Motif 520 (n=179)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S614 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NNZ2 | TUBB8B | S275 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| A8CG34 | POM121C | S355 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| A8CG34 | POM121C | S366 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O14777 | NDC80 | S62 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15040 | TECPR2 | S408 | ochoa | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) | Probably plays a role as positive regulator of autophagy. {ECO:0000269|PubMed:23176824}. |
| O15042 | U2SURP | S23 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15117 | FYB1 | S205 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15439 | ABCC4 | S661 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43166 | SIPA1L1 | S94 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43303 | CCP110 | S380 | ochoa | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O43524 | FOXO3 | S311 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60238 | BNIP3L | S164 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O75376 | NCOR1 | S2140 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94806 | PRKD3 | S27 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94887 | FARP2 | S336 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95359 | TACC2 | S1944 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95817 | BAG3 | S177 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95999 | BCL10 | S134 | ochoa|psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| P01275 | GCG | S32 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P02671 | FGA | S546 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04350 | TUBB4A | S275 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07332 | FES | S408 | ochoa | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| P07437 | TUBB | S275 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07949 | RET | S686 | ochoa | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P08648 | ITGA5 | S124 | ochoa | Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| P08651 | NFIC | S273 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P09769 | FGR | S54 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P15407 | FOSL1 | S251 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15923 | TCF3 | S154 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P17812 | CTPS1 | S571 | ochoa|psp | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P21453 | S1PR1 | S351 | ochoa|psp | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269|PubMed:10982820, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:11604399, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:22344443, ECO:0000269|PubMed:8626678, ECO:0000269|PubMed:9488656}. |
| P25054 | APC | S1340 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P29350 | PTPN6 | S553 | psp | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P29374 | ARID4A | S673 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P38398 | BRCA1 | S1457 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42858 | HTT | S415 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46821 | MAP1B | S1640 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47736 | RAP1GAP | S495 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P50616 | TOB1 | S148 | ochoa | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P52735 | VAV2 | S659 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P52943 | CRIP2 | S111 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P54727 | RAD23B | S168 | ochoa | UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. |
| P61073 | CXCR4 | S321 | ochoa | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}. |
| P68371 | TUBB4B | S275 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78310 | CXADR | S286 | ochoa | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
| P78310 | CXADR | S293 | ochoa|psp | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
| P82094 | TMF1 | S316 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P98082 | DAB2 | S324 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01167 | FOXK2 | S381 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02446 | SP4 | S122 | ochoa | Transcription factor Sp4 (SPR-1) | Binds to GT and GC boxes promoters elements. Probable transcriptional activator. |
| Q03431 | PTH1R | S489 | ochoa|psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q05209 | PTPN12 | S551 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08AD1 | CAMSAP2 | S1287 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12888 | TP53BP1 | S1631 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1642 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13131 | PRKAA1 | S494 | ochoa|psp | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13330 | MTA1 | S558 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13428 | TCOF1 | S475 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13480 | GAB1 | S253 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13546 | RIPK1 | S331 | ochoa | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13555 | CAMK2G | S419 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13796 | SHROOM2 | S919 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13885 | TUBB2A | S275 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14126 | DSG2 | S883 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14980 | NUMA1 | S158 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S1942 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15149 | PLEC | S4382 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15172 | PPP2R5A | S38 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15642 | TRIP10 | S500 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q16537 | PPP2R5E | S30 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q2KHR3 | QSER1 | S495 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2M1P5 | KIF7 | S452 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q32P44 | EML3 | S156 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q3V6T2 | CCDC88A | S1425 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q3ZCM7 | TUBB8 | S275 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q4V328 | GRIPAP1 | S688 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q504U0 | C4orf46 | S19 | ochoa | Renal cancer differentiation gene 1 protein | None |
| Q53T59 | HS1BP3 | S147 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5T5C0 | STXBP5 | S688 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T5C0 | STXBP5 | S778 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T5P2 | KIAA1217 | S1892 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TBA9 | FRY | S1936 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5VZ89 | DENND4C | S996 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HQ0 | AP1AR | S171 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q6P0N0 | MIS18BP1 | S131 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P3S1 | DENND1B | S576 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6PKG0 | LARP1 | S577 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6QNY0 | BLOC1S3 | S30 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| Q6Y7W6 | GIGYF2 | S374 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZS17 | RIPOR1 | S330 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZT07 | TBC1D9 | S415 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZU65 | UBN2 | S1088 | ochoa | Ubinuclein-2 | None |
| Q6ZUJ8 | PIK3AP1 | S727 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7Z5J4 | RAI1 | S1119 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86SQ0 | PHLDB2 | S562 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86V48 | LUZP1 | S801 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XZ4 | SPATS2 | S382 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IVF2 | AHNAK2 | S278 | ochoa | Protein AHNAK2 | None |
| Q8IWB9 | TEX2 | S744 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IWQ3 | BRSK2 | S410 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
| Q8IWS0 | PHF6 | S181 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IX01 | SUGP2 | S89 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IY57 | YAF2 | S151 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IYB3 | SRRM1 | S773 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZP0 | ABI1 | S319 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8NCG7 | DAGLB | S175 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8NDI1 | EHBP1 | S656 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFH8 | REPS2 | S489 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q92608 | DOCK2 | S583 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92625 | ANKS1A | S620 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92633 | LPAR1 | S344 | ochoa | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) | Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}. |
| Q92667 | AKAP1 | S441 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92793 | CREBBP | S2061 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92918 | MAP4K1 | S444 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92934 | BAD | S71 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q96A57 | TMEM230 | S20 | ochoa | Transmembrane protein 230 | Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}. |
| Q96B97 | SH3KBP1 | S495 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96BY7 | ATG2B | S493 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96D71 | REPS1 | S558 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96HA1 | POM121 | S378 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HA1 | POM121 | S389 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96NE9 | FRMD6 | S411 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96R06 | SPAG5 | S397 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RT1 | ERBIN | S1140 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96SD1 | DCLRE1C | S645 | psp | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q99501 | GAS2L1 | S486 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99569 | PKP4 | S388 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BQ89 | FAM110A | S249 | ochoa | Protein FAM110A | None |
| Q9BUF5 | TUBB6 | S275 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BUL5 | PHF23 | S60 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BVA1 | TUBB2B | S275 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXB4 | OSBPL11 | S170 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9BXL7 | CARD11 | S556 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BZL4 | PPP1R12C | S450 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0D5 | TANC1 | S300 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0H2 | TTYH3 | S500 | ochoa | Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q6P5F7, ECO:0000269|PubMed:15010458}. |
