591 -0.113 -1 0.585