| Q9C0H5 | ARHGAP39 | S169 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9GZV5 | WWTR1 | S87 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9GZV5 | WWTR1 | S307 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H3Q1 | CDC42EP4 | S70 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4E7 | DEF6 | S564 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H5J8 | TAF1D | S23 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6A9 | PCNX3 | S704 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6K5 | PRR36 | S1107 | ochoa | Proline-rich protein 36 | None |
| Q9H8W4 | PLEKHF2 | S224 | ochoa | Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18) | May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}. |
| Q9HB20 | PLEKHA3 | S218 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
| Q9HCD6 | TANC2 | Y1454 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HDC5 | JPH1 | S574 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQ84 | GPRC5C | S403 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NV70 | EXOC1 | S487 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NYL2 | MAP3K20 | S633 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYV6 | RRN3 | S633 | ochoa|psp | RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) | Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}. |
| Q9NZ52 | GGA3 | S368 | psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9P0K7 | RAI14 | S286 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L2 | MARK1 | S390 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P206 | NHSL3 | S566 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P219 | CCDC88C | S1568 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P270 | SLAIN2 | S247 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2D6 | FAM135A | S636 | ochoa | Protein FAM135A | None |
| Q9UGV2 | NDRG3 | S327 | ochoa | Protein NDRG3 (N-myc downstream-regulated gene 3 protein) | None |
| Q9UHB7 | AFF4 | S176 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UKF7 | PITPNC1 | S270 | ochoa | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) | [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}. |
| Q9UKI8 | TLK1 | S174 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULT8 | HECTD1 | S1567 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMS6 | SYNPO2 | S1061 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UN36 | NDRG2 | S328 | ochoa | Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}. |
| Q9UPN3 | MACF1 | S7234 | ochoa|psp | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN3 | MACF1 | S7288 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UQ35 | SRRM2 | S950 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y210 | TRPC6 | S836 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y263 | PLAA | S481 | ochoa | Phospholipase A-2-activating protein (PLA2P) (PLAP) | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}. |
| Q9Y446 | PKP3 | S220 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4H2 | IRS2 | S665 | psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5P4 | CERT1 | S373 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y5S2 | CDC42BPB | S1640 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6Y0 | IVNS1ABP | S334 | ochoa | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201). {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}. |
| O15111 | CHUK | S400 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| Q9H6T3 | RPAP3 | S503 | Sugiyama | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.018736e-08 | 7.992 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.132400e-08 | 7.946 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.530480e-08 | 7.815 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.631380e-07 | 6.787 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.121729e-07 | 6.506 |
| R-HSA-190828 | Gap junction trafficking | 2.546678e-07 | 6.594 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.049185e-07 | 6.297 |
| R-HSA-162582 | Signal Transduction | 4.662309e-07 | 6.331 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.264040e-07 | 6.279 |
| R-HSA-190861 | Gap junction assembly | 7.324104e-07 | 6.135 |
| R-HSA-9833482 | PKR-mediated signaling | 1.311939e-06 | 5.882 |
| R-HSA-68877 | Mitotic Prometaphase | 1.819849e-06 | 5.740 |
| R-HSA-9646399 | Aggrephagy | 1.795421e-06 | 5.746 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.233722e-06 | 5.651 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.648742e-06 | 5.577 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.985023e-06 | 5.302 |
| R-HSA-437239 | Recycling pathway of L1 | 4.985023e-06 | 5.302 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.517727e-06 | 5.258 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.794612e-06 | 5.237 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.606219e-06 | 5.180 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.799861e-06 | 5.108 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.683948e-06 | 5.014 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.191770e-05 | 4.924 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.195637e-05 | 4.922 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.390143e-05 | 4.857 |
| R-HSA-983189 | Kinesins | 1.936148e-05 | 4.713 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.325376e-05 | 4.634 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.810739e-05 | 4.551 |
| R-HSA-373760 | L1CAM interactions | 2.881850e-05 | 4.540 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.298429e-05 | 4.482 |
| R-HSA-9675108 | Nervous system development | 3.543616e-05 | 4.451 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.897693e-05 | 4.409 |
| R-HSA-422475 | Axon guidance | 4.784388e-05 | 4.320 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.149884e-05 | 4.146 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.807026e-05 | 4.055 |
| R-HSA-68886 | M Phase | 1.017320e-04 | 3.993 |
| R-HSA-68882 | Mitotic Anaphase | 1.323265e-04 | 3.878 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.372309e-04 | 3.863 |
| R-HSA-9663891 | Selective autophagy | 1.748810e-04 | 3.757 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.771525e-04 | 3.752 |
| R-HSA-69275 | G2/M Transition | 1.864091e-04 | 3.730 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.013196e-04 | 3.696 |
| R-HSA-5617833 | Cilium Assembly | 2.172204e-04 | 3.663 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.352252e-04 | 3.629 |
| R-HSA-9609690 | HCMV Early Events | 2.713905e-04 | 3.566 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.150421e-04 | 3.502 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.150421e-04 | 3.502 |
| R-HSA-5620924 | Intraflagellar transport | 5.842842e-04 | 3.233 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.572525e-04 | 3.254 |
| R-HSA-4839744 | Signaling by APC mutants | 6.548315e-04 | 3.184 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 6.548315e-04 | 3.184 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 6.548315e-04 | 3.184 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 6.548315e-04 | 3.184 |
| R-HSA-1632852 | Macroautophagy | 6.438713e-04 | 3.191 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 7.984842e-04 | 3.098 |
| R-HSA-4839735 | Signaling by AXIN mutants | 7.984842e-04 | 3.098 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 7.984842e-04 | 3.098 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.993834e-04 | 3.097 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 9.607308e-04 | 3.017 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 9.607308e-04 | 3.017 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 9.607308e-04 | 3.017 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 9.607308e-04 | 3.017 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 9.607308e-04 | 3.017 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.440794e-04 | 3.025 |
| R-HSA-199991 | Membrane Trafficking | 1.051203e-03 | 2.978 |
| R-HSA-913531 | Interferon Signaling | 1.126685e-03 | 2.948 |
| R-HSA-9612973 | Autophagy | 1.189011e-03 | 2.925 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.324706e-03 | 2.878 |
| R-HSA-109582 | Hemostasis | 1.449615e-03 | 2.839 |
| R-HSA-9609646 | HCMV Infection | 1.523826e-03 | 2.817 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.567699e-03 | 2.805 |
| R-HSA-8853659 | RET signaling | 1.802892e-03 | 2.744 |
| R-HSA-1280218 | Adaptive Immune System | 1.863715e-03 | 2.730 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.748576e-03 | 2.757 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.908503e-03 | 2.719 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.042977e-03 | 2.690 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.204349e-03 | 2.657 |
| R-HSA-1640170 | Cell Cycle | 2.670489e-03 | 2.573 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.705905e-03 | 2.431 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.805198e-03 | 2.318 |
| R-HSA-9824446 | Viral Infection Pathways | 4.703968e-03 | 2.328 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.097889e-03 | 2.293 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 5.115249e-03 | 2.291 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.940429e-03 | 2.226 |
| R-HSA-8875656 | MET receptor recycling | 7.694237e-03 | 2.114 |
| R-HSA-391251 | Protein folding | 7.605658e-03 | 2.119 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 7.283545e-03 | 2.138 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 7.694237e-03 | 2.114 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 7.283545e-03 | 2.138 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.043388e-03 | 2.095 |
| R-HSA-1266738 | Developmental Biology | 8.674766e-03 | 2.062 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 9.216741e-03 | 2.035 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.720734e-03 | 2.012 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.040067e-02 | 1.983 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.040067e-02 | 1.983 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.173007e-02 | 1.931 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.194634e-02 | 1.923 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.065641e-02 | 1.972 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.142227e-02 | 1.942 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.141512e-02 | 1.943 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.065641e-02 | 1.972 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.073193e-02 | 1.969 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.217908e-02 | 1.914 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 1.217908e-02 | 1.914 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.238128e-02 | 1.907 |
| R-HSA-5673000 | RAF activation | 1.304708e-02 | 1.884 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.304708e-02 | 1.884 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.315179e-02 | 1.881 |
| R-HSA-418346 | Platelet homeostasis | 1.357966e-02 | 1.867 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.566510e-02 | 1.805 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.610486e-02 | 1.793 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.422596e-02 | 1.847 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.566510e-02 | 1.805 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.566510e-02 | 1.805 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.566510e-02 | 1.805 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.537888e-02 | 1.813 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.666536e-02 | 1.778 |
| R-HSA-380287 | Centrosome maturation | 1.744000e-02 | 1.758 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.754944e-02 | 1.756 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.765966e-02 | 1.753 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.765966e-02 | 1.753 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.884655e-02 | 1.725 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.952477e-02 | 1.709 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.960652e-02 | 1.708 |
| R-HSA-9679506 | SARS-CoV Infections | 1.991332e-02 | 1.701 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.158871e-02 | 1.666 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.158871e-02 | 1.666 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.158871e-02 | 1.666 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.192283e-02 | 1.659 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.332326e-02 | 1.632 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.332326e-02 | 1.632 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.373895e-02 | 1.625 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.429095e-02 | 1.615 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.402783e-02 | 1.619 |
| R-HSA-3371556 | Cellular response to heat stress | 2.274037e-02 | 1.643 |
| R-HSA-75153 | Apoptotic execution phase | 2.669817e-02 | 1.574 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.828919e-02 | 1.548 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.927755e-02 | 1.533 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.964395e-02 | 1.528 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.060211e-02 | 1.514 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 3.068474e-02 | 1.513 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.068474e-02 | 1.513 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.068474e-02 | 1.513 |
| R-HSA-112316 | Neuronal System | 3.156071e-02 | 1.501 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.315769e-02 | 1.479 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.338485e-02 | 1.476 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.370934e-02 | 1.472 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.478116e-02 | 1.459 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.478116e-02 | 1.459 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.481711e-02 | 1.458 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.570590e-02 | 1.447 |
| R-HSA-445144 | Signal transduction by L1 | 3.570590e-02 | 1.447 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.570590e-02 | 1.447 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.610534e-02 | 1.336 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.610534e-02 | 1.336 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.610534e-02 | 1.336 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.610534e-02 | 1.336 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.610534e-02 | 1.336 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.610534e-02 | 1.336 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.610534e-02 | 1.336 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.610534e-02 | 1.336 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.610534e-02 | 1.336 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.610534e-02 | 1.336 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.610534e-02 | 1.336 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.378147e-02 | 1.359 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.319659e-02 | 1.365 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.930166e-02 | 1.406 |
| R-HSA-177929 | Signaling by EGFR | 4.085864e-02 | 1.389 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.085864e-02 | 1.389 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.001362e-02 | 1.398 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.872277e-02 | 1.412 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.661027e-02 | 1.332 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.663182e-02 | 1.331 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.739285e-02 | 1.324 |
| R-HSA-5663205 | Infectious disease | 4.767098e-02 | 1.322 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.835196e-02 | 1.316 |
| R-HSA-9707616 | Heme signaling | 5.084114e-02 | 1.294 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.222088e-02 | 1.282 |
| R-HSA-9839394 | TGFBR3 expression | 5.246160e-02 | 1.280 |
| R-HSA-9830364 | Formation of the nephric duct | 5.246160e-02 | 1.280 |
| R-HSA-168256 | Immune System | 5.403862e-02 | 1.267 |
| R-HSA-3295583 | TRP channels | 5.548037e-02 | 1.256 |
| R-HSA-8865999 | MET activates PTPN11 | 5.729736e-02 | 1.242 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 6.835874e-02 | 1.165 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 6.835874e-02 | 1.165 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 6.835874e-02 | 1.165 |
| R-HSA-74713 | IRS activation | 7.929101e-02 | 1.101 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 7.929101e-02 | 1.101 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 9.009566e-02 | 1.045 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.007742e-01 | 0.997 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.113280e-01 | 0.953 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.113280e-01 | 0.953 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.113280e-01 | 0.953 |
| R-HSA-112412 | SOS-mediated signalling | 1.113280e-01 | 0.953 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.217586e-01 | 0.915 |
| R-HSA-196025 | Formation of annular gap junctions | 1.217586e-01 | 0.915 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.217586e-01 | 0.915 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.320675e-01 | 0.879 |
| R-HSA-190873 | Gap junction degradation | 1.320675e-01 | 0.879 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.320675e-01 | 0.879 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.422559e-01 | 0.847 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.422559e-01 | 0.847 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.622773e-01 | 0.790 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 5.855876e-02 | 1.232 |
| R-HSA-9006335 | Signaling by Erythropoietin | 6.488721e-02 | 1.188 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 6.813379e-02 | 1.167 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 7.143299e-02 | 1.146 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 7.143299e-02 | 1.146 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.009360e-01 | 0.697 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.009360e-01 | 0.697 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 7.818263e-02 | 1.107 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 7.818263e-02 | 1.107 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 8.162984e-02 | 1.088 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.103200e-01 | 0.677 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.866114e-02 | 1.052 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.032292e-01 | 0.986 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.069680e-01 | 0.971 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.187663e-02 | 1.143 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 9.152116e-02 | 1.038 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.583797e-01 | 0.800 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.008946e-01 | 0.996 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.008946e-01 | 0.996 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.834225e-01 | 0.737 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.132871e-01 | 0.671 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 1.032292e-01 | 0.986 |
| R-HSA-198203 | PI3K/AKT activation | 1.422559e-01 | 0.847 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.422559e-01 | 0.847 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.195945e-01 | 0.658 |
| R-HSA-4641265 | Repression of WNT target genes | 1.721130e-01 | 0.764 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.721130e-01 | 0.764 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.145522e-01 | 0.941 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.340729e-01 | 0.873 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.340729e-01 | 0.873 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.340729e-01 | 0.873 |
| R-HSA-73864 | RNA Polymerase I Transcription | 8.253495e-02 | 1.083 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.819324e-02 | 1.107 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.461199e-01 | 0.835 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.340729e-01 | 0.873 |
| R-HSA-75893 | TNF signaling | 1.750068e-01 | 0.757 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 6.835874e-02 | 1.165 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.113280e-01 | 0.953 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.523254e-01 | 0.817 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.622773e-01 | 0.790 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.918962e-01 | 0.717 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.918962e-01 | 0.717 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.918962e-01 | 0.717 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.918962e-01 | 0.717 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.445709e-01 | 0.840 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 6.813379e-02 | 1.167 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.914410e-01 | 0.718 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.103200e-01 | 0.677 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.340729e-01 | 0.873 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.103200e-01 | 0.677 |
| R-HSA-202424 | Downstream TCR signaling | 1.131250e-01 | 0.946 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 8.866114e-02 | 1.052 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.729736e-02 | 1.242 |
| R-HSA-8866376 | Reelin signalling pathway | 7.929101e-02 | 1.101 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.009566e-02 | 1.045 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.217586e-01 | 0.915 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.320675e-01 | 0.879 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.422559e-01 | 0.847 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.622773e-01 | 0.790 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.721130e-01 | 0.764 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.009360e-01 | 0.697 |
| R-HSA-1566977 | Fibronectin matrix formation | 2.195945e-01 | 0.658 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 9.586484e-02 | 1.018 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.301098e-01 | 0.886 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.961525e-01 | 0.707 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.258878e-01 | 0.900 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.046996e-01 | 0.689 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 1.183949e-01 | 0.927 |
| R-HSA-182971 | EGFR downregulation | 7.143299e-02 | 1.146 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.113280e-01 | 0.953 |
| R-HSA-112399 | IRS-mediated signalling | 1.792070e-01 | 0.747 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.217586e-01 | 0.915 |
| R-HSA-74749 | Signal attenuation | 1.422559e-01 | 0.847 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.069680e-01 | 0.971 |
| R-HSA-5260271 | Diseases of Immune System | 1.069680e-01 | 0.971 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 1.232946e-01 | 0.909 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 6.488721e-02 | 1.188 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.217586e-01 | 0.915 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 7.478315e-02 | 1.126 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 8.162984e-02 | 1.088 |
| R-HSA-114604 | GPVI-mediated activation cascade | 9.224219e-02 | 1.035 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.337837e-01 | 0.874 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.089887e-01 | 0.680 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 9.586484e-02 | 1.018 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.876526e-01 | 0.727 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.089887e-01 | 0.680 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.007742e-01 | 0.997 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.217586e-01 | 0.915 |
| R-HSA-426048 | Arachidonate production from DAG | 1.422559e-01 | 0.847 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.622773e-01 | 0.790 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.580204e-02 | 1.182 |
| R-HSA-191859 | snRNP Assembly | 1.876526e-01 | 0.727 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.876526e-01 | 0.727 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.961525e-01 | 0.707 |
| R-HSA-6809371 | Formation of the cornified envelope | 2.235528e-01 | 0.651 |
| R-HSA-73887 | Death Receptor Signaling | 1.472684e-01 | 0.832 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.132871e-01 | 0.671 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.422559e-01 | 0.847 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.918962e-01 | 0.717 |
| R-HSA-6806834 | Signaling by MET | 8.697840e-02 | 1.061 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.880287e-01 | 0.726 |
| R-HSA-373755 | Semaphorin interactions | 2.046996e-01 | 0.689 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.219086e-01 | 0.654 |
| R-HSA-202403 | TCR signaling | 5.757823e-02 | 1.240 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.007742e-01 | 0.997 |
| R-HSA-180746 | Nuclear import of Rev protein | 8.512319e-02 | 1.070 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.750068e-01 | 0.757 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.195945e-01 | 0.658 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.285006e-01 | 0.891 |
| R-HSA-195721 | Signaling by WNT | 1.755992e-01 | 0.755 |
| R-HSA-9927353 | Co-inhibition by BTLA | 7.929101e-02 | 1.101 |
| R-HSA-1462054 | Alpha-defensins | 1.217586e-01 | 0.915 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.320675e-01 | 0.879 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.320675e-01 | 0.879 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.721130e-01 | 0.764 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.721130e-01 | 0.764 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.721130e-01 | 0.764 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.721130e-01 | 0.764 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.914410e-01 | 0.718 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.009360e-01 | 0.697 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.103200e-01 | 0.677 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.069680e-01 | 0.971 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.069680e-01 | 0.971 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.107428e-01 | 0.956 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.542713e-01 | 0.812 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.364574e-01 | 0.865 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 8.162984e-02 | 1.088 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.809177e-02 | 1.236 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.918962e-01 | 0.717 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.320675e-01 | 0.879 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 6.813379e-02 | 1.167 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 9.586484e-02 | 1.018 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 9.586484e-02 | 1.018 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.929101e-02 | 1.101 |
| R-HSA-164944 | Nef and signal transduction | 1.007742e-01 | 0.997 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.217586e-01 | 0.915 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.721130e-01 | 0.764 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.721130e-01 | 0.764 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.721130e-01 | 0.764 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.914410e-01 | 0.718 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.914410e-01 | 0.718 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 9.952764e-02 | 1.002 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.340729e-01 | 0.873 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 7.478315e-02 | 1.126 |
| R-HSA-5357801 | Programmed Cell Death | 1.290541e-01 | 0.889 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.253495e-02 | 1.083 |
| R-HSA-74160 | Gene expression (Transcription) | 1.860047e-01 | 0.730 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.604081e-01 | 0.795 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 9.009566e-02 | 1.045 |
| R-HSA-5689877 | Josephin domain DUBs | 1.422559e-01 | 0.847 |
| R-HSA-5578768 | Physiological factors | 1.914410e-01 | 0.718 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.195945e-01 | 0.658 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.032292e-01 | 0.986 |
| R-HSA-109704 | PI3K Cascade | 1.501843e-01 | 0.823 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.721730e-01 | 0.764 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.616935e-02 | 1.017 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.792070e-01 | 0.747 |
| R-HSA-2262752 | Cellular responses to stress | 1.085946e-01 | 0.964 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.422559e-01 | 0.847 |
| R-HSA-210990 | PECAM1 interactions | 1.523254e-01 | 0.817 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.009360e-01 | 0.697 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.004206e-01 | 0.698 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.500695e-01 | 0.824 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.022274e-01 | 0.694 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.364534e-01 | 0.865 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.455010e-01 | 0.837 |
| R-HSA-2980736 | Peptide hormone metabolism | 2.022274e-01 | 0.694 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.340729e-01 | 0.873 |
| R-HSA-5688426 | Deubiquitination | 1.087988e-01 | 0.963 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.914410e-01 | 0.718 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.698201e-01 | 0.770 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.511362e-02 | 1.124 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.604505e-01 | 0.795 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.189577e-01 | 0.925 |
| R-HSA-9748787 | Azathioprine ADME | 1.501843e-01 | 0.823 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.235528e-01 | 0.651 |
| R-HSA-109581 | Apoptosis | 6.344623e-02 | 1.198 |
| R-HSA-2586552 | Signaling by Leptin | 1.422559e-01 | 0.847 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.420791e-01 | 0.847 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.217586e-01 | 0.915 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.320675e-01 | 0.879 |
| R-HSA-9842663 | Signaling by LTK | 1.721130e-01 | 0.764 |
| R-HSA-1643685 | Disease | 7.143436e-02 | 1.146 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.903936e-01 | 0.720 |
| R-HSA-68875 | Mitotic Prophase | 2.113088e-01 | 0.675 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.580204e-02 | 1.182 |
| R-HSA-9830369 | Kidney development | 2.219086e-01 | 0.654 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.420791e-01 | 0.847 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.082715e-01 | 0.681 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.145522e-01 | 0.941 |
| R-HSA-9758941 | Gastrulation | 1.366245e-01 | 0.864 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.222695e-01 | 0.913 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.606128e-02 | 1.119 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.156363e-01 | 0.937 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.552997e-01 | 0.809 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.287606e-01 | 0.641 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.287606e-01 | 0.641 |
| R-HSA-2028269 | Signaling by Hippo | 2.287606e-01 | 0.641 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.287606e-01 | 0.641 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.287606e-01 | 0.641 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.287606e-01 | 0.641 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.287606e-01 | 0.641 |
| R-HSA-983712 | Ion channel transport | 2.319230e-01 | 0.635 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.326491e-01 | 0.633 |
| R-HSA-449147 | Signaling by Interleukins | 2.343909e-01 | 0.630 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.348910e-01 | 0.629 |
| R-HSA-180292 | GAB1 signalosome | 2.378196e-01 | 0.624 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.378196e-01 | 0.624 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.392288e-01 | 0.621 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.394786e-01 | 0.621 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.435707e-01 | 0.613 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 2.435707e-01 | 0.613 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.467727e-01 | 0.608 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.467727e-01 | 0.608 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.467727e-01 | 0.608 |
| R-HSA-392517 | Rap1 signalling | 2.467727e-01 | 0.608 |
| R-HSA-9834899 | Specification of the neural plate border | 2.467727e-01 | 0.608 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.479159e-01 | 0.606 |
| R-HSA-1474165 | Reproduction | 2.484327e-01 | 0.605 |
| R-HSA-9843745 | Adipogenesis | 2.515736e-01 | 0.599 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.522638e-01 | 0.598 |
| R-HSA-9909396 | Circadian clock | 2.547205e-01 | 0.594 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.556213e-01 | 0.592 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.556213e-01 | 0.592 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.556213e-01 | 0.592 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.556213e-01 | 0.592 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.556213e-01 | 0.592 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.556213e-01 | 0.592 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.556213e-01 | 0.592 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.556213e-01 | 0.592 |
| R-HSA-1181150 | Signaling by NODAL | 2.556213e-01 | 0.592 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.566136e-01 | 0.591 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.609649e-01 | 0.583 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.643664e-01 | 0.578 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.643664e-01 | 0.578 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.643664e-01 | 0.578 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.643664e-01 | 0.578 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.643664e-01 | 0.578 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 2.643664e-01 | 0.578 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.643664e-01 | 0.578 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.643664e-01 | 0.578 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.676403e-01 | 0.572 |
| R-HSA-216083 | Integrin cell surface interactions | 2.696689e-01 | 0.569 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.710554e-01 | 0.567 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.730093e-01 | 0.564 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.730093e-01 | 0.564 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.730093e-01 | 0.564 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.730093e-01 | 0.564 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.730093e-01 | 0.564 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.730093e-01 | 0.564 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.730093e-01 | 0.564 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.730093e-01 | 0.564 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.740205e-01 | 0.562 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.789872e-01 | 0.554 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.815512e-01 | 0.550 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.815512e-01 | 0.550 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.827200e-01 | 0.549 |
| R-HSA-977225 | Amyloid fiber formation | 2.827200e-01 | 0.549 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.827200e-01 | 0.549 |
| R-HSA-9664407 | Parasite infection | 2.832639e-01 | 0.548 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.832639e-01 | 0.548 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.832639e-01 | 0.548 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.899932e-01 | 0.538 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.899932e-01 | 0.538 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.899932e-01 | 0.538 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.899932e-01 | 0.538 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.914108e-01 | 0.535 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.963669e-01 | 0.528 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.983366e-01 | 0.525 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.983366e-01 | 0.525 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.983366e-01 | 0.525 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.983366e-01 | 0.525 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.983366e-01 | 0.525 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.992467e-01 | 0.524 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.000885e-01 | 0.523 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.044211e-01 | 0.517 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.065824e-01 | 0.513 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.065824e-01 | 0.513 |
| R-HSA-9620244 | Long-term potentiation | 3.065824e-01 | 0.513 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.065824e-01 | 0.513 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.087490e-01 | 0.510 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.120700e-01 | 0.506 |
| R-HSA-166520 | Signaling by NTRKs | 3.120700e-01 | 0.506 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.147318e-01 | 0.502 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.147318e-01 | 0.502 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.147318e-01 | 0.502 |
| R-HSA-525793 | Myogenesis | 3.147318e-01 | 0.502 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.147318e-01 | 0.502 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.147318e-01 | 0.502 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.173885e-01 | 0.498 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.184886e-01 | 0.497 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.216989e-01 | 0.493 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.216992e-01 | 0.493 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.227860e-01 | 0.491 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.227860e-01 | 0.491 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.227860e-01 | 0.491 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.227860e-01 | 0.491 |
| R-HSA-264876 | Insulin processing | 3.227860e-01 | 0.491 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.227860e-01 | 0.491 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 3.260032e-01 | 0.487 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.281201e-01 | 0.484 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.307460e-01 | 0.481 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.307460e-01 | 0.481 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 3.307460e-01 | 0.481 |
| R-HSA-162906 | HIV Infection | 3.334367e-01 | 0.477 |
| R-HSA-1989781 | PPARA activates gene expression | 3.345408e-01 | 0.476 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.386129e-01 | 0.470 |
| R-HSA-420092 | Glucagon-type ligand receptors | 3.386129e-01 | 0.470 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.386129e-01 | 0.470 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.386129e-01 | 0.470 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.386129e-01 | 0.470 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.388711e-01 | 0.470 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.409593e-01 | 0.467 |
| R-HSA-162587 | HIV Life Cycle | 3.409593e-01 | 0.467 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.463878e-01 | 0.460 |
| R-HSA-2424491 | DAP12 signaling | 3.463878e-01 | 0.460 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.463878e-01 | 0.460 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.463878e-01 | 0.460 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.463878e-01 | 0.460 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.463878e-01 | 0.460 |
| R-HSA-112311 | Neurotransmitter clearance | 3.463878e-01 | 0.460 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.504427e-01 | 0.455 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.520762e-01 | 0.453 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.540718e-01 | 0.451 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.540718e-01 | 0.451 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.601463e-01 | 0.444 |
| R-HSA-1500931 | Cell-Cell communication | 3.641429e-01 | 0.439 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.691712e-01 | 0.433 |
| R-HSA-354192 | Integrin signaling | 3.691712e-01 | 0.433 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.691712e-01 | 0.433 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.691712e-01 | 0.433 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.691712e-01 | 0.433 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.691712e-01 | 0.433 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.691712e-01 | 0.433 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.691712e-01 | 0.433 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.691712e-01 | 0.433 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.724450e-01 | 0.429 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.727922e-01 | 0.429 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.727922e-01 | 0.429 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.765888e-01 | 0.424 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.765888e-01 | 0.424 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.765888e-01 | 0.424 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.765888e-01 | 0.424 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.765888e-01 | 0.424 |
| R-HSA-70171 | Glycolysis | 3.769855e-01 | 0.424 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.839195e-01 | 0.416 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.839195e-01 | 0.416 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.839195e-01 | 0.416 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.839195e-01 | 0.416 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.839195e-01 | 0.416 |
| R-HSA-418555 | G alpha (s) signalling events | 3.888584e-01 | 0.410 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.911645e-01 | 0.408 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.911645e-01 | 0.408 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.911645e-01 | 0.408 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.911645e-01 | 0.408 |
| R-HSA-4839726 | Chromatin organization | 3.919980e-01 | 0.407 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.936409e-01 | 0.405 |
| R-HSA-212436 | Generic Transcription Pathway | 3.971720e-01 | 0.401 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.977738e-01 | 0.400 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.977738e-01 | 0.400 |
| R-HSA-9833110 | RSV-host interactions | 3.977738e-01 | 0.400 |
| R-HSA-111933 | Calmodulin induced events | 3.983248e-01 | 0.400 |
| R-HSA-111997 | CaM pathway | 3.983248e-01 | 0.400 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.983248e-01 | 0.400 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.983248e-01 | 0.400 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.983248e-01 | 0.400 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.983248e-01 | 0.400 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.983532e-01 | 0.400 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.018937e-01 | 0.396 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.054013e-01 | 0.392 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.054013e-01 | 0.392 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.054013e-01 | 0.392 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.060004e-01 | 0.391 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.100936e-01 | 0.387 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.100936e-01 | 0.387 |
| R-HSA-211000 | Gene Silencing by RNA | 4.100936e-01 | 0.387 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.123949e-01 | 0.385 |
| R-HSA-8875878 | MET promotes cell motility | 4.123949e-01 | 0.385 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.123949e-01 | 0.385 |
| R-HSA-1566948 | Elastic fibre formation | 4.123949e-01 | 0.385 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.141731e-01 | 0.383 |
| R-HSA-201556 | Signaling by ALK | 4.193068e-01 | 0.377 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.222899e-01 | 0.374 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.222899e-01 | 0.374 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.261378e-01 | 0.370 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.261378e-01 | 0.370 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.261378e-01 | 0.370 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.261378e-01 | 0.370 |
| R-HSA-3371568 | Attenuation phase | 4.261378e-01 | 0.370 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.261378e-01 | 0.370 |
| R-HSA-202433 | Generation of second messenger molecules | 4.261378e-01 | 0.370 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.261378e-01 | 0.370 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.303491e-01 | 0.366 |
| R-HSA-416476 | G alpha (q) signalling events | 4.315691e-01 | 0.365 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.328888e-01 | 0.364 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.328888e-01 | 0.364 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.328888e-01 | 0.364 |
| R-HSA-9607240 | FLT3 Signaling | 4.328888e-01 | 0.364 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.383488e-01 | 0.358 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.383488e-01 | 0.358 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.395608e-01 | 0.357 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.395608e-01 | 0.357 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.395608e-01 | 0.357 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.395608e-01 | 0.357 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.420165e-01 | 0.355 |
| R-HSA-165159 | MTOR signalling | 4.461548e-01 | 0.351 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.461548e-01 | 0.351 |
| R-HSA-111996 | Ca-dependent events | 4.461548e-01 | 0.351 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.461548e-01 | 0.351 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.502335e-01 | 0.347 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.512867e-01 | 0.346 |
| R-HSA-1461973 | Defensins | 4.526715e-01 | 0.344 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.526715e-01 | 0.344 |
| R-HSA-8854214 | TBC/RABGAPs | 4.526715e-01 | 0.344 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.580778e-01 | 0.339 |
| R-HSA-70326 | Glucose metabolism | 4.580778e-01 | 0.339 |
| R-HSA-2172127 | DAP12 interactions | 4.591120e-01 | 0.338 |
| R-HSA-373752 | Netrin-1 signaling | 4.591120e-01 | 0.338 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.591120e-01 | 0.338 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.604410e-01 | 0.337 |
| R-HSA-5693538 | Homology Directed Repair | 4.619758e-01 | 0.335 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.654771e-01 | 0.332 |
| R-HSA-774815 | Nucleosome assembly | 4.654771e-01 | 0.332 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.654771e-01 | 0.332 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.654771e-01 | 0.332 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.654771e-01 | 0.332 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.654771e-01 | 0.332 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.658575e-01 | 0.332 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.658575e-01 | 0.332 |
| R-HSA-9675135 | Diseases of DNA repair | 4.717677e-01 | 0.326 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.735713e-01 | 0.325 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.774031e-01 | 0.321 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.774031e-01 | 0.321 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.779846e-01 | 0.321 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.779846e-01 | 0.321 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.779846e-01 | 0.321 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.812180e-01 | 0.318 |
| R-HSA-9634597 | GPER1 signaling | 4.841287e-01 | 0.315 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.841287e-01 | 0.315 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.902009e-01 | 0.310 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 4.902009e-01 | 0.310 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.925601e-01 | 0.308 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.925601e-01 | 0.308 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.925601e-01 | 0.308 |
| R-HSA-194138 | Signaling by VEGF | 4.925601e-01 | 0.308 |
| R-HSA-72172 | mRNA Splicing | 4.934265e-01 | 0.307 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.962020e-01 | 0.304 |
| R-HSA-6805567 | Keratinization | 4.993185e-01 | 0.302 |
| R-HSA-114608 | Platelet degranulation | 5.000346e-01 | 0.301 |
| R-HSA-69481 | G2/M Checkpoints | 5.000346e-01 | 0.301 |
| R-HSA-912446 | Meiotic recombination | 5.021328e-01 | 0.299 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.037455e-01 | 0.298 |
| R-HSA-72187 | mRNA 3'-end processing | 5.079942e-01 | 0.294 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.079942e-01 | 0.294 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.079942e-01 | 0.294 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.079942e-01 | 0.294 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.079942e-01 | 0.294 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.137869e-01 | 0.289 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.137869e-01 | 0.289 |
| R-HSA-1221632 | Meiotic synapsis | 5.137869e-01 | 0.289 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.137869e-01 | 0.289 |
| R-HSA-597592 | Post-translational protein modification | 5.179779e-01 | 0.286 |
| R-HSA-5576891 | Cardiac conduction | 5.184110e-01 | 0.285 |
| R-HSA-9753281 | Paracetamol ADME | 5.251696e-01 | 0.280 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.251696e-01 | 0.280 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.256356e-01 | 0.279 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.307612e-01 | 0.275 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.307612e-01 | 0.275 |
| R-HSA-5578775 | Ion homeostasis | 5.307612e-01 | 0.275 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.398655e-01 | 0.268 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.417485e-01 | 0.266 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.433770e-01 | 0.265 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.471458e-01 | 0.262 |
| R-HSA-186712 | Regulation of beta-cell development | 5.471458e-01 | 0.262 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.524799e-01 | 0.258 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.524799e-01 | 0.258 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.524799e-01 | 0.258 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.562368e-01 | 0.255 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.572368e-01 | 0.254 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.577515e-01 | 0.254 |
| R-HSA-112043 | PLC beta mediated events | 5.577515e-01 | 0.254 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.577515e-01 | 0.254 |
| R-HSA-450294 | MAP kinase activation | 5.577515e-01 | 0.254 |
| R-HSA-186797 | Signaling by PDGF | 5.629613e-01 | 0.250 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.629613e-01 | 0.250 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.640545e-01 | 0.249 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 5.731984e-01 | 0.242 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.731984e-01 | 0.242 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.731984e-01 | 0.242 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.778496e-01 | 0.238 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.782272e-01 | 0.238 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.858606e-01 | 0.232 |
| R-HSA-8939211 | ESR-mediated signaling | 5.858606e-01 | 0.232 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.881086e-01 | 0.231 |
| R-HSA-112040 | G-protein mediated events | 5.881086e-01 | 0.231 |
| R-HSA-372790 | Signaling by GPCR | 5.907692e-01 | 0.229 |
| R-HSA-5218859 | Regulated Necrosis | 5.929626e-01 | 0.227 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.970124e-01 | 0.224 |
| R-HSA-388396 | GPCR downstream signalling | 5.976912e-01 | 0.224 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.025005e-01 | 0.220 |
| R-HSA-448424 | Interleukin-17 signaling | 6.025005e-01 | 0.220 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.033769e-01 | 0.219 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.065308e-01 | 0.217 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.071857e-01 | 0.217 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.071857e-01 | 0.217 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.071857e-01 | 0.217 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.071857e-01 | 0.217 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.118161e-01 | 0.213 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.118161e-01 | 0.213 |
| R-HSA-9610379 | HCMV Late Events | 6.127817e-01 | 0.213 |
| R-HSA-4086398 | Ca2+ pathway | 6.163921e-01 | 0.210 |
| R-HSA-877300 | Interferon gamma signaling | 6.189570e-01 | 0.208 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.209145e-01 | 0.207 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.209145e-01 | 0.207 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.209145e-01 | 0.207 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.209145e-01 | 0.207 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.220163e-01 | 0.206 |
| R-HSA-8852135 | Protein ubiquitination | 6.253838e-01 | 0.204 |
| R-HSA-5689603 | UCH proteinases | 6.298007e-01 | 0.201 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.341658e-01 | 0.198 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.384797e-01 | 0.195 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.384797e-01 | 0.195 |
| R-HSA-5619102 | SLC transporter disorders | 6.429042e-01 | 0.192 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.469563e-01 | 0.189 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.469563e-01 | 0.189 |
| R-HSA-72306 | tRNA processing | 6.544283e-01 | 0.184 |
| R-HSA-73894 | DNA Repair | 6.579426e-01 | 0.182 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.593018e-01 | 0.181 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.628766e-01 | 0.179 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.628766e-01 | 0.179 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.628766e-01 | 0.179 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.633208e-01 | 0.178 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.633208e-01 | 0.178 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.639718e-01 | 0.178 |
| R-HSA-1500620 | Meiosis | 6.672926e-01 | 0.176 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.672926e-01 | 0.176 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.672926e-01 | 0.176 |
| R-HSA-6798695 | Neutrophil degranulation | 6.675728e-01 | 0.176 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.684165e-01 | 0.175 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.712179e-01 | 0.173 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.750970e-01 | 0.171 |
| R-HSA-168255 | Influenza Infection | 6.792769e-01 | 0.168 |
| R-HSA-446728 | Cell junction organization | 6.847235e-01 | 0.164 |
| R-HSA-9658195 | Leishmania infection | 6.912222e-01 | 0.160 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.912222e-01 | 0.160 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.938203e-01 | 0.159 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.010055e-01 | 0.154 |
| R-HSA-2029481 | FCGR activation | 7.045350e-01 | 0.152 |
| R-HSA-1474290 | Collagen formation | 7.080230e-01 | 0.150 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.222411e-01 | 0.141 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.248581e-01 | 0.140 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.248581e-01 | 0.140 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.248581e-01 | 0.140 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.248581e-01 | 0.140 |
| R-HSA-190236 | Signaling by FGFR | 7.248581e-01 | 0.140 |
| R-HSA-422356 | Regulation of insulin secretion | 7.248581e-01 | 0.140 |
| R-HSA-3214847 | HATs acetylate histones | 7.281074e-01 | 0.138 |
| R-HSA-168249 | Innate Immune System | 7.302702e-01 | 0.137 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.313185e-01 | 0.136 |
| R-HSA-428157 | Sphingolipid metabolism | 7.339235e-01 | 0.134 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.344919e-01 | 0.134 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.344919e-01 | 0.134 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.376280e-01 | 0.132 |
| R-HSA-1483255 | PI Metabolism | 7.376280e-01 | 0.132 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.384789e-01 | 0.132 |
| R-HSA-111885 | Opioid Signalling | 7.437901e-01 | 0.129 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.498083e-01 | 0.125 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.585728e-01 | 0.120 |
| R-HSA-397014 | Muscle contraction | 7.602730e-01 | 0.119 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.614259e-01 | 0.118 |
| R-HSA-6803157 | Antimicrobial peptides | 7.670318e-01 | 0.115 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.697855e-01 | 0.114 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.725067e-01 | 0.112 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.725067e-01 | 0.112 |
| R-HSA-418990 | Adherens junctions interactions | 7.725854e-01 | 0.112 |
| R-HSA-9748784 | Drug ADME | 7.725854e-01 | 0.112 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.778536e-01 | 0.109 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.804800e-01 | 0.108 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.804800e-01 | 0.108 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.830755e-01 | 0.106 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.830755e-01 | 0.106 |
| R-HSA-1474244 | Extracellular matrix organization | 7.851105e-01 | 0.105 |
| R-HSA-73886 | Chromosome Maintenance | 7.980198e-01 | 0.098 |
| R-HSA-15869 | Metabolism of nucleotides | 8.062796e-01 | 0.094 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.119395e-01 | 0.090 |
| R-HSA-157118 | Signaling by NOTCH | 8.131401e-01 | 0.090 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.246281e-01 | 0.084 |
| R-HSA-421270 | Cell-cell junction organization | 8.309057e-01 | 0.080 |
| R-HSA-163685 | Integration of energy metabolism | 8.369804e-01 | 0.077 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.369804e-01 | 0.077 |
| R-HSA-6807070 | PTEN Regulation | 8.427038e-01 | 0.074 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.485460e-01 | 0.071 |
| R-HSA-500792 | GPCR ligand binding | 8.494008e-01 | 0.071 |
| R-HSA-392499 | Metabolism of proteins | 8.534979e-01 | 0.069 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.576618e-01 | 0.067 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.697299e-01 | 0.061 |
| R-HSA-418594 | G alpha (i) signalling events | 8.828276e-01 | 0.054 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.976166e-01 | 0.047 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.976166e-01 | 0.047 |
| R-HSA-2559583 | Cellular Senescence | 9.058286e-01 | 0.043 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.123437e-01 | 0.040 |
| R-HSA-8957322 | Metabolism of steroids | 9.149356e-01 | 0.039 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.284681e-01 | 0.032 |
| R-HSA-8951664 | Neddylation | 9.430205e-01 | 0.025 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.482284e-01 | 0.023 |
| R-HSA-382551 | Transport of small molecules | 9.544832e-01 | 0.020 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.560431e-01 | 0.020 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.725983e-01 | 0.012 |
| R-HSA-8953854 | Metabolism of RNA | 9.754331e-01 | 0.011 |
| R-HSA-1483257 | Phospholipid metabolism | 9.765652e-01 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.773128e-01 | 0.010 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.932428e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.997675e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GSK3A |
0.772 | 0.482 | 4 | 0.704 |
GSK3B |
0.767 | 0.479 | 4 | 0.704 |
CLK3 |
0.750 | 0.185 | 1 | 0.688 |
COT |
0.749 | 0.164 | 2 | 0.720 |
NDR2 |
0.742 | 0.106 | -3 | 0.786 |
CLK2 |
0.742 | 0.184 | -3 | 0.635 |
RSK2 |
0.738 | 0.132 | -3 | 0.662 |
CAMK2A |
0.738 | 0.223 | 2 | 0.662 |
PIM3 |
0.737 | 0.101 | -3 | 0.747 |
CDC7 |
0.735 | 0.074 | 1 | 0.720 |
GRK1 |
0.733 | 0.171 | -2 | 0.785 |
SKMLCK |
0.733 | 0.134 | -2 | 0.846 |
CAMK2B |
0.732 | 0.183 | 2 | 0.636 |
MOS |
0.732 | 0.104 | 1 | 0.766 |
HIPK4 |
0.730 | 0.079 | 1 | 0.803 |
RIPK3 |
0.729 | 0.064 | 3 | 0.355 |
RSK4 |
0.728 | 0.117 | -3 | 0.663 |
CAMK2G |
0.728 | 0.148 | 2 | 0.635 |
MTOR |
0.728 | 0.098 | 1 | 0.660 |
AURC |
0.728 | 0.079 | -2 | 0.671 |
SRPK1 |
0.728 | 0.056 | -3 | 0.623 |
P90RSK |
0.728 | 0.081 | -3 | 0.662 |
NDR1 |
0.727 | 0.035 | -3 | 0.747 |
PRKX |
0.727 | 0.121 | -3 | 0.614 |
PRKD2 |
0.725 | 0.046 | -3 | 0.678 |
PIM1 |
0.725 | 0.080 | -3 | 0.676 |
LATS2 |
0.725 | 0.066 | -5 | 0.811 |
MAPKAPK2 |
0.725 | 0.068 | -3 | 0.647 |
PASK |
0.724 | 0.292 | -3 | 0.770 |
GRK6 |
0.724 | 0.184 | 1 | 0.730 |
CHAK2 |
0.724 | 0.059 | -1 | 0.857 |
MSK1 |
0.724 | 0.119 | -3 | 0.628 |
CAMK1B |
0.723 | 0.060 | -3 | 0.724 |
IKKB |
0.722 | 0.010 | -2 | 0.745 |
WNK1 |
0.722 | 0.065 | -2 | 0.862 |
PRKD1 |
0.722 | 0.021 | -3 | 0.731 |
GRK5 |
0.721 | 0.121 | -3 | 0.738 |
PRPK |
0.721 | -0.036 | -1 | 0.797 |
LATS1 |
0.721 | 0.180 | -3 | 0.817 |
PKACG |
0.721 | 0.066 | -2 | 0.746 |
RAF1 |
0.720 | -0.028 | 1 | 0.703 |
DYRK2 |
0.720 | 0.078 | 1 | 0.690 |
ATR |
0.720 | 0.048 | 1 | 0.749 |
RSK3 |
0.720 | 0.037 | -3 | 0.644 |
PKACB |
0.720 | 0.082 | -2 | 0.680 |
FAM20C |
0.719 | 0.053 | 2 | 0.461 |
CDKL1 |
0.718 | 0.020 | -3 | 0.670 |
ERK5 |
0.718 | 0.013 | 1 | 0.687 |
CAMK2D |
0.718 | 0.094 | -3 | 0.721 |
GRK7 |
0.718 | 0.159 | 1 | 0.682 |
PDHK4 |
0.718 | 0.014 | 1 | 0.731 |
IKKA |
0.718 | 0.043 | -2 | 0.742 |
NUAK2 |
0.717 | 0.005 | -3 | 0.728 |
PAK1 |
0.717 | 0.064 | -2 | 0.788 |
NLK |
0.717 | -0.023 | 1 | 0.711 |
HUNK |
0.717 | 0.006 | 2 | 0.673 |
GCN2 |
0.717 | -0.115 | 2 | 0.635 |
P70S6KB |
0.716 | 0.032 | -3 | 0.673 |
MAPKAPK3 |
0.716 | 0.023 | -3 | 0.678 |
CLK4 |
0.716 | 0.081 | -3 | 0.641 |
MST4 |
0.716 | -0.016 | 2 | 0.701 |
DYRK4 |
0.716 | 0.100 | 1 | 0.574 |
MNK1 |
0.715 | 0.068 | -2 | 0.804 |
PKN2 |
0.715 | 0.012 | -3 | 0.713 |
RIPK1 |
0.715 | 0.073 | 1 | 0.783 |
CDKL5 |
0.715 | 0.005 | -3 | 0.667 |
MLK3 |
0.714 | 0.028 | 2 | 0.590 |
MSK2 |
0.714 | 0.046 | -3 | 0.621 |
DLK |
0.714 | 0.123 | 1 | 0.717 |
CAMLCK |
0.714 | 0.036 | -2 | 0.844 |
MLK1 |
0.714 | -0.009 | 2 | 0.653 |
DSTYK |
0.713 | -0.036 | 2 | 0.723 |
CDK1 |
0.713 | 0.049 | 1 | 0.548 |
PKCB |
0.713 | 0.029 | 2 | 0.582 |
TBK1 |
0.713 | -0.095 | 1 | 0.584 |
NIK |
0.713 | 0.008 | -3 | 0.757 |
IKKE |
0.712 | -0.064 | 1 | 0.579 |
IRE1 |
0.712 | -0.000 | 1 | 0.807 |
MNK2 |
0.712 | 0.035 | -2 | 0.793 |
ICK |
0.712 | 0.033 | -3 | 0.721 |
PKCG |
0.712 | 0.020 | 2 | 0.588 |
NEK6 |
0.711 | -0.062 | -2 | 0.817 |
CLK1 |
0.711 | 0.060 | -3 | 0.618 |
DAPK2 |
0.711 | 0.015 | -3 | 0.740 |
PKN3 |
0.711 | -0.031 | -3 | 0.715 |
PKCD |
0.711 | -0.002 | 2 | 0.612 |
BMPR2 |
0.711 | -0.107 | -2 | 0.866 |
HIPK2 |
0.710 | 0.039 | 1 | 0.603 |
MLK2 |
0.710 | -0.025 | 2 | 0.644 |
MARK4 |
0.710 | -0.058 | 4 | 0.308 |
AURB |
0.710 | 0.042 | -2 | 0.668 |
TSSK1 |
0.709 | -0.010 | -3 | 0.775 |
AMPKA1 |
0.709 | -0.039 | -3 | 0.751 |
ULK2 |
0.709 | -0.124 | 2 | 0.596 |
DRAK1 |
0.709 | 0.097 | 1 | 0.683 |
CAMK1G |
0.709 | 0.069 | -3 | 0.622 |
TSSK2 |
0.708 | -0.001 | -5 | 0.850 |
MYLK4 |
0.708 | 0.043 | -2 | 0.763 |
PKCZ |
0.708 | 0.029 | 2 | 0.606 |
KIS |
0.708 | -0.031 | 1 | 0.575 |
CK2A1 |
0.707 | 0.156 | 1 | 0.617 |
GRK4 |
0.707 | 0.033 | -2 | 0.794 |
PAK3 |
0.707 | 0.010 | -2 | 0.783 |
MASTL |
0.707 | -0.039 | -2 | 0.800 |
BMPR1B |
0.707 | 0.064 | 1 | 0.695 |
SRPK2 |
0.707 | -0.002 | -3 | 0.549 |
AMPKA2 |
0.707 | -0.029 | -3 | 0.724 |
PKR |
0.707 | 0.090 | 1 | 0.803 |
PLK3 |
0.706 | 0.086 | 2 | 0.636 |
DNAPK |
0.706 | 0.097 | 1 | 0.599 |
CDK18 |
0.706 | 0.016 | 1 | 0.516 |
CDK7 |
0.706 | -0.010 | 1 | 0.564 |
NEK7 |
0.706 | -0.098 | -3 | 0.744 |
PKCA |
0.706 | 0.008 | 2 | 0.570 |
PLK1 |
0.705 | 0.065 | -2 | 0.772 |
ATM |
0.705 | 0.013 | 1 | 0.695 |
CAMK4 |
0.705 | -0.014 | -3 | 0.707 |
JNK2 |
0.704 | 0.051 | 1 | 0.507 |
HIPK1 |
0.704 | 0.035 | 1 | 0.694 |
MLK4 |
0.704 | -0.003 | 2 | 0.575 |
CK2A2 |
0.703 | 0.104 | 1 | 0.630 |
PKG2 |
0.703 | 0.027 | -2 | 0.687 |
SMG1 |
0.703 | 0.045 | 1 | 0.719 |
PDHK1 |
0.703 | -0.154 | 1 | 0.701 |
TGFBR1 |
0.703 | 0.045 | -2 | 0.789 |
SRPK3 |
0.703 | -0.013 | -3 | 0.583 |
TGFBR2 |
0.703 | -0.093 | -2 | 0.766 |
ULK1 |
0.702 | -0.086 | -3 | 0.704 |
CDK8 |
0.702 | -0.017 | 1 | 0.553 |
JNK3 |
0.702 | 0.043 | 1 | 0.545 |
PKCH |
0.702 | 0.004 | 2 | 0.558 |
TLK2 |
0.701 | 0.049 | 1 | 0.744 |
CDK19 |
0.701 | -0.010 | 1 | 0.516 |
WNK3 |
0.701 | -0.142 | 1 | 0.717 |
NEK9 |
0.701 | -0.084 | 2 | 0.646 |
CHAK1 |
0.701 | -0.029 | 2 | 0.583 |
CDK3 |
0.700 | 0.014 | 1 | 0.487 |
MARK3 |
0.700 | -0.031 | 4 | 0.270 |
DCAMKL1 |
0.700 | 0.037 | -3 | 0.689 |
ANKRD3 |
0.700 | -0.061 | 1 | 0.748 |
ALK4 |
0.700 | 0.015 | -2 | 0.813 |
AKT2 |
0.700 | 0.015 | -3 | 0.567 |
AURA |
0.699 | 0.034 | -2 | 0.644 |
IRE2 |
0.699 | -0.052 | 2 | 0.548 |
MELK |
0.699 | -0.040 | -3 | 0.696 |
NIM1 |
0.699 | -0.075 | 3 | 0.344 |
DYRK3 |
0.699 | 0.058 | 1 | 0.732 |
PAK2 |
0.699 | -0.002 | -2 | 0.770 |
CDK10 |
0.699 | 0.027 | 1 | 0.544 |
BRSK1 |
0.699 | -0.053 | -3 | 0.677 |
PRKD3 |
0.699 | -0.027 | -3 | 0.612 |
CDK5 |
0.698 | -0.028 | 1 | 0.589 |
PKACA |
0.698 | 0.046 | -2 | 0.639 |
CDK2 |
0.698 | -0.014 | 1 | 0.629 |
QSK |
0.698 | -0.063 | 4 | 0.277 |
TTBK2 |
0.697 | -0.075 | 2 | 0.535 |
BCKDK |
0.697 | -0.136 | -1 | 0.731 |
VRK2 |
0.697 | 0.018 | 1 | 0.786 |
CDK17 |
0.696 | -0.000 | 1 | 0.469 |
ALK2 |
0.696 | 0.046 | -2 | 0.789 |
NUAK1 |
0.696 | -0.066 | -3 | 0.684 |
P38B |
0.696 | 0.032 | 1 | 0.531 |
ERK1 |
0.696 | 0.007 | 1 | 0.516 |
CDK13 |
0.696 | -0.017 | 1 | 0.542 |
YSK4 |
0.695 | -0.018 | 1 | 0.643 |
PAK6 |
0.695 | 0.006 | -2 | 0.710 |
GRK2 |
0.695 | 0.030 | -2 | 0.705 |
P38A |
0.695 | 0.009 | 1 | 0.597 |
PIM2 |
0.695 | 0.007 | -3 | 0.624 |
PHKG1 |
0.695 | -0.088 | -3 | 0.722 |
SGK3 |
0.695 | -0.000 | -3 | 0.656 |
ERK2 |
0.694 | -0.004 | 1 | 0.573 |
BRSK2 |
0.694 | -0.084 | -3 | 0.701 |
QIK |
0.694 | -0.091 | -3 | 0.713 |
ACVR2B |
0.693 | 0.013 | -2 | 0.772 |
JNK1 |
0.693 | 0.053 | 1 | 0.510 |
PLK2 |
0.693 | 0.103 | -3 | 0.671 |
CDK9 |
0.692 | -0.023 | 1 | 0.545 |
CDK16 |
0.692 | 0.005 | 1 | 0.489 |
MEK1 |
0.692 | -0.058 | 2 | 0.683 |
MST3 |
0.692 | 0.016 | 2 | 0.696 |
P38G |
0.691 | 0.001 | 1 | 0.461 |
CHK1 |
0.691 | -0.025 | -3 | 0.762 |
DCAMKL2 |
0.691 | 0.012 | -3 | 0.698 |
MPSK1 |
0.691 | 0.053 | 1 | 0.764 |
NEK2 |
0.691 | -0.064 | 2 | 0.629 |
DYRK1B |
0.691 | 0.011 | 1 | 0.596 |
SSTK |
0.691 | -0.021 | 4 | 0.259 |
CK1E |
0.691 | -0.013 | -3 | 0.456 |
CDK14 |
0.691 | -0.001 | 1 | 0.554 |
GAK |
0.691 | 0.137 | 1 | 0.748 |
SNRK |
0.691 | -0.107 | 2 | 0.526 |
CDK12 |
0.690 | -0.015 | 1 | 0.516 |
MAPKAPK5 |
0.690 | -0.034 | -3 | 0.579 |
SIK |
0.690 | -0.077 | -3 | 0.645 |
DYRK1A |
0.690 | -0.013 | 1 | 0.636 |
ACVR2A |
0.690 | -0.018 | -2 | 0.762 |
BMPR1A |
0.689 | 0.036 | 1 | 0.663 |
IRAK4 |
0.689 | -0.029 | 1 | 0.770 |
PKCE |
0.689 | 0.017 | 2 | 0.569 |
BUB1 |
0.689 | 0.136 | -5 | 0.761 |
STK33 |
0.689 | 0.071 | 2 | 0.505 |
MARK2 |
0.688 | -0.096 | 4 | 0.244 |
MEKK3 |
0.688 | -0.004 | 1 | 0.694 |
P70S6K |
0.688 | -0.008 | -3 | 0.577 |
SMMLCK |
0.688 | 0.020 | -3 | 0.678 |
CAMK1D |
0.687 | 0.013 | -3 | 0.582 |
DAPK1 |
0.687 | 0.062 | -3 | 0.654 |
MARK1 |
0.687 | -0.077 | 4 | 0.273 |
WNK4 |
0.687 | -0.038 | -2 | 0.843 |
MAK |
0.687 | 0.069 | -2 | 0.807 |
PAK4 |
0.686 | 0.022 | -2 | 0.669 |
PLK4 |
0.686 | -0.076 | 2 | 0.497 |
MOK |
0.686 | 0.069 | 1 | 0.777 |
PKCI |
0.686 | -0.006 | 2 | 0.586 |
GRK3 |
0.685 | 0.038 | -2 | 0.658 |
HIPK3 |
0.685 | -0.024 | 1 | 0.658 |
TLK1 |
0.685 | -0.027 | -2 | 0.795 |
NEK5 |
0.685 | -0.045 | 1 | 0.747 |
MEK5 |
0.684 | -0.089 | 2 | 0.656 |
PKCT |
0.684 | -0.048 | 2 | 0.561 |
DAPK3 |
0.684 | 0.021 | -3 | 0.685 |
CK1G1 |
0.684 | -0.020 | -3 | 0.455 |
CK1A2 |
0.684 | 0.011 | -3 | 0.404 |
PERK |
0.683 | -0.087 | -2 | 0.801 |
AKT1 |
0.682 | -0.015 | -3 | 0.598 |
P38D |
0.682 | 0.015 | 1 | 0.465 |
YANK3 |
0.682 | 0.039 | 2 | 0.354 |
ERK7 |
0.681 | -0.009 | 2 | 0.459 |
TAO3 |
0.681 | -0.043 | 1 | 0.674 |
LKB1 |
0.681 | 0.007 | -3 | 0.742 |
PAK5 |
0.681 | -0.006 | -2 | 0.658 |
PRP4 |
0.680 | -0.026 | -3 | 0.670 |
MRCKA |
0.680 | 0.043 | -3 | 0.646 |
CAMKK2 |
0.680 | 0.049 | -2 | 0.775 |
GCK |
0.680 | 0.045 | 1 | 0.671 |
PINK1 |
0.679 | -0.081 | 1 | 0.786 |
CAMKK1 |
0.678 | -0.005 | -2 | 0.767 |
ZAK |
0.678 | -0.114 | 1 | 0.656 |
CK1D |
0.678 | -0.010 | -3 | 0.412 |
NEK11 |
0.678 | -0.057 | 1 | 0.656 |
MEKK2 |
0.678 | -0.102 | 2 | 0.623 |
HASPIN |
0.678 | 0.113 | -1 | 0.866 |
HRI |
0.677 | -0.129 | -2 | 0.813 |
PHKG2 |
0.677 | -0.094 | -3 | 0.667 |
SGK1 |
0.677 | 0.018 | -3 | 0.503 |
ROCK2 |
0.676 | 0.032 | -3 | 0.690 |
MEKK1 |
0.676 | -0.147 | 1 | 0.692 |
AKT3 |
0.675 | -0.007 | -3 | 0.520 |
BRAF |
0.675 | -0.103 | -4 | 0.819 |
SLK |
0.674 | 0.002 | -2 | 0.730 |
MRCKB |
0.673 | 0.007 | -3 | 0.616 |
VRK1 |
0.673 | 0.028 | 2 | 0.651 |
DMPK1 |
0.673 | 0.059 | -3 | 0.641 |
LRRK2 |
0.673 | 0.021 | 2 | 0.663 |
EEF2K |
0.672 | -0.032 | 3 | 0.354 |
TTBK1 |
0.671 | -0.088 | 2 | 0.470 |
NEK8 |
0.671 | -0.100 | 2 | 0.636 |
HPK1 |
0.671 | -0.001 | 1 | 0.654 |
CHK2 |
0.670 | -0.026 | -3 | 0.513 |
PDHK3_TYR |
0.669 | 0.338 | 4 | 0.403 |
CAMK1A |
0.669 | -0.017 | -3 | 0.536 |
LOK |
0.668 | -0.051 | -2 | 0.779 |
CDK6 |
0.668 | -0.046 | 1 | 0.525 |
PDHK4_TYR |
0.668 | 0.296 | 2 | 0.730 |
CRIK |
0.667 | 0.031 | -3 | 0.611 |
CDK4 |
0.666 | -0.041 | 1 | 0.514 |
NEK4 |
0.666 | -0.107 | 1 | 0.690 |
MAP3K15 |
0.666 | -0.095 | 1 | 0.637 |
MST2 |
0.666 | -0.063 | 1 | 0.671 |
TAO2 |
0.666 | -0.127 | 2 | 0.653 |
TAK1 |
0.666 | 0.006 | 1 | 0.693 |
PDK1 |
0.666 | -0.070 | 1 | 0.676 |
TNIK |
0.666 | -0.075 | 3 | 0.369 |
PKN1 |
0.665 | -0.067 | -3 | 0.592 |
IRAK1 |
0.665 | -0.177 | -1 | 0.745 |
NEK1 |
0.664 | -0.061 | 1 | 0.723 |
MEKK6 |
0.664 | -0.136 | 1 | 0.678 |
KHS2 |
0.663 | -0.032 | 1 | 0.661 |
MST1 |
0.663 | -0.047 | 1 | 0.663 |
ROCK1 |
0.663 | 0.018 | -3 | 0.636 |
SBK |
0.663 | -0.005 | -3 | 0.459 |
HGK |
0.662 | -0.098 | 3 | 0.379 |
KHS1 |
0.661 | -0.061 | 1 | 0.649 |
CK1A |
0.660 | 0.015 | -3 | 0.333 |
MINK |
0.660 | -0.106 | 1 | 0.659 |
PBK |
0.659 | -0.035 | 1 | 0.664 |
MAP2K6_TYR |
0.656 | 0.166 | -1 | 0.801 |
PKG1 |
0.655 | -0.041 | -2 | 0.612 |
OSR1 |
0.654 | -0.067 | 2 | 0.655 |
YSK1 |
0.653 | -0.112 | 2 | 0.629 |
ALPHAK3 |
0.653 | 0.050 | -1 | 0.712 |
BMPR2_TYR |
0.652 | 0.124 | -1 | 0.801 |
TESK1_TYR |
0.652 | 0.003 | 3 | 0.402 |
YANK2 |
0.652 | 0.022 | 2 | 0.356 |
TTK |
0.651 | -0.072 | -2 | 0.782 |
RIPK2 |
0.650 | -0.172 | 1 | 0.601 |
MAP2K4_TYR |
0.649 | 0.041 | -1 | 0.797 |
LIMK2_TYR |
0.649 | 0.009 | -3 | 0.793 |
MYO3B |
0.649 | -0.041 | 2 | 0.635 |
MEK2 |
0.649 | -0.184 | 2 | 0.631 |
PDHK1_TYR |
0.648 | 0.069 | -1 | 0.807 |
MAP2K7_TYR |
0.646 | -0.029 | 2 | 0.678 |
BIKE |
0.646 | -0.020 | 1 | 0.644 |
PKMYT1_TYR |
0.645 | -0.071 | 3 | 0.391 |
DDR1 |
0.643 | -0.016 | 4 | 0.339 |
PINK1_TYR |
0.642 | -0.084 | 1 | 0.753 |
TNK2 |
0.642 | -0.018 | 3 | 0.339 |
EPHA6 |
0.642 | -0.042 | -1 | 0.787 |
DDR2 |
0.642 | 0.074 | 3 | 0.336 |
MYO3A |
0.639 | -0.087 | 1 | 0.719 |
EPHB4 |
0.639 | -0.053 | -1 | 0.754 |
EPHA4 |
0.639 | 0.022 | 2 | 0.663 |
ASK1 |
0.638 | -0.121 | 1 | 0.623 |
NEK3 |
0.637 | -0.204 | 1 | 0.641 |
TXK |
0.637 | -0.026 | 1 | 0.712 |
CK1G2 |
0.637 | 0.032 | -3 | 0.377 |
RET |
0.636 | -0.143 | 1 | 0.705 |
LIMK1_TYR |
0.636 | -0.126 | 2 | 0.642 |
TAO1 |
0.635 | -0.143 | 1 | 0.600 |
CK1G3 |
0.635 | 0.004 | -3 | 0.290 |
YES1 |
0.633 | -0.082 | -1 | 0.762 |
SRMS |
0.633 | -0.026 | 1 | 0.720 |
ABL2 |
0.633 | -0.113 | -1 | 0.736 |
MST1R |
0.632 | -0.198 | 3 | 0.346 |
TNK1 |
0.632 | -0.069 | 3 | 0.332 |
EPHB1 |
0.632 | -0.055 | 1 | 0.699 |
AAK1 |
0.632 | -0.001 | 1 | 0.551 |
ITK |
0.631 | -0.060 | -1 | 0.729 |
FGR |
0.630 | -0.113 | 1 | 0.740 |
ABL1 |
0.630 | -0.112 | -1 | 0.729 |
CSF1R |
0.630 | -0.166 | 3 | 0.338 |
TYRO3 |
0.630 | -0.210 | 3 | 0.333 |
WEE1_TYR |
0.629 | 0.014 | -1 | 0.721 |
FGFR2 |
0.629 | -0.090 | 3 | 0.379 |
INSRR |
0.629 | -0.126 | 3 | 0.327 |
KDR |
0.628 | -0.110 | 3 | 0.331 |
STLK3 |
0.628 | -0.138 | 1 | 0.628 |
FER |
0.627 | -0.145 | 1 | 0.733 |
JAK3 |
0.627 | -0.143 | 1 | 0.679 |
EPHA7 |
0.627 | -0.046 | 2 | 0.645 |
KIT |
0.627 | -0.113 | 3 | 0.352 |
EPHB3 |
0.626 | -0.095 | -1 | 0.735 |
BMX |
0.626 | -0.041 | -1 | 0.670 |
FYN |
0.626 | -0.024 | -1 | 0.731 |
ROS1 |
0.626 | -0.259 | 3 | 0.319 |
EPHA3 |
0.626 | -0.046 | 2 | 0.621 |
EPHB2 |
0.625 | -0.080 | -1 | 0.727 |
MET |
0.625 | -0.115 | 3 | 0.344 |
MERTK |
0.625 | -0.115 | 3 | 0.339 |
FLT1 |
0.625 | -0.028 | -1 | 0.749 |
TYK2 |
0.624 | -0.274 | 1 | 0.688 |
AXL |
0.624 | -0.139 | 3 | 0.342 |
BLK |
0.623 | -0.097 | -1 | 0.746 |
TEK |
0.623 | -0.160 | 3 | 0.320 |
EPHA5 |
0.623 | -0.019 | 2 | 0.645 |
JAK2 |
0.623 | -0.246 | 1 | 0.665 |
PTK2 |
0.623 | 0.026 | -1 | 0.717 |
PTK2B |
0.623 | -0.050 | -1 | 0.709 |
FGFR3 |
0.623 | -0.074 | 3 | 0.361 |
LCK |
0.622 | -0.139 | -1 | 0.751 |
HCK |
0.621 | -0.166 | -1 | 0.745 |
NEK10_TYR |
0.621 | -0.108 | 1 | 0.580 |
TEC |
0.621 | -0.104 | -1 | 0.674 |
PDGFRB |
0.618 | -0.224 | 3 | 0.345 |
EPHA8 |
0.617 | -0.058 | -1 | 0.725 |
FLT3 |
0.617 | -0.202 | 3 | 0.328 |
FLT4 |
0.616 | -0.120 | 3 | 0.347 |
LTK |
0.616 | -0.155 | 3 | 0.324 |
BTK |
0.616 | -0.162 | -1 | 0.707 |
FGFR1 |
0.616 | -0.195 | 3 | 0.329 |
ERBB2 |
0.615 | -0.126 | 1 | 0.659 |
NTRK1 |
0.615 | -0.152 | -1 | 0.735 |
EPHA1 |
0.614 | -0.164 | 3 | 0.325 |
FRK |
0.614 | -0.132 | -1 | 0.751 |
LYN |
0.614 | -0.129 | 3 | 0.310 |
CSK |
0.613 | -0.065 | 2 | 0.633 |
EPHA2 |
0.613 | -0.037 | -1 | 0.696 |
TNNI3K_TYR |
0.613 | -0.154 | 1 | 0.705 |
ALK |
0.613 | -0.208 | 3 | 0.302 |
PTK6 |
0.613 | -0.139 | -1 | 0.679 |
SRC |
0.612 | -0.082 | -1 | 0.724 |
PDGFRA |
0.611 | -0.245 | 3 | 0.342 |
JAK1 |
0.611 | -0.195 | 1 | 0.608 |
SYK |
0.611 | 0.011 | -1 | 0.695 |
MATK |
0.611 | -0.091 | -1 | 0.680 |
INSR |
0.610 | -0.186 | 3 | 0.309 |
ERBB4 |
0.608 | -0.036 | 1 | 0.609 |
FGFR4 |
0.607 | -0.066 | -1 | 0.689 |
NTRK3 |
0.607 | -0.143 | -1 | 0.695 |
EGFR |
0.607 | -0.060 | 1 | 0.585 |
NTRK2 |
0.606 | -0.223 | 3 | 0.325 |
IGF1R |
0.601 | -0.141 | 3 | 0.292 |
MUSK |
0.594 | -0.146 | 1 | 0.600 |
FES |
0.593 | -0.109 | -1 | 0.650 |
ZAP70 |
0.591 | -0.040 | -1 | 0.645 |